Samira Kiani

We are interested in building and examine genetic circuits that can control the CRISPR gene editing and epigenome editing tools with focus on application for immunotherapy, liver diseases and pain management. Please visit www.kianilab.com We also are actively involved in developing programs to engage public in conversations about science and technology by employing the power of fimmaking. Please visit www.tomorrow.life

  • Delgado, E., & Kiani, S. (2020). A CRISPR Odyssey into Cancer Immunotherapy. CRISPR J, 3(2), 73-75.SAGE Publications. doi: 10.1089/crispr.2020.29090.ede.
  • Ferdosi, S.R., Ewaisha, R., Moghadam, F., Krishna, S., Park, J.G., Ebrahimkhani, M.R., Kiani, S., & Anderson, K.S. (2019). Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes. Nat Commun, 10(1), 1842.Springer Nature. doi: 10.1038/s41467-019-09693-x.
  • Pineda, M., Lear, A., Collins, J.P., & Kiani, S. (2019). Safe CRISPR: Challenges and Possible Solutions. Trends Biotechnol, 37(4), 389-401.Elsevier. doi: 10.1016/j.tibtech.2018.09.010.
  • Yeo, N.C., Chavez, A., Lance-Byrne, A., Chan, Y., Menn, D., Milanova, D., Kuo, C.C., Guo, X., Sharma, S., Tung, A., Cecchi, R.J., Tuttle, M., Pradhan, S., Lim, E.T., Davidsohn, N., Ebrahimkhani, M.R., Collins, J.J., Lewis, N.E., Kiani, S., & Church, G.M. (2018). An enhanced CRISPR repressor for targeted mammalian gene regulation. Nat Methods, 15(8), 611-616.Springer Nature. doi: 10.1038/s41592-018-0048-5.
  • Kiani, S., Chavez, A., Tuttle, M., Hall, R.N., Chari, R., Ter-Ovanesyan, D., Qian, J., Pruitt, B.W., Beal, J., Vora, S., Buchthal, J., Kowal, E.J.K., Ebrahimkhani, M.R., Collins, J.J., Weiss, R., & Church, G. (2015). Cas9 gRNA engineering for genome editing, activation and repression. Nat Methods, 12(11), 1051-1054.Springer Nature. doi: 10.1038/nmeth.3580.
Research Interests
Biochemistry and cell biology
headshot of Samira Kiani
Contact Samira Kiani
Associate Professor
samira.kiani@pitt.edu