headshot of David Gau

David Gau

Visiting Lecturer
Bioengineering Department


PhD, University of Pittsburgh

BS, University of Pittsburgh

Clark, R.M., Besterfield-Sacre, M., Dickerson, S., & Gau, D. (2023). Impact of COVID-19 on Engineering Students in the Middle Phases of the Pandemic: Academic Motivation, Valued College Experiences, and Stress. INTERNATIONAL JOURNAL OF ENGINEERING EDUCATION, 39(1), 30-47.

Gau, D., Daoud, A., Allen, A., Joy, M., Sagan, A., Lee, S., Lucas, P.C., Duensing, S., Boone, D., Osmanbeyoglu, H.U., & Roy, P. (2023). Vascular endothelial profilin-1 drives a protumorigenic tumor microenvironment and tumor progression in renal cancer. J Biol Chem, 299(8), 105044.Elsevier BV. doi: 10.1016/j.jbc.2023.105044.

Allen, A., Gau, D., & Roy, P. (2021). The role of profilin-1 in cardiovascular diseases. JOURNAL OF CELL SCIENCE, 134(9).The Company of Biologists. doi: 10.1242/jcs.249060.

Gau, D., Vignaud, L., Francoeur, P., Koes, D., Guillonneau, X., & Roy, P. (2021). Inhibition of ocular neovascularization by novel anti-angiogenic compound. EXPERIMENTAL EYE RESEARCH, 213, 108861.Elsevier BV. doi: 10.1016/j.exer.2021.108861.

Allen, A., Gau, D., Francoeur, P., Sturm, J., Wang, Y., Martin, R., Maranchie, J., Duensing, A., Kaczorowski, A., Duensing, S., Wu, L., Lotze, M.T., Koes, D., Storkus, W.J., & Roy, P. (2020). Actin-binding protein profilin1 promotes aggressiveness of clear-cell renal cell carcinoma cells. JOURNAL OF BIOLOGICAL CHEMISTRY, 295(46), 15636-15649.Elsevier BV. doi: 10.1074/jbc.RA120.013963.

Gau, D., Vignaud, L., Allen, A., Guo, Z., Sahel, J., Boone, D., Koes, D., Guillonneau, X., & Roy, P. (2020). Disruption of profilin1 function suppresses developmental and pathological retinal neovascularization. JOURNAL OF BIOLOGICAL CHEMISTRY, 295(28), 9618-9629.Elsevier BV. doi: 10.1074/jbc.RA120.012613.

Goldschmidt, E., Schneck, M., Gau, D.M., Carey, L., Rasmussen, J., Ferreyro, B., Ajler, P., Snyderman, C., Wang, E., Fernandez-Miranda, J., & Gardner, P.A. (2020). Effect of oxidized cellulose on human respiratory mucosa and submucosa and its implications for endoscopic skull-base approaches. INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY, 10(3), 282-288.Wiley. doi: 10.1002/alr.22495.

Gau, D., Veon, W., Shroff, S.G., & Roy, P. (2019). The VASP-profilin1 (Pfn1) interaction is critical for efficient cell migration and is regulated by cell-substrate adhesion in a PKA-dependent manner. JOURNAL OF BIOLOGICAL CHEMISTRY, 294(17), 6972-6985.Elsevier BV. doi: 10.1074/jbc.RA118.005255.

Chakraborty, S., Jiang, C., Gau, D., Oddo, M., Ding, Z., Vollmer, L., Joy, M., Schiemann, W., Stolz, D.B., Vogt, A., Ghosh, S., & Roy, P. (2018). Profilin-1 deficiency leads to SMAD3 upregulation and impaired 3D outgrowth of breast cancer cells. BRITISH JOURNAL OF CANCER, 119(9), 1106-1117.Springer Science and Business Media LLC. doi: 10.1038/s41416-018-0284-6.

Gau, D., & Roy, P. (2018). SRF'ing and SAP'ing - the role of MRTF proteins in cell migration. JOURNAL OF CELL SCIENCE, 131(19).The Company of Biologists. doi: 10.1242/jcs.218222.

Gau, D., Lewis, T., McDermott, L., Wipf, P., Koes, D., & Roy, P. (2018). Structure-based virtual screening identifies a small-molecule inhibitor of the profilin 1-actin interaction. JOURNAL OF BIOLOGICAL CHEMISTRY, 293(7), 2606-2616.Elsevier BV. doi: 10.1074/jbc.M117.809137.

Gau, D., Veon, W., Capasso, T.L., Bottcher, R., Shroff, S., Roman, B.L., & Roy, P. (2017). Pharmacological intervention of MKL/SRF signaling by CCG-1423 impedes endothelial cell migration and angiogenesis. ANGIOGENESIS, 20(4), 663-672.Springer Science and Business Media LLC. doi: 10.1007/s10456-017-9560-y.

Joy, M., Gau, D., Castellucci, N., Prywes, R., & Roy, P. (2017). The myocardin-related transcription factor MKL co-regulates the cellular levels of two profilin isoforms. JOURNAL OF BIOLOGICAL CHEMISTRY, 292(28), 11777-11791.Elsevier BV. doi: 10.1074/jbc.M117.781104.

Gau, D., Veon, W., Zeng, X., Yates, N., Shroff, S.G., Koes, D.R., & Roy, P. (2016). Threonine 89 Is an Important Residue of Profilin-1 That Is Phosphorylatable by Protein Kinase A. In Paudel, H.K. (Ed.). PLOS ONE, 11(5), e0156313.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0156313.

Gau, D.M., Lesnock, J.L., Hood, B.L., Bhargava, R., Sun, M., Darcy, K., Luthra, S., Chandran, U., Conrads, T.P., Edwards, R.P., Kelley, J.L., Krivak, T.C., & Roy, P. (2015). BRCA1 deficiency in ovarian cancer is associated with alteration in expression of several key regulators of cell motility - A proteomics study. CELL CYCLE, 14(12), 1884-1892.Informa UK Limited. doi: 10.1080/15384101.2015.1036203.

Coumans, J.V.F., Gau, D., Poljak, A., Wasinger, V., Roy, P., & Moens, P. (2014). Green fluorescent protein expression triggers proteome changes in breast cancer cells. EXPERIMENTAL CELL RESEARCH, 320(1), 33-45.Elsevier BV. doi: 10.1016/j.yexcr.2013.07.019.

Coumans, J.V.F., Gau, D., Poljak, A., Wasinger, V., Roy, P., & Moens, P.D.J. (2014). Profilin-1 Overexpression in MDA-MB-231 Breast Cancer Cells Is Associated with Alterations in Proteomics Biomarkers of Cell Proliferation, Survival, and Motility as Revealed by Global Proteomics Analyses. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY, 18(12), 778-791.Mary Ann Liebert Inc. doi: 10.1089/omi.2014.0075.

Gau, D., Veon, W., Koes, D., Shroff, S., & Roy, P. (2014). T89 Phosphorylation is a Novel Post-Translational Modification for Critical Structure-Function Regulation of Profilin-1. MOLECULAR BIOLOGY OF THE CELL, 25.

Gau, D., Ding, Z., Baty, C., & Roy, P. (2011). Fluorescence Resonance Energy Transfer (FRET)-based Detection of Profilin-VASP Interaction. CELLULAR AND MOLECULAR BIOENGINEERING, 4(1), 1-8.Springer Science and Business Media LLC. doi: 10.1007/s12195-010-0133-z.

Ding, Z., Gaua, D., Deasy, B., Wells, A., & Roy, P. (2009). Both actin and polyproline interactions of profilin-1 are required for migration, invasion and capillary morphogenesis of vascular endothelial cells. EXPERIMENTAL CELL RESEARCH, 315(17), 2963-2973.Elsevier BV. doi: 10.1016/j.yexcr.2009.07.004.

Gau, D., Joy, M., Prywes, R., & Roy, P. (2017). Cellular externalization control of actin-binding protein profilin-1 is a novel mechanism for MKL-dependent regulation of cell migration. In MOLECULAR BIOLOGY OF THE CELL, 28.

Gau, D., Lewis, T., Mcdermott, L., Wipf, P., Koes, D., & Roy, P. (2017). Structure-based virtual screening to identify first-generation inhibitor of profilin1: actin interaction with anti-angiogenic property. In MOLECULAR BIOLOGY OF THE CELL, 28.

Sunseri, J., Koes, D.R., Roy, P., & Gau, D. (2017). Characterization of Profilin Binding Kinetics using Ensemble Molecular Dynamics Simulations. In BIOPHYSICAL JOURNAL, 112(3), (p. 287A).Elsevier BV. doi: 10.1016/j.bpj.2016.11.1554.

Gau, D., Veon, W., Capasso, T., Joy, M.E., Roman, B., Koes, D., & Roy, P. (2016). Small molecule-mediated inhibitions of transcriptional cofactor MKL and its downstream target profilin impedes endothelial cell migration and angiogenesis. In MOLECULAR BIOLOGY OF THE CELL, 27.

Joy, M.E., Gau, D., Castellucci, N., & Roy, P. (2016). Profilin occupies a critical node in actin/MKL/SRF signaling circuit. In MOLECULAR BIOLOGY OF THE CELL, 27.

Gau, D., Veon, W., Guo, Z., & Roy, P. (2015). Hyperactivation of Protein Kinase A inhibits endothelial cell migration and angiogenesis through phosphorylating and inhibiting actin-binding protein Profilin-1. In MOLECULAR BIOLOGY OF THE CELL, 26.

Gau, D.M., Lesnock, J., Krivak, T., Edwards, R., & Roy, P. (2014). BRCA1 impacts ovarian cancer cell migration through modulating Pfn1 expression. Annual meeting of the American Association of Cancer Research. doi: 10.1158/1538-7445.AM2014-LB-70.

Gau, D., Salvemini, I., Reid, J., Bagatolli, L., & Moens, P. (2012). Low PIP2 molar fractions induce nanometer size clustering in giant unilamellar vesicles containing POPC. In MOLECULAR BIOLOGY OF THE CELL, 23.