Fabrisia Ambrosio

Associate Professor
Bioengineering Department


Clemens, Z., Sivakumar, S., Pius, A., Sahu, A., Shinde, S., Mamiya, H., Luketich, N., Cui, J., Dixit, P., Hoeck, J.D., Kreuz, S., Franti, M., Barchowsky, A., & Ambrosio, F. (2021). The biphasic and age-dependent impact of klotho on hallmarks of aging and skeletal muscle function. ELIFE, 10.eLife Sciences Publications, Ltd. doi: 10.7554/eLife.61138.

Kakar, R.S., Pastor, J.V., Moe, O.W., Ambrosio, F., Castaldi, D., & Sanders, L.H. (2021). Peripheral Klotho and Parkinson's Disease. MOVEMENT DISORDERS, 36(5), 1274-1276.Wiley. doi: 10.1002/mds.28530.

Anguiano, T., Sahu, A., Qian, B., Tang, W.Y., Ambrosio, F., & Barchowsky, A. (2020). Arsenic Directs Stem Cell Fate by Imparting Notch Signaling Into the Extracellular Matrix Niche. TOXICOLOGICAL SCIENCES, 177(2), 494-505.Oxford University Press (OUP). doi: 10.1093/toxsci/kfaa106.

Cheikhi, A., Anguiano, T., Lasak, J., Qian, B., Sahu, A., Mimiya, H., Cohen, C.C., Wipf, P., Ambrosio, F., & Barchowsky, A. (2020). Arsenic Stimulates Mycblast Mitochondrial Epidermal Growth Factor Receptor to Impair Myogenesis. TOXICOLOGICAL SCIENCES, 176(1), 162-174.Oxford University Press (OUP). doi: 10.1093/toxsci/kfaa031.

Sachdev, U., Ferrari, R., Cui, X., Pius, A., Sahu, A., Reynolds, M., Liao, H., Sun, P., Shinde, S., Ambrosio, F., Shiva, S., Loughran, P., & Scott, M. (2020). Caspase1/11 signaling affects muscle regeneration and recovery following ischemia, and can be modulated by chloroquine. MOLECULAR MEDICINE, 26(1), 69.Springer Science and Business Media LLC. doi: 10.1186/s10020-020-00190-2.

Willett, N.J., Boninger, M.L., Miller, L.J., Alvarez, L., Aoyama, T., Bedoni, M., Brix, K.A., Chisari, C., Christ, G., Dearth, C.L., Dyson-Hudson, T.A., Evans, C.H., Goldman, S.M., Gregory, K., Gualerzi, A., Hart, J., Ito, A., Kuroki, H., Loghmani, M.T., Mack, D.L., Malanga, G.A., Noble-Haeusslein, L., Pasquina, P., Roche, J.A., Rose, L., Stoddart, M.J., Tajino, J., Terzic, C., Topp, K.S., Wagner, W.R., Warden, S.J., Wolf, S.L., Xie, H., Rando, T.A., & Ambrosio, F. (2020). Taking the Next Steps in Regenerative Rehabilitation: Establishment of a New Interdisciplinary Field. ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION, 101(5), 917-923.Elsevier BV. doi: 10.1016/j.apmr.2020.01.007.

Cheikhi, A., Barchowsky, A., Sahu, A., Shinde, S.N., Pius, A., Clemens, Z.J., Li, H., Kennedy, C.A., Hoeck, J.D., Franti, M., & Ambrosio, F. (2019). Klotho: An Elephant in Aging Research. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 74(7), 1031-1042.Oxford University Press (OUP). doi: 10.1093/gerona/glz061.

Cheikhi, A., Wallace, C., St Croix, C., Cohen, C., Tang, W.Y., Wipf, P., Benos, P.V., Ambrosio, F., & Barchowsky, A. (2019). Mitochondria are a substrate of cellular memory. FREE RADICAL BIOLOGY AND MEDICINE, 130, 528-541.Elsevier BV. doi: 10.1016/j.freeradbiomed.2018.11.028.

Ambrosio, F., & Rando, T.A. (2018). The regenerative rehabilitation collection: a forum for an emerging field. NPJ REGENERATIVE MEDICINE, 3(1), 20.Springer Science and Business Media LLC. doi: 10.1038/s41536-018-0058-z.

Hartman, R., Patil, P., Tisherman, R., St Croix, C., Niedernhofer, L.J., Robbins, P.D., Ambrosio, F., Van Houten, B., Sowa, G., & Vo, N. (2018). AGE-DEPENDENT CHANGES IN INTERVERTEBRAL DISC CELL MITOCHONDRIA AND BIOENERGETICS. EUROPEAN CELLS & MATERIALS, 36, 171-183.European Cells and Materials. doi: 10.22203/eCM.v036a13.

Rando, T.A., & Ambrosio, F. (2018). Regenerative Rehabilitation: Applied Biophysics Meets Stem Cell Therapeutics. CELL STEM CELL, 22(3), 306-309.Elsevier BV. doi: 10.1016/j.stem.2018.02.003.

Rando, T.A., & Ambrosio, F. (2018). Regenerative Rehabilitation: Applied Biophysics Meets Stem Cell Therapeutics. Cell Stem Cell, 22(4), 608.Elsevier BV. doi: 10.1016/j.stem.2018.03.010.

Sahu, A., Mamiya, H., Shinde, S.N., Cheikhi, A., Winter, L.L., Vo, N.V., Stolz, D., Roginskaya, V., Tang, W.Y., Croix, C.S., Sanders, L.H., Franti, M., Van Houten, B., Rando, T.A., Barchowsky, A., & Ambrosio, F. (2018). Age-related declines in alpha-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration. NATURE COMMUNICATIONS, 9(1), 4859.Springer Science and Business Media LLC. doi: 10.1038/s41467-018-07253-3.

Dalise, S., Cavalli, L., Ghuman, H., Wahlberg, B., Gerwig, M., Chisari, C., Ambrosio, F., & Modo, M. (2017). Biological effects of dosing aerobic exercise and neuromuscular electrical stimulation in rats. SCIENTIFIC REPORTS, 7(1), 10830.Springer Science and Business Media LLC. doi: 10.1038/s41598-017-11260-7.

Lai, S., Panarese, A., Lawrence, R., Boninger, M.L., Micera, S., & Ambrosio, F. (2017). A Murine Model of Robotic Training to Evaluate Skeletal Muscle Recovery after Injury. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 49(4), 840-847.Ovid Technologies (Wolters Kluwer Health). doi: 10.1249/MSS.0000000000001160.

Moritz, C.T., & Ambrosio, F. (2017). Regenerative Rehabilitation: Combining Stem Cell Therapies and Activity-Dependent Stimulation. PEDIATRIC PHYSICAL THERAPY, 29(3), S10-S15.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/PEP.0000000000000378.

Stearns-Reider, K.M., D'Amore, A., Beezhold, K., Rothrauff, B., Cavalli, L., Wagner, W.R., Vorp, D.A., Tsamis, A., Shinde, S., Zhang, C., Barchowsky, A., Rando, T.A., Tuan, R.S., & Ambrosio, F. (2017). Aging of the skeletal muscle extracellular matrix drives a stem cell fibrogenic conversion. AGING CELL, 16(3), 518-528.Wiley. doi: 10.1111/acel.12578.

Ambrosio, F., & Kleim, J.A. (2016). Regenerative Rehabilitation and Genomics: Frontiers in Clinical Practice. PHYSICAL THERAPY, 96(4), 430-431.Oxford University Press (OUP). doi: 10.2522/ptj.2016.96.4.430.

Badylak, S.F., Dziki, J.L., Sicari, B.M., Ambrosio, F., & Boninger, M.L. (2016). Mechanisms by which acellular biologic scaffolds promote functional skeletal muscle restoration. BIOMATERIALS, 103, 128-136.Elsevier BV. doi: 10.1016/j.biomaterials.2016.06.047.

Han, N., Yabroudi, M.A., Stearns-Reider, K., Helkowski, W., Sicari, B.M., Rubin, J.P., Badylak, S.F., Boninger, M.L., & Ambrosio, F. (2016). Electrodiagnostic Evaluation of Individuals Implanted With Extracellular Matrix for the Treatment of Volumetric Muscle Injury: Case Series. PHYSICAL THERAPY, 96(4), 540-549.Oxford University Press (OUP). doi: 10.2522/ptj.20150133.

Ross, H.H., Ambrosio, F., Trumbower, R.D., Reier, P.J., Behrman, A.L., & Wolf, S.L. (2016). Neural Stem Cell Therapy and Rehabilitation in the Central Nervous System: Emerging Partnerships. PHYSICAL THERAPY, 96(5), 734-742.Oxford University Press (OUP). doi: 10.2522/ptj.20150063.

Zhang, C., Ferrari, R., Beezhold, K., Stearns-Reider, K., D'Amore, A., Haschak, M., Stolz, D., Robbins, P.D., Barchowsky, A., & Ambrosio, F. (2016). Arsenic Promotes NF-Kb-Mediated Fibroblast Dysfunction and Matrix Remodeling to Impair Muscle Stem Cell Function. STEM CELLS, 34(3), 732-742.Wiley. doi: 10.1002/stem.2232.

Ambrosio, F., Brown, E., Stolz, D., Ferrari, R., Goodpaster, B., Deasy, B., Distefano, G., Roperti, A., Cheikhi, A., Garciafigueroa, Y., & Barchowsky, A. (2014). Arsenic induces sustained impairment of skeletal muscle and muscle progenitor cell ultrastructure and bioenergetics. FREE RADICAL BIOLOGY AND MEDICINE, 74, 64-73.Elsevier BV. doi: 10.1016/j.freeradbiomed.2014.06.012.

Avin, K.G., Coen, P.M., Huang, W., Stolz, D.B., Sowa, G.A., Dube, J.J., Goodpaster, B.H., O'Doherty, R.M., & Ambrosia, F. (2014). Skeletal muscle as a regulator of the longevity protein, Klotho. FRONTIERS IN PHYSIOLOGY, 5, 189.Frontiers Media SA. doi: 10.3389/fphys.2014.00189.

Dalise, S., Ambrosio, F., & Modo, M. (2014). Adaptive plasticity and recovery in preclinical models of stroke. ARCHIVES ITALIENNES DE BIOLOGIE, 152(4), 190-215. doi: 10.12871/00039829201442.

Dalise, S., Ambrosio, F., & Modo, M. (2014). Brain plasticity and recovery in preclinical models of stroke. Arch Ital Biol, 152(4), 190-215. doi: 10.12871/00039829201442.

Gentile, N.E., Stearns, K.M., Brown, E.H.P., Rubin, J.P., Boninger, M.L., Dearth, C.L., Ambrosio, F., & Badylak, S.F. (2014). Targeted Rehabilitation After Extracellular Matrix Scaffold Transplantation for the Treatment of Volumetric Muscle Loss. AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION, 93(11), S79-S87.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/PHM.0000000000000145.

Sicari, B.M., Rubin, J.P., Dearth, C.L., Wolf, M.T., Ambrosio, F., Boninger, M., Turner, N.J., Weber, D.J., Simpson, T.W., Wyse, A., Brown, E.H.P., Dziki, J.L., Fisher, L.E., Brown, S., & Badylak, S.F. (2014). An Acellular Biologic Scaffold Promotes Skeletal Muscle Formation in Mice and Humans with Volumetric Muscle Loss. SCIENCE TRANSLATIONAL MEDICINE, 6(234), 234ra58.American Association for the Advancement of Science (AAAS). doi: 10.1126/scitranslmed.3008085.

Ambrosio, F., Boninger, M.L., Brubaker, C.E., Delitto, A., Wagner, W.R., Shields, R.K., Wolf, S.L., & Rando, T.A. (2013). Emergent themes from Second Annual Symposium on Regenerative Rehabilitation, Pittsburgh, Pennsylvania. JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT, 50(3), VII-XIII.Journal of Rehabilitation Research & Development. doi: 10.1682/JRRD.2013.04.0081.

Distefano, G., Ferrari, R.J., Weiss, C., Deasy, B.M., Boninger, M.L., Fitzgerald, G.K., Huard, J., & Ambrosio, F. (2013). Neuromuscular Electrical Stimulation as a Method to Maximize the Beneficial Effects of Muscle Stem Cells Transplanted into Dystrophic Skeletal Muscle. In Musaro, A. (Ed.). PLOS ONE, 8(3), e54922.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0054922.

Garciafigueroa, D.Y., Klei, L.R., Ambrosio, F., & Barchowsky, A. (2013). Arsenic-Stimulated Lipolysis and Adipose Remodeling Is Mediated by G-Protein-Coupled Receptors. TOXICOLOGICAL SCIENCES, 134(2), 335-344.Oxford University Press (OUP). doi: 10.1093/toxsci/kft108.

Kobayashi, T., Uehara, K., Ota, S., Tobita, K., Ambrosio, F., Cummins, J.H., Terada, S., Fu, F.H., & Huard, J. (2013). The timing of administration of a clinically relevant dose of losartan influences the healing process after contusion induced muscle injury. JOURNAL OF APPLIED PHYSIOLOGY, 114(2), 262-273.American Physiological Society. doi: 10.1152/japplphysiol.00140.2011.

Modo, M., Ambrosio, F., Friedlander, R.M., Badylak, S.F., & Wechsler, L.R. (2013). Bioengineering solutions for neural repair and recovery in stroke. CURRENT OPINION IN NEUROLOGY, 26(6), 626-631.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/WCO.0000000000000031.

Ambrosio, F., Fitzgerald, G.K., Ferrari, R., Distefano, G., & Carvell, G. (2012). A Murine Model of Muscle Training by Neuromuscular Electrical Stimulation. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (63), e3914.MyJove Corporation. doi: 10.3791/3914.

Childers, M.K., Markert, C., Atala, A., Cann, J., Christ, G., Furth, M., & Ambrosio, F. (2012). Regenerative medicine: Implications in rehabilitation. In DeLisa's Physical Medicine and Rehabilitation: Principles and Practice: Fifth Edition. 2-2, (pp. 2173-2186).

Ambrosio, F., Tarabishy, A., Kadi, F., Brown, E.H.P., & Sowa, G. (2011). Biological Basis of Exercise-Based Treatments for Musculoskeletal Conditions. PM&R, 3(6), S59-S63.Wiley. doi: 10.1016/j.pmrj.2011.05.001.

Ambrosio, F., Tarabishy, A., Kadi, F., Brown, E.H.P., & Sowa, G. (2011). Biological basis of exercise-based treatments for musculoskeletal conditions. PM & R : the journal of injury, function, and rehabilitation, 3(6 Suppl 1).

Markert, C.D., Ambrosio, F., Call, J.A., & Grange, R.W. (2011). EXERCISE AND DUCHENNE MUSCULAR DYSTROPHY: TOWARD EVIDENCE-BASED EXERCISE PRESCRIPTION. MUSCLE & NERVE, 43(4), 464-478.Wiley. doi: 10.1002/mus.21987.

Ambrosio, F., & Russell, A. (2010). Regenerative rehabilitation: a call to action. J Rehabil Res Dev, 47(3), xi-xv. doi: 10.1682/jrrd.2010.03.0021.

Ambrosio, F., Ferrari, R.J., Distefano, G., Plassmeyer, J.M., Carvell, G.E., Deasy, B.M., Boninger, M.L., Fitzgerald, G.K., & Huard, J. (2010). The Synergistic Effect of Treadmill Running on Stem-Cell Transplantation to Heal Injured Skeletal Muscle. TISSUE ENGINEERING PART A, 16(3), 839-849.Mary Ann Liebert Inc. doi: 10.1089/ten.tea.2009.0113.

Ambrosio, F., Wolf, S.L., Delitto, A., Fitzgerald, G.K., Badylak, S.F., Boninger, M.L., & Russell, A.J. (2010). The Emerging Relationship Between Regenerative Medicine and Physical Therapeutics. PHYSICAL THERAPY, 90(12), 1807-1814.Oxford University Press (OUP). doi: 10.2522/ptj.20100030.

Ambrosio, F., Ferrari, R.J., Fitzgerald, G.K., Carvell, G., Boninger, M.L., & Huard, J. (2009). Functional Overloading of Dystrophic Mice Enhances Muscle-Derived Stem Cell Contribution to Muscle Contractile Capacity. ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION, 90(1), 66-73.Elsevier BV. doi: 10.1016/j.apmr.2008.06.035.

Ambrosio, F., Kadi, F., Lexell, J., Fitzgerald, G.K., Boninger, M.L., & Huard, J. (2009). The Effect of Muscle Loading on Skeletal Muscle Regenerative Potential An Update of Current Research Findings Relating to Aging and Neuromuscular Pathology. AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION, 88(2), 145-155.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/PHM.0b013e3181951fc5.

Deasy, B.M., Feduska, J.M., Payne, T.R., Li, Y., Ambrosio, F., & Huard, J. (2009). Effect of VEGF on the Regenerative Capacity of Muscle Stem Cells in Dystrophic Skeletal Muscle. MOLECULAR THERAPY, 17(10), 1788-1798.Elsevier BV. doi: 10.1038/mt.2009.136.

Markert, C.D., Atala, A., Cann, J.K., Christ, G., Furth, M., Ambrosio, F., & Childers, M.K. (2009). Mesenchymal Stem Cells: Emerging Therapy for Duchenne Muscular Dystrophy. PM&R, 1(6), 547-559.Wiley. doi: 10.1016/j.pmrj.2009.02.013.

Nozaki, M., Li, Y., Zhu, J., Ambrosio, F., Uehara, K., Fu, F.H., & Huard, J. (2008). Improved Muscle Healing After Contusion Injury by the Inhibitory Effect of Suramin on Myostatin, a Negative Regulator of Muscle Growth. AMERICAN JOURNAL OF SPORTS MEDICINE, 36(12), 2354-2362.SAGE Publications. doi: 10.1177/0363546508322886.

Ambrosio, F., Boninger, M.L., Fitzgerald, S.G., Hubbard, S.L., Schwid, S.R., & Cooper, R.A. (2007). Comparison of mobility device delivery within Department of Veterans Affairs for individuals with multiple sclerosis versus spinal cord injury. JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT, 44(5), 693-701.Journal of Rehabilitation Research & Development. doi: 10.1682/JRRD.2006.02.0016.

Zhu, J., Li, Y., Shen, W., Qiao, C., Ambrosio, F., Lavasani, M., Nozaki, M., Branca, M.F., & Huard, J. (2007). Relationships between transforming growth factor-beta 1, myostatin, and decorin - Implications for skeletal muscle fibrosis. JOURNAL OF BIOLOGICAL CHEMISTRY, 282(35), 25852-25863.Elsevier BV. doi: 10.1074/jbc.M704146200.

Ambrosio, F., Boninger, M.L., Souza, A.L., Fitzgerald, S.G., Koontz, A.M., & Cooper, R.A. (2005). Biomechanics and strength of manual wheelchair users. JOURNAL OF SPINAL CORD MEDICINE, 28(5), 407-414.Informa UK Limited. doi: 10.1080/10790268.2005.11753840.

Souza, A.L., Boninger, M.L., Fitzgerald, S.G., Shimada, S.D., Cooper, R.A., & Ambrosio, F. (2005). Upper limb strength in individuals with spinal cord injury who use manual wheelchairs. JOURNAL OF SPINAL CORD MEDICINE, 28(1), 26-32.Informa UK Limited. doi: 10.1080/10790268.2005.11753795.

Koontz, A.M., Cooper, R.A., Arva, J., Buning, M.E., Souza, A.L., & Ambrosio, F. (2004). Strength and Disability. In Muscle Strength, Kumar, S. (Ed.). (pp. 485-518).CRC Press LLC.

Côté, C.H., Ambrosio, F., & Perreault, G. (1999). Metabolic and contractile influence of carbonic anhydrase III in skeletal muscle is age dependent. Am J Physiol, 276(2), R559-R565.American Physiological Society. doi: 10.1152/ajpregu.1999.276.2.R559.

Fay, B.T., Boninger, M.L., Ambrosio, F., & Cooper, R.A. (2003). Aspects of Fatigue in Multiple Sclerosis during Manual Wheelchair Propulsion. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 2, (pp. 1606-1608).