Bruce Pitt

  • Tyurina, Y.Y., Shrivastava, I., Tyurin, V.A., Mao, G., Dar, H.H., Watkins, S., Epperly, M., Bahar, I., Shvedova, A.A., Pitt, B., Wenzel, S.E., Mallampalli, R.K., Sadovsky, Y., Gabrilovich, D., Greenberger, J.S., Bayır, H., & Kagan, V.E. (2018). "Only a Life Lived for Others Is Worth Living": Redox Signaling by Oxygenated Phospholipids in Cell Fate Decisions. Antioxid Redox Signal, 29(13), 1333-1358.SAGE Publications. doi: 10.1089/ars.2017.7124.
  • Buland, J.R., Wasserloos, K.J., Tyurin, V.A., Tyurina, Y.Y., Amoscato, A.A., Mallampalli, R.K., Chen, B.B., Zhao, J., Zhao, Y., Ofori-Acquah, S., Kagan, V.E., & Pitt, B.R. (2016). Biosynthesis of oxidized lipid mediators via lipoprotein-associated phospholipase A2 hydrolysis of extracellular cardiolipin induces endothelial toxicity. Am J Physiol Lung Cell Mol Physiol, 311(2), L303-L316.American Physiological Society. doi: 10.1152/ajplung.00038.2016.
  • Stacy, S.L., Brink, L.L., Larkin, J.C., Sadovsky, Y., Goldstein, B.D., Pitt, B.R., & Talbott, E.O. (2015). Perinatal outcomes and unconventional natural gas operations in Southwest Pennsylvania. In Meliker, J. (Ed.). PLoS One, 10(6), e0126425.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0126425.
  • Andes, E. (2014). An examination of scenarios in dengue fever transmission with considerations in vector control, blood donation, and health communications in the United States. University of Pittsburgh.
  • Watson, K. (2014). Pharmaceuticals in the water: histological effects and intersex wildlife and sexual disruption. University of Pittsburgh.
  • Li, H.H., Li, J., Wasserloos, K.J., Wallace, C., Sullivan, M.G., Bauer, P.M., Stolz, D.B., Lee, J.S., Watkins, S.C., St Croix, C.M., Pitt, B.R., & Zhang, L.M. (2013). Caveolae-dependent and -independent uptake of albumin in cultured rodent pulmonary endothelial cells. In Zhao, Y.Y. (Ed.). PLoS One, 8(11), e81903.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0081903.
  • Cioffi, D.L., Wu, S., Chen, H., Alexeyev, M., St Croix, C.M., Pitt, B.R., Uhlig, S., & Stevens, T. (2012). Orai1 determines calcium selectivity of an endogenous TRPC heterotetramer channel. Circ Res, 110(11), 1435-1444.Wolters Kluwer. doi: 10.1161/CIRCRESAHA.112.269506.
  • Gorbunov, N.V., Atkins, J.L., Gurusamy, N., & Pitt, B.R. (2012). Iron-induced remodeling in cultured rat pulmonary artery endothelial cells. Biometals, 25(1), 203-217.Springer Nature. doi: 10.1007/s10534-011-9498-2.
  • Li, H.H., Li, Q., Liu, P., Liu, Y., Li, J., Wasserloos, K., Chao, W., You, M., Oury, T.D., Chhinder, S., Hackam, D.J., Billiar, T.R., Leikauf, G.D., Pitt, B.R., & Zhang, L.M. (2012). WNT1-inducible signaling pathway protein 1 contributes to ventilator-induced lung injury. Am J Respir Cell Mol Biol, 47(4), 528-535.Oxford University Press (OUP). doi: 10.1165/rcmb.2012-0127OC.
  • Sparvero, L.J., Amoscato, A.A., Dixon, C.E., Long, J.B., Kochanek, P.M., Pitt, B.R., Bayir, H., & Kagan, V.E. (2012). Mapping of phospholipids by MALDI imaging (MALDI-MSI): realities and expectations. Chem Phys Lipids, 165(5), 545-562.Elsevier. doi: 10.1016/j.chemphyslip.2012.06.001.
  • Thambiayya, K., Wasserloos, K., Kagan, V.E., Stoyanovsky, D., & Pitt, B.R. (2012). A critical role for increased labile zinc in reducing sensitivity of cultured sheep pulmonary artery endothelial cells to LPS-induced apoptosis. Am J Physiol Lung Cell Mol Physiol, 302(12), L1287-L1295.American Physiological Society. doi: 10.1152/ajplung.00385.2011.
  • Atkinson, J., Kapralov, A.A., Yanamala, N., Tyurina, Y.Y., Amoscato, A.A., Pearce, L., Peterson, J., Huang, Z., Jiang, J., Samhan-Arias, A.K., Maeda, A., Feng, W., Wasserloos, K., Belikova, N.A., Tyurin, V.A., Wang, H., Fletcher, J., Wang, Y., Vlasova, I.I., Klein-Seetharaman, J., Stoyanovsky, D.A., Bayîr, H., Pitt, B.R., Epperly, M.W., Greenberger, J.S., & Kagan, V.E. (2011). A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced death. Nature communications, 2, 497.
  • Bernal, P.J., Bauer, E.M., Cao, R., Maniar, S., Mosher, M., Chen, J., Wang, Q.J., Glorioso, J.C., Pitt, B.R., Watkins, S.C., & St Croix, C.M. (2011). A role for zinc in regulating hypoxia-induced contractile events in pulmonary endothelium. Am J Physiol Lung Cell Mol Physiol, 300(6), L874-L886.American Physiological Society. doi: 10.1152/ajplung.00328.2010.
  • Cambal, L.K., Swanson, M.R., Yuan, Q., Weitz, A.C., Li, H.H., Pitt, B.R., Pearce, L.L., & Peterson, J. (2011). Acute, sublethal cyanide poisoning in mice is ameliorated by nitrite alone: complications arising from concomitant administration of nitrite and thiosulfate as an antidotal combination. Chem Res Toxicol, 24(7), 1104-1112.American Chemical Society (ACS). doi: 10.1021/tx2001042.
  • Li, H.H., Xu, J., Wasserloos, K.J., Li, J., Tyurina, Y.Y., Kagan, V.E., Wang, X., Chen, A.F., Liu, Z.Q., Stoyanovsky, D., Pitt, B.R., & Zhang, L.M. (2011). Cytoprotective effects of albumin, nitrosated or reduced, in cultured rat pulmonary vascular cells. Am J Physiol Lung Cell Mol Physiol, 300(4), L526-L533.American Physiological Society. doi: 10.1152/ajplung.00282.2010.
  • Thambiayya, K., Wasserloos, K.J., Huang, Z., Kagan, V.E., St Croix, C.M., & Pitt, B.R. (2011). LPS-induced decrease in intracellular labile zinc, [Zn]i, contributes to apoptosis in cultured sheep pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol, 300(4), L624-L632.American Physiological Society. doi: 10.1152/ajplung.00376.2010.
  • Tyurina, Y.Y., Tyurin, V.A., Kapralova, V.I., Wasserloos, K., Mosher, M., Epperly, M.W., Greenberger, J.S., Pitt, B.R., & Kagan, V.E. (2011). Oxidative lipidomics of γ-radiation-induced lung injury: mass spectrometric characterization of cardiolipin and phosphatidylserine peroxidation. Radiat Res, 175(5), 610-621.Radiation Research Society. doi: 10.1667/RR2297.1.
  • Gamble, C., Talbott, E., Youk, A., Holguin, F., Pitt, B., Silveira, L., Bleecker, E., Busse, W., Calhoun, W., Castro, M., Chung, K.F., Erzurum, S., Israel, E., & Wenzel, S. (2010). Racial differences in biologic predictors of severe asthma: Data from the Severe Asthma Research Program. J Allergy Clin Immunol, 126(6), 1149-56.e1.Elsevier. doi: 10.1016/j.jaci.2010.08.049.
  • John, E., Laskow, T.C., Buchser, W.J., Pitt, B.R., Basse, P.H., Butterfield, L.H., Kalinski, P., & Lotze, M.T. (2010). Zinc in innate and adaptive tumor immunity. J Transl Med, 8(1), 118.Springer Nature. doi: 10.1186/1479-5876-8-118.
  • Li, H., Cao, R., Wasserloos, K.J., Bernal, P., Liu, Z.Q., Pitt, B.R., & St Croix, C.M. (2010). Nitric oxide and zinc homeostasis in pulmonary endothelium. Ann N Y Acad Sci, 1203(1), 73-78.Wiley. doi: 10.1111/j.1749-6632.2010.05558.x.
  • Li, H., Su, X., Yan, X., Wasserloos, K., Chao, W., Kaynar, A.M., Liu, Z.Q., Leikauf, G.D., Pitt, B.R., & Zhang, L.M. (2010). Toll-like receptor 4-myeloid differentiation factor 88 signaling contributes to ventilator-induced lung injury in mice. Anesthesiology, 113(3), 619-629.Wolters Kluwer. doi: 10.1097/ALN.0b013e3181e89ab2.
  • Phillippi, J.A., Eskay, M.A., Kubala, A.A., Pitt, B.R., & Gleason, T.G. (2010). Altered oxidative stress responses and increased type I collagen expression in bicuspid aortic valve patients. Ann Thorac Surg, 90(6), 1893-1898.Elsevier. doi: 10.1016/j.athoracsur.2010.07.069.
  • Polk, A.A., Maul, T.M., McKeel, D.T., Snyder, T.A., Lehocky, C.A., Pitt, B., Stolz, D.B., Federspiel, W.J., & Wagner, W.R. (2010). A biohybrid artificial lung prototype with active mixing of endothelialized microporous hollow fibers. Biotechnol Bioeng, 106(3), 490-500.Wiley. doi: 10.1002/bit.22675.
  • Sparvero, L.J., Amoscato, A.A., Kochanek, P.M., Pitt, B.R., Kagan, V.E., & Bayir, H. (2010). Mass-spectrometry based oxidative lipidomics and lipid imaging: applications in traumatic brain injury. J Neurochem, 115(6), 1322-1336.Wiley. doi: 10.1111/j.1471-4159.2010.07055.x.
  • Szczepaniak, W.S., Pitt, B.R., & McVerry, B.J. (2010). S1P2 receptor-dependent Rho-kinase activation mediates vasoconstriction in the murine pulmonary circulation induced by sphingosine 1-phosphate. Am J Physiol Lung Cell Mol Physiol, 299(1), L137-L145.American Physiological Society. doi: 10.1152/ajplung.00233.2009.
  • Tyurina, Y.Y., Tyurin, V.A., Kaynar, A.M., Kapralova, V.I., Wasserloos, K., Li, J., Mosher, M., Wright, L., Wipf, P., Watkins, S., Pitt, B.R., & Kagan, V.E. (2010). Oxidative lipidomics of hyperoxic acute lung injury: mass spectrometric characterization of cardiolipin and phosphatidylserine peroxidation. Am J Physiol Lung Cell Mol Physiol, 299(1), L73-L85.American Physiological Society. doi: 10.1152/ajplung.00035.2010.
  • Garner, A.L., St Croix, C.M., Pitt, B.R., Leikauf, G.D., Ando, S., & Koide, K. (2009). Specific fluorogenic probes for ozone in biological and atmospheric samples. Nat Chem, 1(4), 316-321.Springer Nature. doi: 10.1038/nchem.240.
  • Kagan, V.E., Bayir, H.A., Belikova, N.A., Kapralov, O., Tyurina, Y.Y., Tyurin, V.A., Jiang, J., Stoyanovsky, D.A., Wipf, P., Kochanek, P.M., Greenberger, J.S., Pitt, B., Shvedova, A.A., & Borisenko, G. (2009). Cytochrome c/cardiolipin relations in mitochondria: a kiss of death. Free Radic Biol Med, 46(11), 1439-1453.Elsevier. doi: 10.1016/j.freeradbiomed.2009.03.004.
  • Kagan, V.E., Wipf, P., Stoyanovsky, D., Greenberger, J.S., Borisenko, G., Belikova, N.A., Yanamala, N., Samhan Arias, A.K., Tungekar, M.A., Jiang, J., Tyurina, Y.Y., Ji, J., Klein-Seetharaman, J., Pitt, B.R., Shvedova, A.A., & Bayir, H. (2009). Mitochondrial targeting of electron scavenging antioxidants: Regulation of selective oxidation vs random chain reactions. Adv Drug Deliv Rev, 61(14), 1375-1385.Elsevier. doi: 10.1016/j.addr.2009.06.008.
  • Li, J., Wilson, A., Gao, X., Kuruba, R., Liu, Y., Poloyac, S., Pitt, B., Xie, W., & Li, S. (2009). Coordinated regulation of dimethylarginine dimethylaminohydrolase-1 and cationic amino acid transporter-1 by farnesoid X receptor in mouse liver and kidney and its implication in the control of blood levels of asymmetric dimethylarginine. J Pharmacol Exp Ther, 331(1), 234-243.Elsevier. doi: 10.1124/jpet.109.153510.
  • Nemec, A.A., Leikauf, G.D., Pitt, B.R., Wasserloos, K.J., & Barchowsky, A. (2009). Nickel mobilizes intracellular zinc to induce metallothionein in human airway epithelial cells. Am J Respir Cell Mol Biol, 41(1), 69-75.Oxford University Press (OUP). doi: 10.1165/rcmb.2008-0409OC.
  • Tyurin, V.A., Tyurina, Y.Y., Jung, M.Y., Tungekar, M.A., Wasserloos, K.J., Bayir, H., Greenberger, J.S., Kochanek, P.M., Shvedova, A.A., Pitt, B., & Kagan, V.E. (2009). Mass-spectrometric analysis of hydroperoxy- and hydroxy-derivatives of cardiolipin and phosphatidylserine in cells and tissues induced by pro-apoptotic and pro-inflammatory stimuli. J Chromatogr B Analyt Technol Biomed Life Sci, 877(26), 2863-2872.Elsevier. doi: 10.1016/j.jchromb.2009.03.007.
  • Bernal, P.J., Leelavanichkul, K., Bauer, E., Cao, R., Wilson, A., Wasserloos, K.J., Watkins, S.C., Pitt, B.R., & St Croix, C.M. (2008). Nitric-oxide-mediated zinc release contributes to hypoxic regulation of pulmonary vascular tone. Circ Res, 102(12), 1575-1583.Wolters Kluwer. doi: 10.1161/CIRCRESAHA.108.171264.
  • Fattman, C.L., Gambelli, F., Hoyle, G., Pitt, B.R., & Ortiz, L.A. (2008). Epithelial expression of TIMP-1 does not alter sensitivity to bleomycin-induced lung injury in C57BL/6 mice. Am J Physiol Lung Cell Mol Physiol, 294(3), L572-L581.American Physiological Society. doi: 10.1152/ajplung.00291.2007.
  • Kaynar, A.M., Houghton, A.M., Lum, E.H., Pitt, B.R., & Shapiro, S.D. (2008). Neutrophil elastase is needed for neutrophil emigration into lungs in ventilator-induced lung injury. Am J Respir Cell Mol Biol, 39(1), 53-60.Oxford University Press (OUP). doi: 10.1165/rcmb.2007-0315OC.
  • Kleinschmidt, A.M., Nassiri, M., Stitt, M.S., Wasserloos, K., Watkins, S.C., Pitt, B.R., & Jahroudi, N. (2008). Sequences in intron 51 of the von Willebrand factor gene target promoter activation to a subset of lung endothelial cells in transgenic mice. J Biol Chem, 283(5), 2741-2750.Elsevier. doi: 10.1074/jbc.M705466200.
  • Li, J., Wilson, A., Kuruba, R., Zhang, Q., Gao, X., He, F., Zhang, L.M., Pitt, B.R., Xie, W., & Li, S. (2008). FXR-mediated regulation of eNOS expression in vascular endothelial cells. Cardiovasc Res, 77(1), 169-177.Oxford University Press (OUP). doi: 10.1093/cvr/cvm016.
  • Zhang, Q., He, F., Kuruba, R., Gao, X., Wilson, A., Li, J., Billiar, T.R., Pitt, B.R., Xie, W., & Li, S. (2008). FXR-mediated regulation of angiotensin type 2 receptor expression in vascular smooth muscle cells. Cardiovasc Res, 77(3), 560-569.Oxford University Press (OUP). doi: 10.1093/cvr/cvm068.
  • Tyurina, Y.Y., Basova, L.V., Konduru, N.V., Tyurin, V.A., Potapovich, A.I., Cai, P., Bayir, H., Stoyanovsky, D., Pitt, B.R., Shvedova, A.A., Fadeel, B., & Kagan, V.E. (2007). Nitrosative stress inhibits the aminophospholipid translocase resulting in phosphatidylserine externalization and macrophage engulfment: implications for the resolution of inflammation. J Biol Chem, 282(11), 8498-8509.Elsevier. doi: 10.1074/jbc.M606950200.
  • He, F., Li, J., Mu, Y., Kuruba, R., Ma, Z., Wilson, A., Alber, S., Jiang, Y., Stevens, T., Watkins, S., Pitt, B., Xie, W., & Li, S. (2006). Downregulation of endothelin-1 by farnesoid X receptor in vascular endothelial cells. Circ Res, 98(2), 192-199.Wolters Kluwer. doi: 10.1161/01.RES.0000200400.55539.85.
  • Matthay, M.A., Christman, J.W., Pitt, B.R., Schwiebert, L.M., Stevens, T., & Ware, L.B. (2006). Perspectives, translational research, and letters to the editor. Am J Physiol Lung Cell Mol Physiol, 290(4), L621.American Physiological Society. doi: 10.1152/ajplung.00003.2006.
  • Stitt, M.S., Wasserloos, K.J., Tang, X., Liu, X., Pitt, B.R., & St Croix, C.M. (2006). Nitric oxide-induced nuclear translocation of the metal responsive transcription factor, MTF-1 is mediated by zinc release from metallothionein. Vascul Pharmacol, 44(3), 149-155.Elsevier. doi: 10.1016/j.vph.2005.10.004.
  • Zhang, L.M., St Croix, C., Cao, R., Wasserloos, K., Watkins, S.C., Stevens, T., Li, S., Tyurin, V., Kagan, V.E., & Pitt, B.R. (2006). Cell-surface protein disulfide isomerase is required for transnitrosation of metallothionein by S-nitroso-albumin in intact rat pulmonary vascular endothelial cells. Exp Biol Med (Maywood), 231(9), 1507-1515.Frontiers. doi: 10.1177/153537020623100909.
  • Gandley, R.E., Tyurin, V.A., Huang, W., Arroyo, A., Daftary, A., Harger, G., Jiang, J., Pitt, B., Taylor, R.N., Hubel, C.A., & Kagan, V.E. (2005). S-nitrosoalbumin-mediated relaxation is enhanced by ascorbate and copper: effects in pregnancy and preeclampsia plasma. Hypertension, 45(1), 21-27.Wolters Kluwer. doi: 10.1161/01.HYP.0000150158.42620.3e.
  • Ma, Z., Li, J., He, F., Wilson, A., Pitt, B., & Li, S. (2005). Cationic lipids enhance siRNA-mediated interferon response in mice. Biochem Biophys Res Commun, 330(3), 755-759.Elsevier. doi: 10.1016/j.bbrc.2005.03.041.
  • St Croix, C.M., Leelavaninchkul, K., Watkins, S.C., Kagan, V.E., & Pitt, B.R. (2005). Nitric oxide and zinc homeostasis in acute lung injury. Proc Am Thorac Soc, 2(3), 236-242.Oxford University Press (OUP). doi: 10.1513/pats.200501-007AC.
  • St Croix, C.M., Pitt, B.R., & Watkins, S.C. (2005). The use of contemporary fluorescent imaging technologies in biomedical research. Medicine and Science, 10(1), 16-29.
  • St Croix, C.M., Stitt, M.S., Watkins, S.C., & Pitt, B.R. (2005). Fluorescence resonance energy transfer-based assays for the real-time detection of nitric oxide signaling. Methods Enzymol, 396, 317-326.Elsevier. doi: 10.1016/S0076-6879(05)96026-6.
  • Stoyanovsky, D.A., Tyurina, Y.Y., Tyurin, V.A., Anand, D., Mandavia, D.N., Gius, D., Ivanova, J., Pitt, B., Billiar, T.R., & Kagan, V.E. (2005). Thioredoxin and lipoic acid catalyze the denitrosation of low molecular weight and protein S-nitrosothiols. J Am Chem Soc, 127(45), 15815-15823.American Chemical Society (ACS). doi: 10.1021/ja0529135.
  • Wilson, A., He, F., Li, J., Ma, Z., Pitt, B., & Li, S. (2005). Targeted Delivery of Therapeutic Oligonucleotides to Pulmonary Circulation. In NON-VIRAL VECTORS FOR GENE THERAPY, SECOND EDITION: PART 2. 54, (pp. 21-41).Elsevier. doi: 10.1016/S0065-2660(05)54002-1.
  • Wilson, A., He, F., Li, J., Ma, Z., Pitt, B., & Li, S. (2005). Targeted delivery of therapeutic oligonucleotides to pulmonary circulation. Adv Genet, 54, 21-41. doi: 10.1016/S0065-2660(05)54002-1.
  • Wilson, A., Zhou, W., Champion, H.C., Alber, S., Tang, Z.L., Kennel, S., Watkins, S., Huang, L., Pitt, B., & Li, S. (2005). Targeted delivery of oligodeoxynucleotides to mouse lung endothelial cells in vitro and in vivo. Mol Ther, 12(3), 510-518.Elsevier. doi: 10.1016/j.ymthe.2005.04.005.
  • Li, J., Ma, Z., Tang, Z.L., Stevens, T., Pitt, B., & Li, S. (2004). CpG DNA-mediated immune response in pulmonary endothelial cells. Am J Physiol Lung Cell Mol Physiol, 287(3), L552-L558.American Physiological Society. doi: 10.1152/ajplung.00436.2003.
  • Ma, Z., Li, J., Yang, L., Mu, Y., Xie, W., Pitt, B., & Li, S. (2004). Inhibition of LPS- and CpG DNA-induced TNF-alpha response by oxidized phospholipids. Am J Physiol Lung Cell Mol Physiol, 286(4), L808-L816.American Physiological Society. doi: 10.1152/ajplung.00220.2003.
  • Pitt, B.R., & Ortiz, L.A. (2004). Stem cells in lung biology. Am J Physiol Lung Cell Mol Physiol, 286(4), L621-L623.American Physiological Society. doi: 10.1152/ajplung.00392.2003.
  • St Croix, C.M., Stitt, M.S., Leelavanichkul, K., Wasserloos, K.J., Pitt, B.R., & Watkins, S.C. (2004). Nitric oxide-induced modification of protein thiolate clusters as determined by spectral fluorescence resonance energy transfer in live endothelial cells. Free Radic Biol Med, 37(6), 785-792.Elsevier. doi: 10.1016/j.freeradbiomed.2004.06.004.
  • Tyurina, Y.Y., Tyurin, V.A., Zhao, Q., Djukic, M., Quinn, P.J., Pitt, B.R., & Kagan, V.E. (2004). Oxidation of phosphatidylserine: a mechanism for plasma membrane phospholipid scrambling during apoptosis?. Biochem Biophys Res Commun, 324(3), 1059-1064.Elsevier. doi: 10.1016/j.bbrc.2004.09.102.
  • Lawler, C., Suk, W.A., Pitt, B.R., Croix, C.M.S., & Watkins, S.C. (2003). Multimodal optical imaging. Am J Physiol Lung Cell Mol Physiol, 285(2), L269-L280.American Physiological Society. doi: 10.1152/ajplung.00424.2002.
  • Zhang, J., Wilson, A., Alber, S., Ma, Z., Tang, Z.L., Satoh, E., Mazda, O., Watkins, S., Huang, L., Pitt, B., & Li, S. (2003). Prolonged gene expression in mouse lung endothelial cells following transfection with Epstein-Barr virus-based episomal plasmid. Gene Ther, 10(9), 822-826.Springer Nature. doi: 10.1038/sj.gt.3301958.
  • Fabisiak, J.P., Borisenko, G.G., Liu, S.X., Tyurin, V.A., Pitt, B.R., & Kagan, V.E. (2002). Redox sensor function of metallothioneins. Methods Enzymol, 353, 268-281.Elsevier. doi: 10.1016/s0076-6879(02)53055-x.
  • Jiang, J., St Croix, C.M., Sussman, N., Zhao, Q., Pitt, B.R., & Kagan, V.E. (2002). Contribution of glutathione and metallothioneins to protection against copper toxicity and redox cycling: quantitative analysis using MT+/+ and MT-/- mouse lung fibroblast cells. Chem Res Toxicol, 15(8), 1080-1087.American Chemical Society (ACS). doi: 10.1021/tx020022u.
  • Ma, Z., Mi, Z., Wilson, A., Alber, S., Robbins, P.D., Watkins, S., Pitt, B., & Li, S. (2002). Redirecting adenovirus to pulmonary endothelium by cationic liposomes. Gene Ther, 9(3), 176-182.Springer Nature. doi: 10.1038/sj.gt.3301636.
  • Ma, Z., Zhang, J., Alber, S., Dileo, J., Negishi, Y., Stolz, D., Watkins, S., Huang, L., Pitt, B., & Li, S. (2002). Lipid-mediated delivery of oligonucleotide to pulmonary endothelium. Am J Respir Cell Mol Biol, 27(2), 151-159.Oxford University Press (OUP). doi: 10.1165/ajrcmb.27.2.4653.
  • Pearce, L.L., Kanai, A.J., Birder, L.A., Pitt, B.R., & Peterson, J. (2002). The catabolic fate of nitric oxide: the nitric oxide oxidase and peroxynitrite reductase activities of cytochrome oxidase. J Biol Chem, 277(16), 13556-13562.Elsevier. doi: 10.1074/jbc.M109838200.
  • Pitt, B.R., & St Croix, C.M. (2002). Complex regulation of iNOS in lung. Am J Respir Cell Mol Biol, 26(1), 6-9.Oxford University Press (OUP). doi: 10.1165/ajrcmb.26.1.f224.
  • St Croix, C.M., Wasserloos, K.J., Dineley, K.E., Reynolds, I.J., Levitan, E.S., & Pitt, B.R. (2002). Nitric oxide-induced changes in intracellular zinc homeostasis are mediated by metallothionein/thionein. Am J Physiol Lung Cell Mol Physiol, 282(2), L185-L192.American Physiological Society. doi: 10.1152/ajplung.00267.2001.
  • Tang, Z.L., Wasserloos, K.J., Liu, X., Stitt, M.S., Reynolds, I.J., Pitt, B.R., & St Croix, C.M. (2002). Nitric oxide decreases the sensitivity of pulmonary endothelial cells to LPS-induced apoptosis in a zinc-dependent fashion. Mol Cell Biochem, 234-235(1-2), 211-217.Springer Nature. doi: 10.1023/a:1015930927407.
  • Wilson, A., Pitt, B., & Li, S. (2002). Complex roles of CpG in liposomal delivery of DNA and oligonucleotides. Biosci Rep, 22(2), 309-322.Portland Press. doi: 10.1023/a:1020146924504.
  • Zhou, W., Yuan, X., Wilson, A., Yang, L., Mokotoff, M., Pitt, B., & Li, S. (2002). Efficient intracellular delivery of oligonucleotides formulated in folate receptor-targeted lipid vesicles. Bioconjug Chem, 13(6), 1220-1225.American Chemical Society (ACS). doi: 10.1021/bc025569z.
  • Finder, J.D., Petrus, J.L., Hamilton, A., Villavicencio, R.T., Pitt, B.R., & Sebti, S.M. (2001). Signal transduction pathways of IL-1beta-mediated iNOS in pulmonary vascular smooth muscle cells. Am J Physiol Lung Cell Mol Physiol, 281(4), L816-L823.American Physiological Society. doi: 10.1152/ajplung.2001.281.4.L816.
  • Hauser, G.J., Wasserloos, K., Dayao, E.K., & Pitt, B.R. (2001). Effect of sodium arsenite on iNOS expression and vascular hyporeactivity associated with cecal ligation and puncture in the rat. Shock, 15(1), 73-76.Wolters Kluwer. doi: 10.1097/00024382-200115010-00012.
  • Liu, S., Kawai, K., Tyurin, V.A., Tyurina, Y.Y., Borisenko, G.G., Fabisiak, J.P., Quinn, P.J., Pitt, B.R., & Kagan, V.E. (2001). Nitric oxide-dependent pro-oxidant and pro-apoptotic effect of metallothioneins in HL-60 cells challenged with cupric nitrilotriacetate. Biochem J, 354(Pt 2), 397-406.Portland Press. doi: 10.1042/0264-6021:3540397.
  • Pearce, L.L., Epperly, M.W., Greenberger, J.S., Pitt, B.R., & Peterson, J. (2001). Identification of respiratory complexes I and III as mitochondrial sites of damage following exposure to ionizing radiation and nitric oxide. Nitric Oxide, 5(2), 128-136.Elsevier. doi: 10.1006/niox.2001.0338.
  • Pitt, B.R. (2001). CFTR trafficking and signaling in respiratory epithelium. Am J Physiol Lung Cell Mol Physiol, 281(1), L13-L15.American Physiological Society. doi: 10.1152/ajplung.2001.281.1.L13.
  • Tang, Z.L., Wasserloos, K., St Croix, C.M., & Pitt, B.R. (2001). Role of zinc in pulmonary endothelial cell response to oxidative stress. Am J Physiol Lung Cell Mol Physiol, 281(1), L243-L249.American Physiological Society. doi: 10.1152/ajplung.2001.281.1.L243.
  • Boota, A., Johnson, B., Lee, K.L., Blaskovich, M.A., Liu, S.X., Kagan, V.E., Hamilton, A., Pitt, B., Sebti, S.M., & Davies, P. (2000). Prenyltransferase inhibitors block superoxide production by pulmonary vascular smooth muscle. Am J Physiol Lung Cell Mol Physiol, 278(2), L329-L334.American Physiological Society. doi: 10.1152/ajplung.2000.278.2.L329.
  • Erukhimov, J.A., Tang, Z.L., Johnson, B.A., Donahoe, M.P., Razzack, J.A., Gibson, K.F., Lee, W.M., Wasserloos, K.J., Watkins, S.A., & Pitt, B.R. (2000). Actin-containing sera from patients with adult respiratory distress syndrome are toxic to sheep pulmonary endothelial cells. Am J Respir Crit Care Med, 162(1), 288-294.Oxford University Press (OUP). doi: 10.1164/ajrccm.162.1.9806088.
  • Johnson, B.A., Pitt, B.R., & Davies, P. (2000). Pulmonary arterial smooth muscle cells modulate cytokine- and LPS-induced cytotoxicity in endothelial cells. Am J Physiol Lung Cell Mol Physiol, 278(3), L460-L468.American Physiological Society. doi: 10.1152/ajplung.2000.278.3.L460.
  • Kawai, K., Liu, S.X., Tyurin, V.A., Tyurina, Y.Y., Borisenko, G.G., Jiang, J.F., St Croix, C.M., Fabisiak, J.P., Pitt, B.R., & Kagan, V.E. (2000). Antioxidant and antiapoptotic function of metallothioneins in HL-60 cells challenged with copper nitrilotriacetate. Chem Res Toxicol, 13(12), 1275-1286.American Chemical Society (ACS). doi: 10.1021/tx000119l.
  • Li, S., Tan, Y., Viroonchatapan, E., Pitt, B.R., & Huang, L. (2000). Targeted gene delivery to pulmonary endothelium by anti-PECAM antibody. Am J Physiol Lung Cell Mol Physiol, 278(3), L504-L511.American Physiological Society. doi: 10.1152/ajplung.2000.278.3.L504.
  • Liu, S.X., Fabisiak, J.P., Tyurin, V.A., Borisenko, G.G., Pitt, B.R., Lazo, J.S., & Kagan, V.E. (2000). Reconstitution of apo-superoxide dismutase by nitric oxide-induced copper transfer from metallothioneins. Chem Res Toxicol, 13(9), 922-931.American Chemical Society (ACS). doi: 10.1021/tx0000623.
  • Merker, M.P., Pitt, B.R., Choi, A.M., Hassoun, P.M., Dawson, C.A., & Fisher, A.B. (2000). Lung redox homeostasis: emerging concepts. Am J Physiol Lung Cell Mol Physiol, 279(3), L413-L417.American Physiological Society. doi: 10.1152/ajplung.2000.279.3.L413.
  • Pearce, L.L., Gandley, R.E., Han, W., Wasserloos, K., Stitt, M., Kanai, A.J., McLaughlin, M.K., Pitt, B.R., & Levitan, E.S. (2000). Role of metallothionein in nitric oxide signaling as revealed by a green fluorescent fusion protein. Proc Natl Acad Sci U S A, 97(1), 477-482.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.97.1.477.
  • Pearce, L.L., Wasserloos, K., St Croix, C.M., Gandley, R., Levitan, E.S., & Pitt, B.R. (2000). Metallothionein, nitric oxide and zinc homeostasis in vascular endothelial cells. J Nutr, 130(5S Suppl), 1467S-1470S.Elsevier. doi: 10.1093/jn/130.5.1467S.
  • Schwarz, M.A., Zhang, F., Lane, J.E., Schachtner, S., Jin, Y., Deutsch, G., Starnes, V., & Pitt, B.R. (2000). Angiogenesis and morphogenesis of murine fetal distal lung in an allograft model. Am J Physiol Lung Cell Mol Physiol, 278(5), L1000-L1007.American Physiological Society. doi: 10.1152/ajplung.2000.278.5.L1000.
  • Villavicencio, R.T., Liu, S., Kibbe, M.R., Williams, D.L., Ganster, R.W., Dyer, K.F., Tweardy, D.J., Billiar, T.R., & Pitt, B.R. (2000). Induced nitric oxide inhibits IL-6-induced stat3 activation and type II acute phase mRNA expression. Shock, 13(6), 441-445.Wolters Kluwer. doi: 10.1097/00024382-200006000-00004.
  • Davidge, S.T., Pitt, B.R., McLaughlin, M.K., Roberts, J.M., & Johnson, B.A. (1999). Biphasic stimulation of prostacyclin by endogenous nitric oxide (NO) in endothelial cells transfected with inducible NO synthase. Gen Pharmacol, 33(5), 383-387.Elsevier. doi: 10.1016/s0306-3623(99)00033-6.
  • Fabisiak, J.P., Pearce, L.L., Borisenko, G.G., Tyhurina, Y.Y., Tyurin, V.A., Razzack, J., Lazo, J.S., Pitt, B.R., & Kagan, V.E. (1999). Bifunctional anti/prooxidant potential of metallothionenin: redox signaling of copper binding and release. Antioxid Redox Signal, 1(3), 349-364.SAGE Publications. doi: 10.1089/ars.1999.1.3-349.
  • Fabisiak, J.P., Tyurin, V.A., Tyurina, Y.Y., Borisenko, G.G., Korotaeva, A., Pitt, B.R., Lazo, J.S., & Kagan, V.E. (1999). Redox regulation of copper-metallothionein. Arch Biochem Biophys, 363(1), 171-181.Elsevier. doi: 10.1006/abbi.1998.1077.
  • Li, S., Wu, S.P., Whitmore, M., Loeffert, E.J., Wang, L., Watkins, S.C., Pitt, B.R., & Huang, L. (1999). Effect of immune response on gene transfer to the lung via systemic administration of cationic lipidic vectors. Am J Physiol, 276(5), L796-L804.American Physiological Society. doi: 10.1152/ajplung.1999.276.5.L796.
  • Pearce, L.L., Pitt, B.R., & Peterson, J. (1999). The peroxynitrite reductase activity of cytochrome c oxidase involves a two-electron redox reaction at the heme a(3)-Cu(B) site. J Biol Chem, 274(50), 35763-35767.Elsevier. doi: 10.1074/jbc.274.50.35763.
  • Tan, Y., Li, S., Pitt, B.R., & Huang, L. (1999). The inhibitory role of CpG immunostimulatory motifs in cationic lipid vector-mediated transgene expression in vivo. Hum Gene Ther, 10(13), 2153-2161.SAGE Publications. doi: 10.1089/10430349950017149.
  • Ceneviva, G.D., Tzeng, E., Hoyt, D.G., Yee, E., Gallagher, A., Engelhardt, J.F., Kim, Y.M., Billiar, T.R., Watkins, S.A., & Pitt, B.R. (1998). Nitric oxide inhibits lipopolysaccharide-induced apoptosis in pulmonary artery endothelial cells. Am J Physiol, 275(4), L717-L728.American Physiological Society. doi: 10.1152/ajplung.1998.275.4.L717.
  • Lazo, J.S., Kuo, S.M., Woo, E.S., & Pitt, B.R. (1998). The protein thiol metallothionein as an antioxidant and protectant against antineoplastic drugs. Chem Biol Interact, 111-112, 255-262.Elsevier. doi: 10.1016/s0009-2797(97)00165-8.
  • Stark, W.W., Blaskovich, M.A., Johnson, B.A., Qian, Y., Vasudevan, A., Pitt, B., Hamilton, A.D., Sebti, S.M., & Davies, P. (1998). Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells. Am J Physiol, 275(1), L55-L63.American Physiological Society. doi: 10.1152/ajplung.1998.275.1.L55.
  • Hoyt, D.G., Rizzo, M., Gerritsen, M.E., Pitt, B.R., & Lazo, J.S. (1997). Integrin activation protects pulmonary endothelial cells from the genotoxic effects of bleomycin. Am J Physiol, 273(3 Pt 1), L612-L617.American Physiological Society. doi: 10.1152/ajplung.1997.273.3.L612.
  • Kondo, Y., Rusnak, J.M., Hoyt, D.G., Settineri, C.E., Pitt, B.R., & Lazo, J.S. (1997). Enhanced apoptosis in metallothionein null cells. Mol Pharmacol, 52(2), 195-201.Elsevier. doi: 10.1124/mol.52.2.195.
  • Pitt, B.R., Schwarz, M., Woo, E.S., Yee, E., Wasserloos, K., Tran, S., Weng, W., Mannix, R.J., Watkins, S.A., Tyurina, Y.Y., Tyurin, V.A., Kagan, V.E., & Lazo, J.S. (1997). Overexpression of metallothionein decreases sensitivity of pulmonary endothelial cells to oxidant injury. Am J Physiol, 273(4), L856-L865.American Physiological Society. doi: 10.1152/ajplung.1997.273.4.L856.
  • Tzeng, E., Kim, Y.M., Pitt, B.R., Lizonova, A., Kovesdi, I., & Billiar, T.R. (1997). Adenoviral transfer of the inducible nitric oxide synthase gene blocks endothelial cell apoptosis. Surgery, 122(2), 255-263.Elsevier. doi: 10.1016/s0039-6060(97)90016-7.
  • Hauser, G.J., Dayao, E.K., Wasserloos, K., Pitt, B.R., & Wong, H.R. (1996). HSP induction inhibits iNOS mRNA expression and attenuates hypotension in endotoxin-challenged rats. Am J Physiol, 271(6 Pt 2), H2529-H2535.American Physiological Society. doi: 10.1152/ajpheart.1996.271.6.H2529.
  • Pitt, B.R., & Robbins, P.D. (1996). Retrovirus-mediated gene therapy to fetal lung. Mol Hum Reprod, 2(7), 467-469.Oxford University Press (OUP). doi: 10.1093/molehr/2.7.467.
  • Wong, H.R., Mannix, R.J., Rusnak, J.M., Boota, A., Zar, H., Watkins, S.C., Lazo, J.S., & Pitt, B.R. (1996). The heat-shock response attenuates lipopolysaccharide-mediated apoptosis in cultured sheep pulmonary artery endothelial cells. Am J Respir Cell Mol Biol, 15(6), 745-751.Oxford University Press (OUP). doi: 10.1165/ajrcmb.15.6.8969269.
  • Pitt, B.R., Schwarz, M.A., Pilewski, J.M., Nakayama, D., Mueller, G.M., Robbins, P.D., Watkins, S.A., Albertine, K.H., & Bland, R.D. (1995). Retrovirus-mediated gene transfer in lungs of living fetal sheep. Gene Ther, 2(5), 344-350.
  • Tyurina, Y.Y., Tyurin, V.A., Yalowich, J.C., Quinn, P.J., Claycamp, H.G., Schor, N.F., Pitt, B.R., & Kagan, V.E. (1995). Phenoxyl radicals of etoposide (VP-16) can directly oxidize intracellular thiols: protective versus damaging effects of phenolic antioxidants. Toxicol Appl Pharmacol, 131(2), 277-288.Elsevier. doi: 10.1006/taap.1995.1070.
  • Wong, H.R., Finder, J.D., Wasserloos, K., & Pitt, B.R. (1995). Expression of iNOS in cultured rat pulmonary artery smooth muscle cells is inhibited by the heat shock response. Am J Physiol, 269(6 Pt 1), L843-L848.American Physiological Society. doi: 10.1152/ajplung.1995.269.6.L843.
  • Evans, R.R., Calmels, T.P., Pitt, B.R., Brookens, M.A., Johnson, C.S., Modzelewski, R.A., & Lazo, J.S. (1994). Gene therapy and endothelial cell targeting for cancer. Ann N Y Acad Sci, 716(1), 257-264.Wiley. doi: 10.1111/j.1749-6632.1994.tb21717.x.
  • Nakayama, D.K., Geller, D.A., Di Silvio, M., Bloomgarden, G., Davies, P., Pitt, B.R., Hatakeyama, K., Kagamiyama, H., Simmons, R.L., & Billiar, T.R. (1994). Tetrahydrobiopterin synthesis and inducible nitric oxide production in pulmonary artery smooth muscle. Am J Physiol, 266(4 Pt 1), L455-L460.American Physiological Society. doi: 10.1152/ajplung.1994.266.4.L455.
  • Schwarz, M.A., Lazo, J.S., Yalowich, J.C., Reynolds, I., Kagan, V.E., Tyurin, V., Kim, Y.M., Watkins, S.C., & Pitt, B.R. (1994). Cytoplasmic metallothionein overexpression protects NIH 3T3 cells from tert-butyl hydroperoxide toxicity. J Biol Chem, 269(21), 15238-15243.Elsevier. doi: 10.1016/s0021-9258(17)36597-3.
  • Weng, W.L., Lazo, J.S., Gillis, C.N., & Pitt, B.R. (1990). Disposition of radioiodinated benzylguanidines in perfused rabbit lung: pharmacokinetics and effect of an organo-gold complexed antineoplastic agent. J Pharmacol Exp Ther, 255(1), 59-65.Elsevier. doi: 10.1016/s0022-3565(25)12787-0.
  • Yeates, D.B., Spektor, D.M., Leikauf, G.D., & Pitt, B.R. (1981). Effects of drugs on mucociliary transport in the trachea and bronchial airways. Chest, 80(6 Suppl), 870-873.Elsevier. doi: 10.1378/chest.80.6.870.
Research Interests
Medical physiology Biochemistry and cell biology Cardiovascular medicine and haematology Clinical sciences Pharmacology and pharmaceutical sciences Medical biotechnology
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Contact Bruce Pitt
Professor
brucep@pitt.edu
Work: (412) 624-8400