Pravat Mandal

Dr. Mandal is a Research Professor at the Neurological Surgery and Raiology department in the University of Pittsburgh School of Medicine. He completed his graduate studies (Ph.D) at the Indian Institute of Technology, Madras and his postdoctoral training at the University of California, Davis. Dr. Mandal participated in a clinical residency program at the University of Pittsburgh Alzheimer’s disease (AD) research centre. He was a Professor and Director-in-Charge in the National Brain Research Centre (Govt. of India). His work focuses on identifying oxidative stress mapping and quantification using Magnetic Resonance Spectroscopy (MRS). 

  • Ph.D, Indian Institute of Technology Madras

  • Jindal, K., Sharma, S., & Mandal, P.K. (2026). NINS_QC: A Data Quality Checker in Neuroimaging. ACS Chem Neurosci, 17(7), 1229-1232.American Chemical Society (ACS). doi: 10.1021/acschemneuro.6c00178.
  • Mandal, P.K., Perry, G., Maroon, J.C., Corby, P., Patira, R., & Lopez, O.L. (2026). Bypassing the bottleneck: Gamma-glutamylcysteine supplementation for brain glutathione enrichment in Alzheimer's disease. J Alzheimers Dis, 113(4), 1626-1633.SAGE Publications. doi: 10.1177/13872877261474009.
  • Mandal, P.K., Arora, Y., Samkaria, A., Maroon, J.C., Fodale, V., Mehta, Y., & Chang, Y.F. (2025). Oxidative Stress Monitoring Platform: A Longitudinal In vitro Multinuclear (1H/19F) MR Spectroscopic Study. Cell Biochem Biophys, 83(2), 2281-2288.Springer Nature. doi: 10.1007/s12013-024-01640-y.
  • Mandal, P.K., Maroon, J.C., Guha Roy, R., Patira, R., Gogniat, M.A., & Sindhu, B. (2025). The Missing Link in Antiamyloid Therapy. ACS Chem Neurosci, 16(3), 276-280.American Chemical Society (ACS). doi: 10.1021/acschemneuro.4c00825.
  • Arora, Y., Samkaria, A., Maroon, J.C., & Mandal, P.K. (2024). Longitudinal Monitoring of Glutathione Stability in Different Microenvironments. Neurochem Res, 50(1), 9.Springer Nature. doi: 10.1007/s11064-024-04265-y.
  • Mandal, P.K. (2024). Pro-Oxidants and Antioxidants Imbalance in Alzheimer's Disease. In Mandal, P.K. (Ed.). J Alzheimers Dis, 99(s1), S1-S4.SAGE Publications. doi: 10.3233/JAD-240217.
  • Mandal, P.K., Maroon, J.C., Samkaria, A., Arora, Y., Sharma, S., & Pandey, A. (2024). Iron Chelators and Alzheimer's Disease Clinical Trials. J Alzheimers Dis, 100(s1), S243-S249.SAGE Publications. doi: 10.3233/JAD-240605.
  • Mandal, P.K., Dwivedi, D., Joon, S., Goel, A., Ahasan, Z., Maroon, J.C., Singh, P., Saxena, R., & Roy, R.G. (2023). Quantitation of Brain and Blood Glutathione and Iron in Healthy Age Groups Using Biophysical and In Vivo MR Spectroscopy: Potential Clinical Application. ACS Chem Neurosci, 14(12), 2375-2384.American Chemical Society (ACS). doi: 10.1021/acschemneuro.3c00168.
  • Mandal, P.K., Guha Roy, R., & Kalyani, A. (2023). Distribution Pattern of Closed and Extended Forms of Glutathione in the Human Brain: MR Spectroscopic Study. ACS Chem Neurosci, 14(2), 270-276.American Chemical Society (ACS). doi: 10.1021/acschemneuro.2c00573.
  • Mandal, P.K., Jindal, K., Maroon, J.C., Chhikara, R., Samkaria, A., Joshi, M., Roy, S., & Arora, Y. (2023). Brain Imaging Databases. ACS Chem Neurosci, 14(11), 1930-1934.American Chemical Society (ACS). doi: 10.1021/acschemneuro.3c00265.
  • Mandal, P.K., Jindal, K., Roy, S., Arora, Y., Sharma, S., Joon, S., Goel, A., Ahasan, Z., Maroon, J.C., Singh, K., Sandal, K., Tripathi, M., Sharma, P., Samkaria, A., Gaur, S., & Shandilya, S. (2023). SWADESH: a multimodal multi-disease brain imaging and neuropsychological database and data analytics platform. Front Neurol, 14, 1258116.Frontiers. doi: 10.3389/fneur.2023.1258116.
  • Mandal, P.K., Maroon, J.C., Garg, A., Arora, N.K., Bansal, R., Kaushik, A., Samkaria, A., Kumaran, G., & Arora, Y. (2023). Blood Biomarkers in Alzheimer's Disease. ACS Chem Neurosci, 14(22), 3975-3978.American Chemical Society (ACS). doi: 10.1021/acschemneuro.3c00641.
  • Roy, R.G., Mandal, P.K., & Maroon, J.C. (2023). Oxidative Stress Occurs Prior to Amyloid Aβ Plaque Formation and Tau Phosphorylation in Alzheimer's Disease: Role of Glutathione and Metal Ions. ACS Chem Neurosci, 14(17), 2944-2954.American Chemical Society (ACS). doi: 10.1021/acschemneuro.3c00486.
  • Sharma, S., & Mandal, P.K. (2023). A Comprehensive Report on Machine Learning-based Early Detection of Alzheimer's Disease using Multi-modal Neuroimaging Data. ACM COMPUTING SURVEYS, 55(2).Association for Computing Machinery (ACM). doi: 10.1145/3492865.
  • Shukla, D., Goel, A., Mandal, P.K., Joon, S., Punjabi, K., Arora, Y., Kumar, R., Mehta, V.S., Singh, P., Maroon, J.C., Bansal, R., Sandal, K., Roy, R.G., Samkaria, A., Sharma, S., Sandhilya, S., Gaur, S., Parvathi, S., & Joshi, M. (2023). Glutathione Depletion and Concomitant Elevation of Susceptibility in Patients with Parkinson's Disease: State-of-the-Art MR Spectroscopy and Neuropsychological Study. ACS Chem Neurosci, 14(24), 4383-4394.American Chemical Society (ACS). doi: 10.1021/acschemneuro.3c00717.
  • Craven, A.R., Bhattacharyya, P.K., Clarke, W.T., Dydak, U., Edden, R.A.E., Ersland, L., Mandal, P.K., Mikkelsen, M., Murdoch, J.B., Near, J., Rideaux, R., Shukla, D., Wang, M., Wilson, M., Zöllner, H.J., Hugdahl, K., & Oeltzschner, G. (2022). Comparison of seven modelling algorithms for γ-aminobutyric acid-edited proton magnetic resonance spectroscopy. NMR Biomed, 35(7), e4702.Wiley. doi: 10.1002/nbm.4702.
  • Handa, P., Samkaria, A., Sharma, S., Arora, Y., & Mandal, P.K. (2022). Comprehensive Account of Sodium Imaging and Spectroscopy for Brain Research. ACS Chem Neurosci, 13(7), 859-875.American Chemical Society (ACS). doi: 10.1021/acschemneuro.2c00027.
  • Mandal, P.K., Dwivedi, D., Shukla, D., Samkaria, A., Roy, R.G., Arora, Y., & Jindal, K. (2022). Interplay Between Hippocampal Glutathione Depletion and pH Increment in Alzheimer's Disease. J Alzheimers Dis, 88(1), 1-6.SAGE Publications. doi: 10.3233/JAD-215729.
  • Mandal, P.K., Gaur, S., Roy, R.G., Samkaria, A., Ingole, R., & Goel, A. (2022). Schizophrenia, Bipolar and Major Depressive Disorders: Overview of Clinical Features, Neurotransmitter Alterations, Pharmacological Interventions, and Impact of Oxidative Stress in the Disease Process. ACS Chem Neurosci, 13(19), 2784-2802.American Chemical Society (ACS). doi: 10.1021/acschemneuro.2c00420.
  • Mandal, P.K., Goel, A., Bush, A.I., Punjabi, K., Joon, S., Mishra, R., Tripathi, M., Garg, A., Kumar, N.K., Sharma, P., Shukla, D., Ayton, S.J., Fazlollahi, A., Maroon, J.C., Dwivedi, D., Samkaria, A., Sandal, K., Megha, K., & Shandilya, S. (2022). Hippocampal glutathione depletion with enhanced iron level in patients with mild cognitive impairment and Alzheimer's disease compared with healthy elderly participants. Brain Commun, 4(5), fcac215.Oxford University Press (OUP). doi: 10.1093/braincomms/fcac215.
  • Mandal, P.K., Guha Roy, R., Samkaria, A., Maroon, J.C., & Arora, Y. (2022). In Vivo 13C Magnetic Resonance Spectroscopy for Assessing Brain Biochemistry in Health and Disease. Neurochem Res, 47(5), 1183-1201.Springer Nature. doi: 10.1007/s11064-022-03538-8.
  • Mandal, P.K., Roy, R.G., & Samkaria, A. (2022). Oxidative Stress: Glutathione and Its Potential to Protect Methionine-35 of Aβ Peptide from Oxidation. ACS Omega, 7(31), 27052-27061.American Chemical Society (ACS). doi: 10.1021/acsomega.2c02760.
  • Prasad, K., Dwivedi, S.N., Kant, S., Vibha, D., Pandit, A.K., Karthikeyan, G., Tripathi, M., Srivastava, A.K., Nehra, A., Vivekanandhan, S., Garg, A., Chutani, A.M., Verma, V., Kumar, S., Kumar, A., Gulati, K., Gulati, A., Makharia, G., Seth, T., Dhingra, K., Mandal, P.K., Mishra, N.K., Ikram, A., & Tiemeier, H. (2022). Cohort Profile: The LoCARPoN-a population-based prospective cohort study in middle-aged and older adults in India. Int J Epidemiol, 51(1), 29-30m.Oxford University Press (OUP). doi: 10.1093/ije/dyab078.
  • Goel, A., Roy, S., Punjabi, K., Mishra, R., Tripathi, M., Shukla, D., & Mandal, P.K. (2021). PRATEEK: Integration of Multimodal Neuroimaging Data to Facilitate Advanced Brain Research. J Alzheimers Dis, 83(1), 305-317.SAGE Publications. doi: 10.3233/JAD-210440.
  • Mandal, P.K., Samkaria, A., & Maroon, J.C. (2021). AD Hypotheses and Suggested Clinical Trials. ACS Chem Neurosci, 12(21), 3968-3971.American Chemical Society (ACS). doi: 10.1021/acschemneuro.1c00627.
  • Samkaria, A., & Mandal, P.K. (2021). Brain Imaging in COVID-19. ACS Chem Neurosci, 12(16), 2953-2955.American Chemical Society (ACS). doi: 10.1021/acschemneuro.1c00467.
  • Samkaria, A., Punjabi, K., Sharma, S., Joon, S., Sandal, K., Dasgupta, T., Sharma, P., & Mandal, P.K. (2021). Brain Stress Mapping in COVID-19 Survivors Using MR Spectroscopy: New Avenue of Mental Health Status Monitoring$. J Alzheimers Dis, 83(2), 523-530.SAGE Publications. doi: 10.3233/JAD-210287.
  • Shukla, D., Mandal, P.K., Mishra, R., Punjabi, K., Dwivedi, D., Tripathi, M., & Badhautia, V. (2021). Hippocampal Glutathione Depletion and pH Increment in Alzheimer's Disease: An in vivo MRS Study. J Alzheimers Dis, 84(3), 1139-1152.SAGE Publications. doi: 10.3233/JAD-215032.
  • Dwivedi, D., Megha, K., Mishra, R., & Mandal, P.K. (2020). Glutathione in Brain: Overview of Its Conformations, Functions, Biochemical Characteristics, Quantitation and Potential Therapeutic Role in Brain Disorders. Neurochem Res, 45(7), 1461-1480.Springer Nature. doi: 10.1007/s11064-020-03030-1.
  • Mandal, P.K., & Shukla, D. (2020). KALPANA: Advanced Spectroscopic Signal Processing Platform for Improved Accuracy to Aid in Early Diagnosis of Brain Disorders in Clinical Setting. J Alzheimers Dis, 75(2), 397-402.SAGE Publications. doi: 10.3233/JAD-191351.
  • Mandal, P.K., Sandal, K., Shukla, D., Tripathi, M., Singh, K., & Roy, S. (2020). ANSH: Multimodal Neuroimaging Database Including MR Spectroscopic Data From Each Continent to Advance Alzheimer's Disease Research. Front Neuroinform, 14, 571039.Frontiers. doi: 10.3389/fninf.2020.571039.
  • Pai, P.P., Mandal, P.K., Punjabi, K., Shukla, D., Goel, A., Joon, S., Roy, S., Sandal, K., Mishra, R., & Lahoti, R. (2020). BRAHMA: Population specific T1, T2, and FLAIR weighted brain templates and their impact in structural and functional imaging studies. Magn Reson Imaging, 70, 5-21.Elsevier. doi: 10.1016/j.mri.2019.12.009.
  • Shukla, D., Mandal, P.K., Tripathi, M., Vishwakarma, G., Mishra, R., & Sandal, K. (2020). Quantitation of in vivo brain glutathione conformers in cingulate cortex among age-matched control, MCI, and AD patients using MEGA-PRESS. Hum Brain Mapp, 41(1), 194-217.Wiley. doi: 10.1002/hbm.24799.
  • Mandal, P.K., & Ersland, L. (2019). Editorial: Predictive Imagable Biomarkers for Neurodegenerative and Neurodevelopmental Diseases. Front Neurol, 10, 583.Frontiers. doi: 10.3389/fneur.2019.00583.
  • Mandal, P.K., Shukla, D., Tripathi, M., & Ersland, L. (2019). Cognitive Improvement with Glutathione Supplement in Alzheimer's Disease: A Way Forward. J Alzheimers Dis, 68(2), 531-535.SAGE Publications. doi: 10.3233/JAD-181054.
  • Sharma, A., Shukla, D., Goel, T., & Mandal, P.K. (2019). BHARAT: An Integrated Big Data Analytic Model for Early Diagnostic Biomarker of Alzheimer's Disease. Front Neurol, 10, 9.Frontiers. doi: 10.3389/fneur.2019.00009.
  • Mandal, P.K., & Shukla, D. (2018). Brain Metabolic, Structural, and Behavioral Pattern Learning for Early Predictive Diagnosis of Alzheimer's Disease. J Alzheimers Dis, 63(3), 935-939.SAGE Publications. doi: 10.3233/JAD-180063.
  • Mandal, P.K., & Shukla, D. (2018). Brain Metabolic, Structural, and Behavioral Pattern Learning for Early Predictive Diagnosis of Alzheimer's Disease. J Alzheimers Dis, 64(2), 669-670.SAGE Publications. doi: 10.3233/JAD-189005.
  • Mandal, P.K., Banerjee, A., Tripathi, M., & Sharma, A. (2018). A Comprehensive Review of Magnetoencephalography (MEG) Studies for Brain Functionality in Healthy Aging and Alzheimer's Disease (AD). Front Comput Neurosci, 12, 60.Frontiers. doi: 10.3389/fncom.2018.00060.
  • Shukla, D., Mandal, P.K., Ersland, L., Grüner, E.R., Tripathi, M., Raghunathan, P., Sharma, A., Chaithya, G.R., Punjabi, K., & Splaine, C. (2018). A Multi-Center Study on Human Brain Glutathione Conformation using Magnetic Resonance Spectroscopy. J Alzheimers Dis, 66(2), 517-532.SAGE Publications. doi: 10.3233/JAD-180648.
  • Mandal, P.K., Shukla, D., Govind, V., Boulard, Y., & Ersland, L. (2017). Glutathione Conformations and Its Implications for in vivo Magnetic Resonance Spectroscopy. J Alzheimers Dis, 59(2), 537-541.SAGE Publications. doi: 10.3233/JAD-170350.
  • Prashanth, R., Roy, S.D., Mandal, P.K., & Ghosh, S. (2017). High-Accuracy Classification of Parkinson's Disease Through Shape Analysis and Surface Fitting in 123I-Ioflupane SPECT Imaging. IEEE J Biomed Health Inform, 21(3), 794-802.Institute of Electrical and Electronics Engineers (IEEE). doi: 10.1109/JBHI.2016.2547901.
  • Duggirala, S.X., Saharan, S., Raghunathan, P., & Mandal, P.K. (2016). Stimulus-dependent modulation of working memory for identity monitoring: A functional MRI study. Brain Cogn, 102, 55-64.Elsevier. doi: 10.1016/j.bandc.2015.12.006.
  • Grewal, M., Dabas, A., Saharan, S., Barker, P.B., Edden, R.A.E., & Mandal, P.K. (2016). GABA quantitation using MEGA-PRESS: Regional and hemispheric differences. J Magn Reson Imaging, 44(6), 1619-1623.Wiley. doi: 10.1002/jmri.25324.
  • Prashanth, R., Dutta Roy, S., Mandal, P.K., & Ghosh, S. (2016). High-Accuracy Detection of Early Parkinson's Disease through Multimodal Features and Machine Learning. Int J Med Inform, 90, 13-21.Elsevier. doi: 10.1016/j.ijmedinf.2016.03.001.
  • Mandal, P.K., Saharan, S., Khan, S.A., & James, M. (2015). Apps for Dementia Screening: A Cost-effective and Portable Solution. J Alzheimers Dis, 47(4), 869-872.SAGE Publications. doi: 10.3233/JAD-150255.
  • Mandal, P.K., Saharan, S., Tripathi, M., & Murari, G. (2015). Brain glutathione levels--a novel biomarker for mild cognitive impairment and Alzheimer's disease. Biol Psychiatry, 78(10), 702-710.Elsevier. doi: 10.1016/j.biopsych.2015.04.005.
  • Joshi, J., Saharan, S., & Mandal, P.K. (2014). BOLDSync: a MATLAB-based toolbox for synchronized stimulus presentation in functional MRI. J Neurosci Methods, 223, 123-132.Elsevier. doi: 10.1016/j.jneumeth.2013.12.002.
  • Mandal, P.K. (2014). Brain metabolic mapping with MRS: A potent noninvasive tool for clinical diagnosis of brain disorders. AJNR Am J Neuroradiol, 35(6 Suppl), S1-S3.American Society of Neuroradiology (ASNR). doi: 10.3174/ajnr.A4020.
  • Mandal, P.K., Ritchie, K., & Fodale, V. (2014). Anesthetics and its impact on the brain and Alzheimer's disease. J Alzheimers Dis, 39(2), 223-225.SAGE Publications. doi: 10.3233/JAD-131487.
  • Prashanth, R., Roy, S.D., Mandal, P.K., & Ghosh, S. (2014). Automatic classification and prediction models for early Parkinson's disease diagnosis from SPECT imaging. EXPERT SYSTEMS WITH APPLICATIONS, 41(7), 3333-3342.Elsevier. doi: 10.1016/j.eswa.2013.11.031.
  • Saharan, S., & Mandal, P.K. (2014). The emerging role of glutathione in Alzheimer's disease. J Alzheimers Dis, 40(3), 519-529.SAGE Publications. doi: 10.3233/JAD-132483.
  • Mandal, P.K. (2012). Predictive biomarkers for Alzheimer's disease using state-of-the-art brain imaging techniques. In Mandal, P.K. (Ed.). J Alzheimers Dis, 31 Suppl 3(s3), S1-S3.SAGE Publications. doi: 10.3233/JAD-2012-120731.
  • Mandal, P.K. (2012). In vivo proton magnetic resonance spectroscopic signal processing for the absolute quantitation of brain metabolites. Eur J Radiol, 81(4), e653-e664.Elsevier. doi: 10.1016/j.ejrad.2011.03.076.
  • Mandal, P.K., Akolkar, H., & Tripathi, M. (2012). Mapping of hippocampal pH and neurochemicals from in vivo multi-voxel 31P study in healthy normal young male/female, mild cognitive impairment, and Alzheimer's disease. In Mandal, P.K. (Ed.). J Alzheimers Dis, 31 Suppl 3(s3), S75-S86.SAGE Publications. doi: 10.3233/JAD-2012-120166.
  • Mandal, P.K., Joshi, J., & Saharan, S. (2012). Visuospatial perception: an emerging biomarker for Alzheimer's disease. In Mandal, P.K. (Ed.). J Alzheimers Dis, 31 Suppl 3(s3), S117-S135.SAGE Publications. doi: 10.3233/JAD-2012-120901.
  • Mandal, P.K., Mahajan, R., & Dinov, I.D. (2012). Structural brain atlases: design, rationale, and applications in normal and pathological cohorts. In Mandal, P.K. (Ed.). J Alzheimers Dis, 31 Suppl 3(0 3), S169-S188.SAGE Publications. doi: 10.3233/JAD-2012-120412.
  • Mandal, P.K., Tripathi, M., & Sugunan, S. (2012). Brain oxidative stress: detection and mapping of anti-oxidant marker 'Glutathione' in different brain regions of healthy male/female, MCI and Alzheimer patients using non-invasive magnetic resonance spectroscopy. Biochem Biophys Res Commun, 417(1), 43-48.Elsevier. doi: 10.1016/j.bbrc.2011.11.047.
  • Mandal, P.K., & Akolkar, H. (2011). A new experimental approach and signal processing scheme for the detection and quantitation of ³¹P brain neurochemicals from in vivo MRS studies using dual tuned (¹H/³¹P) head coil. Biochem Biophys Res Commun, 412(2), 302-306.Elsevier. doi: 10.1016/j.bbrc.2011.07.088.
  • Fodale, V., Ritchie, K., Rasmussen, L.S., & Mandal, P.K. (2010). Anesthetics and Alzheimer's disease: background and research. Preface. In Mandal, P.K., & Fodale, V. (Eds.). J Alzheimers Dis, 22 Suppl 3(s3), 1-3.SAGE Publications. doi: 10.3233/JAD-2010-100809.
  • Fodale, V., Santamaria, L.B., Schifilliti, D., & Mandal, P.K. (2010). Anaesthetics and postoperative cognitive dysfunction: a pathological mechanism mimicking Alzheimer's disease. Anaesthesia, 65(4), 388-395.Wiley. doi: 10.1111/j.1365-2044.2010.06244.x.
  • Mandal, P.K., & Ahuja, M. (2010). Comprehensive nuclear magnetic resonance studies on interactions of amyloid-β with different molecular sized anesthetics. In Mandal, P.K., & Fodale, V. (Eds.). J Alzheimers Dis, 22 Suppl 3(s3), 27-34.SAGE Publications. doi: 10.3233/JAD-2010-101128.
  • Mandal, P.K., & Fodale, V. (2010). Anesthetics and Alzheimer's disease. Editorial. In Mandal, P.K., & Fodale, V. (Eds.). J Alzheimers Dis, 22 Suppl 3(s3), 135-136.SAGE Publications. doi: 10.3233/JAD-2010-101300.
  • Mandal, P.K., Bhavesh, N.S., Chauhan, V.S., & Fodale, V. (2010). NMR investigations of amyloid-β peptide interactions with propofol at clinically relevant concentrations with and without aqueous halothane solution. J Alzheimers Dis, 21(4), 1303-1309.SAGE Publications. doi: 10.3233/jad-2010-100396.
  • Mandal, P.K., Simplaceanu, V., & Fodale, V. (2010). Intravenous anesthetic diazepam does not induce amyloid-beta peptide oligomerization but diazepam co-administered with halothane oligomerizes amyloid-beta peptide: an NMR study. J Alzheimers Dis, 20(1), 127-134.SAGE Publications. doi: 10.3233/JAD-2010-1350.
  • Mandal, P.K., Simplaceanu, V., & Fodale, V. (2010). Intravenous Anesthetic Diazepam Does Not Induce Amyloid-β Peptide Oligomerization but Diazepam Co-administered with Halothane Oligomerizes Amyloid-β Peptide: An NMR Study (vol 20, pg 127, 2010). JOURNAL OF ALZHEIMERS DISEASE, 20(4), 1261. doi: 10.3233/JAD-2010-01425.
  • Schifilliti, D., Santamaria, L.B., Rosa, G., Di Nino, G., Mandal, P.K., & Fodale, V. (2010). Cholinergic central system, Alzheimer's disease, and anesthetics liaison: a vicious circle?. In Mandal, P.K., & Fodale, V. (Eds.). J Alzheimers Dis, 22 Suppl 3(s3), 35-41.SAGE Publications. doi: 10.3233/JAD-2010-101317.
  • Mandal, P.K., & Fodale, V. (2009). Isoflurane and desflurane at clinically relevant concentrations induce amyloid beta-peptide oligomerization: an NMR study. Biochem Biophys Res Commun, 379(3), 716-720.Elsevier. doi: 10.1016/j.bbrc.2008.12.092.
  • Mandal, P.K., & Fodale, V. (2009). Smaller molecular-sized anaesthetics oligomerize Abeta peptide simulating Alzheimer's disease: a relevant issue. Eur J Anaesthesiol, 26(10), 805-806.Wolters Kluwer. doi: 10.1097/EJA.0b013e32832d6ae8.
  • Mandal, P.K., Schifilliti, D., Mafrica, F., & Fodale, V. (2009). Inhaled anesthesia and cognitive performance. Drugs Today (Barc), 45(1), 47-54.Portico. doi: 10.1358/dot.2009.45.1.1315075.
  • Mandal, P.K. (2008). Magnetic resonance spectroscopy (MRS) and its application in Alzheimer's disease (vol 30A, pg 40, 2007). CONCEPTS IN MAGNETIC RESONANCE PART A, 32A(5), 407.
  • Mandal, P.K., & Pettegrew, J.W. (2008). Clinically relevant concentration determination of inhaled anesthetics (halothane, isoflurane, sevoflurane, and desflurane) by 19F NMR. Cell Biochem Biophys, 52(1), 31-35.Springer Nature. doi: 10.1007/s12013-008-9022-7.
  • Mandal, P.K., & Pettegrew, J.W. (2008). Abeta peptide interactions with isoflurane, propofol, thiopental and combined thiopental with halothane: a NMR study. Biochim Biophys Acta, 1778(11), 2633-2639.Elsevier. doi: 10.1016/j.bbamem.2008.07.002.
  • Mandal, P.K. (2007). Magnetic resonance spectroscopy (MRS) and its application in Alzheimer's disease. CONCEPTS IN MAGNETIC RESONANCE PART A, 30A(1), 40-64.Wiley. doi: 10.1002/cmr.a.20072.
  • Mandal, P.K., Pettegrew, J.W., Masliah, E., Hamilton, R.L., & Mandal, R. (2006). Interaction between Abeta peptide and alpha synuclein: molecular mechanisms in overlapping pathology of Alzheimer's and Parkinson's in dementia with Lewy body disease. Neurochem Res, 31(9), 1153-1162.Springer Nature. doi: 10.1007/s11064-006-9140-9.
  • Mandal, P.K., & Majumdar, A. (2004). A comprehensive discussion of HSQC and HMQC pulse sequences. CONCEPTS IN MAGNETIC RESONANCE PART A, 20A(1), 1-23.Wiley. doi: 10.1002/cmr.a.10095.
  • Mandal, P.K., & Pettegrew, J.W. (2004). Alzheimer's disease: soluble oligomeric Abeta(1-40) peptide in membrane mimic environment from solution NMR and circular dichroism studies. Neurochem Res, 29(12), 2267-2272.Springer Nature. doi: 10.1007/s11064-004-7035-1.
  • Mandal, P.K., & Pettegrew, J.W. (2004). Alzheimer's disease: NMR studies of asialo (GM1) and trisialo (GT1b) ganglioside interactions with Abeta(1-40) peptide in a membrane mimic environment. Neurochem Res, 29(2), 447-453.Springer Nature. doi: 10.1023/b:nere.0000013750.80925.25.
  • Mandal, P.K., McClure, R.J., & Pettegrew, J.W. (2004). Interactions of Abeta(1-40) with glycerophosphocholine and intact erythrocyte membranes: fluorescence and circular dichroism studies. Neurochem Res, 29(12), 2273-2279.Springer Nature. doi: 10.1007/s11064-004-7036-0.
  • Yushmanov, V.E., Mandal, P.K., Liu, Z., Tang, P., & Xu, Y. (2003). NMR structure and backbone dynamics of the extended second transmembrane domain of the human neuronal glycine receptor alpha1 subunit. Biochemistry, 42(13), 3989-3995.American Chemical Society (ACS). doi: 10.1021/bi026767g.
  • Madhu, P.K., Mandal, P.K., & Müller, N. (2002). Cross-correlation effects involving curie spin relaxation in methyl groups. J Magn Reson, 155(1), 29-38.Elsevier. doi: 10.1006/jmre.2001.2496.
  • Mandal, P.K. (2002). Complete NMR spectroscopic assignment of a neuronal transduction protein. MONATSHEFTE FUR CHEMIE, 133(2), 205-217.Springer Nature. doi: 10.1007/s706-002-8252-5.
  • Tang, P., Mandal, P.K., & Xu, Y. (2002). NMR structures of the second transmembrane domain of the human glycine receptor alpha(1) subunit: model of pore architecture and channel gating. Biophys J, 83(1), 252-262.Elsevier. doi: 10.1016/S0006-3495(02)75166-7.
  • Tang, P., Mandal, P.K., & Zegarra, M. (2002). Effects of volatile anesthetic on channel structure of gramicidin A. Biophys J, 83(3), 1413-1420.Elsevier. doi: 10.1016/S0006-3495(02)73912-X.
  • Madhu, P.K., Grandori, R., Hohenthanner, K., Mandal, P.K., & Müller, N. (2001). Geometry dependent two-dimensional heteronuclear multiplet effects in paramagnetic proteins. J Biomol NMR, 20(1), 31-37.Springer Nature. doi: 10.1023/a:1011292410478.
  • Mandal, P.K., Madhu, P.K., & Müller, N. (2000). Nuclear magnetic relaxation of methyl protons in a paramagnetic protein: cross-correlation effects. CHEMICAL PHYSICS LETTERS, 320(3-4), 269-276.Elsevier. doi: 10.1016/S0009-2614(00)00243-8.
  • Schäffer, C., Müller, N., Mandal, P.K., Christian, R., Zayni, S., & Messner, P. (2000). A pyrophosphate bridge links the pyruvate-containing secondary cell wall polymer of Paenibacillus alvei CCM 2051 to muramic acid. Glycoconj J, 17(10), 681-690.Springer Nature. doi: 10.1023/a:1011062302889.
  • de Ropp, J.S., Mandal, P.K., & La Mar, G.N. (1999). Solution 1H NMR investigation of the heme cavity and substrate binding site in cyanide-inhibited horseradish peroxidase. Biochemistry, 38(3), 1077-1086.American Chemical Society (ACS). doi: 10.1021/bi982125a.
  • Tochio, H., Zhang, Q., Mandal, P., Li, M., & Zhang, M. (1999). Solution structure of the extended neuronal nitric oxide synthase PDZ domain complexed with an associated peptide. Nat Struct Biol, 6(5), 417-421.Springer Nature. doi: 10.1038/8216.
  • deRopp, J.S., Mandal, P., Brauer, S.L., & LaMar, G.N. (1997). Solution NMR study of the electronic and molecular structure of the heme cavity in high-spin, resting state horseradish peroxidase. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 119(20), 4732-4739.American Chemical Society (ACS). doi: 10.1021/ja9642018.
  • Mandal, P.K., Manoharan, P.T., Sinha, B., & Ramasesha, S. (1996). Diagrammatic valence bond studies on hemocyanin. THEORETICA CHIMICA ACTA, 93(1), 1-16.
  • Asokan, A., Mandal, P.K., Varghese, B., & Manoharan, P.T. (1995). Structure and magnetism of an exchange coupled system: An NMR approach. PROCEEDINGS OF THE INDIAN ACADEMY OF SCIENCES-CHEMICAL SCIENCES, 107(4), 281-295.
  • MANDAL, P.K., & MANOHARAN, P.T. (1995). A COMPREHENSIVE STUDY OF EXCHANGE COUPLING IN A MACROCYCLIC BINUCLEAR COPPER(II) COMPLEX IN THE SOLID AND SOLUTION STATES. INORGANIC CHEMISTRY, 34(1), 270-277.American Chemical Society (ACS). doi: 10.1021/ic00105a043.
  • MANDAL, P.K., & MANOHARAN, P.T. (1993). EFFECT OF THE 5TH COORDINATION SITE ON THE SPIN STATES OF BIS(BENZOYLACETYLACETANATO) BISPYRIDINEDICOPPER(II) COMPLEX. CHEMICAL PHYSICS LETTERS, 210(4-6), 463-470.Elsevier. doi: 10.1016/0009-2614(93)87054-7.
  • MANDAL, P.K., SINHA, B., MANOHARAN, P.T., & RAMASESHA, S. (1992). THEORETICAL-STUDIES OF THE SPIN STATES OF MACROCYCLIC AZA-AMIDO BINUCLEAR COPPER-(II) COMPLEXES. CHEMICAL PHYSICS LETTERS, 191(5), 448-454.Elsevier. doi: 10.1016/0009-2614(92)85407-2.
Research Interests
Biomedical engineering Signal processing Image processing Biomedical and clinical sciences
headshot of Pravat Mandal
Contact Pravat Mandal
Research Professor
Bioengineering Department
Work: 4126999561
Scholars@Pitt Profile