headshot of Alan Wells

Alan Wells

Bioengineering Department


Shao, H., Teramae, D., & Wells, A. (2023). Axl contributes to efficient migration and invasion of melanoma cells. PLOS ONE, 18(3), e0283749.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0283749.

Gomez Marti, J.L., Brufsky, A., Wells, A., & Jiang, X. (2022). Machine Learning to Discern Interactive Clusters of Risk Factors for Late Recurrence of Metastatic Breast Cancer. CANCERS, 14(1), 253.MDPI AG. doi: 10.3390/cancers14010253.

Korentzelos, D., Wells, A., & Clark, A.M. (2022). Interferon-γ increases sensitivity to chemotherapy and provides immunotherapy targets in models of metastatic castration-resistant prostate cancer. SCIENTIFIC REPORTS, 12(1), 6657.Springer Science and Business Media LLC. doi: 10.1038/s41598-022-10724-9.

Ma, B., Shao, H., Jiang, X., Wang, Z., Wu, C.C., Whaley, D., & Wells, A. (2022). Akt isoforms differentially provide for chemoresistance in prostate cancer. CANCER BIOLOGY & MEDICINE, 19(5), 635-650.China Anti-cancer Association. doi: 10.20892/j.issn.2095-3941.2020.0747.

Popescu, I., Snyder, M.E., Iasella, C.J., Hannan, S.J., Koshy, R., Burke, R., Das, A., Brown, M.J., Lyons, E.J., Lieber, S.C., Chen, X., Sembrat, J.C., Bhatt, P., Deng, E., An, X., Linstrum, K., Kitsios, G., Konstantinidis, I., Saul, M., Kass, D.J., Alder, J.K., Chen, B.B., Lendermon, E.A., Kilaru, S., Johnson, B., Pilewski, J.M., Kiss, J.E., Wells, A.H., Morris, A., McVerry, B.J., McMahon, D.K., Triulzi, D.J., Chen, K., Sanchez, P.G., & McDyer, J.F. (2022). CD4+ T-Cell Dysfunction in Severe COVID-19 Disease Is Tumor Necrosis Factor-α/Tumor Necrosis Factor Receptor 1-Dependent. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 205(12), 1403-1418.American Thoracic Society. doi: 10.1164/rccm.202111-2493OC.

Sylakowski, K., Hwang, M.P., Justin, A., Whaley, D., Wang, Y., & Wells, A. (2022). The matricellular protein decorin delivered intradermally with coacervate improves wound resolution in the CXCR3-deficient mouse model of hypertrophic scarring. WOUND REPAIR AND REGENERATION, 30(4), 436-447.Wiley. doi: 10.1111/wrr.13017.

Sylakowski, K., Hwang, P., Justin, A., Shao, H., Whaley, D., Wang, Y., & Wells, A. (2022). Matricellular protein Tenascin-C enhances mesenchymal stem cell angiogenic and wound healing efficacy under ischemic conditions. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 16(12), 1249-1260.Hindawi Limited. doi: 10.1002/term.3367.

Zhu, L., Marsh, J.W., Griffith, M.P., Collins, K., Srinivasa, V., Waggle, K., Van Tyne, D., Snyder, G.M., Phan, T., Wells, A., Marroquin, O.C., & Harrison, L.H. (2022). Predictive model for severe COVID-19 using SARS-CoV-2 whole-genome sequencing and electronic health record data, March 2020-May 2021. PLOS ONE, 17(7), e0271381.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0271381.

Agha, M., Blake, M., Chilleo, C., Wells, A., & Haidar, G. (2021). Suboptimal response to COVID-19 mRNA vaccines in hematologic malignancies patients. medRxiv.Cold Spring Harbor Laboratory. doi: 10.1101/2021.04.06.21254949.

Clark, A.M., Allbritton, N.L., & Wells, A. (2021). Integrative microphysiological tissue systems of cancer metastasis to the liver. SEMINARS IN CANCER BIOLOGY, 71, 157-169.Elsevier BV. doi: 10.1016/j.semcancer.2020.06.010.

Clark, A.M., Heusey, H.L., Griffith, L.G., Lauffenburger, D.A., & Wells, A. (2021). IP-10 (CXCL10) Can Trigger Emergence of Dormant Breast Cancer Cells in a Metastatic Liver Microenvironment. FRONTIERS IN ONCOLOGY, 11, 676135.Frontiers Media SA. doi: 10.3389/fonc.2021.676135.

Haidar, G., Ayres, A., King, W.C., McDonald, M., Wells, A., Mitchell, S.L., Bilderback, A.L., Minnier, T., & Mellors, J.W. (2021). Preprocedural SARS-CoV-2 Testing to Sustain Medically Needed Health Care Delivery During the COVID-19 Pandemic: A Prospective Observational Study. OPEN FORUM INFECTIOUS DISEASES, 8(2), ofab022.Oxford University Press (OUP). doi: 10.1093/ofid/ofab022.

Huang, D.T., McCreary, E.K., Bariola, J.R., Wadas, R.J., Kip, K.E., Marroquin, O.C., Koscumb, S., Collins, K., Shovel, J.A., Schmidhofer, M., Wisniewski, M.K., Sullivan, C., Yealy, D.M., Axe, M., Nace, D.A., Haidar, G., Khadem, T., Linstrum, K., Snyder, G.M., Seymour, C.W., Montgomery, S.K., McVerry, B.J., Berry, L., Berry, S., Meyers, R., Weissman, A., Peck-Palmer, O.M., Wells, A., Bart, R., Albin, D.L., Minnier, T., & Angus, D.C. (2021). The UPMC OPTIMISE-C19 (OPtimizing Treatment and Impact of Monoclonal antIbodieS through Evaluation for COVID-19) trial: a structured summary of a study protocol for an open-label, pragmatic, comparative effectiveness platform trial with response-adaptive randomization. TRIALS, 22(1), 363.Springer Science and Business Media LLC. doi: 10.1186/s13063-021-05316-3.

Ma, B., Wells, A., Wei, L., & Zheng, J. (2021). Prostate cancer liver metastasis: Dormancy and resistance to therapy. SEMINARS IN CANCER BIOLOGY, 71, 2-9.Elsevier BV. doi: 10.1016/j.semcancer.2020.07.004.

Marti, J.L.G., Beckwitt, C.H., Clark, A.M., & Wells, A. (2021). Atorvastatin facilitates chemotherapy effects in metastatic triple-negative breast cancer. BRITISH JOURNAL OF CANCER, 125(9), 1285-1298.Springer Science and Business Media LLC. doi: 10.1038/s41416-021-01529-0.

Marti, J.L.G., Wells, A., & Brufsky, A.M. (2021). Dysregulation of the mevalonate pathway during SARS-CoV-2 infection: An in silico study. JOURNAL OF MEDICAL VIROLOGY, 93(4), 2396-2405.Wiley. doi: 10.1002/jmv.26743.

Shao, H., & Wells, A. (2021). Binding of alpha-ACTN4 to EGF receptor enables its rapid phosphorylation. HELIYON, 7(1), e06011.Elsevier BV. doi: 10.1016/j.heliyon.2021.e06011.

Swogger, J., Conner, I.P., Happ-Smith, C., Kemmerer, M.C., Julian, D.R., Wells, A., Schuman, J.S., Yates, C.C., & Davis, R. (2021). Novel combination therapy reduces subconjunctival fibrosis after glaucoma filtration surgery in the rabbit model. CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 49(1), 60-69.Wiley. doi: 10.1111/ceo.13884.

Sylakowski, K., & Wells, A. (2021). ECM-regulation of autophagy: The yin and the yang of autophagy during wound healing. MATRIX BIOLOGY, 100, 197-206.Elsevier BV. doi: 10.1016/j.matbio.2020.12.006.

Wells, A., Beckwitt, C., & Marti, J.L.G. (2021). Preventing metastatic emergence of breast cancer. AGING-US, 13(19), 22627-22628.Impact Journals, LLC. doi: 10.18632/aging.203631.

Xu, L., Doyle, J., Barbeau, D.J., Le Sage, V., Wells, A., Duprex, W.P., Shurin, M.R., Wheeler, S.E., & McElroy, A.K. (2021). A Cross-Sectional Study of SARS-CoV-2 Seroprevalence between Fall 2020 and February 2021 in Allegheny County, Western Pennsylvania, USA. PATHOGENS, 10(6), 710.MDPI AG. doi: 10.3390/pathogens10060710.

Zilla, M., Wheeler, B.J., Keetch, C., Mitchell, G., McBreen, J., Wells, A., Shurin, M.R., Peck-Palmer, O., & Wheeler, S.E. (2021). Variable Performance in 6 Commercial SARS-CoV-2 Antibody Assays May Affect Convalescent Plasma and Seroprevalence Screening. AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 155(3), 343-353.Oxford University Press (OUP). doi: 10.1093/AJCP/AQAA228.

Jiang, X., Wells, A., Brufsky, A., Shetty, D., Shajihan, K., & Neapolitan, R.E. (2020). Leveraging Bayesian networks and information theory to learn risk factors for breast cancer metastasis. BMC BIOINFORMATICS, 21(1), 298.Springer Science and Business Media LLC. doi: 10.1186/s12859-020-03638-8.

Klimstra, W.B., Tilston-Lunel, N.L., Nambulli, S., Boslett, J., McMillen, C.M., Gilliland, T., Dunn, M.D., Sun, C., Wheeler, S.E., Wells, A., Hartman, A.L., McElroy, A.K., Reed, D.S., Rennick, L.J., & Duprex, W.P. (2020). SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected hospitalized COVID-19 patients. JOURNAL OF GENERAL VIROLOGY, 101(11), 1156-1169.Microbiology Society. doi: 10.1099/jgv.0.001481.

Korentzelos, D., Clark, A.M., & Wells, A. (2020). A Perspective on Therapeutic Pan-Resistance in Metastatic Cancer. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(19), 7304.MDPI AG. doi: 10.3390/ijms21197304.

Ma, B., Wells, A., & Clark, A.M. (2020). The pan-therapeutic resistance of disseminated tumor cells: Role of phenotypic plasticity and the metastatic microenvironment. SEMINARS IN CANCER BIOLOGY, 60, 138-147.Elsevier BV. doi: 10.1016/j.semcancer.2019.07.021.

Shurin, M.R., Morris, A., Wells, A., & Wheeler, S.E. (2020). Assessing Immune Response to SARS-CoV-2 Infection. Immunotargets Ther, 9, 111-114.Informa UK Limited. doi: 10.2147/ITT.S264138.

Swamynathan, S.K., & Wells, A. (2020). Conjunctival goblet cells: Ocular surface functions, disorders that affect them, and the potential for their regeneration. OCULAR SURFACE, 18(1), 19-26.Elsevier BV. doi: 10.1016/j.jtos.2019.11.005.

Swogger, J., Conner, I.P., Rosano, M., Kemmerer, M., Happ-Smith, C., Wells, A., Schuman, J.S., & Yates, C.C. (2020). Injected Versus Sponge-Applied Mitomycin C (MMC) During Modified Trabeculectomy in New Zealand White Rabbit Model. TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, 9(11), 23.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/tvst.9.11.23.

Sylakowski, K., Bradshaw, A., & Wells, A. (2020). Mesenchymal Stem Cell/Multipotent Stromal Cell Augmentation of Wound Healing Lessons from the Physiology of Matrix and Hypoxia Support. AMERICAN JOURNAL OF PATHOLOGY, 190(7), 1370-1381.Elsevier BV. doi: 10.1016/j.ajpath.2020.03.017.

Jiang, X., Wells, A., Brufsky, A., & Neapolitan, R. (2019). A clinical decision support system learned from data to personalize treatment recommendations towards preventing breast cancer metastasis. PLOS ONE, 14(3), e0213292.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0213292.

Jiang, Y., Wells, A., Sylakowski, K., Clark, A.M., & Ma, B. (2019). Adult Stem Cell Functioning in the Tumor Micro-Environment. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(10), 2566.MDPI AG. doi: 10.3390/ijms20102566.

Ma, B., Khazali, M., Shao, H., Jiang, Y., & Wells, A. (2019). Expression of E-cadherin and specific CXCR3 isoforms impact each other in prostate cancer. CELL COMMUNICATION AND SIGNALING, 17(1), 164.Springer Science and Business Media LLC. doi: 10.1186/s12964-019-0489-1.

Shao, H., Wingert, B., Weins, A., Pollak, M.R., Camacho, C., & Wells, A. (2019). Focal segmental glomerulosclerosis ACTN4 mutants binding to actin: regulation by phosphomimetic mutations. SCIENTIFIC REPORTS, 9(1), 15517.Springer Science and Business Media LLC. doi: 10.1038/s41598-019-51825-2.

Beckwitt, C.H., Brufsky, A., Oltvai, Z.N., & Wells, A. (2018). Statin drugs to reduce breast cancer recurrence and mortality. BREAST CANCER RESEARCH, 20(1), 144.Springer Science and Business Media LLC. doi: 10.1186/s13058-018-1066-z.

Beckwitt, C.H., Clark, A.M., Ma, B., Whaley, D., Oltvai, Z.N., & Wells, A. (2018). Statins attenuate outgrowth of breast cancer metastases. BRITISH JOURNAL OF CANCER, 119(9), 1094-1105.Springer Science and Business Media LLC. doi: 10.1038/s41416-018-0267-7.

Beckwitt, C.H., Clark, A.M., Wheeler, S., Taylor, D.L., Stolz, D.B., Griffith, L., & Wells, A. (2018). Liver 'organ on a chip'. EXPERIMENTAL CELL RESEARCH, 363(1), 15-25.Elsevier BV. doi: 10.1016/j.yexcr.2017.12.023.

Beckwitt, C.H., Shiraha, K., & Wells, A. (2018). Lipophilic statins limit cancer cell growth and survival, via involvement of Akt signaling. PLOS ONE, 13(5), e0197422.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0197422.

Bradshaw, A., Sylakowski, K., & Wells, A. (2018). The Pro-reparative Engine: Stem Cells Aid Healing by Dampening Inflammation. Curr Pathobiol Rep, 6(2), 109-115.Springer Science and Business Media LLC. doi: 10.1007/s40139-018-0167-9.

Clark, A.M., Kumar, M.P., Wheeler, S.E., Young, C.L., Venkataramanan, R., Stolz, D.B., Griffith, L.G., Lauffenburger, D.A., & Wells, A. (2018). A Model of Dormant-Emergent Metastatic Breast Cancer Progression Enabling Exploration of Biomarker Signatures. MOLECULAR & CELLULAR PROTEOMICS, 17(4), 619-630.Elsevier BV. doi: 10.1074/mcp.RA117.000370.

Ishikawa, T., Hosaka, Y.Z., Beckwitt, C., Wells, A., Oltvai, Z.N., & Warita, K. (2018). Concomitant attenuation of HMG-CoA reductase expression potentiates the cancer cell growth-inhibitory effect of statins and expands their efficacy in tumor cells with epithelial characteristics. Oncotarget, 9(50), 29304-29315.Impact Journals, LLC. doi: 10.18632/oncotarget.25448.

Khazali, A.S., Clark, A.M., & Wells, A. (2018). Inflammatory cytokine IL-8/CXCL8 promotes tumour escape from hepatocyte-induced dormancy. BRITISH JOURNAL OF CANCER, 118(4), 566-576.Springer Science and Business Media LLC. doi: 10.1038/bjc.2017.414.

Raghu, V.K., Beckwitt, C.H., Warita, K., Wells, A., Benos, P.V., & Oltvai, Z.N. (2018). Biomarker identification for statin sensitivity of cancer cell lines. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 495(1), 659-665.Elsevier BV. doi: 10.1016/j.bbrc.2017.11.065.

Stram, M.N., Suciu, C.N., Seheult, J.N., McCullough, M.A., Kader, M., Wells, A., Pasculle, A.W., Rinaldo, C.R., & Ismail, N. (2018). Herpes Simplex Virus-1 qPCR in the Diagnosis of Lower Respiratory Tract Infections in Organ Transplant Recipients and Critically Ill Patients. AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 150(6), 522-532.Oxford University Press (OUP). doi: 10.1093/AJCP/AQY088.

Wells, A., & Wiley, H.S. (2018). A systems perspective of heterocellular signaling. SYSTEMS BIOLOGY, 62(4), 607-617.Portland Press Ltd. doi: 10.1042/EBC20180015.

Wells, A., Clark, A., Bradshaw, A., Ma, B., & Edington, H. (2018). The great escape: How metastases of melanoma, and other carcinomas, avoid elimination. EXPERIMENTAL BIOLOGY AND MEDICINE, 243(17-18), 1245-1255.Frontiers Media SA. doi: 10.1177/1535370218820287.

Zeng, Z., Jiang, X., Li, X., Wells, A., Luo, Y., & Neapolitan, R. (2018). Conjugated equine estrogen and medroxyprogesterone acetate are associated with decreased risk of breast cancer relative to bioidentical hormone therapy and controls. PLOS ONE, 13(5), e0197064.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0197064.

Clark, A.M., Wheeler, S.E., Young, C.L., Stockdale, L., Neiman, J.S., Zhao, W., Stolz, D.B., Venkataramanan, R., Lauffenburger, D., Griffith, L., & Wells, A. (2017). A liver microphysiological system of tumor cell dormancy and inflammatory responsiveness is affected by scaffold properties. LAB ON A CHIP, 17(1), 156-168.Royal Society of Chemistry (RSC). doi: 10.1039/c6lc01171c.

Dioufa, N., Clark, A.M., Ma, B., Beckwitt, C.H., & Wells, A. (2017). Bi-directional exosome-driven intercommunication between the hepatic niche and cancer cells. MOLECULAR CANCER, 16(1), 172.Springer Science and Business Media LLC. doi: 10.1186/s12943-017-0740-6.

Gonzalez, A., Garcia de Durango, C., Alonso, V., Bravo, B., Rodriguez de Gortazar, A., Wells, A., Forteza, J., & Vidal-Vanaclocha, F. (2017). Distinct Osteomimetic Response of Androgen-Dependent and Independent Human Prostate Cancer Cells to Mechanical Action of Fluid Flow: Prometastatic Implications. PROSTATE, 77(3), 321-333.Wiley. doi: 10.1002/pros.23270.

Kader, M., Alaoui-EL-Azher, M., Vorhauer, J., Kode, B.B., Wells, J.Z., Stolz, D., Michalopoulos, G., Wells, A., Scott, M., & Ismail, N. (2017). MyD88-dependent inflammasome activation and autophagy inhibition contributes to Ehrlichia-induced liver injury and toxic shock. PLOS PATHOGENS, 13(10), e1006644.Public Library of Science (PLoS). doi: 10.1371/journal.ppat.1006644.

Khazali, A.S., Clark, A.M., & Wells, A. (2017). A Pathway to Personalizing Therapy for Metastases Using Liver-on-a-Chip Platforms. STEM CELL REVIEWS AND REPORTS, 13(3), 364-380.Springer Science and Business Media LLC. doi: 10.1007/s12015-017-9735-3.

Shao, H., Lauffenburger, D., & Wells, A. (2017). Tyro3 carboxyl terminal region confers stability and contains the autophosphorylation sites. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 490(3), 1074-1079.Elsevier BV. doi: 10.1016/j.bbrc.2017.06.168.

Wells, A., & Ma, B. (2017). Friend turned foe: E-cadherin perversely protects micrometastases. TRANSLATIONAL ANDROLOGY AND UROLOGY, 6(2), 338-340.AME Publishing Company. doi: 10.21037/tau.2017.03.25.

Yates, C.C., Nuschke, A., Rodrigues, M., Whaley, D., Dechant, J.J., Taylor, D.P., & Wells, A. (2017). Improved Transplanted Stem Cell Survival in a Polymer Gel Supplemented With Tenascin C Accelerates Healing and Reduces Scarring of Murine Skin Wounds. CELL TRANSPLANTATION, 26(1), 103-113.SAGE Publications. doi: 10.3727/096368916X692249.

Yates, C.C., Rodrigues, M., Nuschke, A., Johnson, Z.I., Whaley, D., Stolz, D., Newsome, J., & Wells, A. (2017). Multipotent stromal cells/mesenchymal stem cells and fibroblasts combine to minimize skin hypertrophic scarring. STEM CELL RESEARCH & THERAPY, 8(1), 193.Springer Science and Business Media LLC. doi: 10.1186/s13287-017-0644-9.

Bodnar, R.J., Satish, L., Yates, C.C., & Wells, A. (2016). Pericytes: A newly recognized player in wound healing. WOUND REPAIR AND REGENERATION, 24(2), 204-214.Wiley. doi: 10.1111/wrr.12415.

Clark, A.M., Ma, B., Taylor, D.L., Griffith, L., & Wells, A. (2016). Liver metastases: Microenvironments and ex-vivo models. EXPERIMENTAL BIOLOGY AND MEDICINE, 241(15), 1639-1652.Frontiers Media SA. doi: 10.1177/1535370216658144.

Gordonov, S., Hwang, M.K., Wells, A., Gertler, F.B., Lauffenburger, D.A., & Bathe, M. (2016). Time series modeling of live-cell shape dynamics for image-based phenotypic profiling. INTEGRATIVE BIOLOGY, 8(1), 73-90.Oxford University Press (OUP). doi: 10.1039/c5ib00283d.

Huen, A.C., Marathi, A., Nam, P.K., & Wells, A. (2016). CXCL11 Expression by Keratinocytes Occurs Transiently Between Reaching Confluence and Cellular Compaction. ADVANCES IN WOUND CARE, 5(12), 517-526.Mary Ann Liebert Inc. doi: 10.1089/wound.2015.0680.

Ma, B., Wheeler, S.E., Clark, A.M., Whaley, D.L., Yang, M., & Wells, A. (2016). Liver protects metastatic prostate cancer from induced death by activating E-cadherin signaling. HEPATOLOGY, 64(5), 1725-1742.Ovid Technologies (Wolters Kluwer Health). doi: 10.1002/hep.28755.

Nuschke, A., Rodrigues, M., Rivera, J., Yates, C., Whaley, D., Stolz, D., Griffith, L., & Wells, A. (2016). Epidermal Growth Factor Tethered to β-Tricalcium Phosphate Bone Scaffolds via a High-Affinity Binding Peptide Enhances Survival of Human Mesenchymal Stem Cells/Multipotent Stromal Cells in an Immune-Competent Parafascial Implantation Assay in Mice. STEM CELLS TRANSLATIONAL MEDICINE, 5(11), 1580-1586.Oxford University Press (OUP). doi: 10.5966/sctm.2015-0326.

Nuschke, A., Rodrigues, M., Wells, A.W., Sylakowski, K., & Wells, A. (2016). Mesenchymal stem cells/multipotent stromal cells (MSCs) are glycolytic and thus glucose is a limiting factor of in vitro models of MSC starvation. STEM CELL RESEARCH & THERAPY, 7(1), 179.Springer Science and Business Media LLC. doi: 10.1186/s13287-016-0436-7.

Wells, A., Nuschke, A., & Yates, C.C. (2016). Skin tissue repair: Matrix microenvironmental influences. MATRIX BIOLOGY, 49, 25-36.Elsevier BV. doi: 10.1016/j.matbio.2015.08.001.

Yang, M., Ma, B., Shao, H., Clark, A.M., & Wells, A. (2016). Macrophage phenotypic subtypes diametrically regulate epithelial-mesenchymal plasticity in breast cancer cells. BMC CANCER, 16(1), 419.Springer Science and Business Media LLC. doi: 10.1186/s12885-016-2411-1.

Bodnar, R.J., & Wells, A. (2015). Differential regulation of pericyte function by the CXC receptor 3. WOUND REPAIR AND REGENERATION, 23(6), 785-796.Wiley. doi: 10.1111/wrr.12346.

Furukawa, M., Wheeler, S., Clark, A.M., & Wells, A. (2015). Lung Epithelial Cells Induce Both Phenotype Alteration and Senescence in Breast Cancer Cells. In Samant, R. (Ed.). PLOS ONE, 10(1), e0118060.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0118060.

Ma, B., Khazali, A., & Wells, A. (2015). CXCR3 in carcinoma progression. HISTOLOGY AND HISTOPATHOLOGY, 30(7), 781-792. doi: 10.14670/HH-11-594.

Richard, S., Wells, A., Connor, J., & Price, F. (2015). Use of ChemoFx® for Identification of Effective Treatments in Epithelial Ovarian Cancer. PLoS Curr, 7(EVIDENCEONGENOMICTESTS).Public Library of Science (PLoS). doi: 10.1371/currents.eogt.8b0b6fffc7b999b34bc4c8152edbf237.

Shao, H., Kirkwood, J.M., & Wells, A. (2015). Tenascin-C Signaling in melanoma. CELL ADHESION & MIGRATION, 9(1-2), 125-130.Informa UK Limited. doi: 10.4161/19336918.2014.972781.

Travers, T., Shao, H., Joughin, B.A., Lauffenburger, D.A., Wells, A., & Camacho, C.J. (2015). Tandem phosphorylation within an intrinsically disordered region regulates ACTN4 function. SCIENCE SIGNALING, 8(378), ra51.American Association for the Advancement of Science (AAAS). doi: 10.1126/scisignal.aaa1977.

Clark, A.M., Wheeler, S.E., Taylor, D.P., Pillai, V.C., Young, C.L., Prantil-Baun, R., Nguyen, T., Stolz, D.B., Borenstein, J.T., Lauffenburger, D.A., Venkataramanan, R., Griffith, L.G., & Wells, A. (2014). A microphysiological system model of therapy for liver micrometastases. EXPERIMENTAL BIOLOGY AND MEDICINE, 239(9), 1170-1179.Frontiers Media SA. doi: 10.1177/1535370214532596.

Ding, Z., Joy, M., Bhargava, R., Gunsaulus, M., Lakshman, N., Miron-Mendoza, M., Petroll, M., Condeelis, J., Wells, A., & Roy, P. (2014). Profilin-1 downregulation has contrasting effects on early vs late steps of breast cancer metastasis. ONCOGENE, 33(16), 2065-2074.Springer Science and Business Media LLC. doi: 10.1038/onc.2013.166.

Grahovac, J., & Wells, A. (2014). Matrikine and matricellular regulators of EGF receptor signaling on cancer cell migration and invasion. LABORATORY INVESTIGATION, 94(1), 31-40.Elsevier BV. doi: 10.1038/labinvest.2013.132.

Griffith, L.G., Wells, A., & Stolz, D.B. (2014). Engineering Liver. HEPATOLOGY, 60(4), 1426-1434.Ovid Technologies (Wolters Kluwer Health). doi: 10.1002/hep.27150.

Jamison, J., Wang, J.H.C., & Wells, A. (2014). PKCδ Regulates Force Signaling during VEGF/CXCL4 Induced Dissociation of Endothelial Tubes. In Hotchin, N.A. (Ed.). PLOS ONE, 9(4), e93968.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0093968.

Ma, B., & Wells, A. (2014). The Mitogen-activated Protein ( MAP) Kinases p38 and Extracellular Signal-regulated Kinase ( ERK) Are Involved in Hepatocyte-mediated Phenotypic Switching in Prostate Cancer Cells. JOURNAL OF BIOLOGICAL CHEMISTRY, 289(16), 11153-11161.Elsevier BV. doi: 10.1074/jbc.M113.540237.

Nuschke, A., Rodrigues, M., Stolz, D.B., Chu, C.T., Griffith, L., & Wells, A. (2014). Human mesenchymal stem cells/multipotent stromal cells consume accumulated autophagosomes early in differentiation. STEM CELL RESEARCH & THERAPY, 5(6), 140.Springer Science and Business Media LLC. doi: 10.1186/scrt530.

Shao, H., Li, S., Watkins, S.C., & Wells, A. (2014). α-Actinin-4 Is Required for Amoeboid-type Invasiveness of Melanoma Cells. JOURNAL OF BIOLOGICAL CHEMISTRY, 289(47), 32717-32728.Elsevier BV. doi: 10.1074/jbc.M114.579185.

Taylor, D.P., Clark, A., Wheeler, S., & Wells, A. (2014). Hepatic nonparenchymal cells drive metastatic breast cancer outgrowth and partial epithelial to mesenchymal transition. BREAST CANCER RESEARCH AND TREATMENT, 144(3), 551-560.Springer Science and Business Media LLC. doi: 10.1007/s10549-014-2875-0.

Warita, K., Warita, T., Beckwitt, C.H., Schurdak, M.E., Vazquez, A., Wells, A., & Oltvai, Z.N. (2014). Statin-induced mevalonate pathway inhibition attenuates the growth of mesenchymal-like cancer cells that lack functional E-cadherin mediated cell cohesion. SCIENTIFIC REPORTS, 4(1), 7593.Springer Science and Business Media LLC. doi: 10.1038/srep07593.

Wheeler, S.E., Clark, A.M., Taylor, D.P., Young, C.L., Pillai, V.C., Stolz, D.B., Venkataramanan, R., Lauffenburger, D., Griffith, L., & Wells, A. (2014). Spontaneous dormancy of metastatic breast cancer cells in an all human liver microphysiologic system. BRITISH JOURNAL OF CANCER, 111(12), 2342-2350.Springer Science and Business Media LLC. doi: 10.1038/bjc.2014.533.

Bodnar, R.J., Rodgers, M.E., Chen, W.C.W., & Wells, A. (2013). Pericyte Regulation of Vascular Remodeling Through the CXC Receptor 3. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 33(12), 2818-2829.Ovid Technologies (Wolters Kluwer Health). doi: 10.1161/ATVBAHA.113.302012.

Grahovac, J., Becker, D., & Wells, A. (2013). Melanoma Cell Invasiveness Is Promoted at Least in Part by the Epidermal Growth Factor-Like Repeats of Tenascin-C. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 133(1), 210-220.Elsevier BV. doi: 10.1038/jid.2012.263.

Hang, T.C., Tedford, N.C., Reddy, R.J., Rimchala, T., Wells, A., White, F.M., Kamm, R.D., & Lauffenburger, D.A. (2013). Vascular Endothelial Growth Factor (VEGF) and Platelet (PF-4) Factor 4 Inputs Modulate Human Microvascular Endothelial Signaling in a Three-Dimensional Matrix Migration Context. MOLECULAR & CELLULAR PROTEOMICS, 12(12), 3704-3718.Elsevier BV. doi: 10.1074/mcp.M113.030528.

Jamison, J., Lauffenburger, D., Wang, J.C.H., & Wells, A. (2013). PKCδ Localization at the Membrane Increases Matrix Traction Force Dependent on PLCγ1/EGFR Signaling. PLOS ONE, 8(10), e77434.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0077434.

Rodrigues, M., Blair, H., Stockdale, L., Griffith, L., & Wells, A. (2013). Surface Tethered Epidermal Growth Factor Protects Proliferating and Differentiating Multipotential Stromal Cells from FasL-Induced Apoptosis. STEM CELLS, 31(1), 104-116.Oxford University Press (OUP). doi: 10.1002/stem.1215.

Rodrigues, M., Yates, C.C., Nuschke, A., Griffith, L., & Wells, A. (2013). The Matrikine Tenascin-C Protects Multipotential Stromal Cells/Mesenchymal Stem Cells from Death Cytokines Such as FasL. TISSUE ENGINEERING PART A, 19(17-18), 1972-1983.Mary Ann Liebert Inc. doi: 10.1089/ten.tea.2012.0568.

Shao, H., Travers, T., Camacho, C.J., & Wells, A. (2013). The carboxyl tail of alpha-actinin-4 regulates its susceptibility to m-calpain and thus functions in cell migration and spreading. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 45(6), 1051-1063.Elsevier BV. doi: 10.1016/j.biocel.2013.02.015.

Taylor, D.P., Wells, J.Z., Savol, A., Chennubhotla, C., & Wells, A. (2013). Modeling Boundary Conditions for Balanced Proliferation in Metastatic Latency. CLINICAL CANCER RESEARCH, 19(5), 1063-1070.American Association for Cancer Research (AACR). doi: 10.1158/1078-0432.CCR-12-3180.

Travers, T., Shao, H., Wells, A., & Camacho, C.J. (2013). Modeling the Assembly of the Multiple Domains of α-actinin-4 and Its Role in Actin Cross-linking. BIOPHYSICAL JOURNAL, 104(3), 705-715.Elsevier BV. doi: 10.1016/j.bpj.2012.12.003.

Wells, A., Grahovac, J., Wheeler, S., Ma, B., & Lauffenburger, D. (2013). Targeting tumor cell motility as a strategy against invasion and metastasis. TRENDS IN PHARMACOLOGICAL SCIENCES, 34(5), 283-289.Elsevier BV. doi: 10.1016/j.tips.2013.03.001.

Wells, A., Griffith, L., Wells, J.Z., & Taylor, D.P. (2013). The Dormancy Dilemma: Quiescence versus Balanced Proliferation. CANCER RESEARCH, 73(13), 3811-3816.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-13-0356.

Wheeler, S.E., Borenstein, J.T., Clark, A.M., Ebrahimkhani, M., Fox, I.J., Griffith, L., Inman, W., Lauffenburger, D., Nguyen, T., Pillai, V.C., Prantil-Baun, R., Stolz, D.B., Taylor, D., Ulrich, T., Venkataramanan, R., Wells, A., & Young, C. (2013). All-human microphysical model of metastasis therapy. STEM CELL RESEARCH & THERAPY, 4(Suppl 1), S11.Springer Science and Business Media LLC. doi: 10.1186/scrt372.

Chao, Y., Wu, Q., Acquafondata, M., Dhir, R., & Wells, A. (2012). Partial mesenchymal to epithelial reverting transition in breast and prostate cancer metastases. Cancer Microenviron, 5(1), 19-28.Springer Science and Business Media LLC. doi: 10.1007/s12307-011-0085-4.

Chao, Y., Wu, Q., Shepard, C., & Wells, A. (2012). Hepatocyte induced re-expression of E-cadherin in breast and prostate cancer cells increases chemoresistance. CLINICAL & EXPERIMENTAL METASTASIS, 29(1), 39-50.Springer Science and Business Media LLC. doi: 10.1007/s10585-011-9427-3.

Gunasinghe, N.P.A.D., Wells, A., Thompson, E.W., & Hugo, H.J. (2012). Mesenchymal-epithelial transition (MET) as a mechanism for metastatic colonisation in breast cancer. CANCER AND METASTASIS REVIEWS, 31(3-4), 469-478.Springer Science and Business Media LLC. doi: 10.1007/s10555-012-9377-5.

Jones, J., Wang, H., Zhou, J., Hardy, S., Turner, T., Austin, D., He, Q., Wells, A., Grizzle, W.E., & Yates, C. (2012). Nuclear Kaiso Indicates Aggressive Prostate Cancers and Promotes Migration and Invasiveness of Prostate Cancer Cells. AMERICAN JOURNAL OF PATHOLOGY, 181(5), 1836-1846.Elsevier BV. doi: 10.1016/j.ajpath.2012.08.008.

Meyer, A.S., Hughes-Alford, S.K., Kay, J.E., Castillo, A., Wells, A., Gertler, F.B., & Lauffenburger, D.A. (2012). 2D protrusion but not motility predicts growth factor-induced cancer cell migration in 3D collagen. JOURNAL OF CELL BIOLOGY, 197(6), 721-729.Rockefeller University Press. doi: 10.1083/jcb.201201003.

Park, S., Pantanowitz, L., Parwani, A.V., Wells, A., & Oltvai, Z.N. (2012). Workflow Organization in Pathology. CLINICS IN LABORATORY MEDICINE, 32(4), 601-+.Elsevier BV. doi: 10.1016/j.cll.2012.07.008.

Rodrigues, M., Turner, O., Stolz, D., Griffith, L.G., & Wells, A. (2012). Production of Reactive Oxygen Species by Multipotent Stromal Cells/Mesenchymal Stem Cells Upon Exposure to Fas Ligand. CELL TRANSPLANTATION, 21(10), 2171-2187.SAGE Publications. doi: 10.3727/096368912X639035.

Wells, A. (2012). Laboratory medicine: a view to the future of diagnostics and training. Rinsho Byori, 60(4), 312-320.

Wells, A., & Oltvai, Z.N. (2012). Conceptual Advances in Pathology Preface. CLINICS IN LABORATORY MEDICINE, 32(4), IX-X.Elsevier BV. doi: 10.1016/j.cll.2012.07.007.

Wu, Q., Dhir, R., & Wells, A. (2012). Altered CXCR3 isoform expression regulates prostate cancer cell migration and invasion. MOLECULAR CANCER, 11(1), 3.Springer Science and Business Media LLC. doi: 10.1186/1476-4598-11-3.

Yates, C.C., Hebda, P., & Wells, A. (2012). Skin Wound Healing and Scarring: Fetal Wounds and Regenerative Restitution. BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS, 96(4), 325-333.Wiley. doi: 10.1002/bdrc.21024.

Yates, C.C., Whaley, D., & Wells, A. (2012). Transplanted Fibroblasts Prevents Dysfunctional Repair in a Murine CXCR3-Deficient Scarring Model. CELL TRANSPLANTATION, 21(5), 919-931.SAGE Publications. doi: 10.3727/096368911X623817.

Yates-Binder, C.C., Rodgers, M., Jaynes, J., Wells, A., Bodnar, R.J., & Turner, T. (2012). An IP-10 (CXCL10)-Derived Peptide Inhibits Angiogenesis. In Proost, P. (Ed.). PLOS ONE, 7(7), e40812.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0040812.

Kim, H.D., Meyer, A.S., Wagner, J.P., Alford, S.K., Wells, A., Gertler, F.B., & Lauffenburger, D.A. (2011). Signaling Network State Predicts Twist-Mediated Effects on Breast Cell Migration Across Diverse Growth Factor Contexts. MOLECULAR & CELLULAR PROTEOMICS, 10(11), M111.008433.Elsevier BV. doi: 10.1074/mcp.M111.008433.

Leloup, L., & Wells, A. (2011). Calpains as potential anti-cancer targets. EXPERT OPINION ON THERAPEUTIC TARGETS, 15(3), 309-323.Informa UK Limited. doi: 10.1517/14728222.2011.553611.

Meran, S., Luo, D.D., Simpson, R., Martin, J., Wells, A., Steadman, R., & Phillips, A.O. (2011). Hyaluronan Facilitates Transforming Growth Factor-β1-dependent Proliferation via CD44 and Epidermal Growth Factor Receptor Interaction. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(20), 17618-17630.Elsevier BV. doi: 10.1074/jbc.M111.226563.

Wells, A., Chao, Y.L., Grahovac, J., Wu, Q., & Lauffenburger, D.A. (2011). Epithelial and mesenchymal phenotypic switchings modulate cell motility in metastasis. FRONTIERS IN BIOSCIENCE-LANDMARK, 16(3), 815-837.IMR Press. doi: 10.2741/3722.

Wu, S., Wells, A., Griffith, L.G., & Lauffenburger, D.A. (2011). Controlling multipotent stromal cell migration by integrating "course-graining" materials and "fine-tuning" small molecules via decision tree signal-response modeling. BIOMATERIALS, 32(30), 7524-7531.Elsevier BV. doi: 10.1016/j.biomaterials.2011.06.050.

Yates, C.C., Bodnar, R., & Wells, A. (2011). Matrix control of scarring. CELLULAR AND MOLECULAR LIFE SCIENCES, 68(11), 1871-1881.Springer Science and Business Media LLC. doi: 10.1007/s00018-011-0663-0.

Bae, Y.H., Ding, Z., Das, T., Wells, A., Gertler, F., & Roy, P. (2010). Profilin1 regulates PI(3,4)P2 and lamellipodin accumulation at the leading edge thus influencing motility of MDA-MB-231 cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(50), 21547-21552.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1002309107.

Chao, Y.L., Shepard, C.R., & Wells, A. (2010). Breast carcinoma cells re-express E-cadherin during mesenchymal to epithelial reverting transition. MOLECULAR CANCER, 9(1), 179.Springer Science and Business Media LLC. doi: 10.1186/1476-4598-9-179.

Hood, B.L., Grahovac, J., Flint, M.S., Sun, M., Charro, N., Becker, D., Wells, A., & Conrads, T.P. (2010). Proteomic Analysis of Laser Microdissected Melanoma Cells from Skin Organ Cultures. JOURNAL OF PROTEOME RESEARCH, 9(7), 3656-3663.American Chemical Society (ACS). doi: 10.1021/pr100164x.

Krishna, P., Regner, M., Palko, J., Liu, F., Abramowitch, S., Jiang, J., & Wells, A. (2010). The Effects of Decorin and HGF-Primed Vocal Fold Fibroblasts In Vitro and Ex Vivo in a Porcine Model of Vocal Fold Scarring. LARYNGOSCOPE, 120(11), 2247-2257.Wiley. doi: 10.1002/lary.21087.

Leloup, L., Shao, H., Bae, Y.H., Deasy, B., Stolz, D., Roy, P., & Wells, A. (2010). m-calpain Activation Is Regulated by Its Membrane Localization and by Its Binding to Phosphatidylinositol 4,5-Bisphosphate. JOURNAL OF BIOLOGICAL CHEMISTRY, 285(43), 33549-33566.Elsevier BV. doi: 10.1074/jbc.M110.123604.

Li, M., Aliotta, J.M., Asara, J.M., Wu, Q., Dooner, M.S., Tucker, L.D., Wells, A., Quesenberry, P.J., & Ramratnam, B. (2010). Intercellular Transfer of Proteins as Identified by Stable Isotope Labeling of Amino Acids in Cell Culture. JOURNAL OF BIOLOGICAL CHEMISTRY, 285(9), 6285-6297.Elsevier BV. doi: 10.1074/jbc.M109.057943.

Rodrigues, M., Griffith, L.G., & Wells, A. (2010). Growth factor regulation of proliferation and survival of multipotential stromal cells. STEM CELL RESEARCH & THERAPY, 1(4), 32.Springer Science and Business Media LLC. doi: 10.1186/scrt32.

Shao, H., Wang, J.H.C., Pollak, M.R., & Wells, A. (2010). α-Actinin-4 Is Essential for Maintaining the Spreading, Motility and Contractility of Fibroblasts. In Hotchin, N.A. (Ed.). PLOS ONE, 5(11), e13921.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0013921.

Shao, H., Wu, C., & Wells, A. (2010). Phosphorylation of α-Actinin 4 upon Epidermal Growth Factor Exposure Regulates Its Interaction with Actin. JOURNAL OF BIOLOGICAL CHEMISTRY, 285(4), 2591-2600.Elsevier BV. doi: 10.1074/jbc.M109.035790.

Silver, K., Leloup, L., Freeman, L.C., Wells, A., & Lillich, J.D. (2010). Non-steroidal anti-inflammatory drugs inhibit calpain activity and membrane localization of calpain 2 protease. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 42(12), 2030-2036.Elsevier BV. doi: 10.1016/j.biocel.2010.09.007.

Simpson, R.M.L., Wells, A., Thomas, D., Stephens, P., Steadman, R., & Phillips, A. (2010). Aging Fibroblasts Resist Phenotypic Maturation Because of Impaired Hyaluronan-Dependent CD44/Epidermal Growth Factor Receptor Signaling. AMERICAN JOURNAL OF PATHOLOGY, 176(3), 1215-1228.Elsevier BV. doi: 10.2353/ajpath.2010.090802.

Tamama, K., Kawasaki, H., & Wells, A. (2010). Epidermal Growth Factor (EGF) Treatment on Multipotential Stromal Cells (MSCs). Possible Enhancement of Therapeutic Potential of MSC. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2010, 795385.Hindawi Limited. doi: 10.1155/2010/795385.

Wells, A. (2010). Genetics of Neurologic and Psychiatric Diseases Preface. CLINICS IN LABORATORY MEDICINE, 30(4), XIII-XIV.Elsevier BV. doi: 10.1016/j.cll.2010.07.012.

Wells, A., & Leloup, L. (2010). Calpain. In Handbook of Cell Signaling. 2, (pp. 999-1008).Elsevier. doi: 10.1016/b978-0-12-374145-5.00126-1.

Yates, C.C., Krishna, P., Whaley, D., Bodnar, R., Turner, T., & Wells, A. (2010). Lack of CXC Chemokine Receptor 3 Signaling Leads to Hypertrophic and Hypercellular Scarring. AMERICAN JOURNAL OF PATHOLOGY, 176(4), 1743-1755.Elsevier BV. doi: 10.2353/ajpath.2010.090564.

Bae, Y.H., Ding, Z., Zou, L., Wells, A., Gertler, F., & Roy, P. (2009). Loss of Profilin-1 Expression Enhances Breast Cancer Cell Motility by Ena/VASP Proteins. JOURNAL OF CELLULAR PHYSIOLOGY, 219(2), 354-364.Wiley. doi: 10.1002/jcp.21677.

Bodnar, R.J., Yates, C.C., Rodgers, M.E., Du, X., & Wells, A. (2009). IP-10 induces dissociation of newly formed blood vessels. JOURNAL OF CELL SCIENCE, 122(12), 2064-2077.The Company of Biologists. doi: 10.1242/jcs.048793.

Das, T., Bae, Y.H., Wells, A., & Roy, P. (2009). Profilin-1 Overexpression Upregulates PTEN and Suppresses AKT Activation in Breast Cancer Cells. JOURNAL OF CELLULAR PHYSIOLOGY, 218(2), 436-443.Wiley. doi: 10.1002/jcp.21618.

Ding, Z., Gaua, D., Deasy, B., Wells, A., & Roy, P. (2009). Both actin and polyproline interactions of profilin-1 are required for migration, invasion and capillary morphogenesis of vascular endothelial cells. EXPERIMENTAL CELL RESEARCH, 315(17), 2963-2973.Elsevier BV. doi: 10.1016/j.yexcr.2009.07.004.

Marcantonio, N.A., Boehm, C.A., Rozic, R.J., Au, A., Wells, A., Muschler, G.F., & Griffith, L.G. (2009). The influence of tethered epidermal growth factor on connective tissue progenitor colony formation. BIOMATERIALS, 30(27), 4629-4638.Elsevier BV. doi: 10.1016/j.biomaterials.2009.05.061.

Platt, M.O., Roman, A.J., Wells, A., Lauffenburger, D.A., & Griffith, L.G. (2009). Sustained Epidermal Growth Factor Receptor Levels and Activation by Tethered Ligand Binding Enhances Osteogenic Differentiation of Multi-Potent Marrow Stromal Cells. JOURNAL OF CELLULAR PHYSIOLOGY, 221(2), 306-317.Wiley. doi: 10.1002/jcp.21854.

Platt, M.O., Wilder, C.L., Wells, A., Griffith, L.G., & Lauffenburger, D.A. (2009). Multipathway Kinase Signatures of Multipotent Stromal Cells are Predictive for Osteogenic Differentiation. STEM CELLS, 27(11), 2804-2814.Oxford University Press (OUP). doi: 10.1002/stem.215.

Yates, C.C., Whaley, D., Hooda, S., Hebda, P.A., Bodnar, R.J., & Wells, A. (2009). Delayed reepithelialization and basement membrane regeneration after wounding in mice lacking CXCR3. WOUND REPAIR AND REGENERATION, 17(1), 34-41.Wiley. doi: 10.1111/j.1524-475X.2008.00439.x.

Iyer, A.K.V., Tran, K.T., Griffith, L., & Wells, A. (2008). Cell surface restriction of EGFR by a tenascin cytotactin-encoded EGF-like repeat is preferential for motility-related signaling. JOURNAL OF CELLULAR PHYSIOLOGY, 214(2), 504-512.Wiley. doi: 10.1002/jcp.21232.

Kim, H.D., Guo, T.W., Wu, A.P., Wells, A., Gertler, F.B., & Lauffenburger, D.A. (2008). Epidermal Growth Factor-induced Enhancement of Glioblastoma Cell Migration in 3D Arises from an Intrinsic Increase in Speed But an Extrinsic Matrix- and Proteolysis-dependent Increase in Persistence. MOLECULAR BIOLOGY OF THE CELL, 19(10), 4249-4259.American Society for Cell Biology (ASCB). doi: 10.1091/mbc.E08-05-0501.

Mi, Z., Holmes, F.A., Hellerstedt, B., Pippen, J., Collea, R., Backner, A., Bush, J.E., Gallion, H.H., Wells, A., & O'Shaughnessy, J.A. (2008). Feasibility assessment of a chemoresponse assay to predict pathologic response in neoadjuvant chemotherapy for breast cancer patients. Anticancer Research, 28(3 B), 1733-1740.

Nozawa, H., Howell, G., Suzuki, S., Zhang, Q., Qi, Y., Klein-Seetharaman, J., Wells, A., Grandis, J.R., & Thomas, S.M. (2008). Combined inhibition of PLCγ-1 and c-Src abrogates epidermal growth factor receptor-mediated head and neck squamous cell carcinoma invasion. CLINICAL CANCER RESEARCH, 14(13), 4336-4344.American Association for Cancer Research (AACR). doi: 10.1158/1078-0432.CCR-07-4857.

Shao, H., Yi, X.M., & Wells, A. (2008). Epidermal growth factor protects fibroblasts from apoptosis via PI3 kinase and Rac signaling pathways. WOUND REPAIR AND REGENERATION, 16(4), 551-558.Wiley. doi: 10.1111/j.1524-475X.2008.00402.x.

Sharrow, A.C., li, Y., Micsenyi, A., Griswold, R.D., Wells, A., Monga, S.S.P., & Blair, H.C. (2008). Modulation of osteoblast gap junction connectivity by serum, TNFα, and TRAIL. EXPERIMENTAL CELL RESEARCH, 314(2), 297-308.Elsevier BV. doi: 10.1016/j.yexcr.2007.10.010.

Tamama, K., Sen, C.K., & Wells, A. (2008). Differentiation of Bone Marrow Mesenchymal Stem Cells into the Smooth Muscle Lineage by Blocking ERK/MAPK Signaling Pathway. STEM CELLS AND DEVELOPMENT, 17(5), 897-908.Mary Ann Liebert Inc. doi: 10.1089/scd.2007.0155.

Wells, A., Yates, C., & Shepard, C.R. (2008). E-cadherin as an indicator of mesenchymal to epithelial reverting transitions during the metastatic seeding of disseminated carcinomas. CLINICAL & EXPERIMENTAL METASTASIS, 25(6), 621-628.Springer Science and Business Media LLC. doi: 10.1007/s10585-008-9167-1.

Yates, C.C., Whaley, D., Y-Chen, A., Kulesekaran, P., Hebda, P.A., & Wells, A. (2008). ELR-negative CXC chemokine CXCL11 (IP-9/I-TAC) facilitates dermal and epidermal maturation during wound repair. AMERICAN JOURNAL OF PATHOLOGY, 173(3), 643-652.Elsevier BV. doi: 10.2353/ajpath.2008.070990.

Blair, H.C., Wells, A., & Isales, C.M. (2007). Pituitary glycoprotein hormone receptors in non-endocrine organs. TRENDS IN ENDOCRINOLOGY AND METABOLISM, 18(6), 227-233.Elsevier BV. doi: 10.1016/j.tem.2007.06.001.

Fan, V.H., Au, A., Tamama, K., Littrell, R., Richardson, L.B., Wright, J.W., Wells, A., & Griffith, L.G. (2007). Tethered epidermal growth factor provides a survival advantage to mesenchymal stem cells. STEM CELLS, 25(5), 1241-1251.Oxford University Press (OUP). doi: 10.1634/stemcells.2006-0320.

Iyer, A.K.V., Tran, K.T., Borysenko, C.W., Cascio, M., Camacho, C.J., Blair, H.C., Bahar, I., & Wells, A. (2007). Tenascin cytotactin epidermal growth factor-like repeat binds epidermal growth factor receptor with low affinity. JOURNAL OF CELLULAR PHYSIOLOGY, 211(3), 748-758.Wiley. doi: 10.1002/jcp.20986.

Joslin, E.J., Opresko, L.K., Wells, A., Wiley, H.S., & Lauffenburger, D.A. (2007). EGF-receptor-mediated mammary epithelial cell migration is driven by sustained ERK signaling from autocrine stimulation. JOURNAL OF CELL SCIENCE, 120(20), 3688-3699.The Company of Biologists. doi: 10.1242/jcs.010488.

Kharait, S., Hautaniemi, S., Wu, S., Iwabu, A., Lauffenburger, D.A., & Wells, A. (2007). Decision tree modeling predicts effects of inhibiting contractility signaling on cell motility. BMC SYSTEMS BIOLOGY, 1(1), 9.Springer Science and Business Media LLC. doi: 10.1186/1752-0509-1-9.

Shepard, C.R., Kassis, J., Whaley, D.L., Kim, H.G., & Wells, A. (2007). PLCγ contributes to metastasis of in situ-occurring mammary and prostate tumors. ONCOGENE, 26(21), 3020-3026.Springer Science and Business Media LLC. doi: 10.1038/sj.onc.1210115.

Wells, A. (2007). Calpain. In xPharm: The Comprehensive Pharmacology Reference. (pp. 1-8).Elsevier. doi: 10.1016/b978-008055232-3.60557-4.

Wells, A., & Smith, B.R. (2007). The goals of resident training in laboratory medicine in combined anatomic pathology/clinical pathology programs: An overview. CLINICS IN LABORATORY MEDICINE, 27(2), 229-+.Elsevier BV. doi: 10.1016/j.cll.2007.03.001.

Yaroslavskiy, B.B., Sharrow, A.C., Wells, A., Robinson, L.J., & Blair, H.C. (2007). Necessity of inositol (1,4,5)-trisphosphate receptor 1 and μ-calpain in NO-induced osteoclast motility. JOURNAL OF CELL SCIENCE, 120(16), 2884-2894.The Company of Biologists. doi: 10.1242/jcs.004184.

Yates, C., Shepard, C.R., Papworth, G., Dash, A., Stolz, D.B., Tannenbaum, S., Griffith, L., & Wells, A. (2007). Novel three-dimensional organotypic liver bioreactor to directly visualize early events in metastatic progression. ADVANCES IN CANCER RESEARCH, VOL 97, 97, 225-+.Elsevier. doi: 10.1016/S0065-230X(06)97010-9.

Yates, C.C., Shepard, C.R., Stolz, D.B., & Wells, A. (2007). Co-culturing human prostate carcinoma cells with hepatocytes leads to increased expression of E-cadherin. BRITISH JOURNAL OF CANCER, 96(8), 1246-1252.Springer Science and Business Media LLC. doi: 10.1038/sj.bjc.6603700.

Yates, C.C., Whaley, D., Babu, R., Zhang, J., Krishna, P., Beckman, E., Pasculle, A.W., & Wells, A. (2007). The effect of multifunctional polymer-based gels on wound healing in full thickness bacteria-contaminated mouse skin wound models. BIOMATERIALS, 28(27), 3977-3986.Elsevier BV. doi: 10.1016/j.biomaterials.2007.05.008.

Yates, C.C., Whaley, D., Kulasekeran, P., Hancock, W.W., Lu, B., Bodnar, R., Newsome, J., Hebda, P.A., & Wells, A. (2007). Delayed and deficient dermal maturation in mice lacking the CXCR3 ELR-negative CXC chemokine receptor. AMERICAN JOURNAL OF PATHOLOGY, 171(2), 484-495.Elsevier BV. doi: 10.2353/ajpath.2007.061092.

Zou, L., Jaramillo, M., Whaley, D., Wells, A., Panchapakesa, V., Das, T., & Roy, P. (2007). Profilin-1 is a negative regulator of mammary carcinoma aggressiveness. BRITISH JOURNAL OF CANCER, 97(10), 1361-1371.Springer Science and Business Media LLC. doi: 10.1038/sj.bjc.6604038.

Babu, R., Zhang, J., Beckman, E.J., Virji, M., Pasculle, W.A., & Wells, A. (2006). Antimicrobial activities of silver used as a polymerization catalyst for a wound-healing matrix. BIOMATERIALS, 27(24), 4304-4314.Elsevier BV. doi: 10.1016/j.biomaterials.2006.03.038.

Bodnar, R.J., Yates, C.C., & Wells, A. (2006). IP-10 blocks vascular endothelial growth factor-induced endothelial cell motility and tube formation via inhibition of calpain. CIRCULATION RESEARCH, 98(5), 617-625.Ovid Technologies (Wolters Kluwer Health). doi: 10.1161/01.RES.0000209968.66606.10.

Gallion, H., Christopherson, W.A., Coleman, R.L., Demars, L., Herzog, T., Hosford, S., Schellhas, H., Wells, A., & Sevin, B.U. (2006). Progression-free interval in ovarian cancer and predictive value of an ex vivo chemoresponse assay. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 16(1), 194-201.BMJ. doi: 10.1111/j.1525-1438.2006.00301.x.

Kharait, S., Dhir, R., Lauffenburger, D., & Wells, A. (2006). Protein kinase Cdelta signaling downstream of the EGF receptor mediates migration and invasiveness of prostate cancer cells. Biochem Biophys Res Commun, 343(3), 848-856.Elsevier BV. doi: 10.1016/j.bbrc.2006.03.044.

Krishna, P., Rosen, C.A., Branski, R.C., Wells, A., & Hebda, P.A. (2006). Primed fibroblasts and exogenous decorin: Potential treatments for subacute vocal fold scar. OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 135(6), 937-945.Wiley. doi: 10.1016/j.otohns.2006.07.011.

Satish, L., Lyons-Weiler, J., Hebda, P.A., & Wells, A. (2006). Gene expression patterns in isolated keloid fibroblasts. WOUND REPAIR AND REGENERATION, 14(4), 463-470.Wiley. doi: 10.1111/j.1743-6109.2006.00135.x.

Shao, H., Chou, J., Baty, C.J., Burke, N.A., Watkins, S.C., Beer Stolz, D., & Wells, A. (2006). Spatial localization of m-calpain to the plasma membrane by phosphoinositide biphosphate binding during epidermal growth factor receptor-mediated activation. MOLECULAR AND CELLULAR BIOLOGY, 26(14), 5481-5496.Informa UK Limited. doi: 10.1128/MCB.02243-05.

Smith, B.R., Wells, A., Alexander, C.B., Bovill, E., Campbell, S., Dasgupta, A., Fung, M., Haller, B., Howe, J.G., Parvin, C., Peerschke, E., Rinder, H., Spitalnik, S., Weiss, R., Wener, M., & Laboratory, A.C. (2006). Curriculum content and evaluation of resident competency in clinical pathology (Laboratory medicine): A proposal. CLINICAL CHEMISTRY, 52(6), 917-949.Oxford University Press (OUP). doi: 10.1373/clinchem.2005.066076.

Smith, K.D., Wells, A., & Lauffenburyer, D.A. (2006). Multiple signaling pathways mediate compaction of collagen matrices by EGF-stimulated fibroblasts. EXPERIMENTAL CELL RESEARCH, 312(11), 1970-1982.Elsevier BV. doi: 10.1016/j.yexcr.2006.02.022.

Tamama, K., Fan, V.H., Griffith, L.G., Blair, H.C., & Wells, A. (2006). Epidermal growth factor as a candidate for ex vivo expansion of bone marrow-derived mesenchymal stem cells. STEM CELLS, 24(3), 686-695.Oxford University Press (OUP). doi: 10.1634/stemcells.2005-0176.

Wells, A., & Smith, B. (2006). Counterpoint developing a clinical pathology curriculum to meet current and future needs. CLINICAL CHEMISTRY, 52(6), 971-972.Oxford University Press (OUP). doi: 10.1373/clinchem.2006.070540.

Wells, A., Harms, B., Iwabu, A., Koo, L., Smith, K., Griffith, L., & Lauffenburger, D.A. (2006). Motility signaled from the EGF receptor and related systems. Methods Mol Biol, 327, 159-177.Humana Press. doi: 10.1385/1-59745-012-X:159.

Wells, A., Smith, B.R., & Sacks, D.B. (2006). The challenge of training pathologists in the 21st century. HUMAN PATHOLOGY, 37(8), 932-933.Elsevier BV. doi: 10.1016/j.humpath.2006.01.033.

Yu, G.Y., Tseng, G.C., Yu, Y.P., Gavel, T., Nelson, J., Wells, A., Michalopoulos, G., Kokkinakis, D., & Luo, J.H. (2006). CSR1 suppresses tumor growth and metastasis of prostate cancer. AMERICAN JOURNAL OF PATHOLOGY, 168(2), 597-607.Elsevier BV. doi: 10.2353/ajpath.2006.050620.

Zaman, M.H., Trapani, L.M., Siemeski, A., MacKellar, D., Gong, H., Kamm, R.D., Wells, A., Lauffenburger, D.A., & Matsudaira, P. (2006). Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(29), 10889-10894.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.0604460103.

Zhou, W., Grandis, J.R., & Wells, A. (2006). STAT3 is required but not sufficient for EGF receptor-mediated migration and invasion of human prostate carcinoma cell lines. BRITISH JOURNAL OF CANCER, 95(2), 164-171.Springer Science and Business Media LLC. doi: 10.1038/sj.bjc.6603234.

Hautaniemi, S., Kharait, S., Iwabu, A., Wells, A., & Lauffenburger, D.A. (2005). Modeling of signal-response cascades using decision tree analysis. BIOINFORMATICS, 21(9), 2027-2035.Oxford University Press (OUP). doi: 10.1093/bioinformatics/bti278.

Hendriks, B.S., Orr, G., Wells, A., Wiley, H.S., & Lauffenburger, D.A. (2005). Parsing ERK activation reveals quantitatively equivalent contributions from epidermal growth factor receptor and HER2 in human mammary epithelial cells. J Biol Chem, 280(7), 6157-6169.Elsevier BV. doi: 10.1074/jbc.M410491200.

Lai, S.Y., Childs, E.E., Xi, S., Coppelli, F.M., Gooding, W.E., Wells, A., Ferris, R.L., & Grandis, J.R. (2005). Erratum: Erythropoietin-mediated activation of JAK-STAT signaling contributes to cellular invasion in head and neck squamous cell carcinoma. Oncogene, 24(55), 8216.Springer Science and Business Media LLC. doi: 10.1038/sj.onc.1209224.

Lai, S.Y., Childs, E.E., Xi, S.C., Coppelli, F.M., Gooding, W.E., Wells, A., Ferris, R.L., & Grandis, J.R. (2005). Erythropoietin-mediated activation of JAK-STAT signaling contributes to cellular invasion in head and neck squamous cell carcinoma. ONCOGENE, 24(27), 4442-4449.Springer Science and Business Media LLC. doi: 10.1038/sj.onc.1208635.

Satish, L., Blair, H.C., Glading, A., & Wells, A. (2005). Interferon-inducible protein 9 (CXCL11)-induced cell motility in keratinocytes requires calcium flux-dependent activation of μ-calpain. MOLECULAR AND CELLULAR BIOLOGY, 25(5), 1922-1941.Informa UK Limited. doi: 10.1128/MCB.25.5.1922-1941.2005.

Wang, J., Zhang, X., Thomas, S.M., Grandis, J.R., Wells, A., Chen, Z., & Ferris, R.L. (2005). Chemokine receptor 7 activates phosphoinositide-3 kinase-mediated invasive and prosurvival pathways in head and neck cancer cells independent of EGFR. ONCOGENE, 24(38), 5897-5904.Springer Science and Business Media LLC. doi: 10.1038/sj.onc.1208740.

Wells, A. (2005). EGFR in metastasis. Signal, 6(2), 17-19.

Wells, A., Huttenlocher, A., & Lauffenburger, D.A. (2005). Calpain proteases in cell adhesion and motility. INTERNATIONAL REVIEW OF CYTOLOGY - A SURVEY OF CELL BIOLOGY, VOL 245, 245, 1-16.Elsevier. doi: 10.1016/S0074-7696(05)45001-9.

Yates, C., Wells, A., & Turner, T. (2005). Luteinising hormone-releasing hormone analogue reverses the cell adhesion profile of EGFR overexpressing DU-145 human prostate carcinoma subline. BRITISH JOURNAL OF CANCER, 92(2), 366-375.Springer Science and Business Media LLC. doi: 10.1038/sj.bjc.6602350.

Glading, A., Bodnar, R.J., Reynolds, I.J., Shiraha, H., Satish, L., Potter, D.A., Blair, H.C., & Wells, A. (2004). Epidermal growth factor activates m-calpain (calpain II), at least in part, by extracellular signal-regulated kinase-mediated phosphorylation (vol 24, pg 2499, 2004). MOLECULAR AND CELLULAR BIOLOGY, 24(13), 6116.Informa UK Limited. doi: 10.1128/MCB.24.13.6116.2004.

Glading, A., Bodnar, R.J., Reynolds, I.J., Shiraha, H., Satish, L., Potter, D.A., Blair, H.C., & Wells, A. (2004). Epidermal growth factor activates m-calpain (calpain II), at least in part, by extracellular signal-regulated kinase-mediated phosphorylation. MOLECULAR AND CELLULAR BIOLOGY, 24(6), 2499-2512.Informa UK Limited. doi: 10.1128/MCB.24.6.2499-2512.2004.

Iwabu, A., Smith, K., Allen, F.D., Lauffenburger, D.A., & Wells, A. (2004). Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C δ-dependent pathway. JOURNAL OF BIOLOGICAL CHEMISTRY, 279(15), 14551-14560.Elsevier BV. doi: 10.1074/jbc.M311981200.

Jing, L., Liu, L.J., Yu, Y.P., Dhir, R., Acquafondada, M., Landsittel, D., Cieply, K., Wells, A., & Luo, J.H. (2004). Expression of myopodin induces suppression of tumor growth and metastasis. AMERICAN JOURNAL OF PATHOLOGY, 164(5), 1799-1806.Elsevier BV. doi: 10.1016/S0002-9440(10)63738-8.

Kornblith, P., Ochs, R.L., Wells, A., Gabrin, M.J., Piwowar, J., Chattopadhyay, A., George, L.D., & Burholt, D. (2004). Differential in vitro effects of chemotherapeutic agents on primary cultures of human ovarian carcinoma. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 14(4), 607-615.BMJ. doi: 10.1111/j.1048-891X.2004.14408.x.

Larsen, A.K., De Veyra, T., Jia, Z.C., Wells, A., Dutt, P., & Elce, J.S. (2004). Expression of human, mouse, and rat m-calpains in Escherichia coli and in murine fibroblasts. PROTEIN EXPRESSION AND PURIFICATION, 33(2), 246-255.Elsevier BV. doi: 10.1016/j.pep.2003.10.005.

Mamoune, A., Kassis, J., Kharait, S., Kloeker, S., Manos, E., Jones, D.A., & Wells, A. (2004). DU145 human prostate carcinoma invasiveness is modulated by urokinase receptor (uPAR) downstream of epidermal growth factor receptor (EGFR) signaling. EXPERIMENTAL CELL RESEARCH, 299(1), 91-100.Elsevier BV. doi: 10.1016/j.yexcr.2004.05.008.

Priya, K.S., Arumugam, G., Rathinam, B., Wells, A., & Babu, M. (2004). Celosia argentea Linn. leaf extract improves wound healing in a rat burn wound model. WOUND REPAIR AND REGENERATION, 12(6), 618-625.Wiley. doi: 10.1111/j.1067-1927.2004.12603.x.

Satish, L., Babu, M., Tran, K.T., Hebda, P.A., & Wells, A. (2004). Keloid fibroblast responsiveness to epidermal growth factor and activation of downstream intracellular signaling pathways. WOUND REPAIR AND REGENERATION, 12(2), 183-192.Wiley. doi: 10.1111/j.1067-1927.2004.012111.x.

Tran, K.T., Griffith, L., & Wells, A. (2004). Extracellular matrix signaling through growth factor receptors during wound healing. WOUND REPAIR AND REGENERATION, 12(3), 262-268.Wiley. doi: 10.1111/j.1067-1927.2004.012302.x.

Wells, A., & Lillien, L. (2004). Attraction or repulsion: a matter of individual taste?. Sci STKE, 2004(253), pe47.American Association for the Advancement of Science (AAAS). doi: 10.1126/stke.2532004pe47.

Yagi, Y., Ahmed, I., Gross, W., Becich, M.J., Demetris, A.J., Wells, A., Wiley, C.A., Michalopoulos, G.K., Yousem, S.A., Barnes, B., & Gilbertson, J.R. (2004). Webcasting pathology department conferences in a geographically distributed medical center. HUMAN PATHOLOGY, 35(7), 790-797.Elsevier BV. doi: 10.1016/j.humpath.2004.03.013.

Chou, J., Burke, N.A., Iwabu, A., Watkins, S.C., & Wells, A. (2003). Directional motility induced by epidermal growth factor requires Cdc42. EXPERIMENTAL CELL RESEARCH, 287(1), 47-56.Elsevier BV. doi: 10.1016/S0014-4827(03)00119-8.

Hebda, P.A., Whaley, D., Kim, H.G., & Wells, A. (2003). Absence of inhibition of cutaneous wound healing in mice by oral doxycycline. WOUND REPAIR AND REGENERATION, 11(5), 373-379.Wiley. doi: 10.1046/j.1524-475X.2003.11510.x.

Kornblith, P., Wells, A., Gabrin, M.J., Piwowar, J., Chattopadhyay, A., George, L.D., Ochs, R.L., & Burholt, D. (2003). In vitro responses of ovarian cancers to platinums and taxanes. Anticancer Research, 23(1 B), 543-548.

Kornblith, P., Wells, A., Gabrin, M.J., Piwowar, J., George, L.D., Ochs, R.L., & Burholt, D. (2003). Breast cancer -: Response rates to chemotherapeutic agents studied in vitro. ANTICANCER RESEARCH, 23(4), 3405-3411.

Lauffenburger, D.A., & Wells, A. (2003). Quantitative parsing of cell multi-tasking in wound repair and tissue morphogenesis. BIOPHYSICAL JOURNAL, 84(6), 3499-3500.Elsevier BV. doi: 10.1016/S0006-3495(03)75084-X.

Mamoune, A., Luo, J.H., Lauffenburger, D.A., & Wells, A. (2003). Calpain-2 as a target for limiting prostate cancer invasion. CANCER RESEARCH, 63(15), 4632-4640.

Ochs, R.L., Fensterer, J., Ohori, N.P., Wells, A., Gabrin, M., George, L.D., & Kornblith, P. (2003). Evidence for the isolation, growth, and characterization of malignant cells in primary cultures of human tumors. IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 39(1-2), 63-70. doi: 10.1290/1543-706X(2003)039<0063:EFTIGA>2.0.CO;2.

Satish, L., Yager, D., & Wells, A. (2003). Glu-Leu-Arg-negative CXC chemokine interferon γ inducible protein-9 as a mediator of epidermal-dermal communication during wound repair. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 120(6), 1110-1117.Elsevier BV. doi: 10.1046/j.1523-1747.2003.12230.x.

Smith, S.D., Jia, Z.C., Huynh, K.K., Wells, A., & Elce, J.S. (2003). Glutamate substitutions at a PKA consensus site are consistent with inactivation of calpain by phosphorylation. FEBS LETTERS, 542(1-3), 115-118.Wiley. doi: 10.1016/S0014-5793(03)00361-2.

Thomas, S.M., Coppelli, F.M., Wells, A., Gooding, W.E., Song, J., Kassis, J., Drenning, S.D., & Grandis, J.R. (2003). Epidermal growth factor receptor-stimulated activation of phospholipase Cγ-1 promotes invasion of head and neck squamous cell carcinoma. CANCER RESEARCH, 63(17), 5629-5635.

Tran, K.T., Rusu, S.D., Satish, L., & Wells, A. (2003). Aging-related attenuation of EGF receptor signaling is mediated in part by increased protein tyrosine phosphatase activity. EXPERIMENTAL CELL RESEARCH, 289(2), 359-367.Elsevier BV. doi: 10.1016/S0014-4827(03)00287-8.

Wells, A., & Grandis, J.R. (2003). Phospholipase C-γ1 in tumor progression. CLINICAL & EXPERIMENTAL METASTASIS, 20(4), 285-290.Springer Science and Business Media LLC. doi: 10.1023/A:1024088922957.

Wells, A., & Huttenlocher, A. (2003). Calpain. In Handbook of Cell Signaling. 2-3, (pp. 105-111).Elsevier. doi: 10.1016/b978-012124546-7/50502-7.

Allen, F.D., Asnes, C.F., Chang, P., Elson, E.L., Lauffenburger, D.A., & Wells, A. (2002). Epidermal growth factor induces acute matrix contraction and subsequent calpain-modulated relaxation. WOUND REPAIR AND REGENERATION, 10(1), 67-76.Wiley. doi: 10.1046/j.1524-475X.2002.10701.x.

Chou, J., Stolz, D.B., Burke, N.A., Watkins, S.C., & Wells, A. (2002). Distribution of gelsolin and phosphoinositol 4,5-bisphosphate in lamellipodia during EGF-induced motility. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 34(7), 776-790.Elsevier BV. doi: 10.1016/S1357-2725(01)00177-7.

Glading, A., Lauffenburger, D.A., & Wells, A. (2002). Cutting to the chase: calpain proteases in cell motility. TRENDS IN CELL BIOLOGY, 12(1), 46-54.Elsevier BV. doi: 10.1016/S0962-8924(01)02179-1.

Kassis, J., Maeda, A., Teramoto, N., Takada, K., Wu, C.Y., Klein, G., & Wells, A. (2002). EBV-expressing AGS gastric carcinoma cell sublines present increased motility and invasiveness. INTERNATIONAL JOURNAL OF CANCER, 99(5), 644-651.Wiley. doi: 10.1002/ijc.10382.

Kassis, J., Radinsky, R., & Wells, A. (2002). Motility is rate-limiting for invasion of bladder carcinoma cell lines. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 34(7), 762-775.Elsevier BV. doi: 10.1016/S1357-2725(01)00173-X.

Shiraha, H., Glading, A., Chou, J., Jia, Z.C., & Wells, A. (2002). Activation of m-calpain (calpain II) by epidermal growth factor is limited by protein kinase a phosphorylation of m-calpain. MOLECULAR AND CELLULAR BIOLOGY, 22(8), 2716-2727.Informa UK Limited. doi: 10.1128/MCB.22.8.2716-2727.2002.

Wells, A., & Marti, U. (2002). Signalling shortcuts: cell-surface receptors in the nucleus?. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 3(9), 697-6U1.Springer Science and Business Media LLC. doi: 10.1038/nrm905.

Wells, A., Kassis, J., Solava, J., Turner, T., & Lauffenburger, D.A. (2002). Growth factor-induced cell motility in tumor invasion. ACTA ONCOLOGICA, 41(2), 124-130.MJS Publishing, Medical Journals Sweden AB. doi: 10.1080/028418602753669481.

Wells, A., Kharait, S., Yates, C., & Satish, L. (2002). 19 Calpain proteases in prostate carcinoma. Handbook of Immunohistochemistry and in Situ Hybridization of Human Carcinomas, 2, 463-469.Elsevier. doi: 10.1016/s1874-5784(02)80051-4.

Wells, A., Souto, J.C.S., Solava, J., Kassis, J., Bailey, K.J., & Turner, T. (2002). Luteinizing hormone-releasing hormone agonist limits DU-145 prostate cancer growth by attenuating epidermal growth factor receptor signaling. CLINICAL CANCER RESEARCH, 8(4), 1251-1257.

Babu, M., & Wells, A. (2001). Dermal-epidermal communication in wound healing. WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE, 13(5), 183-189.

Barbieri, M.A., Heath, C.M., Peters, E.M., Wells, A., Davis, J.N., & Stahl, P.D. (2001). Phosphatidylinositol-4-phosphate 5-kinase-1β is essential for epidermal growth factor receptor-mediated endocytosis. JOURNAL OF BIOLOGICAL CHEMISTRY, 276(50), 47212-47216.Elsevier BV. doi: 10.1074/jbc.C100490200.

Deb, T.B., Su, L., Wong, L., Bonvini, E., Wells, A., David, M., & Johnson, G.R. (2001). Epidermal growth factor (EGF) receptor kinase-independent signaling by EGF. JOURNAL OF BIOLOGICAL CHEMISTRY, 276(18), 15554-15560.Elsevier BV. doi: 10.1074/jbc.M100928200.

Glading, A., Überall, F., Keyse, S.M., Lauffenburger, D.A., & Wells, A. (2001). Membrane proximal ERK signaling is required for M-calpain activation downstream of epidermal growth factor receptor signaling. JOURNAL OF BIOLOGICAL CHEMISTRY, 276(26), 23341-23348.Elsevier BV. doi: 10.1074/jbc.M008847200.

Kassis, J., Lauffenburger, D.A., Turner, T., & Wells, A. (2001). Tumor invasion as dysregulated cell motility. SEMINARS IN CANCER BIOLOGY, 11(2), 105-117.Elsevier BV. doi: 10.1006/scbi.2000.0362.

Lauffenburger, D.A., & Wells, A. (2001). Getting a grip: new insights for cell adhesion and traction. NATURE CELL BIOLOGY, 3(5), E110-E112.Springer Science and Business Media LLC. doi: 10.1038/35074631.

Manos, E.J., Kim, M.L.H., Kassis, J., Chang, P.Y., Wells, A., & Jones, D.A. (2001). Dolichol-phosphate-mannose-3 (DPM3)/prostin-1 is a novel phospholipase C-γ regulated gene negatively associated with prostate tumor invasion. ONCOGENE, 20(22), 2781-2790.Springer Science and Business Media LLC. doi: 10.1038/sj.onc.1204379.

Swindle, C.S., Tran, K.T., Johnson, T.D., Banerjee, P., Mayes, A.M., Griffith, L., & Wells, A. (2001). Epidermal growth factor (EGF)-like repeats of human tenascin-C as ligands for EGF receptor. JOURNAL OF CELL BIOLOGY, 154(2), 459-468.Rockefeller University Press. doi: 10.1083/jcb.200103103.

Barbieri, M.A., Roberts, R.L., Gumusboga, A., Highfield, H., Alvarez-Dominguez, C., Wells, A., & Stahl, P.D. (2000). Epidermal growth factor and membrane trafficking: EGF receptor activation of endocytosis requires Rab5a. JOURNAL OF CELL BIOLOGY, 151(3), 539-550.Rockefeller University Press. doi: 10.1083/jcb.151.3.539.

Botelho, R.J., Teruel, M., Dierckman, R., Anderson, R., Wells, A., York, J.D., Meyer, T., & Grinstein, S. (2000). Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis. JOURNAL OF CELL BIOLOGY, 151(7), 1353-1367.Rockefeller University Press. doi: 10.1083/jcb.151.7.1353.

Glading, A., Chang, P., Lauffenburger, D.A., & Wells, A. (2000). Epidermal growth factor receptor activation of calpain is required for fibroblast motility and occurs via an ERK/MAP kinase signaling pathway. JOURNAL OF BIOLOGICAL CHEMISTRY, 275(4), 2390-2398.Elsevier BV. doi: 10.1074/jbc.275.4.2390.

Haugh, J.M., Wells, A., & Lauffenburger, D.A. (2000). Mathematical modeling of epidermal growth factor receptor signaling through the phospholipase C pathway: mechanistic insights and predictions for molecular interventions. Biotechnol Bioeng, 70(2), 225-238.Wiley. doi: 10.1002/1097-0290(20001020)70:2<225::aid-bit12>3.0.co;2-s.

Maheshwari, G., Brown, G., Lauffenburger, D.A., Wells, A., & Griffith, L.G. (2000). Cell adhesion and motility depend on nanoscale RGD clustering. JOURNAL OF CELL SCIENCE, 113(10), 1677-1686.The Company of Biologists. doi: 10.1242/jcs.113.10.1677.

Marti, U., & Wells, A. (2000). The nuclear accumulation of a variant epidermal growth factor receptor (EGFR) lacking the transmembrane domain requires coexpression of a full-length EGFR. Mol Cell Biol Res Commun, 3(1), 8-14.Elsevier BV. doi: 10.1006/mcbr.2000.0177.

Shiraha, H., Gupta, K., Drabik, K., & Wells, A. (2000). Aging fibroblasts present reduced epidermal growth factor (EGF) responsiveness due to preferential loss of EGF receptors. JOURNAL OF BIOLOGICAL CHEMISTRY, 275(25), 19343-19351.Elsevier BV. doi: 10.1074/jbc.M000008200.

Wells, A. (2000). Tumor invasion: role of growth factor-induced cell motility. Adv Cancer Res, 78, 31-101.Elsevier. doi: 10.1016/s0065-230x(08)61023-4.

Haugh, J.M., Huang, A.C., Wiley, H.S., Wells, A., & Lauffenburger, D.A. (1999). Internalized epidermal growth factor receptors participate in the activation of p21ras in fibroblasts. JOURNAL OF BIOLOGICAL CHEMISTRY, 274(48), 34350-34360.Elsevier BV. doi: 10.1074/jbc.274.48.34350.

Kassis, J., Moellinger, J., Lo, H., Greenberg, N.M., Kim, H.G., & Wells, A. (1999). A role for phospholipase C-γ-mediated signaling in tumor cell invasion. CLINICAL CANCER RESEARCH, 5(8), 2251-2260.

Shiraha, H., Glading, A., Gupta, K., & Wells, A. (1999). IP-10 inhibits epidermal growth factor-induced motility by decreasing epidermal growth factor receptor-mediated calpain activity. JOURNAL OF CELL BIOLOGY, 146(1), 243-253.Rockefeller University Press. doi: 10.1083/jcb.146.1.243.

Wells, A., Ware, M.F., Allen, F.D., & Lauffenburger, D.A. (1999). Shaping up for shipping out: PLCγ signaling of morphology changes in EGF-stimulated fibroblast migration. Cell Motility and the Cytoskeleton, 44(4), 227-233. doi: 10.1002/(SICI)1097-0169(199912)44:4<227::AID-CM1>3.0.CO;2-B.

Popescu, I., Snyder, M.E., Iasella, C.J., Hannan, S.J., Koshy, R., Burke, R., Das, A., Brown, M.J., Lyons, E.J., Lieber, S.C., Chen, X., Sembrat, J.C., An, X., Linstrum, K., Kitsios, G., Konstantinidis, I., Saul, M., Kass, D.J., Alder, J.K., Chen, B.B., Lendermon, E.A., Kilaru, S., Johnson, B., Morrell, M.R., Pilewski, J.M., Kiss, J.E., Wells, A.H., Morris, A., McVerry, B.J., McMahon, D.K., Triulzi, D.J., Chen, K., Sanchez, P.G., & McDyer, J.F. CD4+T cell lymphopenia and dysfunction in severe COVID-19 disease is autocrine TNF-α/TNFRI-dependent. Cold Spring Harbor Laboratory. doi: 10.1101/2021.06.02.446831.

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