Andrew Gerlach

Dr. Andrew Gerlach is a nuclear engineer by training, now applying his computational expertise to multimodal neuroimaging integration. His focus is on exploring the underlying neurobiology and treatment response of late-life depression and anxiety. In his free time, he enjoys just about anything that will take him and his family into wild spaces, especially rock climbing.

  • PhD, Nuclear Engineering and Radiological Sciences, University of Michigan
  • MSE, Nuclear Engineering and Radiological Sciences, University of Michigan
  • BSE, Nuclear Engineering and Radiological Sciences, University of Michigan

  • Taylor, W.D., Gerlach, A.R., Szymkowicz, S.M., Gujral, S., & Andreescu, C. (2026). Remission is insufficient: predictors and mechanistic models of recurrence in late-life depression. Neuropsychopharmacology.Springer Nature. doi: 10.1038/s41386-026-02324-2.
  • Gerlach, A.R., Karim, H.T., Kahru, K., Tudorascu, D.L., Gross, J.J., Butters, M.A., & Andreescu, C. (2025). The Desegregation of Neural Networks During Worry Induction in Late Life: An Effective Connectivity Analysis. Biol Psychiatry Cogn Neurosci Neuroimaging, 10(11), 1143-1154.Elsevier. doi: 10.1016/j.bpsc.2025.04.010.
  • Gerlach, A.R., Karim, H.T., Kolobaric, A., Boyd, B.D., Kahru, K., Krafty, R.T., Ajilore, O., Taylor, W.D., & Andreescu, C. (2025). Network homeostasis: functional brain network alterations and relapse in remitted late-life depression. Neuropsychopharmacology, 50(10), 1493-1501.Springer Nature. doi: 10.1038/s41386-025-02138-8.
  • Karim, H.T., Gross, J.J., Mennin, D., Gerlach, A., Tudorascu, D.L., Butters, M.A., Ladouceur, C., & Andreescu, C. (2025). Older and wiser? The neural correlates of worry induction and reappraisal in older adults. Neuropsychopharmacology, 50(13), 1949-1958.Springer Nature. doi: 10.1038/s41386-025-02193-1.
  • gerlach, A., Karim, H.T., kolobaric, A., boyd, B., Kahru, K., Krafty, R., Ajilore, O., Talyor, W., & Andreescu, C. (2024). Network homeostasis: functional brain network alterations and relapse in remitted late-life depression. In Research Square. doi: 10.21203/rs.3.rs-5005391/v1.
  • Gerlach, A.R., Karim, H.T., Lee, S., Kolobaric, A., Tudorascu, D.L., Butters, M.A., & Andreescu, C. (2024). White Noise-Is Anxiety in Late-Life Associated With White Matter Hyperintensity Burden?. Am J Geriatr Psychiatry, 32(1), 83-97.Elsevier. doi: 10.1016/j.jagp.2023.08.014.
  • McGaffey, A., Castelli, G., Friedlander, M.P., Proddutur, S., Simpkins, C., Middleton, D.B., Spencer, K.O., Taormina, J.M., Gerlach, A., & Nowalk, M.P. (2024). Going (Anti)Viral: Improving HIV and HCV Screening and HPV Vaccination in Primary Care. Jt Comm J Qual Patient Saf, 50(9), 645-654.Elsevier. doi: 10.1016/j.jcjq.2024.06.002.
  • Gerlach, A.R., & Gunning, F.M. (2023). An Illustrative Commentary on Machine Learning in Psychiatric Research. Am J Geriatr Psychiatry, 31(11), 916-918.Elsevier. doi: 10.1016/j.jagp.2023.07.003.
  • Kazan, J., Gerlach, A.R., Mizuno, A., Andreescu, C., Aizenstein, H.J., Ward, S., Buente, K.J., & Stahl, S.T. (2023). Depressive symptoms anticipate behavioral and emotional factors among older adults: A prospective cross-lagged panel design. Psychiatry Res Commun, 3(1).Elsevier. doi: 10.1016/j.psycom.2022.100096.
  • Szymkowicz, S.M., Gerlach, A.R., Homiack, D., & Taylor, W.D. (2023). Biological factors influencing depression in later life: role of aging processes and treatment implications. Transl Psychiatry, 13(1), 160.Springer Nature. doi: 10.1038/s41398-023-02464-9.
  • Wilson, J.D., Gerlach, A.R., Karim, H.T., Aizenstein, H.J., & Andreescu, C. (2023). Sex matters: acute functional connectivity changes as markers of remission in late-life depression differ by sex. Mol Psychiatry, 28(12), 5228-5236.Springer Nature. doi: 10.1038/s41380-023-02158-0.
  • Gerlach, A.R., Karim, H.T., Peciña, M., Ajilore, O., Taylor, W.D., Butters, M.A., & Andreescu, C. (2022). MRI predictors of pharmacotherapy response in major depressive disorder. Neuroimage Clin, 36, 103157.Elsevier. doi: 10.1016/j.nicl.2022.103157.
  • Kazan, J., Gerlach, A.R., Mizuno, A., Andreescu, C., Aizenstein, H.J., Ward, S., Buente, K.J., & Stahl, S.T. (2022). Depressive symptoms anticipate behavioral and emotional factors among older adults: A prospective cross-lagged panel design. 2022.08.31.22279439.Cold Spring Harbor Laboratory. doi: 10.1101/2022.08.31.22279439.
  • Gerlach, A.R., Karim, H.T., Kazan, J., Aizenstein, H.J., Krafty, R.T., & Andreescu, C. (2021). Networks of worry-towards a connectivity-based signature of late-life worry using higher criticism. Transl Psychiatry, 11(1), 550.Springer Nature. doi: 10.1038/s41398-021-01648-5.
  • Cao, L., Gerlach, A., Xu, Y., Downar, T., & Lee, J.C. (2015). Neutronics modeling of the SPERT III E-Core critical experiments with MPACT and KENO. ANNALS OF NUCLEAR ENERGY, 80, 207-218.Elsevier. doi: 10.1016/j.anucene.2015.02.013.

  • Gerlach, A., Wilson, J., Karim, H., Aizenstein, H., & Andreescu, C. (2022). Sex Moderates the Relationship Between Functional Connectivity and Remission in Late-Life Depression. In NEUROPSYCHOPHARMACOLOGY, 47, (pp. 285-286).
  • Gerlach, A., Karim, H., Krafty, R., Aizenstein, H., & Andreescu, C. (2021). Neural Markers of Worry - Functional Connectivity Correlations Using Higher Criticism. In NEUROPSYCHOPHARMACOLOGY, 46(SUPPL 1), (p. 110).
  • Kazan, J., Gerlach, A., Mizuno, A., Aizenstein, H., & Stahl, S. (2021). Temporal Relations Among Emotional and Behavioral Factors in Late-Life Depression During the COVID-19 Pandemic. In NEUROPSYCHOPHARMACOLOGY, 46(SUPPL 1), (pp. 77-78).
Research Interests
Biological psychology Clinical sciences Neurosciences Clinical and health psychology Health services and systems
headshot of Andrew Gerlach
Contact Andrew Gerlach
Assistant Professor
gerlachar@upmc.edu
Website
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Bioengineering Department