Pitt | Swanson Engineering

Functionalized Organic-Inorganic Coatings on 3-D Magnesium Based Scaffolds

Rapid corrosion of magnesium and its alloys in chloride containing solutions, human body fluid, or blood plasma resulting in the uncontrolled release of hydrogen gas have limited their use in clinical applications. Therefore, the development of biocompatible inorganic and/or bio-functionalized coatings that can delay or control the corrosion rate and consequently, the hydrogen gas evolution as well as promote rapid bone regeneration is of immense importance and play a very critical role for the success of Mg scaffolds as an implant. Over the past 10 years our group has successfully developed and optimized stable organic and inorganic coatings on various Mg based alloys to decrease the alloys’ corrosion rate and hydrogen evolution as well as increase the alloys’ surface bioactivity, thus increasing the clinical relevance of Mg based alloys. The coating techniques that we developed are sol-gel, immersion, phosphating bath, layer-by-layer, polymeric dip coatings, MAO, electrophoretic deposition (EPD), fluoride conversion coating, and sodium hydroxide conversion coatings. The in-vivo results have demonstrated excellent biocompatibility of the coatings and have led to delayed degradation of these coated alloys. Furthermore, we have explored the possibility of release of antimicrobial drugs such as vancomycin and model protein bovine serum albumin (BSA) from the inorganic-organic composite coated surfaces of magnesium substrates.

Functionalized Organic-Inorganic Coatings on 3-D Magnesium Based Scaffolds

Cumulative and daily release of vancomycin from biopolymer coated MAO pre-coated samples.

 

 

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