headshot of Morgan Dileo

Morgan Dileo

Assistant Professor
Bioengineering Department


(2015) National Eye Institute (NEI) Young Investigator Travel Grant.

(2012) National Eye Institute (NEI) Travel Grant.

(2011 - 2013) Ocular Tissue Engineering and Regenerative Ophthalmology (OTERO) Fellowship Recipient.

BS, Chemical Engineering and Biomedical Engineering, Carnegie Mellon University, 2002 - 2006

PhD, Bioengineering, University of Pittsburgh, 2006 - 2011

Jimenez, J., Washington, M.A., Resnick, J.L., Nischal, K.K., & Fedorchak, M.V. (2021). A sustained release cysteamine microsphere/thermoresponsive gel eyedrop for corneal cystinosis improves drug stability. DRUG DELIVERY AND TRANSLATIONAL RESEARCH, 11(5), 2224-2238.Springer Science and Business Media LLC. doi: 10.1007/s13346-020-00890-6.

Jimenez, J., Sakthivel, M., Nischal, K.K., & Fedorchak, M.V. (2019). Drug delivery systems and novel formulations to improve treatment of rare corneal disease. DRUG DISCOVERY TODAY, 24(8), 1564-1574.Elsevier BV. doi: 10.1016/j.drudis.2019.03.005.

Washington, M.A., Balmert, S.C., Fedorchak, M.V., Little, S.R., Watkins, S.C., & Meyer, T.Y. (2018). Monomer sequence in PLGA microparticles: Effects on acidic microclimates and in vivo inflammatory response. ACTA BIOMATERIALIA, 65, 259-271.Elsevier BV. doi: 10.1016/j.actbio.2017.10.043.

Bayer, E.A., Jordan, J., Roy, A., Gottardi, R., Fedorchak, M.V., Kumta, P.N., & Little, S.R. (2017). Programmed Platelet-Derived Growth Factor-BB and Bone Morphogenetic Protein-2 Delivery from a Hybrid Calcium Phosphate/Alginate Scaffold. TISSUE ENGINEERING PART A, 23(23-24), 1382-1393.Mary Ann Liebert Inc. doi: 10.1089/ten.tea.2017.0027.

Fedorchak, M.V., Conner, I.P., Schuman, J.S., Cugini, A., & Little, S.R. (2017). Long Term Glaucoma Drug Delivery Using a Topically Retained Gel/Microsphere Eye Drop. SCIENTIFIC REPORTS, 7(1), 8639.Springer Science and Business Media LLC. doi: 10.1038/s41598-017-09379-8.

Ratay, M.L., Glowacki, A.J., Balmert, S.C., Acharya, A.P., Polat, J., Andrews, L.P., Fedorchak, M.V., Schuman, J.S., Vignali, D.A.A., & Little, S.R. (2017). Treg-recruiting microspheres prevent inflammation in a murine model of dry eye disease. JOURNAL OF CONTROLLED RELEASE, 258, 208-217.Elsevier BV. doi: 10.1016/j.jconrel.2017.05.007.

Washington, M.A., Swiner, D.J., Bell, K.R., Fedorchak, M.V., Little, S.R., & Meyer, T.Y. (2017). The impact of monomer sequence and stereochemistry on the swelling and erosion of biodegradable poly(lactic-co-glycolic acid) matrices. BIOMATERIALS, 117, 66-76.Elsevier BV. doi: 10.1016/j.biomaterials.2016.11.037.

Bayer, E.A., Fedorchak, M.V., & Little, S.R. (2016). The Influence of Platelet-Derived Growth Factor and Bone Morphogenetic Protein Presentation on Tubule Organization by Human Umbilical Vascular Endothelial Cells and Human Mesenchymal Stem Cells in Coculture. TISSUE ENGINEERING PART A, 22(21-22), 1296-1304.Mary Ann Liebert Inc. doi: 10.1089/ten.tea.2016.0163.

Mammen, A., Romanowski, E.G., Fedorchak, M.V., Dhaliwal, D.K., Shanks, R.M., & Kowalski, R.P. (2016). Endophthalmitis Prophylaxis Using a Single Drop of Thermoresponsive Controlled-Release Microspheres Loaded with Moxifloxacin in a Rabbit Model. TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, 5(6), 12.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/tvst.5.6.12.

Balmert, S.C., Zmolek, A.C., Glowacki, A.J., Knab, T.D., Rothstein, S.N., Wokpetah, J.M., Fedorchak, M.V., & Little, S.R. (2015). Positive charge of "sticky'' peptides and proteins impedes release from negatively charged PLGA matrices. JOURNAL OF MATERIALS CHEMISTRY B, 3(23), 4723-4734.Royal Society of Chemistry (RSC). doi: 10.1039/c5tb00515a.

Bayer, E.A., Gottardi, R., Fedorchak, M.V., & Little, S.R. (2015). The scope and sequence of growth factor delivery for vascularized bone tissue regeneration. JOURNAL OF CONTROLLED RELEASE, 219, 129-140.Elsevier BV. doi: 10.1016/j.jconrel.2015.08.004.

Guaragno, M.L., Gottardi, R., Fedorchak, M.V., Roy, A., Kumta, P.N., & Little, S.R. (2015). One-step synthesis of fluorescentty labelled, single-walled carbon nanotubes. CHEMICAL COMMUNICATIONS, 51(97), 17233-17236.Royal Society of Chemistry (RSC). doi: 10.1039/c5cc05573c.

Lash, M.H., Fedorchak, M.V., Little, S.R., & McCarthy, J.J. (2015). Fabrication and Characterization of Non-Brownian Particle-Based Crystals. LANGMUIR, 31(3), 898-905.American Chemical Society (ACS). doi: 10.1021/la501511s.

Lash, M.H., Fedorchak, M.V., McCarthy, J.J., & Little, S.R. (2015). Scaling up self-assembly: bottom-up approaches to macroscopic particle organization. SOFT MATTER, 11(28), 5597-5609.Royal Society of Chemistry (RSC). doi: 10.1039/c5sm00764j.

Lash, M.H., Jordan, J.C., Blevins, L.C., Fedorchak, M.V., Little, S.R., & McCarthy, J.J. (2015). Frontispiece: Non‐Brownian Particle‐Based Materials with Microscale and Nanoscale Hierarchy. Angewandte Chemie International Edition, 54(20).Wiley. doi: 10.1002/anie.201582061.

Lash, M.H., Jordan, J.C., Blevins, L.C., Fedorchak, M.V., Little, S.R., & McCarthy, J.J. (2015). Non-Brownian Particle-Based Materials with Microscale and Nanoscale Hierarchy. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 54(20), 5853-5858.Wiley. doi: 10.1002/anie.201500273.

Fedorchak, M.V. (2014). Gender: resolve bias, don't excuse it. NATURE, 505(7485), 618.Springer Science and Business Media LLC. doi: 10.1038/505618a.

Fedorchak, M.V., Conner, I.P., Medina, C.A., Wingard, J.B., Schuman, J.S., & Little, S.R. (2014). 28-day intraocular pressure reduction with a single dose of brimonidine tartrate-loaded microspheres. EXPERIMENTAL EYE RESEARCH, 125, 210-216.Elsevier BV. doi: 10.1016/j.exer.2014.06.013.

Mealy, J.E., Fedorchak, M.V., & Little, S.R. (2014). In vitro characterization of a controlled-release ocular insert for delivery of brimonidine tartrate. ACTA BIOMATERIALIA, 10(1), 87-93.Elsevier BV. doi: 10.1016/j.actbio.2013.09.024.

Rimmele, T., Kaynar, A.M., McLaughlin, J.N., Bishop, J.V., Fedorchak, M.V., Chuasuwan, A., Peng, Z., Singbartl, K., Frederick, D.R., Zhu, L., Carter, M., Federspiel, W.J., Zeevi, A., & Kellum, J.A. (2013). Leukocyte capture and modulation of cell-mediated immunity during human sepsis: an ex vivo study. CRITICAL CARE, 17(2), R59.Springer Science and Business Media LLC. doi: 10.1186/cc12587.

Fisher, J.D., DiLeo, M.V., & Federspiel, W.J. (2012). Investigating Cytokine Binding Using a Previously Reported TNF-Specific Aptamer. Open Journal of Applied Sciences, 02(03), 135-138.Scientific Research Publishing, Inc. doi: 10.4236/ojapps.2012.23019.

Namas, R.A., Namas, R., Lagoa, C., Barclay, D., Mi, Q., Zamora, R., Peng, Z., Wen, X., Fedorchak, M.V., Valenti, I.E., Federspiel, W.J., Kellum, J.A., & Vodovotz, Y. (2012). Hemoadsorption Reprograms Inflammation in Experimental Gram-negative Septic Peritonitis: Insights from In Vivo and In Silico Studies. MOLECULAR MEDICINE, 18(10), 1366-1374.Springer Science and Business Media LLC. doi: 10.2119/molmed.2012.00106.

Peng, Z.Y., Wang, H.Z., Carter, M.J., Dileo, M.V., Bishop, J.V., Zhou, F.H., Wen, X.Y., Rimmele, T., Singbartl, K., Federspiel, W.J., Clermont, G., & Kellum, J.A. (2012). Acute removal of common sepsis mediators does not explain the effects of extracorporeal blood purification in experimental sepsis. KIDNEY INTERNATIONAL, 81(4), 363-369.Elsevier BV. doi: 10.1038/ki.2011.320.

DiLeo, M.V., Fisher, J.D., Burton, B.M., & Federspiel, W.J. (2011). Selective improvement of tumor necrosis factor capture in a cytokine hemoadsorption device using immobilized anti-tumor necrosis factor. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 96B(1), 127-133.Wiley. doi: 10.1002/jbm.b.31748.

DiLeo, M.V., & Federspiel, W.J. (2010). Scaling Issues in the Article Entitled "Cytokines in Blood From Septic Patients Interact With Surface-Immobilized Heparin". ASAIO JOURNAL, 56(4), 383-384.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/MAT.0b013e3181e4bfc3.

DiLeo, M.V., Fisher, J.D., & Federspiel, W.J. (2009). Experimental Validation of a Theoretical Model of Cytokine Capture Using a Hemoadsorption Device. ANNALS OF BIOMEDICAL ENGINEERING, 37(11), 2310-2316.Springer Science and Business Media LLC. doi: 10.1007/s10439-009-9780-4.

DiLeo, M.V., Kellum, J.A., & Federspiel, W.J. (2009). A Simple Mathematical Model of Cytokine Capture Using a Hemoadsorption Device. ANNALS OF BIOMEDICAL ENGINEERING, 37(1), 222-229.Springer Science and Business Media LLC. doi: 10.1007/s10439-008-9587-8.

Fedorchak, M.V., Kowalski, R.P., Romanowski, E.G., Schuman, J.S., & Little, S.R. (2016). Development of a semi-permanent, controlled release antibiotic eye drop. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 57(12).

Research interests

controlled release
drug delivery
regenerative medicine
tissue engineering