Amanda Clark

Dai, B., Clark, A.M., & Wells, A. (2024). Mesenchymal Stem Cell-Secreted Exosomes and Soluble Signals Regulate Breast Cancer Metastatic Dormancy: Current Progress and Future Outlook. Int J Mol Sci, 25(13), 7133.MDPI AG. doi: 10.3390/ijms25137133.

McDonald, J.C., & Clark, A.M. (2024). Modeling Tumor Cell Dormancy in an Ex Vivo Liver Metastatic Niche. Methods Mol Biol, 2811, 37-53.Springer US. doi: 10.1007/978-1-0716-3882-8_3.

Korentzelos, D., Wells, A., & Clark, A.M. (2022). Interferon-γ increases sensitivity to chemotherapy and provides immunotherapy targets in models of metastatic castration-resistant prostate cancer. SCIENTIFIC REPORTS, 12(1), 6657.Springer Science and Business Media LLC. doi: 10.1038/s41598-022-10724-9.

Clark, A.M. (2021). Modeling the Complexity of the Metastatic Niche Ex Vivo. Methods Mol Biol, 2258, 221-239.Springer US. doi: 10.1007/978-1-0716-1174-6_15.

Clark, A.M., Allbritton, N.L., & Wells, A. (2021). Integrative microphysiological tissue systems of cancer metastasis to the liver. SEMINARS IN CANCER BIOLOGY, 71, 157-169.Elsevier BV. doi: 10.1016/j.semcancer.2020.06.010.

Clark, A.M., Heusey, H.L., Griffith, L.G., Lauffenburger, D.A., & Wells, A. (2021). IP-10 (CXCL10) Can Trigger Emergence of Dormant Breast Cancer Cells in a Metastatic Liver Microenvironment. FRONTIERS IN ONCOLOGY, 11, 676135.Frontiers Media SA. doi: 10.3389/fonc.2021.676135.

Clark, A.M., Magawa, C., Pliego-Zamora, A., Low, P., Reynolds, M., & Ralph, S.J. (2021). Tea tree oil extract causes mitochondrial superoxide production and apoptosis as an anticancer agent, promoting tumor infiltrating neutrophils cytotoxic for breast cancer to induce tumor regression. BIOMEDICINE & PHARMACOTHERAPY, 140, 111790.Elsevier BV. doi: 10.1016/j.biopha.2021.111790.

Marti, J.L.G., Beckwitt, C.H., Clark, A.M., & Wells, A. (2021). Atorvastatin facilitates chemotherapy effects in metastatic triple-negative breast cancer. BRITISH JOURNAL OF CANCER, 125(9), 1285-1298.Springer Science and Business Media LLC. doi: 10.1038/s41416-021-01529-0.

Korentzelos, D., Clark, A.M., & Wells, A. (2020). A Perspective on Therapeutic Pan-Resistance in Metastatic Cancer. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(19), 7304.MDPI AG. doi: 10.3390/ijms21197304.

Ma, B., Wells, A., & Clark, A.M. (2020). The pan-therapeutic resistance of disseminated tumor cells: Role of phenotypic plasticity and the metastatic microenvironment. SEMINARS IN CANCER BIOLOGY, 60, 138-147.Elsevier BV. doi: 10.1016/j.semcancer.2019.07.021.

Jiang, Y., Wells, A., Sylakowski, K., Clark, A.M., & Ma, B. (2019). Adult Stem Cell Functioning in the Tumor Micro-Environment. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(10), 2566.MDPI AG. doi: 10.3390/ijms20102566.

Beckwitt, C.H., Clark, A.M., Ma, B., Whaley, D., Oltvai, Z.N., & Wells, A. (2018). Statins attenuate outgrowth of breast cancer metastases. BRITISH JOURNAL OF CANCER, 119(9), 1094-1105.Springer Science and Business Media LLC. doi: 10.1038/s41416-018-0267-7.

Beckwitt, C.H., Clark, A.M., Wheeler, S., Taylor, D.L., Stolz, D.B., Griffith, L., & Wells, A. (2018). Liver 'organ on a chip'. EXPERIMENTAL CELL RESEARCH, 363(1), 15-25.Elsevier BV. doi: 10.1016/j.yexcr.2017.12.023.

Clark, A.M., Kumar, M.P., Wheeler, S.E., Young, C.L., Venkataramanan, R., Stolz, D.B., Griffith, L.G., Lauffenburger, D.A., & Wells, A. (2018). A Model of Dormant-Emergent Metastatic Breast Cancer Progression Enabling Exploration of Biomarker Signatures. MOLECULAR & CELLULAR PROTEOMICS, 17(4), 619-630.Elsevier BV. doi: 10.1074/mcp.RA117.000370.

Khazali, A.S., Clark, A.M., & Wells, A. (2018). Inflammatory cytokine IL-8/CXCL8 promotes tumour escape from hepatocyte-induced dormancy. BRITISH JOURNAL OF CANCER, 118(4), 566-576.Springer Science and Business Media LLC. doi: 10.1038/bjc.2017.414.

Wells, A., Clark, A., Bradshaw, A., Ma, B., & Edington, H. (2018). The great escape: How metastases of melanoma, and other carcinomas, avoid elimination. EXPERIMENTAL BIOLOGY AND MEDICINE, 243(17-18), 1245-1255.Frontiers Media SA. doi: 10.1177/1535370218820287.

Clark, A.M., Wheeler, S.E., Young, C.L., Stockdale, L., Neiman, J.S., Zhao, W., Stolz, D.B., Venkataramanan, R., Lauffenburger, D., Griffith, L., & Wells, A. (2017). A liver microphysiological system of tumor cell dormancy and inflammatory responsiveness is affected by scaffold properties. LAB ON A CHIP, 17(1), 156-168.Royal Society of Chemistry (RSC). doi: 10.1039/c6lc01171c.

Dioufa, N., Clark, A.M., Ma, B., Beckwitt, C.H., & Wells, A. (2017). Bi-directional exosome-driven intercommunication between the hepatic niche and cancer cells. MOLECULAR CANCER, 16(1), 172.Springer Science and Business Media LLC. doi: 10.1186/s12943-017-0740-6.

Khazali, A.S., Clark, A.M., & Wells, A. (2017). A Pathway to Personalizing Therapy for Metastases Using Liver-on-a-Chip Platforms. STEM CELL REVIEWS AND REPORTS, 13(3), 364-380.Springer Science and Business Media LLC. doi: 10.1007/s12015-017-9735-3.

Clark, A.M., Ma, B., Taylor, D.L., Griffith, L., & Wells, A. (2016). Liver metastases: Microenvironments and ex-vivo models. EXPERIMENTAL BIOLOGY AND MEDICINE, 241(15), 1639-1652.Frontiers Media SA. doi: 10.1177/1535370216658144.

Ma, B., Wheeler, S.E., Clark, A.M., Whaley, D.L., Yang, M., & Wells, A. (2016). Liver protects metastatic prostate cancer from induced death by activating E-cadherin signaling. HEPATOLOGY, 64(5), 1725-1742.Ovid Technologies (Wolters Kluwer Health). doi: 10.1002/hep.28755.

Yang, M., Ma, B., Shao, H., Clark, A.M., & Wells, A. (2016). Macrophage phenotypic subtypes diametrically regulate epithelial-mesenchymal plasticity in breast cancer cells. BMC CANCER, 16(1), 419.Springer Science and Business Media LLC. doi: 10.1186/s12885-016-2411-1.

Clark, A.M., Wheeler, S.E., Taylor, D.P., Young, C.L., Pillai, V.C., Stolz, D.B., Venkataramanan, R., Lauffenburger, D.A., Griffith, L.G., & Wells, A. (2015). Modeling breast cancer dormancy and re-emergence. CANCER RESEARCH, 75(9_Supplement).American Association for Cancer Research (AACR). doi: 10.1158/1538-7445.SABCS14-P1-07-01.

Furukawa, M., Wheeler, S., Clark, A.M., & Wells, A. (2015). Lung Epithelial Cells Induce Both Phenotype Alteration and Senescence in Breast Cancer Cells. In Samant, R. (Ed.). PLOS ONE, 10(1), e0118060.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0118060.

Low, P., Clark, A.M., Chou, T.C., Chang, T.C., Reynolds, M., & Ralph, S.J. (2015). Immunomodulatory activity of Melaleuca alternifolia concentrate (MAC): inhibition of LPS-induced NF-κB activation and cytokine production in myeloid cell lines. Int Immunopharmacol, 26(1), 257-264.Elsevier BV. doi: 10.1016/j.intimp.2015.03.034.

Clark, A.M., Wheeler, S.E., Taylor, D.P., Pillai, V.C., Young, C.L., Prantil-Baun, R., Nguyen, T., Stolz, D.B., Borenstein, J.T., Lauffenburger, D.A., Venkataramanan, R., Griffith, L.G., & Wells, A. (2014). A microphysiological system model of therapy for liver micrometastases. EXPERIMENTAL BIOLOGY AND MEDICINE, 239(9), 1170-1179.Frontiers Media SA. doi: 10.1177/1535370214532596.

Taylor, D.P., Clark, A., Wheeler, S., & Wells, A. (2014). Hepatic nonparenchymal cells drive metastatic breast cancer outgrowth and partial epithelial to mesenchymal transition. BREAST CANCER RESEARCH AND TREATMENT, 144(3), 551-560.Springer Science and Business Media LLC. doi: 10.1007/s10549-014-2875-0.

Wheeler, S.E., Clark, A.M., Taylor, D.P., Young, C.L., Pillai, V.C., Stolz, D.B., Venkataramanan, R., Lauffenburger, D., Griffith, L., & Wells, A. (2014). Spontaneous dormancy of metastatic breast cancer cells in an all human liver microphysiologic system. BRITISH JOURNAL OF CANCER, 111(12), 2342-2350.Springer Science and Business Media LLC. doi: 10.1038/bjc.2014.533.

Wheeler, S.E., Borenstein, J.T., Clark, A.M., Ebrahimkhani, M., Fox, I.J., Griffith, L., Inman, W., Lauffenburger, D., Nguyen, T., Pillai, V.C., Prantil-Baun, R., Stolz, D.B., Taylor, D., Ulrich, T., Venkataramanan, R., Wells, A., & Young, C. (2013). All-human microphysical model of metastasis therapy. STEM CELL RESEARCH & THERAPY, 4(Suppl 1), S11.Springer Science and Business Media LLC. doi: 10.1186/scrt372.

Ito, K., Stannard, K., Gabutero, E., Clark, A.M., Neo, S.Y., Onturk, S., Blanchard, H., & Ralph, S.J. (2012). Galectin-1 as a potent target for cancer therapy: role in the tumor microenvironment. Cancer and Metastasis Reviews, 31(3-4), 763-778.Springer Science and Business Media LLC. doi: 10.1007/s10555-012-9388-2.

Horton, R.E., Grant, G.D., Matthews, B., Batzloff, M., Owen, S.J., Kyan, S., Flegg, C.P., Clark, A.M., Ulett, G.C., Morrison, N., Peak, I.R., & Beacham, I.R. Quorum Sensing Negatively Regulates Multinucleate Cell Formation during Intracellular Growth of Burkholderia pseudomallei in Macrophage-Like Cells. PLoS ONE, 8(5), e63394.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0063394.

Oesterreich, S., Miller, L., Rosenzweig, M.Q., Bartholow, T.L., Yates, M., Elangovan, A., Savariau, L., Casey, A.N., Priedigkeit, N., Ding, K., Wedn, A., Bin Liu, J., Brown, D.D., Hyder, T., Pecar, G., Carleton, N., Bittar, H.T., Geisler, D., Lopez-Nunez, O., Clark, A.M., Wells, A., Roy, P., Puhalla, S., Howard, N., Needles, C., Trent, S., Walker, S., Hodgdon, C., Bhargava, R., Atkinson, J.M., & Lee, A.V. (2023). Hope for OTHERS - An organ donation program for metastatic breast cancer research. In CANCER RESEARCH, 83(5).American Association for Cancer Research (AACR). doi: 10.1158/1538-7445.SABCS22-P6-14-02.

Beckwitt, C.H., Clark, A.M., Warita, K., Oltvai, Z.N., & Wells, A. (2018). Adjuvant statin therapy efficacy is dictated by tumor dormancy and statin lipophilicity in ex vivo and in vivo models of metastatic breast cancer. In CANCER RESEARCH, 78(4).

Beckwitt, C.H., Clark, A.M., Warita, K., Oltvai, Z.N., & Wells, A. (2017). Adjuvant Statin Therapy Efficacy is Dictated by Tumor Dormancy and Statin Lipophilicity in Ex Vivo and In Vivo Models of Metastatic Breast Cancer. In FASEB JOURNAL, 31.

Clark, A.M., Dioufa, N., Chan, K., Edington, C.D., Kumar, M., Wheeler, S.E., Venkataramanan, R., Stolz, D.B., Trumper, D., Griffith, L., Lauffenburger, D., & Wells, A. (2017). A Multi-Organ Microphysiological System that Models Dormant-Emergent Metastatic Breast Cancer Progression. In AMERICAN JOURNAL OF PATHOLOGY, 187(10), (p. 2356).

Clark, A.M., Wheeler, S.E., Young, C.L., Neiman, J.S., Pillai, V., Stockdale, L., Stolz, D., Lauffenburger, D.A., Venkataramanan, R., Griffith, L.G., & Wells, A. (2017). Mechanical properties of matrices strongly influence spontaneous tumor dormancy and responses to chemotherapy in a 3D model of metastasis. In CANCER RESEARCH, 77(2_Supplement), (p. A01).American Association for Cancer Research (AACR). doi: 10.1158/1538-7445.EPSO16-A01.

Edington, C.D., Cirit, M., Chen, W.L.K., Clark, A.M., Wells, A., Trumper, D.L., & Griffith, L.G. (2017). Integration of systems biology with organs-on-chips to humanize therapeutic development. In SPIE Proceedings, 10061, (p. 1006113).SPIE. doi: 10.1117/12.2256078.

Beckwitt, C., Wheeler, S.E., Clark, A.M., Pillai, V.C., Young, C.L., Stolz, D.B., Lauffenburger, D.A., Venkataramanan, R., Griffith, L.G., & Wells, A. (2016). Breast cancer dormancy, re-emergence, and treatment. In CANCER RESEARCH, 76(4_Supplement).American Association for Cancer Research (AACR). doi: 10.1158/1538-7445.SABCS15-P2-05-19.

Clark, A.M., Wheeler, S.E., Young, C.L., Pillai, V.C., Stolz, D.B., Lauffenburger, D.A., Venkataramanan, R., Griffith, L.G., & Wells, A. (2016). Elucidating candidate biomarkers of breast cancer progression and dormancy using a 3D model of metastasis. In CANCER RESEARCH, 76(7_Supplement), (p. A41).American Association for Cancer Research (AACR). doi: 10.1158/1538-7445.TUMMET15-A41.

Clark, A.M., Wheeler, S.E., Young, C.L., Pillai, V.C., Stolz, D.B., Lauffenburger, D.A., Venkataramanan, R., Griffith, L.G., & Wells, A. (2016). Elucidating candidate biomarkers of breast cancer progression and dormancy using a 3D model of metastasis. In CANCER RESEARCH, 76(7_Supplement), (p. PR11).American Association for Cancer Research (AACR). doi: 10.1158/1538-7445.TUMMET15-PR11.

Khazali, A.S., Clark, A., Wheeler, S., & Wells, A. (2016). Breast Cancer Emergence from Dormancy can be Activated by Hepatic Stellate Cells. In FASEB JOURNAL, 30.

Nguyen, T.V., Kim, E.S., Coppeta, J.R., Wheeler, S.E., Clark, A.M., Lever, A.R., Cirit, M., Yu, J., Spencer, A.J., Sinatra, F.L., Prantil-Baun, R., Wells, A., Griffith, L.G., & Borenstein, J.T. (2014). Automated reagent delivery, media replenishment, and media sampling platform for open cell culture systems. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, (pp. 491-493).

Wheeler, S.E., Taylor, D.P., Clark, A.M., Borenstein, J.T., Ebrahimkhani, M.R., Inman, W., Nguyen, T., Pillai, V.C., Prantil-Baun, R., Ulrich, T.A., Venkataramanan, R., Lauffenburger, D.A., Griffith, L., Stolz, D.B., & Wells, A. (2013). Modeling breast cancer dormancy. In CANCER RESEARCH, 73(24_Supplement).American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.SABCS13-P5-04-08.