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Brufsky, A., & Lotze, M.T. (2020). DC/L-SIGNs of hope in the COVID-19 pandemic. J Med Virol, 92(9), 1396-1398.Wiley. doi: 10.1002/jmv.25980.
Brufsky, A., & Lotze, M.T. (2020). Ratcheting down the virulence of SARS-CoV-2 in the COVID-19 pandemic. J Med Virol, 92(11), 2379-2380.Wiley. doi: 10.1002/jmv.26067.
Galluzzi, L., Vitale, I., Warren, S., Adjemian, S., Agostinis, P., Martinez, A.B., Chan, T.A., Coukos, G., Demaria, S., Deutsch, E., Draganov, D., Edelson, R.L., Formenti, S.C., Fucikova, J., Gabriele, L., Gaipl, U.S., Gameiro, S.R., Garg, A.D., Golden, E., Han, J., Harrington, K.J., Hemminki, A., Hodge, J.W., Hossain, D.M.S., Illidge, T., Karin, M., Kaufman, H.L., Kepp, O., Kroemer, G., Lasarte, J.J., Loi, S., Lotze, M.T., Manic, G., Merghoub, T., Melcher, A.A., Mossman, K.L., Prosper, F., Rekdal, Ø., Rescigno, M., Riganti, C., Sistigu, A., Smyth, M.J., Spisek, R., Stagg, J., Strauss, B.E., Tang, D., Tatsuno, K., van Gool, S.W., Vandenabeele, P., Yamazaki, T., Zamarin, D., Zitvogel, L., Cesano, A., & Marincola, F.M. (2020). Consensus guidelines for the definition, detection and interpretation of immunogenic cell death. J Immunother Cancer, 8(1), e000337.BMJ. doi: 10.1136/jitc-2019-000337.
Han, J., & Lotze, M.T. (2020). The Adaptome as Biomarker for Assessing Cancer Immunity and Immunotherapy. Methods Mol Biol, 2055, 369-397.Springer Nature. doi: 10.1007/978-1-4939-9773-2_17.
Kang, R., Zeh, H., Lotze, M., & Tang, D. (2020). The Multifaceted Effects of Autophagy on the Tumor Microenvironment. Adv Exp Med Biol, 1225, 99-114.Springer Nature. doi: 10.1007/978-3-030-35727-6_7.
Ludwig, N., & Lotze, M.T. (2020). A treatise on endothelial biology and exosomes: homage to Theresa Maria Listowska Whiteside. HNO, 68(2), 71-79.Springer Nature. doi: 10.1007/s00106-019-00803-1.
Murthy, P., Zenati, M.S., Al Abbas, A.I., Rieser, C.J., Bahary, N., Lotze, M.T., Zeh, H.J., Zureikat, A.H., & Boone, B.A. (2020). Prognostic Value of the Systemic Immune-Inflammation Index (SII) After Neoadjuvant Therapy for Patients with Resected Pancreatic Cancer. Ann Surg Oncol, 27(3), 898-906.Springer Nature. doi: 10.1245/s10434-019-08094-0.
Zamame Ramirez, J.A., Romagnoli, G.G., Falasco, B.F., Gorgulho, C.M., Sanzochi Fogolin, C., Dos Santos, D.C., Junior, J.P.A., Lotze, M.T., Ureshino, R.P., & Kaneno, R. (2020). Blocking drug-induced autophagy with chloroquine in HCT-116 colon cancer cells enhances DC maturation and T cell responses induced by tumor cell lysate. Int Immunopharmacol, 84, 106495.Elsevier. doi: 10.1016/j.intimp.2020.106495.
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Boone, B.A., Murthy, P., Miller-Ocuin, J.L., Liang, X., Russell, K.L., Loughran, P., Gawaz, M., Lotze, M.T., Zeh, H.J., & Vogel, S. (2019). The platelet NLRP3 inflammasome is upregulated in a murine model of pancreatic cancer and promotes platelet aggregation and tumor growth. Ann Hematol, 98(7), 1603-1610.Springer Nature. doi: 10.1007/s00277-019-03692-0.
Dafni, U., Michielin, O., Lluesma, S.M., Tsourti, Z., Polydoropoulou, V., Karlis, D., Besser, M.J., Haanen, J., Svane, I.M., Ohashi, P.S., Kammula, U.S., Orcurto, A., Zimmermann, S., Trueb, L., Klebanoff, C.A., Lotze, M.T., Kandalaft, L.E., & Coukos, G. (2019). Efficacy of adoptive therapy with tumor-infiltrating lymphocytes and recombinant interleukin-2 in advanced cutaneous melanoma: a systematic review and meta-analysis. Ann Oncol, 30(12), 1902-1913.Elsevier. doi: 10.1093/annonc/mdz398.
Gorgulho, C.M., Romagnoli, G.G., Bharthi, R., & Lotze, M.T. (2019). Johnny on the Spot-Chronic Inflammation Is Driven by HMGB1. Front Immunol, 10(JULY), 1561.Frontiers. doi: 10.3389/fimmu.2019.01561.
Li, G., Sachdev, U., Peters, K., Liang, X., & Lotze, M.T. (2019). The VE-PTP Inhibitor AKB-9778 Improves Antitumor Activity and Diminishes the Toxicity of Interleukin 2 (IL-2) Administration. J Immunother, 42(7), 237-243.Wolters Kluwer. doi: 10.1097/CJI.0000000000000290.
Murthy, P., Ekeke, C.N., Russell, K.L., Butler, S.C., Wang, Y., Luketich, J.D., Soloff, A.C., Dhupar, R., & Lotze, M.T. (2019). Making cold malignant pleural effusions hot: driving novel immunotherapies. Oncoimmunology, 8(4), e1554969.Taylor & Francis. doi: 10.1080/2162402X.2018.1554969.
Soloff, A.C., & Lotze, M.T. (2019). A peaceful death orchestrates immune balance in a chaotic environment. Proc Natl Acad Sci U S A, 116(46), 22901-22903.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1916211116.
Tandon, M., Coudriet, G.M., Criscimanna, A., Socorro, M., Eliliwi, M., Singhi, A.D., Cruz-Monserrate, Z., Bailey, P., Lotze, M.T., Zeh, H., Hu, J., Goffin, V., Gittes, G.K., Biankin, A.V., & Esni, F. (2019). Prolactin Promotes Fibrosis and Pancreatic Cancer Progression. Cancer Res, 79(20), 5316-5327.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-18-3064.
Yang, M., Chen, P., Liu, J., Zhu, S., Kroemer, G., Klionsky, D.J., Lotze, M.T., Zeh, H.J., Kang, R., & Tang, D. (2019). Clockophagy is a novel selective autophagy process favoring ferroptosis. Sci Adv, 5(7), eaaw2238.American Association for the Advancement of Science (AAAS). doi: 10.1126/sciadv.aaw2238.
Anunobi, R., Boone, B.A., Cheh, N., Tang, D., Kang, R., Loux, T., Lotze, M.T., & Zeh, H.J. (2018). Extracellular DNA promotes colorectal tumor cell survival after cytotoxic chemotherapy. J Surg Res, 226, 181-191.Elsevier. doi: 10.1016/j.jss.2018.02.042.
Boone, B.A., Murthy, P., Miller-Ocuin, J., Doerfler, W.R., Ellis, J.T., Liang, X., Ross, M.A., Wallace, C.T., Sperry, J.L., Lotze, M.T., Neal, M.D., & Zeh, H.J. (2018). Chloroquine reduces hypercoagulability in pancreatic cancer through inhibition of neutrophil extracellular traps. BMC Cancer, 18(1), 678.Springer Nature. doi: 10.1186/s12885-018-4584-2.
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Chen, R., Zhu, S., Fan, X.G., Wang, H., Lotze, M.T., Zeh, H.J., Billiar, T.R., Kang, R., & Tang, D. (2018). High mobility group protein B1 controls liver cancer initiation through yes-associated protein -dependent aerobic glycolysis. Hepatology, 67(5), 1823-1841.Wolters Kluwer. doi: 10.1002/hep.29663.
Kim, H.Y., Wang, X., Kang, R., Tang, D., Boone, B.A., Zeh, H.J., Lotze, M.T., & Edwards, W.B. (2018). RAGE-specific single chain Fv for PET imaging of pancreatic cancer. In Hudson, B.I. (Ed.). PLoS One, 13(3), e0192821.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0192821.
Song, X., Zhu, S., Xie, Y., Liu, J., Sun, L., Zeng, D., Wang, P., Ma, X., Kroemer, G., Bartlett, D.L., Billiar, T.R., Lotze, M.T., Zeh, H.J., Kang, R., & Tang, D. (2018). JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice. Gastroenterology, 154(5), 1480-1493.Elsevier. doi: 10.1053/j.gastro.2017.12.004.
Dhupar, R., Van Der Kraak, L., Pennathur, A., Schuchert, M.J., Nason, K.S., Luketich, J.D., & Lotze, M.T. (2017). Targeting Immune Checkpoints in Esophageal Cancer: A High Mutational Load Tumor. Ann Thorac Surg, 103(4), 1340-1349.Elsevier. doi: 10.1016/j.athoracsur.2016.12.011.
Goding, S.R., Yu, S., Bailey, L.M., Lotze, M.T., & Basse, P.H. (2017). Adoptive transfer of natural killer cells promotes the anti-tumor efficacy of T cells. Clin Immunol, 177, 76-86.Elsevier. doi: 10.1016/j.clim.2016.06.013.
Kaltenmeier, C.T., Vollmer, L.L., Vernetti, L.A., Caprio, L., Davis, K., Korotchenko, V.N., Day, B.W., Tsang, M., Hulkower, K.I., Lotze, M.T., & Vogt, A. (2017). A Tumor Cell-Selective Inhibitor of Mitogen-Activated Protein Kinase Phosphatases Sensitizes Breast Cancer Cells to Lymphokine-Activated Killer Cell Activity. J Pharmacol Exp Ther, 361(1), 39-50.Elsevier. doi: 10.1124/jpet.116.239756.
Kang, R., Xie, Y., Zhang, Q., Hou, W., Jiang, Q., Zhu, S., Liu, J., Zeng, D., Wang, H., Bartlett, D.L., Billiar, T.R., Zeh, H.J., Lotze, M.T., & Tang, D. (2017). Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer. Cell Res, 27(7), 916-932.Springer Nature. doi: 10.1038/cr.2017.51.
Murthy, P., Durco, F., Miller-Ocuin, J.L., Takedai, T., Shankar, S., Liang, X., Liu, X., Cui, X., Sachdev, U., Rath, D., Lotze, M.T., Zeh, H.J., Gawaz, M., Weber, A.N., & Vogel, S. (2017). The NLRP3 inflammasome and bruton's tyrosine kinase in platelets co-regulate platelet activation, aggregation, and in vitro thrombus formation. Biochem Biophys Res Commun, 483(1), 230-236.Elsevier. doi: 10.1016/j.bbrc.2016.12.161.
Sachdev, U., & Lotze, M.T. (2017). Perpetual change: autophagy, the endothelium, and response to vascular injury. J Leukoc Biol, 102(2), 221-235.Oxford University Press (OUP). doi: 10.1189/jlb.3RU1116-484RR.
Snyder, H.M., Ahles, T., Calderwood, S., Carrillo, M.C., Chen, H., Chang, C.C.H., Craft, S., De Jager, P., Driver, J.A., Fillit, H., Knopman, D., Lotze, M., Tierney, M.C., Petanceska, S., Saykin, A., Seshadri, S., Shineman, D., & Ganguli, M. (2017). Exploring the nexus of Alzheimer's disease and related dementias with cancer and cancer therapies: A convening of the Alzheimer's Association & Alzheimer's Drug Discovery Foundation. Alzheimers Dement, 13(3), 267-273.Wiley. doi: 10.1016/j.jalz.2016.11.002.
Xie, Y., Zhu, S., Song, X., Sun, X., Fan, Y., Liu, J., Zhong, M., Yuan, H., Zhang, L., Billiar, T.R., Lotze, M.T., Zeh, H.J., Kang, R., Kroemer, G., & Tang, D. (2017). The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity. Cell Rep, 20(7), 1692-1704.Elsevier. doi: 10.1016/j.celrep.2017.07.055.
Xie, Y., Zhu, S., Zhong, M., Yang, M., Sun, X., Liu, J., Kroemer, G., Lotze, M., Zeh, H.J., Kang, R., & Tang, D. (2017). Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma. Gastroenterology, 153(5), 1429-1443.e5.Elsevier. doi: 10.1053/j.gastro.2017.07.036.
Zhu, S., Zhang, Q., Sun, X., Zeh, H.J., Lotze, M.T., Kang, R., & Tang, D. (2017). HSPA5 Regulates Ferroptotic Cell Death in Cancer Cells. Cancer Res, 77(8), 2064-2077.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-16-1979.
Chen, R., Xie, Y., Zhong, X., Fu, Y., Huang, Y., Zhen, Y., Pan, P., Wang, H., Bartlett, D.L., Billiar, T.R., Lotze, M.T., Zeh, H.J., Fan, X.G., Tang, D., & Kang, R. (2016). Novel chemokine-like activities of histones in tumor metastasis. Oncotarget, 7(38), 61728-61740.Impact Journals. doi: 10.18632/oncotarget.11226.
Hou, W., Xie, Y., Song, X., Sun, X., Lotze, M.T., Zeh, H.J., Kang, R., & Tang, D. (2016). Autophagy promotes ferroptosis by degradation of ferritin. Autophagy, 12(8), 1425-1428.Taylor & Francis. doi: 10.1080/15548627.2016.1187366.
Kang, R., Chen, R., Xie, M., Cao, L., Lotze, M.T., Tang, D., & Zeh, H.J. (2016). The Receptor for Advanced Glycation End Products Activates the AIM2 Inflammasome in Acute Pancreatitis. J Immunol, 196(10), 4331-4337.Oxford University Press (OUP). doi: 10.4049/jimmunol.1502340.
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Vogel, S., Rath, D., Borst, O., Mack, A., Loughran, P., Lotze, M.T., Neal, M.D., Billiar, T.R., & Gawaz, M. (2016). Platelet-derived high-mobility group box 1 promotes recruitment and suppresses apoptosis of monocytes. Biochem Biophys Res Commun, 478(1), 143-148.Elsevier. doi: 10.1016/j.bbrc.2016.07.078.
Xie, Y., Song, X., Sun, X., Huang, J., Zhong, M., Lotze, M.T., Zeh, H.J., Kang, R., & Tang, D. (2016). Identification of baicalein as a ferroptosis inhibitor by natural product library screening. Biochem Biophys Res Commun, 473(4), 775-780.Elsevier. doi: 10.1016/j.bbrc.2016.03.052.
Yoo, J.Y., Jaime-Ramirez, A.C., Bolyard, C., Dai, H., Nallanagulagari, T., Wojton, J., Hurwitz, B.S., Relation, T., Lee, T.J., Lotze, M.T., Yu, J.G., Zhang, J., Croce, C.M., Yu, J., Caligiuri, M.A., Old, M., & Kaur, B. (2016). Bortezomib Treatment Sensitizes Oncolytic HSV-1-Treated Tumors to NK Cell Immunotherapy. Clin Cancer Res, 22(21), 5265-5276.American Association for Cancer Research (AACR). doi: 10.1158/1078-0432.CCR-16-1003.
Zhang, X., Rao, A., Sette, P., Deibert, C., Pomerantz, A., Kim, W.J., Kohanbash, G., Chang, Y., Park, Y., Engh, J., Choi, J., Chan, T., Okada, H., Lotze, M., Grandi, P., & Amankulor, N. (2016). IDH mutant gliomas escape natural killer cell immune surveillance by downregulation of NKG2D ligand expression. Neuro Oncol, 18(10), 1402-1412.Oxford University Press (OUP). doi: 10.1093/neuonc/now061.
Apetoh, L., Smyth, M.J., Drake, C.G., Abastado, J.P., Apte, R.N., Ayyoub, M., Blay, J.Y., Bonneville, M., Butterfield, L.H., Caignard, A., Castelli, C., Cavallo, F., Celis, E., Chen, L., Colombo, M.P., Comin-Anduix, B., Coukos, G., Dhodapkar, M.V., Dranoff, G., Frazer, I.H., Fridman, W.H., Gabrilovich, D.I., Gilboa, E., Gnjatic, S., Jäger, D., Kalinski, P., Kaufman, H.L., Kiessling, R., Kirkwood, J., Knuth, A., Liblau, R., Lotze, M.T., Lugli, E., Marincola, F., Melero, I., Melief, C.J., Mempel, T.R., Mittendorf, E.A., Odun, K., Overwijk, W.W., Palucka, A.K., Parmiani, G., Ribas, A., Romero, P., Schreiber, R.D., Schuler, G., Srivastava, P.K., Tartour, E., Valmori, D., van der Burg, S.H., van der Bruggen, P., van den Eynde, B.J., Wang, E., Zou, W., Whiteside, T.L., Speiser, D.E., Pardoll, D.M., Restifo, N.P., & Anderson, A.C. (2015). Consensus nomenclature for CD8+ T cell phenotypes in cancer. Oncoimmunology, 4(4), e998538.Taylor & Francis. doi: 10.1080/2162402X.2014.998538.
Boone, B.A., Bahary, N., Zureikat, A.H., Moser, A.J., Normolle, D.P., Wu, W.C., Singhi, A.D., Bao, P., Bartlett, D.L., Liotta, L.A., Espina, V., Loughran, P., Lotze, M.T., & Zeh, H.J. (2015). Safety and Biologic Response of Pre-operative Autophagy Inhibition in Combination with Gemcitabine in Patients with Pancreatic Adenocarcinoma. Ann Surg Oncol, 22(13), 4402-4410.Springer Nature. doi: 10.1245/s10434-015-4566-4.
Boone, B.A., Orlichenko, L., Schapiro, N.E., Loughran, P., Gianfrate, G.C., Ellis, J.T., Singhi, A.D., Kang, R., Tang, D., Lotze, M.T., & Zeh, H.J. (2015). The receptor for advanced glycation end products (RAGE) enhances autophagy and neutrophil extracellular traps in pancreatic cancer. Cancer Gene Ther, 22(6), 326-334.Springer Nature. doi: 10.1038/cgt.2015.21.
Chen, M., Liu, Y., Varley, P., Chang, Y., He, X.X., Huang, H., Tang, D., Lotze, M.T., Lin, J., & Tsung, A. (2015). High-Mobility Group Box 1 Promotes Hepatocellular Carcinoma Progression through miR-21-Mediated Matrix Metalloproteinase Activity. Cancer Res, 75(8), 1645-1656.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-14-2147.
Chen, R., Fu, S., Fan, X.G., Lotze, M.T., Zeh, H.J., Tang, D., & Kang, R. (2015). Nuclear DAMP complex-mediated RAGE-dependent macrophage cell death. Biochem Biophys Res Commun, 458(3), 650-655.Elsevier. doi: 10.1016/j.bbrc.2015.01.159.
Diniz, B.S., Sibille, E., Ding, Y., Tseng, G., Aizenstein, H.J., Lotrich, F., Becker, J.T., Lopez, O.L., Lotze, M.T., Klunk, W.E., Reynolds, C.F., & Butters, M.A. (2015). Plasma biosignature and brain pathology related to persistent cognitive impairment in late-life depression. Mol Psychiatry, 20(5), 594-601.Springer Nature. doi: 10.1038/mp.2014.76.
Ganguli, M., & Lotze, M.T. (2015). Parkinson Disease and Malignant Disease: Minding Cancer's Own Business. JAMA Oncol, 1(5), 641-642.American Medical Association (AMA). doi: 10.1001/jamaoncol.2015.1810.
Huang, J., Xie, Y., Sun, X., Zeh, H.J., Kang, R., Lotze, M.T., & Tang, D. (2015). DAMPs, ageing, and cancer: The 'DAMP Hypothesis'. Ageing Res Rev, 24(Pt A), 3-16.Elsevier. doi: 10.1016/j.arr.2014.10.004.
Liu, Y., Yan, W., Tohme, S., Chen, M., Fu, Y., Tian, D., Lotze, M., Tang, D., & Tsung, A. (2015). Hypoxia induced HMGB1 and mitochondrial DNA interactions mediate tumor growth in hepatocellular carcinoma through Toll-like receptor 9. J Hepatol, 63(1), 114-121.Elsevier. doi: 10.1016/j.jhep.2015.02.009.
Sehgal, A.R., Konig, H., Johnson, D.E., Tang, D., Amaravadi, R.K., Boyiadzis, M., & Lotze, M.T. (2015). You eat what you are: autophagy inhibition as a therapeutic strategy in leukemia. Leukemia, 29(3), 517-525.Springer Nature. doi: 10.1038/leu.2014.349.
Shakir, M., Tang, D., Zeh, H.J., Tang, S.W., Anderson, C.J., Bahary, N., & Lotze, M.T. (2015). The chemokine receptors CXCR4/CXCR7 and their primary heterodimeric ligands CXCL12 and CXCL12/high mobility group box 1 in pancreatic cancer growth and development: finding flow. Pancreas, 44(4), 528-534.Wolters Kluwer. doi: 10.1097/MPA.0000000000000298.
Vogel, S., Bodenstein, R., Chen, Q., Feil, S., Feil, R., Rheinlaender, J., Schäffer, T.E., Bohn, E., Frick, J.S., Borst, O., Münzer, P., Walker, B., Markel, J., Csanyi, G., Pagano, P.J., Loughran, P., Jessup, M.E., Watkins, S.C., Bullock, G.C., Sperry, J.L., Zuckerbraun, B.S., Billiar, T.R., Lotze, M.T., Gawaz, M., & Neal, M.D. (2015). Platelet-derived HMGB1 is a critical mediator of thrombosis. J Clin Invest, 125(12), 4638-4654.American Society for Clinical Investigation. doi: 10.1172/JCI81660.
Yu, Y., Xie, Y., Cao, L., Yang, L., Yang, M., Lotze, M.T., Zeh, H.J., Kang, R., & Tang, D. (2015). The ferroptosis inducer erastin enhances sensitivity of acute myeloid leukemia cells to chemotherapeutic agents. Mol Cell Oncol, 2(4), e1054549.Taylor & Francis. doi: 10.1080/23723556.2015.1054549.
Zhu, X., Messer, J.S., Wang, Y., Lin, F., Cham, C.M., Chang, J., Billiar, T.R., Lotze, M.T., Boone, D.L., & Chang, E.B. (2015). Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation. J Clin Invest, 125(3), 1098-1110.American Society for Clinical Investigation. doi: 10.1172/JCI76344.
Bauer, E.M., Zheng, H., Lotze, M.T., & Bauer, P.M. (2014). Recombinant human interferon alpha 2b prevents and reverses experimental pulmonary hypertension. In Zhao, Y.Y. (Ed.). PLoS One, 9(5), e96720.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0096720.
Boone, B.A., & Lotze, M.T. (2014). Targeting damage-associated molecular pattern molecules (DAMPs) and DAMP receptors in melanoma. Methods Mol Biol, 1102, 537-552.Springer Nature. doi: 10.1007/978-1-62703-727-3_29.
Eisenbacher, J.L., Schrezenmeier, H., Jahrsdörfer, B., Kaltenmeier, C., Rojewski, M.T., Yildiz, T., Beyer, T., Erle, A., Wiegmann, D.S., Grassl, S., Hang, R., Körper, S., Wiesneth, M., Lotze, M.T., & Lotfi, R. (2014). S100A4 and uric acid promote mesenchymal stromal cell induction of IL-10+/IDO+ lymphocytes. J Immunol, 192(12), 6102-6110.Oxford University Press (OUP). doi: 10.4049/jimmunol.1303144.
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Kang, R., Tang, D., Schapiro, N.E., Loux, T., Livesey, K.M., Billiar, T.R., Wang, H., Van Houten, B., Lotze, M.T., & Zeh, H.J. (2014). The HMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating mitochondrial bioenergetics. Oncogene, 33(5), 567-577.Springer Nature. doi: 10.1038/onc.2012.631.
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Kaufmann, S.H.E., Lange, C., Rao, M., Balaji, K.N., Lotze, M., Schito, M., Zumla, A.I., & Maeurer, M. (2014). Progress in tuberculosis vaccine development and host-directed therapies--a state of the art review. Lancet Respir Med, 2(4), 301-320.Elsevier. doi: 10.1016/S2213-2600(14)70033-5.
Milutinovic, P.S., Englert, J.M., Crum, L.T., Mason, N.S., Ramsgaard, L., Enghild, J.J., Sparvero, L.J., Lotze, M.T., & Oury, T.D. (2014). Clearance kinetics and matrix binding partners of the receptor for advanced glycation end products. In Abrams, W.R. (Ed.). PLoS One, 9(3), e88259.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0088259.
Tang, D., Kang, R., Van Houten, B., Zeh, H.J., Billiar, T.R., & Lotze, M.T. (2014). High mobility group box 1 (HMGB1) phenotypic role revealed with stress. Mol Med, 20(1), 359-362.Springer Nature. doi: 10.2119/molmed.2014.00063.
Wang, W., & Lotze, M.T. (2014). Good things come in small packages: exosomes, immunity and cancer. Cancer Gene Ther, 21(4), 139-141.Springer Nature. doi: 10.1038/cgt.2014.14.
Wang, W., Vernon, P., Li, G., Sampath, P., Stephen, T., Liang, X., & Lotze, M. (2014). Depletion of high mobility group box 1(HMGB1) in dendritic cells (DCs) suppresses tumorigenesis and promotes viral clearance. Journal for ImmunoTherapy of Cancer, 2(Suppl 3), p64.BMJ. doi: 10.1186/2051-1426-2-s3-p64.
Yang, L., Xie, M., Yang, M., Yu, Y., Zhu, S., Hou, W., Kang, R., Lotze, M.T., Billiar, T.R., Wang, H., Cao, L., & Tang, D. (2014). PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis. Nat Commun, 5(1), 4436.Springer Nature. doi: 10.1038/ncomms5436.
Criscimanna, A., Duan, L.J., Rhodes, J.A., Fendrich, V., Wickline, E., Hartman, D.J., Monga, S.P.S., Lotze, M.T., Gittes, G.K., Fong, G.H., & Esni, F. (2013). PanIN-specific regulation of Wnt signaling by HIF2α during early pancreatic tumorigenesis. Cancer Res, 73(15), 4781-4790.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-13-0566.
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Hou, W., Zhang, Q., Yan, Z., Chen, R., Zeh Iii, H.J., Kang, R., Lotze, M.T., & Tang, D. (2013). Strange attractors: DAMPs and autophagy link tumor cell death and immunity. Cell Death Dis, 4(12), e966.Springer Nature. doi: 10.1038/cddis.2013.493.
Kang, R., Tang, D., Lotze, M.T., & Zeh Iii, H.J. (2013). Autophagy is required for IL-2-mediated fibroblast growth. Exp Cell Res, 319(4), 556-565.Elsevier. doi: 10.1016/j.yexcr.2012.11.012.
Kang, R., Zhang, Q., Zeh, H.J., Lotze, M.T., & Tang, D. (2013). HMGB1 in cancer: good, bad, or both?. Clin Cancer Res, 19(15), 4046-4057.American Association for Cancer Research (AACR). doi: 10.1158/1078-0432.CCR-13-0495.
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Kim, S., Kim, S.Y., Pribis, J.P., Lotze, M., Mollen, K.P., Shapiro, R., Loughran, P., Scott, M.J., & Billiar, T.R. (2013). Signaling of high mobility group box 1 (HMGB1) through toll-like receptor 4 in macrophages requires CD14. Mol Med, 19(1), 88-98.Springer Nature. doi: 10.2119/molmed.2012.00306.
Li, G., Liang, X., & Lotze, M.T. (2013). HMGB1: The Central Cytokine for All Lymphoid Cells. Front Immunol, 4(MAR), 68.Frontiers. doi: 10.3389/fimmu.2013.00068.
Li, G., Tang, D., & Lotze, M.T. (2013). Ménage à Trois in stress: DAMPs, redox and autophagy. Semin Cancer Biol, 23(5), 380-390.Elsevier. doi: 10.1016/j.semcancer.2013.08.002.
Lotze, M.T., Maranchie, J., & Appleman, L. (2013). Inhibiting autophagy: a novel approach for the treatment of renal cell carcinoma. Cancer J, 19(4), 341-347.Wolters Kluwer. doi: 10.1097/PPO.0b013e31829da0d6.
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Lu, Y., Zhang, Z., Yan, Z., Chen, L., Deng, W., Lotze, M., Wang, Z., Lin, X., & Li, L.Y. (2013). Recombinant GnRH-p53 protein sensitizes breast cancer cells to 5-fluorouracil-induced apoptosis in vitro and in vivo. Apoptosis, 18(10), 1214-1223.Springer Nature. doi: 10.1007/s10495-013-0863-1.
Rubartelli, A., Lotze, M.T., Latz, E., & Manfredi, A. (2013). Mechanisms of sterile inflammation. Front Immunol, 4(NOV), 398.Frontiers. doi: 10.3389/fimmu.2013.00398.
Tang, D., & Lotze, M.T. (2013). Autophagy and the Tumor Microenvironment. In Autophagy and Cancer. (pp. 167-189).Springer Nature. doi: 10.1007/978-1-4614-6561-4_9.
Tang, S., Bonaroti, J., Unlu, S., Liang, X., Tang, D., Zeh, H.J., & Lotze, M.T. (2013). Sweating the small stuff: microRNAs and genetic changes define pancreatic cancer. Pancreas, 42(5), 740-759.Wolters Kluwer. doi: 10.1097/MPA.0b013e3182854ab0.
Vernon, P.J., Loux, T.J., Schapiro, N.E., Kang, R., Muthuswamy, R., Kalinski, P., Tang, D., Lotze, M.T., & Zeh, H.J. (2013). The receptor for advanced glycation end products promotes pancreatic carcinogenesis and accumulation of myeloid-derived suppressor cells. J Immunol, 190(3), 1372-1379.Oxford University Press (OUP). doi: 10.4049/jimmunol.1201151.
Vernon, P.J., Zeh Iii, H.J., & Lotze, M.T. (2013). The myeloid response to pancreatic carcinogenesis is regulated by the receptor for advanced glycation end-products. Oncoimmunology, 2(5), e24184.Taylor & Francis. doi: 10.4161/onci.24184.
Whiteside, T.L., Robinson, B.W.S., June, C.H., & Lotze, M.T. (2013). Principles of tumor immunology. In Clinical Immunology. (pp. 925-934).Elsevier. doi: 10.1016/b978-0-7234-3691-1.00090-8.
Zhang, Q., Kang, R., Zeh, H.J., Lotze, M.T., & Tang, D. (2013). DAMPs and autophagy: cellular adaptation to injury and unscheduled cell death. Autophagy, 9(4), 451-458.Taylor & Francis. doi: 10.4161/auto.23691.
Buchser, W.J., Laskow, T.C., Pavlik, P.J., Lin, H.M., & Lotze, M.T. (2012). Cell-mediated autophagy promotes cancer cell survival. Cancer Res, 72(12), 2970-2979.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-11-3396.
Ferris, R.L., Lotze, M.T., Leong, S.P.L., Hoon, D.S.B., & Morton, D.L. (2012). Lymphatics, lymph nodes and the immune system: barriers and gateways for cancer spread. Clin Exp Metastasis, 29(7), 729-736.Springer Nature. doi: 10.1007/s10585-012-9520-2.
Kang, R., Loux, T., Tang, D., Schapiro, N.E., Vernon, P., Livesey, K.M., Krasinskas, A., Lotze, M.T., & Zeh, H.J. (2012). The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia. Proc Natl Acad Sci U S A, 109(18), 7031-7036.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1113865109.
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Torti, F.M., Altieri, D., Broach, J., Fan, H., Lotze, M., Manfredi, J., Matrisian, L., Yu, D., Giaccia, A., & Cancer Biology Training Consortium. (2008). Ph.D. Training in cancer biology. Cancer Res, 68(22), 9122-9124.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-08-2626.
Vakkila, J., Demarco, R.A., & Lotze, M.T. (2008). Coordinate NF-kappaB and STAT1 activation promotes development of myeloid type 1 dendritic cells. Scand J Immunol, 67(3), 260-269.Wiley. doi: 10.1111/j.1365-3083.2007.02068.x.
Zetterström, C.K., Jiang, W., Wähämaa, H., Ostberg, T., Aveberger, A.C., Schierbeck, H., Lotze, M.T., Andersson, U., Pisetsky, D.S., & Erlandsson Harris, H. (2008). Pivotal advance: inhibition of HMGB1 nuclear translocation as a mechanism for the anti-rheumatic effects of gold sodium thiomalate. J Leukoc Biol, 83(1), 31-38.Oxford University Press (OUP). doi: 10.1189/jlb.0507323.
Atkins, M.B., Carbone, D., Coukos, G., Dhodapkar, M., Ernstoff, M.S., Finke, J., Gajewski, T.F., Gollob, J., Lotze, M.T., Storkus, W., & Weiner, L.M. (2007). Report on the ISBTC mini-symposium on biologic effects of targeted therapeutics. J Immunother, 30(6), 577-590.Wolters Kluwer. doi: 10.1097/CJI.0b013e318064e7b2.
Del Vecchio, M., Bajetta, E., Canova, S., Lotze, M.T., Wesa, A., Parmiani, G., & Anichini, A. (2007). Interleukin-12: biological properties and clinical application. Clin Cancer Res, 13(16), 4677-4685.American Association for Cancer Research (AACR). doi: 10.1158/1078-0432.CCR-07-0776.
Dong, X.D.E., Ito, N., Lotze, M.T., Demarco, R.A., Popovic, P., Shand, S.H., Watkins, S., Winikoff, S., Brown, C.K., Bartlett, D.L., & Zeh, H.J. (2007). High mobility group box I (HMGB1) release from tumor cells after treatment: implications for development of targeted chemoimmunotherapy. J Immunother, 30(6), 596-606.Wolters Kluwer. doi: 10.1097/CJI.0b013e31804efc76.
Ellerman, J.E., Brown, C.K., de Vera, M., Zeh, H.J., Billiar, T., Rubartelli, A., & Lotze, M.T. (2007). Masquerader: high mobility group box-1 and cancer. Clin Cancer Res, 13(10), 2836-2848.American Association for Cancer Research (AACR). doi: 10.1158/1078-0432.CCR-06-1953.
Farkas, A.M., Kilgore, T.M., & Lotze, M.T. (2007). Detecting DNA: getting and begetting cancer. Curr Opin Investig Drugs, 8(12), 981-986.
Hikawa, H., Lotze, M.T., & Rosenblum, W.D. (2007). Induction of peripheral tolerance by local delivery of dendritic cell progenitors to cardiac allografts in a murine heterotopic heart transplantation model. Gen Thorac Cardiovasc Surg, 55(8), 307-314.Springer Nature. doi: 10.1007/s11748-007-0133-7.
Ito, N., DeMarco, R.A., Mailliard, R.B., Han, J., Rabinowich, H., Kalinski, P., Stolz, D.B., Zeh, H.J., & Lotze, M.T. (2007). Cytolytic cells induce HMGB1 release from melanoma cell lines. J Leukoc Biol, 81(1), 75-83.Oxford University Press (OUP). doi: 10.1189/jlb.0306169.
Kavanagh, B., Ko, A., Venook, A., Margolin, K., Zeh, H., Lotze, M., Schillinger, B., Liu, W., Lu, Y., Mitsky, P., Schilling, M., Bercovici, N., Loudovaris, M., Guillermo, R., Lee, S.M., Bender, J., Mills, B., & Fong, L. (2007). Vaccination of metastatic colorectal cancer patients with matured dendritic cells loaded with multiple major histocompatibility complex class I peptides. J Immunother, 30(7), 762-772.Wolters Kluwer. doi: 10.1097/CJI.0b013e318133451c.
Levy, R.M., Mollen, K.P., Prince, J.M., Kaczorowski, D.J., Vallabhaneni, R., Liu, S., Tracey, K.J., Lotze, M.T., Hackam, D.J., Fink, M.P., Vodovotz, Y., & Billiar, T.R. (2007). Systemic inflammation and remote organ injury following trauma require HMGB1. Am J Physiol Regul Integr Comp Physiol, 293(4), R1538-R1544.American Physiological Society. doi: 10.1152/ajpregu.00272.2007.
Lotfi, R., Lee, J.J., & Lotze, M.T. (2007). Eosinophilic granulocytes and damage-associated molecular pattern molecules (DAMPs): role in the inflammatory response within tumors. J Immunother, 30(1), 16-28.Wolters Kluwer. doi: 10.1097/01.cji.0000211324.53396.f6.
Lotze, M.T., & Gray, J. (2007). A life in passing: Jonathan Gray. J Transl Med, 5(1), 54.Springer Nature. doi: 10.1186/1479-5876-5-54.
Lotze, M.T., Deisseroth, A., & Rubartelli, A. (2007). Damage associated molecular pattern molecules. Clin Immunol, 124(1), 1-4.Elsevier. doi: 10.1016/j.clim.2007.02.006.
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Rubartelli, A., & Lotze, M.T. (2007). Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox. Trends Immunol, 28(10), 429-436.Elsevier. doi: 10.1016/j.it.2007.08.004.
Tsung, A., Zheng, N., Jeyabalan, G., Izuishi, K., Klune, J.R., Geller, D.A., Lotze, M.T., Lu, L., & Billiar, T.R. (2007). Increasing numbers of hepatic dendritic cells promote HMGB1-mediated ischemia-reperfusion injury. J Leukoc Biol, 81(1), 119-128.Oxford University Press (OUP). doi: 10.1189/jlb.0706468.
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D'Aiuto, L., De Marco, R., Edward, N., Rizzo, A., Chaillet, J.R., Montecalvo, A., Lotze, M.T., & Gambotto, A. (2006). Evidence of the capability of the CMV enhancer to activate in trans gene expression in mammalian cells. DNA Cell Biol, 25(3), 171-180.Mary Ann Liebert. doi: 10.1089/dna.2006.25.171.
Eto, M., Bennouna, J., Hunter, O.C., Lotze, M.T., & Amoscato, A.A. (2006). Importance of C16 ceramide accumulation during apoptosis in prostate cancer cells. Int J Urol, 13(2), 148-156.Wiley. doi: 10.1111/j.1442-2042.2006.01249.x.
Izuishi, K., Tsung, A., Jeyabalan, G., Critchlow, N.D., Li, J., Tracey, K.J., Demarco, R.A., Lotze, M.T., Fink, M.P., Geller, D.A., & Billiar, T.R. (2006). Cutting edge: high-mobility group box 1 preconditioning protects against liver ischemia-reperfusion injury. J Immunol, 176(12), 7154-7158.Oxford University Press (OUP). doi: 10.4049/jimmunol.176.12.7154.
Lotze, M.T. (2006). Cancer gene therapy: the power of negative thinking. Gene Ther, 13(3), 191-193.Springer Nature. doi: 10.1038/sj.gt.3302633.
Lotze, M.T., & Yu, Y. (2006). Cancer genomics: the unknown unknowns. Curr Opin Investig Drugs, 7(6), 497-500.
Montag, D.T., & Lotze, M.T. (2006). Rapid flow cytometric measurement of cytokine-induced phosphorylation pathways [CIPP] in human peripheral blood leukocytes. Clin Immunol, 121(2), 215-226.Elsevier. doi: 10.1016/j.clim.2006.06.013.
Montag, D.T., & Lotze, M.T. (2006). Successful simultaneous measurement of cell membrane and cytokine induced phosphorylation pathways [CIPP] in human peripheral blood mononuclear cells. J Immunol Methods, 313(1-2), 48-60.Elsevier. doi: 10.1016/j.jim.2006.03.014.
Popovic, P.J., DeMarco, R., Lotze, M.T., Winikoff, S.E., Bartlett, D.L., Krieg, A.M., Guo, Z.S., Brown, C.K., Tracey, K.J., & Zeh, H.J. (2006). High mobility group B1 protein suppresses the human plasmacytoid dendritic cell response to TLR9 agonists. J Immunol, 177(12), 8701-8707.Oxford University Press (OUP). doi: 10.4049/jimmunol.177.12.8701.
Tao, R., Wang, L., Chen, C.H., Wang, S.H., Demarco, R.A., Lotze, M.T., Thai, N.L., Fung, J.J., Lu, L., & Qian, S. (2006). Mechanistic insights into achievement of cardiac allograft long-term survival by treatment with immature dendritic cells and sub-dose sirolimus. J Heart Lung Transplant, 25(3), 310-319.Elsevier. doi: 10.1016/j.healun.2005.10.005.
Vakkila, J., Jaffe, R., Michelow, M., & Lotze, M.T. (2006). Pediatric cancers are infiltrated predominantly by macrophages and contain a paucity of dendritic cells: a major nosologic difference with adult tumors. Clin Cancer Res, 12(7 Pt 1), 2049-2054.American Association for Cancer Research (AACR). doi: 10.1158/1078-0432.CCR-05-1824.
Wang, Y., Zheng, N., Lu, Z., Wu, W., Wang, L., Nakao, A., Lotze, M.T., Langer, C.E., Fung, J.J., Qian, S., & Lu, L. (2006). In vivo expansion of two distinct dendritic cells in mouse livers and its impact on liver immune regulation. Liver Transpl, 12(12), 1850-1861.Wolters Kluwer. doi: 10.1002/lt.20919.
DeMarco, R.A., Fink, M.P., & Lotze, M.T. (2005). Monocytes promote natural killer cell interferon gamma production in response to the endogenous danger signal HMGB1. Mol Immunol, 42(4), 433-444.Elsevier. doi: 10.1016/j.molimm.2004.07.023.
Fujii, S.I., Nishimura, M.I., & Lotze, M.T. (2005). Regulatory balance between the immune response of tumor antigen-specific T-cell receptor gene-transduced CD8 T cells and the suppressive effects of tolerogenic dendritic cells. Cancer Sci, 96(12), 897-902.Wiley. doi: 10.1111/j.1349-7006.2005.00124.x.
Guo, Z.S., Naik, A., O'Malley, M.E., Popovic, P., Demarco, R., Hu, Y., Yin, X., Yang, S., Zeh, H.J., Moss, B., Lotze, M.T., & Bartlett, D.L. (2005). The enhanced tumor selectivity of an oncolytic vaccinia lacking the host range and antiapoptosis genes SPI-1 and SPI-2. Cancer Res, 65(21), 9991-9998.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-05-1630.
Hauskrecht, M., Pelikan, R., Malehorn, D.E., Bigbee, W.L., Lotze, M.T., Zeh, H.J., Whitcomb, D.C., & Lyons-Weiler, J. (2005). Feature Selection for Classification of SELDI-TOF-MS Proteomic Profiles. Appl Bioinformatics, 4(4), 227-246.Springer Nature. doi: 10.2165/00822942-200504040-00003.
Kalinski, P., Mailliard, R.B., Giermasz, A., Zeh, H.J., Basse, P., Bartlett, D.L., Kirkwood, J.M., Lotze, M.T., & Herberman, R.B. (2005). Natural killer-dendritic cell cross-talk in cancer immunotherapy. Expert Opin Biol Ther, 5(10), 1303-1315.Taylor & Francis. doi: 10.1517/14712598.5.10.1303.
Lotze, M., & Thomson, A. (2005). Measuring Immunity: Basic Biology and Clinical ssessment.
Lotze, M., & Thomson, A. (2005). Measuring Immunity. Elsevier. doi: 10.1016/b978-0-12-455900-4.x5260-x.
Lotze, M.T., & Tracey, K.J. (2005). High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat Rev Immunol, 5(4), 331-342.Springer Nature. doi: 10.1038/nri1594.
Lotze, M.T., Lu, L., & Taylor, D.L. (2005). Imaging Cytometry: High Content Screening for Large-Scale Cell Research. In Measuring Immunity. (pp. 660-665).Elsevier. doi: 10.1016/b978-012455900-4/50320-2.
Lotze, M.T., Wang, E., Marincola, F.M., Hanna, N., Bugelski, P.J., Burns, C.A., Coukos, G., Damle, N., Godfrey, T.E., Howell, W.M., Panelli, M.C., Perricone, M.A., Petricoin, E.F., Sauter, G., Scheibenbogen, C., Shivers, S.C., Taylor, D.L., Weinstein, J.N., & Whiteside, T.L. (2005). Workshop on cancer biometrics: identifying biomarkers and surrogates of cancer in patients: a meeting held at the Masur Auditorium, National Institutes of Health. J Immunother, 28(2), 79-119.Wolters Kluwer. doi: 10.1097/01.cji.0000154251.20125.2e.
Numasaki, M., Watanabe, M., Suzuki, T., Takahashi, H., Nakamura, A., McAllister, F., Hishinuma, T., Goto, J., Lotze, M.T., Kolls, J.K., & Sasaki, H. (2005). IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis. J Immunol, 175(9), 6177-6189.Oxford University Press (OUP). doi: 10.4049/jimmunol.175.9.6177.
Pelikan, R., Lotze, M.T., Lyons-Weiler, J., Malehorn, D., & Hauskrecht, M. (2005). Serum Proteomic Profiling and Analysis. In Measuring Immunity. (pp. 649-659).Elsevier. doi: 10.1016/b978-012455900-4/50319-6.
Takahashi, H., Numasaki, M., Lotze, M.T., & Sasaki, H. (2005). Interleukin-17 enhances bFGF-, HGF- and VEGF-induced growth of vascular endothelial cells. Immunol Lett, 98(2), 189-193.Elsevier. doi: 10.1016/j.imlet.2004.11.012.
Tsung, A., Hoffman, R.A., Izuishi, K., Critchlow, N.D., Nakao, A., Chan, M.H., Lotze, M.T., Geller, D.A., & Billiar, T.R. (2005). Hepatic ischemia/reperfusion injury involves functional TLR4 signaling in nonparenchymal cells. J Immunol, 175(11), 7661-7668.Oxford University Press (OUP). doi: 10.4049/jimmunol.175.11.7661.
Tsung, A., Sahai, R., Tanaka, H., Nakao, A., Fink, M.P., Lotze, M.T., Yang, H., Li, J., Tracey, K.J., Geller, D.A., & Billiar, T.R. (2005). The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J Exp Med, 201(7), 1135-1143.Rockefeller University Press. doi: 10.1084/jem.20042614.
Vakkila, J., DeMarco, R.A., & Lotze, M.T. (2005). Imaging analysis of STAT1 and NF-kappaB translocation in dendritic cells at the single cell level. Drug Discov Today, Suppl, 19-30.
Vakkila, J., Lotze, M.T., Riga, C., & Jaffe, R. (2005). A basis for distinguishing cultured dendritic cells and macrophages in cytospins and fixed sections. Pediatr Dev Pathol, 8(1), 43-51.SAGE Publications. doi: 10.1007/s10024-004-5045-2.
Winikoff, S.E., Zeh, H.J., DeMarco, R., & Lotze, M.T. (2005). Handling and Storage of Cells and Sera: Practical Considerations. In Measuring Immunity. (pp. 233-236).Elsevier. doi: 10.1016/b978-012455900-4/50281-6.
Winikoff, S.E., Zeh, H.J., DeMarco, R., & Lotze, M.T. (2005). Cytolytic Assays. In Measuring Immunity. (pp. 343-349).Elsevier. doi: 10.1016/b978-012455900-4/50291-9.
Zeh, H.J., & Lotze, M.T. (2005). Addicted to death: invasive cancer and the immune response to unscheduled cell death. J Immunother, 28(1), 1-9.Wolters Kluwer. doi: 10.1097/00002371-200501000-00001.
Zeh, H.J., Winikoff, S., Landsittel, D.P., Gorelik, E., Marrangoni, A.M., Velikokhatnaya, L., Winans, M.T., Lee, K., Moser, A., Bartlett, D., Lotze, M.T., Siegfried, J.M., Whitcomb, D., Papacristou, G., Slivka, A., Bigbee, W.L., & Lokshin, A.E. (2005). Multianalyte profiling of serum cytokines for detection of pancreatic cancer. Cancer Biomark, 1(6), 259-269.SAGE Publications. doi: 10.3233/cbm-2005-1601.
Agha-Mohammadi, S., O'Malley, M., Etemad, A., Wang, Z., Xiao, X., & Lotze, M.T. (2004). Second-generation tetracycline-regulatable promoter: repositioned tet operator elements optimize transactivator synergy while shorter minimal promoter offers tight basal leakiness. J Gene Med, 6(7), 817-828.Wiley. doi: 10.1002/jgm.566.
Lotze, M.T., & Papamichail, M. (2004). A primer on cancer immunology and immunotherapy. Cancer Immunol Immunother, 53(3), 135-138.Springer Nature. doi: 10.1007/s00262-003-0467-7.
Lotze, M.T., & Rees, R.C. (2004). Identifying biomarkers and surrogates of tumors (cancer biometrics): correlation with immunotherapies and immune cells. Cancer Immunol Immunother, 53(3), 256-261.Springer Nature. doi: 10.1007/s00262-003-0487-3.
Numasaki, M., Lotze, M.T., & Sasaki, H. (2004). Interleukin-17 augments tumor necrosis factor-alpha-induced elaboration of proangiogenic factors from fibroblasts. Immunol Lett, 93(1), 39-43.Elsevier. doi: 10.1016/j.imlet.2004.01.014.
Vakkila, J., & Lotze, M.T. (2004). Inflammation and necrosis promote tumour growth. Nat Rev Immunol, 4(8), 641-648.Springer Nature. doi: 10.1038/nri1415.
Vakkila, J., DeMarco, R.A., & Lotze, M.T. (2004). Imaging analysis of STAT1 and NF-kappaB translocation in dendritic cells at the single cell level. J Immunol Methods, 294(1-2), 123-134.Elsevier. doi: 10.1016/j.jim.2004.09.007.
Yu, J., Lu, Y., Zhu, W., Wang, Y., Chen, X., Yi, C., Luo, D., Lotze, M.T., & Zhou, Q. (2004). [Anti-tumor activities of lung cancer dendritic cell vaccine modified by mutant Ki-ras gene in vitro]. Zhongguo Fei Ai Za Zhi, 7(2), 104-107. doi: 10.3779/j.issn.1009-3419.2004.02.06.
Eto, M., Bennouna, J., Hunter, O.C., Hershberger, P.A., Kanto, T., Johnson, C.S., Lotze, M.T., & Amoscato, A.A. (2003). C16 ceramide accumulates following androgen ablation in LNCaP prostate cancer cells. Prostate, 57(1), 66-79.Wiley. doi: 10.1002/pros.10275.
Gao, W., Kumar, S., Lotze, M.T., Hanning, C., Robbins, P.D., & Gambotto, A. (2003). Innate immunity mediated by the cytokine IL-1 homologue 4 (IL-1H4/IL-1F7) induces IL-12-dependent adaptive and profound antitumor immunity. J Immunol, 170(1), 107-113.Oxford University Press (OUP). doi: 10.4049/jimmunol.170.1.107.
Hashimoto, W., Tanaka, F., Robbins, P.D., Taniguchi, M., Okamura, H., Lotze, M.T., & Tahara, H. (2003). Natural killer, but not natural killer T, cells play a necessary role in the promotion of an innate antitumor response induced by IL-18. Int J Cancer, 103(4), 508-513.Wiley. doi: 10.1002/ijc.10844.
KALINSKI, P., STORKUS, W., THOMSON, A., & LOTZE, M. (2003). Interleukin-12 Family [IL-12, 23, 12RA and 27]. In The Cytokine Handbook. (pp. 383-408).Elsevier. doi: 10.1016/b978-012689663-3/50020-x.
Kitagawa, T., Iwazawa, T., Robbins, P.D., Lotze, M.T., & Tahara, H. (2003). Advantages and limitations of particle-mediated transfection (gene gun) in cancer immuno-gene therapy using IL-10, IL-12 or B7-1 in murine tumor models. J Gene Med, 5(11), 958-965.Wiley. doi: 10.1002/jgm.441.
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Lotze, M.T. (2003). The critical need for cancer biometrics: quantitative, reproducible measures of cancer to define response to therapy. Curr Opin Investig Drugs, 4(6), 649-651.
Lotze, M.T. (2003). Editorial overview: Dealing with death: HMGB1 as a novel target for cancer therapy. Current Opinion in Investigational Drugs, 4(12), 1405-1409.
Nishioka, Y., Wen, H., Mitani, K., Robbins, P.D., Lotze, M.T., Sone, S., & Tahara, H. (2003). Differential effects of IL-12 on the generation of alloreactive CTL mediated by murine and human dendritic cells: a critical role for nitric oxide. J Leukoc Biol, 73(5), 621-629.Oxford University Press (OUP). doi: 10.1189/jlb.0402205.
Numasaki, M., Fukushi, J.I., Ono, M., Narula, S.K., Zavodny, P.J., Kudo, T., Robbins, P.D., Tahara, H., & Lotze, M.T. (2003). Interleukin-17 promotes angiogenesis and tumor growth. Blood, 101(7), 2620-2627.American Society of Hematology. doi: 10.1182/blood-2002-05-1461.
OKADA, H., BANCHEREAU, J., & LOTZE, M. (2003). Interleukin-4. In The Cytokine Handbook. (pp. 227-262).Elsevier. doi: 10.1016/b978-012689663-3/50014-4.
OKAMURA, H., LOTZE, M., TSUTSUI, H., KASHIWAMURA, S., UEDA, H., YOSHIMOTO, T., & NAKANISHI, K. (2003). Interleukin-18 [IL-1F4]. In The Cytokine Handbook. (pp. 709-733).Elsevier. doi: 10.1016/b978-012689663-3/50033-8.
Redlinger, R.E., Mailliard, R.B., Lotze, M.T., & Barksdale, E.M. (2003). Synergistic interleukin-18 and low-dose interleukin-2 promote regression of established murine neuroblastoma in vivo. J Pediatr Surg, 38(3), 301-307.Elsevier. doi: 10.1053/jpsu.2003.50098.
Son, Y.I., Dallal, R.M., & Lotze, M.T. (2003). Combined treatment with interleukin-18 and low-dose interleukin-2 induced regression of a murine sarcoma and memory response. J Immunother, 26(3), 234-240.Wolters Kluwer. doi: 10.1097/00002371-200305000-00007.
Son, Y.I., Dallal, R.M., & Lotze, M.T. (2003). Combined treatment with interleukin-18 and low-dose interleukin-2 induced regression of a murine sarcoma and memory response. Journal of Immunotherapy, 26(3), 4738.
Thomson, A.W., & Lotze, M.T. (2003). The Cytokine Handbook. 1-1396.
Dallal, R.M., Christakos, P., Lee, K., Egawa, S., Son, Y.I., & Lotze, M.T. (2002). Paucity of dendritic cells in pancreatic cancer. Surgery, 131(2), 135-138.Elsevier. doi: 10.1067/msy.2002.119937.
Jonak, Z.L., Trulli, S., Maier, C., McCabe, F.L., Kirkpatrick, R., Johanson, K., Ho, Y.S., Elefante, L., Chen, Y.J., Herzyk, D., Lotze, M.T., & Johnson, R.K. (2002). High-dose recombinant interleukin-18 induces an effective Th1 immune response to murine MOPC-315 plasmacytoma. J Immunother, 25 Suppl 1(SUPPL. 1), S20-S27.Wolters Kluwer. doi: 10.1097/00002371-200203001-00004.
Kumar, S., Hanning, C.R., Brigham-Burke, M.R., Rieman, D.J., Lehr, R., Khandekar, S., Kirkpatrick, R.B., Scott, G.F., Lee, J.C., Lynch, F.J., Gao, W., Gambotto, A., & Lotze, M.T. (2002). Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production. Cytokine, 18(2), 61-71.Elsevier. doi: 10.1006/cyto.2002.0873.
Lotze, M.T., & Kost, T.A. (2002). Viruses as gene delivery vectors: application to gene function, target validation, and assay development. Cancer Gene Ther, 9(8), 692-699.Springer Nature. doi: 10.1038/sj.cgt.7700493.
Lotze, M.T., Tahara, H., & Okamura, H. (2002). Interleukin-18 as a novel, distinct, and distant member of the interleukin-1 family promoting development of the adaptive immune response: the interleukin-18 issue of the Journal of Immunotherapy. J Immunother, 25 Suppl 1(SUPPL. 1), S1-S3.Wolters Kluwer. doi: 10.1097/00002371-200203001-00001.
Mailliard, R.B., Egawa, S., Cai, Q., Kalinska, A., Bykovskaya, S.N., Lotze, M.T., Kapsenberg, M.L., Storkus, W.J., & Kalinski, P. (2002). Complementary dendritic cell-activating function of CD8+ and CD4+ T cells: helper role of CD8+ T cells in the development of T helper type 1 responses. J Exp Med, 195(4), 473-483.Rockefeller University Press. doi: 10.1084/jem.20011662.
Odoux, C., Albers, A., Amoscato, A.A., Lotze, M.T., & Wong, M.K.K. (2002). TRAIL, FasL and a blocking anti-DR5 antibody augment paclitaxel-induced apoptosis in human non-small-cell lung cancer. Int J Cancer, 97(4), 458-465.Wiley. doi: 10.1002/ijc.1640.
Satoh, Y., Esche, C., Gambotto, A., Shurin, G.V., Yurkovetsky, Z.R., Robbins, P.D., Watkins, S.C., Todo, S., Herberman, R.B., Lotze, M.T., & Shurin, M.R. (2002). Local administration of IL-12-transfected dendritic cells induces antitumor immune responses to colon adenocarcinoma in the liver in mice. J Exp Ther Oncol, 2(6), 337-349.Wiley. doi: 10.1046/j.1359-4117.2002.01050.x.
Shimamura, H., Cumberland, R., Hiroishi, K., Watkins, S.C., Lotze, M.T., & Baar, J. (2002). Murine dendritic cell-induced tumor apoptosis is partially mediated by nitric oxide. J Immunother, 25(3), 226-234.Wolters Kluwer. doi: 10.1097/00002371-200205000-00005.
Tanaka, F., Hashimoto, W., Robbins, P.D., Lotze, M.T., & Tahara, H. (2002). Therapeutic and specific antitumor immunity induced by co-administration of immature dendritic cells and adenoviral vector expressing biologically active IL-18. Gene Ther, 9(21), 1480-1486.Springer Nature. doi: 10.1038/sj.gt.3301827.
Chi, K.H., Myers, J.N., Chow, K.C., Chan, W.K., Tsang, Y.W., Chao, Y., Yen, S.H., & Lotze, M.T. (2001). Phase II trial of systemic recombinant interleukin-2 in the treatment of refractory nasopharyngeal carcinoma. Oncology, 60(2), 110-115.Karger Publishers. doi: 10.1159/000055306.
Dallal, R.M., & Lotze, M.T. (2001). Immunotherapy of metastasis. Surg Oncol Clin N Am, 10(2), 433-xi.Elsevier. doi: 10.1016/s1055-3207(18)30074-7.
Dworacki, G., Meidenbauer, N., Kuss, I., Hoffmann, T.K., Gooding, W., Lotze, M., & Whiteside, T.L. (2001). Decreased ζ Chain Expression and Apoptosis in CD3+ Peripheral Blood T Lymphocytes of Patients with Melanoma. Clinical Cancer Research, 7(3).
Dworacki, G., Meidenbauer, N., Kuss, I., Hoffmann, T.K., Gooding, W., Lotze, M., & Whiteside, T.L. (2001). Decreased zeta chain expression and apoptosis in CD3+ peripheral blood T lymphocytes of patients with melanoma. Clinical Cancer Research, 7(3 Suppl), 947s-957s.
Dworacki, G., Meidenbauer, N., Kuss, I., Hoffmann, T.K., Gooding, W., Lotze, M., & Whiteside, T.L. (2001). Decreased zeta chain expression and apoptosis in CD3+ peripheral blood T lymphocytes of patients with melanoma. Clin Cancer Res, 7(3 Suppl), 947s-957s.
Finn, O.J., & Lotze, M.T. (2001). A decade in the life of tumor immunology. Clin Cancer Res, 7(3 Suppl), 759s-760s.
Finn, O.J., & Lotze, M.T. (2001). A Decade in the Life of Tumor Immunology. Clinical Cancer Research, 7(3).
Finn, O.J., & Lotze, M.T. (2001). A decade in the life of tumor immunology. Clinical Cancer Research, 7(11 SUPPL.).
Flaherty, L.E., Atkins, M., Sosman, J., Weiss, G., Clark, J.I., Margolin, K., Dutcher, J., Gordon, M.S., Lotze, M., Mier, J., Sorokin, P., Fisher, R.I., Appel, C., & Du, W. (2001). Outpatient biochemotherapy with interleukin-2 and interferon alfa-2b in patients with metastatic malignant melanoma: results of two phase II cytokine working group trials. J Clin Oncol, 19(13), 3194-3202.American Society of Clinical Oncology (ASCO). doi: 10.1200/JCO.2001.19.13.3194.
Fujii, S., Shimizu, K., Shimizu, T., & Lotze, M.T. (2001). Interleukin-10 promotes the maintenance of antitumor CD8(+) T-cell effector function in situ. Blood, 98(7), 2143-2151.American Society of Hematology. doi: 10.1182/blood.v98.7.2143.
Iwazawa, T., Chau, G.Y., Mori, T., Dookeran, K.A., Rubin, J.T., Watkins, S., Robbins, P.D., Lotze, M.T., & Tahara, H. (2001). Potent antitumor effects of intra-arterial injection of fibroblasts genetically engineered to express IL-12 in liver metastasis model of rat: no additional benefit of using retroviral producer cell. Cancer Gene Ther, 8(1), 17-22.Springer Nature. doi: 10.1038/sj.cgt.7700272.
Kang, W.K., Park, C., Yoon, H.L., Kim, W.S., Yoon, S.S., Lee, M.H., Park, K., Kim, K., Jeong, H.S., Kim, J.A., Nam, S.J., Yang, J.H., Son, Y.I., Baek, C.H., Han, J., Ree, H.J., Lee, E.S., Kim, S.H., Kim, D.W., Ahn, Y.C., Huh, S.J., Choe, Y.H., Lee, J.H., Park, M.H., Kong, G.S., Park, E.Y., Kang, Y.K., Bang, Y.J., Paik, N.S., Lee, S.N., Kim, S.H., Kim, S., Robbins, P.D., Tahara, H., Lotze, M.T., & Park, C.H. (2001). Interleukin 12 gene therapy of cancer by peritumoral injection of transduced autologous fibroblasts: outcome of a phase I study. Hum Gene Ther, 12(6), 671-684.Mary Ann Liebert. doi: 10.1089/104303401300057388.
Kanto, T., Kalinski, P., Hunter, O.C., Lotze, M.T., & Amoscato, A.A. (2001). Ceramide mediates tumor-induced dendritic cell apoptosis. J Immunol, 167(7), 3773-3784.Oxford University Press (OUP). doi: 10.4049/jimmunol.167.7.3773.
Mailliard, R.B., & Lotze, M.T. (2001). Dendritic cells prolong tumor-specific T-cell survival and effector function after interaction with tumor targets. Clinical Cancer Research, 7(11 SUPPL.).
Matsko, C.M., Hunter, O.C., Rabinowich, H., Lotze, M.T., & Amoscato, A.A. (2001). Mitochondrial lipid alterations during Fas- and radiation-induced apoptosis. Biochem Biophys Res Commun, 287(5), 1112-1120.Elsevier. doi: 10.1006/bbrc.2001.5696.
Okada, H., Attanucci, J., Giezeman-Smits, K.M., Brissette-Storkus, C., Fellows, W.K., Gambotto, A., Pollack, L.F., Pogue-Geile, K., Lotze, M.T., Bozik, M.E., & Chambers, W.H. (2001). Immunization with an antigen identified by cytokine tumor vaccine-assisted SEREX (CAS) suppressed growth of the rat 9L glioma in vivo. Cancer Res, 61(6), 2625-2631.
Okada, H., Villa, L., Attanucci, J., Erff, M., Fellows, W.K., Lotze, M.T., Pollack, I.F., & Chambers, W.H. (2001). Cytokine gene therapy of gliomas: effective induction of therapeutic immunity to intracranial tumors by peripheral immunization with interleukin-4 transduced glioma cells. Gene Ther, 8(15), 1157-1166.Springer Nature. doi: 10.1038/sj.gt.3301496.
Shimizu, T., Berhanu, A., Redlinger, R.E., Watkins, S., Lotze, M.T., & Barksdale, E.M. (2001). Interleukin-12 transduced dendritic cells induce regression of established murine neuroblastoma. J Pediatr Surg, 36(8), 1285-1292.Elsevier. doi: 10.1053/jpsu.2001.25796.
Shurin, G.V., Shurin, M.R., Bykovskaia, S., Shogan, J., Lotze, M.T., & Barksdale, E.M. (2001). Neuroblastoma-derived gangliosides inhibit dendritic cell generation and function. Cancer Res, 61(1), 363-369.
Son, Y.I., Dallal, R.M., Mailliard, R.B., Egawa, S., Jonak, Z.L., & Lotze, M.T. (2001). Interleukin-18 (IL-18) synergizes with IL-2 to enhance cytotoxicity, interferon-gamma production, and expansion of natural killer cells. Cancer Res, 61(3), 884-888.
Son, Y.I., Mailliard, R.B., Watkins, S.C., & Lotze, M.T. (2001). Dendritic cells pulsed with apoptotic squamous cell carcinoma have anti-tumor effects when combined with interleukin-2. Laryngoscope, 111(8), 1472-1478.Wiley. doi: 10.1097/00005537-200108000-00026.
Agha-Mohammadi, S., & Lotze, M.T. (2000). Regulatable systems: applications in gene therapy and replicating viruses. J Clin Invest, 105(9), 1177-1183.American Society for Clinical Investigation. doi: 10.1172/JCI10027.
Agha-Mohammadi, S., & Lotze, M.T. (2000). Immunomodulation of cancer: potential use of selectively replicating agents. J Clin Invest, 105(9), 1173-1176.American Society for Clinical Investigation. doi: 10.1172/JCI10026.
Dallal, R.M., & Lotze, M.T. (2000). The dendritic cell and human cancer vaccines. Curr Opin Immunol, 12(5), 583-588.Elsevier. doi: 10.1016/s0952-7915(00)00146-1.
Dutcher, J.P., Logan, T., Gordon, M., Sosman, J., Weiss, G., Margolin, K., Plasse, T., Mier, J., Lotze, M., Clark, J., & Atkins, M. (2000). Phase II trial of interleukin 2, interferon alpha, and 5-fluorouracil in metastatic renal cell cancer: a cytokine working group study. Clin Cancer Res, 6(9), 3442-3450.
Egawa, S., & Lotze, M.T. (2000). The Laheru/Jaffee article reviewed. ONCOLOGY-NEW YORK, 14(2), 259-260.
Esche, C., Cai, Q., Peron, J.M., Hunter, O., Subbotin, V.M., Lotze, M.T., & Shurin, M.R. (2000). Interleukin-12 and Flt3 ligand differentially promote dendropoiesis in vivo. European Journal of Immunology, 30(9), 2565-2575. doi: 10.1002/1521-4141(200009)30:9<2565::AID-IMMU2565>3.0.CO;2-V.
Giezeman-Smits, K.M., Okada, H., Brissette-Storkus, C.S., Villa, L.A., Attanucci, J., Lotze, M.T., Pollack, I.F., Bozik, M.E., & Chambers, W.H. (2000). Cytokine gene therapy of gliomas: induction of reactive CD4+ T cells by interleukin-4-transfected 9L gliosarcoma is essential for protective immunity. Cancer Res, 60(9), 2449-2457.
Hirao, M., Onai, N., Hiroishi, K., Watkins, S.C., Matsushima, K., Robbins, P.D., Lotze, M.T., & Tahara, H. (2000). CC chemokine receptor-7 on dendritic cells is induced after interaction with apoptotic tumor cells: critical role in migration from the tumor site to draining lymph nodes. Cancer Res, 60(8), 2209-2217.
Hiroishi, K., Tüting, T., & Lotze, M.T. (2000). IFN-α-expressing tumor cells enhance generation and promote survival of tumor-specific CTLs. Journal of Immunology, 164(2), 567-572. doi: 10.4049/jimmunol.164.2.567.
Lotze, M.T. (2000). The future role of interleukin-2 in cancer therapy. Cancer J Sci Am, 6 Suppl 1(SUPPL. 1), S58-S60.
Lotze, M.T., Shurin, M., Esche, C., Tahara, H., Storkus, W., Kirkwood, J.M., Whiteside, T.L., Elder, E.M., Okada, H., & Robbins, P. (2000). Interleukin-2: developing additional cytokine gene therapies using fibroblasts or dendritic cells to enhance tumor immunity. Cancer J Sci Am, 6 Suppl 1(SUPPL. 1), S61-S66.
Mailliard, R.B., Dallal, R.M., Son, Y.I., & Lotze, M.T. (2000). Dendritic cells promote T-cell survival or death depending upon their maturation state and presentation of antigen. Immunol Invest, 29(2), 177-185.Taylor & Francis. doi: 10.3109/08820130009062302.
Okada, H., Attanucci, J., Tahara, H., Pollack, I.F., Bozik, M.E., Chambers, W.H., & Lotze, M.T. (2000). Characterization and transduction of a retroviral vector encoding human interleukin-4 and herpes simplex virus-thymidine kinase for glioma tumor vaccine therapy. Cancer Gene Ther, 7(3), 486-494.Springer Nature. doi: 10.1038/sj.cgt.7700140.
Okada, H., Pollack, I.F., Lotze, M.T., Lunsford, L.D., Kondziolka, D., Lieberman, F., Schiff, D., Attanucci, J., Edington, H., Chambers, W., Robbins, P., Baar, J., Kinzler, D., Whiteside, T., & Elder, E. (2000). Gene therapy of malignant gliomas: a phase I study of IL-4-HSV-TK gene-modified autologous tumor to elicit an immune response. Hum Gene Ther, 11(4), 637-653.Mary Ann Liebert. doi: 10.1089/10430340050015824.
Pirtskhalaishvili, G., Shurin, G.V., Esche, C., Cai, Q., Salup, R.R., Bykovskaia, S.N., Lotze, M.T., & Shurin, M.R. (2000). Cytokine-mediated protection of human dendritic cells from prostate cancer-induced apoptosis is regulated by the Bcl-2 family of proteins. Br J Cancer, 83(4), 506-513.Springer Nature. doi: 10.1054/bjoc.2000.1289.
Ranieri, E., Kierstead, L.S., Zarour, H., Kirkwood, J.M., Lotze, M.T., Whiteside, T., & Storkus, W.J. (2000). Dendritic cell/peptide cancer vaccines: clinical responsiveness and epitope spreading. Immunol Invest, 29(2), 121-125.Taylor & Francis. doi: 10.3109/08820130009062294.
Rosenberg, S.A., Blaese, R.M., Brenner, M.K., Deisseroth, A.B., Ledley, F.D., Lotze, M.T., Wilson, J.M., Nabel, G.J., Cornetta, K., Economou, J.S., Freeman, S.M., Riddell, S.R., Brenner, M., Oldfield, E., Gansbacher, B., Dunbar, C., Walker, R.E., Schuening, F.G., Roth, J.A., Crystal, R.G., Welsh, M.J., Culver, K., Heslop, H.E., Simons, J., Wilmott, R.W., Boucher, R.C., Siegler, H.F., Barranger, J.A., Karlsson, S., Kohn, D., Galpin, J.E., Raffel, C., Hesdorffer, C., Ilan, J., Cassileth, P., O'Shaughnessy, J., Kun, L.E., Das, T.K., Wong-Staal, F., Sobol, R.E., Haubrich, R., Sznol, M., Rubin, J., Sorcher, E.J., Rosenblatt, J., Walker, R., Brigham, K., Vogelzang, N., Hersh, E., & Eck, S.L. (2000). Human gene marker/therapy clinical protocols. Hum Gene Ther, 11(6), 919-979.Mary Ann Liebert. doi: 10.1089/10430340050015536.
Saito, T., Dworacki, G., Gooding, W., Lotze, M.T., & Whiteside, T.L. (2000). Spontaneous apoptosis of CD8+ T lymphocytes in peripheral blood of patients with advanced melanoma. Clin Cancer Res, 6(4), 1351-1364.
Tanaka, F., Hashimoto, W., Okamura, H., Robbins, P.D., Lotze, M.T., & Tahara, H. (2000). Rapid generation of potent and tumor-specific cytotoxic T lymphocytes by interleukin 18 using dendritic cells and natural killer cells. Cancer Res, 60(17), 4838-4844.
Watkins, C. (2000). Preface. 21, IV.Elsevier. doi: 10.1016/b978-012455900-4/50261-0.
Weigel, T.L., Lotze, M.T., Kim, P.K., Amoscato, A.A., Luketich, J.D., & Odoux, C. (2000). Paclitaxel-induced apoptosis in non–small cell lung cancer cell lines is associated with increased caspase-3 activity. The Journal of Thoracic and Cardiovascular Surgery, 119(4), 795-803.Elsevier BV. doi: 10.1016/s0022-5223(00)70016-x.
Atkins, M.B., Lotze, M.T., Dutcher, J.P., Fisher, R.I., Weiss, G., Margolin, K., Abrams, J., Sznol, M., Parkinson, D., Hawkins, M., Paradise, C., Kunkel, L., & Rosenberg, S.A. (1999). High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993. J Clin Oncol, 17(7), 2105-2116.American Society of Clinical Oncology (ASCO). doi: 10.1200/JCO.1999.17.7.2105.
Chikamatsu, K., Nakano, K., Storkus, W.J., Appella, E., Lotze, M.T., Whiteside, T.L., & DeLeo, A.B. (1999). Generation of anti-p53 cytotoxic T lymphocytes from human peripheral blood using autologous dendritic cells. Clin Cancer Res, 5(6), 1281-1288.
Esche, C., Gambotto, A., Satoh, Y., Gerein, V., Robbins, P.D., Watkins, S.C., Lotze, M.T., & Shurin, M.R. (1999). CD154 inhibits tumor-induced apoptosis in dendritic cells and tumor growth. Eur J Immunol, 29(7), 2148-2155.Wiley. doi: 10.1002/(SICI)1521-4141(199907)29:07<2148::AID-IMMU2148>3.0.CO;2-F.
Esche, C., Lokshin, A., Shurin, G.V., Gastman, B.R., Rabinowich, H., Watkins, S.C., Lotze, M.T., & Shurin, M.R. (1999). Tumor's other immune targets: dendritic cells. J Leukoc Biol, 66(2), 336-344.Oxford University Press (OUP). doi: 10.1002/jlb.66.2.336.
Esche, C., Makarenkova, V.P., Kost, N.V., Lotze, M.T., Zozulya, A.A., & Shurin, M.R. (1999). Murine dendritic cells express functional delta-type opioid receptors. Ann N Y Acad Sci, 885(1), 387-390.Wiley. doi: 10.1111/j.1749-6632.1999.tb08695.x.
Esche, C., Shurin, M.R., & Lotze, M.T. (1999). The use of dendritic cells for cancer vaccination. Curr Opin Mol Ther, 1(1), 72-81.
Esche, C., Shurin, M.R., & Lotze, M.T. (1999). Gene therapy for melanoma. Dermatologic Therapy, 10, 74-82.
Esche, C., Subbotin, V.M., Hunter, O., Peron, J.M., Maliszewski, C., Lotze, M.T., & Shurin, M.R. (1999). Differential regulation of epidermal and dermal dendritic cells by IL-12 and Flt3 ligand. J Invest Dermatol, 113(6), 1028-1032.Elsevier. doi: 10.1046/j.1523-1747.1999.00779.x.
Gambotto, A., Tüting, T., McVey, D.L., Kovesdi, I., Tahara, H., Lotze, M.T., & Robbins, P.D. (1999). Induction of antitumor immunity by direct intratumoral injection of a recombinant adenovirus vector expressing interleukin-12. Cancer Gene Ther, 6(1), 45-53.Springer Nature. doi: 10.1038/sj.cgt.7700013.
Hashimoto, W., Osaki, T., Okamura, H., Robbins, P.D., Kurimoto, M., Nagata, S., Lotze, M.T., & Tahara, H. (1999). Differential antitumor effects of administration of recombinant IL-18 or recombinant IL-12 are mediated primarily by Fas-Fas ligand- and perforin-induced tumor apoptosis, respectively. J Immunol, 163(2), 583-589.Oxford University Press (OUP). doi: 10.4049/jimmunol.163.2.583.
Hiroishi, K., Tüting, T., Tahara, H., & Lotze, M.T. (1999). Interferon-alpha gene therapy in combination with CD80 transduction reduces tumorigenicity and growth of established tumor in poorly immunogenic tumor models. Gene Ther, 6(12), 1988-1994.Springer Nature. doi: 10.1038/sj.gt.3301034.
Lotze, M.T. (1999). In vivo veritas. Clin Immunol, 93(1), 1-4.Elsevier. doi: 10.1006/clim.1999.4786.
Lotze, M.T. (1999). Not just an antigen-presenting cell: 5th international symposium on dendritic cells in fundamental and clinical immunology. J Leukoc Biol, 66(2), 195-200.Oxford University Press (OUP). doi: 10.1002/jlb.66.2.195.
McMasters, K.M., Sondak, V.K., Lotze, M.T., & Ross, M.I. (1999). Recent advances in melanoma staging and therapy. Ann Surg Oncol, 6(5), 467-475.Springer Nature. doi: 10.1007/s10434-999-0467-8.
Muller, A., Buhn, K., Baraki, H., Lotze, M., & Becker, H. (1999). Significance of collection and clinical consequences in HNPCC-patients. Viszeralchirurgie, 34(3), 129-133.
Nishioka, Y., Hirao, M., Robbins, P.D., Lotze, M.T., & Tahara, H. (1999). Induction of systemic and therapeutic antitumor immunity using intratumoral injection of dendritic cells genetically modified to express interleukin 12. Cancer Res, 59(16), 4035-4041.
Ohm, J.E., Shurin, M.R., Esche, C., Lotze, M.T., Carbone, D.P., & Gabrilovich, D.I. (1999). Effect of vascular endothelial growth factor and FLT3 ligand on dendritic cell generation in vivo. J Immunol, 163(6), 3260-3268.Oxford University Press (OUP). doi: 10.4049/jimmunol.163.6.3260.
Okada, H., Giezeman-Smits, K.M., Tahara, H., Attanucci, J., Fellows, W.K., Lotze, M.T., Chambers, W.H., & Bozik, M.E. (1999). Effective cytokine gene therapy against an intracranial glioma using a retrovirally transduced IL-4 plus HSVtk tumor vaccine. Gene Ther, 6(2), 219-226.Springer Nature. doi: 10.1038/sj.gt.3300798.
Osaki, T., Hashimoto, W., Gambotto, A., Okamura, H., Robbins, P.D., Kurimoto, M., Lotze, M.T., & Tahara, H. (1999). Potent antitumor effects mediated by local expression of the mature form of the interferon-gamma inducing factor, interleukin-18 (IL-18). Gene Ther, 6(5), 808-815.Springer Nature. doi: 10.1038/sj.gt.3300908.
Robertson, M.J., Cameron, C., Atkins, M.B., Gordon, M.S., Lotze, M.T., Sherman, M.L., & Ritz, J. (1999). Immunological effects of interleukin 12 administered by bolus intravenous injection to patients with cancer. Clin Cancer Res, 5(1), 9-16.
Rosenberg, S.A., Blaese, R.M., Brenner, M.K., Deisseroth, A.B., Ledley, F.D., Lotze, M.T., Wilson, J.M., Nabel, G.J., Cornetta, K., Economou, J.S., Freeman, S.M., Riddell, S.R., Oldfield, E., Gansbacher, B., Dunbar, C., Walker, R.E., Schuening, F.G., Roth, J.A., Crystal, R.G., Welsh, M.J., Culver, K., Heslop, H.E., Simons, J., Wilmott, R.W., & Habib, N.A. (1999). Human gene marker/therapy clinical protocols. Hum Gene Ther, 10(18), 3067-3123.Mary Ann Liebert. doi: 10.1089/10430349950016465.
Shurin, M.R., Lu, L., Kalinski, P., Stewart-Akers, A.M., & Lotze, M.T. (1999). Th1/Th2 balance in cancer, transplantation and pregnancy. Springer Seminars in Immunopathology, 21(3), 339-359. doi: 10.1007/BF00812261.
Tanaka, F., Hirao, M., & Lotze, M.T. (1999). Delivery of dendritic cells to sites of immune reactivity. Clinical and Applied Immunology Reviews, 19(10-11), 128-131.Elsevier. doi: 10.1016/s0197-1859(00)87086-7.
Thomas, R.L., Matsko, C.M., Lotze, M.T., & Amoscato, A.A. (1999). Mass spectrometric identification of increased C16 ceramide levels during apoptosis. J Biol Chem, 274(43), 30580-30588.Elsevier. doi: 10.1074/jbc.274.43.30580.
Tüting, T., Gambotto, A., DeLeo, A., Lotze, M.T., Robbins, P.D., & Storkus, W.J. (1999). Induction of tumor antigen-specific immunity using plasmid DNA immunization in mice. Cancer Gene Ther, 6(1), 73-80.Springer Nature. doi: 10.1038/sj.cgt.7700020.
Wilson, C.C., Olson, W.C., Tuting, T., Rinaldo, C.R., Lotze, M.T., & Storkus, W.J. (1999). HIV-1-specific CTL responses primed in vitro by blood-derived dendritic cells and Th1-biasing cytokines. J Immunol, 162(5), 3070-3078.Oxford University Press (OUP). doi: 10.4049/jimmunol.162.5.3070.
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Couderc, B., Zitvogel, L., Douin-Echinard, V., Djennane, L., Tahara, H., Favre, G., Lotze, M.T., & Robbins, P.D. (1998). Enhancement of antitumor immunity by expression of CD70 (CD27 ligand) or CD154 (CD40 ligand) costimulatory molecules in tumor cells. Cancer Gene Ther, 5(3), 163-175.
Douin-Echinard, V., Robbins, P.D., Lotze, M.T., Favre, G., & Couderc, B. (1998). Enhancement of anti-tumor immunity by injection of fibroblasts genetically engineered to produce IL-12 and to express CD70. Adv Exp Med Biol, 451, 353-357.Springer Nature. doi: 10.1007/978-1-4615-5357-1_55.
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Fernandez, N., Duffour, M.T., Perricaudet, M., Lotze, M.T., Tursz, T., & Zitvogel, L. (1998). Active specific T-cell-based immunotherapy for cancer: nucleic acids, peptides, whole native proteins, recombinant viruses, with dendritic cell adjuvants or whole tumor cell-based vaccines. Principles and future prospects. Cytokines Cell Mol Ther, 4(1), 53-65.
Finn, O.J., & Lotze, M.T. (1998). Third Keystone Symposium on Cellular Immunology and the Immunotherapy of Cancer. Introduction. J Immunother, 21(2), 114-118.Wolters Kluwer. doi: 10.1097/00002371-199803000-00004.
Goldman, S.A., Baker, E., Weyant, R.J., Clarke, M.R., Myers, J.N., & Lotze, M.T. (1998). Peritumoral CD1a-positive dendritic cells are associated with improved survival in patients with tongue carcinoma. Arch Otolaryngol Head Neck Surg, 124(6), 641-646.American Medical Association (AMA). doi: 10.1001/archotol.124.6.641.
Goydos, J.S., Brumfield, A.M., Frezza, E., Booth, A., Lotze, M.T., & Carty, S.E. (1998). Marked elevation of serum interleukin-6 in patients with cholangiocarcinoma: validation of utility as a clinical marker. Ann Surg, 227(3), 398-404.Wolters Kluwer. doi: 10.1097/00000658-199803000-00012.
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Nishihara, K., Barth, R.F., Wilkie, N., Lang, J.C., Oda, Y., Kikuchi, H., Everson, M.P., & Lotze, M.T. (1995). Increased in vitro and in vivo tumoricidal activity of a macrophage cell line genetically engineered to express IFN-gamma, IL-4, IL-6, or TNF-alpha. Cancer Gene Ther, 2(2), 113-124.
Pappo, I., Tahara, H., Robbins, P.D., Gately, M.K., Wolf, S.F., Barnea, A., & Lotze, M.T. (1995). Administration of systemic or local interleukin-2 enhances the anti-tumor effects of interleukin-12 gene therapy. J Surg Res, 58(2), 218-226.Elsevier. doi: 10.1006/jsre.1995.1034.
Qin, L., Chavin, K.D., Ding, Y., Favaro, J.P., Woodward, J.E., Lin, J., Tahara, H., Robbins, P., Shaked, A., & Ho, D.Y. (1995). Multiple vectors effectively achieve gene transfer in a murine cardiac transplantation model. Immunosuppression with TGF-beta 1 or vIL-10. Transplantation, 59(6), 809-816.Wolters Kluwer. doi: 10.1097/00007890-199503270-00002.
Rubin, J.T., Day, R., Duquesnoy, R., Simonis, B., Adams, S., Lee, J., & Lotze, M.T. (1995). HLA-DQ1 is associated with clinical response and survival of patients with melanoma who are treated with interleukin-2. Ther Immunol, 2(1), 1-6.
Rubin, J.T., Lotze, M.T., Rosenfelder, D., Brumfield, A., Howells, R., Schwartz, R., Sylvestri, S., Sammon, J., Bron, K., & Orens, P. (1995). Treatment of hepatic-metastatic colorectal cancer with a chemotherapeutic emulsion: interim results of a phase I trial. Ann Surg Oncol, 2(4), 351-359.Springer Nature. doi: 10.1007/BF02307069.
Suminami, Y., Elder, E.M., Lotze, M.T., & Whiteside, T.L. (1995). In situ interleukin-4 gene expression in cancer patients treated with genetically modified tumor vaccine. J Immunother Emphasis Tumor Immunol, 17(4), 238-248.Wolters Kluwer. doi: 10.1097/00002371-199505000-00006.
Suzuki, T., Tahara, H., Narula, S., Moore, K.W., Robbins, P.D., & Lotze, M.T. (1995). Viral interleukin 10 (IL-10), the human herpes virus 4 cellular IL-10 homologue, induces local anergy to allogeneic and syngeneic tumors. J Exp Med, 182(2), 477-486.Rockefeller University Press. doi: 10.1084/jem.182.2.477.
Tahara, H., & Lotze, M.T. (1995). Antitumor effects of interleukin-12 (IL-12): applications for the immunotherapy and gene therapy of cancer. Gene Ther, 2(2), 96-106.
Tahara, H., Lotze, M.T., Robbins, P.D., Storkus, W.J., & Zitvogel, L. (1995). IL-12 gene therapy using direct injection of tumors with genetically engineered autologous fibroblasts. Hum Gene Ther, 6(12), 1607-1624.Mary Ann Liebert. doi: 10.1089/hum.1995.6.12-1607.
Tahara, H., Zitvogel, L., Storkus, W.J., Zeh, H.J., McKinney, T.G., Schreiber, R.D., Gubler, U., Robbins, P.D., & Lotze, M.T. (1995). Effective eradication of established murine tumors with IL-12 gene therapy using a polycistronic retroviral vector. J Immunol, 154(12), 6466-6474.Oxford University Press (OUP). doi: 10.4049/jimmunol.154.12.6466.
Zitvogel, L., & Lotze, M.T. (1995). Role of interleukin-12 (IL12) as an anti-tumour agent: experimental biology and clinical application. Res Immunol, 146(7-8), 628-638.Elsevier. doi: 10.1016/0923-2494(96)83041-0.
Zitvogel, L., Tahara, H., Robbins, P.D., Storkus, W.J., Clarke, M.R., Nalesnik, M.A., & Lotze, M.T. (1995). Cancer immunotherapy of established tumors with IL-12. Effective delivery by genetically engineered fibroblasts. J Immunol, 155(3), 1393-1403.Oxford University Press (OUP). doi: 10.4049/jimmunol.155.3.1393.
Di Bisceglie, A.M., Simpson, L.H., Lotze, M.T., & Hoofnagle, J.H. (1994). Development of hepatocellular carcinoma among patients with chronic liver disease due to hepatitis C viral infection. J Clin Gastroenterol, 19(3), 222-226.Wolters Kluwer. doi: 10.1097/00004836-199410000-00011.
Irshaid, Y., Adedoyin, A., Lotze, M., & Branch, R.A. (1994). Monoacetyldapsone inhibition of dapsone N-hydroxylation by human and rat liver microsomes. Drug Metab Dispos, 22(1), 161-164.Elsevier. doi: 10.1016/s0090-9556(25)08292-3.
Itoh, T., Storkus, W.J., Gorelik, E., & Lotze, M.T. (1994). Partial purification of murine tumor-associated peptide epitopes common to histologically distinct tumors, melanoma and sarcoma, that are presented by H-2Kb molecules and recognized by CD8+ tumor-infiltrating lymphocytes. J Immunol, 153(3), 1202-1215.Oxford University Press (OUP). doi: 10.4049/jimmunol.153.3.1202.
Leder, G.H., Storkus, W.J., Stuber, G., Modrow, S., & Lotze, M.T. (1994). Erratum: (Langenbecks Archiv fur Chirurgie, Forumband 1994). Langenbecks Archiv fur Chirurgie, 379(4), 254.
Lotze, M.T. (1994). Molecular biology and clinical applications to cancer. Curr Opin Gen Surg, 245-254.
Lotze, M.T., Agarwala, S.S., & Kirkwood, J.M. (1994). Clinical applications of IL-2: Commentary I. ONCOLOGY, 8(6).
Lotze, M.T., Rubin, J.T., Carty, S., Edington, H., Ferson, P., Landreneau, R., Pippin, B., Posner, M., Rosenfelder, D., & Watson, C. (1994). Gene therapy of cancer: a pilot study of IL-4-gene-modified fibroblasts admixed with autologous tumor to elicit an immune response. Hum Gene Ther, 5(1), 41-55.Mary Ann Liebert. doi: 10.1089/hum.1994.5.1-41.
Nastala, C.L., Edington, H.D., McKinney, T.G., Tahara, H., Nalesnik, M.A., Brunda, M.J., Gately, M.K., Wolf, S.F., Schreiber, R.D., & Storkus, W.J. (1994). Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production. J Immunol, 153(4), 1697-1706.Oxford University Press (OUP). doi: 10.4049/jimmunol.153.4.1697.
Oppenheim, M.H., & Lotze, M.T. (1994). lnterleukin-2: Solid-Tumor Therapy. Oncology, 51(2), 154-169.S. Karger AG. doi: 10.1159/000227330.
Pippin, B.A., Rosenstein, M., Jacob, W.F., Chiang, Y., & Lotze, M.T. (1994). Local IL-4 delivery enhances immune reactivity to murine tumors: gene therapy in combination with IL-2. Cancer Gene Ther, 1(1), 35-42.
Pockaj, B.A., Yang, J.C., Lotze, M.T., Lange, J.R., Spencer, W.F., Steinberg, S.M., Topalian, S.L., Schwartzentruber, D.J., White, D.E., & Rosenberg, S.A. (1994). A prospective randomized trial evaluating colloid versus crystalloid resuscitation in the treatment of the vascular leak syndrome associated with interleukin-2 therapy. J Immunother Emphasis Tumor Immunol, 15(1), 22-28.Wolters Kluwer. doi: 10.1097/00002371-199401000-00003.
Robbins, P.D., Tahara, H., Mueller, G., Hung, G., Bahnson, A., Zitvogel, L., Galea-Lauri, J., Ohashi, T., Patrene, K., & Boggs, S.S. (1994). Retroviral vectors for use in human gene therapy for cancer, Gaucher disease, and arthritis. Ann N Y Acad Sci, 716(1), 72-88.Wiley. doi: 10.1111/j.1749-6632.1994.tb21704.x.
Schwarz, R.E., Reynolds, J.C., & Lotze, M.T. (1994). "Pseudo-pseudotumor" of the liver. Adenocarcinoma presenting as an inflammatory pseudotumor. Dig Dis Sci, 39(12), 2679-2684.Springer Nature. doi: 10.1007/BF02087709.
Strumph, P.S., Carty, S.E., Rilo, H.L., Carroll, P.B., Ricordi, C., & Lotze, M.T. (1994). Interleukin-1 receptor antagonist is not detrimental to human islet cell insulin secretion but decreases insulin content. Transplant Proc, 26(2), 694.
Stuber, G., Leder, G.H., Storkus, W.T., Lotze, M.T., Modrow, S., Székely, L., Wolf, H., Klein, E., Kärre, K., & Klein, G. (1994). Identification of wild-type and mutant p53 peptides binding to HLA-A2 assessed by a peptide loading-deficient cell line assay and a novel major histocompatibility complex class I peptide binding assay. Eur J Immunol, 24(3), 765-768.Wiley. doi: 10.1002/eji.1830240341.
Tahara, H., Zeh, H.J., Storkus, W.J., Pappo, I., Watkins, S.C., Gubler, U., Wolf, S.F., Robbins, P.D., & Lotze, M.T. (1994). Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo. Cancer Res, 54(1), 182-189.
Zeh, H.J., Leder, G.H., Lotze, M.T., Salter, R.D., Tector, M., Stuber, G., Modrow, S., & Storkus, W.J. (1994). Flow-cytometric determination of peptide-class I complex formation. Identification of p53 peptides that bind to HLA-A2. Hum Immunol, 39(2), 79-86.Elsevier. doi: 10.1016/0198-8859(94)90105-8.
Zitvogel, L., Tahara, H., Cai, Q., Storkus, W.J., Muller, G., Wolf, S.F., Gately, M., Robbins, P.D., & Lotze, M.T. (1994). Construction and characterization of retroviral vectors expressing biologically active human interleukin-12. Hum Gene Ther, 5(12), 1493-1506.Mary Ann Liebert. doi: 10.1089/hum.1994.5.12-1493.
Hunt, J.D., Pippin, B.A., Landreneau, R.J., Jacob, W.F., Lotze, M.T., & Siegfried, J.M. (1993). Transfer and expression of the human interleukin-4 gene in carcinoma and stromal cell lines derived from lung cancer patients. J Immunother Emphasis Tumor Immunol, 14(4), 314-321.Wolters Kluwer. doi: 10.1097/00002371-199311000-00011.
Kawakami, Y., Haas, G.P., & Lotze, M.T. (1993). Expansion of tumor-infiltrating lymphocytes from human tumors using the T-cell growth factors interleukin-2 and interleukin-4. J Immunother Emphasis Tumor Immunol, 14(4), 336-347.Wolters Kluwer. doi: 10.1097/00002371-199311000-00014.
LOTZE, M.T. (1993). TRANSPLANTATION AND ADOPTIVE CELLULAR THERAPY OF CANCER - THE ROLE OF T-CELL GROWTH-FACTORS. CELL TRANSPLANTATION, 2(1), 33-47.SAGE Publications. doi: 10.1177/096368979300200106.
Lotze, M.T., & Finn, O.J. (1993). Introduction: Report on the keystone symposium: Cellular immunity and the immunotherapy of cancer II. Journal of Immunotherapy, 14(2), 79-87. doi: 10.1097/00002371-199308000-00001.
Miller, D.L., & Lotze, M.T. (1993). A plea for a standard standard. Radiology, 188(1), 19-20.Radiological Society of North America (RSNA). doi: 10.1148/radiology.188.1.8390068.
Rosenberg, S.A., Lotze, M.T., & Yang, J.C. (1993). Erratum: Prospective randomized trial of high-dose interleukin-2 alone or in conjunction with lymphokine-activated killer cells for the treatment of patients with advanced cancer (J Natl Cancer Inst (1993) 85 (622-632)). Journal of the National Cancer Institute, 85(13), 1091.
Rosenberg, S.A., Lotze, M.T., Yang, J.C., Topalian, S.L., Chang, A.E., Schwartzentruber, D.J., Aebersold, P., Leitman, S., Linehan, W.M., & Seipp, C.A. (1993). Prospective randomized trial of high-dose interleukin-2 alone or in conjunction with lymphokine-activated killer cells for the treatment of patients with advanced cancer. J Natl Cancer Inst, 85(8), 622-632.Oxford University Press (OUP). doi: 10.1093/jnci/85.8.622.
Storkus, W.J., Zeh, H.J., Maeurer, M.J., Salter, R.D., & Lotze, M.T. (1993). Identification of human melanoma peptides recognized by class I restricted tumor infiltrating T lymphocytes. J Immunol, 151(7), 3719-3727.Oxford University Press (OUP). doi: 10.4049/jimmunol.151.7.3719.
Storkus, W.J., Zeh, H.J., Salter, R.D., & Lotze, M.T. (1993). Identification of T-cell epitopes: rapid isolation of class I-presented peptides from viable cells by mild acid elution. J Immunother Emphasis Tumor Immunol, 14(2), 94-103.Wolters Kluwer. doi: 10.1097/00002371-199308000-00003.
Weidmann, E., Elder, E.M., Trucco, M., Lotze, M.T., & Whiteside, T.L. (1993). Usage of T-cell receptor V beta chain genes in fresh and cultured tumor-infiltrating lymphocytes from human melanoma. Int J Cancer, 54(3), 383-390.Wiley. doi: 10.1002/ijc.2910540306.
Wong, H.L., Costa, G.L., Lotze, M.T., & Wahl, S.M. (1993). Interleukin (IL) 4 differentially regulates monocyte IL-1 family gene expression and synthesis in vitro and in vivo. J Exp Med, 177(3), 775-781.Rockefeller University Press. doi: 10.1084/jem.177.3.775.
Zeh, H.J., Hurd, S., Storkus, W.J., & Lotze, M.T. (1993). Interleukin-12 promotes the proliferation and cytolytic maturation of immune effectors: implications for the immunotherapy of cancer. J Immunother Emphasis Tumor Immunol, 14(2), 155-161.Wolters Kluwer. doi: 10.1097/00002371-199308000-00012.
Choyke, P.L., Miller, D.L., Lotze, M.T., Whiteis, J.M., Ebbitt, B., & Rosenberg, S.A. (1992). Delayed reactions to contrast media after interleukin-2 immunotherapy. Radiology, 183(1), 111-114.Radiological Society of North America (RSNA). doi: 10.1148/radiology.183.1.1549655.
Emery, B.E., White, M.V., Igarashi, Y., Mullol, J., Berkebile, C., Peden, D., Lotze, M.T., & Kaliner, M.A. (1992). The effect of IL-4 on human nasal mucosal responses. J Allergy Clin Immunol, 90(5), 772-781.Elsevier. doi: 10.1016/0091-6749(92)90101-7.
Lange, J.R., Raubitschek, A.A., Pockaj, B.A., Spencer, W.F., Lotze, M.T., Topalian, S.L., Yang, J.C., & Rosenberg, S.A. (1992). A pilot study of the combination of interleukin-2-based immunotherapy and radiation therapy. J Immunother (1991), 12(4), 265-271.Wolters Kluwer. doi: 10.1097/00002371-199211000-00007.
LOTZE, M.T. (1992). PAPERS FROM THE 1992 KEYSTONE SYMPOSIUM ON MELANOMA AND BIOLOGY OF THE NEURAL CREST - INTRODUCTION. JOURNAL OF IMMUNOTHERAPY, 12(3), 153.Wolters Kluwer. doi: 10.1097/00002371-199210000-00001.
Lotze, M.T., Rubin, J.T., & Zeh, H.J. (1992). New biologic agents come to bat for cancer therapy. Curr Opin Oncol, 4(6), 1116-1123.Wolters Kluwer. doi: 10.1097/00001622-199212000-00017.
Lotze, M.T., Zeh, H.J., Elder, E.M., Cai, Q., Pippin, B.A., Rosenstein, M.M., Whiteside, T.L., & Herberman, R. (1992). Use of T-cell growth factors (interleukins 2, 4, 7, 10, and 12) in the evaluation of T-cell reactivity to melanoma. J Immunother (1991), 12(3), 212-217.Wolters Kluwer. doi: 10.1097/00002371-199210000-00015.
Marincola, F.M., Venzon, D., White, D., Rubin, J.T., Lotze, M.T., Simonis, T.B., Balkissoon, J., Rosenberg, S.A., & Parkinson, D.R. (1992). HLA association with response and toxicity in melanoma patients treated with interleukin 2-based immunotherapy. Cancer Res, 52(23), 6561-6566.
Rubin, J.T., & Lotze, M.T. (1992). Immune function and dysfunction. A primer for the radiologist. Radiol Clin North Am, 30(3), 507-523.Elsevier. doi: 10.1016/s0033-8389(22)02507-6.
Rubin, J.T., & Lotze, M.T. (1992). Acute gastric mucosal injury associated with the systemic administration of interleukin-4. Surgery, 111(3), 274-280.
Sanda, M.G., Yang, J.C., Topalian, S.L., Groves, E.S., Childs, A., Belfort, R., de Smet, M.D., Schwartzentruber, D.J., White, D.E., & Lotze, M.T. (1992). Intravenous administration of recombinant human macrophage colony-stimulating factor to patients with metastatic cancer: a phase I study. J Clin Oncol, 10(10), 1643-1649.American Society of Clinical Oncology (ASCO). doi: 10.1200/JCO.1992.10.10.1643.
Spencer, W.F., Linehan, W.M., Walther, M.M., Haas, G.P., Lotze, M.T., Topalian, S.L., Yang, J.C., Merino, M.J., Lange, J.R., & Pockaj, B.A. (1992). Immunotherapy with interleukin-2 and alpha-interferon in patients with metastatic renal cell cancer with in situ primary cancers: a pilot study. J Urol, 147(1), 24-30.Wolters Kluwer. doi: 10.1016/s0022-5347(17)37124-0.
Tahara, H., Mueller, G.M., Ricordi, C., Robbins, P.D., & Lotze, M.T. (1992). Islet cell transplantation facilitated by gene transfer. Transplant Proc, 24(6), 2975-2976.
White, M.V., Igarashi, Y., Emery, B.E., Lotze, M.T., & Kaliner, M.A. (1992). Effects of in vivo administration of interleukin-2 (IL-2) and IL-4, alone and in combination, on ex vivo human basophil histamine release. Blood, 79(6), 1491-1495.American Society of Hematology. doi: 10.1182/blood.V79.6.1491.bloodjournal7961491.
Wong, H.L., Lotze, M.T., Wahl, L.M., & Wahl, S.M. (1992). Administration of recombinant IL-4 to humans regulates gene expression, phenotype, and function in circulating monocytes. J Immunol, 148(7), 2118-2125.Oxford University Press (OUP). doi: 10.4049/jimmunol.148.7.2118.
Culver, K., Cornetta, K., Morgan, R., Morecki, S., Aebersold, P., Kasid, A., Lotze, M., Rosenberg, S.A., Anderson, W.F., & Blaese, R.M. (1991). Lymphocytes as cellular vehicles for gene therapy in mouse and man. Proc Natl Acad Sci U S A, 88(8), 3155-3159.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.88.8.3155.
Lotze, M.T. (1991). Trials and tribulations: the cost of developing gene therapies. FASEB J, 5(15), 3013-3014.Wiley. doi: 10.1096/fasebj.5.15.1743433.
Lotze, M.T. (1991). Concerning repeat hepatic resections for colorectal metastases [4]. Surgery, 109(3 I), 347-348.
Stötter, H., & Lotze, M.T. (1991). Human lymphokine-activated killer cell activity. Role of IL-2, IL-4, and IL-7. Arch Surg, 126(12), 1525-1530.American Medical Association (AMA). doi: 10.1001/archsurg.1991.01410360099017.
Stötter, H., Custer, M.C., Bolton, E.S., Guedez, L., & Lotze, M.T. (1991). IL-7 induces human lymphokine-activated killer cell activity and is regulated by IL-4. J Immunol, 146(1), 150-155.Oxford University Press (OUP). doi: 10.4049/jimmunol.146.1.150.
Bock, S.N., Lee, R.E., Fisher, B., Rubin, J.T., Schwartzentruber, D.J., Wei, J.P., Callender, D.P., Yang, J.C., Lotze, M.T., & Pizzo, P.A. (1990). A prospective randomized trial evaluating prophylactic antibiotics to prevent triple-lumen catheter-related sepsis in patients treated with immunotherapy. J Clin Oncol, 8(1), 161-169.American Society of Clinical Oncology (ASCO). doi: 10.1200/JCO.1990.8.1.161.
Custer, M.C., & Lotze, M.T. (1990). A biologic assay for IL-4. Rapid fluorescence assay for IL-4 detection in supernatants and serum. J Immunol Methods, 128(1), 109-117.Elsevier. doi: 10.1016/0022-1759(90)90469-c.
Jablons, D., Bolton, E., Mertins, S., Rubin, M., Pizzo, P., Rosenberg, S.A., & Lotze, M.T. (1990). IL-2-based immunotherapy alters circulating neutrophil Fc receptor expression and chemotaxis. J Immunol, 144(9), 3630-3636.Oxford University Press (OUP). doi: 10.4049/jimmunol.144.9.3630.
Jablons, D.M., Donohue, R., Kawakami, Y., Young, J.D., & Lotze, M.T. (1990). Interleukin-3 induces proliferation but not lymphokine activated killer activity from human and murine mononuclear cells. Eur Cytokine Netw, 1(2), 91-98.
Kasid, A., Director, E.P., Stovroff, M.C., Lotze, M.T., & Rosenberg, S.A. (1990). Cytokine regulation of tumor necrosis factor-alpha and -beta (lymphotoxin)-messenger RNA expression in human peripheral blood mononuclear cells. Cancer Res, 50(16), 5072-5076.
Kasid, A., Morecki, S., Aebersold, P., Cornetta, K., Culver, K., Freeman, S., Director, E., Lotze, M.T., Blaese, R.M., & Anderson, W.F. (1990). Human gene transfer: characterization of human tumor-infiltrating lymphocytes as vehicles for retroviral-mediated gene transfer in man. Proc Natl Acad Sci U S A, 87(1), 473-477.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.87.1.473.
Kragel, A.H., Travis, W.D., Feinberg, L., Pittaluga, S., Striker, L.M., Roberts, W.C., Lotze, M.T., Yang, J.J., & Rosenberg, S.A. (1990). Pathologic findings associated with interleukin-2-based immunotherapy for cancer: a postmortem study of 19 patients. Hum Pathol, 21(5), 493-502.Elsevier. doi: 10.1016/0046-8177(90)90005-p.
Laue, L., Lotze, M.T., Chrousos, G.P., Barnes, K., Loriaux, D.L., & Fleisher, T.A. (1990). Effect of chronic treatment with the glucocorticoid antagonist RU 486 in man: toxicity, immunological, and hormonal aspects. J Clin Endocrinol Metab, 71(6), 1474-1480.The Endocrine Society. doi: 10.1210/jcem-71-6-1474.
Lotze, M.T., & Finn, O.J. (1990). Recent advances in cellular immunology: implications for immunity to cancer. Immunol Today, 11(6), 190-193.Elsevier. doi: 10.1016/0167-5699(90)90079-o.
Lotze, M.T., & Finn, O.J. (1990). Recent advances in cellular immunology: implications for immunity to cancer. Immunology Today, 11(C), 190-193. doi: 10.1016/0167-5699(90)90079-o.
Lotze, M.T., Custer, M.C., Bolton, E.S., Wiebke, E.A., Kawakami, Y., & Rosenberg, S.A. (1990). Mechanisms of immunologic antitumor therapy: lessons from the laboratory and clinical applications. Hum Immunol, 28(2), 198-207.Elsevier. doi: 10.1016/0198-8859(90)90020-p.
Rosenberg, S.A., Aebersold, P., Cornetta, K., Kasid, A., Morgan, R.A., Moen, R., Karson, E.M., Lotze, M.T., Yang, J.C., & Topalian, S.L. (1990). Gene transfer into humans--immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction. N Engl J Med, 323(9), 570-578.Massachusetts Medical Society. doi: 10.1056/NEJM199008303230904.
Stötter, H., & Lotze, M.T. (1990). Cytolytic effector cells against human tumors: distinguishing phenotype and function. Cancer Cells, 2(2), 44-55.
Ward, B., McGarvey, C., & Lotze, M.T. (1990). Excellent shoulder function is attainable after partial or total scapulectomy. Analysis at prolonged follow-up. Arch Surg, 125(4), 537-542.American Medical Association (AMA). doi: 10.1001/archsurg.1990.01410160125024.
Wiebke, E.A., Custer, M.C., Rosenberg, S.A., & Lotze, M.T. (1990). Cytokines alter target cell susceptibility to lysis: I. Evaluation of non-major histocompatibility complex-restricted effectors reveals differential effects on natural and lymphokine-activated killing. J Biol Response Mod, 9(2), 113-126.
Del Vecchio, S., Reynolds, J.C., Carrasquillo, J.A., Blasberg, R.G., Neumann, R.D., Lotze, M.T., Bryant, G.J., Farkas, R.J., & Larson, S.M. (1989). Local distribution and concentration of intravenously injected 131I-9.2.27 monoclonal antibody in human malignant melanoma. Cancer Res, 49(10), 2783-2789.
Denicoff, K.D., Durkin, T.M., Lotze, M.T., Quinlan, P.E., Davis, C.L., Listwak, S.J., Rosenberg, S.A., & Rubinow, D.R. (1989). The neuroendocrine effects of interleukin-2 treatment. J Clin Endocrinol Metab, 69(2), 402-410.The Endocrine Society. doi: 10.1210/jcem-69-2-402.
Fisher, B., Keenan, A.M., Garra, B.S., Steinberg, S.M., White, D.E., DiBisceglie, A.M., Hoofnagle, J.H., Yolles, P., Rosenberg, S.A., & Lotze, M.T. (1989). Interleukin-2 induces profound reversible cholestasis: a detailed analysis in treated cancer patients. J Clin Oncol, 7(12), 1852-1862.American Society of Clinical Oncology (ASCO). doi: 10.1200/JCO.1989.7.12.1852.
Jablons, D.M., McIntosh, J.K., Mulé, J.J., Nordan, R.P., Rudikoff, S., & Lotze, M.T. (1989). Induction of interferon-beta 2/interleukin-6 (IL-6) by cytokine administration and detection of circulating interleukin-6 in the tumor-bearing state. Ann N Y Acad Sci, 557(1), 157-160.Wiley. doi: 10.1111/j.1749-6632.1989.tb24008.x.
Jablons, D.M., Mule, J.J., McIntosh, J.K., Sehgal, P.B., May, L.T., Huang, C.M., Rosenberg, S.A., & Lotze, M.T. (1989). IF-6/IFN-β2 as a circulating hormone: Induction by cytokine administration in humans. Journal of Immunology, 142(5), 1542-1547.
Kawakami, Y., Custer, M.C., Rosenberg, S.A., & Lotze, M.T. (1989). IL-4 regulates IL-2 induction of lymphokine-activated killer activity from human lymphocytes. J Immunol, 142(10), 3452-3461.Oxford University Press (OUP). doi: 10.4049/jimmunol.142.10.3452.
Lee, R.E., Lotze, M.T., Skibber, J.M., Tucker, E., Bonow, R.O., Ognibene, F.P., Carrasquillo, J.A., Shelhamer, J.H., Parrillo, J.E., & Rosenberg, S.A. (1989). Cardiorespiratory effects of immunotherapy with interleukin-2. J Clin Oncol, 7(1), 7-20.American Society of Clinical Oncology (ASCO). doi: 10.1200/JCO.1989.7.1.7.
Lotze, M. (1989). Disturbing homeostasis: recent results of ongoing immunotherapy trials at the NCI. Biotechnol Ther, 1(2), 125-162.
LOTZE, M.T. (1989). High-output cardiac failure in multiple myeloma. N Engl J Med, 320(21), 1419-1420.Massachusetts Medical Society. doi: 10.1056/NEJM198905253202116.
McIntosh, J.K., Jablons, D.M., Mulé, J.J., Nordan, R.P., Rudikoff, S., Lotze, M.T., & Rosenberg, S.A. (1989). In vivo induction of IL-6 by administration of exogenous cytokines and detection of de novo serum levels of IL-6 in tumor-bearing mice. J Immunol, 143(1), 162-167.Oxford University Press (OUP). doi: 10.4049/jimmunol.143.1.162.
MCINTOSH, J.K., MULE, J.J., JABLONS, D.M., NORDAN, R.P., RUDIKOFF, S., LOTZE, M.T., & ROSENBERG, S.A. (1989). THE KINETICS OF INTERLEUKIN-6 INDUCTION BY THE SYSTEMIC ADMINISTRATION OF RHTNF-ALPHA IN MICE. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 557(1), 572-575.Wiley. doi: 10.1111/j.1749-6632.1989.tb24070.x.
Rosenberg, S.A., Lotze, M.T., Yang, J.C., Aebersold, P.M., Linehan, W.M., Seipp, C.A., & White, D.E. (1989). Experience with the use of high-dose interleukin-2 in the treatment of 652 cancer patients. Ann Surg, 210(4), 474-484.Wolters Kluwer. doi: 10.1097/00000658-198910000-00008.
Rosenberg, S.A., Lotze, M.T., Yang, J.C., Linehan, W.M., Seipp, C., Calabro, S., Karp, S.E., Sherry, R.M., Steinberg, S., & White, D.E. (1989). Combination therapy with interleukin-2 and alpha-interferon for the treatment of patients with advanced cancer. J Clin Oncol, 7(12), 1863-1874.American Society of Clinical Oncology (ASCO). doi: 10.1200/JCO.1989.7.12.1863.
Rubin, J.T., Elwood, L.J., Rosenberg, S.A., & Lotze, M.T. (1989). Immunohistochemical correlates of response to recombinant interleukin-2-based immunotherapy in humans. Cancer Res, 49(24 Pt 1), 7086-7092.
Sakahara, H., Reynolds, J.C., Carrasquillo, J.A., Lora, M.E., Maloney, P.J., Lotze, M.T., Larson, S.M., & Neumann, R.D. (1989). In vitro complex formation and biodistribution of mouse antitumor monoclonal antibody in cancer patients. J Nucl Med, 30(8), 1311-1317.
Stötter, H., Wiebke, E.A., Tomita, S., Belldegrun, A., Topalian, S., Rosenberg, S.A., & Lotze, M.T. (1989). Cytokines alter target cell susceptibility to lysis. II. Evaluation of tumor infiltrating lymphocytes. J Immunol, 142(5), 1767-1773.Oxford University Press (OUP). doi: 10.4049/jimmunol.142.5.1767.
Begley, M.G., Shawker, T.H., Robertson, C.N., Bock, S.N., Wei, J.P., & Lotze, M.T. (1988). Fournier gangrene: diagnosis with scrotal US. Radiology, 169(2), 387-389.Radiological Society of North America (RSNA). doi: 10.1148/radiology.169.2.3051115.
Chang, A.E., Kinsella, T., Glatstein, E., Baker, A.R., Sindelar, W.F., Lotze, M.T., Danforth, D.N., Sugarbaker, P.H., Lack, E.E., & Steinberg, S.M. (1988). Adjuvant chemotherapy for patients with high-grade soft-tissue sarcomas of the extremity. J Clin Oncol, 6(9), 1491-1500.American Society of Clinical Oncology (ASCO). doi: 10.1200/JCO.1988.6.9.1491.
Cotran, R.S., Pober, J.S., Gimbrone, M.A., Springer, T.A., Wiebke, E.A., Gaspari, A.A., Rosenberg, S.A., & Lotze, M.T. (1988). Endothelial activation during interleukin 2 immunotherapy. A possible mechanism for the vascular leak syndrome. J Immunol, 140(6), 1883-1888.Oxford University Press (OUP). doi: 10.4049/jimmunol.140.6.1883.
Di Bisceglie, A.M., Rustgi, V.K., Hoofnagle, J.H., Dusheiko, G.M., & Lotze, M.T. (1988). NIH conference. Hepatocellular carcinoma. Ann Intern Med, 108(3), 390-401.American College of Physicians. doi: 10.7326/0003-4819-108-3-390.
Jablons, D.M., & Lotze, M.T. (1988). Derivation of cells with lytic activity against fresh and cultured tumors from human bone marrow. J Surg Res, 44(4), 404-416.Elsevier. doi: 10.1016/0022-4804(88)90183-7.
Kawakami, Y., Rosenberg, S.A., & Lotze, M.T. (1988). Interleukin 4 promotes the growth of tumor-infiltrating lymphocytes cytotoxic for human autologous melanoma. J Exp Med, 168(6), 2183-2191.Rockefeller University Press. doi: 10.1084/jem.168.6.2183.
Lee, R.E. (1988). Interleukin 2 and Psoriasis. Archives of Dermatology, 124(12), 1811.American Medical Association (AMA). doi: 10.1001/archderm.1988.01670120027005.
Lotze, M.T., & Rosenberg, S.A. (1988). The immunologic treatment of cancer. CA Cancer J Clin, 38(2), 68-94.Wiley. doi: 10.3322/canjclin.38.2.68.
Lotze, M.T., Ross, W.G., Tomita, S., & Custer, M.C. (1988). Cells invading tumors: strategies for the identification and expansion of tumor reactive lymphocytes. Transplant Proc, 20(2), 326-331.
Ognibene, F.P., Rosenberg, S.A., Lotze, M., Skibber, J., Parker, M.M., Shelhamer, J.H., & Parrillo, J.E. (1988). Interleukin-2 administration causes reversible hemodynamic changes and left ventricular dysfunction similar to those seen in septic shock. Chest, 94(4), 750-754.Elsevier. doi: 10.1378/chest.94.4.750.
Rizzoni, W.E., Miller, K., Rick, M., & Lotze, M.T. (1988). Heparin-induced thrombocytopenia and thromboembolism in the postoperative period. Surgery, 103(4), 470-476.
Roberts, K., & Lotze, M.T. (1988). Interleukin 2 promotes conjugate formation by purified LAK precursors and T lymphocytes: evaluation of conjugates using flow cytometric techniques. J Biol Response Mod, 7(3), 249-266.
Rosenberg, S.A., Lotze, M.T., & Mulé, J.J. (1988). NIH conference. New approaches to the immunotherapy of cancer using interleukin-2. Ann Intern Med, 108(6), 853-864.American College of Physicians. doi: 10.7326/0003-4819-108-6-853.
Rosenberg, S.A., Packard, B.S., Aebersold, P.M., Solomon, D., Topalian, S.L., Toy, S.T., Simon, P., Lotze, M.T., Yang, J.C., & Seipp, C.A. (1988). Use of tumor-infiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma. A preliminary report. N Engl J Med, 319(25), 1676-1680.Massachusetts Medical Society. doi: 10.1056/NEJM198812223192527.
Schwartzentruber, D., Lotze, M.T., & Rosenberg, S.A. (1988). Colonic perforation: An unusual complication of therapy with high‐dose lnterleukin‐2. Cancer, 62(11), 2350-2353. doi: 10.1002/1097-0142(19881201)62:11<2350::AID-CNCR2820621116>3.0.CO;2-S.
Topalian, S.L., Solomon, D., Avis, F.P., Chang, A.E., Freerksen, D.L., Linehan, W.M., Lotze, M.T., Robertson, C.N., Seipp, C.A., & Simon, P. (1988). Immunotherapy of patients with advanced cancer using tumor-infiltrating lymphocytes and recombinant interleukin-2: a pilot study. J Clin Oncol, 6(5), 839-853.American Society of Clinical Oncology (ASCO). doi: 10.1200/JCO.1988.6.5.839.
Wiebke, E.A., Rosenberg, S.A., & Lotze, M.T. (1988). Acute immunologic effects of interleukin-2 therapy in cancer patients: decreased delayed type hypersensitivity response and decreased proliferative response to soluble antigens. J Clin Oncol, 6(9), 1440-1449.American Society of Clinical Oncology (ASCO). doi: 10.1200/JCO.1988.6.9.1440.
Cohen, P.J., Lotze, M.T., Roberts, J.R., Rosenberg, S.A., & Jaffe, E.S. (1987). The immunopathology of sequential tumor biopsies in patients treated with interleukin-2. Correlation of response with T-cell infiltration and HLA-DR expression. Am J Pathol, 129(2), 208-216.
Denicoff, K.D., Rubinow, D.R., Papa, M.Z., Simpson, C., Seipp, C.A., Lotze, M.T., Chang, A.E., Rosenstein, D., & Rosenberg, S.A. (1987). The neuropsychiatric effects of treatment with interleukin-2 and lymphokine-activated killer cells. Ann Intern Med, 107(3), 293-300.American College of Physicians. doi: 10.7326/0003-4819-107-2-293.
Edington, H.D., & Lotze, M.T. (1987). V-Y closure for abdominal wall stomal reduction. Surg Gynecol Obstet, 164(4), 381-382.
Gaspari, A.A. (1987). Dermatologic Changes Associated With Interleukin 2 Administration. JAMA: The Journal of the American Medical Association, 258(12), 1624.American Medical Association (AMA). doi: 10.1001/jama.1987.03400120074028.
Lotze, M.T., & Rosenberg, S.A. (1987). In Reply. JAMA: The Journal of the American Medical Association, 257(13), 1730-1731. doi: 10.1001/jama.1987.03390130047019.
Lotze, M.T., Custer, M.C., Sharrow, S.O., Rubin, L.A., Nelson, D.L., & Rosenberg, S.A. (1987). In vivo administration of purified human interleukin-2 to patients with cancer: development of interleukin-2 receptor positive cells and circulating soluble interleukin-2 receptors following interleukin-2 administration. Cancer Res, 47(8), 2188-2195.
Lotze, M.T., Roberts, K., Custer, M.C., Segal, D.A., & Rosenberg, S.A. (1987). Specific binding and lysis of human melanoma by IL-2-activated cells coated with anti-T3 or anti-Fc receptor cross-linked to antimelanoma antibody: a possible approach to the immunotherapy of human tumors. J Surg Res, 42(5), 580-589.Elsevier. doi: 10.1016/0022-4804(87)90036-9.
Roberts, K., Lotze, M.T., & Rosenberg, S.A. (1987). Separation and functional studies of the human lymphokine-activated killer cell. Cancer Res, 47(16), 4366-4371.
Rosenberg, S.A., Lotze, M.T., Muul, L.M., Chang, A.E., Avis, F.P., Leitman, S., Linehan, W.M., Robertson, C.N., Lee, R.E., & Rubin, J.T. (1987). A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone. N Engl J Med, 316(15), 889-897.Massachusetts Medical Society. doi: 10.1056/NEJM198704093161501.
Skibber, J.M., Lotze, M.T., Muul, L.M., Uppenkamp, I.K., Ross, W., & Rosenberg, S.A. (1987). Human lymphokine-activated killer cells: further isolation and characterization of the precursor and effector cell. Nat Immun Cell Growth Regul, 6(6), 291-305.
Skibber, J.M., Lotze, M.T., Seipp, C.A., Salcedo, R., & Rosenberg, S.A. (1987). Limb-sparing surgery for soft tissue sarcomas: wound related morbidity in patients undergoing wide local excision. Surgery, 102(3), 447-452.
Skibber, J.M., Lotze, M.T., Uppenkamp, I., Ross, W., & Rosenberg, S.A. (1987). Identification and expansion of human lymphokine-activated killer cells: implications for the immunotherapy of cancer. J Surg Res, 42(6), 613-621.Elsevier. doi: 10.1016/0022-4804(87)90004-7.
Skibber, J.M., Matter, G.J., Pizzo, P.A., & Lotze, M.T. (1987). Right lower quadrant pain in young patients with leukemia. Annals of Surgery, 206(6), 711-716. doi: 10.1097/00000658-198712000-00005.
Vetto, J.T., Papa, M.Z., Lotze, M.T., Chang, A.E., & Rosenberg, S.A. (1987). Reduction of toxicity of interleukin-2 and lymphokine-activated killer cells in humans by the administration of corticosteroids. J Clin Oncol, 5(3), 496-503.American Society of Clinical Oncology (ASCO). doi: 10.1200/JCO.1987.5.3.496.
Wiebke, E.A., Lotze, M.T., & Rosenberg, S.A. (1987). Tumor cell susceptibility to lysis: Marked increase in lysis by tumor-infiltrating lymphocytes following target stimulation with interferon-γ and tumor necrosis factor-α - Implications for immunotherapy. Surgical Forum, 38, 436-438.
Lotze, M.T. (1986). Surgical considerations in the diagnosis and management of AIDS. AIDS Res, 2(2), 141-148.Mary Ann Liebert. doi: 10.1089/aid.1.1986.2.141.
Lotze, M.T. (1986). High-Dose Recombinant Interleukin 2 in the Treatment of Patients With Disseminated Cancer. JAMA, 256(22), 3117.American Medical Association (AMA). doi: 10.1001/jama.1986.03380220083027.
Lotze, M.T., & Rosenberg, S.A. (1986). Results of clinical trials with the administration of interleukin 2 and adoptive immunotherapy with activated cells in patients with cancer. Immunobiology, 172(3-5), 420-437.Elsevier. doi: 10.1016/S0171-2985(86)80122-X.
Lotze, M.T., & Rosenberg, S.A. (1986). Protocol design for lymphokine testing in clinical studies of human cancer. Lymphokine Res, 5 Suppl 1(SUPPL. 1), S177-S181.
Lotze, M.T., Carrasquillo, J.A., Weinstein, J.N., Bryant, G.J., Perentesis, P., Reynolds, J.C., Matis, L.A., Eger, R.R., Keenan, A.M., & Hellström, I. (1986). Monoclonal antibody imaging of human melanoma. Radioimmunodetection by subcutaneous or systemic injection. Ann Surg, 204(3), 223-235.Wolters Kluwer. doi: 10.1097/00000658-198609000-00002.
Lotze, M.T., Chang, A.E., Seipp, C.A., Simpson, C., Vetto, J.T., & Rosenberg, S.A. (1986). High-dose recombinant interleukin 2 in the treatment of patients with disseminated cancer. Responses, treatment-related morbidity, and histologic findings. JAMA, 256(22), 3117-3124.American Medical Association (AMA). doi: 10.1001/jama.256.22.3117.
Lotze, M.T., Custer, M.C., & Rosenberg, S.A. (1986). Intraperitoneal administration of interleukin-2 in patients with cancer. Arch Surg, 121(12), 1373-1379.American Medical Association (AMA). doi: 10.1001/archsurg.1986.01400120019002.
Lotze, M.T., Matory, Y.L., Rayner, A.A., Ettinghausen, S.E., Vetto, J.T., Seipp, C.A., & Rosenberg, S.A. (1986). Clinical effects and toxicity of interleukin‐2 in patients with cancer. Cancer, 58(12), 2764-2772. doi: 10.1002/1097-0142(19861215)58:12<2764::AID-CNCR2820581235>3.0.CO;2-Z.
Perez, P., Titus, J.A., Lotze, M.T., Cuttitta, F., Longo, D.L., Groves, E.S., Rabin, H., Durda, P.J., & Segal, D.M. (1986). Specific lysis of human tumor cells by T cells coated with anti-T3 cross-linked to anti-tumor antibody. J Immunol, 137(7), 2069-2072.Oxford University Press (OUP). doi: 10.4049/jimmunol.137.7.2069.
Rosenberg, S.A., & Lotze, M.T. (1986). Cancer immunotherapy using interleukin-2 and interleukin-2-activated lymphocytes. Annu Rev Immunol, 4(1), 681-709.Annual Reviews. doi: 10.1146/annurev.iy.04.040186.003341.
Rosenberg, S.A., Lotze, M.T., Muul, L.M., Leitman, S., Chang, A.E., Vetto, J.T., Seipp, C.A., & Simpson, C. (1986). A new approach to the therapy of cancer based on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2. Surgery, 100(2), 262-272.
Skibber, J.M., Lotze, M.T., Garra, B., & Fauci, A. (1986). Successful management of hepatic abscesses by percutaneous catheter drainage in chronic granulomatous disease. Surgery, 99(5), 626-630.
Chang, A.E., Lotze, M.T., Ames, R.S., Roth, J.A., & Rosenberg, S.A. (1985). A large scale method of separating multiple lymphokines secreted by the murine EL-4 thymoma. J Immunopharmacol, 7(1), 17-31.Taylor & Francis. doi: 10.3109/08923978509026466.
Chang, A.E., Lotze, M.T., Ames, R.S., Roth, J.A., & Rosenberg, S.A. (1985). A large scale method of separating multiple lymphokines secreted by the murine EL-4 thymoma. Journal of Immunopharmacology, 7(1), 17-31.
Lotze, M.T., & Sugarbaker, P.H. (1985). Femoral artery based myocutaneous flap for hemipelvectomy closure: amputation after failed limb-sparing surgery and radiotherapy. Am J Surg, 150(5), 625-630.Elsevier. doi: 10.1016/0002-9610(85)90451-9.
Lotze, M.T., Frana, L.W., Sharrow, S.O., Robb, R.J., & Rosenberg, S.A. (1985). In vivo administration of purified human interleukin 2. I. Half-life and immunologic effects of the Jurkat cell line-derived interleukin 2. J Immunol, 134(1), 157-166.Oxford University Press (OUP). doi: 10.4049/jimmunol.134.1.157.
Lotze, M.T., Matory, Y.L., Ettinghausen, S.E., Rayner, A.A., Sharrow, S.O., Seipp, C.A., Custer, M.C., & Rosenberg, S.A. (1985). In vivo administration of purified human interleukin 2. II. Half life, immunologic effects, and expansion of peripheral lymphoid cells in vivo with recombinant IL 2. J Immunol, 135(4), 2865-2875.Oxford University Press (OUP). doi: 10.4049/jimmunol.135.4.2865.
Lotze, M.T., Rayner, A.A., & Grimm, E.A. (1985). Problems with the isolation of lymphoid clones with reactivity to human tumors. Behring Inst Mitt, (77), 105-114.
Rayner, A.A., Grimm, E.A., Lotze, M.T., Chu, E.W., & Rosenberg, S.A. (1985). Lymphokine‐activated killer (LAK) cells. Analysis of factors relevant to the immunotherapy of human cancer. Cancer, 55(6), 1327-1333. doi: 10.1002/1097-0142(19850315)55:6<1327::AID-CNCR2820550628>3.0.CO;2-O.
Rayner, A.A., Grimm, E.A., Lotze, M.T., Wilson, D.J., & Rosenberg, S.A. (1985). Lymphokine-activated killer (LAK) cell phenomenon. IV. Lysis by LAK cell clones of fresh human tumor cells from autologous and multiple allogeneic tumors. J Natl Cancer Inst, 75(1), 67-75.Oxford University Press (OUP). doi: 10.1093/jnci/75.1.67.
Rosenberg, S.A., Lotze, M.T., Muul, L.M., Leitman, S., Chang, A.E., Ettinghausen, S.E., Matory, Y.L., Skibber, J.M., Shiloni, E., & Vetto, J.T. (1985). Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer. N Engl J Med, 313(23), 1485-1492.Massachusetts Medical Society. doi: 10.1056/NEJM198512053132327.
Donohue, J.H., Lotze, M.T., Robb, R.J., Rosenstein, M., Braziel, R.M., Jaffe, E.S., & Rosenberg, S.A. (1984). In vivo administration of purified Jurkat-derived interleukin 2 in mice. Cancer Res, 44(4), 1380-1386.
Donohue, J.H., Rosenstein, M., Chang, A.E., Lotze, M.T., Robb, R.J., & Rosenberg, S.A. (1984). The systemic administration of purified interleukin 2 enhances the ability of sensitized murine lymphocytes to cure a disseminated syngeneic lymphoma. J Immunol, 132(4), 2123-2128.Oxford University Press (OUP). doi: 10.4049/jimmunol.132.4.2123.
Grimm, E.A., Vose, B.M., Chu, E.W., Wilson, D.J., Lotze, M.T., Rayner, A.A., & Rosenberg, S.A. (1984). The human mixed lymphocyte-tumor cell interaction test. I. Positive autologous lymphocyte proliferative responses can be stimulated by tumor cells as well as by cells from normal tissues. Cancer Immunol Immunother, 17(2), 83-89.Springer Nature. doi: 10.1007/BF00200041.
Longo, D.L., Steis, R.G., Lane, H.C., Lotze, M.T., Rosenberg, S.A., Preble, O., Masur, H., Rook, A.H., Fauci, A.S., & Jacob, J. (1984). Malignancies in the AIDS patient: natural history, treatment strategies, and preliminary results. Ann N Y Acad Sci, 437(DEC), 421-430.Wiley. doi: 10.1111/j.1749-6632.1984.tb37163.x.
Lotze, M.T., & Rosenberg, S.A. (1984). In vivo use of cytokines. Clinical and Applied Immunology Reviews, 5(8), 116-120.Elsevier. doi: 10.1016/s0197-1859(84)80031-x.
LOTZE, M.T., FRANA, L.W., SEIPP, C.A., SHARROW, S.O., & ROSENBERG, S.A. (1984). IMMUNOLOGICAL CHANGES IN PATIENTS WITH CANCER GIVEN INTERLEUKIN-2 (IL-2) IN A PHASE-I TRIAL. SURGICAL FORUM, 35, 407-408.
Lotze, M.T., Robb, R.J., Sharrow, S.O., Frana, L.W., & Rosenberg, S.A. (1984). Systemic administration of interleukin-2 in humans. J Biol Response Mod, 3(5), 475-482.
Ouriel, K., Lotze, M.T., & Hinshaw, J.R. (1984). Prognostic factors of carcinoma of the male breast. Surg Gynecol Obstet, 159(4), 373-376.
RAYNER, A.A., GRIMM, E.A., LOTZE, M.T., & ROSENBERG, S.A. (1984). DEMONSTRATION OF SHARED RECOGNITION AND LYSIS OF AUTOLOGOUS AND ALLOGENEIC FRESH HUMAN-TUMORS BY CLONED LYMPHOKINE-ACTIVATED KILLER CELLS. SURGICAL FORUM, 35, 415-417.
Harvey, J., Lotze, M., Arnett, F.C., Bias, W.B., Billingsley, L.M., Harvey, E., Hsu, S.H., Sutton, J.D., Zizic, T.M., & Stevens, M.B. (1983). Rheumatoid arthritis in a Chippewa band. II. Field study with clinical serologic and HLA-D correlations. J Rheumatol, 10(1), 28-32.
Lotze, M.T., Marquis, D.M., & Carey, A.S. (1983). Two new assays for the early detection of transplant rejection: IL-2 response and PHA-augmented NK activity. Transplantation Proceedings, 15(3), 1796-1799.
Rosenberg, S.A., Eberlein, T.J., Grimm, E.A., Lotze, M.T., Mazumder, A., & Rosenstein, M. (1982). Development of long-term cell lines and lymphoid clones reactive against murine and human tumors: a new approach to the adoptive immunotherapy of cancer. Surgery, 92(2), 328-336.
Bias, W.B., Hsu, S.H., Pollard, M.K., Harvey, J., Lotze, M.T., Arnett, F.C., & Stevens, M.B. (1981). HLA-DR characterization of a Chippewa Indian subpopulation with high prevalence of rheumatoid arthritis. Hum Immunol, 2(2), 155-163.Elsevier. doi: 10.1016/0198-8859(81)90062-8.
Harvey, J., Lotze, M., Stevens, M.B., Lambert, G., & Jacobson, D. (1981). Rheumatoid arthritis in a Chippewa Band. I. Pilot screening study of disease prevalence. Arthritis Rheum, 24(5), 717-721.Wiley. doi: 10.1002/art.1780240515.
Lotze, M.T., & Rosenberg, S.A. (1981). In vitro growth of cytotoxic human lymphocytes. III. The preparation of lectin-free T cell growth factor (TCGF) and an analysis of its activity. J Immunol, 126(6), 2215-2220.Oxford University Press (OUP). doi: 10.4049/jimmunol.126.6.2215.
Lotze, M.T., Duncan, M.A., Gerber, L.H., Woltering, E.A., & Rosenberg, S.A. (1981). Early versus delayed shoulder motion following axillary dissection: a randomized prospective study. Ann Surg, 193(3), 288-295.Wolters Kluwer. doi: 10.1097/00000658-198103000-00007.
Lotze, M.T., Grimm, E.A., Mazumder, A., Strausser, J.L., & Rosenberg, S.A. (1981). Lysis of fresh and cultured autologous tumor by human lymphocytes cultured in T-cell growth factor. Cancer Res, 41(11 Pt 1), 4420-4425.
Strausser, J.L., Mazumder, A., Grimm, E.A., Lotze, M.T., & Rosenberg, S.A. (1981). Lysis of human solid tumors by autologous cells sensitized in vitro to alloantigens. J Immunol, 127(1), 266-271.Oxford University Press (OUP). doi: 10.4049/jimmunol.127.1.266.
Lotze, M.T., Line, B.R., Mathisen, D.J., & Rosenberg, S.A. (1980). The in vivo distribution of autologous human and murine lymphoid cells grown in T cell growth factor (TCGF): implications for the adoptive immunotherapy of tumors. J Immunol, 125(4), 1487-1493.Oxford University Press (OUP). doi: 10.4049/jimmunol.125.4.1487.
Lotze, M.T., Strausser, J.L., & Rosenberg, S.A. (1980). In vitro growth of cytotoxic human lymphocytes. II. Use of T cell growth factor (TCGF) to clone human T cells. J Immunol, 124(6), 2972-2978.Oxford University Press (OUP). doi: 10.4049/jimmunol.124.6.2972.
LOTZE, M.T., STRAUSSER, J.L., LINE, B.R., & ROSENBERG, S.A. (1980). TUMOR LYSIS BY HUMAN LYMPHOCYTES-T IN LONG-TERM CULTURE AND THEIR DISTRIBUTION INVIVO - IMPLICATIONS FOR IMMUNOTHERAPY. SURGICAL FORUM, 31, 404-406.
Wang, Q., Miskov-Zivanov, N., Liu, B., Faeder, J.R., Lotze, M., & Clarke, E.M. (2016). Formal Modeling and Analysis of Pancreatic Cancer Microenvironment. In Lecture Notes in Computer Science, 9859, (pp. 289-305).Springer Nature. doi: 10.1007/978-3-319-45177-0_18.
Gong, H., Wang, Q., Zuliani, P., Faeder, J., Lotze, M., & Clarke, E. (2011). Symbolic model checking of signaling pathways in pancreatic cancer. In 3rd International Conference on Bioinformatics and Computational Biology 2011, BICoB 2011, (pp. 245-250).
Washburn, N.R., Sun, S., Bencherif, S.A., Farkas, A., & Lotze, M.T. (2008). Local regulation of inflammation in wound healing responses. In 8th World Biomaterials Congress 2008, 4, (p. 2162).
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