headshot of Walter Storkus

Walter Storkus

Professor
Assistant Professor
Bioengineering Department

overview

Over the past 30 years my laboratory has studied tumor immunobiology and designed immunotherapies for the treatment of cancer based on results gained in the laboratory. My near-term research goal remains the development of novel phase I/II clinical trials for the treatment of patients with cancer, with a focus on melanoma and RCC. Such treatment modalities have included dendritic cell (DC)-based vaccines, cytokine gene-modified DC injected directly into tumor lesions and combination treatment approaches integrating agents that modulate tumor cell immune recognition or alter the balance or Type-1 versus regulatory immunity in the tumor microenvironment (TME). We have discovered that immune targeting of the tumor-associated vasculature occurs naturally during effective immunotherapy, and that vaccines targeting tumor blood vessel antigens (TBVA) can promote tumor regression, even in cases where cancer cells themselves cannot be directly recognized by protective/therapeutic CD8+ T cells. We have also determined that treatment with anti-angiogenic agents leads to tumor vascular normalization and to the improved chemokine-dependent recruitment of therapeutic T cells into the TME leading to formation of tertiary lymphoid structures (TLS) in association with slowed tumor growth and extended survival in animal models. We recently completed a pilot phase II clinical trial (UPCI 12-048/NCT01876212) evaluating combined treatment of HLA-A2+ patients with autologous DC1/TBVA peptide vaccines + dasatinib where we observed objective clinical responses in 46% of evaluable patients with advanced-stage cutaneous or uveal melanoma, including 57% of patients with prior demonstration of primary resistance to anti-PD1-based immunotherapy. Novel DC/TBVA peptide vaccines are currently being investigated in pilot phase II studies supported by NIH R01 (NCT05127824) and P01 (NCT04093323) in the setting of checkpoint-refractory advanced melanoma and early-stage renal cell carcinoma. We are currently investigating the use of IRF3 agonists (including STING agonists) delivered directly into the TME as components of in situ vaccines in the advanced disease setting with the intent to promote formation of TLS in situ for improved local cross-priming of novel therapeutic anti-tumor B cell and T cell repertoires.

about

PhD, Duke University School of Medicine, 1982 - 1986

BA, Brandeis University, 1977 - 1981

Filderman, J.N., Luke, J.J., & Storkus, W.J. (2023). Platelet STING agonism and venous thrombosis: translational implications for improved disease outcomes. JOURNAL OF LEUKOCYTE BIOLOGY, 114(3), 195-198.Oxford University Press (OUP). doi: 10.1093/jleuko/qiad073.

Karapetyan, L., AbuShukair, H.M., Li, A., Knight, A., Al Bzour, A.N., MacFawn, I.P., Thompson, Z.J., Chen, A., Yang, X., Dadey, R., Karunamurthy, A., De Stefano, D.V., Sander, C., Kunning, S.R., Najjar, Y.G., Davar, D., Luke, J.J., Gooding, W., Bruno, T.C., Kirkwood, J.M., & Storkus, W.J. (2023). Expression of lymphoid structure-associated cytokine/chemokine gene transcripts in tumor and protein in serum are prognostic of melanoma patient outcomes. FRONTIERS IN IMMUNOLOGY, 14, 1171978.Frontiers Media SA. doi: 10.3389/fimmu.2023.1171978.

Bellavia, M.C., Nyiranshuti, L., Latoche, J.D., Ho, K.V., Fecek, R.J., Taylor, J.L., Day, K.E., Nigam, S., Pun, M., Gallazzi, F., Edinger, R.S., Storkus, W.J., Patel, R.B., & Anderson, C.J. (2022). PET Imaging of VLA-4 in a New BRAFV600E Mouse Model of Melanoma. MOLECULAR IMAGING AND BIOLOGY, 24(3), 425-433.Springer Science and Business Media LLC. doi: 10.1007/s11307-021-01666-1.

Filderman, J.N., & Storkus, W.J. (2022). Finding the right help in the tumor microenvironment. JOURNAL OF CLINICAL INVESTIGATION, 132(12).American Society for Clinical Investigation. doi: 10.1172/JCI161052.

Gruenwald, V., & Storkus, W.J. (2022). Editorial: Immunotherapy in renal cell carcinoma. FRONTIERS IN ONCOLOGY, 12, 945510.Frontiers Media SA. doi: 10.3389/fonc.2022.945510.

Karapetyan, L., Gooding, W., Li, A., Yang, X., Knight, A., Abushukair, H.M., De Stefano, D.V., Sander, C., Karunamurthy, A., Panelli, M., Storkus, W.J., Tarhini, A.A., & Kirkwood, J.M. (2022). Sentinel Lymph Node Gene Expression Signature Predicts Recurrence-Free Survival in Cutaneous Melanoma. CANCERS, 14(20), 4973.MDPI AG. doi: 10.3390/cancers14204973.

Karapetyan, L., Yang, X., Knight, A.D., Huang, Z., Wang, H., Sander, C.A., Minnier, C.P., Wilson, M., Li, A., Karunamurthy, A., Storkus, W.J., & Kirkwood, J.M. (2022). Poorer survival outcomes in patients with multiple versus single primary melanoma. CANCER, 128(11), 2098-2106.Wiley. doi: 10.1002/cncr.34169.

Tarhini, A.A., Lee, S.J., Tan, A.C., El Naqa, I.M., Hodi, F.S., Butterfield, L.H., LaFramboise, W.A., Storkus, W.J., Karunamurthy, A.D., Conejo-Garcia, J.R., Hwu, P., Streicher, H., Sondak, V.K., & Kirkwood, J.M. (2022). Improved prognosis and evidence of enhanced immunogenicity in tumor and circulation of high-risk melanoma patients with unknown primary. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 10(1), e004310.BMJ. doi: 10.1136/jitc-2021-004310.

Vats, K., Kruglov, O., Sahoo, B., Soman, V., Zhang, J., Shurin, G.V., Chandran, U.R., Skums, P., Shurin, M.R., Zelikovsky, A., Storkus, W.J., & Bunimovich, Y.L. (2022). Sensory Nerves Impede the Formation of Tertiary Lymphoid Structures and Development of Protective Antimelanoma Immune Responses. Cancer Immunol Res, 10(9), 1141-1154.American Association for Cancer Research (AACR). doi: 10.1158/2326-6066.CIR-22-0110.

Amouzegar, A., Chelvanambi, M., Filderman, J.N., Storkus, W.J., & Luke, J.J. (2021). STING Agonists as Cancer Therapeutics. CANCERS, 13(11), 2695.MDPI AG. doi: 10.3390/cancers13112695.

Chelvanambi, M., Fecek, R.J., Taylor, J.L., & Storkus, W.J. (2021). STING agonist-based treatment promotes vascular normalization and tertiary lymphoid structure formation in the therapeutic melanoma microenvironment. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 9(2), e001906.BMJ. doi: 10.1136/jitc-2020-001906.

Close, D.A., Kirkwood, J.M., Fecek, R.J., Storkus, W.J., & Johnston, P.A. (2021). Unbiased High-Throughput Drug Combination Pilot Screening Identifies Synergistic Drug Combinations Effective against Patient-Derived and Drug-Resistant Melanoma Cell Lines. SLAS DISCOVERY, 26(5), 712-729.Elsevier BV. doi: 10.1177/2472555220970917.

Dai, E., Zhu, Z., Wahed, S., Qu, Z., Storkus, W.J., & Guo, Z.S. (2021). Epigenetic modulation of antitumor immunity for improved cancer immunotherapy. MOLECULAR CANCER, 20(1), 171.Springer Science and Business Media LLC. doi: 10.1186/s12943-021-01464-x.

Dasgupta, S., Ghosh, T., Dhar, J., Bhuniya, A., Nandi, P., Das, A., Saha, A., Das, J., Guha, I., Banerjee, S., Chakravarti, M., Dasgupta, P.S., Alam, N., Chakrabarti, J., Majumdar, S., Chakrabarti, P., Storkus, W.J., Baral, R., & Bose, A. (2021). RGS5-TGFβ-Smad2/3 axis switches pro- to anti-apoptotic signaling in tumor-residing pericytes, assisting tumor growth. CELL DEATH AND DIFFERENTIATION, 28(11), 3052-3076.Springer Science and Business Media LLC. doi: 10.1038/s41418-021-00801-3.

Filderman, J.N., Appleman, M., Chelvanambi, M., Taylor, J.L., & Storkus, W.J. (2021). STINGing the Tumor Microenvironment to Promote Therapeutic Tertiary Lymphoid Structure Development. FRONTIERS IN IMMUNOLOGY, 12, 690105.Frontiers Media SA. doi: 10.3389/fimmu.2021.690105.

Hao, X., Falo III, L.D., Chen, G., Zhang, J., Carey, C.D., Storkus, W.J., Falo Jr, L.D., & You, Z. (2021). Skin immunization for effective treatment of multifocal melanoma refractory to PD1 blockade and Braf inhibitors. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 9(1), e001179.BMJ. doi: 10.1136/jitc-2020-001179.

Lejeune, F.J., Storkus, W.J., & Riley, P.A. (2021). Thirty years of therapeutic innovation in melanoma research. MELANOMA RESEARCH, 31(2), 105-107.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/CMR.0000000000000723.

Pontrelli, P., Gigante, M., Spadaccino, F., Netti, G.S., Saldarelli, M., Balducci, L., Gigante, M., Battaglia, M., Storkus, W.J., Castellano, G., Stallone, G., Gesualdo, L., & Ranieri, E. (2021). CD40 Cross-Linking Induces Migration of Renal Tumor Cell through Nuclear Factor of Activated T Cells (NFAT) Activation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(16), 8871.MDPI AG. doi: 10.3390/ijms22168871.

Salem, D., Chelvanambi, M., Storkus, W.J., & Fecek, R.J. (2021). Cutaneous Melanoma: Mutational Status and Potential Links to Tertiary Lymphoid Structure Formation. FRONTIERS IN IMMUNOLOGY, 12, 629519.Frontiers Media SA. doi: 10.3389/fimmu.2021.629519.

Storkus, W.J., Maurer, D., Lin, Y., Ding, F., Bose, A., Lowe, D., Rose, A., DeMark, M., Karapetyan, L., Taylor, J.L., Chelvanambi, M., Fecek, R.J., Filderman, J.N., Looney, T.J., Miller, L., Linch, E., Lowman, G.M., Kalinski, P., Butterfield, L.H., Tarhini, A., Tawbi, H., & Kirkwood, J.M. (2021). Dendritic cell vaccines targeting tumor blood vessel antigens in combination with dasatinib induce therapeutic immune responses in patients with checkpoint-refractory advanced melanoma. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 9(11), e003675.BMJ. doi: 10.1136/jitc-2021-003675.

Allen, A., Gau, D., Francoeur, P., Sturm, J., Wang, Y., Martin, R., Maranchie, J., Duensing, A., Kaczorowski, A., Duensing, S., Wu, L., Lotze, M.T., Koes, D., Storkus, W.J., & Roy, P. (2020). Actin-binding protein profilin1 promotes aggressiveness of clear-cell renal cell carcinoma cells. JOURNAL OF BIOLOGICAL CHEMISTRY, 295(46), 15636-15649.Elsevier BV. doi: 10.1074/jbc.RA120.013963.

Chelvanambi, M., Weinstein, A.M., & Storkus, W.J. (2020). IL-36 Signaling in the Tumor Microenvironment. TUMOR MICROENVIRONMENT: THE ROLE OF INTERLEUKINS, PT A, 1240, 95-110.Springer International Publishing. doi: 10.1007/978-3-030-38315-2_8.

Filderman, J.N., & Storkus, W.J. (2020). Neoepitopes as Difference Makers for General Cancer Vaccines?. CLINICAL CANCER RESEARCH, 26(17), 4429-4431.American Association for Cancer Research (AACR). doi: 10.1158/1078-0432.CCR-20-2127.

Guha, I., Bhuniya, A., Shukla, D., Patidar, A., Nandi, P., Saha, A., Dasgupta, S., Ganguly, N., Ghosh, S., Nair, A., Majumdar, S., Saha, B., Storkus, W.J., Baral, R., & Bose, A. (2020). Tumor Arrests DN2 to DN3 Pro T Cell Transition and Promotes Its Conversion to Thymic Dendritic Cells by Reciprocally Regulating Notch1 and Ikaros Signaling. FRONTIERS IN IMMUNOLOGY, 11, 898.Frontiers Media SA. doi: 10.3389/fimmu.2020.00898.

Guo, Z.S., Lotze, M.T., Zhu, Z., Storkus, W.J., & Song, X.T. (2020). Bi- and Tri-Specific T Cell Engager-Armed Oncolytic Viruses: Next-Generation Cancer Immunotherapy. BIOMEDICINES, 8(7), 204.MDPI AG. doi: 10.3390/biomedicines8070204.

Hwang, M.P., Fecek, R.J., Qin, T., Storkus, W.J., & Wang, Y. (2020). Single injection of IL-12 coacervate as an effective therapy against B16-F10 melanoma in mice. JOURNAL OF CONTROLLED RELEASE, 318, 270-278.Elsevier BV. doi: 10.1016/j.jconrel.2019.12.035.

Maurer, D.M., Adamik, J., Santos, P.M., Shi, J., Shurin, M.R., Kirkwood, J.M., Storkus, W.J., & Butterfield, L.H. (2020). Dysregulated NF-κB-Dependent ICOSL Expression in Human Dendritic Cell Vaccines Impairs T-cell Responses in Patients with Melanoma. CANCER IMMUNOLOGY RESEARCH, 8(12), 1554-1567.American Association for Cancer Research (AACR). doi: 10.1158/2326-6066.CIR-20-0274.

Razzo, B.M., Ludwig, N., Hong, C.S., Sharma, P., Fabian, K.P., Fecek, R.J., Storkus, W.J., & Whiteside, T.L. (2020). Tumor-derived exosomes promote carcinogenesis of murine oral squamous cell carcinoma. CARCINOGENESIS, 41(5), 625-633.Oxford University Press (OUP). doi: 10.1093/carcin/bgz124.

Guo, Z.S., Lu, B., Guo, Z., Giehl, E., Feist, M., Dai, E., Liu, W., Storkus, W.J., He, Y., Liu, Z., & Bartlett, D.L. (2019). Vaccinia virus-mediated cancer immunotherapy: cancer vaccines and oncolytics. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 7(1), 6.BMJ. doi: 10.1186/s40425-018-0495-7.

Ludwig, S., Hong, C.S., Razzo, B.M., Fabian, K.P.L., Chelvanambi, M., Lang, S., Storkus, W.J., & Whiteside, T.L. (2019). Impact of combination immunochemotherapies on progression of 4NQO-induced murine oral squamous cell carcinoma. CANCER IMMUNOLOGY IMMUNOTHERAPY, 68(7), 1133-1141.Springer Science and Business Media LLC. doi: 10.1007/s00262-019-02348-2.

Russell, K.L., Gorgulho, C.M., Allen, A., Vakaki, M., Wang, Y., Facciabene, A., Lee, D., Roy, P., Buchser, W.J., Appleman, L.J., Maranchie, J., Storkus, W.J., & Lotze, M.T. (2019). Inhibiting Autophagy in Renal Cell Cancer and the Associated Tumor Endothelium. CANCER JOURNAL, 25(3), 165-177.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/PPO.0000000000000374.

Weinstein, A.M., Giraldo, N.A., Petitprez, F., Julie, C., Lacroix, L., Peschaud, F., Emile, J.F., Marisa, L., Fridman, W.H., Storkus, W.J., & Sautes-Fridman, C. (2019). Association of IL-36 with tertiary lymphoid structures and inflammatory immune infiltrates in human colorectal cancer. CANCER IMMUNOLOGY IMMUNOTHERAPY, 68(1), 109-120.Springer Science and Business Media LLC. doi: 10.1007/s00262-018-2259-0.

Choi, J., Beaino, W., Fecek, R.J., Fabian, K.P.L., Laymon, C.M., Kurland, B.F., Storkus, W.J., & Anderson, C.J. (2018). Combined VLA-4-Targeted Radionuclide Therapy and Immunotherapy in a Mouse Model of Melanoma. JOURNAL OF NUCLEAR MEDICINE, 59(12), 1843-1849.Society of Nuclear Medicine. doi: 10.2967/jnumed.118.209510.

Fecek, R.J., Raveendran, S., Chelvanambi, M., & Storkus, W.J. (2018). Inhibition of HSPs for Enhanced Immunity. In Heat Shock Proteins in the Immune System. (pp. 157-180).Springer International Publishing. doi: 10.1007/978-3-319-69042-1_9.

Fabian, K.L., & Storkus, W.J. (2017). Immunotherapeutic Targeting of Tumor-Associated Blood Vessels. TUMOR IMMUNE MICROENVIRONMENT IN CANCER PROGRESSION AND CANCER THERAPY, 1036, 191-211.Springer International Publishing. doi: 10.1007/978-3-319-67577-0_13.

Fabian, K.P.L., Chi-Sabins, N., Taylor, J.L., Fecek, R., Weinstein, A., & Storkus, W.J. (2017). Therapeutic efficacy of combined vaccination against tumor pericyte-associated antigens DLK1 and DLK2 in mice. ONCOIMMUNOLOGY, 6(3), e1290035.Informa UK Limited. doi: 10.1080/2162402X.2017.1290035.

Guo, Z.S., Liu, Z., Kowalsky, S., Feist, M., Kalinski, P., Lu, B., Storkus, W.J., & Bartlett, D.L. (2017). Oncolytic immunotherapy: Conceptual evolution, Current Strategies, and Future Perspectives. FRONTIERS IN IMMUNOLOGY, 8(MAY), 555.Frontiers Media SA. doi: 10.3389/fimmu.2017.00555.

Liu, Z., Hao, X., Zhang, Y., Zhang, J., Carey, C.D., Falo, L.D., Storkus, W.J., & You, Z. (2017). Intratumoral delivery of tumor antigen-loaded DC and tumor-primed CD4+ T cells combined with agonist -GITR mAb promotes durable CD8+ T-cell-dependent antitumor immunity. ONCOIMMUNOLOGY, 6(6), e1315487.Informa UK Limited. doi: 10.1080/2162402X.2017.1315487.

Vujanovic, L., Stahl, E.C., Pardee, A.D., Geller, D.A., Tsung, A., Watkins, S.C., Gibson, G.A., Storkus, W.J., & Butterfield, L.H. (2017). Tumor-Derived α-Fetoprotein Directly Drives Human Natural Killer-Cell Activation and Subsequent Cell Death. CANCER IMMUNOLOGY RESEARCH, 5(6), 493-502.American Association for Cancer Research (AACR). doi: 10.1158/2326-6066.CIR-16-0216.

Weinstein, A.M., Chen, L., Brzana, E.A., Patil, P.R., Taylor, J.L., Fabian, K.L., Wallace, C.T., Jones, S.D., Watkins, S.C., Lu, B., Stroncek, D.F., Denning, T.L., Fu, Y.X., Cohen, P.A., & Storkus, W.J. (2017). Tbet and IL-36 cooperate in therapeutic DC-mediated promotion of ectopic lymphoid organogenesis in the tumor microenvironment. ONCOIMMUNOLOGY, 6(6), e1322238.Informa UK Limited. doi: 10.1080/2162402X.2017.1322238.

Fecek, R.J., & Storkus, W.J. (2016). Combination strategies to enhance the potency of monocyte-derived dendritic cell-based cancer vaccines. IMMUNOTHERAPY, 8(10), 1205-1218.Future Medicine Ltd. doi: 10.2217/imt-2016-0071.

Ghosh, T., Barik, S., Bhuniya, A., Dhar, J., Dasgupta, S., Ghosh, S., Sarkar, M., Guha, I., Sarkar, K., Chakrabarti, P., Saha, B., Storkus, W.J., Baral, R., & Bose, A. (2016). Tumor-associated mesenchymal stem cells inhibit naive T cell expansion by blocking cysteine export from dendritic cells. INTERNATIONAL JOURNAL OF CANCER, 139(9), 2068-2081.Wiley. doi: 10.1002/ijc.30265.

Gigante, M., Pontrelli, P., Herr, W.Gigante, M., D'Avenia, M., Zaza, G., Cavalcanti, E., Accetturo, M., Lucarelli, G., Carrieri, G., Battaglia, M., Storkus, W.J., Gesualdo, L., & Ranieri, E. (2016). miR-29b and miR-198 overexpression in CD8+ T cells of renal cell carcinoma patients down-modulates JAK3 and MCL-1 leading to immune dysfunction. JOURNAL OF TRANSLATIONAL MEDICINE, 14(1), 84.Springer Science and Business Media LLC. doi: 10.1186/s12967-016-0841-9.

Raich-Regue, D., Fabian, K.P., Watson, A.R., Fecek, R.J., Storkus, W.J., & Thomson, A.W. (2016). Intratumoral delivery of mTORC2-deficient dendritic cells inhibits B16 melanoma growth by promoting CD8+ effector T cell responses. ONCOIMMUNOLOGY, 5(6), e1146841.Informa UK Limited. doi: 10.1080/2162402X.2016.1146841.

Tarhini, A.A., Tawbi, H., & Storkus, W.J. (2016). Vaccine therapy + dasatinib for the treatment of patients with stage IIIB-IV melanoma. Melanoma Manag, 3(4), 251-254.Future Medicine Ltd. doi: 10.2217/mmt-2016-0016.

Weinstein, A.M., & Storkus, W.J. (2016). Biosynthesis and Functional Significance of Peripheral node Addressin in Cancer-Associated TLO. FRONTIERS IN IMMUNOLOGY, 7(AUG), 301.Frontiers Media SA. doi: 10.3389/fimmu.2016.00301.

Lowe, D.B., Finke, J.H., Garcia, J.A., & Storkus, W.J. (2015). Vaccines in RCC: Clinical and Biological Relevance. 483-525.Springer New York. doi: 10.1007/978-1-4939-1622-1_22.

Wang, X., Zhao, X., Feng, C., Weinstein, A., Xia, R., Wen, W., Lv, Q., Zuo, S., Tang, P., Yang, X., Chen, X., Wang, H., Zang, S., Stollings, L., Denning, T.L., Jiang, J., Fan, J., Zhang, G., Zhang, X., Zhu, Y., Storkus, W., & Lu, B. (2015). IL-36γ Transforms the Tumor Microenvironment and Promotes Type 1 Lymphocyte-Mediated Antitumor Immune Responses. CANCER CELL, 28(3), 296-306.Elsevier BV. doi: 10.1016/j.ccell.2015.07.014.

Weinstein, A.M., & Storkus, W.J. (2015). Therapeutic Lymphoid Organogenesis in the Tumor Microenvironment. IMMUNOTHERAPY OF CANCER, 128, 197-233.Elsevier. doi: 10.1016/bs.acr.2015.04.003.

Zhang, Y., Chen, G., Liu, Z., Tian, S., Zhang, J., Carey, C.D., Murphy, K.M., Storkus, W.J., Jr, F.L.D., & You, Z. (2015). Genetic Vaccines To Potentiate the Effective CD103+ Dendritic Cell-Mediated Cross-Priming of Antitumor Immunity. JOURNAL OF IMMUNOLOGY, 194(12), 5937-5947.The American Association of Immunologists. doi: 10.4049/jimmunol.1500089.

Lowe, D.B., Bose, A., Taylor, J.L., Tawbi, H., Lin, Y., Kirkwood, J.M., & Storkus, W.J. (2014). Dasatinib promotes the expansion of a therapeutically superior T-cell repertoire in response to dendritic cell vaccination against melanoma. ONCOIMMUNOLOGY, 3(2), e27589.Informa UK Limited. doi: 10.4161/onci.27589.

Lowe, D.B., Taylor, J.L., & Storkus, W.J. (2014). Monitoring antigen-specific T cell responses using real-time PCR. Methods Mol Biol, 1186, 65-74.Springer New York. doi: 10.1007/978-1-4939-1158-5_5.

Storkus, W., Taylor, J., Lowe, D., Bose, A., Lin, Y., Kirkwood, J., & Tawbi, H. (2014). Dasatinib promotes an expanded and therapeutically-superior T cell repertoire in response to vaccination against melanoma. JOURNAL OF IMMUNOLOGY, 192(1), e27589. doi: 10.4161/onci.27589.

Vujanovic, L., Shi, J., Kirkwood, J.M., Storkus, W.J., & Butterfield, L.H. (2014). Molecular mimicry of MAGE-A6 and Mycoplasma penetrans HF-2 epitopes in the induction of antitumor CD8+ T-cell responses. ONCOIMMUNOLOGY, 3(8), e954501.Informa UK Limited. doi: 10.4161/21624011.2014.954501.

Wesa, A.K., Mandic, M., Taylor, J.L., Moschos, S., Kirkwood, J.M., Kwok, W.W., Finke, J.H., & Storkus, W.J. (2014). Circulating type-1 anti-tumor CD4+ T cells are preferentially pro-apoptotic in cancer patients. Frontiers in Oncology, 4 AUG. doi: 10.3389/fonc.2014.00225.

Wesa, A.K., Mandic, M., Taylor, J.L., Moschos, S., Kirkwood, J.M., Kwok, W.W., Finke, J.H., & Storkus, W.J. (2014). Circulating Type-1 Anti-Tumor CD4(+) T Cells are Preferentially Pro-Apoptotic in Cancer Patients. Front Oncol, 4, 266.Frontiers Media SA. doi: 10.3389/fonc.2014.00266.

Zhang, Y., Tian, S., Liu, Z., Zhang, J., Zhang, M., Bosenberg, M.W., Kedl, R.M., Waldmann, T.A., Storkus, W.J., Jr, F.L.D., & You, Z. (2014). Dendritic cell-derived interleukin-15 is crucial for therapeutic cancer vaccine potency. ONCOIMMUNOLOGY, 3(10), e959321.Informa UK Limited. doi: 10.4161/21624011.2014.959321.

Bose, A., Barik, S., Banerjee, S., Ghosh, T., Mallick, A., Majumdar, S.B., Goswami, K.K., Bhuniya, A., Banerjee, S., Baral, R., Storkus, W.J., Dasgupta, P.S., & Majumdar, S. (2013). Tumor-Derived Vascular Pericytes Anergize Th Cells. JOURNAL OF IMMUNOLOGY, 191(2), 971-981.The American Association of Immunologists. doi: 10.4049/jimmunol.1300280.

Bose, A., Lowe, D.B., Rao, A., & Storkua, W.J. (2013). Combined vaccine + axitinib therapy yields superior antitumor efficacy in a murine melanoma model (vol 22, pg 236, 2012). MELANOMA RESEARCH, 23(2), 179.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/CMR.0b013e32835857a2.

Chen, L., Fabian, K.L., Taylor, J.L., & Storkus, W.J. (2013). Therapeutic use of dendritic cells to promote the extranodal priming of anti-tumor immunity. FRONTIERS IN IMMUNOLOGY, 4, 388.Frontiers Media SA. doi: 10.3389/fimmu.2013.00388.

Chen, L., Taylor, J.L., Sabins, N.C., Lowe, D.B., Qu, Y., You, Z., & Storkus, W.J. (2013). Extranodal induction of therapeutic immunity in the tumor microenvironment after intratumoral delivery of Tbet gene-modified dendritic cells. CANCER GENE THERAPY, 20(8), 469-477.Springer Science and Business Media LLC. doi: 10.1038/cgt.2013.42.

Janelsins, B.M., Sumpter, T.L., Tkacheva, O.A., Rojas-Canales, D.M., Erdos, G., Mathers, A.R., Shufesky, W.J., Storkus, W.J., Jr, F.L.D., Morelli, A.E., & Larregina, A.T. (2013). Neurokinin-1 receptor agonists bias therapeutic dendritic cells to induce type 1 immunity by licensing host dendritic cells to produce IL-12. BLOOD, 121(15), 2923-2933.American Society of Hematology. doi: 10.1182/blood-2012-07-446054.

Sabins, N.C., Taylor, J.L., Fabian, K.P.L., Appleman, L.J., Maranchie, J.K., Stolz, D.B., & Storkus, W.J. (2013). DLK1: A Novel Target for Immunotherapeutic Remodeling of the Tumor Blood Vasculature. MOLECULAR THERAPY, 21(10), 1958-1968.Elsevier BV. doi: 10.1038/mt.2013.133.

Sabins, N.C., Taylor, J.L., Lowe, D.B., & Storkus, W.J. (2013). Molecular Immunotherapeutics and Vaccines for Renal Cell Carcinoma and Its Vasculature. In Molecular Vaccines. 1, (pp. 371-383).Springer Vienna. doi: 10.1007/978-3-7091-1419-3_22.

Bose, A., Lowe, D.B., Rao, A., & Storkus, W.J. (2012). Combined vaccine plus axitinib therapy yields superior antitumor efficacy in a murine melanoma model. MELANOMA RESEARCH, 22(3), 236-243.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/CMR.0b013e3283538293.

Cohen, P.A., Ko, J.S., Storkus, W.J., Spencer, C.D., Bradley, J.M., Gorman, J.E., McCurry, D.B., Zorro-Manrique, S., Dominguez, A.L., Pathangey, L.B., Rayman, P.A., Rini, B.I., Gendler, S.J., & Finke, J.H. (2012). Myeloid-derived Suppressor Cells Adhere to Physiologic STAT3- vs STAT5-dependent Hematopoietic Programming, Establishing Diverse Tumor-Mediated Mechanisms of Immunologic Escape. IMMUNOLOGICAL INVESTIGATIONS, 41(6-7), 680-710.Informa UK Limited. doi: 10.3109/08820139.2012.703745.

Qu, Y., Chen, L., Lowe, D.B., Storkus, W.J., & Taylor, J.L. (2012). Combined Tbet and IL12 Gene Therapy Elicits and Recruits Superior Antitumor Immunity In Vivo. MOLECULAR THERAPY, 20(3), 644-651.Elsevier BV. doi: 10.1038/mt.2011.283.

Rao, A., Lowe, D.B., & Storkus, W.J. (2012). Shock block for improved immunotherapy. ONCOIMMUNOLOGY, 1(8), 1427-1429.Informa UK Limited. doi: 10.4161/onci.21174.

Rao, A., Taylor, J.L., Chi-Sabins, N., Kawabe, M., Gooding, W.E., & Storkus, W.J. (2012). Combination Therapy with HSP90 Inhibitor 17-DMAG Reconditions the Tumor Microenvironment to Improve Recruitment of Therapeutic T cells. CANCER RESEARCH, 72(13), 3196-3206.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-12-0538.

Rao, A., Taylor, J.L., Chi-Sabins, N., Kawabe, M., Gooding, W.E., & Storkus, W.J. (2012). Combination Therapy with HSP90 Inhibitor 17-DMAG Reconditions the Tumor Microenvironment to Improve Recruitment of Therapeutic T Cells (vol 72, pg 3196, 2012). CANCER RESEARCH, 72(20), 5431.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-12-3249.

Zhao, X., Bose, A., Komita, H., Taylor, J.L., Chi, N., Lowe, D.B., Okada, H., Cao, Y., Mukhopadhyay, D., Cohen, P.A., & Storkus, W.J. (2012). Vaccines Targeting Tumor Blood Vessel Antigens Promote CD8+ T Cell-Dependent Tumor Eradication or Dormancy in HLA-A2 Transgenic Mice. JOURNAL OF IMMUNOLOGY, 188(4), 1782-1788.The American Association of Immunologists. doi: 10.4049/jimmunol.1101644.

Bose, A., Taylor, J.L., Alber, S., Watkins, S.C., Garcia, J.A., Rini, B.I., Ko, J.S., Cohen, P.A., Finke, J.H., & Storkus, W.J. (2011). Sunitinib facilitates the activation and recruitment of therapeutic anti-tumor immunity in concert with specific vaccination. INTERNATIONAL JOURNAL OF CANCER, 129(9), 2158-2170.Wiley. doi: 10.1002/ijc.25863.

Lowe, D.B., & Storkus, W.J. (2011). Chronic inflammation and immunologic-based constraints in malignant disease. IMMUNOTHERAPY, 3(10), 1265-1274.Future Medicine Ltd. doi: 10.2217/IMT.11.113.

Qu, Y., Taylor, J.L., Bose, A., & Storkus, W.J. (2011). Therapeutic effectiveness of intratumorally delivered dendritic cells engineered to express the pro-inflammatory cytokine, interleukin (IL)-32. CANCER GENE THERAPY, 18(9), 663-673.Springer Science and Business Media LLC. doi: 10.1038/cgt.2011.37.

Zhao, X., Bose, A., Komita, H., Taylor, J.L., Kawabe, M., Chi, N., Spokas, L., Lowe, D.B., Goldbach, C., Alber, S., Watkins, S.C., Butterfield, L.H., Kalinski, P., Kirkwood, J.M., & Storkus, W.J. (2011). Intratumoral IL-12 Gene Therapy Results in the Crosspriming of Tc1 Cells Reactive Against Tumor-associated Stromal Antigens. MOLECULAR THERAPY, 19(4), 805-814.Elsevier BV. doi: 10.1038/mt.2010.295.

Cavalcanti, E., Gigante, M., Mancini, V., Battaglia, M., Ditonno, P., Capobianco, C., Cincione, R.I., Selvaggi, F.P., Herr, W., Storkus, W.J., Gesualdo, L., & Ranieri, E. (2010). JAK3/STAT5/6 Pathway Alterations Are Associated with Immune Deviation in CD8+ T Cells in Renal Cell Carcinoma Patients. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2010, 935764.Hindawi Limited. doi: 10.1155/2010/935764.

Chi, N., Maranchie, J.K., Appleman, L.J., & Storkus, W.J. (2010). Update on vaccine development for renal cell cancer. Open Access J Urol, 2(1), 125-141. doi: 10.2147/rru.s7242.

Chi, N., Maranchie, J.K., Appleman, L.J., & Storkus, W.J. (2010). UPDATE ON VACCINE DEVELOPMENT FOR RENAL CELL CANCER. Open Access J Urol, 2010(2), 125-141.Informa UK Limited. doi: 10.2147/RRU.S7242.

Lipscomb, M.W., Taylor, J.L., Goldbach, C.J., Watkins, S.C., Wesa, A.K., & Storkus, W.J. (2010). DC expressing transgene Foxp3 are regulatory APC. EUROPEAN JOURNAL OF IMMUNOLOGY, 40(2), 480-493.Wiley. doi: 10.1002/eji.200939667.

Pardee, A.D., McCurry, D., Alber, S., Hu, P., Epstein, A.L., & Storkus, W.J. (2010). A Therapeutic OX40 Agonist Dynamically Alters Dendritic, Endothelial, and T Cell Subsets within the Established Tumor Microenvironment. CANCER RESEARCH, 70(22), 9041-9052.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-10-1369.

Qu, Y., Chen, L., Pardee, A.D., Taylor, J.L., Wesa, A.K., & Storkus, W.J. (2010). Intralesional Delivery of Dendritic Cells Engineered to Express T-bet Promotes Protective Type 1 Immunity and the Normalization of the Tumor Microenvironment. JOURNAL OF IMMUNOLOGY, 185(5), 2895-2902.The American Association of Immunologists. doi: 10.4049/jimmunol.1001294.

Schaubert, K.L., Price, D.A., Salkowitz, J.R., Sewell, A.K., Sidney, J., Asher, T.E., Blondelle, S.E., Adams, S., Marincola, F.M., Joseph, A., Sette, A., Douek, D.C., Ayyavoo, V., Storkus, W., Leung, M.Y., Ng, H.L., Yang, O.O., Goldstein, H., Wilson, D.B., & Kan-Mitchell, J. (2010). Generation of robust CD8+ T-cell responses against subdominant epitopes in conserved regions of HIV-1 by repertoire mining with mimotopes. EUROPEAN JOURNAL OF IMMUNOLOGY, 40(7), 1950-1962.Wiley. doi: 10.1002/eji.200940079.

Finn, O.J., Binder, R.J., Brickner, A.G., Butterfield, L.H., Ferris, R.L., Kalinski, P., Okada, H., Storkus, W.J., Whiteside, T.L., & Zarour, H.M. (2009). Human Tumor Antigens as Targets of Immunosurveillance and Candidates for Cancer Vaccines. In Tumor-Associated Antigens: Identification, Characterization, and Clinical Applications. (pp. 23-43).Wiley. doi: 10.1002/9783527625970.ch2.

Gigante, M., Blasi, A., Loverre, A., Mancini, V., Battaglia, M., Selvaggi, F.R., Maiorano, E., Napoli, A., Castellano, G., Storkus, W.J., Gesualdo, L., & Ranieri, E. (2009). Dysfunctional DC subsets in RCC patients: Ex vivo correction to yield an effective anti-cancer vaccine. MOLECULAR IMMUNOLOGY, 46(5), 893-901.Elsevier BV. doi: 10.1016/j.molimm.2008.09.015.

Kawabe, M., Herrem, C.J., Finke, J.H., & Storkus, W.J. (2009). EphA2: A Novel Target in Renal Cell Carcinoma. In Renal Cell Carcinoma. (pp. 347-366).Humana Press. doi: 10.1007/978-1-59745-332-5_20.

Kawabe, M., Mandic, M., Taylor, J.L., Vasquez, C.A., Wesa, A.K., Neckers, L.M., & Storkus, W.J. (2009). Heat Shock Protein 90 Inhibitor 17-Dimethylaminoethylamino-17-Demethoxygeldanamycin Enhances EphA2+ Tumor Cell Recognition by Specific CD8+ T Cells. CANCER RESEARCH, 69(17), 6995-7003.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-08-4511.

Komita, H., Zhao, X., Katakam, A.K., Kumar, P., Kawabe, M., Okada, H., Braughler, J.M., & Storkus, W.J. (2009). Conditional interleukin-12 gene therapy promotes safe and effective antitumor immunity. CANCER GENE THERAPY, 16(12), 883-891.Springer Science and Business Media LLC. doi: 10.1038/cgt.2009.33.

Lipscomb, M.W., Chen, L., Taylor, J.L., Goldbach, C., Watkins, S.C., Kalinski, P., Butterfield, L.H., Wesa, A.K., & Storkus, W.J. (2009). Ectopic T-bet Expression Licenses Dendritic Cells for IL-12-Independent Priming of Type 1 T Cells In Vitro. JOURNAL OF IMMUNOLOGY, 183(11), 7250-7258.The American Association of Immunologists. doi: 10.4049/jimmunol.0901477.

Lipscomb, M.W., Storkus, W.J., & Wesa, A.K. (2009). Dendritic Cell Maturation Versus Polarization in Tumor Escape. In Dendritic Cells in Cancer. (pp. 257-268).Springer US. doi: 10.1007/978-0-387-88611-4_18.

Pardee, A.D., Wesa, A.K., & Storkus, W.J. (2009). Integrating costimulatory agonists to optimize immune-based cancer therapies. Immunotherapy, 1(2), 249-264.Future Medicine Ltd. doi: 10.2217/1750743X.1.2.249.

Pardee, A.D., Wesa, A.K., & Storkus, W.J. (2009). Integrating costimulatory agonists to optimize immune-based cancer therapies. IMMUNOTHERAPY, 1(2), 249-264. doi: 10.2217/1750743X.1.2.249.

Sasaki, K., Pardee, A.D., Qu, Y., Zhao, X., Ueda, R., Kohanbash, G., Bailey, L.M., Okada, H., Muthuswamy, R., Kalinski, P., Basse, P.H., Falo, L.D., & Storkus, W.J. (2009). IL-4 Suppresses Very Late Antigen-4 Expression Which is Required for Therapeutic Th1 T-cell Trafficking Into Tumors. JOURNAL OF IMMUNOTHERAPY, 32(8), 793-802.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/CJI.0b013e3181acec1e.

Wieckowski, E.U., Visus, C., Szajnik, M., Szczepanski, M.J., Storkus, W.J., & Whiteside, T.L. (2009). Tumor-Derived Microvesicles Promote Regulatory T Cell Expansion and Induce Apoptosis in Tumor-Reactive Activated CD8+ T Lymphocytes. JOURNAL OF IMMUNOLOGY, 183(6), 3720-3730.The American Association of Immunologists. doi: 10.4049/jimmunol.0900970.

Gigante, M., Mandic, M., Wesa, A.K., Cavalcanti, E., Dambrosio, M., Mancini, V., Battaglia, M., Gesualdo, L., Storkus, W.J., & Ranieri, E. (2008). Interferon-alpha (IFN-α)-conditioned DC preferentially stimulate type-1 and limit Treg-type in vitro T-cell responses from RCC patients. JOURNAL OF IMMUNOTHERAPY, 31(3), 254-262.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/CJI.0b013e318167b023.

Komita, H., Zhao, X., Taylor, J.L., Sparvero, L.J., Amoscato, A.A., Alber, S., Watkins, S.C., Pardee, A.D., Wesa, A.K., & Storkus, W.J. (2008). CD8+ T-cell responses against hemoglobin-β prevent solid tumor growth. CANCER RESEARCH, 68(19), 8076-8084.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-08-0387.

Moschos, S.J., Mandic, M., Kirkwood, J.M., Storkus, W.J., & Lotze, M.T. (2008). Focus on FOCIS: interleukin 2 treatment associated autoimmunity. Clin Immunol, 127(2), 123-129.Elsevier BV. doi: 10.1016/j.clim.2008.02.011.

Moschos, S.J., Mandic, M., Kirkwood, J.M., Storkus, W.J., & Lotze, M.T. (2008). Focus on FOCIS: Interleukin 2 treatment associated autoimmunity. CLINICAL IMMUNOLOGY, 127(2), 123-129. doi: 10.1016/j.clim.2008.02.011.

Sasaki, K., Pardee, A.D., Okada, H., & Storkus, W.J. (2008). IL-4 inhibits VLA-4 expression on Tc1 cells resulting in poor tumor infiltration and reduced therapy benefit. EUROPEAN JOURNAL OF IMMUNOLOGY, 38(10), 2865-2873.Wiley. doi: 10.1002/eji.200838334.

Sasaki, K., Zhao, X., Pardee, A.D., Ueda, R., Fujita, M., Sehra, S., Kaplan, M.H., Kane, L.P., Okada, H., & Storkus, W.J. (2008). Stat6 signaling suppresses VLA-4 expression by CD8+ T cells and limits their ability to infiltrate tumor lesions in vivo. JOURNAL OF IMMUNOLOGY, 181(1), 104-108.The American Association of Immunologists. doi: 10.4049/jimmunol.181.1.104.

Wesa, A.K., & Storkus, W.J. (2008). Killer dendritic cells: mechanisms of action and therapeutic implications for cancer. CELL DEATH AND DIFFERENTIATION, 15(1), 51-57.Springer Science and Business Media LLC. doi: 10.1038/sj.cdd.4402243.

Wesa, A.K., Herrem, C.J., Mandic, M., Taylor, J.L., Vasquez, C., Kawabe, M., Tatsumi, T., Leibowitz, M.S., Finke, J.H., Bukowski, R.M., Bruckheimer, E., Kinch, M.S., & Storkus, W.J. (2008). Enhancement in specific CD8+ T cell recognition of EphA2+ tumors in vitro and in vivo after treatment with ligand agonists. Journal of immunology (Baltimore, Md. : 1950), 181(11), 7721-7727.

Wesa, A.K., Herrem, C.J., Mandic, M., Taylor, J.L., Vasquez, C., Kawabe, M., Tatsumi, T., Leibowitz, M.S., Finke, J.H., Bukowski, R.M., Bruckheimer, E., Kinch, M.S., & Storkus, W.J. (2008). Enhancement in Specific CD8+ T Cell Recognition of EphA2+ Tumors In Vitro and In Vivo after Treatment with Ligand Agonists. JOURNAL OF IMMUNOLOGY, 181(11), 7721-7727.The American Association of Immunologists. doi: 10.4049/jimmunol.181.11.7721.

Atkins, M.B., Carbone, D., Coukos, G., Dhodapkar, M., Ernstoff, M.S., Finke, J., Gajewski, T.F., Gollob, J., Lotze, M.T., Storkus, W., & Weiner, L.M. (2007). Report on the ISBTC mini-symposium on biologic effects of targeted therapeutics. JOURNAL OF IMMUNOTHERAPY, 30(6), 577-590.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/CJI.0b013e318064e7b2.

Berhanu, A., Huang, J., Watkins, S.C., Okada, H., & Storkus, W.J. (2007). Treatment-enhanced CD4+ Foxp3+ glucocorticoid-induced TNF receptor family RelatedHigh regulatory tumor-infiltrating T cells limit the effectiveness of cytokine-based immunotherapy. JOURNAL OF IMMUNOLOGY, 178(6), 3400-3408.The American Association of Immunologists. doi: 10.4049/jimmunol.178.6.3400.

Nakamura, Y., Watchmaker, P., Urbau, J., Sheridan, B., Giermasz, A., Nishimura, F., Sasaki, K., Cumberland, R., Muthuswamy, R., Mailliard, R.B., Larregina, A.T., Falo, L.D., Gooding, W., Storkus, W.J., Okada, H., Hendricks, R.L., & Kalinski, P. (2007). Helper function of memory CD8+ T cells :: Heterologous CD8+ T cells support the induction of therapeutic cancer immunity. CANCER RESEARCH, 67(20), 10012-10018.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-07-1735.

Popescu, I., Macedo, C., Abu-Elmagd, K., Shapiro, R., Hua, Y., Thomson, A.W., Morelli, A.E., Storkus, W.J., & Metes, D. (2007). EBV-specific CD8+ T cell reactivation in transplant patients results in expansion of CD8+ type-1 regulatory T cells. AMERICAN JOURNAL OF TRANSPLANTATION, 7(5), 1215-1223.Elsevier BV. doi: 10.1111/j.1600-6143.2007.01740.x.

Ranieri, E., Gigante, M., Storkus, W.J., & Gesualdo, L. (2007). Translational mini-review series on vaccines: Dendritic cell-based vaccines in renal cancer. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 147(3), 395-400.Oxford University Press (OUP). doi: 10.1111/j.1365-2249.2006.03305.x.

Sasaki, K., Zhu, X., Vasquez, C., Nishimura, F., Dusak, J.E., Huang, J., Fujita, M., Wesa, A., Potter, D.M., Walker, P.R., Storkus, W.J., & Okada, H. (2007). Preferential expression of very late antigen-4 on type 1 CTL cells plays a critical role in trafficking into central nervous system tumors. CANCER RESEARCH, 67(13), 6451-6458.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-06-3280.

Storkus, W.J. (2007). Melanoma vaccines: in search of a clinical paradigm. MELANOMA RESEARCH, 17(3), 137-138.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/CMR.0b013e328153da7c.

Storkus, W.J., & Jr, F.L.D. (2007). A 'good death' for tumor immunology. NATURE MEDICINE, 13(1), 28-30.Springer Science and Business Media LLC. doi: 10.1038/nm0107-28.

Storkus, W.J., Herrem, C., Kawabe, M., Cohen, P.A., Bukowski, R.M., Finke, J.H., & Wesa, A.K. (2007). Improving immunotherapy by conditionally enhancing MHC class I presentation of tumor antigen-derived peptide Epitopes. CRITICAL REVIEWS IN IMMUNOLOGY, 27(5), 485-493.Begell House. doi: 10.1615/CritRevImmunol.v27.i5.60.

Tatsumi, T., Takehara, T., Yamaguchi, S., Sasakawa, A., Miyagi, T., Jinushi, M., Sakamori, R., Kohga, K., Uemura, A., Ohkawa, K., Storkus, W.J., & Hayashi, N. (2007). Injection of IL-12 gene-transduced dendritic cells into mouse liver tumor lesions activates both innate and acquired immunity. GENE THERAPY, 14(11), 863-871.Springer Science and Business Media LLC. doi: 10.1038/sj.gt.3302941.

Vujanovic, L., Mandic, M., Olson, W.C., Kirkwood, J.M., & Storkus, W.J. (2007). A mycoplasma peptide elicits heteroclitic CD4 T cell responses against tumor antigen MAGE-A6. CLINICAL CANCER RESEARCH, 13(22), 6796-6806.American Association for Cancer Research (AACR). doi: 10.1158/1078-0432.CCR-07-1909.

Wesa, A., Kalinski, P., Kirkwood, J.M., Tatsumi, T., & Storkus, W.J. (2007). Polarized type-1 dendritic cells (DC1) producing high levels of IL-12 family members rescue patient TH1-type antimelanoma CD4+ T cell responses in vitro. JOURNAL OF IMMUNOTHERAPY, 30(1), 75-82.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/01.cji.0000211316.15278.6e.

Yamaguchi, S., Tatsumi, T., Takehara, T., Sakamori, R., Uemura, A., Mizushima, T., Ohkawa, K., Storkus, W.J., & Hayashi, N. (2007). Immunotherapy of murine colon cancer using receptor tyrosine kinase EphA2-derived peptide-pulsed dendritic cell Vaccines. CANCER, 110(7), 1469-1477.Wiley. doi: 10.1002/cncr.22958.

Zhu, X., Nishimura, F., Sasaki, K., Fujita, M., Dusak, J.E., Eguchi, J., Fellows-Mayle, W., Storkus, W.J., Walker, P.R., Salazar, A.M., & Okada, H. (2007). Toll like receptor-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide epitopes in murine CNS tumor models. JOURNAL OF TRANSLATIONAL MEDICINE, 5(1), 10.Springer Science and Business Media LLC. doi: 10.1186/1479-5876-5-10.

Berhanu, A., Huang, J., Alber, S.M., Watkins, S.C., & Storkus, W.J. (2006). Combinational FLt3 ligand and granulocyte macrophage colony-stimulating factor treatment promotes enhanced tumor infiltration by dendritic cells and antitumor CD8+ T-cell cross-priming but is ineffective as a therapy. CANCER RESEARCH, 66(9), 4895-4903.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-05-2384.

Eguchi, J., Hatano, M., Nishimura, F., Zhu, X., Dusak, J.E., Sato, H., Pollack, I.F., Storkus, W.J., & Okada, H. (2006). Identification of interleukin-13 receptor α2 peptide analogues capable of inducing improved antiglioma CTL responses. CANCER RESEARCH, 66(11), 5883-5891.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-06-0363.

Nishimura, F., Dusak, J.E., Eguchi, J., Zhu, X.M., Gambotto, A., Storkus, W.J., & Okada, H. (2006). Adoptive transfer of type 1 CTL mediates effective anti-central nervous system tumor response: Critical roles of IFN-inducible protein-10. CANCER RESEARCH, 66(8), 4478-4487.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-05-3825.

Okano, F., Storkus, W.J., Chambers, W.H., Pollack, I.F., & Okada, H. (2006). Identification of a novel HLA-A* 0201-restricted, cytotoxic T lymphocyte epitope in a human glioma-associated antigen, interleukin 13 receptor α2 chain (vol 8, pg 2851, 2002). CLINICAL CANCER RESEARCH, 12(11), 3552. doi: 10.1158/1078-0432.CCR-12-11-COR.

Vujanovic, L., Ranieri, E., Gambotto, A., Olson, W.C., Kirkwood, J.M., & Storkus, W.J. (2006). IL-12p70 and IL-18 gene-modified dendritic cells loaded with tumor antigen-derived peptides or recombinant protein effectively stimulate specific Type-1 CD4+ T-cell responses from normal donors and melanoma patients in vitro. CANCER GENE THERAPY, 13(8), 798-805.Springer Science and Business Media LLC. doi: 10.1038/sj.cgt.7700964.

Wankowicz-Kalinska, A., Mailliard, R.B., Olson, K., Graham, F., Edington, H., Kirkwood, J.M., Martinek, S., Das, P.K., & Storkus, W.J. (2006). Accumulation of low-avidity anti-melanocortin receptor 1 (anti-MC1R) CD8+ T cells in the lesional skin of a patient with melanoma-related depigmentation. MELANOMA RESEARCH, 16(2), 165-174.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/01.cmr.0000198452.03957.73.

Eguchi, J., Kuwashima, N., Hatano, M., Nishimura, F., Dusak, J.E., Storkus, W.J., & Okada, H. (2005). IL-4-transfected tumor cell vaccines activate tumor-infiltrating dendritic cells and promote type-1 immunity. JOURNAL OF IMMUNOLOGY, 174(11), 7194-7201.The American Association of Immunologists. doi: 10.4049/jimmunol.174.11.7194.

Hatano, M., Eguchi, J., Tatsumi, T., Kuwashima, N., Dusak, J.E., Kinch, M.S., Pollack, I.F., Hamilton, R.L., Storkus, W.J., & Okada, H. (2005). EphA2 as a glioma-associated antigen: A novel target for glioma vaccines. NEOPLASIA, 7(8), 717-722.Elsevier BV. doi: 10.1593/neo.05277.

Herrem, C.J., Tatsumi, T., Olson, K.S., Shirai, K., Finke, J.H., Bukowski, R.M., Zhou, M., Richmond, A.L., Derweesh, I., Kinch, M.S., & Storkus, W.J. (2005). Expression of EphA2 is prognostic of disease-free interval and overall survival in surgically treated patients with renal cell carcinoma. CLINICAL CANCER RESEARCH, 11(1), 226-231.

Huang, J., Tatsumi, T., Pizzoferrato, E., Vujanovic, N., & Storkus, W.J. (2005). Nitric oxide sensitizes tumor cells to dendritic cell-mediated apoptosis, uptake, and cross-presentation. CANCER RESEARCH, 65(18), 8461-8470.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-05-0654.

Kalinski, P., Giermasz, A., Nakamura, Y., Basse, P., Storkus, W.J., Kirkwood, J.M., & Mailliard, R.B. (2005). Helper role of NK cells during the induction of anticancer responses by dendritic cells. Mol Immunol, 42(4), 535-539.Elsevier BV. doi: 10.1016/j.molimm.2004.07.038.

Kalinski, P., Giermasz, A., Nakamura, Y., Basse, P., Storkus, W.J., Kirkwood, J.M., & Mailliard, R.B. (2005). Helper role of NK cells during the induction of anticancer responses by dendritic cells. MOLECULAR IMMUNOLOGY, 42(4), 535-539.Elsevier BV. doi: 10.1016/j.molimm.2004.07.038.

Kalinski, P., Mailliard, R.B., Geskin, L., Giermasz, A., Nakamura, Y., Storkus, W.J., Lotze, M.T., Bartlett, D.L., Kirkwood, J.M., & Falo, L.D. (2005). Polarized DC1-based therapeutic cancer vaccines. JOURNAL OF IMMUNOTHERAPY, 28(6), 656.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/01.cji.0000191090.97275.78.

Kuwashima, N., Nishimura, F., Eguchi, J., Sato, H., Hatano, M., Tsugawa, T., Sakaida, T., Dusak, J.E., Fellows-Mayle, W.K., Papworth, G.D., Watkins, S.C., Gambotto, A., Pollack, I.F., Storkus, W.J., & Okada, H. (2005). Delivery of dendritic cells engineered to secrete IFN-α into central nervous system tumors enhances the efficacy of peripheral tumor cell vaccines:: Dependence on apoptotic pathways. JOURNAL OF IMMUNOLOGY, 175(4), 2730-2740.The American Association of Immunologists. doi: 10.4049/jimmunol.175.4.2730.

Macedo, C., Donnenberg, A., Popescu, I., Reyes, J., Abu-Elmagd, K., Shapiro, R., Zeevi, A., Fung, J.J., Storkus, W.J., & Metes, D. (2005). EBV-specific memory CD8+ T cell phenotype and function in stable solid organ transplant patients. TRANSPLANT IMMUNOLOGY, 14(2), 109-116.Elsevier BV. doi: 10.1016/j.trim.2005.02.001.

Macedo, C., Popescu, I., Abu-Elmagd, K., Reyes, J., Shapiro, R., Zeevi, A., Berghaus, J.M., Wang, L.F., Lu, L.N., Thomson, A.W., Storkus, W.J., Fung, J.J., & Metes, D. (2005). Augmentation of type-1 polarizing ability of monocyte-derived dendritic cells from chronically immunosuppressed organ-transplant recipients. TRANSPLANTATION, 79(4), 451-459.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/01.TP.0000146589.49756.7F.

Muller-Berghaus, J., Olson, W.C., Moulton, R.A., Knapp, W.T., Schadendorf, D., & Storkus, W.J. (2005). IL-12 production by human monocyte-derived dendritic cells - Looking at the single cell. JOURNAL OF IMMUNOTHERAPY, 28(4), 306-313.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/01.cji.0000163594.74533.10.

Warrino, D.E., Olson, W.C., Scarrow, M.I., D'Ambrosio-Brennan, L.J., Guido, R.S., Da Silva, D.M., Kast, W.M., & Storkus, W.J. (2005). Human papillomavirus L1L2-E7 virus-like particles partially mature human dendritic cells and elicit E7-specific T-helper responses from patients with cervical intraepithelial neoplasia or cervical cancer in vitro. HUMAN IMMUNOLOGY, 66(7), 762-772.Elsevier BV. doi: 10.1016/j.humimm.2005.04.006.

Hatano, M., Kuwashima, N., Tatsumi, T., Dusak, J.E., Nishimura, F., Reilly, K.M., Storkus, W.J., & Okada, H. (2004). Vaccination with EphA2-derived T cell-epitopes promotes immunity against both EphA2-expressing and EphA2-negative tumors. J Transl Med, 2(1), 40.Springer Science and Business Media LLC. doi: 10.1186/1479-5876-2-40.

Mailliard, R.B., Wankowicz-Kalinska, A., Cai, Q., Wesa, A., Hilkens, C.M., Kapsenberg, M.L., Kirkwood, J.M., Storkus, W.J., & Kalinski, P. (2004). α-type-1 polarized dendritic cells:: A novel immunization tool with optimized CTL-inducing activity. CANCER RESEARCH, 64(17), 5934-5937.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-04-1261.

Okada, H., Tsugawa, T., Sato, H., Kuwashima, N., Gambotto, A., Okada, K., Dusak, J.E., Fellows-Mayle, W.K., Papworth, G.D., Watkins, S.C., Chambers, W.H., Potter, D.M., Storkus, W.J., & Pollack, I.F. (2004). Delivery of interferon-α transfected dendritic cells into central nervous system tumors enhances the antitumor efficacy of peripheral peptide-based vaccines. CANCER RESEARCH, 64(16), 5830-5838.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-04-0130.

Pizzoferrato, E., Liu, Y., Gambotto, A., Armstrong, M.J., Stang, M.T., Gooding, W.E., Alber, S.M., Shand, S.H., Watkins, S.C., Storkus, W.J., & Yim, J.H. (2004). Ectopic expression of interferon regulatory factor-1 promotes human breast cancer cell death and results in reduced expression of survivin. CANCER RESEARCH, 64(22), 8381-8388.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-04-2223.

Rayman, P., Wesa, A.K., Richmond, A.L., Das, T., Biswas, K., Raval, G., Storkus, W.J., Tannenbaum, C., Novick, A., Bukowski, R., & Finke, J. (2004). Effect of renal cell carcinomas on the development of type 1 T-cell responses. CLINICAL CANCER RESEARCH, 10(18), 6360S-6366S.American Association for Cancer Research (AACR). doi: 10.1158/1078-0432.CCR-050011.

Warrino, D.E., Olson, W.C., Knapp, W.T., Scarrow, M.I., D'Ambrosio-Brennan, L.J., Guido, R.S., Edwards, R.P., Kast, W.M., & Storkus, W.J. (2004). Disease-stage variance in functional CD4+ T-cell responses against novel pan-human leukocyte antigen-D region presented human papillomavirus-16 E7 epitopes. CLINICAL CANCER RESEARCH, 10(10), 3301-3308.American Association for Cancer Research (AACR). doi: 10.1158/1078-0432.CCR-03-0498.

Hoffman, T.K., MullerBerghaus, J., Ferris, R.L., Johnson, J.T., Storkus, W.J., & Whiteside, T.L. (2003). Alterations in the frequency of dendritic cell subsets in the peripheral circulation of patients with squamous cell carcinomas of the head and neck (vol 8, pg 1787, 2002). CLINICAL CANCER RESEARCH, 9(1), 441.

Kalinski, P., Cai, Q., Mailliard, R.B., Kalinska, A., Storkus, W.J., & Kirkwood, J.M. (2003). Type-1 polarized DC obtained in serum-free conditions are powerful inducers of anti-melanoma responses. FASEB JOURNAL, 17(7), C331.

KALINSKI, P., STORKUS, W., THOMSON, A., & LOTZE, M. (2003). Interleukin-12 Family [IL-12, 23, 12RA and 27]. In The Cytokine Handbook. (pp. 383-408).Elsevier. doi: 10.1016/b978-012689663-3/50020-x.

Mailliard, R.B., Son, Y.I., Redlinger, R., Coates, P.T., Giermasz, A., Morel, P.A., Storkus, W.J., & Kalinski, P. (2003). Dendritic cells mediate NK cell help for Th1 and CTL responses: Two-signal requirement for the induction of NK cell helper function. JOURNAL OF IMMUNOLOGY, 171(5), 2366-2373.The American Association of Immunologists. doi: 10.4049/jimmunol.171.5.2366.

Nakahara, N., Pollack, I.F., Storkus, W.J., Wakabayashi, T., Yoshida, J., & Okada, H. (2003). Effective induction of antiglioma cytotoxic T cells by coadministration of interferon-β gene vector and dendritic cells. CANCER GENE THERAPY, 10(7), 549-558.Springer Science and Business Media LLC. doi: 10.1038/sj.cgt.7700598.

Popescu, L., Macedo, C., Zeevi, A., Nellis, J., Patterson, K.R., Logar, A., Rowe, D., Reyes, J., Rao, A.S., Storkus, W.J., Fung, J.J., & Metes, D. (2003). Ex vivo priming of naive T cells into EBV-specific Th1/Tc1 effector cells by mature autologous DC loaded with apoptotic/necrotic LCL. AMERICAN JOURNAL OF TRANSPLANTATION, 3(11), 1369-1377.Elsevier BV. doi: 10.1046/j.1600-6135.2003.00252.x.

ROBBINS, P., STORKUS, W., & GAMBOTTO, A. (2003). Cytokine gene transfer. In The Cytokine Handbook. (pp. 1335-1348).Elsevier. doi: 10.1016/b978-012689663-3/50063-6.

Tatsumi, T., Herrem, C.J., Olson, W.C., Finke, J.H., Bukowski, R.M., Kinch, M.S., Ranieri, E., & Storkus, W.J. (2003). Disease stage variation in CD4+ and CD8+ T-cell reactivity to the receptor tyrosine kinase EphA2 in patients with renal cell carcinoma. CANCER RESEARCH, 63(15), 4481-4489.

Tatsumi, T., Huang, J., Gooding, W.E., Gambotto, A., Robbins, P.D., Vujanovic, N.L., Alber, S.M., Watkins, S.C., Okada, H., & Storkus, W.J. (2003). Intratumoral delivery of dendritic cells engineered to secrete both interleukin (IL)-12 and IL-18 effectively treats local and distant disease in association with broadly reactive Tcl-type immunity. CANCER RESEARCH, 63(19), 6378-6386.

Tatsumi, T., Kierstead, L.S., Ranieri, E., Gesualdo, L., Schena, F.P., Finke, J.H., Bukowski, R.M., Brusic, V., Sidney, J., Sette, A., Logan, T.F., Kasamon, Y.L., Slingluff, C.L., Kirkwood, J.M., & Storkus, W.J. (2003). MAGE-6 encodes HLA-DRβ1*0401-presented Epitopes recognized by CD4+ T cells from patients with melanoma or renal cell carcinoma. CLINICAL CANCER RESEARCH, 9(3), 947-954.

Wankowicz-Kalinska, A., Le poole, C., Van Den Wijngaard, R., Storkus, W.J., & Das, P.K. (2003). Melanocyte-specific immune response in melanoma and vitiligo: Two faces of the same coin?. PIGMENT CELL RESEARCH, 16(3), 254-260.Wiley. doi: 10.1034/j.1600-0749.2003.00038.x.

Wankowicz-Kalinska, A., van den Wijngaard, R.M.J.G.J., Tigges, B.J., Westerhof, W., Ogg, G.S., Cerundolo, V., Storkus, W.J., & Das, P.K. (2003). Immunopolarization of CD4+ and CD8+ T cells to type-1-like is associated with melanocyte loss in human vitiligo. LABORATORY INVESTIGATION, 83(5), 683-695.Elsevier BV. doi: 10.1097/01.LAB.0000069521.42488.1B.

Asai, T., Storkus, W.J., Mueller-Berghaus, J., Knapp, W., DeLeo, A.B., Chikamatsu, K., & Whiteside, T.L. (2002). In vitro generated cytolytic T lymphocytes reactive against head and neckcancer recognize multiple epitopes presented by HLA-A2, including peptidesderived from the p53 and MDM-2 proteins. Cancer Immunity, 5, 1-17.

Asai, T., Storkus, W.J., Mueller-Berghaus, J., Knapp, W., DeLeo, A.B., Chikamatsu, K., & Whiteside, T.L. (2002). In vitro generated cytolytic T lymphocytes reactive against head and neck cancer recognize multiple epitopes presented by HLA-A2, including peptides derived from the p53 and MDM-2 proteins. Cancer Immun, 2, 3.

Bennouna, J., Hildesheim, A., Chikamatsu, K., Gooding, W., Storkus, W.J., & Whiteside, T.L. (2002). Application of IL-5 ELISPOT assays to quantification of antigen-specific T helper responses. JOURNAL OF IMMUNOLOGICAL METHODS, 261(1-2), 145-156.Elsevier BV. doi: 10.1016/S0022-1759(01)00566-X.

Björck, P., Lie, W.R., Woulfe, S.L., Klein, B.K., Olson, W., & Storkus, W.J. (2002). Progenipoietin-generated dendritic cells exhibit anti-tumor efficacy in a therapeutic murine tumor model. INTERNATIONAL JOURNAL OF CANCER, 100(5), 586-591.Wiley. doi: 10.1002/ijc.10529.

Bykovskaia, S.N., Shurin, G.V., Graner, S., Bunker, M.L., Olson, W., Thomas, R., Shurin, M.R., Marks, S., Storkus, W.J., & Shogan, J. (2002). Differentiation of immunostimulatory stem-cell- and monocyte-derived dendritic cells involves maturation of intracellular compartments responsible for antigen presentation and secretion. STEM CELLS, 20(5), 380-393.Oxford University Press (OUP). doi: 10.1634/stemcells.20-5-380.

Hoffmann, T.K., Müller-Berghaus, J., Ferris, R.L., Johnson, J.T., Storkus, W.J., & Whiteside, T.L. (2002). Alterations in the frequency of dendritic cell subsets in the peripheral circulation of patients with squamous cell carcinomas of the head and neck. CLINICAL CANCER RESEARCH, 8(6), 1787-1793.

Janjic, B.M., Lu, G.W., Pimenov, A., Whiteside, T.L., Storkus, W.J., & Vujanovic, N.L. (2002). Innate direct anticancer effector function of human immature dendritic cells. I. Involvement of an apoptosis-inducing pathway. JOURNAL OF IMMUNOLOGY, 168(4), 1823-1830.The American Association of Immunologists. doi: 10.4049/jimmunol.168.4.1823.

Keilholz, U., Weber, J., Finke, J.H., Gabrilovich, D.I., Kast, W.M., Disis, M.L., Kirkwood, J.M., Scheibenbogen, C., Schlom, J., Maino, V.C., Lyerly, H.K., Lee, P.P., Storkus, W., Marincola, F., Worobec, A., & Atkins, M.B. (2002). Immunologic monitoring of cancer vaccine therapy: Results of a workshop sponsored by the Society for Biological Therapy. JOURNAL OF IMMUNOTHERAPY, 25(2), 97-138.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/00002371-200203000-00001.

Lokshin, A.E., Kalinski, P., Sassi, R.R., Mailliard, R.B., Müller-Berghaus, J., Storkus, W.J., Peng, X.J., Marrangoni, A.M., Edwards, R.P., & Gorelik, E. (2002). Differential regulation of maturation and apoptosis of human monocyte-derived dendritic cells mediated by MHC class II. INTERNATIONAL IMMUNOLOGY, 14(9), 1027-1037.Oxford University Press (OUP). doi: 10.1093/intimm/dxf073.

Lotze, M.T., Mailliard, R.B., Tanaka, F., Tahara, H., Storkus, W.J., & Kalinksi, P. (2002). DC-activating function of cytokines [IL-12, IL-18], T cells and NK cells in the development of antitumor responses. CLINICAL IMMUNOLOGY, 103(3), S103-S104.

Lu, G.W., Janjic, B.M., Janjic, J., Whiteside, T.L., Storkus, W.J., & Vujanovic, N.L. (2002). Innate direct anticancer effector function of human 6 immature dendritic cells.: II.: Role of TNF, lymphotoxin-α1β2, Fas ligand, and TNF-related apoptosis-inducing ligand. JOURNAL OF IMMUNOLOGY, 168(4), 1831-1839.The American Association of Immunologists. doi: 10.4049/jimmunol.168.4.1831.

Mailliard, R.B., Egawa, S., Cai, Q., Kalinska, A., Bykovskaya, S.N., Lotze, M.T., Kapsenberg, M.L., Storkus, W.J., & Kalinski, P. (2002). Complementary dendritic cell-activating function of CD8+ and CD4+ T cells:: Helper role of CD8+ T cells in the development of T helper type 1 responses. JOURNAL OF EXPERIMENTAL MEDICINE, 195(4), 473-483.Rockefeller University Press. doi: 10.1084/jem.20011662.

Okano, F., Storkus, W.J., Chambers, W.H., Pollack, I.F., & Okada, H. (2002). Identification of a novel HLA-A*0201-restricted, cytotoxic T lymphocyte epitope in a human glioma-associated antigen, interleukin 13 receptor α2 chain. CLINICAL CANCER RESEARCH, 8(9), 2851-2855.

Tatsumi, T., & Storkus, W.J. (2002). Dendritic cell-based vaccines and therapies for cancer. EXPERT OPINION ON BIOLOGICAL THERAPY, 2(8), 919-928.Informa Healthcare. doi: 10.1517/14712598.2.8.919.

Tatsumi, T., Gambotto, A., Robbins, P.D., & Storkus, W.J. (2002). Interleukin 18 gene transfer expands the repertoire of antitumor Th1-type immunity elicited by dendritic cell-based vaccines in association with enhanced therapeutic efficacy. CANCER RESEARCH, 62(20), 5853-5858.

Tatsumi, T., Kierstead, L.S., Ranieri, E., Gesualdo, L., Schena, F.P., Finke, J.H., Bukowski, R.M., Mueller-Berghaus, J., Kirkwood, J.M., Kwok, W.W., & Storkus, W.J. (2002). Disease-associated bias in T helper type 1 (Th1)/Th2 CD4+ T cell responses against MAGE-6 in HLA-DRB1*0401+ patients with renal cell carcinoma or melanoma. JOURNAL OF EXPERIMENTAL MEDICINE, 196(5), 619-628.Rockefeller University Press. doi: 10.1084/jem.20012142.

Hoffmann, T.K., Meidenbauer, N., Müller-Berghaus, J., Storkus, W.J., & Whiteside, T.L. (2001). Proinflammatory cytokines and CD40 ligand enhance cross-presentation and cross-priming capability of human dendritic cells internalizing apoptotic cancer cells. JOURNAL OF IMMUNOTHERAPY, 24(2), 162-171.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/00002371-200103000-00011.

Hoffmann, T.K., Meidenbauer, N., Müller-Berghaus, J., Storkus, W.J., & Whiteside, T.L. (2001). Proinflammatory cytokines and CD40 ligand enhance cross-presentation and cross-priming capability of human dendritic cells internalizing apoptotic cancer cells. J Immunother, 24(2), 162-171.

Kierstead, L.S., Ranieri, E., Olson, W., Brusic, V., Sidney, J., Sette, A., Kasamon, Y.L., Slingluff, C.L., Kirkwood, J.M., & Storkus, W.J. (2001). gp100/pmel17 and tyrosinase encode multiple epitopes recognized by Th1-type CD4+T cells. BRITISH JOURNAL OF CANCER, 85(11), 1738-1745.Springer Science and Business Media LLC. doi: 10.1054/bjoc.2001.2160.

Larregina, A.T., Watkins, S.C., Erdos, G., Spencer, L.A., Storkus, W.J., Stolz, D.B., & Falo, L.D. (2001). Direct transfection and activation of human cutaneous dendritic cells. GENE THERAPY, 8(8), 608-617.Springer Science and Business Media LLC. doi: 10.1038/sj.gt.3301404.

Le, P.T., Adams, K.L., Zaya, N., Mathews, H.L., Storkus, W.J., & Ellis, T.M. (2001). Human thymic epithelial cells inhibit IL-15-and IL-2-driven differentiation of NK cells from the early human thymic progenitors. JOURNAL OF IMMUNOLOGY, 166(4), 2194-2201.The American Association of Immunologists. doi: 10.4049/jimmunol.166.4.2194.

Mailliard, R.B., Egawa, S., Cai, Q., Kalinska, A., Lotze, M.T., Kapsenberg, M.L., Storkus, W.J., & Kalinski, P. (2001). Polarized dendritic cells mediate CDS help for CD4+ T cells:: Helper function of CD8+ T cells in the development of Th1 responses. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 117(4), 1022.

Metes, D., Storkus, W.J., Zeevi, A., Watkins, S., Patterson, K., Nellis, J., Logar, A., Fung, J.J., & Rao, A.S. (2001). Use of autologous dendritic cells loaded with apoptotic LCL for ex vivo generation of specific CTL from the PBMC of EBV- individuals. TRANSPLANTATION PROCEEDINGS, 33(1-2), 441.Elsevier BV. doi: 10.1016/S0041-1345(00)02084-4.

Asai, T., Storkus, W.J., & Whiteside, T.L. (2000). Evaluation of the modified ELISPOT assay for gamma interferon production in cancer patients receiving antitumor vaccines. CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 7(2), 145-154.American Society for Microbiology. doi: 10.1128/CDLI.7.2.145-154.2000.

Dong, X., An, B., Kierstead, L.S., Storkus, W.J., Amoscato, A.A., & Salter, R.D. (2000). Modification of the amino terminus of a class II epitope confers resistance to degradation by CD13 on dendritic cells and enhances presentation to T cells. JOURNAL OF IMMUNOLOGY, 164(1), 129-135.The American Association of Immunologists. doi: 10.4049/jimmunol.164.1.129.

Herr, W., Ranieri, E., Olson, W., Zarour, H., Gesualdo, L., & Storkus, W.J. (2000). Mature dendritic cells pulsed with freeze-thaw cell lysates define an effective in vitro vaccine designed to elicit EBV-specific CD4+ and CD8+ T lymphocyte responses. BLOOD, 96(5), 1857-1864.American Society of Hematology. doi: 10.1182/blood.V96.5.1857.h8001857_1857_1864.

Lotze, M.T., Shurin, M., Esche, C., Tahara, H., Storkus, W., Kirkwood, J.M., Whiteside, T.L., Elder, E.M., Okada, H., & Robbins, P. (2000). Interleukin-2: Developing additional cytokine gene therapies using fibroblasts or dendritic cells to enhance tumor immunity. CANCER JOURNAL FROM SCIENTIFIC AMERICAN, 6(SUPPL. 1), S61-S66.

Metes, D., Storkus, W., Zeevi, A., Patterson, K., Logar, A., Rowe, D., Nalesnik, M.A., Fung, J.J., & Rao, A.S. (2000). Ex vivo generation of effective Epstein-Barr virus (EBV)-specific Cd8+ cytotoxic T lymphocytes from the peripheral blood of immunocompetent Estein Barr virus-seronegative individuals. TRANSPLANTATION, 70(10), 1507-1515.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/00007890-200011270-00019.

Ranieri, E., Kierstead, L.S., Zarour, H., Kirkwood, J.M., Lotze, M.T., Whiteside, T., & Storkus, W.J. (2000). Dendritic cell/peptide cancer vaccines: clinical responsiveness and epitope spreading. Immunol Invest, 29(2), 121-125.Informa UK Limited. doi: 10.3109/08820130009062294.

Storkus, W.J., & Zarour, H.M. (2000). Melanoma antigens recognised by CD8+ and CD4+ T cells. Forum (Genova), 10(3), 256-270.

Tüting, T., Austyn, J., Storkus, W.J., & Falo, L.D. (2000). The immunology of DNA vaccines. Methods Mol Med, 29, 37-64.Humana Press. doi: 10.1385/1-59259-688-6:37.

Zarour, H.M., Kirkwood, J.M., Kierstead, L.S., Herr, W., Brusic, V., Slingluff, C.L., Sidney, J., Sette, A., & Storkus, W.J. (2000). Melan-A/MART-151-73 represents an immunogenic HLA-DR4-restricted epitope recognized by melanoma-reactive CD4+ T cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 97(1), 400-405.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.97.1.400.

Zarour, H.M., Storkus, W.J., Brusic, V., Williams, E., & Kirkwood, J.M. (2000). NY-ESO-1 encodes DRB1*0401-restricted epitopes recognized by melanoma-reactive CD4+T cells. CANCER RESEARCH, 60(17), 4946-4952.

Chikamatsu, K., Nakano, K., Storkus, W.J., Appella, E., Lotze, M.T., Whiteside, T.L., & DeLeo, A.B. (1999). Generation of anti-p53 cytotoxic T lymphocytes from human peripheral blood using autologous dendritic cells. CLINICAL CANCER RESEARCH, 5(6), 1281-1288.

Dong, X., Storkus, W.J., & Salter, R.D. (1999). Binding and uptake of agalactosyl IgG by mannose receptor on macrophages and dendritic cells. JOURNAL OF IMMUNOLOGY, 163(10), 5427-5434.

Herr, W., Ranieri, E., Gambotto, A., Kierstead, L.S., Amoscato, A.A., Gesualdo, L., & Storkus, W.J. (1999). Identification of naturally processed and HLA-presented Epstein-Barr virus peptides recognized by CD4+ or CD8+ T lymphocytes from human blood. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 96(21), 12033-12038.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.96.21.12033.

Ranieri, E., Herr, W., Gambotto, A., Olson, W., Rowe, D., Robbins, P.D., Kierstead, L.S., Watkins, S.C., Gesualdo, L., & Storkus, W.J. (1999). Dendritic cells transduced with an adenovirus vector encoding Epstein-Barr virus latent membrane protein 2B: A new modality for vaccination. JOURNAL OF VIROLOGY, 73(12), 10416-10425.American Society for Microbiology. doi: 10.1128/JVI.73.12.10416-10425.1999.

Tüting, T., Gambotto, A., DeLeo, A., Lotze, M.T., Robbins, P.D., & Storkus, W.J. (1999). Induction of tumor antigen-specific immunity using plasmid DNA immunization in mice. CANCER GENE THERAPY, 6(1), 73-80.Springer Science and Business Media LLC. doi: 10.1038/sj.cgt.7700020.

Tüting, T., Gambotto, A., Robbins, P.D., Storkus, W.J., & DeLeo, A.B. (1999). Co-delivery of T helper 1-biasing cytokine genes enhances the efficacy of gene gun immunization of mice:: studies with the model tumor antigen β-galactosidase and the BALB/c Meth A p53 tumor-specific antigen. GENE THERAPY, 6(4), 629-636.Springer Science and Business Media LLC. doi: 10.1038/sj.gt.3300859.

Wilson, C.C., Olson, W.C., Tuting, T., Rinaldo, C.R., Lotze, M.T., & Storkus, W.J. (1999). HIV-1-specific CTL responses primed in vitro by blood-derived dendritic cells and Th1-biasing cytokines. JOURNAL OF IMMUNOLOGY, 162(5), 3070-3078.

Falo, L.D., & Storkus, W.J. (1998). Giving DNA vaccines a helping hand. NATURE MEDICINE, 4(11), 1239-1240.Springer Science and Business Media LLC. doi: 10.1038/3217.

Myers, J.N., Mank-Seymour, A., Zitvogel, L., Storkus, W., Clarke, M., Johnson, C.S., Tahara, H., & Lotze, M.T. (1998). Interleukin-12 gene therapy prevents establishment of SCC VII squamous cell carcinomas, inhibits tumor growth, and elicits long-term antitumor immunity in syngeneic C3H mice. LARYNGOSCOPE, 108(2), 261-268.Wiley. doi: 10.1097/00005537-199802000-00019.

Tjandrawan, T., Martin, D.M., Maeurer, M.J., Castelli, C., Lotze, M.T., & Storkus, W.J. (1998). Third keystone symposium on cellular immunology and the immunotherapy of cancer antigen processing and presentation autologous human dendriphages pulsed with synthetic or natural tumor peptides elicit tumor-specific CTLs in vitro. Journal of Immunotherapy, 21(2), 157-149. doi: 10.1097/00002371-199803000-00009.

Tjandrawan, T., Martin, D.M., Maeurer, M.J., Castelli, C., Lotze, M.T., & Storkus, W.J. (1998). Autologous human dendriphages pulsed with synthetic or natural tumor peptides elicit tumor-specific CTLs in vitro. JOURNAL OF IMMUNOTHERAPY, 21(2), 149-157.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/00002371-199803000-00009.

Tüting, T., Storkus, W.J., & Falo, L.D. (1998). DNA immunization targeting the skin:: Molecular control of adaptive immunity. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 111(2), 183-188.Elsevier BV. doi: 10.1046/j.1523-1747.1998.00261.x.

Tüting, T., Wilson, C.C., Martin, D.M., Baar, J., DeLeo, A., Lotze, M.T., & Storkus, W.J. (1998). DNA vaccines targeting dendritic cells for the immunotherapy of cancer. GENE THERAPY OF CANCER, 451, 295-304.Springer US. doi: 10.1007/978-1-4615-5357-1_46.

Tüting, T., Wilson, C.C., Martin, D.M., Kasamon, Y.L., Rowles, J., Ma, D.I., Slingluff, C.L., Wagner, S.N., van der Bruggen, P., Baar, J., Lotze, M.T., & Storkus, W.J. (1998). Autologous human monocyte-derived dendritic cells genetically modified to express melanoma antigens elicit primary cytotoxic T cell responses in vitro:: Enhancement by cotransfection of genes encoding the Th1-biasing cytokines IL-12 and IFN-α. JOURNAL OF IMMUNOLOGY, 160(3), 1139-1147.

Lotze, M.T., Hellerstedt, B., Stolinski, L., Tueting, T., Wilson, C., Kinzler, D., Vu, H., Rubin, J.T., Storkus, W., Tahara, H., Elder, E., & Whiteside, T. (1997). The role of interleukin-2, interleukin-12, and dendritic cells in cancer therapy. CANCER JOURNAL FROM SCIENTIFIC AMERICAN, 3(SUPPL. 1), S109-S114.

Lotze, M.T., Shurin, M., Davis, I., Amoscato, A., & Storkus, W.J. (1997). Dendritic cell based therapy of cancer. DENDRITIC CELLS IN FUNDAMENTAL AND CLINICAL IMMUNOLOGY, VOL 3, 417, 551-569.Springer US. doi: 10.1007/978-1-4757-9966-8_91.

Maeurer, M.J., Walter, W., Martin, D., Zitvogel, L., Elder, E., Storkus, W., & Lotze, M.T. (1997). Interleukin-7 (IL-7) in colorectal cancer: IL-7 is produced by tissues from colorectal cancer and promotes preferential expansion of tumour infiltrating lymphocytes. SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 45(2), 182-192.Wiley. doi: 10.1046/j.1365-3083.1997.d01-384.x.

Mayordomo, J.I., Zorina, T., Storkus, W.J., Zitvogel, L., GarciaPrats, M.D., DeLeo, A.B., & Lotze, M.T. (1997). Bone marrow-derived dendritic cells serve as potent adjuvants for peptide-based antitumor vaccines. STEM CELLS, 15(2), 94-103.Oxford University Press (OUP). doi: 10.1002/stem.150094.

Shurin, M.R., Pandharipande, P.P., Zorina, T.D., Haluszczak, C., Subbotin, V.M., Hunter, O., Brumfield, A., Storkus, W.J., Maraskovsky, E., & Lotze, M.T. (1997). FLT3 ligand induces the generation of functionally active dendritic cells in mice. CELLULAR IMMUNOLOGY, 179(2), 174-184.Elsevier BV. doi: 10.1006/cimm.1997.1152.

Tuting, T., DeLeo, A.B., Lotze, M.T., & Storkus, W.J. (1997). Genetically modified bone marrow-derived dendritic cells expressing tumor-associated viral or ''self'' antigens induce antitumor immunity in vivo. EUROPEAN JOURNAL OF IMMUNOLOGY, 27(10), 2702-2707.Wiley. doi: 10.1002/eji.1830271033.

Tuting, T., Gambotto, A., Baar, J., Davis, I.D., Storkus, W.J., Zavodny, P.J., Narula, S., Tahara, H., Robbins, P.D., & Lotze, M.T. (1997). Interferon-alpha gene therapy for cancer: retroviral transduction of fibroblasts and particle-mediated transfection of tumor cells are both effective strategies for gene delivery in murine tumor models. GENE THERAPY, 4(10), 1053-1060.Springer Science and Business Media LLC. doi: 10.1038/sj.gt.3300509.

Tuting, T., Storkus, W.J., & Lotze, M.T. (1997). Gene-based strategies for the immunotherapy of cancer. JOURNAL OF MOLECULAR MEDICINE-JMM, 75(7), 478-491.Springer Science and Business Media LLC. doi: 10.1007/s001090050133.

Amoscato, A.A., Storkus, W.J., & Lotze, M.T. (1996). Secretion of a 93 kda gelatinase by human peripheral blood dendritic cells. FASEB JOURNAL, 10(6), 2787.

Bernhard, H., Maeurer, M.J., Jager, E., Wolfel, T., Schneider, J., Karbach, J., Seliger, B., Huber, C., Storkus, W.S., Lotze, M.T., zumBuschenfelde, K.H.M., & Knuth, A. (1996). Recognition of human renal cell carcinoma and melanoma by HLA-A2-restricted cytotoxic T lymphocytes is mediated by shared peptide epitopes and up-regulated by interferon-gamma. SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 44(3), 285-292.Wiley. doi: 10.1046/j.1365-3083.1996.d01-304.x.

Celluzzi, C.M., Mayordomo, J.I., Storkus, W.J., Lotze, M.T., & Falo, L.D. (1996). Peptide-pulsed dendritic cells induce antigen-specific, CTL-mediated protective tumor immunity. JOURNAL OF EXPERIMENTAL MEDICINE, 183(1), 283-287.Rockefeller University Press. doi: 10.1084/jem.183.1.283.

Galon, J., Gauchat, J.F., Mazieres, N., Spagnoli, R., Storkus, W., Lotze, M., Bonnefoy, J.Y., Fridman, W.H., & Sautes, C. (1996). Soluble Fc gamma receptor type III (Fc gamma RIII, CD16) triggers cell activation through interaction with complement receptors. JOURNAL OF IMMUNOLOGY, 157(3), 1184-1192.

Lotze, M.T., Zitvogel, L., Campbell, R., Robbins, P.D., Elder, E., Haluszczak, C., Martin, D., Whiteside, T.L., Storkus, W.J., & Tahara, H. (1996). Cytokine gene therapy of cancer using interleukin-12: Murine and clinical trials. INERLEUKIN 12: CELLULAR AND MOLECULAR IMMUNOLOGY OF AN IMPORTANT REGULATORY CYTOKINE, 795(1), 440-454.Wiley. doi: 10.1111/j.1749-6632.1996.tb52715.x.

Maeurer, M.J., Chan, H.W., Karbach, J., Salter, R.D., Knuth, A., Lotze, M.T., & Storkus, W.J. (1996). Amino acid substitutions at position 97 in HLA-A2 segregate cytolysis from cytokine release in MART-1/Melan-A peptide AAGIGILTV-specific cytotoxic T lymphocytes. EUROPEAN JOURNAL OF IMMUNOLOGY, 26(11), 2613-2623.Wiley. doi: 10.1002/eji.1830261112.

Maeurer, M.J., Gollin, S.M., Martin, D., Swaney, W., Bryant, J., Castelli, C., Robbins, P., Parmiani, G., Storkus, W.J., & Lotze, M.T. (1996). Tumor escape from immune recognition - Lethal recurrent melanoma in a patient associated with downregulation of the peptide transporter protein TAP-1 and loss of expression of the immunodominant MART-1/Melan-A antigen. JOURNAL OF CLINICAL INVESTIGATION, 98(7), 1633-1641.American Society for Clinical Investigation. doi: 10.1172/JCI118958.

Maeurer, M.J., Gollin, S.M., Storkus, W.J., Swaney, W., Karbach, J., Martin, D., Castelli, C., Salter, R., Knuth, A., & Lotze, M.T. (1996). Tumor escape from immune recognition: Loss of HLA-A2 melanoma cell surface expression is associated with a complex rearrangement of the short arm of chromosome 6(1). CLINICAL CANCER RESEARCH, 2(4), 641-652.

Maeurer, M.J., Martin, D., Elder, E., Storkus, W.J., & Lotze, M.T. (1996). Detection of naturally processed and HLA-A1-presented melanoma T-cell epitopes defined by CD8(+) T-cells' release of granulocyte-macrophage colony-stimulating factor but not by cytolysis. CLINICAL CANCER RESEARCH, 2(1), 87-95.

Maeurer, M.J., Martin, D., Walter, W., Liu, K.H., Zitvogel, L., Halusczcak, K., Rabinowich, H., Duquesnoy, R., Storkus, W., & Lotze, M.T. (1996). Human intestinal V delta 1(+) T lymphocytes recognize tumor cells of epithelial origin. JOURNAL OF EXPERIMENTAL MEDICINE, 183(4), 1681-1696.Rockefeller University Press. doi: 10.1084/jem.183.4.1681.

Maeurer, M.J., Storkus, W.J., Kirkwood, J.M., & Lotze, M.T. (1996). New treatment options for patients with melanoma: Review of melanoma-derived T-cell epitope-based peptide vaccines. MELANOMA RESEARCH, 6(1), 11-24.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/00008390-199602000-00003.

Mayordomo, J.I., Loftus, D.J., Sakamoto, H., DeCesare, C.M., Appasamy, P.M., Lotze, M.T., Storkus, W.J., Appella, E., & DeLeo, A.B. (1996). Therapy of murine tumors with p53 wild-type and mutant sequence peptide-based vaccines. JOURNAL OF EXPERIMENTAL MEDICINE, 183(4), 1357-1365.Rockefeller University Press. doi: 10.1084/jem.183.4.1357.

Mazzocchi, A., Storkus, W.J., Traversari, C., Tarsini, P., Maeurer, M.J., Rivoltini, L., Vegetti, C., Belli, F., Anichini, A., Parmiani, G., & Castelli, C. (1996). Multiple melanoma-associated epitopes recognized by HLA-A3-restricted CTLs and shared by melanomas but not melanocytes. JOURNAL OF IMMUNOLOGY, 157(7), 3030-3038.

Storkus, W.J., Wei, M., Cresswell, P., & Dawson, J.R. (1996). Class I-like CD1A-C do not protect target cells from NK-mediated cytolysis. CELLULAR IMMUNOLOGY, 167(1), 154-156.Elsevier BV. doi: 10.1006/cimm.1996.0020.

Storkus, W.J., Zitvogel, L., Tueting, T., Couderc, B.C., Baar, J., Rowles, J., Tjandrawan, T., Robbins, P.D., Wilson, C.C., Ma, D.I., Edington, H.D., & Lotze, M.T. (1996). Genetically-modified dendritic cells serve as effective adjuvants in promoting anti-tumor immunity in vitro and in vivo. FASEB JOURNAL, 10(6), 2551.

Tahara, H., Zitvogel, L., Storkus, W.J., Robbins, P.D., & Lotze, M.T. (1996). Murine models of cancer cytokine gene therapy using interleukin-12. INERLEUKIN 12: CELLULAR AND MOLECULAR IMMUNOLOGY OF AN IMPORTANT REGULATORY CYTOKINE, 795(1), 275-283.Wiley. doi: 10.1111/j.1749-6632.1996.tb52677.x.

Zitvogel, L., Couderc, B., Mayordomo, J.I., Robbins, P.D., Lotze, M.T., & Storkus, W.J. (1996). IL-12-engineered dendritic cells serve as effective tumor vaccine adjuvants in vivo. INERLEUKIN 12: CELLULAR AND MOLECULAR IMMUNOLOGY OF AN IMPORTANT REGULATORY CYTOKINE, 795(1), 284-293.Wiley. doi: 10.1111/j.1749-6632.1996.tb52678.x.

Zitvogel, L., Mayordomo, J.I., Tjandrawan, T., DeLeo, A.B., Clarke, M.R., Lotze, M.T., & Storkus, W.J. (1996). Therapy of murine tumors with tumor peptide-pulsed dendritic cells: Dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines. JOURNAL OF EXPERIMENTAL MEDICINE, 183(1), 87-97.Rockefeller University Press. doi: 10.1084/jem.183.1.87.

Zitvogel, L., Robbins, P.D., Storkus, W.J., Clarke, M.R., Maeurer, M.J., Campbell, R.L., Davis, C.G., Tahara, H., Schreiber, R.D., & Lotze, M.T. (1996). Interleukin-12 and B7.1 co-stimulation cooperate in the induction of effective antitumor immunity and therapy of established tumors. EUROPEAN JOURNAL OF IMMUNOLOGY, 26(6), 1335-1341.Wiley. doi: 10.1002/eji.1830260624.

CASTELLI, C., STORKUS, W.J., MAEURER, M.J., MARTIN, D.M., HUANG, E.C., PRAMANIK, B.N., NAGABHUSHAN, T.L., PARMIANI, G., & LOTZE, M.T. (1995). MASS-SPECTROMETRIC IDENTIFICATION OF A NATURALLY PROCESSED MELANOMA PEPTIDE RECOGNIZED BY CD8(+) CYTOTOXIC T-LYMPHOCYTES. JOURNAL OF EXPERIMENTAL MEDICINE, 181(1), 363-368.Rockefeller University Press. doi: 10.1084/jem.181.1.363.

FRASSANITO, M.A., MAYORDOMO, J.I., DELEO, R.M., STORKUS, W.J., LOTZE, M.T., & DELEO, A.B. (1995). IDENTIFICATION OF METH-A SARCOMA-DERIVED CLASS-I MAJOR HISTOCOMPATIBILITY COMPLEX-ASSOCIATED PEPTIDES RECOGNIZED BY A SPECIFIC CD8(+) CYTOTOXIC T-LYMPHOCYTE. CANCER RESEARCH, 55(1), 124-128.

Maeurer, M., Zitvogel, L., Elder, E., Storkus, W.J., & Lotze, M.T. (1995). Human intestinal V(delta)1+T cells obtained from patients with colon cancer respond exclusively to SEB but not to SEA. NATURAL IMMUNITY, 14(4), 188-197.

Maeurer, M.J., Hurd, S., Martin, D.M., Storkus, W.J., & Lotze, M.T. (1995). Cytolytic T-cell clones define HLA-A2-restricted human cutaneous melanoma peptide epitopes: correlation with T-cell receptor usage. Cancer J Sci Am, 1(2), 162-170.

MAEURER, M.J., MARTIN, D.M., CASTELLI, C., ELDER, E., LEDER, G., STORKUS, W.J., & LOTZE, M.T. (1995). HOST IMMUNE-RESPONSE IN RENAL-CELL CANCER - INTERLEUKIN-4 (IL-4) AND IL-10 MESSENGER-RNA ARE FREQUENTLY DETECTED IN FRESHLY COLLECTED TUMOR-INFILTRATING LYMPHOCYTES. CANCER IMMUNOLOGY IMMUNOTHERAPY, 41(2), 111-121.Springer Science and Business Media LLC. doi: 10.1007/BF01527407.

MAEURER, M.J., MARTIN, D.M., STORKUS, W.J., & LOTZE, M.T. (1995). TCR USAGE IN CTLS RECOGNIZING MELANOMA MELANOCYTE ANTIGENS. IMMUNOLOGY TODAY, 16(12), 603-604.Elsevier BV. doi: 10.1016/0167-5699(95)80084-0.

MAYORDOMO, J.I., ZORINA, T., STORKUS, W.J., ZITVOGEL, L., CELLUZZI, C., FALO, L.D., MELIEF, C.J., ILDSTAD, S.T., KAST, W.M., DELEO, A.B., & LOTZE, M.T. (1995). BONE-MARROW-DERIVED DENDRITIC CELLS PULSED WITH SYNTHETIC TUMOR PEPTIDES ELICIT PROTECTIVE AND THERAPEUTIC ANTITUMOR IMMUNITY. NATURE MEDICINE, 1(12), 1297-1302.Springer Science and Business Media LLC. doi: 10.1038/nm1295-1297.

Tahara, H., Lotze, M., Robbins, P.D., Storkus, W.J., & Zitvogel, L. (1995). IL-12 gene therapy using direct injection of tumors with genetically engineered autologous fibroblasts. HUMAN GENE THERAPY, 6(12), 1607-1624.Mary Ann Liebert Inc. doi: 10.1089/hum.1995.6.12-1607.

TAHARA, H., ZITVOGEL, L., STORKUS, W.J., ZEH, H.J., MCKINNEY, T.G., SCHREIBER, R.D., GUBLER, U., ROBBINS, P.D., & LOTZE, M.T. (1995). EFFECTIVE ERADICATION OF ESTABLISHED MURINE TUMORS WITH IL-12 GENE-THERAPY USING A POLYCISTRONIC RETROVIRAL VECTOR. JOURNAL OF IMMUNOLOGY, 154(12), 6466-6474.

ZITVOGEL, L., TAHARA, H., ROBBINS, P.D., STORKUS, W.J., CLARKE, M.R., NALESNIK, M.A., & LOTZE, M.T. (1995). CANCER-IMMUNOTHERAPY OF ESTABLISHED TUMORS WITH IL-12 - EFFECTIVE DELIVERY BY GENETICALLY-ENGINEERED FIBROBLASTS. JOURNAL OF IMMUNOLOGY, 155(3), 1393-1403.

ITOH, T., STORKUS, W.J., GORELIK, E., & LOTZE, M.T. (1994). PARTIAL-PURIFICATION OF MURINE TUMOR-ASSOCIATED PEPTIDE EPITOPES COMMON TO HISTOLOGICALLY DISTINCT TUMORS, MELANOMA AND SARCOMA, THAT ARE PRESENTED BY H-2K(B) MOLECULES AND RECOGNIZED BY CD8+ TUMOR-INFILTRATING LYMPHOCYTES. JOURNAL OF IMMUNOLOGY, 153(3), 1202-1215.

Leder, G.H., Storkus, W.J., Stuber, G., Modrow, S., & Lotze, M.T. (1994). Erratum: (Langenbecks Archiv fur Chirurgie, Forumband 1994). Langenbecks Archiv fur Chirurgie, 379(4), 254.

NASTALA, C.L., EDINGTON, H.D., MCKINNEY, T.G., TAHARA, H., NALESNIK, M.A., BRUNDA, M.J., GATELY, M.K., WOLF, S.F., SCHREIBER, R.D., STORKUS, W.J., & LOTZE, M.T. (1994). RECOMBINANT IL-12 ADMINISTRATION INDUCES TUMOR-REGRESSION IN ASSOCIATION WITH IFN-GAMMA PRODUCTION. JOURNAL OF IMMUNOLOGY, 153(4), 1697-1706.

STUBER, G., LEDER, G.H., STORKUS, W.J., LOTZE, M.T., MODROW, S., SZEKELY, L., WOLF, H., KLEIN, E., KARRE, K., & KLEIN, G. (1994). IDENTIFICATION OF WILD-TYPE AND MUTANT P53 PEPTIDES BINDING TO HLA-A2 ASSESSED BY A PEPTIDE LOADING-DEFICIENT CELL-LINE ASSAY AND A NOVEL MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I PEPTIDE BINDING ASSAY. EUROPEAN JOURNAL OF IMMUNOLOGY, 24(3), 765-768.Wiley. doi: 10.1002/eji.1830240341.

TAHARA, H., ZEH, H.J., STORKUS, W.J., PAPPO, I., WATKINS, S.C., GUBLER, U., WOLF, S.F., ROBBINS, P.D., & LOTZE, M.T. (1994). FIBROBLASTS GENETICALLY-ENGINEERED TO SECRETE INTERLEUKIN-12 CAN SUPPRESS TUMOR-GROWTH AND INDUCE ANTITUMOR IMMUNITY TO A MURINE MELANOMA IN-VIVO. CANCER RESEARCH, 54(1), 182-189.

ZEH, H.J., LEDER, G.H., LOTZE, M.T., SALTER, R.D., TECTOR, M., STUBER, G., MODROW, S., & STORKUS, W.J. (1994). FLOW-CYTOMETRIC DETERMINATION OF PEPTIDE CLASS-I COMPLEX-FORMATION - IDENTIFICATION OF P53 PEPTIDES THAT BIND TO HLA-A2. HUMAN IMMUNOLOGY, 39(2), 79-86.Elsevier BV. doi: 10.1016/0198-8859(94)90105-8.

ZITVOGEL, L., TAHARA, H., CAI, Q., STORKUS, W.J., MULLER, G., WOLF, S.F., GATELY, M., ROBBINS, P.D., & LOTZE, M.T. (1994). CONSTRUCTION AND CHARACTERIZATION OF RETROVIRAL VECTORS EXPRESSING BIOLOGICALLY-ACTIVE HUMAN INTERLEUKIN-12. HUMAN GENE THERAPY, 5(12), 1493-1506.Mary Ann Liebert Inc. doi: 10.1089/hum.1994.5.12-1493.

STORKUS, W.J., ZEH, H.J., MAEURER, M.J., SALTER, R.D., & LOTZE, M.T. (1993). IDENTIFICATION OF HUMAN-MELANOMA PEPTIDES RECOGNIZED BY CLASS-I RESTRICTED TUMOR-INFILTRATING T-LYMPHOCYTES. JOURNAL OF IMMUNOLOGY, 151(7), 3719-3727.

STORKUS, W.J., ZEH, H.J., SALTER, R.D., & LOTZE, M.T. (1993). IDENTIFICATION OF T-CELL EPITOPES - RAPID ISOLATION OF CLASS-I - PRESENTED PEPTIDES FROM VIABLE CELLS BY MILD ACID ELUTION. JOURNAL OF IMMUNOTHERAPY, 14(2), 94-103.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/00002371-199308000-00003.

ZEH, H.J., HURD, S., STORKUS, W.J., & LOTZE, M.T. (1993). INTERLEUKIN-12 PROMOTES THE PROLIFERATION AND CYTOLYTIC MATURATION OF IMMUNE EFFECTORS - IMPLICATIONS FOR THE IMMUNOTHERAPY OF CANCER. JOURNAL OF IMMUNOTHERAPY, 14(2), 155-161.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/00002371-199308000-00012.

STORKUS, W.J., SALTER, R.D., CRESSWELL, P., & DAWSON, J.R. (1992). PEPTIDE-INDUCED MODULATION OF TARGET-CELL SENSITIVITY TO NATURAL KILLING. JOURNAL OF IMMUNOLOGY, 149(4), 1185-1190.

STORKUS, W.J., & DAWSON, J.R. (1991). TARGET STRUCTURES INVOLVED IN NATURAL KILLING (NK) - CHARACTERISTICS, DISTRIBUTION, AND CANDIDATE MOLECULES. CRITICAL REVIEWS IN IMMUNOLOGY, 10(5), 393-416.

STORKUS, W.J., SALTER, R.D., ALEXANDER, J., WARD, F.E., RUIZ, R.E., CRESSWELL, P., & DAWSON, J.R. (1991). CLASS-I-INDUCED RESISTANCE TO NATURAL KILLING - IDENTIFICATION OF NONPERMISSIVE RESIDUES IN HLA-A2. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 88(14), 5989-5992.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.88.14.5989.

MILLER, M.F., MITCHELL, T.G., STORKUS, W.J., & DAWSON, J.R. (1990). HUMAN NATURAL-KILLER-CELLS DO NOT INHIBIT GROWTH OF CRYPTOCOCCUS-NEOFORMANS IN THE ABSENCE OF ANTIBODY. INFECTION AND IMMUNITY, 58(3), 639-645.American Society for Microbiology. doi: 10.1128/IAI.58.3.639-645.1990.

Storkus, W.J., Alexander, J., Payne, J.A., Cresswell, P., & Dawson, J.R. (1989). The α1/α2 domains of class I HLA molecules confer resistance to natural killing. Journal of Immunology, 143(11), 3853-3857.

STORKUS, W.J., ALEXANDER, J., PAYNE, J.A., CRESSWELL, P., & DAWSON, J.R. (1989). THE ALPHA-1 ALPHA-2 DOMAINS OF CLASS-I HLA MOLECULES CONFER RESISTANCE TO NATURAL KILLING. JOURNAL OF IMMUNOLOGY, 143(11), 3853-3857.

STORKUS, W.J., ALEXANDER, J., PAYNE, J.A., DAWSON, J.R., & CRESSWELL, P. (1989). REVERSAL OF NATURAL KILLING SUSCEPTIBILITY IN TARGET-CELLS EXPRESSING TRANSFECTED CLASS-I HLA GENES. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 86(7), 2361-2364.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.86.7.2361.

STORKUS, W.J., HOWELL, D.N., SALTER, R.D., DAWSON, J.R., & CRESSWELL, P. (1987). NK SUSCEPTIBILITY VARIES INVERSELY WITH TARGET-CELL CLASS-I HLA-ANTIGEN EXPRESSION. JOURNAL OF IMMUNOLOGY, 138(6), 1657-1659.

STORKUS, W.J., & DAWSON, J.R. (1986). B-CELL SENSITIVITY TO NATURAL KILLING - CORRELATION WITH TARGET-CELL STAGE OF DIFFERENTIATION AND STATE OF ACTIVATION. JOURNAL OF IMMUNOLOGY, 136(5), 1542-1547.

STORKUS, W.J., & DAWSON, J.R. (1986). OXYGEN-REACTIVE METABOLITES ARE NOT DETECTED AT THE EFFECTOR-TARGET INTERFACE DURING NATURAL KILLING. JOURNAL OF LEUKOCYTE BIOLOGY, 39(5), 547-557.Oxford University Press (OUP). doi: 10.1002/jlb.39.5.547.

STORKUS, W.J., BALBER, A.E., & DAWSON, J.R. (1986). QUANTITATION AND SORTING OF VITALLY STAINED NATURAL-KILLER CELL-TARGET CELL CONJUGATES BY DUAL BEAM FLOW-CYTOMETRY. CYTOMETRY, 7(2), 163-170.Wiley. doi: 10.1002/cyto.990070207.

Maurer, D.M., Adamik, J., Santos, P.M., Shi, J., Shurin, M.R., Kirkwood, J.M., Storkus, W.J., & Butterfield, L.H. Supplementary Figure legends from Dysregulated NF-κB–Dependent ICOSL Expression in Human Dendritic Cell Vaccines Impairs T-cell Responses in Patients with Melanoma. American Association for Cancer Research (AACR). doi: 10.1158/2326-6066.22542652.

Maurer, D.M., Adamik, J., Santos, P.M., Shi, J., Shurin, M.R., Kirkwood, J.M., Storkus, W.J., & Butterfield, L.H. Supplementary Tables 1-2 from Dysregulated NF-κB–Dependent ICOSL Expression in Human Dendritic Cell Vaccines Impairs T-cell Responses in Patients with Melanoma. American Association for Cancer Research (AACR). doi: 10.1158/2326-6066.22542640.

Maurer, D.M., Adamik, J., Santos, P.M., Shi, J., Shurin, M.R., Kirkwood, J.M., Storkus, W.J., & Butterfield, L.H. Data from Dysregulated NF-κB–Dependent ICOSL Expression in Human Dendritic Cell Vaccines Impairs T-cell Responses in Patients with Melanoma. American Association for Cancer Research (AACR). doi: 10.1158/2326-6066.c.6550006.v1.

Maurer, D.M., Adamik, J., Santos, P.M., Shi, J., Shurin, M.R., Kirkwood, J.M., Storkus, W.J., & Butterfield, L.H. Supplementary Tables 1-2 from Dysregulated NF-κB–Dependent ICOSL Expression in Human Dendritic Cell Vaccines Impairs T-cell Responses in Patients with Melanoma. American Association for Cancer Research (AACR). doi: 10.1158/2326-6066.22542640.v1.

Maurer, D.M., Adamik, J., Santos, P.M., Shi, J., Shurin, M.R., Kirkwood, J.M., Storkus, W.J., & Butterfield, L.H. Supplementary Figures 1-6 from Dysregulated NF-κB–Dependent ICOSL Expression in Human Dendritic Cell Vaccines Impairs T-cell Responses in Patients with Melanoma. American Association for Cancer Research (AACR). doi: 10.1158/2326-6066.22542649.

Maurer, D.M., Adamik, J., Santos, P.M., Shi, J., Shurin, M.R., Kirkwood, J.M., Storkus, W.J., & Butterfield, L.H. Supplementary Figures 1-6 from Dysregulated NF-κB–Dependent ICOSL Expression in Human Dendritic Cell Vaccines Impairs T-cell Responses in Patients with Melanoma. American Association for Cancer Research (AACR). doi: 10.1158/2326-6066.22542649.v1.

Maurer, D.M., Adamik, J., Santos, P.M., Shi, J., Shurin, M.R., Kirkwood, J.M., Storkus, W.J., & Butterfield, L.H. Supplementary Figure legends from Dysregulated NF-κB–Dependent ICOSL Expression in Human Dendritic Cell Vaccines Impairs T-cell Responses in Patients with Melanoma. American Association for Cancer Research (AACR). doi: 10.1158/2326-6066.22542652.v1.

Maurer, D.M., Adamik, J., Santos, P.M., Shi, J., Shurin, M.R., Kirkwood, J.M., Storkus, W.J., & Butterfield, L.H. Data from Dysregulated NF-κB–Dependent ICOSL Expression in Human Dendritic Cell Vaccines Impairs T-cell Responses in Patients with Melanoma. American Association for Cancer Research (AACR). doi: 10.1158/2326-6066.c.6550006.

Maurer, D.M., Adamik, J., Santos, P.M., Shi, J., Shurin, M.R., Kirkwood, J.M., Storkus, W.J., & Butterfield, L.H. Supplementary Table legends from Dysregulated NF-κB–Dependent ICOSL Expression in Human Dendritic Cell Vaccines Impairs T-cell Responses in Patients with Melanoma. American Association for Cancer Research (AACR). doi: 10.1158/2326-6066.22542646.

Maurer, D.M., Adamik, J., Santos, P.M., Shi, J., Shurin, M.R., Kirkwood, J.M., Storkus, W.J., & Butterfield, L.H. Supplementary Table legends from Dysregulated NF-κB–Dependent ICOSL Expression in Human Dendritic Cell Vaccines Impairs T-cell Responses in Patients with Melanoma. American Association for Cancer Research (AACR). doi: 10.1158/2326-6066.22542646.v1.

Karapetyan, L., Gooding, W., Yang, X., Knight, A., Li, A., Sander, C., Panelli, M., Storkus, W.J., Tarhini, A.A., & Kirkwood, J.M. (2022). Sentinel lymph node gene expression signature predicts survival outcome in cutaneous melanoma. In CANCER RESEARCH, 82(12).

Karapetyan, L., Gooding, W., Yang, X., Knight, A., Li, A., Sander, C., Panelli, M., Storkus, W.J., Tarhini, A.A., & Kirkwood, J.M. (2022). Sentinel lymph node gene expression signature predicts survival outcome in cutaneous melanoma. In CANCER RESEARCH, 82(12).

Filderman, J., Chelvanambi, M., & Storkus, W.J. (2021). STING agonism combined with arginase and PTGES/COX2 inhibitors for improved anti -tumor immunotherapeutic benefit. In JOURNAL OF IMMUNOLOGY, 206.

III, F.L.D., Hao, X., Chen, G., Carey, C.D., Liu, Z., Bartlett, D., Storkus, W.J., Jr, F.L.D., & You, Z. (2021). PD1 Blockade of Tumor-primed CD4 T Cells Instigates Protective Immunity Against Tumor Rechallenge. In JOURNAL OF IMMUNOLOGY, 206.

Karapetyan, L., Yang, X., Wang, H., Sander, C., Karunamurthy, A., Kirkwood, J.M., & Storkus, W.J. (2021). Serum multiplex analysis of tertiary lymphoid structure-associated chemokines/cytokines in melanoma patients. In CANCER RESEARCH, 81(13).

Hwang, M.P., Fecek, R.J., Qin, T.M., Storkus, W., & Wang, Y. (2019). Heparin-based il-12 complex coacervate inhibits B16F10 melanoma tumor progression. In Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, 40, (p. 342).

Razzo, B.M., Hong, C.S., Fabian, K.P., Ludwig, N., Sharma, P., Storkus, W.J., & Whiteside, T.L. (2018). Head and neck cancer-derived exosomes facilitate carcinogenesis in the murine 4NQO chemically induced oropharyngeal cancer. In CANCER RESEARCH, 78(13), (p. 1748).American Association for Cancer Research (AACR). doi: 10.1158/1538-7445.AM2018-1748.

Weinstein, A.M., Chen, L., Giraldo, N., Petitprez, F., Lacroix, L., Brzana, E.A., Fridman, W.H., Sautes-Fridman, C., & Storkus, W.J. (2018). IL-36γ promotes a local immune response via the formation of tertiary lymphoid structures in colorectal carcinoma. In JOURNAL OF IMMUNOLOGY, 200(1).

Weinstein, A.M., Giraldo, N.A., Julie, C., Lacroix, L., Petitprez, F., Emile, J.F., Fridman, W.H., Storkus, W.J., & Sautes-Fridman, C. (2017). Expression pattern and prognostic value of IL-36g in colorectal cancer. In JOURNAL FOR IMMUNOTHERAPY OF CANCER, 5.

Raveendran, S., Fecek, R., Carey, C.D., & Storkus, W.J. (2016). Combination immunotherapy targeting HSP90 DNA -repair client proteins overexpressed in chemotherapy -resistant melanoma. In CANCER RESEARCH, 76.

Weinstein, A.M., Chen, L., & Storkus, W.J. (2016). Modulation of tumor vasculature promotes tertiary lymphoid organogenesis. In JOURNAL OF IMMUNOLOGY, 196.

Lowe, D.B., Bose, A., & Storkus, W.J. (2012). Combined vaccine plus axitinib therapy yields superior anti-tumor efficacy in a murine melanoma model. In JOURNAL OF INVESTIGATIVE DERMATOLOGY, 132, (p. S104).

Rao, A., Kawabe, M., & Storkus, W.J. (2012). Immunostimulatory effects of HSP90 inhibition: Insights from combinational immunotherapies targeting EphA2. In CANCER RESEARCH, 72(8_Supplement), (p. 4399).American Association for Cancer Research (AACR). doi: 10.1158/1538-7445.AM2012-4399.

Sabins, N.C., Bose, A., & Storkus, W.J. (2012). Tumor Pericytes: A Novel Target for Immunotherapy in Renal Cell Carcinoma. In MOLECULAR THERAPY, 20, (p. S130).

Taylor, J.L., Qu, Y., Chen, L., Lowe, D.B., & Storkus, W.J. (2012). Combined Tbet and IL-12 gene therapy elicits and recruits superior anti-tumor immunity in vivo. In CANCER RESEARCH, 72(8_Supplement), (p. 1537).American Association for Cancer Research (AACR). doi: 10.1158/1538-7445.AM2012-1537.

Vujanovic, L., Kirkwood, J.M., Storkus, W.J., & Butterfield, L.H. (2012). Induction of MAGE-A6-Specific CD8+T-cell Responses Using MAGE-A6 and Mycoplasma Penetrans HF-2 Permease-derived Peptides. In JOURNAL OF IMMUNOTHERAPY, 35(9), (p. 746).

Rao, P., Kawabe, M., & Storkus, W.J. (2011). Integration of 17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG) in combinational immunotherapy targeting tumor antigen EphA2. In CANCER RESEARCH, 71(8_Supplement), (p. 1805).American Association for Cancer Research (AACR). doi: 10.1158/1538-7445.AM2011-1805.

Pardee, A.D., Epstein, A.L., & Storkus, W.J. (2010). A novel OX40 agonist licenses systemic anti-tumor immunity to overcome local immune suppression induced by well-established tumors. In CANCER RESEARCH, 70(8_Supplement), (p. 2938).American Association for Cancer Research (AACR). doi: 10.1158/1538-7445.AM10-2938.

Komita, H., Amoscato, A.A., Alber, S.M., Wesa, A.K., & Storkus, W.J. (2008). Hemoglobin-beta as a Tumor-rejection Antigen Allowing Immune Targeting of the Tumor-associated Stroma. In JOURNAL OF IMMUNOTHERAPY, 31(9), (p. 965).

Pardee, A.D., Epstein, A.L., Alber, S., Watkins, S.C., Wesa, A.K., & Storkus, W.J. (2008). Late-stage Tumors are Enriched in T Cells Bearing a GITRHI/OX40+ Phenotype and are Effectively Treated With GITR and OX40 Agonists. In JOURNAL OF IMMUNOTHERAPY, 31(9), (p. 933).

Scholnicoff, E.T., Wesa, A., & Storkus, W.J. (2008). Indoleamine 2,3-dioxygenase Expression in Renal Cell Carcinoma. In JOURNAL OF IMMUNOTHERAPY, 31(9), (p. 967).

Komita, H., & Storkus, W.J. (2007). Dendritic cells engineered to secrete interleukin-12 P70 when delivered into tumors results in the crosspriming of an expanded anti-tumor CD8+ T cell repertoire and therapeutic benefit. In JOURNAL OF IMMUNOTHERAPY, 30(8), (p. 896).

Komita, H., Mandic, M., Kawabe, M., & Storkus, W.J. (2007). RTK-based vaccines elicit specific CD8+T cell responses in HLA-A2 transgenic mice. In JOURNAL OF IMMUNOLOGY, 178.

Mandic, M., Kawabe, M., Vasquez, A.C., & Storkus, W.J. (2007). Conditional triggering of EphA2 epitope presentation results in the enhanced tumor cell recognition by specific CTL. In JOURNAL OF IMMUNOLOGY, 178.

Wesa, A.K., Kirkwood, J.M., Kwok, W.W., & Storkus, W.J. (2007). Apoptosis of circulating tumor-antigen specific TH1 CD4+ T cells from melanoma patients. In JOURNAL OF IMMUNOTHERAPY, 30(8), (p. 866).

Kalinski, P., Mailliard, R., Geskin, L., Giermasz, A., Nakamura, Y., Watchmaker, P., Muthuswamy, R., Storkus, W.J., Bartlett, D., Edington, H., Jr, F.L.D., & Kirkwood, J.M. (2006). Polarized DCs as therapeutic cancer vaccines. In CANCER RESEARCH, 66(8).

Kuwashima, N., Nishimura, F., Eguchi, J., Sato, H., Hatano, M., Tsugawa, T., Sakaida, T., Dusak, J.E., Fellows-Mayle, W.K., Papworth, G.D., Watkins, S.C., Gambotto, A., Pollack, I.F., Storkus, W.J., Okada, H., & Yanaga, K. (2006). Delivery of dendritic cells engineered to secrete IFN-alpha into central nervous system tumors enhances the efficacy of peripheral tumor cell vaccines: Dependence on apoptotic pathways. In JOURNAL OF GENE MEDICINE, 8(12), (p. 1449).

Sasaki, K., Zhu, X., Fujita, M., Nishimura, F., Dusak, J.E., Storkus, W.J., & Okada, H. (2006). Preferential expression of VLA-4 on Tc1 cells plays a critical role in trafficking into central nervous system tumors. In NEURO-ONCOLOGY, 8(4), (p. 430).

Storkus, W.J., Watkins, S.C., Huang, J., & Berhanu, A. (2006). Treatment-enhanced CD4+Foxp3+GITRHi T cells limit the effectiveness of cytokine-based immunotherapy. In JOURNAL OF IMMUNOLOGY, 176, (p. S276).

Wesa, A., Mandic, M., Kirkwood, J.M., Kwok, W., & Storkus, W.J. (2006). Circulating tumor-antigen specific CD4 T cells in melanoma patients have a pro-apoptotic phenotype. In JOURNAL OF INVESTIGATIVE DERMATOLOGY, 126, (p. 123).

Yamaguchi, S., Tatsumi, T., Takehara, T., Sasakawa, A., Fujita, Y., Sakamori, R., Uemura, A., Kohga, K., Ohkawa, K., Hiramatsu, N., Kanto, T., Storkus, W.J., & Hayashi, N. (2006). Efficacy of immunotherapy with the receptor tyrosine kinase EPHA2 derived peptides-pulsed dendritic cells in mouse liver tumor. In HEPATOLOGY, 44(4), (p. 524A).

Huang, J., & Storkus, W.J. (2005). Sensitization of tumor cells to dendritic cell-mediated apoptosis by nitric oxide via a Fas-dependent pathway. In FASEB JOURNAL, 19(4), (p. A413).

Wesa, A., Kalinski, P., Kirkwood, J.M., & Storkus, W.J. (2005). Rescuing anti-melanoma CD4+ responses with type-1 polarized dendritic cells: Essential roles of extended IL-12 family members. In JOURNAL OF IMMUNOTHERAPY, 28(6), (p. 661).Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/01.cji.0000191105.81066.35.

Finke, J.H., Tannenbaum, C., Storkus, W., Rayman, P., Das, T., Biswas, K., Richmond, A., Moon, C., Thornton, M., Gill, I., Novick, A., & Bukowski, R. (2004). Tumor-induced dysfunction in T lymphocytes: increased sensitivity to apoptosis. In UROLOGE A, 43(S3), (pp. S131-S132).Springer Science and Business Media LLC.Germany. doi: 10.1007/s00120-004-0600-z.

Hatano, M., Tatsumi, T., Kuwashima, N., Dusak, J.E., Pollack, I.F., Storkus, W.J., & Okada, H. (2004). As a glioma/angiogenesis-associated antigen: A target for novel glioma immunotherapy strategies. In NEURO-ONCOLOGY, 6(4), (p. 342).

Lotze, M.T., Tahara, H., Storkus, W.J., Whiteside, T.L., Hall, T., Kinzler, D., & Zeh, H.J. (2004). Ten year experience and followup of effective gene therapy in patients with cancer. In ANNALS OF SURGICAL ONCOLOGY, 11(2), (pp. S78-S79).Springer Science and Business Media LLC. doi: 10.1007/BF02524058.

Wesa, A., Kalinski, P., John, M.K., & Storkus, W.J. (2004). Restoration of TH1 CD4+ T cell responses to melanoma antigens with type-1 polarized dendritic cells. In JOURNAL OF IMMUNOTHERAPY, 27(6), (p. S34).Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/00002371-200411000-00124.

Zarour, H.M., Land, S., Sander, C., Mascari, R., Storkus, W.J., Shipe-Spotloe, J., Stover, L., Herberman, R.B., Agarwala, S.S., & Kirkwood, J.M. (2004). Phase I-II vaccine trial with MHC class II and MHC class I epitopes from melan-A/MART-1 for patients with metastatic melanoma. In JOURNAL OF CLINICAL ONCOLOGY, 22(14), (p. 169S).

Herrem, C.J., Tatsumi, T., Olson, W., Finke, J.H., Bukowski, R.M., Kinch, M.S., & Storkus, W.J. (2003). CD8+ and CD4+ T cell-mediated immunity against novel EphA2-derived epitopes in patients with renal cell carcinoma. In FASEB JOURNAL, 17(7), (p. C333).

Ranieri, E., Cellie, M., Pontrelli, P., Di Natale, C., Blasi, A., Capobianco, C., Mancini, V., Ditonno, P., Battaglia, M., Selvaggi, F.P., Storkus, W.J., Grandaliano, G., Schena, F.P., & Gesualdo, L. (2003). CD40/CD40L interaction activates JNK and NF-kB in renal cell carcinoma (RCC). In JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 14, (p. 554A).

Ranieri, E., Tatsumi, T., Kierstead, L.S., Finke, J.H., Bukowski, R.M., Brusic, V., Sidney, J., Sette, A., Di Natale, C., Cellie, M., Kwok, W., Grandaliano, G., Schena, F.P., Gesualdo, L., & Storkus, W.J. (2002). Identification of HLA-DRB1*0401+-restricted MAGE-6 derived epitopes recognized by Th1/Th2 CD4+T-helper cells in renal cell carcinoma (RCC) patients (PTS). In JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 13, (p. 505A).

Björck, P., Falo, L.D., & Storkus, W.J. (2001). Anti-tumor effect and generation of tumor-specific CD8+ T-cells after combined Flt3L and GM-CSF mobilization and dendritic cell therapy. In FASEB JOURNAL, 15(5), (p. A1200).

Larregina, A.T., Watkins, S.C., Erdos, G., Spencer, L.A., Stolz, D.B., Storkus, W.J., & Falo, L.D. (2001). Direct transfection and activation of human Langerhans cells in situ using biolistic delivery of naked DNA. In JOURNAL OF INVESTIGATIVE DERMATOLOGY, 117(4), (p. 1016).

Björck, P., Falo, L.D., & Storkus, W.J. (2000). Generation of CD19+CD11c+ dendritic cells in vivo after combined Flt3L and GM-CSF mobilization. In FASEB JOURNAL, 14(6), (p. A1050).

Björck, P., Falo, L.D., & Storkus, W.J. (2000). Combined Flt3L and GM-CSF mobilization enhance the frequencies of DC subsets exhibiting differential functional capabilities. In FASEB JOURNAL, 14(6), (p. A1132).

Bjorck, P., Lie, W.R., Woulfe, S.L., Klein, B.K., Olson, W., & Storkus, W.J. (2000). Progenipoitin-generated dendritic cells exhibit anti-tumor efficacy in a therapeutic murine tumor model. In BLOOD, 96(11), (p. 294A).

Dong, X., An, B., Kierstead, L.S., Warrino, D., Storkus, W.J., Amoscato, A.A., & Salter, R.D. (2000). Extracelluar proteolysis of antigens by CD 13 on dendritic cells. In FASEB JOURNAL, 14(6), (p. A1053).

Le, P.T., Adams, K.L., Mathews, H.L., Zaya, N., Storkus, W.J., & Ellis, T.M. (2000). Human thymic epithelial cells inhibit the development of NK cells. In FASEB JOURNAL, 14(6), (p. A1021).

Mayordomo, J.I., Tres, A., & Storkus, W.J. (2000). Monitoring of CTL responses in cancer patients. In CLINICAL CANCER RESEARCH, 6, (p. 4473S).

Müller-Berghaus, J., Kierstaed, L.S., Ranieri, E., & Storkus, W.J. (2000). IL-12 and human monocyte-derived DC:: Production and phenotype. In FASEB JOURNAL, 14(6), (p. A1050).

Le, P.T., Adams, K.L., Guo, Z., Storkus, W.J., & Ellis, T.M. (1999). Human thymic epithelial cells inhibit the development and expansion of CD3+CD56+TCRαβ+ thymocytes and CD3-CD56+ natural killer cells in vitro. In FASEB JOURNAL, 13(4), (p. A620).

Dong, X., Storkus, W.J., Watkins, S., Stahl, P.D., & Salter, R.D. (1998). Mannose receptor mediated uptake of agalactosyl IgG by dendritic cells: Implication for rheumatoid arthritis. In FASEB JOURNAL, 12(4), (p. A590).

Dong, X., Storkus, W.J., Watkins, S., Stahl, P.D., & Salter, R.D. (1998). Mannose receptor mediated uptake of agalactosyl IgG by dendritic cells: Implication for rheumatoid arthritis. In JOURNAL OF LEUKOCYTE BIOLOGY, (p. 70).

Herr, W., Ranieri, E., Gesualdo, L., Zarour, H., & Storkus, W.J. (1998). Detection of CD8+ T lymphocytes responsive to Epstein-Barr virus (EBV) peptide antigens in the blood of healthy EBV carriers. In JOURNAL OF LEUKOCYTE BIOLOGY, (p. 74).

Kierstead, L.S., Rice, C., Brusic, V., & Storkus, W.J. (1998). DC facilitate the generation of tumor antigen-specific CD4+ T cells with diverse specificities. In JOURNAL OF LEUKOCYTE BIOLOGY, (p. 73).

Marks, M.S., Calvo, P.A., Frank, D.W., Bieler, B., Tuting, T., & Storkus, W.J. (1998). Cytoplasmic signals required for endosomal sorting of tyrosinase. In FASEB JOURNAL, 12(4), (p. A590).

Ranieri, E., Gesualdo, L., Herr, W., Gambotto, A., Logan, T., Zarour, H., Kirkwood, J.M., & Storkus, W.J. (1998). DC-based immunizing strategies to promote anti-renal cancer T cell response. In JOURNAL OF LEUKOCYTE BIOLOGY, (p. 74).

Tüting, T., Gambotto, A., DeLeo, A.B., & Storkus, W.J. (1998). Adjuvant administration of plasmid DNA expressing IL-12 enhances the induction of anti-melanoma immune responses with plasmid DNA encoding the murine melanosomal protein TRP-2. In JOURNAL OF INVESTIGATIVE DERMATOLOGY, 110(4), (p. 486).

Wilson, C.C., Gambotto, A., Olson, W., Robbins, P., & Storkus, W.J. (1998). Dendritic cells infected with adenovirus-HIV vectors stimulate broad HIV-specific CTL responses. In JOURNAL OF LEUKOCYTE BIOLOGY, (p. 65).

Lotze, M.T., Tahara, H., Storkus, W.J., Suzuki, T., Cai, Q., Couderc, B., & Zitvogel, L. (1997). Cytokine gene therapy of cancer. In CANCER GENE THERAPY, 4(1), (p. 68).

Tuting, T., Baar, J., Schurin, M., Mayordomo, J.I., Zitvogel, L., Tahara, H., Storkus, W.J., DeLeo, A., & Lotze, M.T. (1997). Dendritic cell-based therapy for cancer. In EUROPEAN JOURNAL OF CANCER, 33, (p. 37).

Tuting, T., Kasamon, Y., Martin, D., Wilson, C.C., Baar, J., Lotze, M.T., & Storkus, W.J. (1997). Human blood-derived dendritic cells genetically modified to express melanoma antigens induce primary cytotoxic T cell responses in vitro. In JOURNAL OF INVESTIGATIVE DERMATOLOGY, 108(4), (p. 164).

Tuting, T., Wilson, C.C., Martin, D.I., Baar, J., DeLeo, A., Storkus, W.J., & Lotze, M.T. (1997). DNA vaccines targeting dendritic cells for the immunotherapy of cancer. In CANCER GENE THERAPY, 4(5), (p. 316).

Tuting, T., Zorina, T., Ma, D.I., Wilson, C.C., DeCesare, C.M., DeLeo, A.B., Lotze, M.T., & Storkus, W.J. (1997). Development of dendritic cell-based genetic vaccines for cancer. In DENDRITIC CELLS IN FUNDAMENTAL AND CLINICAL IMMUNOLOGY, VOL 3, 417, (pp. 511-518).Springer US.United States. doi: 10.1007/978-1-4757-9966-8_84.

Wilson, C.C., Tueting, T., Ma, D., Haluszczak, C., Lotze, M., & Storkus, W. (1997). Activation of dendritic cells by surrogate T cell interactions leads to enhanced costimulation, secretion of Th1-associated cytokines, and CTL inductive capacity. In DENDRITIC CELLS IN FUNDAMENTAL AND CLINICAL IMMUNOLOGY, VOL 3, 417, (pp. 335-343).Springer US.United States. doi: 10.1007/978-1-4757-9966-8_55.

Mazzocchi, A., Castelli, C., Traversari, C., Storkus, W.J., Rivoltini, L., Belli, F., Mascheroni, L., Vegetti, C., Anichini, A., & Parmiani, G. (1996). HLA-A3-restricted CTL defined antigens shared among human melanomas but not melanocytes. In FASEB JOURNAL, 10(6), (p. 2520).

MAYORDOMO, J.I., STORKUS, W.J., KAST, W.M., ZORINA, T., DELEO, A.B., & LOTZE, M.T. (1995). BONE-MARROW-DERIVED DENDRITIC CELLS SERVE AS POTENT ADJUVANTS FOR PEPTIDE-BASED ANTITUMOR VACCINES. In JOURNAL OF CELLULAR BIOCHEMISTRY, (p. 21).

ITOH, T., STORKUS, W.J., GORELIK, E., & LOTZE, M.T. (1993). IDENTIFICATION OF MURINE MELANOMA T-CELL EPITOPES RECOGNIZED BY CD8+ TUMOR INFILTRATING LYMPHOCYTES IN THE CONTEXT OF H-2K(B). In JOURNAL OF CELLULAR BIOCHEMISTRY, (p. 138).

LEDER, G.H., STORKUS, W.J., STUBER, G., MODROW, S., & LOTZE, M.T. (1993). P53 PEPTIDES RECONSTITUTE HLA-A2 EXPRESSION AND CONFER SUSCEPTIBILITY TO TIL-LYSIS. In JOURNAL OF CELLULAR BIOCHEMISTRY, (p. 109).

LOTZE, M.T., RUBIN, J.T., STORKUS, W.J., HURD, S., NASTALA, C.L., EDINGTON, H.E., MCKINNEY, T.G., PIPPIN, B., NISHIHARA, K., TAHARA, H., ELDER, E., WHITESIDE, T., ZIMMERMAN, R., & LOUIE, A. (1993). NEW T-CELL GROWTH-FACTORS IN THE TREATMENT OF CANCER. In JOURNAL OF CELLULAR BIOCHEMISTRY, (p. 59).

MAEURER, M.J., STORKUS, W.J., SALTER, R.D., & LOTZE, M.T. (1993). MICROPOCKET USAGE IN HLA-A2 PRESENTATION OF MELANOMA PEPTIDES TO CD8+ TUMOR INFILTRATING LYMPHOCYTES (TIL). In JOURNAL OF CELLULAR BIOCHEMISTRY, (p. 105).

SALTER, R.D., & STORKUS, W.J. (1993). PEPTIDE RELEASE MUTANTS - IDENTIFICATION OF INFLUENZA-DERIVED PEPTIDES BOUND TO HLA-A2 AND HLA-A69. In JOURNAL OF CELLULAR BIOCHEMISTRY, (p. 61).

STORKUS, W.J., MAEURER, M.J., ZEH, H.J., & LOTZE, M.T. (1993). IDENTIFICATION OF HUMAN-MELANOMA DERIVED EPITOPES RECOGNIZED BY HLA-A2 RESTRICTED, CD8+ TUMOR INFILTRATING LYMPHOCYTES. In JOURNAL OF CELLULAR BIOCHEMISTRY, (p. 100).

ZEH, H.J., STORKUS, W.J., BRUNDA, M., GATELY, M., TAHARA, H., & LOTZE, M.T. (1993). IL-12 - A NOVEL-T AND NK STIMULATORY FACTOR - IMPLICATIONS FOR CANCER-IMMUNOTHERAPY. In JOURNAL OF CELLULAR BIOCHEMISTRY, (p. 113).

STORKUS, W., & DAWSON, J.R. (1985). NATURAL-KILLER (NK) CELLS DO NOT GENERATE DETECTABLE OXYGEN METABOLITES AT THE TARGET-CELL INTERFACE. In FEDERATION PROCEEDINGS, 44(4), (p. 1315).