headshot of Corrine Kliment

Corrine Kliment

Associate Professor
CKLIMENT@pitt.edu
Website Bioengineering Department

overview

Corrine Kliment, MD, PhD, ATSF is an Associate Professor at University of Pittsburgh School of Medicine in the Division of Pulmonary, Allergy, Critical Care and Sleep Medicine. She is a physician scientist with a basic and translational laboratory investigating the intersection between mitochondria, cellular senescence and lung repair in lung diseases including COPD and pulmonary fibrosis. She is an associate program director for the Pulmonary and Critical Care Fellowship and the University of Pittsburgh MSTP MD/PhD Program. She has a passion for fostering career growth and is an active mentor for numerous physician scientists and trainees through her research program.

about

MD, University of Pittsburgh School of Medicine, 2004 - 2011

PhD, University of Pittsburgh School of Medicine, 2006 - 2009

Corcoran, T.E., Broerman, M.J., Kliment, C.R., & Lo, C. (2024). CFTR expression decreases with age in several airway cell types. Sci Rep, 14(1), 28832.Springer Nature. doi: 10.1038/s41598-024-80108-8.

Hu, Y., Hu, Q., Ansari, M., Riemondy, K., Pineda, R., Sembrat, J., Leme, A.S., Ngo, K., Morgenthaler, O., Ha, K., Gao, B., Janssen, W.J., Basil, M.C., Kliment, C.R., Morrisey, E., Lehmann, M., Evans, C.M., Schiller, H.B., & Königshoff, M. (2024). Airway-derived emphysema-specific alveolar type II cells exhibit impaired regenerative potential in COPD. Eur Respir J, 64(6), 2302071.European Respiratory Society (ERS). doi: 10.1183/13993003.02071-2023.

Sui, J., & Kliment, C. (2024). Reply to Kobayashi et al.: Adenine Nucleotide Translocases and Cellular Senescence in Idiopathic Pulmonary Fibrosis. Am J Respir Cell Mol Biol, 70(3), 226-227.American Thoracic Society. doi: 10.1165/rcmb.2023-0405LE.

Sui, J., Xiao, H., Mbaekwe, U., Ting, N.C., Murday, K., Hu, Q., Gregory, A.D., Kapellos, T.S., Yildirim, A.Ö., Königshoff, M., Zhang, Y., Sciurba, F., Das, J., & Kliment, C.R. (2024). Interpretable machine learning uncovers epithelial transcriptional rewiring and a role for Gelsolin in COPD. JCI Insight, 9(21), e180239.American Society for Clinical Investigation. doi: 10.1172/jci.insight.180239.

Ware, S.A., Kliment, C.R., Giordano, L., Redding, K.M., Rumsey, W.L., Bates, S., Zhang, Y., Sciurba, F.C., Nouraie, S.M., & Kaufman, B.A. (2024). Cell-free DNA levels associate with COPD exacerbations and mortality. Respir Res, 25(1), 42.Springer Nature. doi: 10.1186/s12931-023-02658-1.

Risbano, M.G., Kliment, C.R., Dunlap, D.G., Koch, C., Campedelli, L., Yoney, K., Nouraie, S.M., Sciurba, F., & Morris, A. (2023). Invasive Cardiopulmonary Exercise Testing Identifies Distinct Physiologic Endotypes in Postacute Sequelae of SARS-CoV-2 Infection. CHEST Pulmonary, 1(3), 100010.Elsevier. doi: 10.1016/j.chpulm.2023.100010.

Sui, J., Boatz, J.C., Shi, J., Hu, Q., Li, X., Zhang, Y., Königshoff, M., & Kliment, C.R. (2023). Loss of ANT1 Increases Fibrosis and Epithelial Cell Senescence in Idiopathic Pulmonary Fibrosis. Am J Respir Cell Mol Biol, 69(5), 556-569.American Thoracic Society. doi: 10.1165/rcmb.2022-0315OC.

Boatz, J.C., Sui, J., Hu, Q., Li, X., Zhang, Y., Königshoff, M., & Kliment, C.R. (2022). Loss of ANT1 Increases Fibrosis and Epithelial Cell Senescence in Idiopathic Pulmonary Fibrosis. In bioRxiv. doi: 10.1101/2022.09.09.507271.

Ghosh-Choudhary, S., Carleton, N., Nouraie, S.M., Kliment, C.R., & Steinman, R.A. (2022). Predoctoral MD-PhD grants as indicators of future NIH funding success. JCI Insight, 7(6), e155688.American Society for Clinical Investigation. doi: 10.1172/jci.insight.155688.

Kliment, C.R., & Gosens, R. (2022). Chymase-1: a "MAST"-er switch in COPD?. EUROPEAN RESPIRATORY JOURNAL, 60(6).

Kliment, C.R., Nguyen, J.M.K., Kaltreider, M.J., Lu, Y., Claypool, S.M., Radder, J.E., Sciurba, F.C., Zhang, Y., Gregory, A.D., Iglesias, P.A., Sidhaye, V.K., & Robinson, D.N. (2021). Adenine nucleotide translocase regulates airway epithelial metabolism, surface hydration and ciliary function. J Cell Sci, 134(4), jcs257162.The Company of Biologists. doi: 10.1242/jcs.257162.

Kliment, C.R., Barbash, I.J., Brenner, J.S., Chandra, D., Courtright, K., Gauthier, M.C., Robinson, K.M., Scheunemann, L.P., Shah, F.A., Christie, J.D., & Morris, A. (2020). COVID-19 and the Early-Career Physician-Scientist. Fostering Resilience beyond the Pandemic. ATS Sch, 2(1), 19-28.American Thoracic Society. doi: 10.34197/ats-scholar.2020-0104PS.

Zheng, M., Ramsay, A.J., Robichaux, M.B., Kliment, C., Crowe, C., Rapaka, R.R., Steele, C., McAllister, F., Shellito, J.E., Marrero, L., Schwarzenberger, P., Zhong, Q., & Kolls, J.K. (2015). Corrigendum. CD4+ T cell-independent DNA vaccination against opportunistic infections. J Clin Invest, 125(3), 1364.American Society for Clinical Investigation. doi: 10.1172/JCI81228.

Englert, J.M., Kliment, C.R., & Oury, T.D. (2014). Experimental Models of Asbestos-Related Diseases. In Pathology of Asbestos-Associated Diseases. (pp. 215-251).Springer Nature. doi: 10.1007/978-3-642-41193-9_10.

Englert, J.M., Kliment, C.R., Ramsgaard, L., Milutinovic, P.S., Crum, L., Tobolewski, J.M., & Oury, T.D. (2011). Paradoxical function for the receptor for advanced glycation end products in mouse models of pulmonary fibrosis. Int J Clin Exp Pathol, 4(3), 241-254.

Kliment, C.R., & Oury, T.D. (2011). Extracellular superoxide dismutase protects cardiovascular syndecan-1 from oxidative shedding. Free Radic Biol Med, 50(9), 1075-1080.Elsevier. doi: 10.1016/j.freeradbiomed.2011.02.014.

Kliment, C.R., Englert, J.M., Crum, L.P., & Oury, T.D. (2011). A novel method for accurate collagen and biochemical assessment of pulmonary tissue utilizing one animal. Int J Clin Exp Pathol, 4(4), 349-355.

Houghton, A.M., Rzymkiewicz, D.M., Ji, H., Gregory, A.D., Egea, E.E., Metz, H.E., Stolz, D.B., Land, S.R., Marconcini, L.A., Kliment, C.R., Jenkins, K.M., Beaulieu, K.A., Mouded, M., Frank, S.J., Wong, K.K., & Shapiro, S.D. (2010). Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth. Nat Med, 16(2), 219-223.Springer Nature. doi: 10.1038/nm.2084.

Kliment, C.R., & Oury, T.D. (2010). Oxidative stress, extracellular matrix targets, and idiopathic pulmonary fibrosis. Free Radic Biol Med, 49(5), 707-717.Elsevier. doi: 10.1016/j.freeradbiomed.2010.04.036.

Kliment, C.R., Clemens, K., & Oury, T.D. (2009). North american erionite-associated mesothelioma with pleural plaques and pulmonary fibrosis: a case report. Int J Clin Exp Pathol, 2(4), 407-410.

Kliment, C.R., Englert, J.M., Gochuico, B.R., Yu, G., Kaminski, N., Rosas, I., & Oury, T.D. (2009). Oxidative stress alters syndecan-1 distribution in lungs with pulmonary fibrosis. J Biol Chem, 284(6), 3537-3545.Elsevier. doi: 10.1074/jbc.M807001200.

Kliment, C.R., Suliman, H.B., Tobolewski, J.M., Reynolds, C.M., Day, B.J., Zhu, X., McTiernan, C.F., McGaffin, K.R., Piantadosi, C.A., & Oury, T.D. (2009). Extracellular superoxide dismutase regulates cardiac function and fibrosis. J Mol Cell Cardiol, 47(5), 730-742.Elsevier. doi: 10.1016/j.yjmcc.2009.08.010.

Carraway, M.S., Suliman, H.B., Kliment, C., Welty-Wolf, K.E., Oury, T.D., & Piantadosi, C.A. (2008). Mitochondrial biogenesis in the pulmonary vasculature during inhalational lung injury and fibrosis. Antioxid Redox Signal, 10(2), 269-275.Mary Ann Liebert. doi: 10.1089/ars.2007.1910.

Kliment, C.R., Tobolewski, J.M., Manni, M.L., Tan, R.J., Enghild, J., & Oury, T.D. (2008). Extracellular superoxide dismutase protects against matrix degradation of heparan sulfate in the lung. Antioxid Redox Signal, 10(2), 261-268.Mary Ann Liebert. doi: 10.1089/ars.2007.1906.

Myllärniemi, M., Lindholm, P., Ryynänen, M.J., Kliment, C.R., Salmenkivi, K., Keski-Oja, J., Kinnula, V.L., Oury, T.D., & Koli, K. (2008). Gremlin-mediated decrease in bone morphogenetic protein signaling promotes pulmonary fibrosis. Am J Respir Crit Care Med, 177(3), 321-329.American Thoracic Society. doi: 10.1164/rccm.200706-945OC.

Zheng, M., Ramsay, A.J., Robichaux, M.B., Kliment, C., Crowe, C., Rapaka, R.R., Steele, C., McAllister, F., Shellito, J.E., Marrero, L., Schwarzenberger, P., Zhong, Q., & Kolls, J.K. (2005). CD4+ T cell-independent DNA vaccination against opportunistic infections. J Clin Invest, 115(12), 3536-3544.American Society for Clinical Investigation. doi: 10.1172/JCI26306.