Douglass Taylor

My academic interests link large-scale cell, tissue and human, biomimetic, tissue-engineered in vitro disease model profiling with computational and systems biology to optimize drug discovery and diagnostics. I am also developing computational tools to identify and quantify heterogeneity. As the Director of the Drug Institute, I am focusing our efforts in Quantitative Systems Pharmacology in order to change the paradigm in drug discovery, development and diagnostics.

  • PhD in Cell Biology, University at Albany, State University of New York
  • B.S. in Zoology, University of Maryland, Baltimore

  • Aleman, J., K, R., Wiegand, C., Schurdak, M.E., Vernetti, L., Gavlock, D., Reese, C., DeBiasio, R., LaRocca, G., Angarita, Y.D., Gough, A., Soto-Gutierrez, A., Behari, J., Yechoor, V.K., Miedel, M.T., Stern, A.M., Banerjee, I., & Taylor, D.L. (2024). A metabolic dysfunction-associated steatotic liver acinus biomimetic induces pancreatic islet dysfunction in a coupled microphysiology system. Commun Biol, 7(1), 1317.Springer Nature. doi: 10.1038/s42003-024-07006-7.
  • Gough, A., Soto-Gutierrez, A., Vernetti, L., Ebrahimkhani, M.R., Stern, A.M., & Taylor, D.L. (2021). Human biomimetic liver microphysiology systems in drug development and precision medicine. Nat Rev Gastroenterol Hepatol, 18(4), 252-268.Springer Nature. doi: 10.1038/s41575-020-00386-1.
  • Kochanek, P.M., Jackson, T.C., Jha, R.M., Clark, R.S.B., Okonkwo, D.O., Bayır, H., Poloyac, S.M., Wagner, A.K., Empey, P.E., Conley, Y.P., Bell, M.J., Kline, A.E., Bondi, C.O., Simon, D.W., Carlson, S.W., Puccio, A.M., Horvat, C.M., Au, A.K., Elmer, J., Treble-Barna, A., Ikonomovic, M.D., Shutter, L.A., Taylor, D.L., Stern, A.M., Graham, S.H., Kagan, V.E., Jackson, E.K., Wisniewski, S.R., & Dixon, C.E. (2020). Paths to Successful Translation of New Therapies for Severe Traumatic Brain Injury in the Golden Age of Traumatic Brain Injury Research: A Pittsburgh Vision. J Neurotrauma, 37(22), 2353-2371.SAGE Publications. doi: 10.1089/neu.2018.6203.
  • Miedel, M.T., Gavlock, D.C., Jia, S., Gough, A., Taylor, D.L., & Stern, A.M. (2019). Modeling the Effect of the Metastatic Microenvironment on Phenotypes Conferred by Estrogen Receptor Mutations Using a Human Liver Microphysiological System. Sci Rep, 9(1), 8341.Springer Nature. doi: 10.1038/s41598-019-44756-5.
  • Taylor, D.L., Gough, A., Schurdak, M.E., Vernetti, L., Chennubhotla, C.S., Lefever, D., Pei, F., Faeder, J.R., Lezon, T.R., Stern, A.M., & Bahar, I. (2019). Harnessing Human Microphysiology Systems as Key Experimental Models for Quantitative Systems Pharmacology. Handb Exp Pharmacol, 260, 327-367.Springer Nature. doi: 10.1007/164_2019_239.
  • Li, X., George, S.M., Vernetti, L., Gough, A.H., & Taylor, D.L. (2018). A glass-based, continuously zonated and vascularized human liver acinus microphysiological system (vLAMPS) designed for experimental modeling of diseases and ADME/TOX. Lab Chip, 18(17), 2614-2631.Royal Society of Chemistry (RSC). doi: 10.1039/c8lc00418h.
  • Stern, A.M., Schurdak, M.E., Bahar, I., Berg, J.M., & Taylor, D.L. (2016). A Perspective on Implementing a Quantitative Systems Pharmacology Platform for Drug Discovery and the Advancement of Personalized Medicine. J Biomol Screen, 21(6), 521-534.Elsevier. doi: 10.1177/1087057116635818.
  • Gough, A.H., Chen, N., Shun, T.Y., Lezon, T.R., Boltz, R.C., Reese, C.E., Wagner, J., Vernetti, L.A., Grandis, J.R., Lee, A.V., Stern, A.M., Schurdak, M.E., & Taylor, D.L. (2014). Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery. In Paulmurugan, R. (Ed.). PLoS One, 9(7), e102678.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0102678.
  • Bhushan, A., Senutovitch, N., Bale, S.S., McCarty, W.J., Hegde, M., Jindal, R., Golberg, I., Berk Usta, O., Yarmush, M.L., Vernetti, L., Gough, A., Bakan, A., Shun, T.Y., DeBiasio, R., & Lansing Taylor, D. (2013). Towards a three-dimensional microfluidic liver platform for predicting drug efficacy and toxicity in humans. Stem Cell Res Ther, 4 Suppl 1(Suppl 1), S16.Springer Nature. doi: 10.1186/scrt377.
Research Interests
Clinical sciences Biochemistry and cell biology Medical biotechnology
headshot of Douglass Taylor
Contact Douglass Taylor
Distinguished Professor
dltaylor@pitt.edu
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