headshot of Subhadip Ghatak

Subhadip Ghatak

UCR Visiting Associate Professor
Bioengineering Department

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Welsh, J.A., Goberdhan, D.C.I., O'Driscoll, L., Buzas, E.I., Blenkiron, C., Bussolati, B., Cai, H., Di Vizio, D., Driedonks, T.A.P., Erdbrügger, U., Falcon‐Perez, J.M., Fu, Q., Hill, A.F., Lenassi, M., Lim, S.K., Mahoney, M.G., Mohanty, S., Möller, A., Nieuwland, R., Ochiya, T., Sahoo, S., Torrecilhas, A.C., Zheng, L., Zijlstra, A., Abuelreich, S., Bagabas, R., Bergese, P., Bridges, E.M., Brucale, M., Burger, D., Carney, R.P., Cocucci, E., Crescitelli, R., Hanser, E., Harris, A.L., Haughey, N.J., Hendrix, A., Ivanov, A.R., Jovanovic‐Talisman, T., Kruh‐Garcia, N.A., Ku'ulei‐Lyn Faustino, V., Kyburz, D., Lässer, C., Lennon, K.M., Lötvall, J., Maddox, A.L., Martens‐Uzunova, E.S., Mizenko, R.R., Newman, L.A., Ridolfi, A., Rohde, E., Rojalin, T., Rowland, A., Saftics, A., Sandau, U.S., Saugstad, J.A., Shekari, F., Swift, S., Ter‐Ovanesyan, D., Tosar, J.P., Useckaite, Z., Valle, F., Varga, Z., van der Pol, E., van Herwijnen, M.J.C., Wauben, M.H.M., Wehman, A.M., Williams, S., Zendrini, A., Zimmerman, A.J., Théry, C., & Witwer, K.W. (2024). Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. Journal of Extracellular Vesicles, 13(2).Wiley. doi: 10.1002/jev2.12404.

Xuan, Y., Wang, C., Ghatak, S., & Sen, C.K. (2024). Tissue Nanotransfection Silicon Chip and Related Electroporation-Based Technologies for In Vivo Tissue Reprogramming. Nanomaterials (Basel), 14(2), 217.MDPI AG. doi: 10.3390/nano14020217.

Anthony, A.J., Gautam, A.K.S., Miller, L.M., Ma, Y., Hardwick, A.G., Sharma, A., Ghatak, S., Matouschek, A., Jarrold, M.F., & Clemmer, D.E. (2023). CDMS Analysis of Intact 19S, 20S, 26S, and 30S Proteasomes: Evidence for Higher-Order 20S Assemblies at a Low pH†. Anal Chem, 95(33), 12209-12215.American Chemical Society (ACS). doi: 10.1021/acs.analchem.3c00472.

Ghatak, S., Hemann, C., Boslett, J., Singh, K., Sharma, A., Masry, M.S.E., Abouhashem, A.S., Ghosh, N., Mathew-Steiner, S.S., Roy, S., Zweier, J.L., & Sen, C.K. (2023). Bacterial Pyocyanin Inducible Keratin 6A Accelerates Closure of Epithelial Defect under Conditions of Mitochondrial Dysfunction. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 143(10), 2052-+.Elsevier BV. doi: 10.1016/j.jid.2023.03.1671.

Ghatak, S., Khanna, S., Roy, S., Thirunavukkarasu, M., Pradeep, S.R., Wulff, B.C., El Masry, M.S., Sharma, A., Palakurti, R., Ghosh, N., Xuan, Y., Wilgus, T.A., Maulik, N., Yoder, M.C., & Sen, C.K. (2023). Driving adult tissue repair via re-engagement of a pathway required for fetal healing. MOLECULAR THERAPY, 31(2), 454-470.Elsevier BV. doi: 10.1016/j.ymthe.2022.09.002.

Gnyawali, S.C., Denune, J.A., Hockman, B., Kristjánsdóttir, J.V., Ragnarsdóttir, M.S., Timsina, L.R., Ghatak, S., Lechler, K., Sen, C.K., & Roy, S. (2023). Moisture mitigation using a vented liner and a vented socket system for individuals with transfemoral amputation. Sci Rep, 13(1), 16557.Springer Science and Business Media LLC. doi: 10.1038/s41598-023-43572-2.

Gordillo, G.M., Guda, P.R., Singh, K., Biswas, A., Abouhashem, A.S., Rustagi, Y., Sen, A., Kumar, M., Das, A., Ghatak, S., Khanna, S., Sen, C.K., & Roy, S. (2023). Tissue nanotransfection causes tumor regression by its effect on nanovesicle cargo that alters microenvironmental macrophage state. Molecular Therapy, 31(5), 1402-1417.Elsevier BV. doi: 10.1016/j.ymthe.2022.11.003.

Guda, P.R., Sharma, A., Anthony, A.J., Masry, M.S.E., Couse, A.D., Ghatak, P.D., Das, A., Timsina, L., Trinidad, J.C., Roy, S., Sen, C.K., Clemmer, D.E., & Ghatak, S. (2023). Nanoscopic and functional characterization of keratinocyte-originating exosomes in the wound fluid of non-diabetic and diabetic chronic wound patients. NANO TODAY, 52, 101954.Elsevier BV. doi: 10.1016/j.nantod.2023.101954.

Pal, D., Ghatak, S., Singh, K., Abouhashem, A.S., Kumar, M., El Masry, M.S., Mohanty, S.K., Palakurti, R., Rustagi, Y., Tabasum, S., Khona, D.K., Khanna, S., Kacar, S., Srivastava, R., Bhasme, P., Verma, S.S., Hernandez, E., Sharma, A., Reese, D., Verma, P., Ghosh, N., Gorain, M., Wan, J., Liu, S., Liu, Y., Castro, N.H., Gnyawali, S.C., Lawrence, W., Moore, J., Perez, D.G., Roy, S., Yoder, M.C., & Sen, C.K. (2023). Identification of a physiologic vasculogenic fibroblast state to achieve tissue repair. NATURE COMMUNICATIONS, 14(1), 1129.Springer Science and Business Media LLC. doi: 10.1038/s41467-023-36665-z.

Palakurti, R., Biswas, N., Roy, S., Gnyawali, S.C., Sinha, M., Singh, K., Ghatak, S., Sen, C.K., & Khanna, S. (2023). Inducible miR-1224 silences cerebrovascular Serpine1 and restores blood flow to the stroke-affected site of the brain. Molecular Therapy - Nucleic Acids, 31, 276-292.Elsevier BV. doi: 10.1016/j.omtn.2022.12.019.

Srivastava, R., Singh, K., Abouhashem, A.S., Kumar, M., Kacar, S., Verma, S.S., Mohanty, S.K., Sinha, M., Ghatak, S., Xuan, Y., & Sen, C.K. (2023). Human fetal dermal fibroblast-myeloid cell diversity is characterized by dominance of pro-healing Annexin1-FPR1 signaling. ISCIENCE, 26(9), 107533.Elsevier BV. doi: 10.1016/j.isci.2023.107533.

van der Elst, L.A., Gokce, M., Coulter, J.R., Cavdar, Z.B., Koraganji, V.N., Ozturk, M., Ghatak, S., Sen, C.K., & Gumennik, A. (2023). Microstructured Electroceutical Fiber‐Device for Inhibition of Bacterial Proliferation in Wounds. Advanced Materials Interfaces, 10(3).Wiley. doi: 10.1002/admi.202201854.

Brown, B.A., Guda, P.R., Zeng, X., Anthony, A., Couse, A., Barnes, L.F., Sharon, E.M., Trinidad, J.C., Sen, C.K., Jarrold, M.F., Ghatak, S., & Clemmer, D.E. (2022). Analysis of Keratinocytic Exosomes from Diabetic and Nondiabetic Mice by Charge Detection Mass Spectrometry. Anal Chem, 94(25), 8909-8918.American Chemical Society (ACS). doi: 10.1021/acs.analchem.2c00453.

Clark, A., Ghatak, S., Guda, P.R., El Masry, M.S., Xuan, Y., Sato, A.Y., Bellido, T., & Sen, C.K. (2022). Myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss. NPJ REGENERATIVE MEDICINE, 7(1), 63.Springer Science and Business Media LLC. doi: 10.1038/s41536-022-00259-y.

Li, Z., Xuan, Y., Ghatak, S., Guda, P.R., Roy, S., & Sen, C.K. (2022). Modeling the gene delivery process of the needle array-based tissue nanotransfection. Nano Research, 15(4), 3409-3421.Springer Science and Business Media LLC. doi: 10.1007/s12274-021-3947-1.

Santra, A., Bishnu, D., Santra, S., Ghatak, S., Mukherjee, P.S., Dhali, G.K., & Chowdhury, A. (2022). Arsenic-Induced Injury of Mouse Hepatocytes through Lysosome and Mitochondria: An In Vitro Study. International Journal of Hepatology, 2022, 1-12.Hindawi Limited. doi: 10.1155/2022/1546297.

Singh, K., Rustagi, Y., Abouhashem, A.S., Tabasum, S., Verma, P., Hernandez, E., Pal, D., Khona, D.K., Mohanty, S.K., Kumar, M., Srivastava, R., Guda, P.R., Verma, S.S., Mahajan, S., Killian, J.A., Walker, L.A., Ghatak, S., Mathew-Steiner, S.S., Wanczyk, K.E., Liu, S., Wan, J., Yan, P., Bundschuh, R., Khanna, S., Gordillo, G.M., Murphy, M.P., Roy, S., & Sen, C.K. (2022). Genome-wide DNA hypermethylation opposes healing in patients with chronic wounds by impairing epithelial-mesenchymal transition. JOURNAL OF CLINICAL INVESTIGATION, 132(17).American Society for Clinical Investigation. doi: 10.1172/JCI157279.

Khona, D.K., Roy, S., Ghatak, S., Huang, K., Jagdale, G., Baker, L.A., & Sen, C.K. (2021). Ketoconazole resistant Candida albicans is sensitive to a wireless electroceutical wound care dressing. Bioelectrochemistry, 142, 107921.Elsevier BV. doi: 10.1016/j.bioelechem.2021.107921.

Xuan, Y., Ghatak, S., Clark, A., Li, Z., Khanna, S., Pak, D., Agarwal, M., Roy, S., Duda, P., & Sen, C.K. (2021). Fabrication and use of silicon hollow-needle arrays to achieve tissue nanotransfection in mouse tissue in vivo. Nature Protocols, 16(12), 5707-5738.Springer Science and Business Media LLC. doi: 10.1038/s41596-021-00631-0.

Deng, B., Ghatak, S., Sarkar, S., Singh, K., Das Ghatak, P., Mathew-Steiner, S.S., Roy, S., Khanna, S., Wozniak, D.J., McComb, D.W., & Sen, C.K. (2020). Novel Bacterial Diversity and Fragmented eDNA Identified in Hyperbiofilm-Forming Pseudomonas aeruginosa Rugose Small Colony Variant. iScience, 23(2), 100827.Elsevier BV. doi: 10.1016/j.isci.2020.100827.

Gnyawali, S.C., Sinha, M., El Masry, M.S., Wulff, B., Ghatak, S., Soto-Gonzalez, F., Wilgus, T.A., Roy, S., & Sen, C.K. (2020). High resolution ultrasound imaging for repeated measure of wound tissue morphometry, biomechanics and hemodynamics under fetal, adult and diabetic conditions. PLOS ONE, 15(11), e0241831.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0241831.

Gupta, S., Ghatak, S., Hery, T., Khanna, S., El Masry, M., Sundaresan, V.B., & Sen, C.K. (2020). Ad hoc hybrid synaptic junctions to detect nerve stimulation and its application to detect onset of diabetic polyneuropathy. BIOSENSORS & BIOELECTRONICS, 169, 112618.Elsevier BV. doi: 10.1016/j.bios.2020.112618.

Roy, S., Santra, S., Das, A., Dixith, S., Sinha, M., Ghatak, S., Ghosh, N., Banerjee, P., Khanna, S., Mathew-Steiner, S., Ghatak, P.D., Blackstone, B.N., Powell, H.M., Bergdall, V.K., Wozniak, D.J., & Sen, C.K. (2020). Staphylococcus aureus Biofilm Infection Compromises Wound Healing by Causing Deficiencies in Granulation Tissue Collagen. Annals of Surgery, 271(6), 1174-1185.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/sla.0000000000003053.

Roy, S., Sen, C.K., Ghatak, S., Higuita-Castro, N., Palakurti, R., Nalluri, N., Clark, A., Stewart, R., Gallego-Perez, D., Prater, D.N., & Khanna, S. (2020). Neurogenic tissue nanotransfection in the management of cutaneous diabetic polyneuropathy. Nanomedicine: Nanotechnology, Biology and Medicine, 28, 102220.Elsevier BV. doi: 10.1016/j.nano.2020.102220.

Zhou, X., Brown, B.A., Siegel, A.P., El Masry, M.S., Zeng, X., Song, W., Das, A., Khandelwal, P., Clark, A., Singh, K., Guda, P.R., Gorain, M., Timsina, L., Xuan, Y., Jacobson, S.C., Novotny, M.V., Roy, S., Agarwal, M., Lee, R.J., Sen, C.K., Clemmer, D.E., & Ghatak, S. (2020). Exosome-Mediated Crosstalk between Keratinocytes and Macrophages in Cutaneous Wound Healing. ACS NANO, 14(10), 12732-12748.American Chemical Society (ACS). doi: 10.1021/acsnano.0c03064.

Das, A., El Masry, M.S., Gnyawali, S.C., Ghatak, S., Singh, K., Stewart, R., Lewis, M., Saha, A., Gordillo, G., & Khanna, S. (2019). Skin Transcriptome of Middle-Aged Women Supplemented With Natural Herbo-mineral Shilajit Shows Induction of Microvascular and Extracellular Matrix Mechanisms. JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, 38(6), 526-536.Informa UK Limited. doi: 10.1080/07315724.2018.1564088.

Zgheib, C., Hilton, S.A., Dewberry, L.C., Hodges, M.M., Ghatak, S., Xu, J., Singh, S., Roy, S., Sen, C.K., Seal, S., & Liechty, K.W. (2019). Use of Cerium Oxide Nanoparticles Conjugated with MicroRNA-146a to Correct the Diabetic Wound Healing Impairment. Journal of the American College of Surgeons, 228(1), 107-115.Ovid Technologies (Wolters Kluwer Health). doi: 10.1016/j.jamcollsurg.2018.09.017.

Li, J., Ghatak, S., El Masry, M.S., Das, A., Liu, Y., Roy, S., Lee, R.J., & Sen, C.K. (2018). Topical Lyophilized Targeted Lipid Nanoparticles in the Restoration of Skin Barrier Function following Burn Wound. MOLECULAR THERAPY, 26(9), 2178-2188.Elsevier BV. doi: 10.1016/j.ymthe.2018.04.021.

Ahmed, N.S., Ghatak, S., El Masry, M.S., Gnyawali, S.C., Roy, S., Amer, M., Everts, H., Sen, C.K., & Khanna, S. (2017). Epidermal E-Cadherin Dependent β-Catenin Pathway Is Phytochemical Inducible and Accelerates Anagen Hair Cycling. MOLECULAR THERAPY, 25(11), 2502-2512.Elsevier BV. doi: 10.1016/j.ymthe.2017.07.010.

Gallego-Perez, D., Pal, D., Ghatak, S., Malkoc, V., Higuita-Castro, N., Gnyawali, S., Chang, L., Liao, W.C., Shi, J., Sinha, M., Singh, K., Steen, E., Sunyecz, A., Stewart, R., Moore, J., Ziebro, T., Northcutt, R.G., Homsy, M., Bertani, P., Lu, W., Roy, S., Khanna, S., Rink, C., Sundaresan, V.B., Otero, J.J., Lee, L.J., & Sen, C.K. (2017). Topical tissue nano-transfection mediates non-viral stroma reprogramming and rescue. Nature Nanotechnology, 12(10), 974-979.Springer Science and Business Media LLC. doi: 10.1038/nnano.2017.134.

Singh, K., Pal, D., Sinha, M., Ghatak, S., Gnyawali, S.C., Khanna, S., Roy, S., & Sen, C.K. (2017). Epigenetic Modification of MicroRNA-200b Contributes to Diabetic Vasculopathy. Molecular Therapy, 25(12), 2689-2704.Elsevier BV. doi: 10.1016/j.ymthe.2017.09.009.

Das, A., Ghatak, S., Sinha, M., Chaffee, S., Ahmed, N.S., Parinandi, N.L., Wohleb, E.S., Sheridan, J.F., Sen, C.K., & Roy, S. (2016). Correction of MFG-E8 Resolves Inflammation and Promotes Cutaneous Wound Healing in Diabetes. The Journal of Immunology, 196(12), 5089-5100.The American Association of Immunologists. doi: 10.4049/jimmunol.1502270.

Gallego-Perez, D., Otero, J.J., Czeisler, C., Ma, J., Ortiz, C., Gygli, P., Catacutan, F.P., Gokozan, H.N., Cowgill, A., Sherwood, T., Ghatak, S., Malkoc, V., Zhao, X., Liao, W.C., Gnyawali, S., Wang, X., Adler, A.F., Leong, K., Wulff, B., Wilgus, T.A., Askwith, C., Khanna, S., Rink, C., Sen, C.K., & Lee, L.J. (2016). Deterministic transfection drives efficient nonviral reprogramming and uncovers reprogramming barriers. Nanomedicine: Nanotechnology, Biology and Medicine, 12(2), 399-409.Elsevier BV. doi: 10.1016/j.nano.2015.11.015.

Ghatak, S., Li, J., Chan, Y.C., Gnyawali, S.C., Steen, E., Yung, B.C., Khanna, S., Roy, S., Lee, R.J., & Sen, C.K. (2016). AntihypoxamiR functionalized gramicidin lipid nanoparticles rescue against ischemic memory improving cutaneous wound healing. Nanomedicine: Nanotechnology, Biology and Medicine, 12(7), 1827-1831.Elsevier BV. doi: 10.1016/j.nano.2016.03.004.

Sen, C.K., Ghatak, S., Gnyawali, S.C., Roy, S., & Gordillo, G.M. (2016). Cutaneous Imaging Technologies in Acute Burn and Chronic Wound Care. Plastic & Reconstructive Surgery, 138(3S), 119S-128S.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/prs.0000000000002654.

Ghatak, S., Chan, Y.C., Khanna, S., Banerjee, J., Weist, J., Roy, S., & Sen, C.K. (2015). Barrier Function of the Repaired Skin Is Disrupted Following Arrest of Dicer in Keratinocytes. Molecular Therapy, 23(7), 1201-1210.Elsevier BV. doi: 10.1038/mt.2015.65.

Sen, C.K., & Ghatak, S. (2015). miRNA Control of Tissue Repair and Regeneration. The American Journal of Pathology, 185(10), 2629-2640.Elsevier BV. doi: 10.1016/j.ajpath.2015.04.001.

Sinha, M., Ghatak, S., Roy, S., & Sen, C.K. (2015). microRNA–200b as a Switch for Inducible Adult Angiogenesis. Antioxidants & Redox Signaling, 22(14), 1257-1272.Mary Ann Liebert Inc. doi: 10.1089/ars.2014.6065.

Ghatak, S., Biswas, A., Dhali, G.K., Chowdhury, A., Boyer, J.L., & Santra, A. (2011). Oxidative stress and hepatic stellate cell activation are key events in arsenic induced liver fibrosis in mice. Toxicology and Applied Pharmacology, 251(1), 59-69.Elsevier BV. doi: 10.1016/j.taap.2010.11.016.

Santra, A., Chowdhury, A., Ghatak, S., Biswas, A., & Dhali, G.K. (2007). Arsenic induces apoptosis in mouse liver is mitochondria dependent and is abrogated by N-acetylcysteine. Toxicology and Applied Pharmacology, 220(2), 146-155.Elsevier BV. doi: 10.1016/j.taap.2006.12.029.

Chowdhury, A., Santra, A., Bhattacharjee, K., Ghatak, S., Saha, D.R., & Dhali, G.K. (2006). Mitochondrial oxidative stress and permeability transition in Isoniazid and Rifampicin induced liver injury in mice. Journal of Hepatology, 45(1), 117-126.Elsevier BV. doi: 10.1016/j.jhep.2006.01.027.

Samanta, A.K., Dhargupta, K.K., & Ghatak, S. (2001). Journal of Materials Science Letters, 20(22), 2077-2080.Springer Science and Business Media LLC. doi: 10.1023/a:1013566729914.

Ghatak, S., & Ho, S.M. (1996). Age-Related Changes in the Activities of Antioxidant Enzymes and Lipid Peroxidation Status in Ventral and Dorsolateral Prostate Lobes of Noble Rats. Biochemical and Biophysical Research Communications, 222(2), 362-367.Elsevier BV. doi: 10.1006/bbrc.1996.0749.

Ghatak, S., Khona, D.K., Sen, A., Huang, K., Jagdale, G., Singh, K., Gopalakrishnan, V., Cornetta, K.G., Roy, S., Khanna, S., Baker, L.A., & Sen, C.K. Electroceutical fabric lowers zeta potential and eradicates coronavirus infectivity upon contact. Scientific Reports, 11(1).Springer Science and Business Media LLC. doi: 10.1038/s41598-021-00910-6.

Gnyawali, S.C., Blum, K., Pal, D., Ghatak, S., Khanna, S., Roy, S., & Sen, C.K. Retooling Laser Speckle Contrast Analysis Algorithm to Enhance Non-Invasive High Resolution Laser Speckle Functional Imaging of Cutaneous Microcirculation. Scientific Reports, 7(1).Springer Science and Business Media LLC. doi: 10.1038/srep41048.

Sharma, A., Yadav, A., Nandy, A., & Ghatak, S. Insight into the Functional Dynamics and Challenges of Exosomes in Pharmaceutical Innovation and Precision Medicine. Pharmaceutics, 16(6), 709.MDPI AG. doi: 10.3390/pharmaceutics16060709.

Sinha, M., Sen, C.K., Singh, K., Das, A., Ghatak, S., Rhea, B., Blackstone, B., Powell, H.M., Khanna, S., & Roy, S. Direct conversion of injury-site myeloid cells to fibroblast-like cells of granulation tissue. Nature Communications, 9(1).Springer Science and Business Media LLC. doi: 10.1038/s41467-018-03208-w.

El Masry, M.S., Ghosh, N., Smith, J., Ghatak, S., Roy, S., & Sen, C.K. (2021). Aurine Tricarboxylic Acid (ATA) Disrupts DNase-resistant Wound Biofilm Formed By Persister Clinical Isolate Bacteria. In WOUND REPAIR AND REGENERATION, 29(3), (pp. A47-A48).

Ghatak, S., Zhou, X., Bhattacharya, S., El Masry, M.S., Das, A., Roy, S., Lee, R.J., & Sen, C.K. (2019). SIRNA FUNCTIONALIZED TARGETED LIPID NANOPARTICLES TO MANIPULATE EXOSOMAL MICRORNA PACKAGING IN KERATINOCYTES. In WOUND REPAIR AND REGENERATION, 27(3), (pp. A31-A32).

Biswas, A., Ghatak, S., El Masry, M., Khanna, S., Roy, S., & Sen, C.K. (2018). Epithelial Hypoxamir Mir-210 Directly Contributes to Ischemic Skin Injury. In WOUND REPAIR AND REGENERATION, 26(1), (p. A15).

Ghatak, S., Li, J., El Masry, M.S., Das, A., Liu, Y., Roy, S., Lee, R.J., & Sen, C.K. (2018). Design and Test of Targeted Lipid-nanoparticles in Burn Wound Care. In WOUND REPAIR AND REGENERATION, 26(1), (p. A8).

ElMasry, M.S., Ghatak, S., Ahmed, N.S., Gnyawali, S.C., Roy, S., Sen, C.K., & Khanna, S. (2017). ENRICHMENT OF SKIN STEM CELL POOL BY INDUCIBLE HAIR FOLLICULOGENESIS. In WOUND REPAIR AND REGENERATION, 25(4), (p. A21).

Steiner, S.S., Ghatak, S., Rhea, B., El Masry, M., Schwab, E., Gnyawali, S., Roy, S., Leung, K., & Sen, C.K. (2017). PRECLINICAL PORCINE MAXILLOFACIAL MODEL TO STUDY LONG-TERM CONSEQUENCES OF BURN TRAUMA. In WOUND REPAIR AND REGENERATION, 25(4), (p. A26).