headshot of Bruce Pitt

Bruce Pitt



Tyurina, Y.Y., Shrivastava, I., Tyurin, V.A., Mao, G., Dar, H.H., Watkins, S., Epperly, M., Bahar, I., Shvedova, A.A., Pitt, B., Wenzel, S.E., Mallampalli, R.K., Sadovsky, Y., Gabrilovich, D., Greenberger, J.S., Bayir, H., & Kagan, V.E. (2018). "Only a Life Lived for Others Is Worth Living": Redox Signaling by Oxygenated Phospholipids in Cell Fate Decisions. ANTIOXIDANTS & REDOX SIGNALING, 29(13), 1333-1358.Mary Ann Liebert Inc. doi: 10.1089/ars.2017.7124.

Buland, J.R., Wasserloos, K.J., Tyurin, V.A., Tyurina, Y.Y., Amoscato, A.A., Mallampalli, R.K., Chen, B.B., Zhao, J., Zhao, Y., Ofori-Acquah, S., Kagan, V.E., & Pitt, B.R. (2016). Biosynthesis of oxidized lipid mediators via lipoprotein-associated phospholipase A2 hydrolysis of extracellular cardiolipin induces endothelial toxicity. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 311(2), L303-L316.American Physiological Society. doi: 10.1152/ajplung.00038.2016.

Stacy, S.L., Brink, L.L., Larkin, J.C., Sadovsky, Y., Goldstein, B.D., Pitt, B.R., & Talbott, E.O. (2015). Perinatal Outcomes and Unconventional Natural Gas Operations in Southwest Pennsylvania. In Meliker, J. (Ed.). PLOS ONE, 10(6), e0126425.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0126425.

Andes, E. (2014). An examination of scenarios in dengue fever transmission with considerations in vector control, blood donation, and health communications in the United States. University of Pittsburgh.

Watson, K. (2014). Pharmaceuticals in the water: histological effects and intersex wildlife and sexual disruption. University of Pittsburgh.

Li, H.H., Li, J., Wasserloos, K.J., Wallace, C., Sullivan, M.G., Bauer, P.M., Stolz, D.B., Lee, J.S., Watkins, S.C., St Croix, C.M., Pitt, B.R., & Zhang, L.M. (2013). Caveolae-Dependent and -Independent Uptake of Albumin in Cultured Rodent Pulmonary Endothelial Cells. In Zhao, Y.Y. (Ed.). PLOS ONE, 8(11), e81903.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0081903.

Cioffi, D.L., Wu, S., Chen, H., Alexeyev, M., St Croix, C.M., Pitt, B.R., Uhlig, S., & Stevens, T. (2012). Orai1 Determines Calcium Selectivity of an Endogenous TRPC Heterotetramer Channel. CIRCULATION RESEARCH, 110(11), 1435-+.Ovid Technologies (Wolters Kluwer Health). doi: 10.1161/CIRCRESAHA.112.269506.

Gorbunov, N.V., Atkins, J.L., Gurusamy, N., & Pitt, B.R. (2012). Iron-induced remodeling in cultured rat pulmonary artery endothelial cells. BIOMETALS, 25(1), 203-217.Springer Science and Business Media LLC. doi: 10.1007/s10534-011-9498-2.

Li, H.H., Li, Q., Liu, P., Liu, Y., Li, J., Wasserloos, K., Chao, W., You, M., Oury, T.D., Chhinder, S., Hackam, D.J., Billiar, T.R., Leikauf, G.D., Pitt, B.R., & Zhang, L.M. (2012). WNT1-Inducible Signaling Pathway Protein 1 Contributes to Ventilator-Induced Lung Injury. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 47(4), 528-535.American Thoracic Society. doi: 10.1165/rcmb.2012-0127OC.

Sparvero, L.J., Amoscato, A.A., Dixon, C.E., Long, J.B., Kochanek, P.M., Pitt, B.R., Bayir, H., & Kagan, V.E. (2012). Mapping of phospholipids by MALDI imaging (MALDI-MSI): realities and expectations. CHEMISTRY AND PHYSICS OF LIPIDS, 165(5), 545-562.Elsevier BV. doi: 10.1016/j.chemphyslip.2012.06.001.

Thambiayya, K., Wasserloos, K., Kagan, V.E., Stoyanovsky, D., & Pitt, B.R. (2012). A critical role for increased labile zinc in reducing sensitivity of cultured sheep pulmonary artery endothelial cells to LPS-induced apoptosis. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 302(12), L1287-L1295.American Physiological Society. doi: 10.1152/ajplung.00385.2011.

Atkinson, J., Kapralov, A.A., Yanamala, N., Tyurina, Y.Y., Amoscato, A.A., Pearce, L., Peterson, J., Huang, Z., Jiang, J., Samhan-Arias, A.K., Maeda, A., Feng, W., Wasserloos, K., Belikova, N.A., Tyurin, V.A., Wang, H., Fletcher, J., Wang, Y., Vlasova, I.I., Klein-Seetharaman, J., Stoyanovsky, D.A., Bayîr, H., Pitt, B.R., Epperly, M.W., Greenberger, J.S., & Kagan, V.E. (2011). A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced death. Nature communications, 2, 497.

Bernal, P.J., Bauer, E.M., Cao, R., Maniar, S., Mosher, M., Chen, J., Wang, Q.J., Glorioso, J.C., Pitt, B.R., Watkins, S.C., & St Croix, C.M. (2011). A role for zinc in regulating hypoxia-induced contractile events in pulmonary endothelium. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 300(6), L874-L886.American Physiological Society. doi: 10.1152/ajplung.00328.2010.

Cambal, L.K., Swanson, M.R., Yuan, Q., Weitz, A.C., Li, H.H., Pitt, B.R., Pearce, L.L., & Peterson, J. (2011). Acute, Sublethal Cyanide Poisoning in Mice Is Ameliorated by Nitrite Alone: Complications Arising from Concomitant Administration of Nitrite and Thiosulfate as an Antidotal Combination. CHEMICAL RESEARCH IN TOXICOLOGY, 24(7), 1104-1112.American Chemical Society (ACS). doi: 10.1021/tx2001042.

Li, H.H., Xu, J., Wasserloos, K.J., Li, J., Tyurina, Y.Y., Kagan, V.E., Wang, X., Chen, A.F., Liu, Z.Q., Stoyanovsky, D., Pitt, B.R., & Zhang, L.M. (2011). Cytoprotective effects of albumin, nitrosated or reduced, in cultured rat pulmonary vascular cells. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 300(4), L526-L533.American Physiological Society. doi: 10.1152/ajplung.00282.2010.

Thambiayya, K., Wasserloos, K.J., Huang, Z., Kagan, V.E., Croix, C.M.S., & Pitt, B.R. (2011). LPS-induced decrease in intracellular labile zinc, [Zn]i, contributes to apoptosis in cultured sheep pulmonary artery endothelial cells. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 300(4), L624-L632.American Physiological Society. doi: 10.1152/ajplung.00376.2010.

Tyurina, Y.Y., Tyurin, V.A., Kapralova, V.I., Wasserloos, K., Mosher, M., Epperly, M.W., Greenberger, J.S., Pitt, B.R., & Kagan, V.E. (2011). Oxidative Lipidomics of γ-Radiation-Induced Lung Injury: Mass Spectrometric Characterization of Cardiolipin and Phosphatidylserine Peroxidation. RADIATION RESEARCH, 175(5), 610-621.Radiation Research Society. doi: 10.1667/RR2297.1.

Gamble, C., Talbott, E., Youk, A., Holguin, F., Pitt, B., Silveira, L., Bleecker, E., Busse, W., Calhoun, W., Castro, M., Chung, K.F., Erzurum, S., Israel, E., & Wenzel, S. (2010). Racial differences in biologic predictors of severe asthma: Data from the Severe Asthma Research Program. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 126(6), 1149-U133.Elsevier BV. doi: 10.1016/j.jaci.2010.08.049.

John, E., Laskow, T.C., Buchser, W.J., Pitt, B.R., Basse, P.H., Butterfield, L.H., Kalinski, P., & Lotze, M.T. (2010). Zinc in innate and adaptive tumor immunity. JOURNAL OF TRANSLATIONAL MEDICINE, 8(1), 118.Springer Science and Business Media LLC. doi: 10.1186/1479-5876-8-118.

Li, H., Cao, R., Wasserlos, K.J., Bernal, P., Liu, Z.Q., Pitt, B.R., & St Croix, C.M. (2010). Nitric oxide and zinc homeostasis in pulmonary endothelium. OXIDATIVE/NITROSATIVE STRESS AND DISEASE, 1203(1), 73-78.Wiley. doi: 10.1111/j.1749-6632.2010.05558.x.

Li, H., Su, X., Yan, X., Wasserloos, K., Chao, W., Kaynar, A.M., Liu, Z.Q., Leikauf, G.D., Pitt, B.R., & Zhang, L.M. (2010). Toll-like Receptor 4-Myeloid Differentiation Factor 88 Signaling Contributes to Ventilator-induced Lung Injury in Mice. ANESTHESIOLOGY, 113(3), 619-629.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/ALN.0b013e3181e89ab2.

Phillippi, J.A., Eskay, M.A., Kubala, A.A., Pitt, B.R., & Gleason, T.G. (2010). Altered Oxidative Stress Responses and Increased Type I Collagen Expression in Bicuspid Aortic Valve Patients. ANNALS OF THORACIC SURGERY, 90(6), 1893-1898.Elsevier BV. doi: 10.1016/j.athoracsur.2010.07.069.

Polk, A.A., Maul, T.M., McKeel, D.T., Snyder, T.A., Lehocky, C.A., Pitt, B., Stolz, D.B., Federspiel, W.J., & Wagner, W.R. (2010). A Biohybrid Artificial Lung Prototype With Active Mixing of Endothelialized Microporous Hollow Fibers. BIOTECHNOLOGY AND BIOENGINEERING, 106(3), 490-500.Wiley. doi: 10.1002/bit.22675.

Sparvero, L.J., Amoscato, A.A., Kochanek, P.M., Pitt, B.R., Kagan, V.E., & Bayir, H. (2010). Mass-spectrometry based oxidative lipidomics and lipid imaging: applications in traumatic brain injury. JOURNAL OF NEUROCHEMISTRY, 115(6), 1322-1336.Wiley. doi: 10.1111/j.1471-4159.2010.07055.x.

Szczepaniak, W.S., Pitt, B.R., & McVerry, B.J. (2010). S1P2 receptor-dependent Rho-kinase activation mediates vasoconstriction in the murine pulmonary circulation induced by sphingosine 1-phosphate. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 299(1), L137-L145.American Physiological Society. doi: 10.1152/ajplung.00233.2009.

Tyurina, Y.Y., Tyurin, V.A., Kaynar, A.M., Kapralova, V.I., Wasserloos, K., Li, J., Mosher, M., Wright, L., Wipf, P., Watkins, S., Pitt, B.R., & Kagan, V.E. (2010). Oxidative lipidomics of hyperoxic acute lung injury: mass spectrometric characterization of cardiolipin and phosphatidylserine peroxidation. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 299(1), L73-L85.American Physiological Society. doi: 10.1152/ajplung.00035.2010.

Garner, A.L., St Croix, C.M., Pitt, B.R., Leikauf, G.D., Ando, S., & Koide, K. (2009). Specific fluorogenic probes for ozone in biological and atmospheric samples. NATURE CHEMISTRY, 1(4), 316-321.Springer Science and Business Media LLC. doi: 10.1038/NCHEM.240.

Kagan, V.E., Bayir, H.A., Belikova, N.A., Kapralov, O., Tyurina, Y.Y., Tyurin, V.A., Jiang, J., Stoyanovsky, D.A., Wipf, P., Kochanek, P.M., Greenberger, J.S., Pitt, B., Shvedova, A.A., & Borisenko, G. (2009). Cytochrome c/cardiolipin relations in mitochondria: a kiss of death. FREE RADICAL BIOLOGY AND MEDICINE, 46(11), 1439-1453.Elsevier BV. doi: 10.1016/j.freeradbiomed.2009.03.004.

Kagan, V.E., Wipf, P., Stoyanovsky, D., Greenberger, J.S., Borisenko, G., Belikova, N.A., Yanamala, N., Arias, A.K.S., Tungekar, M.A., Jiang, J., Tyurina, Y.Y., Ji, J., Klein-Seetharaman, J., Pitt, B.R., Shvedova, A.A., & Bayir, H. (2009). Mitochondrial targeting of electron scavenging antioxidants: Regulation of selective oxidation vs random chain reactions. ADVANCED DRUG DELIVERY REVIEWS, 61(14), 1375-1385.Elsevier BV. doi: 10.1016/j.addr.2009.06.008.

Li, J., Wilson, A., Gao, X., Kuruba, R., Liu, Y., Poloyac, S., Pitt, B., Xie, W., & Li, S. (2009). Coordinated Regulation of Dimethylarginine Dimethylaminohydrolase-1 and Cationic Amino Acid Transporter-1 by Farnesoid X Receptor in Mouse Liver and Kidney and Its Implication in the Control of Blood Levels of Asymmetric Dimethylarginine. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 331(1), 234-243.American Society for Pharmacology & Experimental Therapeutics (ASPET). doi: 10.1124/jpet.109.153510.

Nemec, A.A., Leikauf, G.D., Pitt, B.R., Wasserloos, K.J., & Barchowsky, A. (2009). Nickel Mobilizes Intracellular Zinc to Induce Metallothionein in Human Airway Epithelial Cells. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 41(1), 69-75.American Thoracic Society. doi: 10.1165/rcmb.2008-0409OC.

Tyurin, V.A., Tyurina, Y., Jung, M.Y., Tungekar, M.A., Wasserloos, K.J., Bayir, H., Greenberger, J.S., Kochanek, P.M., Shvedova, A.A., Pitt, B., & Kagan, V.E. (2009). Mass-spectrometric analysis of hydroperoxy- and hydroxy-derivatives of cardiolipin and phosphatidylserine in cells and tissues induced by pro-apoptotic and pro-inflammatory stimuli. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 877(26), 2863-2872.Elsevier BV. doi: 10.1016/j.jchromb.2009.03.007.

Bernal, P.J., Leelavanichkul, K., Bauer, E., Cao, R., Wilson, A., Wasserloos, K.J., Watkins, S.C., Pitt, B.R., & St Croix, C.M. (2008). Nitric oxide-mediated zinc release contributes to hypoxic regulation of pulmonary vascular tone. CIRCULATION RESEARCH, 102(12), 1575-1583.Ovid Technologies (Wolters Kluwer Health). doi: 10.1161/CIRCRESAHA.108.171264.

Fattman, C.L., Gambelli, F., Hoyle, G., Pitt, B.R., & Ortiz, L.A. (2008). Epithelial expression of TIMP-1 does not alter sensitivity to bleomycin-induced lung injury in C57BL/6 mice. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 294(3), L572-L581.American Physiological Society. doi: 10.1152/ajplung.00291.2007.

Kaynar, A.M., Houghton, A.M., Lum, E.H., Pitt, B.R., & Shapiro, S.D. (2008). Neutrophil elastase is needed for neutrophil emigration into lungs in ventilator-induced lung injury. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 39(1), 53-60.American Thoracic Society. doi: 10.1165/rcmb.2007-0315OC.

Kleinschmidt, A.M., Nassiri, M., Stitt, M.S., Wasserloos, K., Watkins, S.C., Pitt, B.R., & Jahroudi, N. (2008). Sequences in intron 51 of the von Willebrand factor gene target promoter activation to a subset of lung endothelial cells in transgenic mice. JOURNAL OF BIOLOGICAL CHEMISTRY, 283(5), 2741-2750.Elsevier BV. doi: 10.1074/jbc.M705466200.

Li, J., Wilson, A., Kuruba, R., Zhang, Q., Gao, X., He, F., Zhang, L.M., Pitt, B.R., Xie, W., & Li, S. (2008). FXR-mediated regulation of eNOS expression in vascular endothelial cells. CARDIOVASCULAR RESEARCH, 77(1), 169-177.Oxford University Press (OUP). doi: 10.1093/cvr/cvm016.

Zhang, Q., He, F., Kuruba, R., Gao, X., Wilson, A., Li, J., Billiar, T.R., Pitt, B.R., Xie, W., & Li, S. (2008). FXR-mediated regulation of angiotensin type 2 receptor expression in vascular smooth muscle cells. CARDIOVASCULAR RESEARCH, 77(3), 560-569.Oxford University Press (OUP). doi: 10.1093/cvr/cvm068.

Tyurina, Y.Y., Basova, L.V., Konduru, N.V., Tyurin, V.A., Potapovich, A.I., Cai, P., Bayir, H., Stoyanovsky, D., Pitt, B.R., Shvedova, A.A., Fadeel, B., & Kagan, V.E. (2007). Nitrosative stress inhibits the aminophospholipid translocase resulting in phosphatidylserine externalization and macrophage engulfment - Implications for the resolution of inflammation. JOURNAL OF BIOLOGICAL CHEMISTRY, 282(11), 8498-8509.Elsevier BV. doi: 10.1074/jbc.M606950200.

He, F.T., Li, J., Mu, Y., Kuruba, R., Ma, Z., Wilson, A., Alber, S., Jiang, Y., Stevens, T., Watkins, S., Pitt, B., Xie, W., & Li, S. (2006). Downregulation of endothelin-1 by farnesoid X receptor in vascular endothelial cells. CIRCULATION RESEARCH, 98(2), 192-199.Ovid Technologies (Wolters Kluwer Health). doi: 10.1161/01.RES.0000200400.55539.85.

Matthay, M.A., Christman, J.W., Pitt, B.R., Schwiebert, L.M., Stevens, T., & Ware, L.B. (2006). Perspectives, translational research, and letters to the editor. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 290(4), L621.American Physiological Society. doi: 10.1152/ajplung.00003.2006.

Stitt, M.S., Wasserloos, K.J., Tang, X., Liu, X., Pitt, B.R., & St Croix, C.M. (2006). Nitric oxide-induced nuclear translocation of the metal responsive transcription factor, MTF-1 is mediated by zinc release from metallothionein. VASCULAR PHARMACOLOGY, 44(3), 149-155.Elsevier BV. doi: 10.1016/j.vph.2005.10.004.

Zhang, L.M., Croix, C.S., Cao, R., Wasserloos, K., Watkins, S.C., Stevens, T., Li, S., Tyurin, V., Kagan, V.E., & Pitt, B.R. (2006). Cell-surface protein disulfide isomerase is reauired for transnitrosation of metallothionein by S-nitroso-albumin in intact rat pulmonary vascular endothelial cells. EXPERIMENTAL BIOLOGY AND MEDICINE, 231(9), 1507-1515.Frontiers Media SA. doi: 10.1177/153537020623100909.

Gandley, R.E., Tyurin, V.A., Huang, W., Arroyo, A., Daftary, A., Harger, G., Jiang, J.F., Pitt, B., Taylor, R.N., Hubel, C.A., & Kagan, V.E. (2005). S-nitrosoalbumin-mediated relaxation is enhanced by ascorbate and copper -: Effects in pregnancy and preeclampsia plasma. HYPERTENSION, 45(1), 21-27.Ovid Technologies (Wolters Kluwer Health). doi: 10.1161/01.HYP.0000150158.42620.3e.

Ma, Z., Li, J., He, F.T., Wilson, A., Pitt, B., & Li, S. (2005). Cationic lipids enhance siRNA-mediated interferon response in mice. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 330(3), 755-759.Elsevier BV. doi: 10.1016/j.bbrc.2005.03.041.

St Croix, C.M., Leelavaninchkul, K., Watkins, S.C., Kagan, V.E., & Pitt, B.R. (2005). Nitric oxide and zinc homeostasis in acute lung injury. Proc Am Thorac Soc, 2(3), 236-242.American Thoracic Society. doi: 10.1513/pats.200501-007AC.

St Croix, C.M., Pitt, B.R., & Watkins, S.C. (2005). The use of contemporary fluorescent imaging technologies in biomedical research. Medicine and Science, 10(1), 16-29.

St Croix, C.M., Stitt, M.S., Watkins, S.C., & Pitt, B.R. (2005). Fluorescence resonance energy transfer-based assays for the real-time detection of nitric oxide signaling. NITRIC OXIDE, PT E, 396, 317-+.Elsevier. doi: 10.1016/S0076-6879(05)96026-6.

Stoyanovsky, D.A., Tyurina, Y.Y., Tyurin, V.A., Anand, D., Mandavia, D.N., Gius, D., Ivanova, J., Pitt, B., Billiar, T.R., & Kagan, V.E. (2005). Thioredoxin and lipoic acid catalyze the denitrosation of low molecular weight and protein S-nitrosothiols. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 127(45), 15815-15823.American Chemical Society (ACS). doi: 10.1021/ja0529135.

Wilson, A., He, F., Li, J., Ma, Z., Pitt, B., & Li, S. (2005). Targeted Delivery of Therapeutic Oligonucleotides to Pulmonary Circulation. In NON-VIRAL VECTORS FOR GENE THERAPY, SECOND EDITION: PART 2. 54, (pp. 21-41).Elsevier. doi: 10.1016/S0065-2660(05)54002-1.

Wilson, A., He, F., Li, J., Ma, Z., Pitt, B., & Li, S. (2005). Targeted delivery of therapeutic oligonucleotides to pulmonary circulation. Adv Genet, 54, 21-41. doi: 10.1016/S0065-2660(05)54002-1.

Wilson, A., Zhou, W., Champion, H.C., Alber, S., Tang, Z.L., Kennel, S., Watkins, S., Huang, L., Pitt, B., & Li, S. (2005). Targeted delivery of oligodeoxynucleotides to mouse lung endothelial cells in vitro and in vivo. MOLECULAR THERAPY, 12(3), 510-518.Elsevier BV. doi: 10.1016/j.ymthe.2005.04.005.

Croix, C.M.S., Stitt, M.S., Leelavanichkul, K., Wasserloos, K.J., Pitt, B.R., & Watkins, S.C. (2004). Nitric oxide-induced modification of protein thiolate clusters as determined by spectral fluorescence resonance energy transfer in live endothelial cells. FREE RADICAL BIOLOGY AND MEDICINE, 37(6), 785-792.Elsevier BV. doi: 10.1016/j.freeradbiomed.2004.06.004.

Li, J., Ma, Z., Tang, Z.L., Stevens, T., Pitt, B., & Li, S. (2004). CpG DNA-mediated immune response in pulmonary endothelial cells. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 287(3), L552-L558.American Physiological Society. doi: 10.1152/ajplung.00436.2003.

Ma, Z., Li, J., Yang, L.J., Mu, Y., Xie, W., Pitt, B., & Li, S. (2004). Inhibition of LPS- and CpG DNA-induced TNF-α response by oxidized phospholipids. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 286(4), L808-L816.American Physiological Society. doi: 10.1152/ajplung.00220.2003.

Pitt, B.R., & Ortiz, L.A. (2004). Stem cells in lung biology. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 286(4), L621-L623.American Physiological Society. doi: 10.1152/ajplung.00392.2003.

Tyurina, Y.Y., Tyurin, V.A., Zhao, Q., Djukic, M., Quinn, P.J., Pitt, B.R., & Kagan, V.E. (2004). Oxidation of phosphatidylserine: a mechanism for plasma membrane phospholipid scrambling during apoptosis?. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 324(3), 1059-1064.Elsevier BV. doi: 10.1016/j.bbrc.2004.09.102.

Lawler, C., Suk, W.A., Pitt, B.R., St Croix, C.M., & Watkins, S.C. (2003). Multimodal optical imaging. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 285(2), L269-L280.American Physiological Society. doi: 10.1152/ajplung.00424.2002.

Zhang, J., Wilson, A., Alber, S., Ma, Z., Tang, Z.L., Satoh, E., Mazda, O., Watkins, S., Huang, L., Pitt, B., & Li, S. (2003). Prolonged gene expression in mouse lung endothelial cells following transfection with Epstein-Barr virus-based episomal plasmid. GENE THERAPY, 10(9), 822-826.Springer Science and Business Media LLC. doi: 10.1038/sj.gt.3301958.

Fabisiak, J.P., Borisenko, G.G., Liu, S.X., Tyurin, V.A., Pitt, B.R., & Kagan, V.E. (2002). Redox sensor function of metallothioneins. REDOX CELL BIOLOGY AND GENETICS, PT B, 353, 268-281.Elsevier. doi: 10.1016/s0076-6879(02)53055-x.

Jiang, J.F., St Croix, C.M., Sussman, N., Zhao, Q., Pitt, B.R., & Kagan, V.E. (2002). Contribution of glutathione and metallothioneins to protection against copper toxicity and redox cycling: quantitative analysis using MT+/+ and MT-/- mouse lung fibroblast cells. CHEMICAL RESEARCH IN TOXICOLOGY, 15(8), 1080-1087.American Chemical Society (ACS). doi: 10.1021/tx020022u.

Ma, Z., Mi, Z., Wilson, A., Alber, S., Robbins, P.D., Watkins, S., Pitt, B., & Li, S. (2002). Redirecting adenovirus to pulmonary endothelium by cationic liposomes. Gene Ther, 9(3), 176-182.Springer Science and Business Media LLC. doi: 10.1038/sj.gt.3301636.

Ma, Z., Zhang, J., Alber, S., Dileo, J., Negishi, Y., Stolz, D., Watkins, S., Huang, L., Pitt, B., & Li, S. (2002). Lipid-mediated delivery of oligonucleotide to pulmonary endothelium. Am J Respir Cell Mol Biol, 27(2), 151-159.American Thoracic Society. doi: 10.1165/ajrcmb.27.2.4653.

Pearce, L.L., Kanai, A.J., Birder, L.A., Pitt, B.R., & Peterson, J. (2002). The catabolic fate of nitric oxide - The nitric oxide oxidase and peroxynitrite reductase activities of cytochrome oxidase. JOURNAL OF BIOLOGICAL CHEMISTRY, 277(16), 13556-13562.Elsevier BV. doi: 10.1074/jbc.M109838200.

Pitt, B.R., & St Croix, C.M. (2002). Complex regulation of iNOS in lung. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 26(1), 6-9.American Thoracic Society. doi: 10.1165/ajrcmb.26.1.f224.

St Croix, C.M., Wasserloos, K.J., Dineley, K.E., Reynolds, I.J., Levitan, E.S., & Pitt, B.R. (2002). Nitric oxide-induced changes in intracellular zinc homeostasis are mediated by metallothionein/thionein. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 282(2), L185-L192.American Physiological Society. doi: 10.1152/ajplung.00267.2001.

Tang, Z.L., Wasserloos, K.J., Liu, X., Stitt, M.S., Reynolds, I.J., Pitt, B.R., & St Croix, C.M. (2002). Nitric oxide decreases the sensitivity of pulmonary endothelial cells to LPS-induced apoptosis in a zinc-dependent fashion. Mol Cell Biochem, 234-235(1-2), 211-217. doi: 10.1023/A:1015930927407.

Wilson, A., Pitt, B., & Li, S. (2002). Complex roles of CpG in liposomal delivery of DNA and oligonucleotides. BIOSCIENCE REPORTS, 22(2), 309-322.Portland Press Ltd. doi: 10.1023/A:1020146924504.

Zhou, W., Yuan, X., Wilson, A., Yang, L.J., Mokotoff, M., Pitt, B., & Li, S. (2002). Efficient intracellular delivery of oligonucleotides formulated in folate receptor-targeted lipid vesicles. BIOCONJUGATE CHEMISTRY, 13(6), 1220-1225.American Chemical Society (ACS). doi: 10.1021/bc025569z.

Finder, J.D., Petrus, J.L., Hamilton, A., Villavicencio, R.T., Pitt, B.R., & Sebti, S.M. (2001). Signal transduction pathways of IL-1β-mediated iNOS in pulmonary vascular smooth muscle cells. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 281(4), L816-L823.American Physiological Society. doi: 10.1152/ajplung.2001.281.4.L816.

Hauser, G.J., Wasserloos, K., Dayao, E.K., & Pitt, B.R. (2001). Effect of sodium arsenite on iNOS expression and vascular hyporeactivity associated with cecal ligation and puncture in the rat. Shock, 15(1), 73-76.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/00024382-200115010-00012.

Liu, S.X., Kawai, K., Tyurin, V.A., Tyurina, Y.Y., Borisenko, G.G., Fabisiak, J.P., Quinn, P.J., Pitt, B.R., & Kagan, V.E. (2001). Nitric oxide-dependent pro-oxidant and pro-apoptotic effect of metallothioneins in HL-60 cells challenged with cupric nitrilotriacetate. BIOCHEMICAL JOURNAL, 354(Pt 2), 397-406.Portland Press Ltd. doi: 10.1042/0264-6021:3540397.

Pearce, L.L., Epperly, M.W., Greenberger, J.S., Pitt, B.R., & Peterson, J. (2001). Identification of respiratory complexes I and III as mitochondrial sites of damage following exposure to ionizing radiation and nitric oxide. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 5(2), 128-136.Elsevier BV. doi: 10.1006/niox.2001.0338.

Pitt, B.R. (2001). CFTR trafficking and signaling in respiratory epithelium. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 281(1), L13-L15.American Physiological Society. doi: 10.1152/ajplung.2001.281.1.L13.

Tang, Z.L., Wasserloos, K., St Croix, C.M., & Pitt, B.R. (2001). Role of zinc in pulmonary endothelial cell response to oxidative stress. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 281(1), L243-L249.American Physiological Society. doi: 10.1152/ajplung.2001.281.1.L243.

Boota, A., Johnson, B., Lee, K.L., Blaskovich, M.A., Liu, S.X., Kagan, V.E., Hamilton, A., Pitt, B., Sebti, S.M., & Davies, P. (2000). Prenyltransferase inhibitors block superoxide production by pulmonary vascular smooth muscle. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 278(2), L329-L334.American Physiological Society. doi: 10.1152/ajplung.2000.278.2.L329.

Erukhimov, J.A., Tang, Z.L., Johnson, B.A., Donahoe, M.P., Razzack, J.A., Gibson, K.F., Lee, W.M., Wasserloos, K.J., Watkins, S.A., & Pitt, B.R. (2000). Actin-containing sera from patients with adult respiratory distress syndrome are toxic to sheep pulmonary endothelial cells. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 162(1), 288-294.American Thoracic Society. doi: 10.1164/ajrccm.162.1.9806088.

Johnson, B.A., Pitt, B.R., & Davies, P. (2000). Pulmonary arterial smooth muscle cells modulate cytokine- and LPS-induced cytotoxicity in endothelial cells. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 278(3), L460-L468.American Physiological Society. doi: 10.1152/ajplung.2000.278.3.L460.

Kawai, K., Liu, S.X., Tyurin, V.A., Tyurina, Y.Y., Borisenko, G.G., Jiang, J.F., St Croix, C.M., Fabisiak, J.P., Pitt, B.R., & Kagan, V.E. (2000). Antioxidant and antiapoptotic function of metallothioneins in HL-60 cells challenged with copper nitrilotriacetate. CHEMICAL RESEARCH IN TOXICOLOGY, 13(12), 1275-1286.American Chemical Society (ACS). doi: 10.1021/tx000119l.

Li, S., Tan, Y., Viroonchatapan, E., Pitt, B.R., & Huang, L. (2000). Targeted gene delivery to pulmonary endothelium by anti-PECAM antibody. Am J Physiol Lung Cell Mol Physiol, 278(3), L504-L511.American Physiological Society. doi: 10.1152/ajplung.2000.278.3.L504.

Liu, S.X., Fabisiak, J.P., Tyurin, V.A., Borisenko, G.G., Pitt, B.R., Lazo, J.S., & Kagan, V.E. (2000). Reconstitution of apo-superoxide dismutase by nitric oxide-induced copper transfer from metallothioneins. CHEMICAL RESEARCH IN TOXICOLOGY, 13(9), 922-931.American Chemical Society (ACS). doi: 10.1021/tx0000623.

Merker, M.P., Pitt, B.R., Choi, A.M., Hassoun, P.M., Dawson, C.A., & Fisher, A.B. (2000). Lung redox homeostasis: emerging concepts. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 279(3), L413-L417.American Physiological Society. doi: 10.1152/ajplung.2000.279.3.L413.

Pearce, L.L., Gandley, R.E., Han, W.P., Wasserloos, K., Stitt, M., Kanai, A.J., McLaughlin, M.K., Pitt, B.R., & Levitan, E.S. (2000). Role of metallothionein in nitric oxide signaling as revealed by a green fluorescent fusion protein. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 97(1), 477-482.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.97.1.477.

Pearce, L.L., Wasserloos, K., St Croix, C.M., Gandley, R., Levitan, E.S., & Pitt, B.R. (2000). Metallothionein, nitric oxide and zinc homeostasis in vascular endothelial cells. J Nutr, 130(5S Suppl), 1467S-1470S.Elsevier BV. doi: 10.1093/jn/130.5.1467S.

Schwarz, M.A., Zhang, F.R., Lane, J.E., Schachtner, S., Jin, Y., Deutsch, G., Starnes, V., & Pitt, B.R. (2000). Angiogenesis and morphogenesis of murine fetal distal lung in an allograft model. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 278(5), L1000-L1007.American Physiological Society. doi: 10.1152/ajplung.2000.278.5.L1000.

Villavicencio, R.T., Liu, S.B., Kibbe, M.R., Williams, D.L., Ganster, R.W., Dyer, K.F., Tweardy, D.J., Billiar, T.R., & Pitt, B.R. (2000). Induced nitric oxide inhibits IL-6-induced Stat3 activation and type II acute phase mRNA expression. SHOCK, 13(6), 441-445.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/00024382-200006000-00004.

Davidge, S.T., Pitt, B.R., McLaughlin, M.K., Roberts, J.M., & Johnson, B.A. (1999). Biphasic stimulation of prostacyclin by endogenous nitric oxide (NO) in endothelial cells transfected with inducible NO synthase. GENERAL PHARMACOLOGY, 33(5), 383-387.Elsevier BV. doi: 10.1016/S0306-3623(99)00033-6.

Fabisiak, J.P., Pearce, L.L., Borisenko, G.G., Tyurina, Y.Y., Tyurin, V.A., Razzack, J., Lazo, J.S., Pitt, B.R., & Kagan, V.E. (1999). Bifunctional Anti-/Prooxidant Potential of Metallothionein: Redox Signaling of Copper Binding and Release. ANTIOXIDANTS & REDOX SIGNALING, 1(3), 349-U60.Mary Ann Liebert Inc. doi: 10.1089/ars.1999.1.3-349.

Fabisiak, J.P., Tyurin, V.A., Tyurina, Y.Y., Borisenko, G.G., Korotaeva, A., Pitt, B.R., Lazo, J.S., & Kagan, V.E. (1999). Redox regulation of copper-metallothionein. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 363(1), 171-181.Elsevier BV. doi: 10.1006/abbi.1998.1077.

Li, S., Wu, S.P., Whitmore, M., Loeffert, E.J., Wang, L., Watkins, S.C., Pitt, B.R., & Huang, L. (1999). Effect of immune response on gene transfer to the lung via systemic administration of cationic lipidic vectors. Am J Physiol, 276(5), L796-L804.American Physiological Society. doi: 10.1152/ajplung.1999.276.5.L796.

Pearce, L.L., Pitt, B.R., & Peterson, J. (1999). The peroxynitrite reductase activity of cytochrome c oxidase involves a two-electron redox reaction at the heme a3-CuB site. JOURNAL OF BIOLOGICAL CHEMISTRY, 274(50), 35763-35767.Elsevier BV. doi: 10.1074/jbc.274.50.35763.

Tan, Y.D., Li, S., Pitt, B.R., & Huang, L. (1999). The inhibitory role of CpG immunostimulatory motifs in cationic lipid vector-mediated transgene expression in vivo. HUMAN GENE THERAPY, 10(13), 2153-2161.Mary Ann Liebert Inc. doi: 10.1089/10430349950017149.

Ceneviva, G.D., Tzeng, E., Hoyt, D.G., Yee, E., Gallagher, A., Engelhardt, J.F., Kim, Y.M., Billiar, T.R., Watkins, S.A., & Pitt, B.R. (1998). Nitric oxide inhibits lipopolysaccharide-induced apoptosis in pulmonary artery endothelial cells. Am J Physiol, 275(4), L717-L728.American Physiological Society. doi: 10.1152/ajplung.1998.275.4.L717.

Lazo, J.S., Kuo, S.M., Woo, E.S., & Pitt, B.R. (1998). The protein thiol metallothionein as an antioxidant and protectant against antineoplastic drugs. CHEMICO-BIOLOGICAL INTERACTIONS, 112, 255-262.Elsevier BV. doi: 10.1016/S0009-2797(97)00165-8.

Stark, W.W., Blaskovich, M.A., Johnson, B.A., Qian, Y., Vasudevan, A., Pitt, B., Hamilton, A.D., Sebti, S.M., & Davies, P. (1998). Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells. Am J Physiol, 275(1), L55-L63.American Physiological Society. doi: 10.1152/ajplung.1998.275.1.L55.

Hoyt, D.G., Rizzo, M., Gerritsen, M.E., Pitt, B.R., & Lazo, J.S. (1997). Integrin activation protects pulmonary endothelial cells from the genotoxic effects of bleomycin. Am J Physiol, 273(3 Pt 1), L612-L617.American Physiological Society. doi: 10.1152/ajplung.1997.273.3.L612.

Kondo, Y., Rusnak, J.M., Hoyt, D.G., Settineri, C.E., Pitt, B.R., & Lazo, J.S. (1997). Enhanced apoptosis in metallothionein null cells. MOLECULAR PHARMACOLOGY, 52(2), 195-201.American Society for Pharmacology & Experimental Therapeutics (ASPET). doi: 10.1124/mol.52.2.195.

Pitt, B.R., Schwarz, M., Woo, E.S., Yee, E., Wasserloos, K., Tran, S., Weng, W., Mannix, R.J., Watkins, S.A., Tyurina, Y.Y., Tyurin, V.A., Kagan, V.E., & Lazo, J.S. (1997). Overexpression of metallothionein decreases sensitivity of pulmonary endothelial cells to oxidant injury. Am J Physiol, 273(4), L856-L865.American Physiological Society. doi: 10.1152/ajplung.1997.273.4.L856.

Tzeng, E., Kim, Y.M., Pitt, B.R., Lizonova, A., Kovesdi, I., & Billiar, T.R. (1997). Adenoviral transfer of the inducible nitric oxide synthase gene blocks endothelial cell apoptosis. SURGERY, 122(2), 255-263.Elsevier BV. doi: 10.1016/S0039-6060(97)90016-7.

Hauser, G.J., Dayao, E.K., Wasserloos, K., Pitt, B.R., & Wong, H.R. (1996). HSP induction inhibits iNOS mRNA expression and attenuates hypotension in endotoxin-challenged rats. Am J Physiol, 271(6 Pt 2), H2529-H2535.American Physiological Society. doi: 10.1152/ajpheart.1996.271.6.H2529.

Pitt, B.R., & Robbins, P.D. (1996). Retrovirus-mediated gene therapy to fetal lung. Mol Hum Reprod, 2(7), 467-469.Oxford University Press (OUP). doi: 10.1093/molehr/2.7.467.

Wong, H.R., Mannix, R.J., Rusnak, J.M., Boota, A., Zar, H., Watkins, S.C., Lazo, J.S., & Pitt, B.R. (1996). The heat-shock response attenuates lipopolysaccharide-mediated apoptosis in cultured sheep pulmonary artery endothelial cells. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 15(6), 745-751.American Thoracic Society. doi: 10.1165/ajrcmb.15.6.8969269.



Wong, H.R., Finder, J.D., Wasserloos, K., & Pitt, B.R. (1995). Expression of iNOS in cultured rat pulmonary artery smooth muscle cells is inhibited by the heat shock response. Am J Physiol, 269(6 Pt 1), L843-L848.American Physiological Society. doi: 10.1152/ajplung.1995.269.6.L843.


Nakayama, D.K., Geller, D.A., Di Silvio, M., Bloomgarden, G., Davies, P., Pitt, B.R., Hatakeyama, K., Kagamiyama, H., Simmons, R.L., & Billiar, T.R. (1994). Tetrahydrobiopterin synthesis and inducible nitric oxide production in pulmonary artery smooth muscle. Am J Physiol, 266(4 Pt 1), L455-L460.American Physiological Society. doi: 10.1152/ajplung.1994.266.4.L455.



Yeates, D.B., Spektor, D.M., Leikauf, G.D., & Pitt, B.R. (1981). Effects of drugs on mucociliary transport in the trachea and bronchial airways. Chest, 80(6 Suppl), 870-873. doi: 10.1378/chest.80.6.870.