Antonio DAmore

Dr. Antonio D’Amore is tenured group leader and head of the RiMED Cardiovascular Tissue Engineering laboratory, the team (currently 23 people strong) operates in two locations: Pittsburgh USA - Pitt and Palermo Italy-RiMED Foundation; Dr D’Amore is also an Associate Professor in the Departments of Surgery and Bioengineering at the University of Pittsburgh and a Full Professor (Chiara Fama) in the Department of Precision Medicine within the School of Medicine, Surgical and Critical Care at the University of Palermo. The research areas of the group he leads include: the development of valve prostheses; vascular grafts; and engineered myocardial walls; quantitative histology; numerical modeling of tissue growth and synthetic material degradation; and bioreactors to simulate tissue engineering and cell proliferation.

 

He earned his master’s degree in Mechanical Engineering from the University of Palermo in 2004 and continued his studies at Imperial College London, where he earned a master’s degree in Biomedical Engineering in 2007. In 2011, Prof. D’Amore earned his Ph.D. in Biomechanics and Tissue Engineering through a joint program between the University of Palermo and the University of Pittsburgh. Since 2008, he has served as a consultant in the field of bioengineering in both the United States and Italy.

  • PhD Biomechanics and tissue engineering, University of Pittsburgh, 2011
  • PhD Biomechanics and tissue engineering, University of Palermo, 2011
  • Master of Science degree in biomedical engineering, Imperial College London, 2007
  • Master of science degree in mechanical Engineering, University of Palermo, 2004

  • Kashiyama, N., Kormos, R.L., Matsumura, Y., D'Amore, A., Miyagawa, S., Sawa, Y., & Wagner, W.R. (2022). Adipose-derived stem cell sheet under an elastic patch improves cardiac function in rats after myocardial infarction. J Thorac Cardiovasc Surg, 163(4), e261-e272.Elsevier. doi: 10.1016/j.jtcvs.2020.04.150.
  • Silveira-Filho, L.M., Coyan, G.N., Adamo, A., Luketich, S.K., Menallo, G., D'Amore, A., & Wagner, W.R. (2021). Can a Biohybrid Patch Salvage Ventricular Function at a Late Time Point in the Post-Infarction Remodeling Process?. JACC Basic Transl Sci, 6(5), 447-463.Elsevier. doi: 10.1016/j.jacbts.2021.01.004.
  • Coyan, G.N., da Mota Silveira-Filho, L., Matsumura, Y., Luketich, S.K., Katz, W., Badhwar, V., Wagner, W.R., & D'Amore, A. (2020). Acute In Vivo Functional Assessment of a Biodegradable Stentless Elastomeric Tricuspid Valve. J Cardiovasc Transl Res, 13(5), 796-805.Springer Nature. doi: 10.1007/s12265-020-09960-z.
  • Mela, P., & D'Amore, A. (2020). In Situ Heart Valve Tissue Engineering: Is Scaffold Structural Biomimicry Overrated?. JACC Basic Transl Sci, 5(12), 1207-1209.Elsevier. doi: 10.1016/j.jacbts.2020.11.009.
  • Coyan, G.N., D'Amore, A., Matsumura, Y., Pedersen, D.D., Luketich, S.K., Shanov, V., Katz, W.E., David, T.E., Wagner, W.R., & Badhwar, V. (2019). In vivo functional assessment of a novel degradable metal and elastomeric scaffold-based tissue engineered heart valve. J Thorac Cardiovasc Surg, 157(5), 1809-1816.Elsevier. doi: 10.1016/j.jtcvs.2018.09.128.
  • Matsumura, Y., Zhu, Y., Jiang, H., D'Amore, A., Luketich, S.K., Charwat, V., Yoshizumi, T., Sato, H., Yang, B., Uchibori, T., Healy, K.E., & Wagner, W.R. (2019). Intramyocardial injection of a fully synthetic hydrogel attenuates left ventricular remodeling post myocardial infarction. Biomaterials, 217, 119289.Elsevier. doi: 10.1016/j.biomaterials.2019.119289.
  • Murdock, M.H., Chang, J.T., Luketich, S.K., Pedersen, D., Hussey, G.S., D'Amore, A., & Badylak, S.F. (2019). Cytocompatibility and mechanical properties of surgical sealants for cardiovascular applications. J Thorac Cardiovasc Surg, 157(1), 176-183.Elsevier. doi: 10.1016/j.jtcvs.2018.08.043.
  • Valencia-Rivero, K.T., Cruz, J.C., Wagner-Gutierrez, N., D'Amore, A., Miranda, M.C., López, R., Guerrero, A., Wagner, W., Sandoval, N., & Briceño, J.C. (2019). Evaluation of Microscopic Structure-Function Relationships of PEGylated Small Intestinal Submucosa Vascular Grafts for Arteriovenous Connection. ACS Appl Bio Mater, 2(9), 3706-3721.American Chemical Society (ACS). doi: 10.1021/acsabm.9b00158.
  • Chen, Y., Ye, S.H., Sato, H., Zhu, Y., Shanov, V., Tiasha, T., D'Amore, A., Luketich, S., Wan, G., & Wagner, W.R. (2018). Hybrid scaffolds of Mg alloy mesh reinforced polymer/extracellular matrix composite for critical-sized calvarial defect reconstruction. J Tissue Eng Regen Med, 12(6), 1374-1388.Wiley. doi: 10.1002/term.2668.
  • D'Amore, A., Fazzari, M., Jiang, H.B., Luketich, S.K., Luketich, M.E., Hoff, R., Jacobs, D.L., Gu, X., Badylak, S.F., Freeman, B.A., & Wagner, W.R. (2018). Nitro-Oleic Acid (NO2-OA) Release Enhances Regional Angiogenesis in a Rat Abdominal Wall Defect Model. Tissue Eng Part A, 24(11-12), 889-904.SAGE Publications. doi: 10.1089/ten.TEA.2017.0349.
  • D'Amore, A., Luketich, S.K., Raffa, G.M., Olia, S., Menallo, G., Mazzola, A., D'Accardi, F., Grunberg, T., Gu, X., Pilato, M., Kameneva, M.V., Badhwar, V., & Wagner, W.R. (2018). Heart valve scaffold fabrication: Bioinspired control of macro-scale morphology, mechanics and micro-structure. Biomaterials, 150, 25-37.Elsevier. doi: 10.1016/j.biomaterials.2017.10.011.
  • D'Amore, A., Nasello, G., Luketich, S.K., Denisenko, D., Jacobs, D.L., Hoff, R., Gibson, G., Bruno, A., T Raimondi, M., & Wagner, W.R. (2018). Meso-scale topological cues influence extracellular matrix production in a large deformation, elastomeric scaffold model. Soft Matter, 14(42), 8483-8495.Royal Society of Chemistry (RSC). doi: 10.1039/c8sm01352g.
  • Haskett, D.G., Saleh, K.S., Lorentz, K.L., Josowitz, A.D., Luketich, S.K., Weinbaum, J.S., Kokai, L.E., D'Amore, A., Marra, K.G., Rubin, J.P., Wagner, W.R., & Vorp, D.A. (2018). An exploratory study on the preparation and evaluation of a "same-day" adipose stem cell-based tissue-engineered vascular graft. J Thorac Cardiovasc Surg, 156(5), 1814-1822.e3.Elsevier. doi: 10.1016/j.jtcvs.2018.05.120.
  • Loneker, A.E., Luketich, S.K., Bernstein, D., Kalra, A., Nugent, A.W., D'Amore, A., & Faulk, D.M. (2018). Mechanical and microstructural analysis of a radially expandable vascular conduit for neonatal and pediatric cardiovascular surgery. J Biomed Mater Res B Appl Biomater, 106(2), 659-671.Wiley. doi: 10.1002/jbm.b.33874.
  • Krawiec, J.T., Liao, H.T., Kwan, L.L., D'Amore, A., Weinbaum, J.S., Rubin, J.P., Wagner, W.R., & Vorp, D.A. (2017). Evaluation of the stromal vascular fraction of adipose tissue as the basis for a stem cell-based tissue-engineered vascular graft. J Vasc Surg, 66(3), 883-890.e1.Elsevier. doi: 10.1016/j.jvs.2016.09.034.
  • Stearns-Reider, K.M., D'Amore, A., Beezhold, K., Rothrauff, B., Cavalli, L., Wagner, W.R., Vorp, D.A., Tsamis, A., Shinde, S., Zhang, C., Barchowsky, A., Rando, T.A., Tuan, R.S., & Ambrosio, F. (2017). Aging of the skeletal muscle extracellular matrix drives a stem cell fibrogenic conversion. Aging Cell, 16(3), 518-528.Wiley. doi: 10.1111/acel.12578.
  • D'Amore, A., Soares, J.S., Stella, J.A., Zhang, W., Amoroso, N.J., Mayer, J.E., Wagner, W.R., & Sacks, M.S. (2016). Large strain stimulation promotes extracellular matrix production and stiffness in an elastomeric scaffold model. J Mech Behav Biomed Mater, 62, 619-635.Elsevier. doi: 10.1016/j.jmbbm.2016.05.005.
  • D'Amore, A., Yoshizumi, T., Luketich, S.K., Wolf, M.T., Gu, X., Cammarata, M., Hoff, R., Badylak, S.F., & Wagner, W.R. (2016). Bi-layered polyurethane - Extracellular matrix cardiac patch improves ischemic ventricular wall remodeling in a rat model. Biomaterials, 107, 1-14.Elsevier. doi: 10.1016/j.biomaterials.2016.07.039.
  • Krawiec, J.T., Weinbaum, J.S., Liao, H.T., Ramaswamy, A.K., Pezzone, D.J., Josowitz, A.D., D'Amore, A., Rubin, J.P., Wagner, W.R., & Vorp, D.A. (2016). In Vivo Functional Evaluation of Tissue-Engineered Vascular Grafts Fabricated Using Human Adipose-Derived Stem Cells from High Cardiovascular Risk Populations. Tissue Eng Part A, 22(9-10), 765-775.SAGE Publications. doi: 10.1089/ten.TEA.2015.0379.
  • Loneker, A.E., Faulk, D.M., Hussey, G.S., D'Amore, A., & Badylak, S.F. (2016). Solubilized liver extracellular matrix maintains primary rat hepatocyte phenotype in-vitro. J Biomed Mater Res A, 104(4), 957-965.Wiley. doi: 10.1002/jbm.a.35636.
  • Takanari, K., Hong, Y., Hashizume, R., Huber, A., Amoroso, N.J., D'Amore, A., Badylak, S.F., & Wagner, W.R. (2016). Abdominal wall reconstruction by a regionally distinct biocomposite of extracellular matrix digest and a biodegradable elastomer. J Tissue Eng Regen Med, 10(9), 748-761.Hindawi. doi: 10.1002/term.1834.
  • Tsamis, A., Phillippi, J.A., Koch, R.G., Chan, P.G., Krawiec, J.T., D'Amore, A., Watkins, S.C., Wagner, W.R., Vorp, D.A., & Gleason, T.G. (2016). Extracellular matrix fiber microarchitecture is region-specific in bicuspid aortic valve-associated ascending aortopathy. J Thorac Cardiovasc Surg, 151(6), 1718-1728.e5.Elsevier. doi: 10.1016/j.jtcvs.2016.02.019.
  • Carleton, J.B., D'Amore, A., Feaver, K.R., Rodin, G.J., & Sacks, M.S. (2015). Geometric characterization and simulation of planar layered elastomeric fibrous biomaterials. Acta Biomater, 12(1), 93-101.Elsevier. doi: 10.1016/j.actbio.2014.09.049.
  • Hemmasizadeh, A., Tsamis, A., Cheheltani, R., Assari, S., D'Amore, A., Autieri, M., Kiani, M.F., Pleshko, N., Wagner, W.R., Watkins, S.C., Vorp, D., & Darvish, K. (2015). Correlations between transmural mechanical and morphological properties in porcine thoracic descending aorta. J Mech Behav Biomed Mater, 47, 12-20.Elsevier. doi: 10.1016/j.jmbbm.2015.03.004.
  • Hobson, C.M., Amoroso, N.J., Amini, R., Ungchusri, E., Hong, Y., D'Amore, A., Sacks, M.S., & Wagner, W.R. (2015). Fabrication of elastomeric scaffolds with curvilinear fibrous structures for heart valve leaflet engineering. J Biomed Mater Res A, 103(9), 3101-3106.Wiley. doi: 10.1002/jbm.a.35450.
  • D'Amore, A., Amoroso, N., Gottardi, R., Hobson, C., Carruthers, C., Watkins, S., Wagner, W.R., & Sacks, M.S. (2014). From single fiber to macro-level mechanics: A structural finite-element model for elastomeric fibrous biomaterials. J Mech Behav Biomed Mater, 39, 146-161.Elsevier. doi: 10.1016/j.jmbbm.2014.07.016.
  • Koch, R.G., Tsamis, A., D'Amore, A., Wagner, W.R., Watkins, S.C., Gleason, T.G., & Vorp, D.A. (2014). A custom image-based analysis tool for quantifying elastin and collagen micro-architecture in the wall of the human aorta from multi-photon microscopy. J Biomech, 47(5), 935-943.Elsevier. doi: 10.1016/j.jbiomech.2014.01.027.
  • Pal, S., Tsamis, A., Pasta, S., D'Amore, A., Gleason, T.G., Vorp, D.A., & Maiti, S. (2014). A mechanistic model on the role of "radially-running" collagen fibers on dissection properties of human ascending thoracic aorta. J Biomech, 47(5), 981-988.Elsevier. doi: 10.1016/j.jbiomech.2014.01.005.
  • Task, K., D'Amore, A., Singh, S., Candiello, J., Jaramillo, M., Wagner, W.R., Kumta, P., & Banerjee, I. (2014). Systems level approach reveals the correlation of endoderm differentiation of mouse embryonic stem cells with specific microstructural cues of fibrin gels. J R Soc Interface, 11(95), 20140009.The Royal Society. doi: 10.1098/rsif.2014.0009.
  • Ye, S.H., Hong, Y., Sakaguchi, H., Shankarraman, V., Luketich, S.K., D'Amore, A., & Wagner, W.R. (2014). Nonthrombogenic, biodegradable elastomeric polyurethanes with variable sulfobetaine content. ACS Appl Mater Interfaces, 6(24), 22796-22806.American Chemical Society (ACS). doi: 10.1021/am506998s.
  • Sacks, M., D’Amore, A., & Hobson, C. (2013). Finite Element Analysis in Biomechanics. In Biomaterials Science. (pp. 21-34).Elsevier. doi: 10.1016/b978-0-08-087780-8.00004-8.
  • Amoroso, N.J., D'Amore, A., Hong, Y., Rivera, C.P., Sacks, M.S., & Wagner, W.R. (2012). Microstructural manipulation of electrospun scaffolds for specific bending stiffness for heart valve tissue engineering. Acta Biomater, 8(12), 4268-4277.Elsevier. doi: 10.1016/j.actbio.2012.08.002.
  • Sacks, M.S., Wognum, S., Stella, J., Joyce, E., & D'Amore, A. (2011). The mechanics of native and engineered cardiac soft tissues. In Comprehensive Biomaterials. 3, (pp. 113-132).
  • D'Amore, A., Stella, J.A., Wagner, W.R., & Sacks, M.S. (2010). Characterization of the complete fiber network topology of planar fibrous tissues and scaffolds. Biomaterials, 31(20), 5345-5354.Elsevier. doi: 10.1016/j.biomaterials.2010.03.052.
  • Stella, J.A., D'Amore, A., Wagner, W.R., & Sacks, M.S. (2010). On the biomechanical function of scaffolds for engineering load-bearing soft tissues. Acta Biomater, 6(7), 2365-2381.Elsevier. doi: 10.1016/j.actbio.2010.01.001.
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  • Hettinger, S.
  • Oishi, K.
  • Pedersen, K.
  • Barbuto, A.
  • D.
  • Chia Wang; M.
  • Filiciani, L.
  • C.
  • Pasqua, M.
  • Vella, P.
  • Boodagh*, L.
  • Hayashi, S.
  • Hayashi, T.
  • A versatile 5-axis melt Page 23 of 42 electrowriting platform for unprecedented design freedom of 3D fibrous scaffolds.
  • Zhu, S.
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  • Menallo, R.
  • Pedersen, S.
  • Machaidze, A.
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  • Kim; A.
  • Sato, K.
  • Rodriguez-Soto; A.M.
  • Adamo, J.
  • K.
  • Adamo, A.
  • M.
  • Kawakami, K.
  • Mela, A.
  • M.
  • Kashiyama, R.
  • Coyan, L.
  • Matsumura, Y.
  • K.Valencia-Rivero, J.
  • D’Amore, S.
  • N.
  • Murdock, J.
  • D’Amore, G.
  • G Haskett, K.
  • Ye, Y.
  • D’Amore, M.
  • D’Amore, S.
  • Stearns-Reider , A.
  • Loneker, S.
  • T.
  • D’Amore, T.
  • Takanari, Y.
  • D’Amore*, J.
  • Krawiec, H.
  • Phillippi, R.
  • Loneker, D.
  • Yoshizumi, Y.
  • Pasta, J.
  • Zhang, R.
  • Liang, G.
  • Hemmasizadeh, A.
  • Hobson, N.
  • Ye, Y.
  • Carleton, A.
  • D’Amore, N.
  • M.
  • Task, A.
  • Koch, A.
  • Pal, A.
  • Faulk, C.
  • Tsamis, J.
  • Keane, R.
  • Wolf, K.
  • Amoroso, A.
  • Amoroso, A.
  • D’Amore, J.
  • Stella, A.

  • Koch, R.G., Tsamis, A., D’Amore, A., Wagner, W.R., & Vorp, D.A. (2013). A Custom Image-Based Analysis Tool for Quantifying Elastin and Collagen Fiber Micro-Architecture in the Wall of the Human Aorta From Multi-Photon Microscopy Images. Poster session presented at the meeting of Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions.Sunriver, OR.
  • Tsamis, A., Phillippi, J.A., Koch, R.G., Krawiec, J.T., D’Amore, A., Watkins, S.C., Wagner, W.R., Vorp, D.A., & Gleason, T.G. (2013). Region-Specific Medial Fiber Micro-Architecture in the Longitudinal-Radial and Circumferential-Radial Planes of Ascending Thoracic Aortic Aneurysm Among Bicuspid and Tricuspid Aortic Valve Patients. In Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments, 1 A, (p. v01at01a002).ASME International. doi: 10.1115/sbc2013-14403.
  • Carruthers, C.A., Good, B., D’Amore, A., Liao, J., Amini, R., Watkins, S.C., & Sacks, M.S. (2012). Alterations in the Microstructure of the Anterior Mitral Valve Leaflet Under Physiological Stress. In ASME 2012 Summer Bioengineering Conference, Parts A and B, (pp. 227-228).ASME International. doi: 10.1115/sbc2012-80820.
  • Carruthers, C.A., Good, B., D’Amore, A., Amini, R., Gorman, J.H., & Sacks, M.S. (2011). Physiological Micromechanics of the Anterior Mitral Valve Leaflet. In ASME 2011 Summer Bioengineering Conference, Parts A and B, (PARTS A AND B), (pp. 237-238).ASME International. doi: 10.1115/sbc2011-53637.
  • D’Amore, A., Stella, J.A., Schmidt, D.E., Wagner, W.R., & Sacks, M.S. (2010). A Micro-Architectural Based Structural Model for Elastomeric Electrospun Scaffolds. In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology, (pp. 181-182).ASME International. doi: 10.1115/nemb2010-13344.
  • D’Amore, A., Stella, J.A., Wagner, W.R., & Sacks, M.S. (2010). A Method to Extract the Complete Fiber Network Topology of Planar Fibrous Tissues and Scaffolds. In ASME 2010 Summer Bioengineering Conference, Parts A and B, (PARTS A AND B), (pp. 367-368).ASME International. doi: 10.1115/sbc2010-19166.
  • D’Amore, A., Stella, J.A., Schmidt, D.E., Wagner, W.R., & Sacks, M.S. (2009). Micro-Meso Scale Model of Electrospun Poly (Ester Urethane) Urea Scaffolds. In ASME 2009 Summer Bioengineering Conference, Parts A and B, (PART A), (pp. 89-90).ASME International. doi: 10.1115/sbc2009-205531.
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