William Federspiel

  • (2019) Elected as National Academy of Inventors Fellow.
  • (2019) Appointed as John A. Swanson Professor.
  • (2019) 2019 Carnegie Science Award for Life Sciences.
  • (2018) Appointed to Editorial Board: Pediatric Research and Neonatal Care.
  • (2017) Appointed to Education Board, American Health Council.
  • (2016) Elected as an American Health Council Affiliate.
  • (2015) Invited by the Provost's and Chancellor's office to present my translational research experience to the University of Pittsburgh Board of Trustees in a talk entitled, "Respiratory Dialysis: A New Paradigm for Treating Lung Failure".
  • (2014) Certificate of Appreciation for Distinguished Service to the Rehabilitation Research and Development Service Scientific Merit Review Board from the Department of Veterans Affairs.
  • (2014) 2014 Carnegie Science Awards: Honorable Mention in the Start-Up Entrepreneur Award category.
  • (2014) Appointed to Honorary Editorial Board: Advanced Health Care Technologies.
  • (2014) ALung's Hemolung Respiratory Assist System (RAS) Recipient of Gold Award at Medical Design Excellence Awards.
  • (2013) Appointed to Editorial Board: Medical Instrumentation Journal.
  • (2011) Pitt Chronicle, featured in "Spotlight on Research: Charting the Future Through Bioengineering-Innovative ideas for lung disease and sepsis".
  • (2011) Member, American Institute for Medical Biological Engineering (AIMBE), Advocacy Committee.
  • (2011) Regular Member, Department of Veterans Affairs: Rehabilitation Research and Development Service.
  • (2010) Morning Journal, featured in "Emerging Technology May Help Patients Avoid Ventilators and Their Complications. Presented at: Morning Journal".
  • (2010) Top Ten MedGadget Award 2010: Alung's Hemolung Device.
  • (2009) Chair, Graduate Committee, Department of Bioengineering, University of Pittsburgh.
  • (2009 - 2013) Regular Member, NIH Study Section: Bioengineering, Technology and Surgical Sciences Study Section (BTSS).
  • (2008) Ad Hoc Member, NIH Study Section: Surgical Sciences, Biomedical Imaging and Bioengineering Integrated Review Group.
  • (2008) Appointed to Honorary Editorial Board: Medical Devices: Evidence and Research.
  • (2008) Chair, NIH Special Emphasis Review panel: Bioengineering Research Applications; Respiratory Sciences.
  • (2008) Appointed Member, International Scientific Advisory Committee for Biomed 2009.
  • (2007) New Scientist, featured in "A slimming treatment for artificial lungs".
  • (2007) Ad Hoc Member, NIH Study Section: Surgical Sciences, Biomedical Imaging and Bioengineering Integrated Review Group.
  • (2007) Elected Fellow, Biomedical Engineering Society (BMES).
  • (2007) Appointed to Editorial Board, Organogenesis.
  • (2006) Member, NIH Special Emphasis Panel: Bioengineering Research Applications: Respiratory.
  • (2006) Member, NIH Special Emphasis Panel: T1 Bioengineering Training Grants.
  • (2006) Member, NIH Special Emphasis Panel: BRP: Respiratory.
  • (2006) Member, NIH Special Emphasis Panel: Kidney Dialysis, Monitoring and Therapeutics.
  • (2006) Board of Visitors Award, School of Engineering, University Of Pittsburgh.
  • (2005) IEEE Spectrum, Profiled in story: "The Body Shops".
  • (2005) Appointed as William Kepler Whiteford Professor.
  • (2005) Ad Hoc Member, NIH Study Section, Vascular Cell and Molecular Biology.
  • (2005) Member, NIH Special Emphasis Review Panel: Bioengineering Research Applications: Respiratory Sciences.
  • (2004) Ad Hoc Member, NIH Study Section, Vascular Cell and Molecular Biology.
  • (2004) Appointed Section Editor, Bioengineering, ASAIO Journal.
  • (2003) World Technology Award for Health & Medicine, nominated.
  • (2003) Ad Hoc Member, NIH Study Section, Experimental Cardiovascular Services.
  • (2003 - 2005) Awarded CNG Faculty Fellowship, University of Pittsburgh.
  • (2002) Chemical and Engineering News, Profiled in story: "Pittsburgh Rising".
  • (2002) Invited Speaker: Pittsburgh Leadership Conference.
  • (2002) Ad Hoc Member, NIH Study Section, Experimental Cardiovascular Sciences.
  • (2002) Discover Magazine, featured in "100 top science stories of 2000".
  • (2001) New Scientist, featured in "Take a Breather".
  • (2001) USA Today, featured in "Artificial lung device holds breath of hope".
  • (2001) Ad Hoc Member, NIH Study Section, Surgery and Bioengineering.
  • (2001) Unrestricted Research Gift from Mallinckrodt Inc.: $25,000.
  • (2000) Ad Hoc Member, NIH Study Section, Lung Biology and Pathology.
  • (1999) Ad Hoc Member, NIH Study Section, Experimental Cardiovascular Sciences.
  • (1999) Ad Hoc Member, NIH Study Section, Surgery and Bioengineering.
  • (1999) Elected Fellow, American Institute for Medical and Biological Engineering.
  • (1998) Ad Hoc Member, NIH Study Section, Surgery and Bioengineering.
  • (1989) NIH Special Study Section Site Visit Team, RR01243, University of Washington.
  • (1986 - 1989) NIH New Investigator Research Award.
  • (1979 - 1982) NIH National Research Service Award.
  • (1978 - 1979) Shell Fellowship Award.
  • (1974 - 1978) Rochester Engineering Scholarship.

  • Ph.D., Chemical Engineering, University of Rochester, 1983
  • M.S., Chemical Engineering, University of Rochester, 1980
  • B.S., Chemical Engineering, University of Rochester, 1978

  • Ye, S.H., Orizondo, R.A., De, B.N., Kim, S., Frankowski, B.J., Federspiel, W.J., & Wagner, W.R. (2024). Epoxy silane sulfobetaine block copolymers for simple, aqueous thromboresistant coating on ambulatory assist lung devices. J Biomed Mater Res A, 112(1), 99-109.Wiley. doi: 10.1002/jbm.a.37619.
  • Omecinski, K.S., Frankowski, B.J., & Federspiel, W.J. (2023). Design and In Vitro Evaluation of an Artificial Placenta Made From Hollow Fiber Membranes. ASAIO J, 69(2), e86-e92.Wolters Kluwer. doi: 10.1097/MAT.0000000000001862.
  • Sanatkhani, S., Nedios, S., Menon, P.G., Saba, S.F., Jain, S.K., Federspiel, W.J., & Shroff, S.G. (2023). Subject-specific factors affecting particle residence time distribution of left atrial appendage in atrial fibrillation: A computational model-based study. Front Cardiovasc Med, 10, 1070498.Frontiers. doi: 10.3389/fcvm.2023.1070498.
  • Orizondo, R.A., Omecinski, K.S., May, A.G., Dhamotharan, V., Frankowski, B.J., Burgreen, G.W., Ye, S.H., Kocyildirim, E., Sanchez, P.G., D'Cunha, J., Wagner, W.R., & Federspiel, W.J. (2021). Month-long Respiratory Support by a Wearable Pumping Artificial Lung in an Ovine Model. Transplantation, 105(5), 999-1007.Wolters Kluwer. doi: 10.1097/TP.0000000000003481.
  • Cove, M.E., Vu, L.H., Ring, T., Federspiel, W.J., & Kellum, J.A. (2020). Respiratory Dialysis-A Novel Low Bicarbonate Dialysate to Provide Extracorporeal CO2 Removal. Crit Care Med, 48(7), e592-e598.Wolters Kluwer. doi: 10.1097/CCM.0000000000004351.
  • May, A.G., Omecinski, K.S., Frankowski, B.J., & Federspiel, W.J. (2020). Effect of Hematocrit on the CO2 Removal Rate of Artificial Lungs. ASAIO J, 66(10), 1161-1165.Wolters Kluwer. doi: 10.1097/MAT.0000000000001140.
  • May, A.G., Orizondo, R.A., Frankowski, B.J., Ye, S.H., Kocyildirim, E., Wagner, W.R., D'Cunha, J., & Federspiel, W.J. (2020). In vivo testing of the low-flow CO2 removal application of a compact, platform respiratory device. Intensive Care Med Exp, 8(1), 45.Springer Nature. doi: 10.1186/s40635-020-00329-9.
  • Cove, M.E., Vu, L.H., Ring, T., May, A.G., Federspiel, W.J., & Kellum, J.A. (2019). A Proof of Concept Study, Demonstrating Extracorporeal Carbon Dioxide Removal Using Hemodialysis with a Low Bicarbonate Dialysate. ASAIO J, 65(6), 605-613.Wolters Kluwer. doi: 10.1097/MAT.0000000000000879.
  • Madhani, S.P., Frankowski, B.J., Ye, S.H., Burgreen, G.W., Wagner, W.R., Kormos, R., D'Cunha, J., & Federspiel, W.J. (2019). In Vivo 5 Day Animal Studies of a Compact, Wearable Pumping Artificial Lung. ASAIO J, 65(1), 94-100.Wolters Kluwer. doi: 10.1097/MAT.0000000000000740.
  • May, A.G., Orizondo, R.A., Frankowski, B.J., Wearden, P.D., & Federspiel, W.J. (2019). Acute In Vivo Evaluation of the Pittsburgh Pediatric Ambulatory Lung. ASAIO J, 65(4), 395-400.Wolters Kluwer. doi: 10.1097/MAT.0000000000000918.
  • Vu, L.H., Kellum, J.A., Federspiel, W.J., & Cove, M.E. (2019). Carbon dioxide removal using low bicarbonate dialysis in rodents. Perfusion, 34(7), 578-583.SAGE Publications. doi: 10.1177/0267659119839284.
  • Harter, T.S., May, A.G., Federspiel, W.J., Supuran, C.T., & Brauner, C.J. (2018). Time course of red blood cell intracellular pH recovery following short-circuiting in relation to venous transit times in rainbow trout, Oncorhynchus mykiss. Am J Physiol Regul Integr Comp Physiol, 315(2), R397-R407.American Physiological Society. doi: 10.1152/ajpregu.00062.2018.
  • Malkin, A.D., Ye, S.H., Lee, E.J., Yang, X., Zhu, Y., Gamble, L.J., Federspiel, W.J., & Wagner, W.R. (2018). Development of zwitterionic sulfobetaine block copolymer conjugation strategies for reduced platelet deposition in respiratory assist devices. J Biomed Mater Res B Appl Biomater, 106(7), 2681-2692.Wiley. doi: 10.1002/jbm.b.34085.
  • May, A.G., Jeffries, R.G., Frankowski, B.J., Burgreen, G.W., & Federspiel, W.J. (2018). Bench Validation of a Compact Low-Flow CO2 Removal Device. Intensive Care Med Exp, 6(1), 34.Springer Nature. doi: 10.1186/s40635-018-0200-7.
  • Orizondo, R., Gino, G., Sultzbach, G., Madhani, S., Frankowski, B., & Federspiel, W. (2018). Effects of Hollow Fiber Membrane Oscillation on an Artificial Lung. Annals of Biomedical Engineering, 46(5), 762-771.Springer Verlag. doi: 10.1007/s10439-018-1995-9.
  • Orizondo, R.A., May, A.G., Madhani, S.P., Frankowski, B.J., Burgreen, G.W., Wearden, P.D., & Federspiel, W.J. (2018). In Vitro Characterization of the Pittsburgh Pediatric Ambulatory Lung. ASAIO J, 64(6), 806-811.Wolters Kluwer. doi: 10.1097/MAT.0000000000000711.
  • Jeffries, R.G., Lund, L., Frankowski, B., & Federspiel, W.J. (2017). An extracorporeal carbon dioxide removal (ECCO2R) device operating at hemodialysis blood flow rates. Intensive Care Med Exp, 5(1), 41.Springer Nature. doi: 10.1186/s40635-017-0154-1.
  • Madhani, S.P., Frankowski, B.J., & Federspiel, W.J. (2017). Fiber Bundle Design for an Integrated Wearable Artificial Lung. ASAIO J, 63(5), 631-636.Wolters Kluwer. doi: 10.1097/MAT.0000000000000542.
  • Madhani, S.P., Frankowski, B.J., Burgreen, G.W., Antaki, J.F., Kormos, R., D'Cunha, J., & Federspiel, W.J. (2017). In vitro and in vivo evaluation of a novel integrated wearable artificial lung. J Heart Lung Transplant, 36(7), 806-811.Elsevier. doi: 10.1016/j.healun.2017.02.025.
  • May, A.G., Sen, A., Cove, M.E., Kellum, J.A., & Federspiel, W.J. (2017). Extracorporeal CO2 removal by hemodialysis: in vitro model and feasibility. Intensive Care Med Exp, 5(1), 20.Springer Nature. doi: 10.1186/s40635-017-0132-7.
  • Madhani, S.P., D'Aloiso, B.D., Frankowski, B., & Federspiel, W.J. (2016). Darcy Permeability of Hollow Fiber Membrane Bundles Made from Membrana Polymethylpentene Fibers Used in Respiratory Assist Devices. ASAIO J, 62(3), 329-331.Wolters Kluwer. doi: 10.1097/MAT.0000000000000348.
  • Nguyen, J., Malkin, A., & Federspiel, W. (2016). New chemical methods developed on prototypes with hopes to improve gas exchange within respiratory devices. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 251.
  • Parker, R.S., Hogg, J.S., Roy, A., Kellum, J.A., Rimmelé, T., Daun-Gruhn, S., Fedorchak, M.V., Valenti, I.E., Federspiel, W.J., Rubin, J., Vodovotz, Y., Lagoa, C., & Clermont, G. (2016). Modeling and Hemofiltration Treatment of Acute Inflammation. Processes (Basel), 4(4), 38.MDPI. doi: 10.3390/pr4040038.
  • Arazawa, D.T., Kimmel, J.D., & Federspiel, W.J. (2015). Kinetics of CO2 exchange with carbonic anhydrase immobilized on fiber membranes in artificial lungs. J Mater Sci Mater Med, 26(6), 193.Springer Nature. doi: 10.1007/s10856-015-5525-0.
  • Arazawa, D.T., Kimmel, J.D., Finn, M.C., & Federspiel, W.J. (2015). Acidic sweep gas with carbonic anhydrase coated hollow fiber membranes synergistically accelerates CO2 removal from blood. Acta Biomaterialia, 25, 143-149.Elsevier. doi: 10.1doi:10.1016/j.actbio.2015.07.007016/j.actbio.2015.07.007.
  • Cook, K.E., Maul, T.M., & Federspiel, W.J. (2015). Artificial Lungs. In The Biomedical Engineering Handbook: Molecular, Cellular, and Tissue Engineering, Bronzino, J.D., & Peterson, D.R. (Eds.). (p. 78-1).CRC Press.
  • Cove, M.E., & Federspiel, W.J. (2015). Veno-venous extracorporeal CO2 removal for the treatment of severe respiratory acidosis. Crit Care, 19(1), 176.Springer Nature. doi: 10.1186/s13054-015-0769-0.
  • Madhani, S., & Federspiel, W.J. (2015). Letter to the Editor on: "Darcy permeability of hollow fiber bundles used in blood oxygenation devices" [J. Membr. Sci. 382 (2011) 238-242]. JOURNAL OF MEMBRANE SCIENCE, 496, 359-360.Elsevier. doi: 10.1016/j.memsci.2015.09.012.
  • Malkin, A.D., Sheehan, R.P., Mathew, S., Federspiel, W.J., Redl, H., & Clermont, G. (2015). A Neutrophil Phenotype Model for Extracorporeal Treatment of Sepsis. In Tan, K. (Ed.). PLoS Comput Biol, 11(10), e1004314.Public Library of Science (PLoS). doi: 10.1371/journal.pcbi.1004314.
  • Ye, S.H., Arazawa, D.T., Zhu, Y., Shankarraman, V., Malkin, A.D., Kimmel, J.D., Gamble, L.J., Ishihara, K., Federspiel, W.J., & Wagner, W.R. (2015). Hollow fiber membrane modification with functional zwitterionic macromolecules for improved thromboresistance in artificial lungs. Langmuir, 31(8), 2463-2471.American Chemical Society (ACS). doi: 10.1021/la504907m.
  • Zhang, J., Peng, Z., Maberry, D., Volpe, J., Kimmel, J.D., Federspiel, W.J., & Kellum, J.A. (2015). Effects of hemoadsorption with a novel adsorbent on sepsis: in vivo and in vitro study. Blood Purif, 39(1-3), 239-245.Karger Publishers. doi: 10.1159/000381006.
  • Jeffries, R.G., Frankowski, B.J., Burgreen, G.W., & Federspiel, W.J. (2014). Effect of impeller design and spacing on gas exchange in a percutaneous respiratory assist catheter. Artif Organs, 38(12), 1007-1017.Wiley. doi: 10.1111/aor.12308.
  • Jeffries, R.G., Mussin, Y., Bulanin, D.S., Lund, L.W., Kocyildirim, E., Zhumadilov, Z.Z., Olzhayev, F.S., Federspiel, W.J., & Wearden, P.D. (2014). Pre-clinical evaluation of an adult extracorporeal carbon dioxide removal system with active mixing for pediatric respiratory support. Int J Artif Organs, 37(12), 888-899.SAGE Publications. doi: 10.5301/ijao.5000372.
  • Mussin, Y., Jeffries, R., Bulanin, D., Zhumadilov, Z., Olzhayev, F., & Federspiel, W. (2014). Pre-clinical Evaluation of an Adult Extracoproreal Carbon Dioxide Removal System for Pediatric Application. Cent Asian J Glob Health, 3(Suppl), 167.University Library System, University of Pittsburgh. doi: 10.5195/cajgh.2014.167.
  • Peng, Z.Y., Bishop, J.V., Wen, X.Y., Elder, M.M., Zhou, F., Chuasuwan, A., Carter, M.J., Devlin, J.E., Kaynar, A.M., Singbartl, K., Pike, F., Parker, R.S., Clermont, G., Federspiel, W.J., & Kellum, J.A. (2014). Modulation of chemokine gradients by apheresis redirects leukocyte trafficking to different compartments during sepsis, studies in a rat model. Crit Care, 18(4), R141.Springer Nature. doi: 10.1186/cc13969.
  • Sen, A., Kellum, J., & Federspiel, W. (2014). EXTRACORPOREAL CARBON-DIOXIDE REMOVAL IS FEASIBLE USING A ZERO BICARBONATE DIALYSATE. CRITICAL CARE MEDICINE, 42.Wolters Kluwer. doi: 10.1097/01.ccm.0000458168.22241.90.
  • Kimmel, J.D., Arazawa, D.T., Ye, S.H., Shankarraman, V., Wagner, W.R., & Federspiel, W.J. (2013). Carbonic anhydrase immobilized on hollow fiber membranes using glutaraldehyde activated chitosan for artificial lung applications. J Mater Sci Mater Med, 24(11), 2611-2621.Springer Nature. doi: 10.1007/s10856-013-5006-2.
  • Lund, L.W., & Federspiel, W.J. (2013). Removing extra CO2 in COPD patients. Curr Respir Care Rep, 2(3), 131-138.Springer Nature. doi: 10.1007/s13665-013-0057-x.
  • Rimmelé, T., Kaynar, A.M., McLaughlin, J.N., Bishop, J.V., Fedorchak, M.V., Chuasuwan, A., Peng, Z., Singbartl, K., Frederick, D.R., Zhu, L., Carter, M., Federspiel, W.J., Zeevi, A., & Kellum, J.A. (2013). Leukocyte capture and modulation of cell-mediated immunity during human sepsis: an ex vivo study. Crit Care, 17(2), R59.Springer Nature. doi: 10.1186/cc12587.
  • Sen, A., Kellum, J.A., & Federspiel, W.J. (2013). Extracorporeal Carbon Dioxide Removal By Zero Bicarbonate Dialysate: A Novel Lung Protection Strategy. Critical Care Medicine, 41, (p. A47).Wolters Kluwer. doi: 10.1097/01.ccm.0000439357.52072.a2.
  • Alikhani, A., & Federspiel, W.J. (2012). Selective capture of anti-A antibodies from human blood using a novel integrated bead and hollow fiber module. J Biomed Mater Res B Appl Biomater, 100(8), 2114-2121.Wiley. doi: 10.1002/jbm.b.32776.
  • Alikhani, A., & Federspiel, W.J. (2012). Selective capture of anti-A antibodies from human blood using a novel integrated bead and hollow fiber module. Journal of biomedical materials research. Part B, Applied biomaterials, 100(8), 2114-2121. doi: 10.1002/jbm.b.32776.
  • Arazawa, D.T., Oh, H.I., Ye, S.H., Johnson, C.A., Woolley, J.R., Wagner, W.R., & Federspiel, W.J. (2012). Immobilized Carbonic Anhydrase on Hollow Fiber Membranes Accelerates CO(2) Removal from Blood. J Memb Sci, 404-404, 25-31.Elsevier. doi: 10.1016/j.memsci.2012.02.006.
  • Cove, M., Sen, A., Federspiel, W., & Kellum, J. (2012). "RESPIRATORY DIALYSIS": A NOVEL APPROACH FOR ENABLING LUNG PROTECTIVE VENTILATION. CRITICAL CARE MEDICINE, 40, (p. U277).
  • Cove, M.E., MacLaren, G., Federspiel, W.J., & Kellum, J.A. (2012). Bench to bedside review: Extracorporeal carbon dioxide removal, past present and future. Crit Care, 16(5), 232.Springer Nature. doi: 10.1186/cc11356.
  • Federspiel, W.J., & Valenti, I. (2012). On Laminar Flow in Microfabricated Channels with Partial Semi-Circular Profiles. Open Journal of Applied Sciences, 02(01), 28-34.Scientific Research Publishing. doi: 10.4236/ojapps.2012.21003.
  • Fisher, J.D., DiLeo, M.V., & Federspiel, W.J. (2012). Investigating Cytokine Binding Using a Previously Reported TNF-Specific Aptamer. Open Journal of Applied Sciences, 02(03), 135-138.Scientific Research Publishing. doi: 10.4236/ojapps.2012.23019.
  • Namas, R.A., Namas, R., Lagoa, C., Barclay, D., Mi, Q., Zamora, R., Peng, Z., Wen, X., Fedorchak, M.V., Valenti, I.E., Federspiel, W.J., Kellum, J.A., & Vodovotz, Y. (2012). Hemoadsorption reprograms inflammation in experimental gram-negative septic peritonitis: insights from in vivo and in silico studies. Mol Med, 18(1), 1366-1374.Springer Nature. doi: 10.2119/molmed.2012.00106.
  • Peng, Z.Y., Wang, H.Z., Carter, M.J., Dileo, M.V., Bishop, J.V., Zhou, F.H., Wen, X.Y., Rimmelé, T., Singbartl, K., Federspiel, W.J., Clermont, G., & Kellum, J.A. (2012). Acute removal of common sepsis mediators does not explain the effects of extracorporeal blood purification in experimental sepsis. Kidney Int, 81(4), 363-369.Elsevier. doi: 10.1038/ki.2011.320.
  • Wearden, P.D., Federspiel, W.J., Morley, S.W., Rosenberg, M., Bieniek, P.D., Lund, L.W., & Ochs, B.D. (2012). Respiratory dialysis with an active-mixing extracorporeal carbon dioxide removal system in a chronic sheep study. Intensive Care Med, 38(10), 1705-1711.Springer Nature. doi: 10.1007/s00134-012-2651-8.
  • Alikhani, A., & Federspiel, W.J. (2011). Theoretical and experimental analysis of anti-A antibody capture in novel integrated bead and hollow fiber modules. Ann Biomed Eng, 39(3), 953-963.Springer Nature. doi: 10.1007/s10439-010-0233-x.
  • Batchinsky, A.I., Jordan, B.S., Regn, D., Necsoiu, C., Federspiel, W.J., Morris, M.J., & Cancio, L.C. (2011). Respiratory dialysis: reduction in dependence on mechanical ventilation by venovenous extracorporeal CO2 removal. Crit Care Med, 39(6), 1382-1387.Wolters Kluwer. doi: 10.1097/CCM.0b013e31820eda45.
  • DiLeo, M.V., Fisher, J.D., Burton, B.M., & Federspiel, W.J. (2011). Selective improvement of tumor necrosis factor capture in a cytokine hemoadsorption device using immobilized anti-tumor necrosis factor. J Biomed Mater Res B Appl Biomater, 96(1), 127-133.Wiley. doi: 10.1002/jbm.b.31748.
  • Kimmel, J.D., Harbert, E.M., Parker, R.S., & Federspiel, W.J. (2011). Modeling competitive cytokine adsorption dynamics within hemoadsorption beads used to treat sepsis. J Chromatogr A, 1218(44), 8013-8020.Elsevier. doi: 10.1016/j.chroma.2011.09.007.
  • Kimmel, J.D., Lacko, C.S., Delude, R.L., & Federspiel, W.J. (2011). Characterizing accelerated capture of deoligomerized TNF within hemoadsorption beads used to treat sepsis. J Biomed Mater Res B Appl Biomater, 98(1), 47-53.Wiley. doi: 10.1002/jbm.b.31830.
  • Kimmel, J.D., Lacko, C.S., Delude, R.L., & Federspiel, W.J. (2011). ACCELERATED REMOVAL OF TNF WITHIN A HEMOADSORPTION DEVICE USED TO TREAT SEPSIS. INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 34, (p. 640).
  • Pacella, H.E., Eash, H.J., & Federspiel, W.J. (2011). Darcy Permeability of Hollow Fiber Bundles Used in Blood Oxygenation Devices. J Memb Sci, 382(1-2), 238-242.Elsevier. doi: 10.1016/j.memsci.2011.08.012.
  • Burki, N.K., Bieniek, P.D., Federspiel, W., Morley, S.W., Ochs, B.D., & Wearden, P.D. (2010). Efficacy of Extracorporeal CO2 Removal with the Hemolung: Results in Animals. Am J Respir Crit Care Med, 181.
  • Dileo, M.V., & Federspiel, W.J. (2010). Scaling issues in the article entitled "cytokines in blood from septic patients interact with surface-immobilized heparin". ASAIO J, 56(4), 383-384.Wolters Kluwer. doi: 10.1097/MAT.0b013e3181e4bfc3.
  • Gautam, S., Korchagina, E.Y., Bovin, N.V., & Federspiel, W.J. (2010). Specific antibody filter (SAF) binding capacity enhancement to remove anti-A antibodies. J Biomed Mater Res B Appl Biomater, 95(2), 475-480.Wiley. doi: 10.1002/jbm.b.31707.
  • Kimmel, J.D., Gibson, G.A., Watkins, S.C., Kellum, J.A., & Federspiel, W.J. (2010). IL-6 adsorption dynamics in hemoadsorption beads studied using confocal laser scanning microscopy. J Biomed Mater Res B Appl Biomater, 92(2), 390-396.Wiley. doi: 10.1002/jbm.b.31527.
  • Kimmel, J.D., Lacko, C.S., Delude, R.L., & Federspiel, W.J. (2010). Dynamics of TNF capture within hemoadsorption beads used to treat sepsis. ASME 2010 Summer Bioengineering Conference, SBC 2010, (pp. 85-86).ASME International.Lake Tahoe, CA. doi: 10.1115/SBC2010-19242.
  • Oh, H.I., Ye, S.H., Johnson, C.A., Woolley, J.R., Federspiel, W.J., & Wagner, W.R. (2010). Hemocompatibility assessment of carbonic anhydrase modified hollow fiber membranes for artificial lungs. Artif Organs, 34(5), 439-442.Wiley. doi: 10.1111/j.1525-1594.2009.00882.x.
  • Polk, A.A., Maul, T.M., McKeel, D.T., Snyder, T.A., Lehocky, C.A., Pitt, B., Stolz, D.B., Federspiel, W.J., & Wagner, W.R. (2010). A biohybrid artificial lung prototype with active mixing of endothelialized microporous hollow fibers. Biotechnol Bioeng, 106(3), 490-500.Wiley. doi: 10.1002/bit.22675.
  • Alikhani, A., Korchagina, E.Y., Chinarev, A.A., Bovin, N.V., & Federspiel, W.J. (2009). High molecular weight blood group A trisaccharide-polyacrylamide glycoconjugates as synthetic blood group A antigens for anti-A antibody removal devices. J Biomed Mater Res B Appl Biomater, 91(2), 845-854.Wiley. doi: 10.1002/jbm.b.31466.
  • Budilarto, S.G., Frankowski, B.J., Hattler, B.G., & Federspiel, W.J. (2009). Flow visualization study of a novel respiratory assist catheter. Artif Organs, 33(6), 411-418.Wiley. doi: 10.1111/j.1525-1594.2009.00751.x.
  • Burgess, K.A., Hu, H.H., Wagner, W.R., & Federspiel, W.J. (2009). Towards microfabricated biohybrid artificial lung modules for chronic respiratory support. Biomed Microdevices, 11(1), 117-127.Springer Nature. doi: 10.1007/s10544-008-9215-2.
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  • Federspiel, W., Walters, F., Hewitt, T., Hout, M., Lund, L., Sawzik, P., Reeder, G., Borovetz, H., & Hattler, B.G. (1996). Recent progress in engineering the Pittsburgh intravenous membrane oxygenator. ASAIO Journal, 42, (p. 71).
  • Federspiel, W., Walters, F.R., Hewitt, T., Hout, M.S., Lund, L., & Hattler, B.G. (1996). Further development of an intravenous membrane oxygenator with active mixing. Ann. Biomed. Eng., 24, (p. S6).
  • Federspiel, W.J., & Hattler, B.G. (1996). Sweep gas flow-rate and CO2 exchange in artificial lungs. ARTIFICIAL ORGANS, 20(9), 1050-1052.Wiley. doi: 10.1111/j.1525-1594.1996.tb04593.x.
  • Federspiel, W.J., Hewitt, T., Hout, M.S., Walters, F.R., Lund, L.W., Sawzik, P.J., Reeder, G., Borovetz, H.S., & Hattler, B.G. (1996). Recent progress in engineering the Pittsburgh intravenous membrane oxygenator. ASAIO J, 42(5), M435-M442.Wolters Kluwer. doi: 10.1097/00002480-199609000-00026.
  • Federspiel, W.J., Williams, J.L., & Hattler, B.G. (1996). Gas flow dynamics in hollow-fiber membranes. AICHE JOURNAL, 42(7), 2094-2099.Wiley. doi: 10.1002/aic.690420732.
  • Hout, M.S., Hattler, B.G., & Federspiel, W. (1996). A simple model of flow dependent CO2 exchange in artificial lungs. Ann. Biomed. Eng., 24, (p. S8).
  • Konishi, R., Firestone, W., Wagner, W., Federspiel, W., Konishi, H., Shimizu, R., & Hattler, B.G. (1996). Nitric oxide presents human platelet adhesion on fiber membrane in whole blood. ASAIO Journal, 42, (p. 72).Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/00002480-199604000-00270.
  • Konishi, R., Shimizu, R., Firestone, L., Walters, F.R., Wagner, W.R., Federspiel, W.J., Konishi, H., & Hattler, B.G. (1996). Nitric oxide prevents human platelet adhesion to fiber membranes in whole blood. ASAIO J, 42(5), M850-M853.Wolters Kluwer. doi: 10.1097/00002480-199609000-00111.
  • Lund, L., Federspiel, W., Taitel, F., & Hattler, B.G. (1996). A novel method for measuring hollow fiber membrane permeability in a gas-liquid system. ASAIO Journal, 42, (p. 67).
  • Lund, L.W., Federspiel, W., & Hattler, B.G. (1996). Hollow fiber membrane permeability evaluation for use in intracorporeal artificial lungs. Ann. Biomed. Eng., 24, (p. S8).
  • Lund, L.W., Federspiel, W.J., & Hattler, B.G. (1996). Gas permeability of hollow fiber membranes in a gas-liquid system. JOURNAL OF MEMBRANE SCIENCE, 117(1-2), 207-219.Elsevier. doi: 10.1016/0376-7388(96)00064-6.
  • Lund, L.W., Federspiel, W.J., Walters, F.R., & Hattler, B.G. (1996). A novel method for measuring hollow fiber membrane permeability in a gas-liquid system. ASAIO J, 42(5), M446-M451.Wolters Kluwer. doi: 10.1097/00002480-199609000-00028.
  • Macha, M., Federspiel, W., Lund, L., Sawzik, P., Litwak, P., Borovetz, H., Walters, F., Reeder, G., & Hattler, B.G. (1996). Acute in-vivo studies of the Pittsburgh intravenous membrane oxygenator. ASAIO Journal, 42, (p. 69).
  • Macha, M., Federspiel, W.J., Lund, L.W., Sawzik, P.J., Litwak, P., Walters, F.R., Reeder, G.D., Borovetz, H.S., & Hattler, B.G. (1996). Acute in vivo studies of the Pittsburgh intravenous membrane oxygenator. ASAIO J, 42(5), M609-M615.Wolters Kluwer. doi: 10.1097/00002480-199609000-00060.
  • Vorp, D.A., Federspiel, W.J., & Webster, M.W. (1996). Does laminated intraluminal thrombus within abdominal aortic aneurysm cause anoxia of the aortic wall?. J Vasc Surg, 23(3), 540-541.Elsevier. doi: 10.1016/s0741-5214(96)80027-9.
  • CHAMMAS, P., FEDERSPIEL, W.J., & EISENBERG, S.R. (1994). A MICROCONTINUUM MODEL OF ELECTROKINETIC COUPLING IN THE EXTRACELLULAR-MATRIX - PERTURBATION FORMULATION AND SOLUTION. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 168(2), 526-538.Elsevier. doi: 10.1006/jcis.1994.1451.
  • Federspiel, W.J., & Malai, K. (1993). Model experiments on measuring flow in microvessels using tracers. Microvasc Res, 46(3), 333-350.Elsevier. doi: 10.1006/mvre.1993.1057.
  • Weibel, E.R., Federspiel, W.J., Fryder-Doffey, F., Hsia, C.C., König, M., Stalder-Navarro, V., & Vock, R. (1993). Morphometric model for pulmonary diffusing capacity. I. Membrane diffusing capacity. Respir Physiol, 93(2), 125-149.Elsevier. doi: 10.1016/0034-5687(93)90001-q.
  • Bunk, D.A., Federspiel, W.J., & Jackson, A.C. (1992). Influence of bifurcations on forced oscillations in an airway model. J Biomech Eng, 114(2), 216-221.ASME International. doi: 10.1115/1.2891374.
  • FEDERSPIEL, W.J. (1992). ANALYSIS OF EFFECTIVE AXIAL DIFFUSION IN BRANCHING NETWORKS. AICHE JOURNAL, 38(10), 1631-1638.Wiley. doi: 10.1002/aic.690381013.
  • Lai, J., Federspiel, W., Butler, J.P., & Loring, S.H. (1992). A computational study of pleural pressure induced by lung motion. FASEB Journal, 6, (p. A1480).
  • Malai, K.P., & Federspiel, W. (1992). Use of tracers to measure flow in branching microvessels. FASEB Journal, 6, (p. A2079).
  • Federspiel, W. (1991). On the trumpet model of acinar gas transport. In Advances in Biological Heat and Mass Transfer, McGrath, J.J. (Ed.). 18, (pp. 39-42).ASME Bioengineering Division.
  • TSUDA, A., FEDERSPIEL, W.J., GRANT, P.A., & FREDBERG, J.J. (1991). AXIAL-DISPERSION OF INERT SPECIES IN ALVEOLATED CHANNELS. CHEMICAL ENGINEERING SCIENCE, 46(5-6), 1419-1426.Elsevier. doi: 10.1016/0009-2509(91)85068-9.
  • Federspiel, W. (1990). Use of tracers to measure plasma flow within individual microvessels. FASEB Journal, 4, (p. A1251).
  • Federspiel, W. (1990). Nonclassical features of gas transport and exchange at the alveolar level. In Respiratory Biomechanics: Engineering Analysis of Structure and Function, Farrell-Epstein, M.A., & Ligas, J.R. (Eds.). (pp. 90-97).Springer Verlag.
  • Federspiel, W. (1990). Fluid mechanics in alveolar ducts. In Biofluid Mechanics 3, Schneck, D.J., & Lucas, C.L. (Eds.). (pp. 21-25).New York University Press.
  • Federspiel, W.J. (1990). Use of tracers to measure flow within single microvessels. Microvasc Res, 40(3), 394-411.Elsevier. doi: 10.1016/0026-2862(90)90035-p.
  • Federspiel, W.J. (1989). Pulmonary diffusing capacity: implications of two-phase blood flow in capillaries. Respir Physiol, 77(1), 119-134.Elsevier. doi: 10.1016/0034-5687(89)90035-2.
  • Tsuda, A., Federspiel, W., Grant Jr, P.A., & Fredberg, J.J. (1989). Axial dispersion of inert species in alveolated ducts. Fed. Proc., 3, (p. A686).
  • Federspiel, W. (1988). Influence of the particulate nature of blood on pulmonary oxygen exchange. The Physiologist, 31, (p. A170).
  • Federspiel, W.J., & Fredberg, J.J. (1988). Axial dispersion in respiratory bronchioles and alveolar ducts. J Appl Physiol (1985), 64(6), 2614-2621.American Physiological Society. doi: 10.1152/jappl.1988.64.6.2614.
  • Gayeski, T.E., Federspiel, W.J., & Honig, C.R. (1988). A graphical analysis of the influence of red cell transit time, carrier-free layer thickness, and intracellular PO2 on blood-tissue O2 transport. Adv Exp Med Biol, 222, 25-35.Springer Nature. doi: 10.1007/978-1-4615-9510-6_3.
  • Federspiel, W., & Fredberg, J.J. (1987). Gas transport in respiratory bronchioles and alveolar ducts. Fed. Proc., 46, (p. 1427).
  • Federspiel, W., & Fredberg, J.J. (1986). Influence of structural complexity on axial dispersion in the acinus. The Physiologist, 29, (p. 94).
  • Federspiel, W.J. (1986). A model study of intracellular oxygen gradients in a myoglobin-containing skeletal muscle fiber. Biophys J, 49(4), 857-868.Elsevier. doi: 10.1016/S0006-3495(86)83715-8.
  • Federspiel, W.J., & Popel, A.S. (1986). A theoretical analysis of the effect of the particulate nature of blood on oxygen release in capillaries. Microvasc Res, 32(2), 164-189.Elsevier. doi: 10.1016/0026-2862(86)90052-x.
  • Clark, A., Federspiel, W.J., Clark, P.A., & Cokelet, G.R. (1985). Oxygen delivery from red cells. Biophys J, 47(2 Pt 1), 171-181.Elsevier. doi: 10.1016/s0006-3495(85)83890-x.
  • CLARK, A., FEDERSPIEL, W.J., CLARK, P.A.A., & COKELET, G.R. (1985). OXYGEN DELIVERY FROM RED-CELLS. BIOPHYSICAL JOURNAL, 47(2), 171-181. doi: 10.1016/S0006-3495(85)83890-X.
  • Federspiel, W., & Popel, A.S. (1984). A theoretical analysis of the effect of the particulate nature of blood on oxygen release in capillaries. Int. J. Microcirc., 3, (p. 407).
  • Federspiel, W.J. (1984). The effect of myoglobin concentration on muscle cell PO2 gradients. Adv Exp Med Biol, 180, 539-543.Springer Nature. doi: 10.1007/978-1-4684-4895-5_51.
  • Federspiel, W.J., & Cokelet, G.R. (1984). BLOOD VISCOELASTICITY FOR CONDITIONS OF PHYSIOLOGICAL FLOW IN SMALL ARTERIES. CHEMICAL ENGINEERING COMMUNICATIONS, 30(3-5), 275-284.Taylor & Francis. doi: 10.1080/00986448408911132.
  • Federspiel, W.J., & Sarelius, I.H. (1984). An examination of the contribution of red cell spacing to the uniformity of oxygen flux at the capillary wall. Microvasc Res, 27(3), 273-285.Elsevier. doi: 10.1016/0026-2862(84)90059-1.
  • Honig, C.R., Gayeski, T.E., Federspiel, W., Clark, A., & Clark, P. (1984). Muscle O2 gradients from hemoglobin to cytochrome: new concepts, new complexities. Adv Exp Med Biol, 169, 23-38.Springer Nature. doi: 10.1007/978-1-4684-1188-1_2.
  • Federspiel, W., & Cokelet, G.R. (1983). Prediction of time dependent blood flow in small glass tubes. Microvasc. Res., 25, (p. 233).
  • Federspiel, W., Clark Jr, A., & Cokelet, G.R. (1982). Oxygen delivery: the view from the red cell. Microvasc. Res., 23, (p. 251).
  • Clark Jr, A., Cokelet, G.R., & Federspiel, W. (1981). Erythrocyte motion and oxygen transport. Biblthca. Anat., 20, 385-388.
  • Madhani, S., May, A., Frankowski, B., Burgreen, G., & Federspiel, W. Blood Recirculation Enhances Oxygenation Efficiency of Artificial Lungs. ASAIO Journal.Lippincott, Williams & Wilkins.

  • Madhani, S.P., May, A.G., Frankowski, B.J., Burgreen, G.W., & Federspiel, W.J. (2020). Blood Recirculation Enhances Oxygenation Efficiency of Artificial Lungs. 44th ESAO and 7th Biennial IFAO Congress.United States. doi: 10.1097/MAT.0000000000001030.
  • Dhamotharan, V., Orizondo, R., & Federspiel, W. (2019). A quantitative approach to detection of increased circuit resistance during ECMO. American Society of Artificial Internal Organs (ASAIO) 65th Annual Conference.San Francisco, CA.
  • Dhamotharan, V., Orizondo, R.A., & Federspiel, W. (2019). A Quantitative Approach to Detection of Increased Circuit Resistance during ECMO. Poster session presented at the meeting of McGowan Institute Scientific Retreat.
  • Federspiel, W., May, A., & Orizondo, R. (2019). 7-day In Vivo Performance of a Low-Flow Extracorporeal CO2 Removal Device. Poster session presented at the meeting of McGowan Institute Scientific Retreat.
  • May, A., Orizondo, R., Frankowski, B.J., Kocyildirim, E., D’Cunha, J., & Federspiel, W. (2019). 7-day In Vivo Performance of a Low-Flow Extracorporeal CO2 Removal Device. American Society of Artificial Internal Organs (ASAIO) 65th Annual Conference.San Francisco.
  • May, A., Orizondo, R.A., Frankowski, B., Wearden, P.D., & Federspiel, W. (2019). Acute In Vivo Performance of a Pediatric Ambulatory Artificial Lung. Poster session presented at the meeting of McGowan Institute Scientific Retreat.
  • Omecinski, K.S., Frankowski, B.J., & Federspiel, W. (2019). Characterization of Floating Impeller Phenomena in an Integrated HFM bundle and Centrifugal Pump Design. Poster session presented at the meeting of McGowan Institute Scientific Retreat.Pittsburgh, PA.
  • Orizondo, R.A., May, A., Frankowski, B.J., Burgreen, G., Ye, S., Kocyildirim, E., Wagner, W., D’Cunha, J., Kormos, R., & Federspiel, W. (2019). Pittsburgh Paracorporeal Ambulatory Assist Lung: Progress Towards a Long-Term Wearable Artificial Lung. American Society of Artificial Internal Organs (ASAIO) 65th Annual Conference.San Francisco.
  • Behrangzade, A., Orizondo, R.A., Kellum, J.A., & Federspiel, W. (2018). Development of a Combined Artificial Lung and Kidney. Poster session presented at the meeting of McGowan Institute Scientific Retreat.Pittsburgh, PA.
  • May, A., Orizondo, R., Frankowski, B.J., Wearden, P.D., & Federspiel, W. (2018). Acute In Vivo Performance of a Pediatric Ambulatory Artificial Lung. 64th Annual American Society for Artificial Internal Organs (ASAIO) Conference.Washington DC.
  • May, A.G., Orizondo, R.A., Frankowski, B.J., Wearden, P.D., & Federspiel, W. (2018). Acute In Vivo Performance of a Pediatric Ambulatory Artificial Lung. Poster session presented at the meeting of McGowan Institute Scientific Retreat.Pittsburgh, PA.
  • Orizondo, R., Madhani, S., May, A., Frankowski, B.J., Ye, S., Kocyildirim, E., Wagner, W., Kormos, R., D’Cunha, J., & Federspiel, W. (2018). Successful 30-day Sheep Studies of a Wearable Pumping Artificial Lung. Poster session presented at the meeting of McGowan Institute Scientific Retreat.Pittsburgh, PA.
  • Orizondo, R., May, A., Frankowski, B.J., Burgreen, G.W., & Federspiel, W. (2018). In Vitro Characterization of a Modular Pump Lung Capable of Multiple Respiratory Assist Applications. Poster session presented at the meeting of McGowan Institute Scientific Retreat.Pittsburgh, PA.
  • Orizondo, R.A., Madhani, S.P., May, A., Frankowski, B.J., Burgreen, G.W., Ye, S., Kocyildirim, E., Wagner, W., Kormos, R.L., D'Cunha, J., & Federspiel, W. (2018). 30 Day Sheep Studies of a Wearable Pumping Artificial Lung. 64th Annual American Society for Artificial Internal Organs (ASAIO) Conference.Washington, DC.
  • Orizondo, R.A., May, A.G., Frankowski, B.J., Burgreen, G.W., & Federspiel, W. (2018). In Vitro Characterization of a Modular Pump Lung Capable of Multiple Respiratory Assist Applications. 64th Annual American Society for Artificial Internal Organs (ASAIO) Conference.Washington, DC.
  • Richards, E., Federspiel, W., Liu, X., Sharma, A.C., Ghosh, R., & Ye, S. (2018). Advancing a System for Generating Universal Blood Plasma. Poster session presented at the meeting of McGowan Institute Scientific Retreat.Pittsburgh, PA.
  • Jeffries, R., Frankowski, B., & Federspiel, W. (2017). High Efficiency Respiratory Dialysis at Ultra-Low Blood Flows. Poster session presented at the meeting of McGowan Institute Scientific Retreat.Farmington, PA.
  • Madhani, S., Ye, S.H., Frankowski, B.J., Burgreen, G.W., Antaki, J.F., May, A., Kormos, R., Wagner, W.R., D’Cunha, J., & Federspiel, W.J. (2017). Chronic In-Vivo Studies of an Integrated Wearable Pump-lung. ASAIO 63rd Annual Conference.Chicago, IL.
  • Madhani, S., Ye, S.H., Frankowski, B.J., Burgreen, G.W., Antaki, J.F., May, A., Kormos, R., Wagner, W.R., D’Cunha, J., & Federspiel, W.J. (2017). Chronic In-Vivo Studies of an Integrated Wearable Pump-lung. ASAIO 63rd Annual Conference.Chicago, IL.
  • Madhani, S.P., Ye, S., Frankowski, B.J., Burgreen, G.W., Antaki, J.W., Kormos, R., Wagner, W.R., D’Cunha, J., & Federspiel, W. (2017). Chronic In-Vivo Studies of an Integrated Wearable Pump-lung. 44th ESAO and 7th Biennial IFAO Congress.Vienna, Austria.
  • Malkin, A., Federspiel, W., Kellum, J., & Singbartl, K. (2017). An Extracorporeal Neutrophil Reprogramming Device for the Treatment of Acute Inflammatory Conditions. Poster session presented at the meeting of McGowan Institute Scientific Retreat.Farmington, PA.
  • May, A.G., Jeffries, R.G., Frankowski, B.J., & Federspiel, W. (2017). Integrated Low Flow Extracorporeal CO2 Removal Device. Poster session presented at the meeting of 44th ESAO and 7th Biennial IFAO Congress.Vienna, Austria.
  • Orizondo, R., May, A., Madhani, S., Frankowski, B., Wearden, P., & Federspiel, W. (2017). Pittsburgh Pediatric Ambulatory Lung (P-PAL). Poster session presented at the meeting of McGowan Institute Scientific Retreat.Farmington, PA.
  • Orizondo, R.A., Gino, G., Sultzbach, G., Madhani, S.P., Frankowski, B.J., & Federspiel, W. (2017). Effects of Hollow Fiber Oscillation on Artificial Lungs. Poster session presented at the meeting of ASAIO 63rd Annual Conference.Chicago, IL.
  • Orizondo, R.A., Gino, G., Sultzbach, G., Madhani, S.P., Frankowski, B.J., & Federspiel, W. (2017). Effects of Hollow Fiber Oscillation on Artificial Lungs. Poster session presented at the meeting of 44th ESAO and 7th Biennial IFAO Congress.Vienna, Austria.
  • Orizondo, R.A., May, A., Madhani, S.P., Frankowski, B.J., Burgreen, G.W., Wearden, P.D., & Federspiel, W. (2017). In vitro Characterization and In vivo Performance of the Pittsburgh Pediatric Ambulatory Lung Device. 13th International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion.Rome, Italy.
  • Orizondo, R.A., May, A.G., Madhani, S.P., Frankowski, B.J., Burgreen, G.W., Wearden, P.D., & Federspiel, W. (2017). In Vitro Characterization of the Pittsburgh Pediatric Ambulatory Lung (P-PAL). 44th ESAO and 7th Biennial IFAO Congress.Vienna, Austria.
  • Kimmel, J.D., Arazawa, D., & Federspiel, W. (2012). Bioactive Hollow Fiber Membranes Coated with Chitosan and Carbonic Anhydrase for Artificial Lung Applications. Poster session presented at the meeting of University of Pittsburgh Postdoctoral Association 2012 Postdoctoral Data & Dine Symposium.Pittsburgh, PA.
  • Vodovotz, Y., Valenti, I., Peng, Z., Namas, R., Mi, Q., Kellum, J., Federspiel, W., DiLeo, M., & Barclay, D. (2011). Effects of Hemoadsorption of inflammation in e.coli induced fibrin peritonitis. Society of Critical Care Medicine Annual Meeting.
  • DiLeo, M.V., & Federspiel, W. (2010). Selective improvement of TNF capture in a cytokine hemoadsorption device using immobilized anti-TNF. Poster session presented at the meeting of University of Pittsburgh Safar Conference.Pittsburgh, PA.
  • Kimmel, J., Lacko, C., Kellum, J., & Federspiel, W. (2010). TNF Capture Dynamics within Hemoadsorption Beads Used to Treat Sepsis. Poster session presented at the meeting of University of Pittsburgh Safar Conference.Pittsburgh, PA.
  • Kimmel, J.D., Gibson, G.A., Watkins, S.C., & Federspiel, W. (2009). Dynamics of cytokine capture within hemoadsorption beads used to treat sepsis. BMES Conference.Pittsburgh, PA.
  • Rothstein, S.N., Federspiel, W., & Little, S. (2008). Towards the Rational Design of Controlled Release Therapeutics. AIChE 2008 Annual Meeting.Philadelphia, PA.
  • Rothstein, S.N., Federspiel, W., & Little, S. (2008). Towards the Rational Design of Biodegradable Controlled Release Vehicles. AIChE 2008 Annual Meeting.Philadelphia, PA.
  • Rothstein, S.N., Federspiel, W., & Little, S. (2008). A unified mathematical model for predicting controlled release from surface and bulk eroding matrices without regression. Poster session presented at the meeting of AIChE 2008 Annual Meeting.Philadelphia, PA.
  • Rothstein, S.N., Federspiel, W., & Little, S. (2008). Towards the Rational Design of Controlled Release Therapeutics. Biotechnology and Bioengineering Research Symposium. Biomedical Engineering Graduate Society Symposium, Carnegie Mellon University.Pittsburgh, PA.
  • Oh, H.I., Solovan, J.C., Alikhani, A.H., & Federspiel, W. (2005). Design of Specific Antibody Filters to Facilitate ABO-Blood Incompatible Transplantation. Poster session presented at the meeting of McGowan Institute Scientific Retreat.Farmington, PA.
  • Ghadiali, S.N., Swarts, J.D., Federspiel, W., Banks, J., Karnavas, W., & Doyle, W.J. (2001). Demonstration of eustachian tube compliance using a modified forced response system. Association for Research in Otolaryngology Mid-winter Meeting.St. Petersburg, FL.
  • Federspiel, W. (1990). Fluid Mechanics in Alveolar Ducts. Annual Fall Meeting of the Biomedical Engineering Society.Blacksburg, VA.

  • Federspiel, W., Kellum, J., & Singbartl, K. (2019). Devices, Systems And Methods For Cell Modification. 10,258,734.
  • Federspiel, W., Frankowski, B., Antaki, J., Bermudez, C., Jeffries, R., Wagner, W., & Ye, S. (2018). Extracorporeal ambulatory assist lung. 10,080,834.
  • Jeffries, R., Federspiel, W., & Frankowski, B. (2018). Extracorporeal Gas Exchange Devices, Systems and Methods.
  • Madhani, S., Frankowski, B., Federspiel, W., Burgreen, G., & Antaki, J. (2018). Extracorporeal Ambulatory Assist Lung.
  • Madhani, S.P., Frankowski, B.J., Federspiel, W., Burgreen, G., & Antaki, J.F. (2018). Extracorporeal Ambulatory Assist Lung.
  • Federspiel, W., Arazawa, D., & Kimmel, J. (2017). Devices, Systems And Methods For Reducing The Concentration Of Carbon Dioxide In Blood. 9,814,821.
  • Federspiel, W., Kellum, J., & Singbartl, K. (2017). Devices, Systems And Methods For Cell Modification.
  • Federspiel, W., Kellum, J., & Singbartl, K. (2017). Devices, Systems And Methods For Cell Modification.
  • Madhani, S., Frankowski, B., & Federspiel, W. (2017). Lung Assist Device With Oscillating Fiber Bundle. 15/288,111.
  • Federspiel, W., Frankowski, B., Yoshida, T., & Vernucci, P. (2016). Oxygen depletion devices and methods for removing oxygen from red blood cells. 9,296,990.
  • Madhani, S., Frankowski, B., & Federspiel, W. (2016). Lung Assist Device with Oscillating Fiber Bundle.
  • Madhani, S.P., Frankowski, B.J., & Federspiel, W. (2016). Extracorporeal Ambulator Assist Lung.
  • Federspiel, W., Arazawa, D.T., & Kimmel, J.D. (2015). Devices, Systems And Methods For Reducing The Concentration Of Carbon Dioxide In Blood. 14/405038.
  • Federspiel, W., Frankowski, B.J., Antaki, J.F., Bermudez, C., Jeffries, R.G., & Wagner, W.R. (2015). Extracorporeal Ambulator Assist Lung. 14/647,861.
  • Federspiel, W., Frankowski, B.J., Antaki, J.F., Bermudez, C., Jeffries, R.G., & Wagner, W.R. (2015). Extracorporeal Ambulator Assist Lung.
  • Jeffries, R.G., Federspiel, W., & Frankowski, B.J. (2015). Extracorporeal Gas Exchange Devices, Systems and Methods.
  • Jeffries, R.G., Federspiel, W., & Frankowski, B.J. (2015). Extracorporeal Gas Exchange Devices, Systems And Methods.
  • Kellum, J.A., & Federspiel, W. (2015). Removal of Carbon Dioxide via Dialysis. 14/761,321.
  • Madhani, S.P., Frankowksi, B.J., & Federspiel, W. (2015). Lung Assist Device with Oscillating Fiber Bundle.
  • Federspiel WJ, Frankowski BJ, Mack BC, Morley SW, Rosenberg M, & Svitek RG. (2014). Paracorporeal Respiratory Assist Lung. 13/084100.
  • Federspiel, W., Frankowski, B.J., Mack, B.C., Morley, S.W., Rosenberg, M., & Svitek, R.G. (2014). Paracorporeal Respiratory Assist Lung. 8,647,569.
  • Frankowski BJ, Federspiel WJ, Mihelc KM, & Lieber SC. (2014). Intracorporeal Gas Exchange Devices, Systems and Methods. 8,734,382.
  • Frankowski, B.J., Federspiel, W., Mihelc, K.M., & Lieber, S.C. (2014). Intracorporeal Gas Exchange Devices, Systems and Methods. 8,734,382.
  • Kellum, J.A., Federspiel, W., & Cove, M. (2014). Removal of Carbon Dioxide Via Dialysis. PCT/US2014/012151.
  • Federspiel WJ, Frankowski BJ, Yoshida T, & Vernucci PJ. (2013). Oxygen depletion devices and methods for removing oxygen from red blood cells. 14/038,001.
  • Federspiel WJ, Frankowski BJ, Yoshida T, & Vernucci PJ. (2013). Oxygen depletion devices and methods for removing oxygen from red blood cells. 8,569,052.
  • Federspiel, W., Arazawa, D.T., & Kimmel, J.D. (2013). Devices, Systems And Methods For Reducing The Concentration Of Carbon Dioxide In Blood. PCT/US2013/046042.
  • Federspiel, W., Frankowski, B.J., Antaki, J., Bermudez, C., Jeffries, R.G., & Wagner, W.R. (2013). Extracorporeal Ambulator Assist Lung.
  • Kellum, J.A., Federspiel, W., & Cove, M.E. (2013). Removal of Carbon Dioxide Via Dialysis. 61/754,435.
  • Federspiel WJ, Kellum JA, & Singbartl K. (2012). Devices Systems and Methods for Cell Modification. PCT/US2010/051772.
  • Federspiel WJ, Yoshida T, Vernucci PJ, Frankowski BJ, & Wheeler Lund L. (2012). Removal Of Oxygen From Biological Fluids. 13/387,528.
  • Federspiel, W., Arazawa, D.T., & Kimmel, J.D. (2012). Devices, Systems And Methods For Reducing The Concentration Of Carbon Dioxide In Blood. 61/660,013.
  • Federspiel, W., Russell, A.J., Oh, H., & Kaar, J. (2012). Devices, systems and methods for reducing the concentration of a chemical entity in fluids. 8,323,379.
  • Federspiel WJ, Frankowski BJ, Yoshida T, & Vernucci PJ. (2011). Oxygen depletion devices and methods for removing oxygen from red blood cells. 13/115,532.
  • Federspiel, W., Frankowski, B.J., Mack, B.C., Morley, S.W., Rosenberg, M., & Svitek, R.G. (2011). Paracorporeal Respiratory Assist Lung. 7,927,544.
  • Federspiel, W., Frankowski, B.J., Mack, B.C., Morley, S.W., Rosenberg, M., & Svitek, R.G. (2011). Paracorporeal Respiratory Assist Lung. 13/084100.
  • Federspiel, W., Russell, A.J., Oh, H., & Kaar, J. (2011). Devices, systems and methods for reducing the concentration of a chemical entity in fluids. 13/280,033.
  • Federspiel, W., Russell, A.J., Oh, H., & Kaar, J. (2011). Devices, Systems and Methods for Reducing the Concentration of a Chemical Entity in Fluids. 8,043,411.
  • Federspiel WJ, Kellum JA, & Singbartl K. (2010). Devices Systems and Methods for Cell Modification. 13/500,163.
  • Federspiel WJ, Yoshida T, Vernucci PJ, Frankowski BJ, & Wheeler Lund L. (2010). Removal of Oxygen from Biological Fluids. 61/230,575.
  • Federspiel WJ, Yoshida T, Vernucci PJ, Frankowski BJ, & Wheeler Lund L. (2010). Removal of Oxygen from Biological Fluids. PCT/US2010/44045.
  • Federspiel, W., Russell, A.J., Oh, H., & Kaar, J. (2010). Devices, Systems and Methods for Reducing the Concentration of a Chemical Entity in Fluids. 12/816,455.
  • Federspiel, W., Russell, A.J., Oh, H., & Kaar, J. (2010). Devices, Systems and Methods for Reducing the Concentration of a Chemical Entity in Fluids. 7,763,097.
  • Frankowski BJ, Federspiel WJ, Mihelc KM, & Lieber SC. (2009). Intracorporeal Gas Exchange Devices, Systems and Methods. PCT/US2009/033399.
  • Frankowski BJ, Federspiel WJ, Mihelc KM, & Lieber SC. (2009). Intracorporeal Gas Exchange Devices, Systems and Methods. 12/865,958.
  • Federspiel, W., Russell, A.J., Oh, H., & Kaar, J. (2007). Devices, Systems and Methods for Reducing the Concentration of a Chemical Entity in Fluids. 11,811,265.
  • Federspiel, W., Russell, A.J., Oh, H., & Kaar, J. (2007). Devices, Systems and Methods for Reducing the Concentration of a Chemical Entity in Fluids. PCT/US2007/013563.
  • Federspiel, W., Frankowski, B.J., Mack, B.C., Morley, S.W., Rosenberg, M., & Svitek, R.G. (2006). Paracorporeal Respiratory Assist Lung. 11/408,650.
  • Federspiel, W., Frankowski, B.J., Mack, B.C., Morley, S.W., Rosenberg, M., & Svitek, R.G. (2006). Paracorporeal Respiratory Assist Lung. PCT/US06/15000.
  • Hattler BG, Federspiel WJ, & Frankowski BJ. (2006). Percutaneous Respiratory Assist Catheter Incorporating A Spinning Fiber Bundle. 60/688,861.
  • Hattler BG, Federspiel WJ, & Frankowski BJ. (2006). Percutaneous Respiratory Assist Catheter Incorporating A Spinning Fiber Bundle. PCT/US06/15002.
  • Frankowski BJ, Federspiel WJ, Golob Jr. JF, & Hattler BG. (2003). Magnetic Guidewires. 10/434,555.
Research Interests
Biomedical engineering Clinical sciences Chemical engineering Materials engineering Cardiovascular medicine and haematology Fluid mechanics and thermal engineering