headshot

Carla Ng

Assistant Professor
Group Website @Ng_lab Civil & Environmental Engr

overview

Dr. Carla Ng (Baumel) works at the intersection of chemistry, biology and engineering to develop models for the fate of chemicals in organisms and ecosystems. Her research interests span multiple scales, from molecules to global systems. Active research areas in her group include: - development of integrative modeling strategies to understand the biological fate and effects of per- and polyfluoroalkyl substances (PFAS) - the role of the global industrial food system on the transport and fate of environmental contaminants and subsequent human exposure. - developing quantitative models for structure-based chemicals assessment, including the emergence and importance of chemical transformation products in complex mixtures. - harnessing biology to design innovative approaches to treat emerging contaminants. - advancing systems-level understanding of the cascading ecological and water quality benefits of green infrastructure - understanding the fundamental mechanisms that determine whether an industrial pollutant will be bioavailable and bioaccumulative

about

(2019 - 2024) NSF CAREER Award.

NSF Graduate Research Fellowship.

BS, Chemical Engineering, State University of New York at Buffalo, 2001

MS, Chemical Engineering, State University of New York at Buffalo, 2003

PhD, Chemical and Biological Engineering, Northwestern University, 2008

Birru, R.L., Liang, H.W., Farooq, F., Bedi, M., Feghali, M., Haggerty, C.L., Mendez, D.D., Catov, J.M., Ng, C.A., & Adibi, J.J. (2021). A pathway level analysis of PFAS exposure and risk of gestational diabetes mellitus. ENVIRONMENTAL HEALTH, 20(1), 63.Springer Science and Business Media LLC. doi: 10.1186/s12940-021-00740-z.

Cao, Y., & Ng, C. (2021). Absorption, distribution, and toxicity of per- and polyfluoroalkyl substances (PFAS) in the brain: a review. Environ Sci Process Impacts.Royal Society of Chemistry (RSC). doi: 10.1039/d1em00228g.

Cheng, W., Doering, J.A., LaLone, C., & Ng, C. (2021). Integrative Computational Approaches to Inform Relative Bioaccumulation Potential of Per- and Polyfluoroalkyl Substances Across Species. TOXICOLOGICAL SCIENCES, 180(2), 212-223.Oxford University Press (OUP). doi: 10.1093/toxsci/kfab004.

Cousins, I.T., De Witt, J.C., Gluge, J., Goldenman, G., Herzke, D., Lohmann, R., Miller, M., Ng, C.A., Patton, S., Scheringer, M., Trier, X., & Wang, Z. (2021). Finding essentiality feasible: common questions and misinterpretations concerning the "essential-use" concept. ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS, 23(8), 1079-1087.Royal Society of Chemistry (RSC). doi: 10.1039/d1em00180a.

De Silva, A.O., Armitage, J.M., Bruton, T.A., Dassuncao, C., Heiger-Bernays, W., Hu, X.C., Karrman, A., Kelly, B., Ng, C., Robuck, A., Sun, M., Webster, T.F., & Sunderland, E.M. (2021). PFAS Exposure Pathways for Humans and Wildlife: A Synthesis of Current Knowledge and Key Gaps in Understanding. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 40(3), 631-657.Wiley. doi: 10.1002/etc.4935.

Fenton, S.E., Ducatman, A., Boobis, A., DeWitt, J.C., Lau, C., Ng, C., Smith, J.S., & Roberts, S.M. (2021). Per- and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 40(3), 606-630.Wiley. doi: 10.1002/etc.4890.

Glüge, J., London, R., Cousins, I.T., DeWitt, J., Goldenman, G., Herzke, D., Lohmann, R., Miller, M., Ng, C.A., Patton, S., Trier, X., Wang, Z., & Scheringer, M. (2021). Information Requirements under the Essential-Use Concept: PFAS Case Studies. Environ Sci Technol.American Chemical Society (ACS). doi: 10.1021/acs.est.1c03732.

Han, J., Fu, J., Sun, J., Hall, D.R., Yang, D., Blatz, D., Houck, K., Ng, C., Doering, J., LaLone, C., & Peng, H. (2021). Quantitative Chemical Proteomics Reveals Interspecies Variations on Binding Schemes of L-FABP with Perfluorooctanesulfonate. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 55(13), 9012-9023.American Chemical Society (ACS). doi: 10.1021/acs.est.1c00509.

Khazaee, M., Christie, E., Cheng, W., Michalsen, M., Field, J., & Ng, C. (2021). Perfluoroalkyl Acid Binding with Peroxisome Proliferator-Activated Receptors alpha, gamma, and delta, and Fatty Acid Binding Proteins by Equilibrium Dialysis with a Comparison of Methods. TOXICS, 9(3), 45.MDPI AG. doi: 10.3390/toxics9030045.

Ng, C., Cousins, I.T., DeWitt, J.C., Glüge, J., Goldenman, G., Herzke, D., Lohmann, R., Miller, M., Patton, S., Scheringer, M., Trier, X., & Wang, Z. (2021). Addressing Urgent Questions for PFAS in the 21st Century. Environ Sci Technol, 55(19), 12755-12765.American Chemical Society (ACS). doi: 10.1021/acs.est.1c03386.

Bedi, M., von Goetz, N., & Ng, C. (2020). Estimating polybrominated diphenyl ether (PBDE) exposure through seafood consumption in Switzerland using international food trade data. ENVIRONMENT INTERNATIONAL, 138, 105652.Elsevier BV. doi: 10.1016/j.envint.2020.105652.

Cousins, I.T., DeWitt, J.C., Gluege, J., Goldenman, G., Herzke, D., Lohmann, R., Ng, C.A., Scheringer, M., & Wang, Z. (2020). The high persistence of PFAS is sufficient for their management as a chemical class. ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS, 22(12), 2307-2312.Royal Society of Chemistry (RSC). doi: 10.1039/d0em00355g.

Cousins, I.T., DeWitt, J.C., Gluge, J., Goldenman, G., Herzke, D., Lohmann, R., Miller, M., Ng, C.A., Scheringer, M., Vierke, L., & Wang, Z. (2020). Strategies for grouping per- and polyfluoroalkyl substances (PFAS) to protect human and environmental health. ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS, 22(7), 1444-1460.Royal Society of Chemistry (RSC). doi: 10.1039/d0em00147c.

Gluege, J., Scheringer, M., Cousins, I.T., DeWitt, J.C., Goldenman, G., Herzke, D., Lohmann, R., Ng, C.A., Trier, X., & Wang, Z. (2020). An overview of the uses of per- and polyfluoroalkyl substances (PFAS). ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS, 22(12), 2345-2373.Royal Society of Chemistry (RSC). doi: 10.1039/d0em00291g.

Khazaee, M., Guardian, M.G.E., Aga, D.S., & Ng, C.A. (2020). Impacts of Sex and Exposure Duration on Gene Expression in Zebrafish Following Perfluorooctane Sulfonate Exposure. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 39(2), 437-449.Wiley. doi: 10.1002/etc.4628.

Lohmann, R., Cousins, I.T., DeWitt, J.C., Gluege, J., Goldenman, G., Herzke, D., Lindstrom, A.B., Miller, M.F., Ng, C.A., Patton, S., Scheringer, M., Trier, X., & Wang, Z. (2020). Are Fluoropolymers Really of Low Concern for Human and Environmental Health and Separate from Other PFAS?. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 54(20), 12820-12828.American Chemical Society (ACS). doi: 10.1021/acs.est.0c03244.

Sleight, T.W., Khanna, V., Gilbertson, L.M., & Ng, C.A. (2020). Network Analysis for Prioritizing Biodegradation Metabolites of Polycyclic Aromatic Hydrocarbons. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 54(17), 10725-10734.American Chemical Society (ACS). doi: 10.1021/acs.est.0c02217.

Yang, D., Han, J., Hall, D.R., Sun, J., Fu, J., Kutarna, S., Houck, K.A., LaLone, C.A., Doering, J.A., Ng, C.A., & Peng, H. (2020). Nontarget Screening of Per- and Polyfluoroalkyl Substances Binding to Human Liver Fatty Acid Binding Protein. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 54(9), 5676-5686.American Chemical Society (ACS). doi: 10.1021/acs.est.0c00049.

Cheng, W., & Ng, C.A. (2019). Using Machine Learning to Classify Bioactivity for 3486 Per- and Polyfluoroalkyl Substances (PFASs) from the OECD List. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 53(23), 13970-13980.American Chemical Society (ACS). doi: 10.1021/acs.est.9b04833.

Cousins, I.T., Goldenman, G., Herzke, D., Lohmann, R., Miller, M., Ng, C.A., Patton, S., Scheringer, M., Trier, X., Vierke, L., Wang, Z., & DeWitt, J.C. (2019). The concept of essential use for determining when uses of PFASs can be phased out. ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS, 21(11), 1803-1815.Royal Society of Chemistry (RSC). doi: 10.1039/c9em00163h.

Cousins, I.T., Ng, C.A., Wang, Z., & Scheringer, M. (2019). Why is high persistence alone a major cause of concern? (vol 21, pg 781, 2019). ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS, 21(5), 904.Royal Society of Chemistry (RSC). doi: 10.1039/c9em90019e.

Cousins, I.T., Ng, C.A., Wang, Z., & Scheringer, M. (2019). Why is high persistence alone a major cause of concern?. ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS, 21(5), 781-792.Royal Society of Chemistry (RSC). doi: 10.1039/c8em00515j.

Cheng, W., & Ng, C.A. (2018). Predicting Relative Protein Affinity of Novel Per- and Polyfluoroalkyl Substances (PFASs) by An Efficient Molecular Dynamics Approach. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 52(14), 7972-7980.American Chemical Society (ACS). doi: 10.1021/acs.est.8b01268.

Khazaee, M., & Ng, C.A. (2018). Evaluating parameter availability for physiologically based pharmacokinetic (PBPK) modeling of perfluorooctanoic acid (PFOA) in zebrafish. ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS, 20(1), 105-119.Royal Society of Chemistry (RSC). doi: 10.1039/c7em00474e.

Mendez, A., Castillo, L.E., Ruepert, C., Hungerbuehler, K., & Ng, C.A. (2018). Tracking pesticide fate in conventional banana cultivation in Costa Rica: A disconnect between protecting ecosystems and consumer health. SCIENCE OF THE TOTAL ENVIRONMENT, 613, 1250-1262.Elsevier BV. doi: 10.1016/j.scitotenv.2017.09.172.

Mittal, V.K., & Ng, C.A. (2018). Formation of PFAAs in fish through biotransformation: A PBPK approach. CHEMOSPHERE, 202, 218-227.Elsevier BV. doi: 10.1016/j.chemosphere.2018.03.064.

Ng, C.A., Ritscher, A., Hungerbuehler, K., & von Goetz, N. (2018). Polybrominated Diphenyl Ether (PBDE) Accumulation in Farmed Salmon Evaluated Using a Dynamic Sea-Cage Production Model. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 52(12), 6965-6973.American Chemical Society (ACS). doi: 10.1021/acs.est.8b00146.

Sun, X., Ng, C.A., & Small, M.J. (2018). Modeling the impact of biota on polychlorinated biphenyls (PCBs) fate and transport in Lake Ontario using a population-based multi compartment fugacity approach. ENVIRONMENTAL POLLUTION, 241, 720-729.Elsevier BV. doi: 10.1016/j.envpol.2018.05.068.

Sun, X., Ng, C.A., & Small, M.J. (2018). A population-based simultaneous fugacity model design for polychlorinated biphenyls (PCBs) transport in an aquatic system. MethodsX, 5, 1311-1323.Elsevier BV. doi: 10.1016/j.mex.2018.07.001.

Armitage, J.M., Erickson, R.J., Luckenbach, T., Ng, C.A., Prosser, R.S., Arnot, J.A., Schirmer, K., & Nichols, J.W. (2017). ASSESSING THE BIOACCUMULATION POTENTIAL OF IONIZABLE ORGANIC COMPOUNDS: CURRENT KNOWLEDGE AND RESEARCH PRIORITIES. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 36(4), 882-897.Wiley. doi: 10.1002/etc.3680.

Cheng, W., & Ng, C.A. (2017). A Permeability-Limited Physiologically Based Pharmacokinetic (PBPK) Model for Perfluorooctanoic acid (PFOA) in Male Rats. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 51(17), 9930-9939.American Chemical Society (ACS). doi: 10.1021/acs.est.7b02602.

Ng, C.A., & von Goetz, N. (2017). The Global Food System as a Transport Pathway for Hazardous Chemicals: The Missing Link between Emissions and Exposure. ENVIRONMENTAL HEALTH PERSPECTIVES, 125(1), 1-7.Environmental Health Perspectives. doi: 10.1289/EHP168.

Gilbertson, L.M., & Ng, C.A. (2016). Evaluating the Use of Alternatives Assessment To Compare Bulk Organic Chemical and Nanomaterial Alternatives to Brominated Flame Retardants. ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 4(11), 6019-6030.American Chemical Society (ACS). doi: 10.1021/acssuschemeng.6b01318.

Mendez, A., Ng, C.A., Machado Torres, J.P., Bastos, W., Bogdal, C., dos Reis, G.A., & Hungerbuehler, K. (2016). Modeling the dynamics of DDT in a remote tropical floodplain: indications of post-ban use?. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 23(11), 10317-10334.Springer Science and Business Media LLC. doi: 10.1007/s11356-015-5641-x.

Ng, C.A., & Hungerbuehler, K. (2015). Exploring the Use of Molecular Docking to Identify Bioaccumulative Perfluorinated Alkyl Acids (PFAAs). ENVIRONMENTAL SCIENCE & TECHNOLOGY, 49(20), 12306-12314.American Chemical Society (ACS). doi: 10.1021/acs.est.5b03000.

Gabbert, S., Scheringer, M., Ng, C.A., & Stolzenberg, H.C. (2014). Socio-economic analysis for the authorisation of chemicals under REACH: A case of very high concern?. REGULATORY TOXICOLOGY AND PHARMACOLOGY, 70(2), 564-571.Elsevier BV. doi: 10.1016/j.yrtph.2014.08.013.

Ng, C.A., & Hungerbuehler, K. (2014). Bioaccumulation of Perfluorinated Alkyl Acids: Observations and Models. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 48(9), 4637-4648.American Chemical Society (ACS). doi: 10.1021/es404008g.

Stieger, G., Scheringer, M., Ng, C.A., & Hungerbuehler, K. (2014). Assessing the persistence, bioaccumulation potential and toxicity of brominated flame retardants: Data availability and quality for 36 alternative brominated flame retardants. CHEMOSPHERE, 116, 118-123.Elsevier BV. doi: 10.1016/j.chemosphere.2014.01.083.

Gouin, T., Armitage, J.M., Cousins, I.T., Muir, D.C.G., Ng, C.A., Reid, L., & Tao, S. (2013). Influence of global climate change on chemical fate and bioaccumulation: The role of multimedia models. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 32(1), 20-31.Wiley. doi: 10.1002/etc.2044.

Ng, C.A., & Hungerbuehler, K. (2013). Bioconcentration of Perfluorinated Alkyl Acids: How Important Is Specific Binding?. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 47(13), 7214-7223.American Chemical Society (ACS). doi: 10.1021/es400981a.

Scheringer, M., Strempel, S., Ng, C.A., & Hungerbuehler, K. (2013). Response to Comment on Screening for PBT Chemicals among the "Existing" and "New" Chemicals of the EU. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 47(11), 6065-6066.American Chemical Society (ACS). doi: 10.1021/es401769z.

Camenzuli, L., Scheringer, M., Gaus, C., Ng, C.A., & Hungerbuehler, K. (2012). Describing the environmental fate of diuron in a tropical river catchment. SCIENCE OF THE TOTAL ENVIRONMENT, 440, 178-185.Elsevier BV. doi: 10.1016/j.scitotenv.2012.07.037.

Scheringer, M., Strempel, S., Hukari, S., Ng, C.A., Blepp, M., & Hungerbuhler, K. (2012). How many persistent organic pollutants should we expect?. ATMOSPHERIC POLLUTION RESEARCH, 3(4), 383-391.Elsevier BV. doi: 10.5094/APR.2012.044.

Strempel, S., Scheringer, M., Ng, C.A., & Hungerbuehler, K. (2012). Screening for PBT Chemicals among the "Existing" and "New" Chemicals of the EU. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 46(11), 5680-5687.American Chemical Society (ACS). doi: 10.1021/es3002713.

Ng, C.A., & Gray, K.A. (2011). Forecasting the effects of global change scenarios on bioaccumulation patterns in great lakes species. GLOBAL CHANGE BIOLOGY, 17(2), 720-733.Wiley. doi: 10.1111/j.1365-2486.2010.02299.x.

Ng, C.A., Scheringer, M., Fenner, K., & Hungerbuhler, K. (2011). A Framework for Evaluating the Contribution of Transformation Products to Chemical Persistence in the Environment. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 45(1), 111-117.American Chemical Society (ACS). doi: 10.1021/es1010237.

Ng, C.A., & Gray, K.A. (2009). Tracking bioaccumulation in aquatic organisms: A dynamic model integrating life history characteristics and environmental change. ECOLOGICAL MODELLING, 220(9-10), 1266-1273.Elsevier BV. doi: 10.1016/j.ecolmodel.2009.02.007.

Ng, C.A., Berg, M.B., Jude, D.J., Janssen, J., Charlebois, P.M., Amaral, L.A.N., & Gray, K.A. (2008). Chemical amplification in an invaded food web: Seasonality and ontogeny in a high-biomass, low-diversity ecosystem. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 27(10), 2186-2195.Wiley. doi: 10.1897/07-636.1.

Stouffer, D.B., Ng, C.A., & Amaral, L.A.N. (2008). Ecological Engineering and Sustainabitity: A New Opportunity for Chemical Engineering. AICHE JOURNAL, 54(12), 3040-3047.Wiley. doi: 10.1002/aic.11720.

Stouffer, D.B., Camacho, J., Guimera, R., Ng, C.A., & Amaral, L.A.N. (2005). Quantitative patterns in the structure of model and empirical food webs. ECOLOGY, 86(5), 1301-1311.Wiley. doi: 10.1890/04-0957.

Dong, Z., Bain, D., Akcakaya, M., & Ng, C. Evaluating a Sewershed Urban Storm Water Model for Variability in Parameter Sensitivity and Resolution Effects. Center for Open Science. doi: 10.31224/osf.io/u5tsz.

Glüge, J., Scheringer, M., Cousins, I., DeWitt, J.C., Goldenman, G., Herzke, D., Lohmann, R., Ng, C., Trier, X., & Wang, Z. An overview of the uses of per- and polyfluoroalkyl substances (PFAS). Center for Open Science. doi: 10.31224/osf.io/2eqac.

Cheng, W., Khazaee, M., & Ng, C. (2019). Beyond legacy PFAS: Models to inform assessment across structural classes and species. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 257.

Khazaee, M., Christie, E., Michalsen, M., Field, J., & Ng, C. (2019). PFAS binding affinity with liver fatty acid binding protein, intestinal fatty acid binding protein, and peroxisome proliferator-activated receptors alpha, delta, and gamma. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 258.

Ng, C.A., & Gray, K.A. (2006). Predicting bioaccumulation in dynamic food webs: Ontogeny, seasonality and invasional successions. In AIChE Annual Meeting, Conference Proceedings.

Amaral, L.A.N., Ng, C., & Gray, K. (2005). Seasonal and ontogenetic diet changes in aquatic food webs result in surprising bioaccumulation patterns. In AIChE Annual Meeting, Conference Proceedings, (p. 10714).

Ishida, C.K., Gray, K., & Ng, C.A. (2004). Cultivating periphyton to accelerate rates of denitrification in wetlands. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 228, (pp. U623-U624).

Ng, C.A., Gray, K.A., Berg, M.B., & Amaral, L.A.N. (2004). Network-centered modeling of bioaccumulation in freshwater food webs. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 228, (p. U624).

Research interests

bioaccumulation
Ecosystem Modeling
exposure modeling
green chemistry
risk assessment
sustainability
toxicokinetics