headshot of Xinyan Tracy Cui

Xinyan Tracy Cui

Dr. Cui's Lab Website Bioengineering Department


(2013 - 2014) PKU Engineering Globex Fellow.

(2013) Carnegie Science Award Emerging Female Scientist.

(2013) Visiting Professor, Taiyuan Institute of Technology.

(2008 - 2013) National Science Foundation Career Award.

(2005 - 2007) The Wallace Coulter Foundation Early Career Award.

(2000) Charles G. Overberger Award for Research Excellence.

(1999) Alfred P. Sloan Fellowship Award.

PhD, Macromolecular Science and Engineering, University of Michigan, 1998 - 2002

MS, Biophysics, Tsinghua University, 1994 - 1997

BS, Polymer Materials and Chemical Engineering, Tsinghua University, 1989 - 1994

Dhawan, V., Martin, P.N., Hu, X., & Cui, X.T. (2024). Investigation of a chondroitin sulfate-based bioactive coating for neural interface applications. J Mater Chem B.Royal Society of Chemistry (RSC). doi: 10.1039/d4tb00501e.

Faul, E.B.A., Broussard, A.M., Rivera, D.R., Pwint, M.Y., Wu, B., Cao, Q., Bailey, D., Cui, X.T., & Castagnola, E. (2024). Batch Fabrication of Microelectrode Arrays with Glassy Carbon Microelectrodes and Interconnections for Neurochemical Sensing: Promises and Challenges. Micromachines (Basel), 15(2), 277.MDPI AG. doi: 10.3390/mi15020277.

Woeppel, K.M., Krahe, D.D., Robbins, E.M., Vazquez, A.L., & Cui, X.T. (2024). Electrically Controlled Vasodilator Delivery from PEDOT/Silica Nanoparticle Modulates Vessel Diameter in Mouse Brain. Adv Healthc Mater, 13(3), e2301221.Wiley. doi: 10.1002/adhm.202301221.

Wu, B., Castagnola, E., McClung, C.A., & Cui, X.T. (2024). PEDOT/CNT Flexible MEAs Reveal New Insights into the Clock Gene's Role in Dopamine Dynamics. Adv Sci (Weinh), e2308212.Wiley. doi: 10.1002/advs.202308212.

Yang, Q., Wu, B., Castagnola, E., Pwint, M.Y., Williams, N.P., Vazquez, A.L., & Cui, X.T. (2024). Integrated Microprism and Microelectrode Array for Simultaneous Electrophysiology and Two-Photon Imaging across All Cortical Layers. Adv Healthc Mater, e2302362.Wiley. doi: 10.1002/adhm.202302362.

Castagnola, E., Robbins, E.M., Krahe, D.D., Wu, B., Pwint, M.Y., Cao, Q., & Cui, X.T. (2023). Stable in-vivo electrochemical sensing of tonic serotonin levels using PEDOT/CNT-coated glassy carbon flexible microelectrode arrays. BIOSENSORS & BIOELECTRONICS, 230, 115242.Elsevier BV. doi: 10.1016/j.bios.2023.115242.

Ruhunage, C., Dhawan, V., Nawarathne, C.P., Hoque, A., Cui, X.T., & Alvarez, N.T. (2023). Evaluation of Polymer-Coated Carbon Nanotube Flexible Microelectrodes for Biomedical Applications. BIOENGINEERING-BASEL, 10(6), 647.MDPI AG. doi: 10.3390/bioengineering10060647.

Salavatian, S., Robbins, E.M., Kuwabara, Y., Castagnola, E., Cui, X.T., & Mahajan, A. (2023). Real-time in vivo thoracic spinal glutamate sensing during myocardial ischemia. Am J Physiol Heart Circ Physiol, 325(6), H1304-H1317.American Physiological Society. doi: 10.1152/ajpheart.00299.2023.

Woeppel, K., Dhawan, V., Shi, D., & Cui, X.T. (2023). Nanotopography-enhanced biomimetic coating maintains bioactivity after weeks of dry storage and improves chronic neural recording. BIOMATERIALS, 302, 122326.Elsevier BV. doi: 10.1016/j.biomaterials.2023.122326.

Wu, B., Castagnola, E., & Cui, X.T. (2023). Zwitterionic Polymer Coated and Aptamer Functionalized Flexible Micro-Electrode Arrays for In Vivo Cocaine Sensing and Electrophysiology. MICROMACHINES, 14(2), 323.MDPI AG. doi: 10.3390/mi14020323.

Yang, Q., & Cui, X.T. (2023). Advanced in vivo fluorescence microscopy of neural electronic interface. MRS BULLETIN, 48(5), 506-517.Springer Science and Business Media LLC. doi: 10.1557/s43577-023-00530-7.

Castagnola, E., Robbins, E.M., Wu, B., Pwint, M.Y., Garg, R., Cohen-Karni, T., & Cui, X.T. (2022). Flexible Glassy Carbon Multielectrode Array for In Vivo Multisite Detection of Tonic and Phasic Dopamine Concentrations. BIOSENSORS-BASEL, 12(7), 540.MDPI AG. doi: 10.3390/bios12070540.

Dhawan, V., & Cui, X.T. (2022). Carbohydrate based biomaterials for neural interface applications. JOURNAL OF MATERIALS CHEMISTRY B, 10(25), 4714-4740.Royal Society of Chemistry (RSC). doi: 10.1039/d2tb00584k.

Ding, R., Miller, N.C., Woeppel, K.M., Cui, X.T., & Jacobs, T.D.B. (2022). Surface Area and Local Curvature: Why Roughness Improves the Bioactivity of Neural Implants. LANGMUIR, 38(24), 7512-7521.American Chemical Society (ACS). doi: 10.1021/acs.langmuir.2c00473.

Krahe, D.D., Woeppel, K.M., Yang, Q., Kushwah, N., & Cui, X.T. (2022). Melatonin Decreases Acute Inflammatory Response to Neural Probe Insertion. ANTIOXIDANTS, 11(8), 1628.MDPI AG. doi: 10.3390/antiox11081628.

Kushwah, N., Woeppel, K., Dhawan, V., Shi, D., & Cui, X.T. (2022). Effects of neuronal cell adhesion molecule L1 and nanoparticle surface modification on microglia. ACTA BIOMATERIALIA, 149, 273-286.Elsevier BV. doi: 10.1016/j.actbio.2022.06.038.

Ruhunage, C.K., Dhawan, V., McKenzie, T.J., Hoque, A., Rahm, C.E., Nawarathne, C.P., Ayres, N., Cui, X.T., & Alvarez, N.T. (2022). Hydrophilic Micro- and Macroelectrodes with Antibiofouling Properties for Biomedical Applications. ACS BIOMATERIALS SCIENCE & ENGINEERING, 8(7), 2920-2931.American Chemical Society (ACS). doi: 10.1021/acsbiomaterials.2c00173.

Zheng, X.S., Yang, Q., Vazquez, A., & Cui, X.T. (2022). Imaging the stability of chronic electrical microstimulation using electrodes coated with PEDOT/CNT and iridium oxide. ISCIENCE, 25(7), 104539.Elsevier BV. doi: 10.1016/j.isci.2022.104539.

Ahmed, M.N., Shi, D., Dailey, M.T., Rothermund, K., Drewry, M.D., Calabrese, T.C., Cui, X.T., & Syed-Picard, F.N. (2021). Dental Pulp Cell Sheets Enhance Facial Nerve Regeneration via Local Neurotrophic Factor Delivery. TISSUE ENGINEERING PART A, 27(17-18), 1128-1139.Mary Ann Liebert Inc. doi: 10.1089/ten.tea.2020.0265.

Castagnola, E., Garg, R., Rastogi, S.K., Cohen-Karni, T., & Cui, X.T. (2021). 3D fuzzy graphene microelectrode array for dopamine sensing at sub-cellular spatial resolution. BIOSENSORS & BIOELECTRONICS, 191, 113440.Elsevier BV. doi: 10.1016/j.bios.2021.113440.

Krishnan, A., Forssell, M., Du, Z., Cui, X.T., Fedder, G.K., & Kelly, S.K. (2021). Residual voltage as an ad-hoc indicator of electrode damage in biphasic electrical stimulation. JOURNAL OF NEURAL ENGINEERING, 18(4), 0460c1.IOP Publishing. doi: 10.1088/1741-2552/ac028a.

Shi, D., Dhawan, V., & Cui, X.T. (2021). Bio-integrative design of the neural tissue-device interface. CURRENT OPINION IN BIOTECHNOLOGY, 72, 54-61.Elsevier BV. doi: 10.1016/j.copbio.2021.10.003.

Tan, C., Kushwah, N., & Cui, X.T. (2021). Electrically Controlled Neurochemical Delivery from Microelectrodes for Focal and Transient Modulation of Cellular Behavior. BIOSENSORS-BASEL, 11(9), 348.MDPI AG. doi: 10.3390/bios11090348.

Tan, C., Robbins, E.M., Wu, B., & Cui, X.T. (2021). Recent Advances in In Vivo Neurochemical Monitoring. MICROMACHINES, 12(2), 208.MDPI AG. doi: 10.3390/mi12020208.

Woeppel, K.M., & Cui, X.T. (2021). Nanoparticle and Biomolecule Surface Modification Synergistically Increases Neural Electrode Recording Yield and Minimizes Inflammatory Host Response. ADVANCED HEALTHCARE MATERIALS, 10(16), e2002150.Wiley. doi: 10.1002/adhm.202002150.

Yang, Q., Vazquez, A.L., & Cui, X.T. (2021). Long-term in vivo two-photon imaging of the neuroinflammatory response to intracortical implants and micro-vessel disruptions in awake mice. BIOMATERIALS, 276, 121060.Elsevier BV. doi: 10.1016/j.biomaterials.2021.121060.

Zheng, X.S., Tan, C., Castagnola, E., & Cui, X.T. (2021). Electrode Materials for Chronic Electrical Microstimulation. ADVANCED HEALTHCARE MATERIALS, 10(12), e2100119.Wiley. doi: 10.1002/adhm.202100119.

Castagnola, E., Robbins, E.M., Woeppel, K.M., McGuier, M., Golabchi, A., Taylor, I.M., Michael, A.C., & Cui, X.T. (2020). Real-Time Fast Scan Cyclic Voltammetry Detection and Quantification of Exogenously Administered Melatonin in Mice Brain. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 8, 602216.Frontiers Media SA. doi: 10.3389/fbioe.2020.602216.

Castagnola, E., Woeppel, K., Golabchi, A., McGuier, M., Chodapaneedi, N., Metro, J., Taylor, I.M., & Cui, X.T. (2020). Electrochemical detection of exogenously administered melatonin in the brain. ANALYST, 145(7), 2612-2620.Royal Society of Chemistry (RSC). doi: 10.1039/d0an00051e.

Golabchi, A., Woeppel, K.M., Li, X., Lagenaur, C.F., & Cui, X.T. (2020). Neuroadhesive protein coating improves the chronic performance of neuroelectronics in mouse brain. BIOSENSORS & BIOELECTRONICS, 155, 112096.Elsevier BV. doi: 10.1016/j.bios.2020.112096.

Kolarcik, C.L., Castro, C.A., Lesniak, A., Demetris, A.J., Fisher, L.E., Gaunt, R.A., Weber, D.J., & Cui, X.T. (2020). Host tissue response to floating microelectrode arrays chronically implanted in the feline spinal nerve. JOURNAL OF NEURAL ENGINEERING, 17(4), 046012.IOP Publishing. doi: 10.1088/1741-2552/ab94d7.

Yang, Q., Wu, B., Eles, J.R., Vazquez, A.L., Kozai, T.D.Y., & Cui, X.T. (2020). Zwitterionic Polymer Coating Suppresses Microglial Encapsulation to Neural Implants In Vitro and In Vivo. ADVANCED BIOSYSTEMS, 4(6), e1900287.Wiley. doi: 10.1002/adbi.201900287.

Zheng, X.S., Griffith, A.Y., Chang, E., Looker, M.J., Fisher, L.E., Clapsaddle, B., & Cui, X.T. (2020). Evaluation of a conducting elastomeric composite material for intramuscular electrode application. ACTA BIOMATERIALIA, 103, 81-91.Elsevier BV. doi: 10.1016/j.actbio.2019.12.021.

Eles, J.R., Vazquez, A.L., Kozai, T.D.Y., & Cui, X.T. (2019). Meningeal inflammatory response and fibrous tissue remodeling around intracortical implants: An in vivo two-photon imaging study. BIOMATERIALS, 195, 111-123.Elsevier BV. doi: 10.1016/j.biomaterials.2018.12.031.

Golabchi, A., Wu, B., Cao, B., Bettinger, C.J., & Cui, X.T. (2019). Zwitterionic polymer/polydopamine coating reduce acute inflammatory tissue responses to neural implants. Biomaterials, 225, 119519.Elsevier BV. doi: 10.1016/j.biomaterials.2019.119519.

Gong, X., Zhang, L., Liu, Y., Wang, H., Cui, X., Hu, Q., Song, S., Shuang, S., & Dong, C. (2019). Controllable Fabrication, Photoluminescence Mechanism, and Novel Application of Green-Yellow-Orange Fluorescent Carbon-Based Nanodots. ACS BIOMATERIALS SCIENCE & ENGINEERING, 5(10), 5060-5071.American Chemical Society (ACS). doi: 10.1021/acsbiomaterials.9b01153.

Hou, L., Li, F., Guo, J., Zhang, X., Kong, X., Cui, X.T., Dong, C., Wang, Y., & Shuang, S. (2019). A colorimetric and ratiometric fluorescent probe for cyanide sensing in aqueous media and live cells. JOURNAL OF MATERIALS CHEMISTRY B, 7(30), 4620-4629.Royal Society of Chemistry (RSC). doi: 10.1039/c9tb00842j.

Lu, W., Du, F., Zhao, X., Shi, L., Shuang, S., Cui, X.T., & Dong, C. (2019). Sulforaphane-Conjugated Carbon Dots: A Versatile Nanosystem for Targeted Imaging and Inhibition of EGFR-Overexpressing Cancer Cells. ACS BIOMATERIALS SCIENCE & ENGINEERING, 5(9), 4692-4699.American Chemical Society (ACS). doi: 10.1021/acsbiomaterials.9b00690.

Taylor, I.M., Patel, N.A., Freedman, N.C., Castagnola, E., & Cui, X.T. (2019). Direct in Vivo Electrochemical Detection of Resting Dopamine Using Poly(3,4-ethylenedioxythiophene)/Carbon Nanotube Functionalized Microelectrodes. ANALYTICAL CHEMISTRY, 91(20), 12917-12927.American Chemical Society (ACS). doi: 10.1021/acs.analchem.9b02904.

Woeppel, K.M., Zheng, X.S., Schulte, Z.M., Rosi, N.L., & Cui, X.T. (2019). Nanoparticle Doped PEDOT for Enhanced Electrode Coatings and Drug Delivery. ADVANCED HEALTHCARE MATERIALS, 8(21), e1900622.Wiley. doi: 10.1002/adhm.201900622.

Wu, B., Cao, B., Taylor, I.M., Woeppel, K., & Cui, X.T. (2019). Facile Synthesis of a 3,4-Ethylene-Dioxythiophene (EDOT) Derivative for Ease of Bio-Functionalization of the Conducting Polymer PEDOT. FRONTIERS IN CHEMISTRY, 7(MAR), 178.Frontiers Media SA. doi: 10.3389/fchem.2019.00178.

Zheng, X., Woeppel, K.M., Griffith, A.Y., Chang, E., Looker, M.J., Fisher, L.E., Clapsaddle, B.J., & Cui, X.T. (2019). Soft Conducting Elastomer for Peripheral Nerve Interface. ADVANCED HEALTHCARE MATERIALS, 8(9), e1801311.Wiley. doi: 10.1002/adhm.201801311.

Zheng, X.S., Snyder, N.R., Woeppel, K., Barengo, J.H., Li, X., Eles, J., Kolarcik, C.L., & Cui, X.T. (2019). A superoxide scavenging coating for improving tissue response to neural implants. ACTA BIOMATERIALIA, 99, 72-83.Elsevier BV. doi: 10.1016/j.actbio.2019.08.032.

Catt, K., Li, H., Hoang, V., Beard, R., & Cui, X.T. (2018). Self-powered therapeutic release from conducting polymer/graphene oxide films on magnesium. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 14(7), 2495-2503.Elsevier BV. doi: 10.1016/j.nano.2017.02.021.

Cody, P.A., Eles, J.R., Lagenaur, C.F., Kozai, T.D.Y., & Cui, X.T. (2018). Unique electrophysiological and impedance signatures between encapsulation types: An analysis of biological Utah array failure and benefit of a biomimetic coating in a rat model. BIOMATERIALS, 161, 117-128.Elsevier BV. doi: 10.1016/j.biomaterials.2018.01.025.

Du, Z.J., Bi, G., & Cui, X.T. (2018). Electrically Controlled Neurochemical Release from Dual‐Layer Conducting Polymer Films for Precise Modulation of Neural Network Activity in Rat Barrel Cortex. Advanced Functional Materials, 28(12).Wiley. doi: 10.1002/adfm.201703988.

Eles, J.R., Vazquez, A.L., Kozai, T.D.Y., & Cui, X.T. (2018). In vivo imaging of neuronal calcium during electrode implantation: Spatial and temporal mapping of damage and recovery. BIOMATERIALS, 174, 79-94.Elsevier BV. doi: 10.1016/j.biomaterials.2018.04.043.

Golabchi, A., Wu, B., Li, X., Carlisle, D.L., Kozai, T.D.Y., Friedlander, R.M., & Cui, X.T. (2018). Melatonin improves quality and longevity of chronic neural recording. BIOMATERIALS, 180, 225-239.Elsevier BV. doi: 10.1016/j.biomaterials.2018.07.026.

Michelson, N.J., Vazquez, A.L., Eles, J.R., Salatino, J.W., Purcell, E.K., Williams, J.J., Cui, X.T., & Kozai, T.D.Y. (2018). Multi-scale, multi-modal analysis uncovers complex relationship at the brain tissue-implant neural interface: new emphasis on the biological interface. JOURNAL OF NEURAL ENGINEERING, 15(3), 033001.IOP Publishing. doi: 10.1088/1741-2552/aa9dae.

Patel, A., Xue, Y., Hartley, R., Sant, V., Eles, J.R., Cui, X.T., Stolz, D.B., & Sant, S. (2018). Hierarchically aligned fibrous hydrogel films through microfluidic self-assembly of graphene and polysaccharides. BIOTECHNOLOGY AND BIOENGINEERING, 115(10), 2654-2667.Wiley. doi: 10.1002/bit.26801.

Shen, Y., Cao, B., Snyder, N.R., Woeppel, K.M., Eles, J.R., & Cui, X.T. (2018). ROS responsive resveratrol delivery from LDLR peptide conjugated PLA-coated mesoporous silica nanoparticles across the blood-brain barrier. JOURNAL OF NANOBIOTECHNOLOGY, 16(1), 13.Springer Science and Business Media LLC. doi: 10.1186/s12951-018-0340-7.

Woeppel, K.M., Zheng, X.S., & Cui, X.T. (2018). Enhancing surface immobilization of bioactive molecules via a silica nanoparticle based coating. JOURNAL OF MATERIALS CHEMISTRY B, 6(19), 3058-3067.Royal Society of Chemistry (RSC). doi: 10.1039/c8tb00408k.

Catt, K., Li, H., & Cui, X.T. (2017). Poly (3,4-ethylenedioxythiophene) graphene oxide composite coatings for controlling magnesium implant corrosion. ACTA BIOMATERIALIA, 48, 530-540.Elsevier BV. doi: 10.1016/j.actbio.2016.11.039.

Du, Z.J., Kolarcik, C.L., Kozai, T.D.Y., Luebben, S.D., Sapp, S.A., Zheng, X.S., Nabity, J.A., & Cui, X.T. (2017). Ultrasoft microwire neural electrodes improve chronic tissue integration. ACTA BIOMATERIALIA, 53, 46-58.Elsevier BV. doi: 10.1016/j.actbio.2017.02.010.

Eles, J.R., Vazquez, A.L., Snyder, N.R., Lagenaur, C., Murphy, M.C., Kozai, T.D.Y., & Cui, X.T. (2017). Neuroadhesive L1 coating attenuates acute microglial attachment to neural electrodes as revealed by live two-photon microscopy. BIOMATERIALS, 113, 279-292.Elsevier BV. doi: 10.1016/j.biomaterials.2016.10.054.

Taylor, I.M., Du, Z., Bigelow, E.T., Eles, J.R., Horner, A.R., Catt, K.A., Weber, S.G., Jamieson, B.G., & Cui, X.T. (2017). Aptamer-functionalized neural recording electrodes for the direct measurement of cocaine in vivo. JOURNAL OF MATERIALS CHEMISTRY B, 5(13), 2445-2458.Royal Society of Chemistry (RSC). doi: 10.1039/c7tb00095b.

Taylor, I.M., Robbins, E.M., Catt, K.A., Cody, P.A., Happe, C.L., & Cui, X.T. (2017). Enhanced dopamine detection sensitivity by PEDOT/graphene oxide coating on in vivo carbon fiber electrodes. BIOSENSORS & BIOELECTRONICS, 89(Pt 1), 400-410.Elsevier BV. doi: 10.1016/j.bios.2016.05.084.

Woeppel, K., Yang, Q., & Cui, X.T. (2017). Recent Advances in Neural Electrode-Tissue Interfaces. Curr Opin Biomed Eng, 4, 21-31.Elsevier BV. doi: 10.1016/j.cobme.2017.09.003.

Degenhart, A.D., Eles, J., Dum, R., Mischel, J.L., Smalianchuk, I., Endler, B., Ashmore, R.C., Tyler-Kabara, E.C., Hatsopoulos, N.G., Wang, W., Batista, A.P., & Cui, X.T. (2016). Histological evaluation of a chronically-implanted electrocorticographic electrode grid in a non-human primate. JOURNAL OF NEURAL ENGINEERING, 13(4), 046019.IOP Publishing. doi: 10.1088/1741-2560/13/4/046019.

Khilwani, R., Gilgunn, P.J., Kozai, T.D.Y., Ong, X.C., Korkmaz, E., Gunalan, P.K., Cui, X.T., Fedder, G.K., & Ozdoganlar, O.B. (2016). Ultra-miniature ultra-compliant neural probes with dissolvable delivery needles: design, fabrication and characterization. BIOMEDICAL MICRODEVICES, 18(6), 97.Springer Science and Business Media LLC. doi: 10.1007/s10544-016-0125-4.

Kozai, T.D.Y., Catt, K., Du, Z., Na, K., Srivannavit, O., Haque, R.U.M., Seymour, J., Wise, K.D., Yoon, E., & Cui, X.T. (2016). Chronic In Vivo Evaluation of PEDOT/CNT for Stable Neural Recordings. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 63(1), 111-119.Institute of Electrical and Electronics Engineers (IEEE). doi: 10.1109/TBME.2015.2445713.

Kozai, T.D.Y., Eles, J.R., Vazquez, A.L., & Cui, X.T. (2016). Two-photon imaging of chronically implanted neural electrodes: Sealing methods and new insights. JOURNAL OF NEUROSCIENCE METHODS, 258, 46-55.Elsevier BV. doi: 10.1016/j.jneumeth.2015.10.007.

Kozai, T.D.Y., Jaquins-Gerstl, A.S., Vazquez, A.L., Michael, A.C., & Cui, X.T. (2016). Dexamethasone retrodialysis attenuates microglial response to implanted probes in vivo. BIOMATERIALS, 87, 157-169.Elsevier BV. doi: 10.1016/j.biomaterials.2016.02.013.

Alba, N.A., Du, Z.J., Catt, K.A., Kozai, T.D.Y., & Cui, X.T. (2015). In Vivo Electrochemical Analysis of a PEDOT/MWCNT Neural Electrode Coating. Biosensors (Basel), 5(4), 618-646.MDPI AG. doi: 10.3390/bios5040618.

Du, Z.J., Luo, X., Weaver, C.L., & Cui, X.T. (2015). Poly(3,4-ethylenedioxythiophene)-ionic liquid coating improves neural recording and stimulation functionality of MEAs. JOURNAL OF MATERIALS CHEMISTRY C, 3(25), 6515-6524.Royal Society of Chemistry (RSC). doi: 10.1039/c5tc00145e.

Kolarcik, C.L., Catt, K., Rost, E., Albrecht, I.N., Bourbeau, D., Du, Z., Kozai, T.D.Y., Luo, X., Weber, D.J., & Cui, X.T. (2015). Evaluation of poly(3,4-ethylenedioxythiophene)/carbon nanotube neural electrode coatings for stimulation in the dorsal root ganglion. JOURNAL OF NEURAL ENGINEERING, 12(1), 016008.IOP Publishing. doi: 10.1088/1741-2560/12/1/016008.

Kolarcik, C.L., Luebben, S.D., Sapp, S.A., Hanner, J., Snyder, N., Kozai, T.D.Y., Chang, E., Nabity, J.A., Nabity, S.T., Lagenaur, C.F., & Cui, X.T. (2015). Elastomeric and soft conducting microwires for implantable neural interfaces. SOFT MATTER, 11(24), 4847-4861.Royal Society of Chemistry (RSC). doi: 10.1039/c5sm00174a.

Kozai, T.D.Y., Catt, K., Li, X., Gugel, Z.V., Olafsson, V.T., Vazquez, A.L., & Cui, X.T. (2015). Mechanical failure modes of chronically implanted planar silicon-based neural probes for laminar recording. BIOMATERIALS, 37, 25-39.Elsevier BV. doi: 10.1016/j.biomaterials.2014.10.040.

Kozai, T.D.Y., Jaquins-Gerstl, A.S., Vazquez, A.L., Michael, A.C., & Cui, X.T. (2015). Brain Tissue Responses to Neural Implants Impact Signal Sensitivity and Intervention Strategies. ACS CHEMICAL NEUROSCIENCE, 6(1), 48-67.American Chemical Society (ACS). doi: 10.1021/cn500256e.

Rozai, T.D.Y., Du, Z., Gugel, Z.V., Smith, M.A., Chase, S.M., Bodily, L.M., Caparosa, E.M., Friedlander, R.M., & Cui, X.T. (2015). Comprehensive chronic laminar single-unit, multi-unit, and local field potential recording performance with planar single shank electrode arrays. JOURNAL OF NEUROSCIENCE METHODS, 242, 15-40.Elsevier BV. doi: 10.1016/j.jneumeth.2014.12.010.

Weaver, C.L., & Cui, X.T. (2015). Directed Neural Stem Cell Differentiation with a Functionalized Graphene Oxide Nanocomposite. ADVANCED HEALTHCARE MATERIALS, 4(9), 1408-1416.Wiley. doi: 10.1002/adhm.201500056.

Fan, J., Shao, W., Xu, G., Cui, X.T., & Luo, X. (2014). Preparation and electrochemical catalytic application of nanocrystalline cellulose doped poly(3,4-ethylenedioxythiophene) conducting polymer nanocomposites. RSC ADVANCES, 4(46), 24328-24333.Royal Society of Chemistry (RSC). doi: 10.1039/c4ra02796e.

Kozai, T.D.Y., Alba, N.A., Zhang, H., Kotov, N.A., Gaunt, R.A., & Cui, X.T. (2014). Nanostructured Coatings for Improved Charge Delivery to Neurons. In Nanotechnology and Neuroscience: Nano-electronic, Photonic and Mechanical Neuronal Interfacing. (pp. 71-134).Springer New York. doi: 10.1007/978-1-4899-8038-0_4.

Kozai, T.D.Y., Gugel, Z., Li, X., Gilgunn, P.J., Khilwani, R., Ozdoganlar, O.B., Fedder, G.K., Weber, D.J., & Cui, X.T. (2014). Chronic tissue response to carboxymethyl cellulose based dissolvable insertion needle for ultra-small neural probes. BIOMATERIALS, 35(34), 9255-9268.Elsevier BV. doi: 10.1016/j.biomaterials.2014.07.039.

Kozai, T.D.Y., Li, X., Bodily, L.M., Caparosa, E.M., Zenonos, G.A., Carlisle, D.L., Friedlander, R.M., & Cui, X.T. (2014). Effects of caspase-1 knockout on chronic neural recording quality and longevity: Insight into cellular and molecular mechanisms of the reactive tissue response. BIOMATERIALS, 35(36), 9620-9634.Elsevier BV. doi: 10.1016/j.biomaterials.2014.08.006.

Wang, W., Xu, G., Cui, X.T., Sheng, G., & Luo, X. (2014). Enhanced catalytic and dopamine sensing properties of electrochemically reduced conducting polymer nanocomposite doped with pure graphene oxide. BIOSENSORS & BIOELECTRONICS, 58, 153-156.Elsevier BV. doi: 10.1016/j.bios.2014.02.055.

Weaver, C.L., LaRosa, J.M., Luo, X., & Cui, X.T. (2014). Electrically Controlled Drug Delivery from Graphene Oxide Nanocomposite Films. ACS NANO, 8(2), 1834-1843.American Chemical Society (ACS). doi: 10.1021/nn406223e.

Weaver, C.L., Li, H., Luo, X., & Cui, X.T. (2014). A graphene oxide/conducting polymer nanocomposite for electrochemical dopamine detection: origin of improved sensitivity and specificity. JOURNAL OF MATERIALS CHEMISTRY B, 2(32), 5209-5219.Royal Society of Chemistry (RSC). doi: 10.1039/c4tb00789a.

Huang, J., Lee, I., Luo, X., Cui, X.T., & Yun, M. (2013). Shadow masking for nanomaterial-based biosensors incorporated with a microfluidic device. BIOMEDICAL MICRODEVICES, 15(3), 531-537.Springer Science and Business Media LLC. doi: 10.1007/s10544-013-9752-1.

Luo, X., Weaver, C.L., Tan, S., & Cui, X.T. (2013). Pure graphene oxide doped conducting polymer nanocomposite for bio-interfacing. JOURNAL OF MATERIALS CHEMISTRY B, 1(9), 1340-1348.Royal Society of Chemistry (RSC). doi: 10.1039/c3tb00006k.

Wang, J.Y., Liou, A.K.F., Ren, Z.H., Zhang, L., Brown, B.N., Cui, X.T., Badylak, S.F., Cai, Y.N., Guan, Y.Q., Leak, R.K., Chen, J., Ji, X., & Chen, L. (2013). Neurorestorative Effect of Urinary Bladder Matrix-Mediated Neural Stem Cell Transplantation Following Traumatic Brain Injury in Rats. CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 12(3), 413-425.Bentham Science Publishers Ltd. doi: 10.2174/1871527311312030014.

Xu, G., Li, B., Cui, X.T., Ling, L., & Luo, X. (2013). Electrodeposited conducting polymer PEDOT doped with pure carbon nanotubes for the detection of dopamine in the presence of ascorbic acid. SENSORS AND ACTUATORS B-CHEMICAL, 188, 405-410.Elsevier BV. doi: 10.1016/j.snb.2013.07.038.

Zhang, L., Zhang, F., Weng, Z., Brown, B.N., Yan, H., Ma, X.M., Vosler, P.S., Badylak, S.F., Dixon, C.E., Cui, X.T., & Chen, J. (2013). Effect of an Inductive Hydrogel Composed of Urinary Bladder Matrix Upon Functional Recovery Following Traumatic Brain Injury. TISSUE ENGINEERING PART A, 19(17-18), 1909-1918.Mary Ann Liebert Inc. doi: 10.1089/ten.tea.2012.0622.

Kolarcik, C.L., Bourbeau, D., Azemi, E., Rost, E., Zhang, L., Lagenaur, C.F., Weber, D.J., & Cui, X.T. (2012). In vivo effects of L1 coating on inflammation and neuronal health at the electrode-tissue interface in rat spinal cord and dorsal root ganglion. ACTA BIOMATERIALIA, 8(10), 3561-3575.Elsevier BV. doi: 10.1016/j.actbio.2012.06.034.

Kozai, T.D.Y., Vazquez, A.L., LWeaver, C., Kim, S.G., & Cui, X.T. (2012). In vivo two-photon microscopy reveals immediate microglial reaction to implantation of microelectrode through extension of processes. JOURNAL OF NEURAL ENGINEERING, 9(6), 066001.IOP Publishing. doi: 10.1088/1741-2560/9/6/066001.

Lee, I., Luo, X., Huang, J., Cui, X.T., & Yun, M. (2012). Detection of cardiac biomarkers using single polyaniline nanowire-based conductometric biosensors. Biosensors (Basel), 2(2), 205-220.MDPI AG. doi: 10.3390/bios2020205.

Azemi, E., Lagenaur, C.F., & Cui, X.T. (2011). The surface immobilization of the neural adhesion molecule L1 on neural probes and its effect on neuronal density and gliosis at the probe/tissue interface. BIOMATERIALS, 32(3), 681-692.Elsevier BV. doi: 10.1016/j.biomaterials.2010.09.033.

Collinger, J.L., Dicianno, B.E., Weber, D.J., Cui, X.T., Wang, W., Brienza, D.M., & Boninger, M.L. (2011). Integrating rehabilitation engineering technology with biologics. PM & R : The Journal of Injury, Function, and Rehabilitation, 3(6 Suppl 1), S148-57. doi: 10.1016/j.pmrj.2011.03.011.

Collinger, J.L., Dicianno, B.E., Weber, D.J., Cui, X.T., Wang, W., Brienza, D.M., & Boninger, M.L. (2011). Integrating Rehabilitation Engineering Technology With Biologics. PM&R, 3(6), S148-S157.Wiley. doi: 10.1016/j.pmrj.2011.03.011.

Huang, J., Luo, X., Lee, I., Hu, Y., Cui, X.T., & Yun, M. (2011). Rapid real-time electrical detection of proteins using single conducting polymer nanowire-based microfluidic aptasensor. BIOSENSORS & BIOELECTRONICS, 30(1), 306-309.Elsevier BV. doi: 10.1016/j.bios.2011.08.016.

Justin, G.A., Zhang, Y., Cui, X.T., Bradberry, C.W., Sun, M., & Sclabassi, R.J. (2011). A Metabolic Biofuel Cell: Conversion of Human Leukocyte Metabolic Activity to Electrical Currents. JOURNAL OF BIOLOGICAL ENGINEERING, 5(1), 5.Springer Science and Business Media LLC. doi: 10.1186/1754-1611-5-5.

Lee, I., Luo, X., Cui, X.T., & Yun, M. (2011). Highly sensitive single polyaniline nanowire biosensor for the detection of immunoglobulin G and myoglobin. BIOSENSORS & BIOELECTRONICS, 26(7), 3297-3302.Elsevier BV. doi: 10.1016/j.bios.2011.01.001.

Luo, X., & Cui, X.T. (2011). Electrochemical deposition of conducting polymer coatings on magnesium surfaces in ionic liquid. ACTA BIOMATERIALIA, 7(1), 441-446.Elsevier BV. doi: 10.1016/j.actbio.2010.09.006.

Luo, X., Lee, I., Huang, J., Yun, M., & Cui, X.T. (2011). Ultrasensitive protein detection using an aptamer-functionalized single polyaniline nanowire. CHEMICAL COMMUNICATIONS, 47(22), 6368-6370.Royal Society of Chemistry (RSC). doi: 10.1039/c1cc11353d.

Luo, X., Lee, I., Huang, J., Yun, M., & Cui, X.T. (2011). Ultrasensitive protein detection using an aptamer-functionalized single polyaniline nanowire. Chem Commun (Camb), 47(22), 6368-6370. doi: 10.1039/c1cc11353d.

Luo, X., Matranga, C., Tan, S., Alba, N., & Cui, X.T. (2011). Carbon nanotube nanoreservior for controlled release of anti-inflammatory dexamethasone. BIOMATERIALS, 32(26), 6316-6323.Elsevier BV. doi: 10.1016/j.biomaterials.2011.05.020.

Luo, X., Weaver, C.L., Zhou, D.D., Greenberg, R., & Cui, X.T. (2011). Highly stable carbon nanotube doped poly(3,4-ethylenedioxythiophene) for chronic neural stimulation. BIOMATERIALS, 32(24), 5551-5557.Elsevier BV. doi: 10.1016/j.biomaterials.2011.04.051.

Stauffer, W.R., Lau, P.M., Bi, G.Q., & Cui, X.T. (2011). Rapid modulation of local neural activity by controlled drug release from polymer-coated recording microelectrodes. JOURNAL OF NEURAL ENGINEERING, 8(4), 044001.IOP Publishing. doi: 10.1088/1741-2560/8/4/044001.

Alba, N.A., Sclabassi, R.J., Sun, M., & Cui, X.T. (2010). Novel Hydrogel-Based Preparation-Free EEG Electrode. IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING, 18(4), 415-423.Institute of Electrical and Electronics Engineers (IEEE). doi: 10.1109/TNSRE.2010.2048579.

Azemi, E., Gobbel, G.T., & Cui, X.T. (2010). Seeding neural progenitor cells on silicon-based neural probes Laboratory investigation. JOURNAL OF NEUROSURGERY, 113(3), 673-681.Journal of Neurosurgery Publishing Group (JNSPG). doi: 10.3171/2010.1.JNS09313.

Zhang, L., Stauffer, W.R., Jane, E.P., Sammak, P.J., & Cui, X.T. (2010). Enhanced Differentiation of Embryonic and Neural Stem Cells to Neuronal Fates on Laminin Peptides Doped Polypyrrole. MACROMOLECULAR BIOSCIENCE, 10(12), 1456-1464.Wiley. doi: 10.1002/mabi.201000176.

Luo, X., & Cui, X.T. (2009). Sponge-like nanostructured conducting polymers for electrically controlled drug release. ELECTROCHEMISTRY COMMUNICATIONS, 11(10), 1956-1959.Elsevier BV. doi: 10.1016/j.elecom.2009.08.027.

Luo, X., & Cui, X.T. (2009). Electrochemically controlled release based on nanoporous conducting polymers. ELECTROCHEMISTRY COMMUNICATIONS, 11(2), 402-404.Elsevier BV. doi: 10.1016/j.elecom.2008.11.052.

Azemi, E., Stauffer, W.R., Gostock, M.S., Lagenaur, C.F., & Cui, X.T. (2008). Surface immobilization of neural adhesion molecule L1 for improving the biocompatibility of chronic neural probes:: In vitro characterization. ACTA BIOMATERIALIA, 4(5), 1208-1217.Elsevier BV. doi: 10.1016/j.actbio.2008.02.028.

Brayfield, C.A., Marra, K.G., Leonard, J.P., Cui, X.T., & Gerlach, J.C. (2008). Excimer laser channel creation in polyethersulfone hollow fibers for compartmentalized in vitro neuronal cell culture scaffolds. ACTA BIOMATERIALIA, 4(2), 244-255.Elsevier BV. doi: 10.1016/j.actbio.2007.10.004.

Liao, W., Randall, B.A., Alba, N.A., & Cui, X.T. (2008). Conducting polymer-based impedimetric aptamer biosensor for in situ detection. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 392(5), 861-864.Springer Science and Business Media LLC. doi: 10.1007/s00216-008-2354-8.

Cui, X.T., & Zhou, D.D. (2007). Poly (3,4-ethylenedioxythiophene) for chronic neural stimulation. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 15(1), 502-508. doi: 10.1109/TNSRE.2007.909811..

Cul, X.T., & Zhou, D.D. (2007). Poly (3,4-ethylenedioxythiophene) for chronic neural stimulation. IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING, 15(4), 502-508.Institute of Electrical and Electronics Engineers (IEEE). doi: 10.1109/TNSRE.2007.909811.

Liao, W., & Cui, X.T. (2007). Reagentless aptamer based impedance biosensor for monitoring a neuro-inflammatory cytokine PDGF. BIOSENSORS & BIOELECTRONICS, 23(2), 218-224.Elsevier BV. doi: 10.1016/j.bios.2007.04.004.

Widge, A.S., Jeffries-El, M., Cui, X., Lagenaur, C.F., & Matsuoka, Y. (2007). Self-assembled monolayers of polythiophene conductive polymers improve biocompatibility and electrical impedance of neural electrodes. BIOSENSORS & BIOELECTRONICS, 22(8), 1723-1732.Elsevier BV. doi: 10.1016/j.bios.2006.08.011.

Justin, G.A., Sun, M., Zhang, Y., Cui, X.T., & Sclabassi, R. (2006). Serotonin (5-HT) released by activated white blood cells in a biological fuel cell provide a potential energy source for electricity generation. Conf Proc IEEE Eng Med Biol Soc, 2006, 4115-4118.IEEE. doi: 10.1109/IEMBS.2006.259280.

Schwartz, A.B., Cui, X.T., Weber, D.J., & Moran, D.W. (2006). Brain-controlled interfaces: Movement restoration with neural prosthetics. NEURON, 52(1), 205-220.Elsevier BV. doi: 10.1016/j.neuron.2006.09.019.

Stauffer, W.R., & Cui, X.T. (2006). Polypyrrole doped with 2 peptide sequences from laminin. BIOMATERIALS, 27(11), 2405-2413.Elsevier BV. doi: 10.1016/j.biomaterials.2005.10.024.

Tang, Z., Sclabassi, R.J., Sun, C., Hackworth, S.A., Zhao, J., Cui, X.T., & Sun, M. (2006). Transcutaneous battery recharging by volume conduction and its circuit modeling. Conf Proc IEEE Eng Med Biol Soc, 2006, 644-647. doi: 10.1109/IEMBS.2006.259702.

Wadhwa, R., Lagenaur, C.F., & Cui, X.T. (2006). Electrochemically controlled release of dexamethasone from conducting polymer polypyrrole coated electrode. JOURNAL OF CONTROLLED RELEASE, 110(3), 531-541.Elsevier BV. doi: 10.1016/j.jconrel.2005.10.027.

Xiao, Y.H., Martin, D.C., Cui, X.Y., & Shenai, M. (2006). Surface modification of neural probes with conducting polymer poly(hydroxymethylated-3,4-ethylenedioxythiophene) and its biocompatibility. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 128(2), 117-129.Springer Science and Business Media LLC. doi: 10.1385/ABAB:128:2:117.

Xiao, Y.H., Cui, X.Y., & Martin, D.C. (2004). Electrochemical polymerization and properties of PEDOT/S-EDOT on neural microelectrode arrays. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 573(1), 43-48.Elsevier BV. doi: 10.1016/j.jelechem.2004.06.024.

Xiao, Y.H., Cui, X.Y., Hancock, J.M., Bouguettaya, M.B., Reynolds, J.R., & Martin, D.C. (2004). Electrochemical polymerization of poly(hydroxymethylated-3,4-ethylenedioxythiophene) (PEDOT-MeOH) on multichannel neural probes. SENSORS AND ACTUATORS B-CHEMICAL, 99(2-3), 437-443.Elsevier BV. doi: 10.1016/j.snb.2003.12.067.

Cui, X.Y., & Martin, D.C. (2003). Fuzzy gold electrodes for lowering impedance and improving adhesion with electrodeposited conducting polymer films. SENSORS AND ACTUATORS A-PHYSICAL, 103(3), 384-394.Elsevier BV. doi: 10.1016/S0924-4247(02)00427-2.

Cui, X.Y., & Martin, D.C. (2003). Electrochemical deposition and characterization of poly(3,4-ethylenedioxythiophene) on neural microelectrode arrays. SENSORS AND ACTUATORS B-CHEMICAL, 89(1-2), 92-102.Elsevier BV. doi: 10.1016/S0925-4005(02)00448-3.

Cui, X.Y., Wiler, J., Dzaman, M., Altschuler, R.A., & Martin, D.C. (2003). In vivo studies of polypyrrole/peptide coated neural probes. BIOMATERIALS, 24(5), 777-787.Elsevier BV. doi: 10.1016/S0142-9612(02)00415-5.

Cui, X., Lee, V.A., Raphael, Y., Wiler, J.A., Hetke, J.F., Anderson, D.J., & Martin, D.C. (2001). Surface modification of neural recording electrodes with conducting polymer/biomolecule blends. J Biomed Mater Res, 56(2), 261-272. doi: 10.1002/1097-4636(200108)56:2<261::aid-jbm1094>3.0.co;2-i.

Cui, X.Y., Hetke, J.F., Wiler, J.A., Anderson, D.J., & Martin, D.C. (2001). Electrochemical deposition and characterization of conducting polymer polypyrrole/PSS on multichannel neural probes. SENSORS AND ACTUATORS A-PHYSICAL, 93(1), 8-18.Elsevier BV. doi: 10.1016/S0924-4247(01)00637-9.

Cui, X.Y., Lee, V.A., Raphael, Y., Wiler, J.A., Hetke, J.F., Anderson, D.J., & Martin, D.C. (2001). Surface modification of neural recording electrodes with conducting polymer/biomolecule blends. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 56(2), 261-272.Wiley. doi: 10.1002/1097-4636(200108)56:2<261::AID-JBM1094>3.0.CO;2-I.

Kim, H.M., Kim, Y.S., Woo, K.M., Park, S.J., Rey, C., Kim, Y., Kim, J.K., & Ko, J.S. (2001). Dissolution of poorly crystalline apatite crystals by osteoclasts determined on artificial thin-film apatite. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 56(2), 250-256.Wiley. doi: 10.1002/1097-4636(200108)56:2<250::AID-JBM1092>3.0.CO;2-S.

Cui, X., Xiao, C., Sui, S., Gong, Y., Zhang, X., & Zhao, N. (1998). Adsorption of fibrinogen on different phospholipid surfaces. Qinghua Daxue Xuebao/Journal of Tsinghua University, 38(6), 59-62.

Golabchi, A., Woeppel, K.M., & Cui, X.T. (2019). Neuronal cell adhesion molecule l1 improves quality of chronic neural recording in mouse visual cortex. In Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, 40, (p. 245).

Habeeb Rakuman, W.F., Ong, X.C., Tetikol, H.S., Khilwani, R., Cui, X.T., Ozdoganlar, O.B., Fedder, G.K., & Gilgunn, P.J. (2013). Ultra-compliant neural probes are subject to fluid forces during dissolution of polymer delivery vehicles. In Annu Int Conf IEEE Eng Med Biol Soc, 2013, (pp. 1550-1553).IEEE.United States. doi: 10.1109/EMBC.2013.6609809.

Gilgunn, P.J., Khilwani, R., Kozai, T.D.Y., Weber, D.J., Cui, X.T., Erdos, G., Ozdoganlar, O.B., & Fedder, G.K. (2012). An ultra-compliant, scalable neural probe with molded biodissolvable delivery vehicle. In 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems (MEMS), (pp. 56-59).IEEE. doi: 10.1109/memsys.2012.6170092.

Yushi Hu, Jiyong Huang, Innam Lee, Xiliang Luo, Xinyan Tracy Cui, & Minhee Yun. (2010). Single metal and conducting polymer nanowires used as chemical/bio molecular sensors. In 10th IEEE International Conference on Nanotechnology, (pp. 708-711).IEEE. doi: 10.1109/nano.2010.5697809.

Alba, N.A., Justin, G., Wadhwa, R., Sun, M., Sclabassi, R.J., & Cui, X.T. (2008). Novel hydrogel and conducting polymer-based skin surface electrode design. In Materials Research Society Symposium Proceedings, 1065, (pp. 27-32).

Liao, W., Randall, B., Alba, N., & Cui, X.T. (2008). Conducting polymer-based aptamer biosensor for in situ monitoring of cytokine. In Materials Research Society Symposium Proceedings, 1065, (pp. 43-47).

Tang, Z., Sclabassi, R.J., Sun, C., Hackworth, S.A., Zhao, J., Cui, X.T., & Sun, M. (2006). Transcutaneous Battery Recharging By Volume Conduction and its Circuit Modeling. In 2006 International Conference of the IEEE Engineering in Medicine and Biology Society, (pp. 644-647).IEEE. doi: 10.1109/iembs.2006.259702.

Cui, X.T., & Martin, D.C. (2002). Surface modification of neural recording microelectrodes with conducting polymers. In Materials Research Society Symposium - Proceedings, 698, (pp. 101-106).

Shim, J., Cui, X., Martin, D.C., & Takayama, S. (2002). Microfluidic electrochemical cell to pattern conducting polymer substrates for the study of nerve guidance. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 2, (pp. 1684-1685).

Research interests

conducting polymer
implant coatings
neural electrode tissue interface
neural engineering
on demand drug delivery