The TMJ labs are part of the Center for Craniofacial Regeneration (CCR). The CCR is based at the University of Pittsburgh School of Dental Medicine and the McGowan Institute for Regenerative Medicine, a program of the University of Pittsburgh and the University of Pittsburgh Medical Center The Center for Craniofacial Regeneration is comprised of a diverse team of clinicians, basic scientists, and clinical researchers.
PROJECTS
TMD Rat Model
In collaboration with the Gold lab, we are testing a TMD rat model to establish the relationship between chronic pain and TMJ degeneration. Currently, TMD is being induced using bite-raising splints, and multiple versions of this method are being tested for the best results.
Extracellular Matrix TMJ Disc Device
In collaboration with the Badylak lab, we are currently testing the in vivo regeneration potential of TMJ disc scaffolds derived from porcine urinary bladder matrix in a canine model. In a pilot study, after six months, the morphology of the remodeled UBM scaffold resembles that of the native TMJ disc.
Pain, Kinematics, and Mechanical Properties
We are using a splint-induced malocclusion model of TMD pain where we combine information from dual x-ray and μ-CT to assess 3D Bone Positions. In the process, we propose to validate a non-invasive technique for imaging TMJ arthrokinematics as a means of assessing the development of joint hypersensitivity.
Polymer Bone Scaffold
We are investigating the application of the elastomeric material Poly(glycerol Sebacate) (PGS) for bone engineering. The material superiority regards its load-transduction to osteogenic cells, steady biodegradability and the ability of application in non-uniformly loaded defects such as craniofacial osteo/chondro defects.
Contact Information
TMJ Laboratories
409 Salk Pavilion
3501 Terrace Street
Pittsburgh, PA 15261
Phone: (412) 648-3101
Fax: (412) 624-6685