headshot

William Federspiel

Professor
John A Swanson Professor
Medical Devices Laboratory Bioengineering Department

about

(2019) Elected as National Academy of Inventors Fellow.

(2019) Appointed as John A. Swanson Professor.

(2019) 2019 Carnegie Science Award for Life Sciences.

(2018) Appointed to Editorial Board: Pediatric Research and Neonatal Care.

(2017) Appointed to Education Board, American Health Council.

(2016) Elected as an American Health Council Affiliate.

(2015) Invited by the Provost's and Chancellor's office to present my translational research experience to the University of Pittsburgh Board of Trustees in a talk entitled, "Respiratory Dialysis: A New Paradigm for Treating Lung Failure".

(2014) Certificate of Appreciation for Distinguished Service to the Rehabilitation Research and Development Service Scientific Merit Review Board from the Department of Veterans Affairs.

(2014) 2014 Carnegie Science Awards: Honorable Mention in the Start-Up Entrepreneur Award category.

(2014) Appointed to Honorary Editorial Board: Advanced Health Care Technologies.

(2014) ALung's Hemolung Respiratory Assist System (RAS) Recipient of Gold Award at Medical Design Excellence Awards.

(2013) Appointed to Editorial Board: Medical Instrumentation Journal.

(2011) Pitt Chronicle, featured in "Spotlight on Research: Charting the Future Through Bioengineering-Innovative ideas for lung disease and sepsis".

(2011) Member, American Institute for Medical Biological Engineering (AIMBE), Advocacy Committee.

(2011) Regular Member, Department of Veterans Affairs: Rehabilitation Research and Development Service.

(2010) Morning Journal, featured in "Emerging Technology May Help Patients Avoid Ventilators and Their Complications. Presented at: Morning Journal".

(2010) Top Ten MedGadget Award 2010: Alung's Hemolung Device.

(2009) Chair, Graduate Committee, Department of Bioengineering, University of Pittsburgh.

(2009 - 2013) Regular Member, NIH Study Section: Bioengineering, Technology and Surgical Sciences Study Section (BTSS).

(2008) Ad Hoc Member, NIH Study Section: Surgical Sciences, Biomedical Imaging and Bioengineering Integrated Review Group.

(2008) Appointed to Honorary Editorial Board: Medical Devices: Evidence and Research.

(2008) Chair, NIH Special Emphasis Review panel: Bioengineering Research Applications; Respiratory Sciences.

(2008) Appointed Member, International Scientific Advisory Committee for Biomed 2009.

(2007) New Scientist, featured in "A slimming treatment for artificial lungs".

(2007) Ad Hoc Member, NIH Study Section: Surgical Sciences, Biomedical Imaging and Bioengineering Integrated Review Group.

(2007) Elected Fellow, Biomedical Engineering Society (BMES).

(2007) Appointed to Editorial Board, Organogenesis.

(2006) Member, NIH Special Emphasis Panel: Bioengineering Research Applications: Respiratory.

(2006) Member, NIH Special Emphasis Panel: T1 Bioengineering Training Grants.

(2006) Member, NIH Special Emphasis Panel: BRP: Respiratory.

(2006) Member, NIH Special Emphasis Panel: Kidney Dialysis, Monitoring and Therapeutics.

(2006) Board of Visitors Award, School of Engineering, University Of Pittsburgh.

(2005) IEEE Spectrum, Profiled in story: "The Body Shops".

(2005) Appointed as William Kepler Whiteford Professor.

(2005) Ad Hoc Member, NIH Study Section, Vascular Cell and Molecular Biology.

(2005) Member, NIH Special Emphasis Review Panel: Bioengineering Research Applications: Respiratory Sciences.

(2004) Ad Hoc Member, NIH Study Section, Vascular Cell and Molecular Biology.

(2004) Appointed Section Editor, Bioengineering, ASAIO Journal.

(2003) World Technology Award for Health & Medicine, nominated.

(2003) Ad Hoc Member, NIH Study Section, Experimental Cardiovascular Services.

(2003 - 2005) Awarded CNG Faculty Fellowship, University of Pittsburgh.

(2002) Chemical and Engineering News, Profiled in story: "Pittsburgh Rising".

(2002) Invited Speaker: Pittsburgh Leadership Conference.

(2002) Ad Hoc Member, NIH Study Section, Experimental Cardiovascular Sciences.

(2002) Discover Magazine, featured in "100 top science stories of 2000".

(2001) New Scientist, featured in "Take a Breather".

(2001) USA Today, featured in "Artificial lung device holds breath of hope".

(2001) Ad Hoc Member, NIH Study Section, Surgery and Bioengineering.

(2001) Unrestricted Research Gift from Mallinckrodt Inc.: $25,000.

(2000) Ad Hoc Member, NIH Study Section, Lung Biology and Pathology.

(1999) Ad Hoc Member, NIH Study Section, Experimental Cardiovascular Sciences.

(1999) Ad Hoc Member, NIH Study Section, Surgery and Bioengineering.

(1999) Elected Fellow, American Institute for Medical and Biological Engineering.

(1998) Ad Hoc Member, NIH Study Section, Surgery and Bioengineering.

(1989) NIH Special Study Section Site Visit Team, RR01243, University of Washington.

(1986 - 1989) NIH New Investigator Research Award.

(1979 - 1982) NIH National Research Service Award.

(1978 - 1979) Shell Fellowship Award.

(1974 - 1978) Rochester Engineering Scholarship.

Ph.D., Chemical Engineering, University of Rochester, 1983

M.S., Chemical Engineering, University of Rochester, 1980

B.S., Chemical Engineering, University of Rochester, 1978

Orizondo, R.A., Omecinski, K.S., May, A.G., Dhamotharan, V., Frankowski, B.J., Burgreen, G.W., Ye, S.H., Kocyildirim, E., Sanchez, P.G., D'Cunha, J., Wagner, W.R., & Federspiel, W.J. (2021). Month-long Respiratory Support by a Wearable Pumping Artificial Lung in an Ovine Model. TRANSPLANTATION, 105(5), 999-1007.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/TP.0000000000003481.

Cove, M.E., Vu, L.H., Ring, T., Federspiel, W.J., & Kellum, J.A. (2020). Respiratory Dialysis-A Novel Low Bicarbonate Dialysate to Provide Extracorporeal Co(2)Removal. CRITICAL CARE MEDICINE, 48(7), E592-E598.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/CCM.0000000000004351.

May, A.G., Omecinski, K.S., Frankowski, B.J., & Federspiel, W.J. (2020). Effect of Hematocrit on the CO2 Removal Rate of Artificial Lungs. ASAIO J, 66(10), 1161-1165.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/MAT.0000000000001140.

May, A.G., Orizondo, R.A., Frankowski, B.J., Ye, S.H., Kocyildirim, E., Wagner, W.R., D'Cunha, J., & Federspiel, W.J. (2020). In vivo testing of the low-flow CO2 removal application of a compact, platform respiratory device. Intensive Care Med Exp, 8(1), 45.Springer Science and Business Media LLC. doi: 10.1186/s40635-020-00329-9.

Cove, M.E., Vu, L.H., Ring, T., May, A.G., Federspiel, W.J., & Kellum, J.A. (2019). A Proof of Concept Study, Demonstrating Extracorporeal Carbon Dioxide Removal Using Hemodialysis with a Low Bicarbonate Dialysate. ASAIO JOURNAL, 65(6), 605-613.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/MAT.0000000000000879.

Madhani, S.P., Frankowski, B.J., Ye, S.H., Burgreen, G.W., Wagner, W.R., Kormos, R., D'Cunha, J., & Federspiel, W.J. (2019). In Vivo 5 Day Animal Studies of a Compact, Wearable Pumping Artificial Lung. ASAIO JOURNAL, 65(1), 94-100.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/MAT.0000000000000740.

May, A.G., Orizondo, R.A., Frankowski, B.J., Wearden, P.D., & Federspiel, W.J. (2019). Acute In Vivo Evaluation of the Pittsburgh Pediatric Ambulatory Lung. ASAIO JOURNAL, 65(4), 395-400.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/MAT.0000000000000918.

Vu, L.H., Kellum, J.A., Federspiel, W.J., & Cove, M.E. (2019). Carbon dioxide removal using low bicarbonate dialysis in rodents. PERFUSION-UK, 34(7), 578-583.SAGE Publications. doi: 10.1177/0267659119839284.

Harter, T.S., May, A.G., Federspiel, W.J., Supuran, C.T., & Brauner, C.J. (2018). Time course of red blood cell intracellular pH recovery following short-circuiting in relation to venous transit times in rainbow trout, Oncorhynchus mykiss. Am J Physiol Regul Integr Comp Physiol, 315(2), R397-R407.American Physiological Society. doi: 10.1152/ajpregu.00062.2018.

Malkin, A.D., Ye, S.H., Lee, E.J., Yang, X., Zhu, Y., Gamble, L.J., Federspiel, W.J., & Wagner, W.R. (2018). Development of zwitterionic sulfobetaine block copolymer conjugation strategies for reduced platelet deposition in respiratory assist devices. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 106(7), 2681-2692.Wiley. doi: 10.1002/jbm.b.34085.

May, A.G., Jeffries, R.G., Frankowski, B.J., Burgreen, G.W., & Federspiel, W.J. (2018). Bench Validation of a Compact Low-Flow CO2 Removal Device. Intensive Care Med Exp, 6(1), 34.Springer Science and Business Media LLC. doi: 10.1186/s40635-018-0200-7.

Orizondo, R., Gino, G., Sultzbach, G., Madhani, S., Frankowski, B., & Federspiel, W. (2018). Effects of Hollow Fiber Membrane Oscillation on an Artificial Lung. Annals of Biomedical Engineering, 46(5), 762-771.Springer Verlag. doi: 10.1007/s10439-018-1995-9.

Orizondo, R.A., May, A.G., Madhani, S.P., Frankowski, B.J., Burgreen, G.W., Wearden, P.D., & Federspiel, W.J. (2018). In Vitro Characterization of the Pittsburgh Pediatric Ambulatory Lung. ASAIO JOURNAL, 64(6), 806-811.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/MAT.0000000000000711.

Jeffries, R.G., Lund, L., Frankowski, B., & Federspiel, W.J. (2017). An extracorporeal carbon dioxide removal (ECCO2R) device operating at hemodialysis blood flow rates. Intensive Care Med Exp, 5(1), 41.Springer Science and Business Media LLC. doi: 10.1186/s40635-017-0154-1.

Madhani, S.P., Frankowski, B.J., & Federspiel, W.J. (2017). Fiber Bundle Design for an Integrated Wearable Artificial Lung. ASAIO J, 63(5), 631-636.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/MAT.0000000000000542.

Madhani, S.P., Frankowski, B.J., Burgreen, G.W., Antaki, J.F., Kormos, R., D'Cunha, J., & Federspiel, W.J. (2017). In vitro and in vivo evaluation of a novel integrated wearable artificial lung. JOURNAL OF HEART AND LUNG TRANSPLANTATION, 36(7), 806-811.Elsevier BV. doi: 10.1016/j.healun.2017.02.025.

May, A.G., Sen, A., Cove, M.E., Kellum, J.A., & Federspiel, W.J. (2017). Extracorporeal CO2 removal by hemodialysis: in vitro model and feasibility. Intensive Care Med Exp, 5(1), 20.Springer Science and Business Media LLC. doi: 10.1186/s40635-017-0132-7.

Madhani, S.P., D'Aloiso, B.D., Frankowski, B., & Federspiel, W.J. (2016). Darcy Permeability of Hollow Fiber Membrane Bundles Made from Membrana Polymethylpentene Fibers Used in Respiratory Assist Devices. ASAIO JOURNAL, 62(3), 329-331.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/MAT.0000000000000348.

Nguyen, J., Malkin, A., & Federspiel, W. (2016). New chemical methods developed on prototypes with hopes to improve gas exchange within respiratory devices. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 251.

Parker, R.S., Hogg, J.S., Roy, A., Kellum, J.A., Rimmele, T., Daun-Gruhn, S., Fedorchak, M.V., Valenti, I.E., Federspiel, W.J., Rubin, J., Vodovotz, Y., Lagoa, C., & Clermont, G. (2016). Modeling and Hemofiltration Treatment of Acute Inflammation. PROCESSES, 4(4), 38.MDPI AG. doi: 10.3390/pr4040038.

Arazawa, D.T., Kimmel, J.D., & Federspiel, W.J. (2015). Kinetics of CO2 exchange with carbonic anhydrase immobilized on fiber membranes in artificial lungs. J Mater Sci Mater Med, 26(6), 193.Springer Science and Business Media LLC. doi: 10.1007/s10856-015-5525-0.

Arazawa, D.T., Kimmel, J.D., Finn, M.C., & Federspiel, W.J. (2015). Acidic sweep gas with carbonic anhydrase coated hollow fiber membranes synergistically accelerates CO2 removal from blood. Acta Biomaterialia, 25, 143-149.Elsevier BV. doi: 10.1doi:10.1016/j.actbio.2015.07.007016/j.actbio.2015.07.007.

Cook, K.E., Maul, T.M., & Federspiel, W.J. (2015). Artificial Lungs. In The Biomedical Engineering Handbook: Molecular, Cellular, and Tissue Engineering, Bronzino, J.D., & Peterson, D.R. (Eds.). (p. 78-1).CRC Press.

Cove, M.E., & Federspiel, W.J. (2015). Veno-venous extracorporeal CO2 removal for the treatment of severe respiratory acidosis. Crit Care, 19(1), 176.Springer Science and Business Media LLC. doi: 10.1186/s13054-015-0769-0.

Madhani, S., & Federspiel, W.J. (2015). Letter to the Editor on: "Darcy permeability of hollow fiber bundles used in blood oxygenation devices" [J. Membr. Sci. 382 (2011) 238-242]. JOURNAL OF MEMBRANE SCIENCE, 496, 359-360.Elsevier BV. doi: 10.1016/j.memsci.2015.09.012.

Malkin, A.D., Sheehan, R.P., Mathew, S., Federspiel, W.J., Redl, H., & Clermont, G. (2015). A Neutrophil Phenotype Model for Extracorporeal Treatment of Sepsis. In Tan, K. (Ed.). PLOS COMPUTATIONAL BIOLOGY, 11(10), e1004314.Public Library of Science (PLoS). doi: 10.1371/journal.pcbi.1004314.

Ye, S.H., Arazawa, D.T., Zhu, Y., Shankarraman, V., Malkin, A.D., Kimmel, J.D., Gamble, L.J., Ishihara, K., Federspiel, W.J., & Wagner, W.R. (2015). Hollow Fiber Membrane Modification with Functional Zwitterionic Macromolecules for Improved Thromboresistance in Artificial Lungs. LANGMUIR, 31(8), 2463-2471.American Chemical Society (ACS). doi: 10.1021/la504907m.

Zhang, J., Peng, Z., Maberry, D., Volpe, J., Kimmel, J.D., Federspiel, W.J., & Kellum, J.A. (2015). Effects of Hemoadsorption with a Novel Adsorbent on Sepsis: In vivo and in vitro Study. BLOOD PURIFICATION, 39(1-3), 239-245.S. Karger AG. doi: 10.1159/000381006.

Jeffries, R.G., Frankowski, B.J., Burgreen, G.W., & Federspiel, W.J. (2014). Effect of Impeller Design and Spacing on Gas Exchange in a Percutaneous Respiratory Assist Catheter. ARTIFICIAL ORGANS, 38(12), 1007-1017.Wiley. doi: 10.1111/aor.12308.

Jeffries, R.G., Mussin, Y., Bulanin, D.S., Lund, L.W., Kocyildirim, E., Zhumadilov, Z.Z., Olzhayev, F.S., Federspiel, W.J., & Wearden, P.D. (2014). Pre-clinical evaluation of an adult extracorporeal carbon dioxide removal system with active mixing for pediatric respiratory support. INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 37(12), 888-899.SAGE Publications. doi: 10.5301/ijao.5000372.

Mussin, Y., Jeffries, R., Bulanin, D., Zhumadilov, Z., Olzhayev, F., & Federspiel, W. (2014). Pre-clinical Evaluation of an Adult Extracoproreal Carbon Dioxide Removal System for Pediatric Application. Cent Asian J Glob Health, 3(Suppl), 167.University Library System, University of Pittsburgh. doi: 10.5195/cajgh.2014.167.

Peng, Z.Y., Bishop, J.V., Wen, X.Y., Elder, M.M., Zhou, F., Chuasuwan, A., Carter, M.J., Devlin, J.E., Kaynar, A.M., Singbart, K., Pike, F., Parker, R.S., Clermont, G., Federspiel, W.J., & Kellum, J.A. (2014). Modulation of chemokine gradients by apheresis redirects leukocyte trafficking to different compartments during sepsis, studies in a rat model. CRITICAL CARE, 18(4), R141.Springer Science and Business Media LLC. doi: 10.1186/cc13969.

Sen, A., Kellum, J., & Federspiel, W. (2014). EXTRACORPOREAL CARBON-DIOXIDE REMOVAL IS FEASIBLE USING A ZERO BICARBONATE DIALYSATE. CRITICAL CARE MEDICINE, 42, (p. A1521).Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/01.ccm.0000458168.22241.90.

Kimmel, J.D., Arazawa, D.T., Ye, S.H., Shankarraman, V., Wagner, W.R., & Federspiel, W.J. (2013). Carbonic anhydrase immobilized on hollow fiber membranes using glutaraldehyde activated chitosan for artificial lung applications. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 24(11), 2611-2621.Springer Science and Business Media LLC. doi: 10.1007/s10856-013-5006-2.

Lund, L.W., & Federspiel, W.J. (2013). Removing extra CO2 in COPD patients. Curr Respir Care Rep, 2(3), 131-138.Springer Science and Business Media LLC. doi: 10.1007/s13665-013-0057-x.

Rimmele, T., Kaynar, A.M., McLaughlin, J.N., Bishop, J.V., Fedorchak, M.V., Chuasuwan, A., Peng, Z., Singbartl, K., Frederick, D.R., Zhu, L., Carter, M., Federspiel, W.J., Zeevi, A., & Kellum, J.A. (2013). Leukocyte capture and modulation of cell-mediated immunity during human sepsis: an ex vivo study. CRITICAL CARE, 17(2), R59.Springer Science and Business Media LLC. doi: 10.1186/cc12587.

Sen, A., Kellum, J.A., & Federspiel, W.J. (2013). Extracorporeal Carbondioxide Removal By Zero Bicarbonate Dialysate: A Novel Lung Protection Strategy. Critical Care Medicine, 41, (p. A47).Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/01.ccm.0000439357.52072.a2.

Alikhani, A., & Federspiel, W.J. (2012). Selective capture of anti-A antibodies from human blood using a novel integrated bead and hollow fiber module. J Biomed Mater Res B Appl Biomater, 100(8), 2114-2121.Wiley. doi: 10.1002/jbm.b.32776.

Alikhani, A., & Federspiel, W.J. (2012). Selective capture of anti-A antibodies from human blood using a novel integrated bead and hollow fiber module. Journal of biomedical materials research. Part B, Applied biomaterials, 100(8), 2114-2121. doi: 10.1002/jbm.b.32776.

Arazawa, D.T., Oh, H.I., Ye, S.H., Jr, J.C.A., Woolley, J.R., Wagner, W.R., & Federspiel, W.J. (2012). Immobilized carbonic anhydrase on hollow fiber membranes accelerates CO2 removal from blood. JOURNAL OF MEMBRANE SCIENCE, 403, 25-31.Elsevier BV. doi: 10.1016/j.memsci.2012.02.006.

Cove, M., Sen, A., Federspiel, W., & Kellum, J. (2012). "RESPIRATORY DIALYSIS": A NOVEL APPROACH FOR ENABLING LUNG PROTECTIVE VENTILATION. CRITICAL CARE MEDICINE, 40, (p. U277).

Cove, M.E., MacLaren, G., Federspiel, W.J., & Kellum, J.A. (2012). Bench to bedside review: Extracorporeal carbon dioxide removal, past present and future. CRITICAL CARE, 16(5), 232.Springer Science and Business Media LLC. doi: 10.1186/cc11356.

Federspiel, W.J., & Valenti, I. (2012). On Laminar Flow in Microfabricated Channels with Partial Semi-Circular Profiles. Open Journal of Applied Sciences, 02(01), 28-34.Scientific Research Publishing, Inc. doi: 10.4236/ojapps.2012.21003.

Fisher, J.D., DiLeo, M.V., & Federspiel, W.J. (2012). Investigating Cytokine Binding Using a Previously Reported TNF-Specific Aptamer. Open Journal of Applied Sciences, 02(03), 135-138.Scientific Research Publishing, Inc. doi: 10.4236/ojapps.2012.23019.

Namas, R.A., Namas, R., Lagoa, C., Barclay, D., Mi, Q., Zamora, R., Peng, Z., Wen, X., Fedorchak, M.V., Valenti, I.E., Federspiel, W.J., Kellum, J.A., & Vodovotz, Y. (2012). Hemoadsorption Reprograms Inflammation in Experimental Gram-negative Septic Peritonitis: Insights from In Vivo and In Silico Studies. MOLECULAR MEDICINE, 18(10), 1366-1374.Springer Science and Business Media LLC. doi: 10.2119/molmed.2012.00106.

Peng, Z.Y., Wang, H.Z., Carter, M.J., Dileo, M.V., Bishop, J.V., Zhou, F.H., Wen, X.Y., Rimmele, T., Singbartl, K., Federspiel, W.J., Clermont, G., & Kellum, J.A. (2012). Acute removal of common sepsis mediators does not explain the effects of extracorporeal blood purification in experimental sepsis. KIDNEY INTERNATIONAL, 81(4), 363-369.Elsevier BV. doi: 10.1038/ki.2011.320.

Wearden, P.D., Federspiel, W.J., Morley, S.W., Rosenberg, M., Bieniek, P.D., Lund, L.W., & Ochs, B.D. (2012). Respiratory dialysis with an active-mixing extracorporeal carbon dioxide removal system in a chronic sheep study. Intensive Care Med, 38(10), 1705-1711.Springer Science and Business Media LLC. doi: 10.1007/s00134-012-2651-8.

Alikhani, A., & Federspiel, W.J. (2011). Theoretical and Experimental Analysis of Anti-A Antibody Capture in Novel Integrated Bead and Hollow Fiber Modules. ANNALS OF BIOMEDICAL ENGINEERING, 39(3), 953-963.Springer Science and Business Media LLC. doi: 10.1007/s10439-010-0233-x.

Batchinsky, A.I., Jordan, B.S., Regn, D., Necsoiu, C., Federspiel, W.J., Morris, M.J., & Cancio, L.C. (2011). Respiratory dialysis: Reduction in dependence on mechanical ventilation by venovenous extracorporeal CO2 removal. CRITICAL CARE MEDICINE, 39(6), 1382-1387.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/CCM.0b013e31820eda45.

DiLeo, M.V., Fisher, J.D., Burton, B.M., & Federspiel, W.J. (2011). Selective improvement of tumor necrosis factor capture in a cytokine hemoadsorption device using immobilized anti-tumor necrosis factor. J Biomed Mater Res B Appl Biomater, 96(1), 127-133.Wiley. doi: 10.1002/jbm.b.31748.

Kimmel, J.D., Harbert, E.M., Parker, R.S., & Federspiel, W.J. (2011). Modeling competitive cytokine adsorption dynamics within hemoadsorption beads used to treat sepsis. JOURNAL OF CHROMATOGRAPHY A, 1218(44), 8013-8020.Elsevier BV. doi: 10.1016/j.chroma.2011.09.007.

Kimmel, J.D., Lacko, C.S., Delude, R.L., & Federspiel, W.J. (2011). Characterizing accelerated capture of deoligomerized TNF within hemoadsorption beads used to treat sepsis. J Biomed Mater Res B Appl Biomater, 98(1), 47-53.Wiley. doi: 10.1002/jbm.b.31830.

Kimmel, J.D., Lacko, C.S., Delude, R.L., & Federspiel, W.J. (2011). ACCELERATED REMOVAL OF TNF WITHIN A HEMOADSORPTION DEVICE USED TO TREAT SEPSIS. INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 34, (p. 640).

Pacella, H.E., Eash, H.J., Frankowski, B.J., & Federspiel, W.J. (2011). Darcy permeability of hollow fiber bundles used in blood oxygenation devices. JOURNAL OF MEMBRANE SCIENCE, 382(1-2), 238-242.Elsevier BV. doi: 10.1016/j.memsci.2011.08.012.

Burki, N.K., Bieniek, P.D., Federspiel, W., Morley, S.W., Ochs, B.D., & Wearden, P.D. (2010). Efficacy of Extracorporeal CO2 Removal with the Hemolung: Results in Animals. Am J Respir Crit Care Med, 181.

DiLeo, M.V., & Federspiel, W.J. (2010). Scaling Issues in the Article Entitled "Cytokines in Blood From Septic Patients Interact With Surface-Immobilized Heparin". ASAIO JOURNAL, 56(4), 383-384.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/MAT.0b013e3181e4bfc3.

Gautam, S., Korchagina, E.Y., Bovin, N.V., & Federspiel, W.J. (2010). Specific antibody filter (SAF) binding capacity enhancement to remove anti-A antibodies. J Biomed Mater Res B Appl Biomater, 95(2), 475-480.Wiley. doi: 10.1002/jbm.b.31707.

Kimmel, J.D., Gibson, G.A., Watkins, S.C., Kellum, J.A., & Federspiel, W.J. (2010). IL-6 adsorption dynamics in hemoadsorption beads studied using confocal laser scanning microscopy. J Biomed Mater Res B Appl Biomater, 92(2), 390-396.Wiley. doi: 10.1002/jbm.b.31527.

Kimmel, J.D., Lacko, C.S., Delude, R.L., & Federspiel, W.J. (2010). Dynamics of TNF capture within hemoadsorption beads used to treat sepsis. ASME 2010 Summer Bioengineering Conference, SBC 2010, (pp. 85-86).American Society of Mechanical Engineers.Lake Tahoe, CA. doi: 10.1115/SBC2010-19242.

Oh, H.I., Ye, S.H., Jr, J.C.A., Woolley, J.R., Federspiel, W.J., & Wagner, W.R. (2010). Hemocompatibility Assessment of Carbonic Anhydrase Modified Hollow Fiber Membranes for Artificial Lungs. ARTIFICIAL ORGANS, 34(5), 439-442.Wiley. doi: 10.1111/j.1525-1594.2009.00882.x.

Polk, A.A., Maul, T.M., McKeel, D.T., Snyder, T.A., Lehocky, C.A., Pitt, B., Stolz, D.B., Federspiel, W.J., & Wagner, W.R. (2010). A Biohybrid Artificial Lung Prototype With Active Mixing of Endothelialized Microporous Hollow Fibers. BIOTECHNOLOGY AND BIOENGINEERING, 106(3), 490-500.Wiley. doi: 10.1002/bit.22675.

Alikhani, A., Korchagina, E.Y., Chinarev, A.A., Bovin, N.V., & Federspiel, W.J. (2009). High molecular weight blood group A trisaccharide-polyacrylamide glycoconjugates as synthetic blood group A antigens for anti-A antibody removal devices. J Biomed Mater Res B Appl Biomater, 91(2), 845-854.Wiley. doi: 10.1002/jbm.b.31466.

Budilarto, S.G., Frankowski, B.J., Hattler, B.G., & Federspiel, W.J. (2009). Flow Visualization Study of a Novel Respiratory Assist Catheter. ARTIFICIAL ORGANS, 33(6), 411-418.Wiley. doi: 10.1111/j.1525-1594.2009.00751.x.

Burgess, K.A., Hu, H.H., Wagner, W.R., & Federspiel, W.J. (2009). Towards microfabricated biohybrid artificial lung modules for chronic respiratory support. BIOMEDICAL MICRODEVICES, 11(1), 117-127.Springer Science and Business Media LLC. doi: 10.1007/s10544-008-9215-2.

Burgess, K.A., Wagner, W.R., & Federspiel, W.J. (2009). TOWARDS BIOHYBRID MICROFABRICATED ARTIFICIAL LUNGS. INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 32, (p. 402).Compiegne, France.

DiLeo, M.V., Fisher, J.D., & Federspiel, W.J. (2009). Experimental Validation of a Theoretical Model of Cytokine Capture Using a Hemoadsorption Device. ANNALS OF BIOMEDICAL ENGINEERING, 37(11), 2310-2316.Springer Science and Business Media LLC. doi: 10.1007/s10439-009-9780-4.

DiLeo, M.V., Kellum, J.A., & Federspiel, W.J. (2009). A Simple Mathematical Model of Cytokine Capture Using a Hemoadsorption Device. ANNALS OF BIOMEDICAL ENGINEERING, 37(1), 222-229.Springer Science and Business Media LLC. doi: 10.1007/s10439-008-9587-8.

DiLeo, M.V., Kimmel, J.D., Kellum, J.A., & Federspiel, W.J. (2009). MODELING CYTOKINE CAPTURE IN A HEMOADSORPTION DEVICE FOR THE TREATMENT OF SEPSIS. INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 32, (p. 419).Compiegne, France.

Kimmel, J.D., DiLeo, M.V., Valenti, I.E., Gibson, G.A., Watkins, S.C., & Federspiel, W.J. (2009). Dynamics of cytokine capture within hemoadsorption beads used to treat sepsis. Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009, (pp. 947-948).American Society of Mechanical Engineers.Pittsburgh, PA. doi: 10.1115/SBC2009-204764.

Mihelc, K.M., Frankowski, B.J., Lieber, S.C., Moore, N.D., Hattler, B.G., & Federspiel, W.J. (2009). Evaluation of a Respiratory Assist Catheter that Uses an Impeller Within a Hollow Fiber Membrane Bundle. ASAIO JOURNAL, 55(6), 569-574.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/MAT.0b013e3181bc2655.

Rothstein, S.N., Federspiel, W.J., & Little, S.R. (2009). A unified mathematical model for the prediction of controlled release from surface and bulk eroding polymer matrices. Biomaterials, 30(8), 1657-1664.Elsevier BV. doi: 10.1016/j.biomaterials.2008.12.002.

Gautam, S., Korchagina, E.Y., Bovin, N.V., & Federspiel, W.J. (2008). Monoclonal anti-A antibody removal by synthetic a antigen immobilized on specific antibody filters. BIOTECHNOLOGY AND BIOENGINEERING, 99(4), 876-883.Wiley. doi: 10.1002/bit.21621.

Jr, E.G.C., Soletti, L., Vigmostad, S.C., Budilarto, S.G., Federspiel, W.J., Chandran, K.B., Vorp, D.A., & Sacks, M.S. (2008). A novel flex-stretch-flow bioreactor for the study of engineered heart valve tissue mechanobiology. ANNALS OF BIOMEDICAL ENGINEERING, 36(5), 700-712.Springer Science and Business Media LLC. doi: 10.1007/s10439-008-9447-6.

Kimmel, J.D., & Federspiel, W. (2008). Cytokine Hemoadsorption Dynamics using Confocal Laser Scanning Microscopy. ASAIO Journal, 54, (p. 7A).

Morley, S., Rosenberg, M., Federspiel, W., Hattler, B.G., & Batchinsky, A. (2008). Respiratory Dialysis. A New Therapy for Chronic Obstructive Pulmonary Disease. Critical Care, 12, (p. P303).

Rothstein, S.N., Federspiel, W.J., & Little, S.R. (2008). A simple model framework for the prediction of controlled release from bulk eroding polymer matrices. JOURNAL OF MATERIALS CHEMISTRY, 18(16), 1873-1880.Royal Society of Chemistry (RSC). doi: 10.1039/b718277e.

Svitek, R.G., & Federspiel, W.J. (2008). A mathematical model to predict CO2 removal in hollow fiber membrane oxygenators. ANNALS OF BIOMEDICAL ENGINEERING, 36(6), 992-1003.Springer Science and Business Media LLC. doi: 10.1007/s10439-008-9482-3.

Eash, H.J., Mihelc, K.M., Frankowski, B.J., Hattler, B.G., & Federspiel, W.J. (2007). Evaluation of fiber bundle rotation for enhancing gas exchange in a respiratory assist catheter. ASAIO JOURNAL, 53(3), 368-373.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/MAT.0b013e318031af3b.

Federspiel, W. (2007). Basic transport phenomena in biomedical engineering: a review. ASAIO J, 53(3), e7.

Kaar, J.L., Oh, H.I., Russell, A.J., & Federspiel, W.J. (2007). Towards improved artificial lungs through biocatalysis. BIOMATERIALS, 28(20), 3131-3139.Elsevier BV. doi: 10.1016/j.biomaterials.2007.03.021.

Zinovik, I.N., & Federspiel, W.J. (2007). Modeling of blood flow in a balloon-pulsed intravascular respiratory catheter. ASAIO JOURNAL, 53(4), 464-468.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/MAT.0b013e31805fe96d.

Eash, H.J., Budilarto, S.G., Hattler, B.G., & Federspiel, W.J. (2006). Investigating the effects of random balloon pulsation on gas exchange in a respiratory assist catheter. ASAIO JOURNAL, 52(2), 192-195.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/01.mat.0000199752.89066.83.

Gautam, S., Alikhani, A., Bovin, N.V., & Federspiel, W. (2006). Antibody Removal by Immobilized Synthetic Antigen in Specific Antibody Filters. ASAIO Journal, 52, (p. 13A).

Oh, H.I., Kaar, J.L., Russell, A.J., & Federspiel, W. (2006). Immobilization and assessment of carbonic anhydrase on hollow fiber membranes for enzyme-enhanced artificial lungs. ASAIO Journal, 52, (p. 67A).

Polk, A.A., McKeel, D.T., Federspiel, W., & Wagner, W.R. (2006). A biohybrid lung prototype with active mixing and oxygenation of endothelialized microporous hollow fibers. ASAIO Journal, 52, (p. 67A).

Snyder, T.A., Eash, H.J., Litwak, K.N., Frankowski, B.J., Hattler, B.G., Federspiel, W.J., & Wagner, W.R. (2006). Blood biocompatibility assessment of an intravenous gas exchange device. ARTIFICIAL ORGANS, 30(9), 657-664.Wiley. doi: 10.1111/j.1525-1594.2006.00281.x.

Solovan, J.C., Oh, H.I., Alikhani, A., Gautam, S., Vlasova, K., Korchagina, E.Y., Bovin, N.V., & Federspiel, W.J. (2006). Synthetic blood group antigens for anti-A removal device and their interaction with monoclonal anti-A IgM. TRANSPLANT IMMUNOLOGY, 16(3-4), 245-249.Elsevier BV. doi: 10.1016/j.trim.2006.08.003.

Budilarto, S.G., Eash, H.J., Hattler, B.G., & Federspiel, W. (2005). Flow visualization study of a pulsating respiratory assist catheter. ASAIO Journal, 51, (p. 53A).

Budilarto, S.G., Frankowski, B.J., Hattler, B.G., & Federspiel, W.J. (2005). Flow visualization study of a pulsating respiratory assist catheter. ASAIO J, 51(6), 673-680.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/01.mat.0000187393.79866.9c.

Burgess, K.A., Yang, G., Wagner, W.R., & Federspiel, W. (2005). Development of Microfabricated Biohybrid Artificial Lungs. ASAIO Journal, 51, (p. 53A).

Eash, H.J., Budilarto, S.G., Hattler, B.G., & Federspiel, W. (2005). Can random balloon pulsation enhance gas exchange in a pulsating respiratory support catheter?. ASAIO Journal, 51, (p. 49A).

Eash, H.J., Frankowski, B.J., Hattler, B.G., & Federspiel, W.J. (2005). Evaluation of local gas exchange in a pulsating respiratory support catheter. ASAIO Journal, 51(2), 152-157.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/01.MAT.0000153648.11692.D0.

Hagglund, N.J., Frankowski, B.J., Hattler, B.G., & Federspiel, W. (2005). The potential use of rotational fiber bundles in respiratory assist catheters. ASAIO Journal, 51, (p. 53A).

Kanick, S.C., Doyle, W.J., Ghadiali, S.N., & Federspiel, W.J. (2005). On morphometric measurement of oxygen diffusing capacity in middle ear gas exchange. JOURNAL OF APPLIED PHYSIOLOGY, 98(1), 114-119.American Physiological Society. doi: 10.1152/japplphysiol.00203.2004.

Polk, A.A., McKeel, D.T., Federspiel, W., & Wagner, W.R. (2005). A biohybrid lung prototype with endothelialized microporous hollow fibers in a rotating module. ASAIO Journal, 51, (p. 55A).

Svitek, R.G., Frankowski, B.J., & Federspiel, W.J. (2005). Evaluation of a pumping assist lung that uses a rotating fiber bundle. ASAIO JOURNAL, 51(6), 773-780.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/01.mat.0000178970.00971.43.

Svitek, R.G., Frankowski, R.G., & Federspiel, W. (2005). The effect of bundle porosity on the performance of a pumping paracorporeal assist lung using a rotating fiber bundle. ASAIO Journal, 51, (p. 52A).

Eash, H.J., Frankowski, B.J., Hattler, B.G., & Federspiel, W. (2004). Evaluation of local gas exchange in an artificial lung catheter. ASAIO Journal, 50, (p. 153).

Eash, H.J., Jones, H.M., Hattler, B.G., & Federspiel, W.J. (2004). Evaluation of plasma resistant hollow fiber membranes for artificial lungs. ASAIO JOURNAL, 50(5), 491-497.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/01.MAT.0000138078.04558.FE.

Federspiel, W., & Henchir, K.A. (2004). Artificial lungs: basic principles and current applications. In Encyclopedia of Biomaterials and Biomedical Engineering, Wneck, G.E., & Bowlin, G.L. (Eds.). (pp. 910-921).Marcel Dekker, Inc.

Federspiel, W., & Svitek, R.G. (2004). Artificial lungs: current research and future directions. In Encyclopedia of Biomaterials and Biomedical Engineering, Wneck, G.E., & Bowlin, G.L. (Eds.). (pp. 922-931).Marcel Dekker, Inc.

Nolan, T.D.C., Hattler, B.G., & Federspiel, W.J. (2004). Development of a balloon volume sensor for pulsating balloon catheters. ASAIO J, 50(3), 225-233.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/01.mat.0000123635.20778.52.

Wu, Z.J., & Federspiel, W. (2004). DPIV flow study of a pulsating artificial lung catheter. ASAIO Journal, 50, (p. 173).

Zinovik, I.N., Svitek, R.G., & Federspiel, W. (2004). CFD analysis of hydrodynamic characteristics of a novel paracorporeal pumping artificial lung. ASAIO Journal, 50, (p. 157).

Eash, H.J., Frankowski, B.J., Litwak, K., Wagner, W.R., Hattler, B.G., & Federspiel, W.J. (2003). Acute in vivo testing of a respiratory assist catheter: Implants in calves versus sheep. ASAIO JOURNAL, 49(4), 370-377. doi: 10.1097/01.MAT.0000074991.94234.B6.

Hattler, B.G., & Federspiel, W. (2003). The artificial lung. In Lung Transplantation, Banner, N.R., Polak, J.M., & Yacoub, M. (Eds.). (pp. 386-398).Cambridge University Press.

Henchir, K.A., Wagner, W.R., & Federspiel, W. (2003). Microfabrication of biohybrid artificial alveolar - capillary modules. Int. J. Cardiovasc. Med. Sci., 6, (pp. 65-150).

Hout, M.S., & Federspiel, W.J. (2003). Mathematical and experimental analyses of antibody transport in hollow-fiber-based specific antibody filters. Biotechnol Prog, 19(5), 1553-1561.Wiley. doi: 10.1021/bp025796f.

Polk, A.A., Federspiel, W., & Wagner, W.R. (2003). Modified microporous hollow fibers to support endothelial cell adhesion. ASAIO Journal, 49, (p. 217).

Svitek, R.G., Frankowski, B.J., & Federspiel, W. (2003). Enhanced gas exchange in an emergency respiratory support lung. Int. J. Cardiovasc. Med. Sci., 6, (pp. 65-150).

Drevon, G.F., Danielmeier, K., Federspiel, W., Stolz, D.B., Wicks, D.A., Yu, P.C., & Russell, A.J. (2002). High-activity enzyme-polyurethane coatings. BIOTECHNOLOGY AND BIOENGINEERING, 79(7), 785-794.Wiley. doi: 10.1002/bit.10334.

Garcia, M.Y., Hattler, B.G., & Federspiel, W.J. (2002). Effect of vessel compliance on the in-vitro performance of a pulsating respiratory support catheter. JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 124(1), 56-62.ASME International. doi: 10.1115/1.1428556.

Ghadiali, S.N., Federspiel, W.J., Swarts, J.D., & Doyle, W.J. (2002). Measurement of the viscoelastic compliance of the eustachian tube using a modified forced-response test. AURIS NASUS LARYNX, 29(1), 1-5.Elsevier BV. doi: 10.1016/S0385-8146(01)00116-X.

Ghadiali, S.N., Swarts, J.D., & Federspiel, W.J. (2002). Model-based evaluation of eustachian tube mechanical properties using continuous pressure-flow rate data. ANNALS OF BIOMEDICAL ENGINEERING, 30(8), 1064-1076.Springer Science and Business Media LLC. doi: 10.1114/1.1509764.

Hattler, B.G., & Federspiel, W. (2002). Gas exchange in the venous system: support for the failing lung. In The Artificial Lung, Vaslef, S.N., & Anderson, R.W. (Eds.). (pp. 133-174).Landes Bioscience.

Hattler, B.G., Lund, L.W., Golob, J., Russian, H., Lann, M.F., Merrill, T.L., Frankowski, B., & Federspiel, W.J. (2002). A respiratory gas exchange catheter: In vitro and in vivo tests in large animals. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 124(3), 520-530.Elsevier BV. doi: 10.1067/mtc.2002.123811.

Hout, M.S., & Federspiel, W. (2002). Kinetics of extracorporeal antibody removal by hollow fiber-based selective antibody filters. ASAIO Journal, 48, (p. 196).

Lai, J., Gouldstone, A., Butler, J.P., Federspiel, W.J., & Loring, S.H. (2002). Relative motion of lung and chest wall promotes uniform pleural space thickness. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 131(3), 233-243.Elsevier BV. doi: 10.1016/S1569-9048(02)00091-5.

Lund, L.W., Hattler, B.G., & Federspiel, W.J. (2002). A comparative in vitro hemolysis study of a pulsating intravenous artificial lung. ASAIO JOURNAL, 48(6), 631-635.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/00002480-200211000-00009.

Lund, L.W., Hattler, B.G., & Federspiel, W.J. (2002). Gas permeance measurement of hollow fiber membranes in gas-liquid environment. AICHE JOURNAL, 48(3), 635-643.Wiley. doi: 10.1002/aic.690480320.

Nolan, T.D., Hattler, B.G., & Federspiel, W. (2002). Development of a dynamic balloon volume sensor. ASAIO Journal, 48, (p. 158).

Russian, H.J., Conover, S.P., Hattler, B.G., & Federspiel, W. (2002). Evaluation of plasma resistant coatings for hollow fiber membranes. ASAIO Journal, 48, (p. 155).

Snyder, T.A., Lund, L., Russian, H., Litwak, K.N., Hattler, B.G., Federspiel, W., & Wagner, W.R. (2002). Assessing and improving the biocompatibility of an intravascular oxygenator. Trans. Soc. Biomat., 28, (p. 37).

Snyder, T.A., Russian, H.J., Litwak, K.N., Federspiel, W., Hattler, B.G., & Wagner, W.R. (2002). Assessing thrombosis of an intravascular respiratory support catheter. ASAIO Journal, 48, (p. 154).

Garcia, M.Y., Federspiel, W., & Hattler, B.G. (2001). Effect of vessel compliance on the in-vitro performance of a pulsating respiratory support catheter. ASAIO Journal, 47, (p. 172).

Garcia, M.Y., Hattler, B.G., & Federspiel, W. (2001). Effect of vessel compliance on the in-vitro performance of a pulsating respiratory support catheter. Ann. Biomed. Eng., 29, (p. S5).

Ghadiali, S.N., Federspiel, W.J., Douglas Swarts, J., & Doyle, W.J. (2001). Measurement of Eustachian tube mechanical properties using a modified forced response test. American Society of Mechanical Engineers, Bioengineering Division (Publication) BED, 50, (pp. 443-444).Snowbird, UT.

Golob, J.F., Federspiel, W.J., Merrill, T.L., Frankowski, B.J., Litwak, K., Russian, H., & Hattler, B.G. (2001). Acute in vivo testing of an intravascular respiratory support catheter. ASAIO JOURNAL, 47(5), 432-437.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/00002480-200109000-00003.

Hout, M.S., & Federspiel, W. (2001). Design of hollow fiber immunoadsorption modules for therapeutic antibody removal. ASAIO Journal, 47, (p. 172).

Hout, M.S., & Federspiel, W. (2001). Kinetics of antibody capture by hollow fiber-based selective antibody filters. Ann. Biomed. Eng., 29, (p. S87).

Lund, L.W., Franklin-Ford, T., Russian, H.J., Hattler, B.G., & Federspiel, W. (2001). A comparative in-vitro hemolysis study of a pulsating intravenous artificial lung. ASAIO Journal, 47, (p. 115).

Snyder, T.A., Watach, M.K., Gordon, L.M., Litwak, K.N., Lund, L.W., Golob, J.F., Federspiel, W., Hattler, B.G., & Wagner, W.R. (2001). Evaluating biocompatibility in an intravenous membrane oxygenator. Trans. Soc. Biomat., 27, (p. 420).

Federspiel, W., & Hattler, B.G. (2000). Development of an intravenous respiratory support catheter. Ann. Biomed. Eng., 28, (pp. S-2).

Federspiel, W.J., Golob, J.F., Merrill, T.L., Lund, L.W., Bultman, J.A., Frankowski, B.J., Watach, M., Litwak, K., & Hattler, B.G. (2000). Ex vivo testing of the intravenous membrane oxygenator. ASAIO JOURNAL, 46(3), 261-267.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/00002480-200005000-00004.

Federspiel, W.J., Hewitt, T.J., & Hattler, B.G. (2000). Experimental evaluation of a model for oxygen exchange in a pulsating intravascular artificial lung. ANNALS OF BIOMEDICAL ENGINEERING, 28(2), 160-167.Springer Science and Business Media LLC. doi: 10.1114/1.240.

Golob, J.F., Federspiel, W.J., Merrill, T.L., Frankowski, B.J., Russian, H.J., Litwak, K., & Hattler, B.G. (2000). ACUTE IN-VIVO TESTING OF THE INTRAVENOUS MEMBRANE OXYGENATOR (IMO). ASAIO Journal, 46, (p. 180).Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/00002480-200003000-00119.

Hout, M.S., & Federspiel, W.J. (2000). Kinetics of antibody removal by dialysis membrane immunoadsorption. ASAIO Journal, 46, (p. 230).Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/00002480-200003000-00318.

Hout, M.S., Hattler, B.G., & Federspiel, W.J. (2000). Validation of a model for flow-dependent carbon dioxide exchange in artificial lungs. ARTIFICIAL ORGANS, 24(2), 114-118.Wiley. doi: 10.1046/j.1525-1594.2000.06465.x.

Hout, M.S., LeJeune, K.E., Schaack, T.M., Bristow, D.K., & Federspiel, W.J. (2000). Specific removal of anti-A and anti-B antibodies by using modified dialysis filters. ASAIO JOURNAL, 46(6), 702-706.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/00002480-200011000-00010.

Merrill, T.L., Hattler, B.G., & Federspiel, W.J. (2000). DETERMINING OXYGEN EXCHANGE FROM GAS-SIDE ANALYSIS IN ARTIFICIAL LUNGS. ASAIO Journal, 46, (p. 180).Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/00002480-200003000-00118.

Tulou, T., Hattler, B.G., & Federspiel, W. (2000). Development of a balloon drive system for the intravascular membrane oxygenator. ASAIO Journal, 46, (p. 230).Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/00002480-200003000-00317.

Federspiel, W., Lund, L.W., Bultman, J.A., Wanant, S., Matoney, J., Golob, J.F., Frankowski, B.J., Watach, M., Litwak, P., & Hattler, B.G. (1999). Ex-vivo testing of the intravenous membrane oxygenator (IMO). ASAIO Journal, 45, (p. 127).

Federspiel, W.J., Golob, J.F., Frankowski, B.J., Merrill, T.L., Litwak, K., & Hattler, B.G. (1999). Development and testing of an intravascular artificial lung. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 1, (p. 345).

Golob, J.F., Federspiel, W., Merrill, T.L., Frankowski, B.J., & Hattler, B.G. (1999). Analysis of in-vivo flow effects on the in-vitro testing of intravascular oxygenators. ASAIO Journal, 45, (p. 126).

Hattler, B.G., & Federspiel, W.J. (1999). Progress with the development of the intravenous membrane oxygenator. PERFUSION-UK, 14(4), 311-315.SAGE Publications. doi: 10.1177/026765919901400411.

Hout, M.S., LeJeune, K.E., Schaack, T.M., Bristow, D.K., & Federspiel, W.J. (1999). Specific removal of anti-A and anti-B antibodies using modified dialysis filters. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 2, (p. 740).Atlanta, GA.

Hout, M.S., LeJeune, K.E., Schaak, T., Bristow, D., & Federspiel, W. (1999). Specific removal of anti-A and anti-B antibodies using modified dialysis and plasmapheresis filters. ASAIO Journal, 45, (p. 193).

Lund, L.W., & Federspiel, W.J. (1999). Augmentation of oxygen flux from hollow fiber membranes in blood. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 2, (p. 771).Atlanta, GA.

Guzman, A.M., Amon, C.H., Federspiel, W., & Hattler, B.G. (1998). Spectral-element simulations of the flow kinematics in an intravenous membrane oxygenator. In Computational Mechanics, CIMNE, Dvorkin, E., Idelsohn, S., & Onate, E. (Eds.). Barcelona.

Hewitt, T.J., Hattler, B.G., & Federspiel, W.J. (1998). A mathematical model of gas exchange in an intravenous membrane oxygenator. ANNALS OF BIOMEDICAL ENGINEERING, 26(1), 166-178.Springer Science and Business Media LLC. doi: 10.1114/1.53.

Hout, M.S., Hattler, B.G., & Federspiel, W. (1998). A simple model of flow-dependent CO2 exchange in artificial lungs. ASAIO Journal, 44, (p. 7).

Lund, L.W., Hattler, B.G., & Federspiel, W. (1998). Analysis of condensation as a cause of plasma leakage in microporous membrane oxygenators. ASAIO Journal, 44, (p. 23).

Lund, L.W., Hattler, B.G., & Federspiel, W.J. (1998). Is condensation the cause of plasma leakage in microporous hollow fiber membrane oxygenators. JOURNAL OF MEMBRANE SCIENCE, 147(1), 87-93.Elsevier BV. doi: 10.1016/S0376-7388(98)00121-5.

Vorp, D.A., Wang, D.H.J., Webster, M.W., & Federspiel, W.J. (1998). Effect of intraluminal thrombus thickness and bulge diameter on the oxygen diffusion in abdominal aortic aneurysm. JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 120(5), 579-583.ASME International. doi: 10.1115/1.2834747.

Federspiel, W., Hout, M.S., Hewitt, T.J., Lund, L.W., Heinrich, S.A., Macha, M., Litwak, P., Walters, F.R., Borovetz, H.S., & Hattler, B.G. (1997). Development of a low flow resistance intravenous oxygenator. ASAIO Journal, 43, (p. 14).

Federspiel, W.J., Hout, M.S., Hewitt, T.J., Lund, L.W., Heinrich, S.A., Litwak, P., Walters, F.R., Reeder, G.D., Borovetz, H.S., & Hattler, B.G. (1997). Development of a low flow resistance intravenous oxygenator. ASAIO JOURNAL, 43(5), M725-M730.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/00002480-199709000-00079.

Kameneva, M.V., Borovetz, H.S., Antaki, J.F., Litwak, P., Federspiel, W.J., Kormos, R.L., & Griffith, B.P. (1997). Effect of perfluorochemical emulsion on hemorheology and shear induced blood trauma - Possible mechanisms and future applications. OXYGEN TRANSPORT TO TISSUE XVIII, 411, 383-390.Springer US. doi: 10.1007/978-1-4615-5865-1_49.

Vorp, D.A., Wang, D.H.J., Webster, M.W., & Federspiel, W.J. (1997). Computational analysis of the oxygen flow in abdominal aortic aneurysm: Effect of intraluminal thrombus thickness and aneurysm diameter. American Society of Mechanical Engineers, Bioengineering Division (Publication) BED, 35, 73-74.

Federspiel, W., Swazik, P., Borovetz, H., Reeder, G.D., & Hattler, B.G. (1996). Temporary support of the lungs - the artificial lung. In The Transplantation and Replacement of Thoracic Organs, Cooper, D.K., Miller, L.W., & Patterson, G.A. (Eds.). Kluwer Academic Publishers.

Federspiel, W., Walters, F., Hewitt, T., Hout, M., Lund, L., Sawzik, P., Reeder, G., Borovetz, H., & Hattler, B.G. (1996). Recent progress in engineering the Pittsburgh intravenous membrane oxygenator. ASAIO Journal, 42, (p. 71).

Federspiel, W., Walters, F.R., Hewitt, T., Hout, M.S., Lund, L., & Hattler, B.G. (1996). Further development of an intravenous membrane oxygenator with active mixing. Ann. Biomed. Eng., 24, (p. S6).

Federspiel, W.J., & Hattler, B.G. (1996). Sweep gas flowrate and CO2 exchange in artificial lungs. ARTIFICIAL ORGANS, 20(9), 1050-1052.Wiley. doi: 10.1111/j.1525-1594.1996.tb04593.x.

Federspiel, W.J., Hewitt, T., Hout, M.S., Walters, F.R., Lund, L.W., Sawzik, P.J., Reeder, G., Borovetz, H.S., & Hattler, B.G. (1996). Recent progress in engineering the Pittsburgh intravenous membrane oxygenator. ASAIO JOURNAL, 42(5), M435-M442.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/00002480-199609000-00026.

Federspiel, W.J., Williams, J.L., & Hattler, B.G. (1996). Gas flow dynamics in hollow-fiber membranes. AICHE JOURNAL, 42(7), 2094-2099.Wiley. doi: 10.1002/aic.690420732.

Hout, M.S., Hattler, B.G., & Federspiel, W. (1996). A simple model of flow dependent CO2 exchange in artificial lungs. Ann. Biomed. Eng., 24, (p. S8).

Konishi, R., Firestone, W., Wagner, W., Federspiel, W., Konishi, H., Shimizu, R., & Hattler, B.G. (1996). Nitric oxide presents human platelet adhesion on fiber membrane in whole blood. ASAIO Journal, 42, (p. 72).

Konishi, R., Shimizu, R., Firestone, L., Walters, F.R., Wagner, W.R., Federspiel, W.J., Konishi, H., & Hattler, B.G. (1996). Nitric oxide prevents human platelet adhesion to fiber membranes in whole blood. ASAIO JOURNAL, 42(5), M850-M853.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/00002480-199609000-00111.

Lund, L., Federspiel, W., Taitel, F., & Hattler, B.G. (1996). A novel method for measuring hollow fiber membrane permeability in a gas-liquid system. ASAIO Journal, 42, (p. 67).

Lund, L.W., Federspiel, W., & Hattler, B.G. (1996). Hollow fiber membrane permeability evaluation for use in intracorporeal artificial lungs. Ann. Biomed. Eng., 24, (p. S8).

Lund, L.W., Federspiel, W.J., & Hattler, B.G. (1996). Gas permeability of hollow fiber membranes in a gas-liquid system. JOURNAL OF MEMBRANE SCIENCE, 117(1-2), 207-219.Elsevier BV. doi: 10.1016/0376-7388(96)00064-6.

Lund, L.W., Federspiel, W.J., Walters, F.R., & Hattler, B.G. (1996). A novel method for measuring hollow fiber membrane permeability in a gas-liquid system. ASAIO JOURNAL, 42(5), M446-M451.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/00002480-199609000-00028.

Macha, M., Federspiel, W., Lund, L., Sawzik, P., Litwak, P., Borovetz, H., Walters, F., Reeder, G., & Hattler, B.G. (1996). Acute in-vivo studies of the Pittsburgh intravenous membrane oxygenator. ASAIO Journal, 42, (p. 69).

Macha, M., Federspiel, W.J., Lund, L.W., Sawzik, P.J., Litwak, P., Walters, F.R., Reeder, G.D., Borovetz, H.S., & Hattler, B.G. (1996). Acute in vivo studies of the Pittsburgh Intravenous Membrane Oxygenator. ASAIO JOURNAL, 42(5), M609-M615.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/00002480-199609000-00060.

Vorp, D.A., Federspiel, W.J., & Webster, M.W. (1996). Does laminated intraluminal thrombus within abdominal aortic aneurysm cause anoxia of the aortic wall. JOURNAL OF VASCULAR SURGERY, 23(3), 540-541.Elsevier BV. doi: 10.1016/S0741-5214(96)80027-9.

CHAMMAS, P., FEDERSPIEL, W.J., & EISENBERG, S.R. (1994). A MICROCONTINUUM MODEL OF ELECTROKINETIC COUPLING IN THE EXTRACELLULAR-MATRIX - PERTURBATION FORMULATION AND SOLUTION. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 168(2), 526-538.Elsevier BV. doi: 10.1006/jcis.1994.1451.

FEDERSPIEL, W.J., & MALAI, K. (1993). MODEL EXPERIMENTS ON MEASURING FLOW IN MICROVESSELS USING TRACERS. MICROVASCULAR RESEARCH, 46(3), 333-350.Elsevier BV. doi: 10.1006/mvre.1993.1057.

WEIBEL, E.R., FEDERSPIEL, W.J., FRYDERDOFFEY, F., HSIA, C.C.W., KONIG, M., STALDERNAVARRO, V., & VOCK, R. (1993). MORPHOMETRIC MODEL FOR PULMONARY DIFFUSING-CAPACITY .1. MEMBRANE DIFFUSING-CAPACITY. RESPIRATION PHYSIOLOGY, 93(2), 125-149.Elsevier BV. doi: 10.1016/0034-5687(93)90001-Q.

BUNK, D.A., FEDERSPIEL, W.J., & JACKSON, A.C. (1992). INFLUENCE OF BIFURCATIONS ON FORCED-OSCILLATIONS IN AN AIRWAY MODEL. JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 114(2), 216-221.ASME International. doi: 10.1115/1.2891374.

FEDERSPIEL, W.J. (1992). ANALYSIS OF EFFECTIVE AXIAL DIFFUSION IN BRANCHING NETWORKS. AICHE JOURNAL, 38(10), 1631-1638.Wiley. doi: 10.1002/aic.690381013.

Lai, J., Federspiel, W., Butler, J.P., & Loring, S.H. (1992). A computational study of pleural pressure induced by lung motion. FASEB Journal, 6, (p. A1480).

Malai, K.P., & Federspiel, W. (1992). Use of tracers to measure flow in branching microvessels. FASEB Journal, 6, (p. A2079).

Federspiel, W. (1991). On the trumpet model of acinar gas transport. In Advances in Biological Heat and Mass Transfer, McGrath, J.J. (Ed.). 18, (pp. 39-42).ASME Bioengineering Division.

TSUDA, A., FEDERSPIEL, W.J., GRANT, P.A., & FREDBERG, J.J. (1991). AXIAL-DISPERSION OF INERT SPECIES IN ALVEOLATED CHANNELS. CHEMICAL ENGINEERING SCIENCE, 46(5-6), 1419-1426.Elsevier BV. doi: 10.1016/0009-2509(91)85068-9.

Federspiel, W. (1990). Use of tracers to measure plasma flow within individual microvessels. FASEB Journal, 4, (p. A1251).

Federspiel, W. (1990). Nonclassical features of gas transport and exchange at the alveolar level. In Respiratory Biomechanics: Engineering Analysis of Structure and Function, Farrell-Epstein, M.A., & Ligas, J.R. (Eds.). (pp. 90-97).Springer Verlag.

Federspiel, W. (1990). Fluid mechanics in alveolar ducts. In Biofluid Mechanics 3, Schneck, D.J., & Lucas, C.L. (Eds.). (pp. 21-25).New York University Press.

FEDERSPIEL, W.J. (1990). USE OF TRACERS TO MEASURE FLOW WITHIN SINGLE MICROVESSELS. MICROVASCULAR RESEARCH, 40(3), 394-411.Elsevier BV. doi: 10.1016/0026-2862(90)90035-P.

FEDERSPIEL, W.J. (1989). PULMONARY DIFFUSING-CAPACITY - IMPLICATIONS OF 2-PHASE BLOOD-FLOW IN CAPILLARIES. RESPIRATION PHYSIOLOGY, 77(1), 119-134.Elsevier BV. doi: 10.1016/0034-5687(89)90035-2.

Tsuda, A., Federspiel, W., Grant Jr, P.A., & Fredberg, J.J. (1989). Axial dispersion of inert species in alveolated ducts. Fed. Proc., 3, (p. A686).

Federspiel, W. (1988). Influence of the particulate nature of blood on pulmonary oxygen exchange. The Physiologist, 31, (p. A170).

FEDERSPIEL, W.J., & FREDBERG, J.J. (1988). AXIAL-DISPERSION IN RESPIRATORY BRONCHIOLES AND ALVEOLAR DUCTS. JOURNAL OF APPLIED PHYSIOLOGY, 64(6), 2614-2621.American Physiological Society. doi: 10.1152/jappl.1988.64.6.2614.

Gayeski, T.E., Federspiel, W.J., & Honig, C.R. (1988). A graphical analysis of the influence of red cell transit time, carrier-free layer thickness, and intracellular PO2 on blood-tissue O2 transport. Adv Exp Med Biol, 222, 25-35.Springer US. doi: 10.1007/978-1-4615-9510-6_3.

Federspiel, W., & Fredberg, J.J. (1987). Gas transport in respiratory bronchioles and alveolar ducts. Fed. Proc., 46, (p. 1427).

Federspiel, W., & Fredberg, J.J. (1986). Influence of structural complexity on axial dispersion in the acinus. The Physiologist, 29, (p. 94).

FEDERSPIEL, W.J. (1986). A MODEL STUDY OF INTRACELLULAR OXYGEN GRADIENTS IN A MYOGLOBIN-CONTAINING SKELETAL-MUSCLE FIBER. BIOPHYSICAL JOURNAL, 49(4), 857-868.Elsevier BV. doi: 10.1016/S0006-3495(86)83715-8.

FEDERSPIEL, W.J., & POPEL, A.S. (1986). A THEORETICAL-ANALYSIS OF THE EFFECT OF THE PARTICULATE NATURE OF BLOOD ON OXYGEN RELEASE IN CAPILLARIES. MICROVASCULAR RESEARCH, 32(2), 164-189.Elsevier BV. doi: 10.1016/0026-2862(86)90052-X.

Clark, A., Federspiel, W.J., Clark, P.A., & Cokelet, G.R. (1985). Oxygen delivery from red cells. Biophys J, 47(2 Pt 1), 171-181.Elsevier BV. doi: 10.1016/s0006-3495(85)83890-x.

CLARK, A., FEDERSPIEL, W.J., CLARK, P.A.A., & COKELET, G.R. (1985). OXYGEN DELIVERY FROM RED-CELLS. BIOPHYSICAL JOURNAL, 47(2), 171-181. doi: 10.1016/S0006-3495(85)83890-X.

Federspiel, W., & Popel, A.S. (1984). A theoretical analysis of the effect of the particulate nature of blood on oxygen release in capillaries. Int. J. Microcirc., 3, (p. 407).

FEDERSPIEL, W.J. (1984). THE EFFECT OF MYOGLOBIN CONCENTRATION ON MUSCLE-CELL PO2 GRADIENTS. ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, 180, 539-543.Springer US. doi: 10.1007/978-1-4684-4895-5_51.

Federspiel, W.J., & Cokelet, G.R. (1984). BLOOD VISCOELASTICITY FOR CONDITIONS OF PHYSIOLOGICAL FLOW IN SMALL ARTERIES. CHEMICAL ENGINEERING COMMUNICATIONS, 30(3-5), 275-284.Informa UK Limited. doi: 10.1080/00986448408911132.

FEDERSPIEL, W.J., & SARELIUS, I.H. (1984). AN EXAMINATION OF THE CONTRIBUTION OF RED-CELL SPACING TO THE UNIFORMITY OF OXYGEN FLUX AT THE CAPILLARY WALL. MICROVASCULAR RESEARCH, 27(3), 273-285.Elsevier BV. doi: 10.1016/0026-2862(84)90059-1.

HONIG, C.R., GAYESKI, T.E.J., FEDERSPIEL, W., CLARK, A., & CLARK, P. (1984). MUSCLE O-2 GRADIENTS FROM HEMOGLOBIN TO CYTOCHROME - NEW CONCEPTS, NEW COMPLEXITIES. ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, 169, 23-38.Springer US. doi: 10.1007/978-1-4684-1188-1_2.

Federspiel, W., & Cokelet, G.R. (1983). Prediction of time dependent blood flow in small glass tubes. Microvasc. Res., 25, (p. 233).

Federspiel, W., Clark Jr, A., & Cokelet, G.R. (1982). Oxygen delivery: the view from the red cell. Microvasc. Res., 23, (p. 251).

Clark Jr, A., Cokelet, G.R., & Federspiel, W. (1981). Erythrocyte motion and oxygen transport. Biblthca. Anat., 20, 385-388.

Madhani, S., May, A., Frankowski, B., Burgreen, G., & Federspiel, W. Blood Recirculation Enhances Oxygenation Efficiency of Artificial Lungs. ASAIO Journal.Lippincott, Williams & Wilkins.

Madhani, S.P., May, A.G., Frankowski, B.J., Burgreen, G.W., & Federspiel, W.J. (2020). Blood Recirculation Enhances Oxygenation Efficiency of Artificial Lungs. 44th ESAO and 7th Biennial IFAO Congress.United States. doi: 10.1097/MAT.0000000000001030.

Dhamotharan, V., Orizondo, R., & Federspiel, W. (2019). A quantitative approach to detection of increased circuit resistance during ECMO. American Society of Artificial Internal Organs (ASAIO) 65th Annual Conference.San Francisco, CA.

Dhamotharan, V., Orizondo, R.A., & Federspiel, W. (2019). A Quantitative Approach to Detection of Increased Circuit Resistance during ECMO. Poster session presented at the meeting of McGowan Institute Scientific Retreat.

Federspiel, W., May, A., & Orizondo, R. (2019). 7-day In Vivo Performance of a Low-Flow Extracorporeal CO2 Removal Device. Poster session presented at the meeting of McGowan Institute Scientific Retreat.

May, A., Orizondo, R., Frankowski, B.J., Kocyildirim, E., D’Cunha, J., & Federspiel, W. (2019). 7-day In Vivo Performance of a Low-Flow Extracorporeal CO2 Removal Device. American Society of Artificial Internal Organs (ASAIO) 65th Annual Conference.San Francisco.

May, A., Orizondo, R.A., Frankowski, B., Wearden, P.D., & Federspiel, W. (2019). Acute In Vivo Performance of a Pediatric Ambulatory Artificial Lung. Poster session presented at the meeting of McGowan Institute Scientific Retreat.

Omecinski, K.S., Frankowski, B.J., & Federspiel, W. (2019). Characterization of Floating Impeller Phenomena in an Integrated HFM bundle and Centrifugal Pump Design. Poster session presented at the meeting of McGowan Institute Scientific Retreat.Pittsburgh, PA.

Orizondo, R.A., May, A., Frankowski, B.J., Burgreen, G., Ye, S., Kocyildirim, E., Wagner, W., D’Cunha, J., Kormos, R., & Federspiel, W. (2019). Pittsburgh Paracorporeal Ambulatory Assist Lung: Progress Towards a Long-Term Wearable Artificial Lung. American Society of Artificial Internal Organs (ASAIO) 65th Annual Conference.San Francisco.

Behrangzade, A., Orizondo, R.A., Kellum, J.A., & Federspiel, W. (2018). Development of a Combined Artificial Lung and Kidney. Poster session presented at the meeting of McGowan Institute Scientific Retreat.Pittsburgh, PA.

May, A., Orizondo, R., Frankowski, B.J., Wearden, P.D., & Federspiel, W. (2018). Acute In Vivo Performance of a Pediatric Ambulatory Artificial Lung. 64th Annual American Society for Artificial Internal Organs (ASAIO) Conference.Washington DC.

May, A.G., Orizondo, R.A., Frankowski, B.J., Wearden, P.D., & Federspiel, W. (2018). Acute In Vivo Performance of a Pediatric Ambulatory Artificial Lung. Poster session presented at the meeting of McGowan Institute Scientific Retreat.Pittsburgh, PA.

Orizondo, R., Madhani, S., May, A., Frankowski, B.J., Ye, S., Kocyildirim, E., Wagner, W., Kormos, R., D’Cunha, J., & Federspiel, W. (2018). Successful 30-day Sheep Studies of a Wearable Pumping Artificial Lung. Poster session presented at the meeting of McGowan Institute Scientific Retreat.Pittsburgh, PA.

Orizondo, R., May, A., Frankowski, B.J., Burgreen, G.W., & Federspiel, W. (2018). In Vitro Characterization of a Modular Pump Lung Capable of Multiple Respiratory Assist Applications. Poster session presented at the meeting of McGowan Institute Scientific Retreat.Pittsburgh, PA.

Orizondo, R.A., Madhani, S.P., May, A., Frankowski, B.J., Burgreen, G.W., Ye, S., Kocyildirim, E., Wagner, W., Kormos, R.L., D'Cunha, J., & Federspiel, W. (2018). 30 Day Sheep Studies of a Wearable Pumping Artificial Lung. 64th Annual American Society for Artificial Internal Organs (ASAIO) Conference.Washington, DC.

Orizondo, R.A., May, A.G., Frankowski, B.J., Burgreen, G.W., & Federspiel, W. (2018). In Vitro Characterization of a Modular Pump Lung Capable of Multiple Respiratory Assist Applications. 64th Annual American Society for Artificial Internal Organs (ASAIO) Conference.Washington, DC.

Richards, E., Federspiel, W., Liu, X., Sharma, A.C., Ghosh, R., & Ye, S. (2018). Advancing a System for Generating Universal Blood Plasma. Poster session presented at the meeting of McGowan Institute Scientific Retreat.Pittsburgh, PA.

Jeffries, R., Frankowski, B., & Federspiel, W. (2017). High Efficiency Respiratory Dialysis at Ultra-Low Blood Flows. Poster session presented at the meeting of McGowan Institute Scientific Retreat.Farmington, PA.

Madhani, S., Ye, S.H., Frankowski, B.J., Burgreen, G.W., Antaki, J.F., May, A., Kormos, R., Wagner, W.R., D’Cunha, J., & Federspiel, W.J. (2017). Chronic In-Vivo Studies of an Integrated Wearable Pump-lung. ASAIO 63rd Annual Conference.Chicago, IL.

Madhani, S., Ye, S.H., Frankowski, B.J., Burgreen, G.W., Antaki, J.F., May, A., Kormos, R., Wagner, W.R., D’Cunha, J., & Federspiel, W.J. (2017). Chronic In-Vivo Studies of an Integrated Wearable Pump-lung. ASAIO 63rd Annual Conference.Chicago, IL.

Madhani, S.P., Ye, S., Frankowski, B.J., Burgreen, G.W., Antaki, J.W., Kormos, R., Wagner, W.R., D’Cunha, J., & Federspiel, W. (2017). Chronic In-Vivo Studies of an Integrated Wearable Pump-lung. 44th ESAO and 7th Biennial IFAO Congress.Vienna, Austria.

Malkin, A., Federspiel, W., Kellum, J., & Singbartl, K. (2017). An Extracorporeal Neutrophil Reprogramming Device for the Treatment of Acute Inflammatory Conditions. Poster session presented at the meeting of McGowan Institute Scientific Retreat.Farmington, PA.

May, A.G., Jeffries, R.G., Frankowski, B.J., & Federspiel, W. (2017). Integrated Low Flow Extracorporeal CO2 Removal Device. Poster session presented at the meeting of 44th ESAO and 7th Biennial IFAO Congress.Vienna, Austria.

Orizondo, R., May, A., Madhani, S., Frankowski, B., Wearden, P., & Federspiel, W. (2017). Pittsburgh Pediatric Ambulatory Lung (P-PAL). Poster session presented at the meeting of McGowan Institute Scientific Retreat.Farmington, PA.

Orizondo, R.A., Gino, G., Sultzbach, G., Madhani, S.P., Frankowski, B.J., & Federspiel, W. (2017). Effects of Hollow Fiber Oscillation on Artificial Lungs. Poster session presented at the meeting of ASAIO 63rd Annual Conference.Chicago, IL.

Orizondo, R.A., Gino, G., Sultzbach, G., Madhani, S.P., Frankowski, B.J., & Federspiel, W. (2017). Effects of Hollow Fiber Oscillation on Artificial Lungs. Poster session presented at the meeting of 44th ESAO and 7th Biennial IFAO Congress.Vienna, Austria.

Orizondo, R.A., May, A., Madhani, S.P., Frankowski, B.J., Burgreen, G.W., Wearden, P.D., & Federspiel, W. (2017). In vitro Characterization and In vivo Performance of the Pittsburgh Pediatric Ambulatory Lung Device. 13th International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion.Rome, Italy.

Orizondo, R.A., May, A.G., Madhani, S.P., Frankowski, B.J., Burgreen, G.W., Wearden, P.D., & Federspiel, W. (2017). In Vitro Characterization of the Pittsburgh Pediatric Ambulatory Lung (P-PAL). 44th ESAO and 7th Biennial IFAO Congress.Vienna, Austria.

Kimmel, J.D., Arazawa, D., & Federspiel, W. (2012). Bioactive Hollow Fiber Membranes Coated with Chitosan and Carbonic Anhydrase for Artificial Lung Applications. Poster session presented at the meeting of University of Pittsburgh Postdoctoral Association 2012 Postdoctoral Data & Dine Symposium.Pittsburgh, PA.

Vodovotz, Y., Valenti, I., Peng, Z., Namas, R., Mi, Q., Kellum, J., Federspiel, W., DiLeo, M., & Barclay, D. (2011). Effects of Hemoadsorption of inflammation in e.coli induced fibrin peritonitis. Society of Critical Care Medicine Annual Meeting.

DiLeo, M.V., & Federspiel, W. (2010). Selective improvement of TNF capture in a cytokine hemoadsorption device using immobilized anti-TNF. Poster session presented at the meeting of University of Pittsburgh Safar Conference.Pittsburgh, PA.

Kimmel, J., Lacko, C., Kellum, J., & Federspiel, W. (2010). TNF Capture Dynamics within Hemoadsorption Beads Used to Treat Sepsis. Poster session presented at the meeting of University of Pittsburgh Safar Conference.Pittsburgh, PA.

Kimmel, J.D., Gibson, G.A., Watkins, S.C., & Federspiel, W. (2009). Dynamics of cytokine capture within hemoadsorption beads used to treat sepsis. BMES Conference.Pittsburgh, PA.

Rothstein, S.N., Federspiel, W., & Little, S. (2008). Towards the Rational Design of Controlled Release Therapeutics. AIChE 2008 Annual Meeting.Philadelphia, PA.

Rothstein, S.N., Federspiel, W., & Little, S. (2008). Towards the Rational Design of Biodegradable Controlled Release Vehicles. AIChE 2008 Annual Meeting.Philadelphia, PA.

Rothstein, S.N., Federspiel, W., & Little, S. (2008). A unified mathematical model for predicting controlled release from surface and bulk eroding matrices without regression. Poster session presented at the meeting of AIChE 2008 Annual Meeting.Philadelphia, PA.

Rothstein, S.N., Federspiel, W., & Little, S. (2008). Towards the Rational Design of Controlled Release Therapeutics. Biotechnology and Bioengineering Research Symposium. Biomedical Engineering Graduate Society Symposium, Carnegie Mellon University.Pittsburgh, PA.

Oh, H.I., Solovan, J.C., Alikhani, A.H., & Federspiel, W. (2005). Design of Specific Antibody Filters to Facilitate ABO-Blood Incompatible Transplantation. Poster session presented at the meeting of McGowan Institute Scientific Retreat.Farmington, PA.

Ghadiali, S.N., Swarts, J.D., Federspiel, W., Banks, J., Karnavas, W., & Doyle, W.J. (2001). Demonstration of eustachian tube compliance using a modified forced response system. Association for Research in Otolaryngology Mid-winter Meeting.St. Petersburg, FL.

Federspiel, W. (1990). Fluid Mechanics in Alveolar Ducts. Annual Fall Meeting of the Biomedical Engineering Society.Blacksburg, VA.

Federspiel, W., Kellum, J., & Singbartl, K. (2019). Devices, Systems And Methods For Cell Modification. 10,258,734.

Federspiel, W., Frankowski, B., Antaki, J., Bermudez, C., Jeffries, R., Wagner, W., & Ye, S. (2018). Extracorporeal ambulator assist lung. 10,080,834.

Jeffries, R., Federspiel, W., & Frankowski, B. (2018). Extracorporeal Gas Exchange Devices, Systems and Methods.

Madhani, S., Frankowski, B., Federspiel, W., Burgreen, G., & Antaki, J. (2018). Extracorporeal Ambulatory Assist Lung.

Madhani, S.P., Frankowski, B.J., Federspiel, W., Burgreen, G., & Antaki, J.F. (2018). Extracorporeal Ambulatory Assist Lung.

Federspiel, W., Arazawa, D., & Kimmel, J. (2017). Devices, Systems And Methods For Reducing The Concentration Of Carbon Dioxide In Blood. 9,814,821.

Federspiel, W., Kellum, J., & Singbartl, K. (2017). Devices, Systems And Methods For Cell Modification.

Federspiel, W., Kellum, J., & Singbartl, K. (2017). Devices, Systems And Methods For Cell Modification.

Madhani, S., Frankowski, B., & Federspiel, W. (2017). Lung Assist Device With Oscillating Fiber Bundle. 15/288,111.

Federspiel, W., Frankowski, B., Yoshida, T., & Vernucci, P. (2016). Oxygen depletion devices and methods for removing oxygen from red blood cells. 9,296,990.

Madhani, S., Frankowski, B., & Federspiel, W. (2016). Lung Assist Device with Oscillating Fiber Bundle.

Madhani, S.P., Frankowski, B.J., & Federspiel, W. (2016). Extracorporeal Ambulator Assist Lung.

Federspiel, W., Arazawa, D.T., & Kimmel, J.D. (2015). Devices, Systems And Methods For Reducing The Concentration Of Carbon Dioxide In Blood. 14/405038.

Federspiel, W., Frankowski, B.J., Antaki, J.F., Bermudez, C., Jeffries, R.G., & Wagner, W.R. (2015). Extracorporeal Ambulator Assist Lung. 14/647,861.

Federspiel, W., Frankowski, B.J., Antaki, J.F., Bermudez, C., Jeffries, R.G., & Wagner, W.R. (2015). Extracorporeal Ambulator Assist Lung.

Jeffries, R.G., Federspiel, W., & Frankowski, B.J. (2015). Extracorporeal Gas Exchange Devices, Systems and Methods.

Jeffries, R.G., Federspiel, W., & Frankowski, B.J. (2015). Extracorporeal Gas Exchange Devices, Systems And Methods.

Kellum, J.A., & Federspiel, W. (2015). Removal of Carbon Dioxide via Dialysis. 14/761,321.

Madhani, S.P., Frankowksi, B.J., & Federspiel, W. (2015). Lung Assist Device with Oscillating Fiber Bundle.

Federspiel, W., Frankowski, B.J., Mack, B.C., Morley, S.W., Rosenberg, M., & Svitek, R.G. (2014). Paracorporeal Respiratory Assist Lung. 8,647,569.

Federspiel, W., Frankowski, B.J., Mack, B.C., Morley, S.W., Rosenberg, M., & Svitek, R.G. (2014). Paracorporeal respiratory assist lung. 13/084100.

Frankowski, B.J., Federspiel, W., Mihelc, K.M., & Lieber, S.C. (2014). Intracorporeal Gas Exchange Devices, Systems and Methods. 8,734,382.

Frankowski, B.J., Federspiel, W., Mihelc, K.M., & Lieber, S.C. (2014). Intracorporeal Gas Exchange Devices, Systems and Methods. 8,734,382.

Kellum, J.A., Federspiel, W., & Cove, M. (2014). Removal of Carbon Dioxide Via Dialysis. PCT/US2014/012151.

Federspiel, W., Arazawa, D.T., & Kimmel, J.D. (2013). Devices, Systems And Methods For Reducing The Concentration Of Carbon Dioxide In Blood. PCT/US2013/046042.

Federspiel, W., Frankowski, B.J., Antaki, J., Bermudez, C., Jeffries, R.G., & Wagner, W.R. (2013). Extracorporeal Ambulator Assist Lung.

Federspiel, W., Frankowski, B.J., Yoshida, T., & Vernucci, P.J. (2013). Oxygen depletion devices and methods for removing oxygen from red blood cells. 14/038,001.

Federspiel, W., Frankowski, B.J., Yoshida, T., & Vernucci, P.J. (2013). Oxygen depletion devices and methods for removing oxygen from red blood cells. 8,569,052.

Kellum, J.A., Federspiel, W., & Cove, M.E. (2013). Removal of Carbon Dioxide Via Dialysis. 61/754,435.

Federspiel, W., Arazawa, D.T., & Kimmel, J.D. (2012). Devices, Systems And Methods For Reducing The Concentration Of Carbon Dioxide In Blood. 61/660,013.

Federspiel, W., Kellum, J.A., & Singbartl, K. (2012). Devices Systems and Methods for Cell Modification. PCT/US2010/051772.

Federspiel, W., Russell, A.J., Oh, H., & Kaar, J. (2012). Devices, systems and methods for reducing the concentration of a chemical entity in fluids. 8,323,379.

Federspiel, W., Yoshida, T., Vernucci, P.J., Frankowski, B.J., & Wheeler Lund, L. (2012). Removal Of Oxygen From Biological Fluids. 13/387,528.

Federspiel, W., Frankowski, B.J., Mack, B.C., Morley, S.W., Rosenberg, M., & Svitek, R.G. (2011). Paracorporeal Respiratory Assist Lung. 7,927,544.

Federspiel, W., Frankowski, B.J., Mack, B.C., Morley, S.W., Rosenberg, M., & Svitek, R.G. (2011). Paracorporeal Respiratory Assist Lung. 13/084100.

Federspiel, W., Frankowski, B.J., Yoshida, T., & Vernucci, P.J. (2011). Oxygen depletion devices and methods for removing oxygen from red blood cells. 13/115,532.

Federspiel, W., Russell, A.J., Oh, H., & Kaar, J. (2011). Devices, systems and methods for reducing the concentration of a chemical entity in fluids. 13/280,033.

Federspiel, W., Russell, A.J., Oh, H., & Kaar, J. (2011). Devices, Systems and Methods for Reducing the Concentration of a Chemical Entity in Fluids. 8,043,411.

Federspiel, W., Kellum, J.A., & Singbartl, K. (2010). Devices Systems and Methods for Cell Modification. 13/500,163.

Federspiel, W., Russell, A.J., Oh, H., & Kaar, J. (2010). Devices, Systems and Methods for Reducing the Concentration of a Chemical Entity in Fluids. 12/816,455.

Federspiel, W., Russell, A.J., Oh, H., & Kaar, J. (2010). Devices, Systems and Methods for Reducing the Concentration of a Chemical Entity in Fluids. 7,763,097.

Federspiel, W., Yoshida, T., Vernucci, P.J., Frankowski, B.J., & Wheeler Lund, L. (2010). Removal of Oxygen from Biological Fluids. 61/230,575.

Federspiel, W., Yoshida, T., Vernucci, P.J., Frankowski, B.J., & Wheeler Lund, L. (2010). Removal of Oxygen from Biological Fluids. PCT/US2010/44045.

Frankowski, B.J., Federspiel, W., Mihelc, K.M., & Lieber, S.C. (2009). Intracorporeal Gas Exchange Devices, Systems and Methods. PCT/US2009/033399.

Frankowski, B.J., Federspiel, W., Mihelc, K.M., & Lieber, S.C. (2009). Intracorporeal Gas Exchange Devices, Systems and Methods. 12/865,958.

Federspiel, W., Russell, A.J., Oh, H., & Kaar, J. (2007). Devices, Systems and Methods for Reducing the Concentration of a Chemical Entity in Fluids. 11,811,265.

Federspiel, W., Russell, A.J., Oh, H., & Kaar, J. (2007). Devices, Systems and Methods for Reducing the Concentration of a Chemical Entity in Fluids. PCT/US2007/013563.

Federspiel, W., Frankowski, B.J., Mack, B.C., Morley, S.W., Rosenberg, M., & Svitek, R.G. (2006). Paracorporeal Respiratory Assist Lung. 11/408,650.

Federspiel, W., Frankowski, B.J., Mack, B.C., Morley, S.W., Rosenberg, M., & Svitek, R.G. (2006). Paracorporeal Respiratory Assist Lung. PCT/US06/15000.

Hattler, B.G., Federspiel, W., & Frankowski, B.J. (2006). Percutaneous Respiratory Assist Catheter Incorporating A Spinning Fiber Bundle. 60/688,861.

Hattler, B.G., Federspiel, W., & Frankowski, B.J. (2006). Percutaneous Respiratory Assist Catheter Incorporating A Spinning Fiber Bundle. PCT/US06/15002.

Frankowski, B.J., Federspiel, W., & Golob Jr., J.F. (2003). Magnetic Guidewires. 10/434,555.

Research interests

Advanced application of fluid...
Cardiovascular and pulmonary...
Combining microfabrication and...
Design and development of membrane...
Design and development of novel...
Developing improved transport...
Development of mathematical and...
Development of oxygen depletion...
Modeling and optimizing artificial...
Respiratory assist and blood...
Respiratory support catheters and...