Afshin Beheshti

Afshin Beheshti, PhD is a Professor of Surgery and of Computational & Systems Biology at the University of Pittsburgh School. He serves as Director of the Center for Space Biomedicine at the Trivedi Institute for Space and Global Biomedicine and as Associate Director of the McGowan Institute for Regenerative Medicine at Pitt. In addition, Dr. Beheshti holds a visiting scientist appointment at the Broad Institute of MIT and Harvard.

Dr. Beheshti earned his PhD in physics from Florida State University in 2002 before transitioning to postdoctoral research in cancer biology, systems biology, space biology, and radiation biology. From 2006 to 2011, he was part of a NASA Specialized Center of Research (NSCOR) project focused on the cancer risks of space radiation, during which he published several influential studies. During this period, he also applied systems biology approaches to explore how aging affects tumor growth dynamics.

In 2014, Dr. Beheshti joined Tufts University School of Medicine/Tufts Medical Center as an Assistant Professor, where his research as a systems biologist centered on cancer, particularly microRNAs (miRNAs), aging, cancer drug targets, and the development of novel immunotherapies. In April 2017, he moved to NASA’s Ames Research Center, contributing to the development of the GeneLab genomics platform. Shortly thereafter, he secured multiple research grants from NASA, the Department of Defense, and other agencies. These projects expanded his work into the roles of miRNAs and mitochondria in space biology, the development of countermeasures against space radiation and microgravity, as well as studies of COVID-19, long COVID, cancer, and the effects of high altitude on human biology.

In late 2024, Dr. Beheshti left NASA to join the University of Pittsburgh, where he was appointed Professor of Surgery and Computational & Systems Biology, Director of Pitt’s new Center for Space Biomedicine, and Associate Director of the McGowan Institute. In these roles, he launched a university-wide space biomedicine initiative to explore space health issues, develop countermeasures for spaceflight-induced health risks, and create outreach/education programs in space biology. He brings leading expertise in mitochondrial function and microRNA biology to this program, bridging spaceflight research with terrestrial medicine, for example, his work on spaceflight-induced cellular changes also informs understanding of Earth-bound conditions such as long COVID. In January 2026, his Center for Space Biomedicine became part of newly launched Trivedi Institute for Space and Global Biomedicine.

Dr. Beheshti also leads two non-profit organizations. He is the President of the COVID-19 International Research Team (COV-IRT), an alliance he founded in March 2020 to focus on COVID-19 and long COVID research. Under his leadership, COV-IRT has produced numerous publications and brought together researchers worldwide to tackle the COVID-19 pandemic. In August 2023, he launched a second non-profit initiative aimed at democratizing access to artificial intelligence, this effort led to the design and implementation of a free personal AI assistant named Kwaai.

As a scientific leader, Dr. Beheshti has spearheaded several high-impact collaborative projects. He was one of the leads of the Space Omics and Medical Atlas (SOMA) project, a partnership with Nature Portfolio that coordinated the largest-ever collection of space biology papers. This global effort involved over 100 institutions across more than 25 countries and resulted in a comprehensive compendium of manuscripts, data, protocols, and tools for aerospace medicine and space biology. Dr. Beheshti contributed to 22 papers in the SOMA collection (serving as senior author on nine), and his contributions were pivotal in securing a cover feature for the August 2024 issue of Nature, which highlighted several of the project’s studies (including one of his as senior author).

Currently, Dr. Beheshti also leads the Human Adaptation to Spaceflight study, a NASA-funded international collaboration examining health data from more than 70 astronauts over 12 years of International Space Station missions. This project, one of the most comprehensive longitudinal studies of space health, aims to determine the key factors that impact astronauts during long-duration space travel (such as bone loss, cardiovascular and renal issues, circadian rhythm disruptions, potential cancer risks, and ocular disorders) and to develop strategies to mitigate these risks. Notably, his team is integrating advanced machine-learning techniques to predict potential therapeutics that could target the biological changes caused by spaceflight, in order to counteract spaceflight-induced metabolic and molecular disruptions.

In addition to his space-related work, Dr. Beheshti remains at the forefront of biomedical research on Earth. One study he is co-senior author of in December 2024 in Proceedings of the National Academy of Sciences (PNAS) elucidated how COVID-19 causes widespread organ damage. This study showed that SARS-CoV-2 infection disrupts mitochondrial function and over activates the renin-angiotensin-aldosterone system (RAAS), triggering a cascade of inflammation that damages multiple organs. These findings helped explain the mechanisms behind severe COVID-19 and long COVID and pointed to new therapeutic targets for preventing or mitigating such outcomes. The project exemplified Dr. Beheshti’s collaborative approach: as president of COV-IRT, he convened a multi-institution team (including researchers from Johns Hopkins, the Children’s Hospital of Philadelphia, Weill Cornell Medicine and others) to tackle this complex study.

Dr. Beheshti’s contributions have earned him wide recognition and numerous honors. His awards include the International Space Station Research & Development Award for Compelling Results in Biology (from the American Astronautical Society and NASA), the NASA Exceptional Scientific Achievement Medal, the “One KBR” Award, and the NASA Outstanding Service Award (NASA Ames Safety Award Program II).

Outside of work, Dr. Beheshti is also an avid musician. He performs with a Boston-based band called Medical Maps, which released an album titled That is That in 2023 (available on their Bandcamp page).

(2022) NASA Outstanding Service Award: NASA Ames Safety Award Program II.
(2021) One KBR Award.
(2021) International Space Station Research & Development Award for Compelling Results in Biology.
(2021) NASA Exceptional Scientific Achievement Medal.

PhD in Physics, Florida State University, 1997 - 2002
BS in Physics, University of Minnesota, 1993 - 1997

Akbarialiabad, H., Parvar, S.Y., Grada, A., Bunick, C.G., Shimada, K., Melin, M.M., Taghrir, M.H., Crucian, B., Costes, S.V., Sanders, L.M., Paller, A., Leachman, S.A., Alavi, A., Lehman, J.S., El-Hamdi, N.S., Christiansen, R., Tarbox, M., Grant-Kels, J.M., Mostaghimi, A., West, C., Goldust, M., Keshtmand, G., Mesinkovska, N.A., Sadeghian, N., Beheshti, A., & Murrell, D.F. (2026). Space-related dermatoses. CLINICS IN DERMATOLOGY, 44(1), 87-99.Elsevier. doi: 10.1016/j.clindermatol.2025.10.006.
Lopes-Ribeiro, Á., Marques-Ferreira, G., Pereira Araujo, F., de Melo Oliveira, P., Lourenço, A.A., Cardoso Corrêa-Dias, L., Pereira Santos, T.A., Wilker Teixeira, C., Gomes de Pontes, L., de Melo Rocha, V., de Sousa Reis, E.V., Henriques Pereira, S., Alves Oliveira Paim, A., Flores Andrade, L.A., Martins da Mata, C.P.S., Guimarães da Fonseca, F., Santos Coelho, F.D., Pacheco Coelho, R., Pacheco Coelho, G., Peruhype-Magalhães, V., Teixeira-Carvalho, A., Martins-Filho, O.A., Beheshti, A., Tsuji, M., & Coelho-Dos-Reis, J.G.A. (2026). Immune Landscape of COVID-19 recovery: Nucleocapsid as a major target of CD8+ T cell antiviral responses in convalescent HLA-A*2+ individuals from Brazil. J Leukoc Biol, 118(5), qiag050.Oxford University Press (OUP). doi: 10.1093/jleuko/qiag050.
Nygren, S., Erdogan, O., Avci, P., Daniels, A., Rassool, R., Beheshti, A., & Galeano, D. (2026). RAG-based architectures for drug side effect retrieval using compact LLMs. Sci Rep, 16(1).Springer Nature. doi: 10.1038/s41598-026-41495-2.
Winer, D.A., Du, H., Kim, J., Chang, V., Burke, M., Winer, S., Costes, S.V., Frippiat, J.P., Sams, C., Paul, A.M., Wu, H., Ullrich, O., Baatout, S., Beheshti, A., Mason, C.E., Choukér, A., & Crucian, B.E. (2026). Astroimmunology: the effects of spaceflight and its associated stressors on the immune system. Nat Rev Immunol, 26(3), 189-212.Springer Nature. doi: 10.1038/s41577-025-01226-6.
Ali, N., Beheshti, A., & Hampikian, G. (2025). Space exploration and risk of Parkinson's disease: a perspective review. NPJ Microgravity, 11(1), 1.Springer Nature. doi: 10.1038/s41526-024-00457-6.
Beheshti, A., Schaan, E., & Kosowsky, A. (2025). Moving lens effect: Simulations, forecasts, and foreground mitigation. PHYSICAL REVIEW D, 111(4).American Physical Society (APS). doi: 10.1103/PhysRevD.111.043510.
Chauhan, V., Grybas, V.S., Hoopfer, D., Higginson, C., Ainsbury, E.A., Azimzadeh, O., Beheshti, A., Blattnig, S., Boerma, M., Costes, S.V., Doty, S., Adam-Guillermin, C., Hamada, N., Hinton, P., Huff, J.L., Reynolds, R., Wilkins, R.C., Wood, S., & Yauk, C.L. (2025). Adverse Outcome Pathways Applied to Space Radiation Research. Environ Mol Mutagen, 66(8), 442-462.Wiley. doi: 10.1002/em.70031.
Chia, S.B., Johnson, B.J., Hu, J., Valença-Pereira, F., Chadeau-Hyam, M., Guntoro, F., Montgomery, H., Boorgula, M.P., Sreekanth, V., Goodspeed, A., Davenport, B., De Dominici, M., Zaberezhnyy, V., Schleicher, W.E., Gao, D., Cadar, A.N., Petriz-Otaño, L., Papanicolaou, M., Beheshti, A., Baylin, S.B., Guarnieri, J.W., Wallace, D.C., Costello, J.C., Bartley, J.M., Morrison, T.E., Vermeulen, R., Aguirre-Ghiso, J.A., Rincon, M., & DeGregori, J. (2025). Respiratory viral infections awaken metastatic breast cancer cells in lungs. Nature, 645(8080), 496-506.Springer Nature. doi: 10.1038/s41586-025-09332-0.
D'Addabbo, P., De Grassi, A., De Luca, D.I., Scaglione, V., Francavilla, A.L., Todisco, S., Sgobba, M.N., Guerra, L., Volpicella, M., Beheshti, A., & Pierri, C.L. (2025). SLC25A mitochondrial carriers as biomarkers and therapeutic targets of spaceflight-induced dysfunction: the ADP/ATP carrier (AAC3) as a structural case study. J Transl Med, 24(1), 101.Springer Nature. doi: 10.1186/s12967-025-07505-z.
Davanzo, G.G., Castelucci, B.G., de Souza, G.F., Muraro, S.P., Menezes Dos Reis, L., de Oliveira, I.B., Fachi, J.L., Virgilio-da-Silva, J.V., Berçot, M.R., Fernandes, M.F., de Oliveira, S., Araujo, N.V.P., Ribeiro, G., de Castro, G., Costa, W.L.G., Santoro, A.L., Rodrigues-Luiz, G.F., do Carmo, H.R.P., Breder, I., Mori, M.A., Farias, A.S., Martins-de-Souza, D., Guarnieri, J.W., Wallace, D.C., Vinolo, M.A.R., Proença-Módena, J.L., Beheshti, A., Sposito, A.C., & Moraes-Vieira, P.M. (2025). Obesity-Induced Metabolic Priming Exacerbates SARS-CoV-2 Inflammation. Immunology, 175(3), 323-338.Wiley. doi: 10.1111/imm.13934.
Finch, R.H., Vitry, G., Siew, K., Walsh, S.B., Beheshti, A., Hardiman, G., & da Silveira, W.A. (2025). Author Correction: Spaceflight causes strain-dependent gene expression changes in the kidneys of mice. NPJ Microgravity, 11(1), 12.Springer Nature. doi: 10.1038/s41526-025-00467-y.
Finch, R.H., Vitry, G., Siew, K., Walsh, S.B., Beheshti, A., Hardiman, G., & da Silveira, W.A. (2025). Spaceflight causes strain-dependent gene expression changes in the kidneys of mice. NPJ Microgravity, 11(1), 11.Springer Nature. doi: 10.1038/s41526-025-00465-0.
Guarnieri, J.W., Kim, J., Wallace, D.C., Mason, C.E., Muratani, M., & Beheshti, A. (2025). Methodologies for Mitochondrial Omic Profiling During Spaceflight. Methods Mol Biol, 2878, 273-291.Springer Nature. doi: 10.1007/978-1-0716-4264-1_15.
Haltom, J.A., Trovao, N.S., Guarnieri, J.W., Pan, V., Singh, U., Tsoy, S., O'Leary, C.A., Bram, Y., Widjaja, G.A., Cen, Z., Meller, R., Baylin, S.B., Moss, W.N., Nikolau, B.J., Enguita, F.J., Wallace, D.C., Beheshti, A., Schwartz, R.E., & Wurtele, E.S. (2025). Importance of De Novo Gene Evolution to Emerging Viral Threats: The ORF10 Strain-Restricted Orphan Gene of SARS-CoV-2 Promotes Pathogenesis. In Carvunis, A.R. (Ed.). Mol Biol Evol, 42(10).Oxford University Press (OUP). doi: 10.1093/molbev/msaf211.
Kim, H.J., Tull, A., Beheshti, A., Woo, S.J., & Low, L. (2025). From rodents on the ISS to humans in commercial LEO. NATURE REVIEWS BIOENGINEERING, 3(12), 999-1001.Springer Nature. doi: 10.1038/s44222-025-00383-6.
Lee, R., Ong, J., Waisberg, E., Mader, T., Berdahl, J., Suh, A., Panzo, N., Memon, H., Sampige, R., Katsev, B., Kadipasaoglu, C.M., Mason, C.E., Beheshti, A., Zwart, S.R., Smith, S.M., & Lee, A.G. (2025). Potential Risks of Ocular Molecular and Cellular Changes in Spaceflight. Semin Ophthalmol, 40(8), 756-766.Taylor & Francis. doi: 10.1080/08820538.2025.2471443.
Lee, R., Rayhun, A., Kim, J.K., Meydan, C., Beheshti, A., Sporn, K., Kumar, R., Calixte, J., McNerney, M.W., Shah, J., Waisberg, E., Ong, J., & Mason, C. (2025). Genomic Analysis of Cardiovascular Diseases Utilizing Space Omics and Medical Atlas. Genes (Basel), 16(9).MDPI. doi: 10.3390/genes16090996.
Singh, K., Verma, P., Srivastava, R., Rustagi, Y., Kumar, M., Verma, S.S., Mohanty, S., Beheshti, A., Warren, L., & Sen, C.K. (2025). Erratum: Mission SpaceX CRS-16 RRRM-1 space flight induced skin genomic plasticity via an epigenetic trigger. iScience, 28(11), 112683.Elsevier. doi: 10.1016/j.isci.2025.112683.
Vinken, M., Grimm, D., Baatout, S., Baselet, B., Beheshti, A., Braun, M., Carstens, A.C., Casaletto, J.A., Cools, B., Costes, S.V., De Meulemeester, P., Doruk, B., Eyal, S., Ferreira, M.J.S., Miranda, S., Hahn, C., Helvacıoğlu Akyüz, S., Herbert, S., Krepkiy, D., Lichterfeld, Y., Liemersdorf, C., Krüger, M., Marchal, S., Ritz, J., Schmakeit, T., Stenuit, H., Tabury, K., Trittel, T., Wehland, M., Zhang, Y.S., Putt, K.S., Zhang, Z.Y., & Tagle, D.A. (2025). Taking the 3Rs to a higher level: replacement and reduction of animal testing in life sciences in space research. Biotechnol Adv, 81, 108574.Elsevier. doi: 10.1016/j.biotechadv.2025.108574.
Borg, J., Loy, C., Kim, J., Buhagiar, A., Chin, C., Damle, N., De Vlaminck, I., Felice, A., Liu, T., Matei, I., Meydan, C., Muratani, M., Mzava, O., Overbey, E., Ryon, K.A., Smith, S.M., Tierney, B.T., Trudel, G., Zwart, S.R., Beheshti, A., Mason, C.E.Borg, J. (2024). Spatiotemporal expression and control of haemoglobin in space. Nat Commun, 15(1), 4927.Springer Nature. doi: 10.1038/s41467-024-49289-8.
Camera, A., Tabetah, M., Castañeda, V., Kim, J., Galsinh, A.S., Haro-Vinueza, A., Salinas, I., Seylani, A., Arif, S., Das, S., Mori, M.A., Carano, A., de Oliveira, L.C., Muratani, M., Barker, R., Zaksas, V., Goel, C., Dimokidis, E., Taylor, D.M., Jeong, J., Overbey, E., Meydan, C., Porterfield, D.M., Díaz, J.E., Caicedo, A., Schisler, J.C., Laiakis, E.C., Mason, C.E., Kim, M.S., Karouia, F., Szewczyk, N.J., & Beheshti, A. (2024). Aging and putative frailty biomarkers are altered by spaceflight. Sci Rep, 14(1), 13098.Springer Nature. doi: 10.1038/s41598-024-57948-5.
Chia, S.B., Johnson, B.J., Hu, J., Vermeulen, R., Chadeau-Hyam, M., Guntoro, F., Montgomery, H., Boorgula, M.P., Sreekanth, V., Goodspeed, A., Davenport, B., Pereira, F.V., Zaberezhnyy, V., Schleicher, W.E., Gao, D., Cadar, A.N., Papanicolaou, M., Beheshti, A., Baylin, S.B., Costello, J., Bartley, J.M., Morrison, T.E., Aguirre-Ghiso, J.A., Rincon, M., & DeGregori, J. (2024). Respiratory viral infection promotes the awakening and outgrowth of dormant metastatic breast cancer cells in lungs. Res Sq, rs.3.rs-4210090.Springer Nature. doi: 10.21203/rs.3.rs-4210090/v1.
Cope, H., Elsborg, J., Demharter, S., McDonald, J.T., Wernecke, C., Parthasarathy, H., Unadkat, H., Chatrathi, M., Claudio, J., Reinsch, S., Avci, P., Zwart, S.R., Smith, S.M., Heer, M., Muratani, M., Meydan, C., Overbey, E., Kim, J., Chin, C.R., Park, J., Schisler, J.C., Mason, C.E., Szewczyk, N.J., Willis, C.R.G., Salam, A., & Beheshti, A. (2024). Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology. Commun Med (Lond), 4(1), 106.Springer Nature. doi: 10.1038/s43856-024-00532-9.
Corti, G., Kim, J., Enguita, F., Guarnieri, J., Grossman, L., Costes, S., Fuentealba, M., Scott, R., Magrini, A., Sanders, L., Furman, D., Calleja-Agius, J., Mason, C., Galeano, D., Bottini, M., & Beheshti, A. (2024). To boldly go where no microRNAs have gone before: Spaceflight impact on risk for small-for-gestational-age infants. In Research Square. doi: 10.21203/rs.3.rs-4003363/v1.
Corti, G., Kim, J., Enguita, F.J., Guarnieri, J.W., Grossman, L.I., Costes, S.V., Fuentealba, M., Scott, R.T., Magrini, A., Sanders, L.M., Singh, K., Sen, C.K., Juran, C.M., Paul, A.M., Furman, D., Calleja-Agius, J., Mason, C.E., Galeano, D., Bottini, M., & Beheshti, A. (2024). To boldly go where no microRNAs have gone before: spaceflight impact on risk for small-for-gestational-age infants. Commun Biol, 7(1), 1268.Springer Nature. doi: 10.1038/s42003-024-06944-6.
Corti, G., Kim, J., Enguita, F.J., Guarnieri, J.W., Grossman, L.I., Costes, S.V., Fuentealba, M., Scott, R.T., Magrini, A., Sanders, L.M., Singh, K., Sen, C.K., Juran, C.M., Paul, A.M., Furman, D., Calleja-Agius, J., Mason, C.E., Galeano, D., Bottini, M., & Beheshti, A. (2024). Author Correction: To boldly go where no microRNAs have gone before: spaceflight impact on risk for small-for-gestational-age infants. Commun Biol, 7(1), 1339.Springer Nature. doi: 10.1038/s42003-024-07022-7.
Finch, R.H., Vitry, G., Siew, K., Walsh, S.B., Behesti, A., Hardiman, G., & da Silveira, W.A. (2024). Spaceflight causes strain dependent gene expression changes associated with lipid and extracellular matrix dysregulation in the mouse kidney in vivo. bioRxiv, 2024.03.13.584781.Cold Spring Harbor Laboratory. doi: 10.1101/2024.03.13.584781.
Galeano, D., Imrat, Haltom, J., Andolino, C., Yousey, A., Zaksas, V., Das, S., Baylin, S.B., Wallace, D.C., Slack, F.J., Enguita, F.J., Wurtele, E.S., Teegarden, D., Meller, R., Cifuentes, D., & Beheshti, A. (2024). sChemNET: a deep learning framework for predicting small molecules targeting microRNA function. Nat Commun, 15(1), 9149.Springer Nature. doi: 10.1038/s41467-024-49813-w.
Houerbi, N., Kim, J., Overbey, E.G., Batra, R., Schweickart, A., Patras, L., Lucotti, S., Ryon, K.A., Najjar, D., Meydan, C., Damle, N., Chin, C., Narayanan, S.A., Guarnieri, J.W., Widjaja, G., Beheshti, A., Tobias, G., Vatter, F., Hirschberg, J.W., Kleinman, A., Afshin, E.E., MacKay, M., Chen, Q., Miller, D., Gajadhar, A.S., Williamson, L., Tandel, P., Yang, Q., Chu, J., Benz, R., Siddiqui, A., Hornburg, D., Gross, S., Shirah, B., Krumsiek, J., Mateus, J., Mao, X., Matei, I., & Mason, C.E. (2024). Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight. Nat Commun, 15(1), 4862.Springer Nature. doi: 10.1038/s41467-024-48841-w.
Huang, M., Mark, A., Pham, J., Vera, K., Saravia-Butler, A.M., Beheshti, A., Jiang, Q., & Fisch, K.M. (2024). RNA editing regulates host immune response and T cell homeostasis in SARS-CoV-2 infection. In Ho, P.L. (Ed.). PLoS One, 19(8), e0307450.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0307450.
Jones, C.W., Overbey, E.G., Lacombe, J., Ecker, A.J., Meydan, C., Ryon, K., Tierney, B., Damle, N., MacKay, M., Afshin, E.E., Foox, J., Park, J., Nelson, T.M., Suhail Mohamad, M., Byhaqui, S.G.A., Aslam, B., Tali, U.A., Nisa, L., Menon, P.V., Patel, C.O., Khan, S.A., Ebert, D.J., Everson, A., Schubert, M.C., Ali, N.N., Sarma, M.S., Kim, J., Houerbi, N., Grigorev, K., Garcia Medina, J.S., Summers, A.J., Gu, J., Altin, J.A., Fattahi, A., Hirzallah, M.I., Wu, J.H., Stahn, A.C., Beheshti, A., Klotz, R., Ortiz, V., Yu, M., Patras, L., Matei, I., Lyden, D., Melnick, A., Banerjee, N., Mullane, S., Kleinman, A.S., Loesche, M., Menon, A.S., Donoviel, D.B., Urquieta, E., Mateus, J., Sargsyan, A.E., Shelhamer, M., Zenhausern, F., Bershad, E.M., Basner, M., & Mason, C.E. (2024). Molecular and physiological changes in the SpaceX Inspiration4 civilian crew. Nature, 632(8027), 1155-1164.Springer Nature. doi: 10.1038/s41586-024-07648-x.
Kim, J., Tierney, B.T., Overbey, E.G., Dantas, E., Fuentealba, M., Park, J., Narayanan, S.A., Wu, F., Najjar, D., Chin, C.R., Meydan, C., Loy, C., Mathyk, B., Klotz, R., Ortiz, V., Nguyen, K., Ryon, K.A., Damle, N., Houerbi, N., Patras, L.I., Schanzer, N., Hutchinson, G.A., Foox, J., Bhattacharya, C., Mackay, M., Afshin, E.E., Hirschberg, J.W., Kleinman, A.S., Schmidt, J.C., Schmidt, C.M., Schmidt, M.A., Beheshti, A., Matei, I., Lyden, D., Mullane, S., Asadi, A., Lenz, J.S., Mzava, O., Yu, M., Ganesan, S., De Vlaminck, I., Melnick, A.M., Barisic, D., Winer, D.A., Zwart, S.R., Crucian, B.E., Smith, S.M., Mateus, J., Furman, D., & Mason, C.E. (2024). Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight. Nat Commun, 15(1), 4954.Springer Nature. doi: 10.1038/s41467-024-49211-2.
Mason, C.E., Green, J., Adamopoulos, K.I., Afshin, E.E., Baechle, J.J., Basner, M., Bailey, S.M., Bielski, L., Borg, J., Borg, J., Broddrick, J.T., Burke, M., Caicedo, A., Castañeda, V., Chatterjee, S., Chin, C.R., Church, G., Costes, S.V., De Vlaminck, I., Desai, R.I., Dhir, R., Diaz, J.E., Etlin, S.M., Feinstein, Z., Furman, D., Garcia-Medina, J.S., Garrett-Bakelman, F., Giacomello, S., Gupta, A., Hassanin, A., Houerbi, N., Irby, I., Javorsky, E., Jirak, P., Jones, C.W., Kamal, K.Y., Kangas, B.D., Karouia, F., Kim, J., Kim, J.H., Kleinman, A.S., Lam, T., Lawler, J.M., Lee, J.A., Limoli, C.L., Lucaci, A., MacKay, M., McDonald, J.T., Melnick, A.M., Meydan, C., Mieczkowski, J., Muratani, M., Najjar, D., Othman, M.A., Overbey, E.G., Paar, V., Park, J., Paul, A.M., Perdyan, A., Proszynski, J., Reynolds, R.J., Ronca, A.E., Rubins, K., Ryon, K.A., Sanders, L.M., Glowe, P.S., Shevde, Y., Schmidt, M.A., Scott, R.T., Shirah, B., Sienkiewicz, K., Sierra, M.A., Siew, K., Theriot, C.A., Tierney, B.T., Venkateswaran, K., Hirschberg, J.W., Walsh, S.B., Walter, C., Winer, D.A., Yu, M., Zea, L., Mateus, J., & Beheshti, A. (2024). A second space age spanning omics, platforms and medicine across orbits. Nature, 632(8027), 995-1008.Springer Nature. doi: 10.1038/s41586-024-07586-8.
Mathyk, B.A., Tabetah, M., Karim, R., Zaksas, V., Kim, J., Anu, R.I., Muratani, M., Tasoula, A., Singh, R.S., Chen, Y.K., Overbey, E., Park, J., Cope, H., Fazelinia, H., Povero, D., Borg, J., Klotz, R.V., Yu, M., Young, S.L., Mason, C.E., Szewczyk, N., St Clair, R.M., Karouia, F., & Beheshti, A. (2024). Spaceflight induces changes in gene expression profiles linked to insulin and estrogen. Commun Biol, 7(1), 692.Springer Nature. doi: 10.1038/s42003-023-05213-2.
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Perdyan, A., Jąkalski, M., Horbacz, M., Beheshti, A., & Mieczkowski, J. (2024). Chromosomal positioning and epigenetic architecture influence DNA methylation patterns triggered by galactic cosmic radiation. Sci Rep, 14(1), 1324.Springer Nature. doi: 10.1038/s41598-024-51756-7.
Sandhu, S., Keyworth, M., Karimi-Jashni, S., Alomar, D., Smith, B.J., Kozbenko, T., Doty, S., Hocking, R., Hamada, N., Reynolds, R.J., Scott, R.T., Costes, S.V., Beheshti, A., Yauk, C., Wilkins, R.C., & Chauhan, V. (2024). AOP Report: Development of an adverse outcome pathway for deposition of energy leading to bone loss. Environ Mol Mutagen, 65 Suppl 3(S3), 85-111.Wiley. doi: 10.1002/em.22631.
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Singh, K., Verma, P., Srivastava, R., Rustagi, Y., Kumar, M., Verma, S.S., Mohanty, S., Beheshti, A., Warren, L., & Sen, C.K. (2024). Mission SpaceX CRS-16 RRRM-1 space flight induced skin genomic plasticity via an epigenetic trigger. iScience, 27(12), 111382.Elsevier. doi: 10.1016/j.isci.2024.111382.
Tocci, D., Ducai, T., Stoute, C.A.B., Hopkins, G., Sabbir, M.G., Beheshti, A., & Albensi, B.C. (2024). "Monitoring inflammatory, immune system mediators, and mitochondrial changes related to brain metabolism during space flight". Front Immunol, 15, 1422864.Frontiers. doi: 10.3389/fimmu.2024.1422864.
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Adam, N., Vuong, N.Q., Adams, H., Kuo, B., Beheshti, A., Yauk, C., Wilkins, R., & Chauhan, V. (2022). Evaluating the influences of confounding variables on benchmark dose using a case study in the field of ionizing radiation. Int J Radiat Biol, 98(12), 1845-1855.Taylor & Francis. doi: 10.1080/09553002.2022.2110303.
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Fiore, N.J., Tamer-Mahoney, J.D., Beheshti, A., Nieland, T.J.F., & Kaplan, D.L. (2022). 3D biocomposite culture enhances differentiation of dopamine-like neurons from SH-SY5Y cells: A model for studying Parkinson's disease phenotypes. Biomaterials, 290, 121858.Elsevier. doi: 10.1016/j.biomaterials.2022.121858.
Gatt, C., Tierney, B.T., Madrigal, P., Mason, C.E., Beheshti, A., Telzerow, A., Benes, V., Zahra, G., Bonett, J., Cassar, K., & Borg, J. (2022). The Maleth program: Malta's first space mission discoveries on the microbiome of diabetic foot ulcers. Heliyon, 8(12), e12075.Elsevier. doi: 10.1016/j.heliyon.2022.e12075.
Guarnieri, J.W., Dybas, J.M., Fazelinia, H., Kim, M.S., Frere, J., Zhang, Y., Albrecht, Y.S., Murdock, D.G., Angelin, A., Singh, L.N., Weiss, S.L., Best, S.M., Lott, M.T., Cope, H., Zaksas, V., Saravia-Butler, A., Meydan, C., Foox, J., Mozsary, C., Kidane, Y.H., Priebe, W., Emmett, M.R., Meller, R., Singh, U., Bram, Y., tenOever, B.R., Heise, M.T., Moorman, N.J., Madden, E.A., Taft-Benz, S.A., Anderson, E.J., Sanders, W.A., Dickmander, R.J., Baxter, V.K., Baylin, S.B., Wurtele, E.S., Moraes-Vieira, P.M., Taylor, D., Mason, C.E., Schisler, J.C., Schwartz, R.E., Beheshti, A., & Wallace, D.C. (2022). TARGETED DOWN REGULATION OF CORE MITOCHONDRIAL GENES DURING SARS-COV-2 INFECTION. In bioRxiv. doi: 10.1101/2022.02.19.481089.
Jamison, D.A., Anand Narayanan, S., Trovão, N.S., Guarnieri, J.W., Topper, M.J., Moraes-Vieira, P.M., Zaksas, V., Singh, K.K., Wurtele, E.S., & Beheshti, A. (2022). A comprehensive SARS-CoV-2 and COVID-19 review, Part 1: Intracellular overdrive for SARS-CoV-2 infection. Eur J Hum Genet, 30(8), 889-898.Springer Nature. doi: 10.1038/s41431-022-01108-8.
Karlebach, G., Aronow, B., Baylin, S.B., Butler, D., Foox, J., Levy, S., Meydan, C., Mozsary, C., Saravia-Butler, A.M., Taylor, D.M., Wurtele, E., Mason, C.E., Beheshti, A., & Robinson, P.N. (2022). Betacoronavirus-specific alternate splicing. Genomics, 114(2), 110270.Elsevier. doi: 10.1016/j.ygeno.2022.110270.
Laiakis, E.C., Pinheiro, M., Nguyen, T., Nguyen, H., Beheshti, A., Dutta, S.M., Russell, W.K., Emmett, M.R., & Britten, R.A. (2022). Quantitative proteomic analytic approaches to identify metabolic changes in the medial prefrontal cortex of rats exposed to space radiation. Front Physiol, 13, 971282.Frontiers. doi: 10.3389/fphys.2022.971282.
Madrigal, P., Singh, N.K., Wood, J.M., Gaudioso, E., Hernández-del-Olmo, F., Mason, C.E., Venkateswaran, K., & Beheshti, A. (2022). Machine learning algorithm to characterize antimicrobial resistance associated with the International Space Station surface microbiome. In bioRxiv. doi: 10.1101/2022.02.07.479455.
Madrigal, P., Singh, N.K., Wood, J.M., Gaudioso, E., Hernández-Del-Olmo, F., Mason, C.E., Venkateswaran, K., & Beheshti, A. (2022). Machine learning algorithm to characterize antimicrobial resistance associated with the International Space Station surface microbiome. Microbiome, 10(1), 134.Springer Nature. doi: 10.1186/s40168-022-01332-w.
Park, J., Foox, J., Hether, T., Danko, D.C., Warren, S., Kim, Y., Reeves, J., Butler, D.J., Mozsary, C., Rosiene, J., Shaiber, A., Afshin, E.E., MacKay, M., Rendeiro, A.F., Bram, Y., Chandar, V., Geiger, H., Craney, A., Velu, P., Melnick, A.M., Hajirasouliha, I., Beheshti, A., Taylor, D., Saravia-Butler, A., Singh, U., Wurtele, E.S., Schisler, J., Fennessey, S., Corvelo, A., Zody, M.C., Germer, S., Salvatore, S., Levy, S., Wu, S., Tatonetti, N.P., Shapira, S., Salvatore, M., Westblade, L.F., Cushing, M., Rennert, H., Kriegel, A.J., Elemento, O., Imielinski, M., Rice, C.M., Borczuk, A.C., Meydan, C., Schwartz, R.E., & Mason, C.E. (2022). System-wide transcriptome damage and tissue identity loss in COVID-19 patients. Cell Rep Med, 3(2), 100522.Elsevier. doi: 10.1016/j.xcrm.2022.100522.
Ravi, D., Beheshti, A., Burgess, K., Kritharis, A., Chen, Y., Evens, A.M., & Parekkadan, B. (2022). An Analysis of Transcriptomic Burden Identifies Biological Progression Roadmaps for Hematological Malignancies and Solid Tumors. Biomedicines, 10(11).MDPI. doi: 10.3390/biomedicines10112720.
Saravia-Butler, A.M., Schisler, J.C., Taylor, D., Beheshti, A., Butler, D., Meydan, C., Foox, J., Hernandez, K., Mozsary, C., Mason, C.E., & Meller, R. (2022). Host transcriptional responses in nasal swabs identify potential SARS-CoV-2 infection in PCR negative patients. iScience, 25(11), 105310.Elsevier. doi: 10.1016/j.isci.2022.105310.
Schimmoller, B.J., Trovão, N.S., Isbell, M., Goel, C., Heck, B.F., Archer, T.C., Cardinal, K.D., Naik, N.B., Dutta, S., Daniel, A.R., & Beheshti, A. (2022). Covid-19 Exposure Assessment Tool (CEAT): Easy-to-use tool to quantify exposure based on airflow, group behavior, and infection prevalence in the community. In medRxiv. doi: 10.1101/2022.03.02.22271806.
Schimmoller, B.J., Trovão, N.S., Isbell, M., Goel, C., Heck, B.F., Archer, T.C., Cardinal, K.D., Naik, N.B., Dutta, S., Rohr Daniel, A., & Beheshti, A. (2022). COVID-19 Exposure Assessment Tool (CEAT): Exposure quantification based on ventilation, infection prevalence, group characteristics, and behavior. Sci Adv, 8(39), eabq0593.American Association for the Advancement of Science (AAAS). doi: 10.1126/sciadv.abq0593.
Stainforth, R., Vuong, N., Adam, N., Kuo, B., Wilkins, R.C., Yauk, C., Beheshti, A., & Chauhan, V. (2022). Benchmark dose modeling of transcriptional data: a systematic approach to identify best practices for study designs used in radiation research. Int J Radiat Biol, 98(12), 1832-1844.Taylor & Francis. doi: 10.1080/09553002.2022.2110300.
Vitry, G., Finch, R., Mcstay, G., Behesti, A., Déjean, S., Larose, T., Wotring, V., & da Silveira, W.A. (2022). Muscle atrophy phenotype gene expression during spaceflight is linked to a metabolic crosstalk in both the liver and the muscle in mice. iScience, 25(10), 105213.Elsevier. doi: 10.1016/j.isci.2022.105213.
Yerukala Sathipati, S., Tsai, M.J., Carter, T., Allaire, P., Shukla, S.K., Beheshti, A., & Ho, S.Y. (2022). Survival estimation in patients with stomach and esophageal carcinoma using miRNA expression profiles. Comput Struct Biotechnol J, 20, 4490-4500.American Association for the Advancement of Science (AAAS). doi: 10.1016/j.csbj.2022.08.025.
Yerukala Sathipati, S., Tsai, M.J., Shukla, S.K., Ho, S.Y., Liu, Y., & Beheshti, A. (2022). Author Correction: MicroRNA signature for estimating the survival time in patients with bladder urothelial carcinoma. Sci Rep, 12(1), 4990.Springer Nature. doi: 10.1038/s41598-022-09235-4.
Yerukala Sathipati, S., Tsai, M.J., Shukla, S.K., Ho, S.Y., Liu, Y., & Beheshti, A. (2022). MicroRNA signature for estimating the survival time in patients with bladder urothelial carcinoma. Sci Rep, 12(1), 4141.Springer Nature. doi: 10.1038/s41598-022-08082-7.
Afshinnekoo, E., Scott, R.T., MacKay, M.J., Pariset, E., Cekanaviciute, E., Barker, R., Gilroy, S., Hassane, D., Smith, S.M., Zwart, S.R., Nelman-Gonzalez, M., Crucian, B.E., Ponomarev, S.A., Orlov, O.I., Shiba, D., Muratani, M., Yamamoto, M., Richards, S.E., Vaishampayan, P.A., Meydan, C., Foox, J., Myrrhe, J., Istasse, E., Singh, N., Venkateswaran, K., Keune, J.A., Ray, H.E., Basner, M., Miller, J., Vitaterna, M.H., Taylor, D.M., Wallace, D., Rubins, K., Bailey, S.M., Grabham, P., Costes, S.V., Mason, C.E., & Beheshti, A. (2021). Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration. Cell, 184(24), 6002.Elsevier. doi: 10.1016/j.cell.2021.11.008.
Beheshti, A., McDonald, J.T., Hada, M., Takahashi, A., Mason, C.E., & Mognato, M. (2021). Genomic Changes Driven by Radiation-Induced DNA Damage and Microgravity in Human Cells. Int J Mol Sci, 22(19).MDPI. doi: 10.3390/ijms221910507.
Esposito, A., Casiraghi, E., Chiaraviglio, F., Scarabelli, A., Stellato, E., Plensich, G., Lastella, G., Di Meglio, L., Fusco, S., Avola, E., Jachetti, A., Giannitto, C., Malchiodi, D., Frasca, M., Beheshti, A., Robinson, P.N., Valentini, G., Forzenigo, L., & Carrafiello, G. (2021). Artificial Intelligence in Predicting Clinical Outcome in COVID-19 Patients from Clinical, Biochemical and a Qualitative Chest X-Ray Scoring System. Reports in Medical Imaging, 14(0), 27-39.Taylor & Francis. doi: 10.2147/rmi.s292314.
Haendel, M.A., Chute, C.G., Bennett, T.D., Eichmann, D.A., Guinney, J., Kibbe, W.A., Payne, P.R.O., Pfaff, E.R., Robinson, P.N., Saltz, J.H., Spratt, H., Suver, C., Wilbanks, J., Wilcox, A.B., Williams, A.E., Wu, C., Blacketer, C., Bradford, R.L., Cimino, J.J., Clark, M., Colmenares, E.W., Francis, P.A., Gabriel, D., Graves, A., Hemadri, R., Hong, S.S., Hripscak, G., Jiao, D., Klann, J.G., Kostka, K., Lee, A.M., Lehmann, H.P., Lingrey, L., Miller, R.T., Morris, M., Murphy, S.N., Natarajan, K., Palchuk, M.B., Sheikh, U., Solbrig, H., Visweswaran, S., Walden, A., Walters, K.M., Weber, G.M., Zhang, X.T., Zhu, R.L., Amor, B., Girvin, A.T., Manna, A., Qureshi, N., Kurilla, M.G., Michael, S.G., Portilla, L.M., Rutter, J.L., Austin, C.P., Gersing, K.R., & N3C Consortium. (2021). The National COVID Cohort Collaborative (N3C): Rationale, design, infrastructure, and deployment. J Am Med Inform Assoc, 28(3), 427-443.Oxford University Press (OUP). doi: 10.1093/jamia/ocaa196.
Karlebach, G., Aronow, B., Baylin, S.B., Butler, D., Foox, J., Levy, S., Meydan, C., Mozsary, C., Saravia-Butler, A.M., Taylor, D.M., Wurtele, E., Mason, C.E., Beheshti, A., & Robinson, P.N. (2021). Betacoronavirus-specific alternate splicing. In bioRxiv. doi: 10.1101/2021.07.02.450920.
McDonald, J.T., Enguita, F.J., Taylor, D., Griffin, R.J., Priebe, W., Emmett, M.R., Sajadi, M.M., Harris, A.D., Clement, J., Dybas, J.M., Aykin-Burns, N., Guarnieri, J.W., Singh, L.N., Grabham, P., Baylin, S.B., Yousey, A., Pearson, A.N., Corry, P.M., Saravia-Butler, A., Aunins, T.R., Sharma, S., Nagpal, P., Meydan, C., Foox, J., Mozsary, C., Cerqueira, B., Zaksas, V., Singh, U., Wurtele, E.S., Costes, S.V., Davanzo, G.G., Galeano, D., Paccanaro, A., Meinig, S.L., Hagan, R.S., Bowman, N.M., UNC COVID-19 Pathobiology Consortium, Wolfgang, M.C., Altinok, S., Sapoval, N., Treangen, T.J., Moraes-Vieira, P.M., Vanderburg, C., Wallace, D.C., Schisler, J., Mason, C.E., Chatterjee, A., Meller, R., & Beheshti, A. (2021). The Great Deceiver: miR-2392's Hidden Role in Driving SARS-CoV-2 Infection. bioRxiv, 2021.04.23.441024.Cold Spring Harbor Laboratory. doi: 10.1101/2021.04.23.441024.
McDonald, J.T., Enguita, F.J., Taylor, D., Griffin, R.J., Priebe, W., Emmett, M.R., Sajadi, M.M., Harris, A.D., Clement, J., Dybas, J.M., Aykin-Burns, N., Guarnieri, J.W., Singh, L.N., Grabham, P., Baylin, S.B., Yousey, A., Pearson, A.N., Corry, P.M., Saravia-Butler, A., Aunins, T.R., Sharma, S., Nagpal, P., Meydan, C., Foox, J., Mozsary, C., Cerqueira, B., Zaksas, V., Singh, U., Wurtele, E.S., Costes, S.V., Davanzo, G.G., Galeano, D., Paccanaro, A., Meinig, S.L., Hagan, R.S., Bowman, N.M., UNC COVID-19 Pathobiology Consortium, Wolfgang, M.C., Altinok, S., Sapoval, N., Treangen, T.J., Moraes-Vieira, P.M., Vanderburg, C., Wallace, D.C., Schisler, J.C., Mason, C.E., Chatterjee, A., Meller, R., & Beheshti, A. (2021). Role of miR-2392 in driving SARS-CoV-2 infection. Cell Rep, 37(3), 109839.Elsevier. doi: 10.1016/j.celrep.2021.109839.
Nguyen, H., Tran, D., Galazka, J.M., Costes, S.V., Beheshti, A., Petereit, J., Draghici, S., & Nguyen, T. (2021). CPA: a web-based platform for consensus pathway analysis and interactive visualization. Nucleic Acids Res, 49(W1), W114-W124.Oxford University Press (OUP). doi: 10.1093/nar/gkab421.
Overbey, E.G., Saravia-Butler, A.M., Zhang, Z., Rathi, K.S., Fogle, H., da Silveira, W.A., Barker, R.J., Bass, J.J., Beheshti, A., Berrios, D.C., Blaber, E.A., Cekanaviciute, E., Costa, H.A., Davin, L.B., Fisch, K.M., Gebre, S.G., Geniza, M., Gilbert, R., Gilroy, S., Hardiman, G., Herranz, R., Kidane, Y.H., Kruse, C.P.S., Lee, M.D., Liefeld, T., Lewis, N.G., McDonald, J.T., Meller, R., Mishra, T., Perera, I.Y., Ray, S., Reinsch, S.S., Rosenthal, S.B., Strong, M., Szewczyk, N.J., Tahimic, C.G.T., Taylor, D.M., Vandenbrink, J.P., Villacampa, A., Weging, S., Wolverton, C., Wyatt, S.E., Zea, L., Costes, S.V., & Galazka, J.M. (2021). NASA GeneLab RNA-seq consensus pipeline: standardized processing of short-read RNA-seq data. iScience, 24(4), 102361.Elsevier. doi: 10.1016/j.isci.2021.102361.
Park, J., Foox, J., Hether, T., Danko, D., Warren, S., Kim, Y., Reeves, J., Butler, D.J., Mozsary, C., Rosiene, J., Shaiber, A., Afshinnekoo, E., MacKay, M., Bram, Y., Chandar, V., Geiger, H., Craney, A., Velu, P., Melnick, A.M., Hajirasouliha, I., Beheshti, A., Taylor, D., Saravia-Butler, A., Singh, U., Wurtele, E.S., Schisler, J., Fennessey, S., Corvelo, A., Zody, M.C., Germer, S., Salvatore, S., Levy, S., Wu, S., Tatonetti, N., Shapira, S., Salvatore, M., Loda, M., Westblade, L.F., Cushing, M., Rennert, H., Kriegel, A.J., Elemento, O., Imielinski, M., Borczuk, A.C., Meydan, C., Schwartz, R.E., & Mason, C.E. (2021). Systemic Tissue and Cellular Disruption from SARS-CoV-2 Infection revealed in COVID-19 Autopsies and Spatial Omics Tissue Maps. In bioRxiv. doi: 10.1101/2021.03.08.434433.
Ravi, D., Beheshti, A., Abermil, N., Lansigan, F., Kinlaw, W., Matthan, N.R., Mokhtar, M., Passero, F.C., Puliti, P., David, K.A., Dolnikowski, G.G., Su, X., Chen, Y., Bijan, M., Varshney, R.R., Kim, B., Dave, S.S., Rudolph, M.C., & Evens, A.M. (2021). Oncogenic Integration of Nucleotide Metabolism via Fatty Acid Synthase in Non-Hodgkin Lymphoma. Front Oncol, 11, 725137.Frontiers. doi: 10.3389/fonc.2021.725137.
Sapoval, N., Mahmoud, M., Jochum, M.D., Liu, Y., Elworth, R.A.L., Wang, Q., Albin, D., Ogilvie, H.A., Lee, M.D., Villapol, S., Hernandez, K.M., Maljkovic Berry, I., Foox, J., Beheshti, A., Ternus, K., Aagaard, K.M., Posada, D., Mason, C.E., Sedlazeck, F.J., & Treangen, T.J. (2021). SARS-CoV-2 genomic diversity and the implications for qRT-PCR diagnostics and transmission. Genome Res, 31(4), 635-644.Cold Spring Harbor Laboratory. doi: 10.1101/gr.268961.120.
Afshinnekoo, E., Scott, R.T., MacKay, M.J., Pariset, E., Cekanaviciute, E., Barker, R., Gilroy, S., Hassane, D., Smith, S.M., Zwart, S.R., Nelman-Gonzalez, M., Crucian, B.E., Ponomarev, S.A., Orlov, O.I., Shiba, D., Muratani, M., Yamamoto, M., Richards, S.E., Vaishampayan, P.A., Meydan, C., Foox, J., Myrrhe, J., Istasse, E., Singh, N., Venkateswaran, K., Keune, J.A., Ray, H.E., Basner, M., Miller, J., Vitaterna, M.H., Taylor, D.M., Wallace, D., Rubins, K., Bailey, S.M., Grabham, P., Costes, S.V., Mason, C.E., & Beheshti, A. (2020). Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration. Cell, 183(5), 1162-1184.Elsevier. doi: 10.1016/j.cell.2020.10.050.
Beheshti, A., Chakravarty, K., Fogle, H., Fazelinia, H., Silveira, W.A.D., Boyko, V., Polo, S.H.L., Saravia-Butler, A.M., Hardiman, G., Taylor, D., Galazka, J.M., & Costes, S.V. (2020). Author Correction: Multi-omics analysis of multiple missions to space reveal a theme of lipid dysregulation in mouse liver. Sci Rep, 10(1), 1517.Springer Nature. doi: 10.1038/s41598-020-58490-w.
da Silveira, W., Fazelinia, H., Rosenthal, S.B., Laiakis, E., Meydan, C., Kidane, Y., Smith, S.M., Rathi, K.S., Foox, J., Zanello, S., Crucian, B., Wang, D., Nugent, A., Costa, H., Zwart, S., Schrepfer, S., Elworth, R.A.L., Sapoval, N., Treangen, T., Schisler, J.C., Gokhale, N.S., Horner, S., Singh, L., Wallace, D., Willey, J., Meller, R., McDonald, J.T., Fisch, K., Taylor, D., Hardiman, G., Mason, C.E., Costes, S.V., & Beheshti, A. (2020). Multi-Omics Analysis Reveals Mitochondrial Stress as a Central Hub for Spaceflight Biological Impact. SSRN Electronic Journal.Elsevier. doi: 10.2139/ssrn.3624420.
da Silveira, W.A., Fazelinia, H., Rosenthal, S.B., Laiakis, E.C., Kim, M.S., Meydan, C., Kidane, Y., Rathi, K.S., Smith, S.M., Stear, B., Ying, Y., Zhang, Y., Foox, J., Zanello, S., Crucian, B., Wang, D., Nugent, A., Costa, H.A., Zwart, S.R., Schrepfer, S., Elworth, R.A.L., Sapoval, N., Treangen, T., MacKay, M., Gokhale, N.S., Horner, S.M., Singh, L.N., Wallace, D.C., Willey, J.S., Schisler, J.C., Meller, R., McDonald, J.T., Fisch, K.M., Hardiman, G., Taylor, D., Mason, C.E., Costes, S.V., & Beheshti, A. (2020). Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact. Cell, 183(5), 1185-1201.e20.Elsevier. doi: 10.1016/j.cell.2020.11.002.
Malkani, S., Cekanaviciute, E., Mortreux, M., Okunola, H., Tarbier, M., Schreurs, A.S., Shirazi-Fard, Y., Tahimic, C.G.T., Cheng-Campbell, M., Blaber, E.A., Vanderburg, C., Friedländer, M.R., McDonald, J.T., Costes, S.V., Mason, C.E., Rutkove, S., Grabham, P., & Beheshti, A. (2020). Circulating miRNA Signature Predicts and Rescues Spaceflight Associated Health Risks. SSRN Electronic Journal.Elsevier. doi: 10.2139/ssrn.3641936.
Malkani, S., Chin, C.R., Cekanaviciute, E., Mortreux, M., Okinula, H., Tarbier, M., Schreurs, A.S., Shirazi-Fard, Y., Tahimic, C.G.T., Rodriguez, D.N., Sexton, B.S., Butler, D., Verma, A., Bezdan, D., Durmaz, C., MacKay, M., Melnick, A., Meydan, C., Li, S., Garrett-Bakelman, F., Fromm, B., Afshinnekoo, E., Langhorst, B.W., Dimalanta, E.T., Cheng-Campbell, M., Blaber, E., Schisler, J.C., Vanderburg, C., Friedländer, M.R., McDonald, J.T., Costes, S.V., Rutkove, S., Grabham, P., Mason, C.E., & Beheshti, A. (2020). Circulating miRNA Spaceflight Signature Reveals Targets for Countermeasure Development. Cell Rep, 33(10), 108448.Elsevier. doi: 10.1016/j.celrep.2020.108448.
McDonald, J.T., Stainforth, R., Miller, J., Cahill, T., da Silveira, W.A., Rathi, K.S., Hardiman, G., Taylor, D., Costes, S.V., Chauhan, V., Meller, R., & Beheshti, A. (2020). NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models. Cancers (Basel), 12(2).MDPI. doi: 10.3390/cancers12020381.
Overbey, E.G., Saravia-Butler, A.M., Zhang, Z., Rathi, K.S., Fogle, H., da Silveira, W.A., Barker, R.J., Bass, J.J., Beheshti, A., Berrios, D.C., Blaber, E.A., Cekanaviciute, E., Costa, H.A., Davin, L.B., Fisch, K.M., Gebre, S.G., Geniza, M., Gilbert, R., Gilroy, S., Hardiman, G., Herranz, R., Kidane, Y.H., Kruse, C.P.S., Lee, M.D., Liefeld, T., Lewis, N.G., McDonald, J.T., Meller, R., Mishra, T., Perera, I.Y., Ray, S., Reinsch, S.S., Rosenthal, S.B., Strong, M., Szewczyk, N.J., Tahimic, C.G.T., Taylor, D.M., Vandenbrink, J.P., Villacampa, A., Weging, S., Wolverton, C., Wyatt, S.E., Zea, L., Costes, S.V., & Galazka, J.M. (2020). NASA GeneLab RNA-Seq Consensus Pipeline: Standardized Processing of Short-Read RNA-Seq Data. In bioRxiv. doi: 10.1101/2020.11.06.371724.
Passero, F.C., Ravi, D., McDonald, J.T., Beheshti, A., David, K.A., & Evens, A.M. (2020). Combinatorial ixazomib and belinostat therapy induces NFE2L2-dependent apoptosis in Hodgkin and T-cell lymphoma. Br J Haematol, 188(2), 295-308.Wiley. doi: 10.1111/bjh.16160.
Paul, A.M., Cheng-Campbell, M., Blaber, E.A., Anand, S., Bhattacharya, S., Zwart, S., Crucian, B., Smith, S.M., Meller, R., Grabham, P., & Beheshti, A. (2020). Beyond Low-Earth Orbit: Characterizing the Immune Profile Following Simulated Spaceflight Conditions for Deep Space Missions. SSRN Electronic Journal.Elsevier. doi: 10.2139/ssrn.3639610.
Paul, A.M., Cheng-Campbell, M., Blaber, E.A., Anand, S., Bhattacharya, S., Zwart, S.R., Crucian, B.E., Smith, S.M., Meller, R., Grabham, P., & Beheshti, A. (2020). Beyond Low-Earth Orbit: Characterizing Immune and microRNA Differentials following Simulated Deep Spaceflight Conditions in Mice. iScience, 23(12), 101747.Elsevier. doi: 10.1016/j.isci.2020.101747.
Ravi, D., Sarkar, S., Purvey, S., Passero, F., Beheshti, A., Chen, Y., Mokhtar, M., David, K., Konry, T., & Evens, A.M. (2020). Interaction kinetics with transcriptomic and secretory responses of CD19-CAR natural killer-cell therapy in CD20 resistant non-hodgkin lymphoma. Leukemia, 34(5), 1291-1304.Springer Nature. doi: 10.1038/s41375-019-0663-x.
Sapoval, N., Mahmoud, M., Jochum, M.D., Liu, Y., Elworth, R.A.L., Wang, Q., Albin, D., Ogilvie, H., Lee, M.D., Villapol, S., Hernandez, K.M., Berry, I.M., Foox, J., Beheshti, A., Ternus, K., Aagaard, K.M., Posada, D., Mason, C.E., Sedlazeck, F., & Treangen, T.J. (2020). Hidden genomic diversity of SARS-CoV-2: implications for qRT-PCR diagnostics and transmission. In bioRxiv. doi: 10.1101/2020.07.02.184481.
Wuu, Y.R., Hu, B., Okunola, H., Paul, A.M., Blaber, E.A., Cheng-Campbell, M., Beheshti, A., & Grabham, P. (2020). LET-Dependent Low Dose and Synergistic Inhibition of Human Angiogenesis by Charged Particles: Validation of miRNAs that Drive Inhibition. iScience, 23(12), 101771.Elsevier. doi: 10.1016/j.isci.2020.101771.
Wuu, Y.R., Hu, B., Okunola, H., Paul, A.M., Blaber, E.A., Cheng-Campbell, M., Beheshti, A., & Grabham, P. (2020). LET Dependent Low Dose and Synergistic Inhibition of Human Angiogenesis by Charged Particles: Validation of Mi RNAs that Drive Inhibition. SSRN Electronic Journal.Elsevier. doi: 10.2139/ssrn.3671930.
Beheshti, A., Chakravarty, K., Fogle, H., Fazelinia, H., Silveira, W.A.D., Boyko, V., Polo, S.H.L., Saravia-Butler, A.M., Hardiman, G., Taylor, D., Galazka, J.M., & Costes, S.V. (2019). Multi-omics analysis of multiple missions to space reveal a theme of lipid dysregulation in mouse liver. Sci Rep, 9(1), 19195.Springer Nature. doi: 10.1038/s41598-019-55869-2.
Beheshti, A., McDonald, J.T., Miller, J., Grabham, P., & Costes, S.V. (2019). GeneLab Database Analyses Suggest Long-Term Impact of Space Radiation on the Cardiovascular System by the Activation of FYN Through Reactive Oxygen Species. Int J Mol Sci, 20(3).MDPI. doi: 10.3390/ijms20030661.
Beheshti, A., Shirazi-Fard, Y., Choi, S., Berrios, D., Gebre, S.G., Galazka, J.M., & Costes, S.V. (2019). Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform. J Vis Exp, (143).MyJove. doi: 10.3791/58447.
Beheshti, A., Stevenson, K., Vanderburg, C., Ravi, D., McDonald, J.T., Christie, A.L., Shigemori, K., Jester, H., Weinstock, D.M., & Evens, A.M. (2019). Identification of Circulating Serum Multi-MicroRNA Signatures in Human DLBCL Models. Sci Rep, 9(1), 17161.Springer Nature. doi: 10.1038/s41598-019-52985-x.
Beheshti, A., Cekanaviciute, E., Smith, D.J., & Costes, S.V. (2018). Global transcriptomic analysis suggests carbon dioxide as an environmental stressor in spaceflight: A systems biology GeneLab case study. Sci Rep, 8(1), 4191.Springer Nature. doi: 10.1038/s41598-018-22613-1.
Beheshti, A., Miller, J., Kidane, Y., Berrios, D., Gebre, S.G., & Costes, S.V. (2018). NASA GeneLab Project: Bridging Space Radiation Omics with Ground Studies. Radiat Res, 189(6), 553-559.Radiation Research Society. doi: 10.1667/RR15062.1.
Beheshti, A., Ray, S., Fogle, H., Berrios, D., & Costes, S.V. (2018). A microRNA signature and TGF-β1 response were identified as the key master regulators for spaceflight response. In van Wijnen, A. (Ed.). PLoS One, 13(7), e0199621.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0199621.
Berrios, D.C., Beheshti, A., & Costes, S.V. (2018). FAIRness and Usability for Open-access Omics Data Systems. AMIA Annu Symp Proc, 2018, 232-241.
Bhalla, K., Jaber, S., Nahid M, N., Underwood, K., Beheshti, A., Landon, A., Bhandary, B., Bastian, P., Evens, A.M., Haley, J., Polster, B., & Gartenhaus, R.B. (2018). Role of hypoxia in Diffuse Large B-cell Lymphoma: Metabolic repression and selective translation of HK2 facilitates development of DLBCL. Sci Rep, 8(1), 744.Springer Nature. doi: 10.1038/s41598-018-19182-8.
Bhalla, K., Jaber, S., Nahid M, N., Underwood, K., Beheshti, A., Landon, A., Bhandary, B., Bastian, P., Evens, A.M., Haley, J., Polster, B., & Gartenhaus, R.B. (2018). Author Correction: Role of hypoxia in Diffuse Large B-cell Lymphoma: Metabolic repression and selective translation of HK2 facilitates development of DLBCL. Sci Rep, 8(1), 7221.Springer Nature. doi: 10.1038/s41598-018-25251-9.
Cortese, F., Klokov, D., Osipov, A., Stefaniak, J., Moskalev, A., Schastnaya, J., Cantor, C., Aliper, A., Mamoshina, P., Ushakov, I., Sapetsky, A., Vanhaelen, Q., Alchinova, I., Karganov, M., Kovalchuk, O., Wilkins, R., Shtemberg, A., Moreels, M., Baatout, S., Izumchenko, E., de Magalhães, J.P., Artemov, A.V., Costes, S.V., Beheshti, A., Mao, X.W., Pecaut, M.J., Kaminskiy, D., Ozerov, I.V., Scheibye-Knudsen, M., & Zhavoronkov, A. (2018). Vive la radiorésistance!: converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization. Oncotarget, 9(18), 14692-14722.Impact Journals. doi: 10.18632/oncotarget.24461.
Kapadia, B., Nanaji, N.M., Bhalla, K., Bhandary, B., Lapidus, R., Beheshti, A., Evens, A.M., & Gartenhaus, R.B. (2018). Fatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL. Nat Commun, 9(1), 829.Springer Nature. doi: 10.1038/s41467-018-03028-y.
McDonald, J.T., Kritharis, A., Beheshti, A., Pilichowska, M., Burgess, K., Ricks-Santi, L., McNiel, E., London, C.A., Ravi, D., & Evens, A.M. (2018). Correction: Comparative oncology DNA sequencing of canine T cell lymphoma via human hotspot panel. Oncotarget, 9(70), 33441.Impact Journals. doi: 10.18632/oncotarget.26114.
McDonald, J.T., Kritharis, A., Beheshti, A., Pilichowska, M., Burgess, K., Ricks-Santi, L., McNiel, E., London, C.A., Ravi, D., & Evens, A.M. (2018). Comparative oncology DNA sequencing of canine T cell lymphoma via human hotspot panel. Oncotarget, 9(32), 22693-22702.Impact Journals. doi: 10.18632/oncotarget.25209.
Beheshti, A., Vanderburg, C., McDonald, J.T., Ramkumar, C., Kadungure, T., Zhang, H., Gartenhaus, R.B., & Evens, A.M. (2017). A Circulating microRNA Signature Predicts Age-Based Development of Lymphoma. In Zhao, J. (Ed.). PLoS One, 12(1), e0170521.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0170521.
Sarkar, S., Sabhachandani, P., Ravi, D., Potdar, S., Purvey, S., Beheshti, A., Evens, A.M., & Konry, T. (2017). Dynamic Analysis of Human Natural Killer Cell Response at Single-Cell Resolution in B-Cell Non-Hodgkin Lymphoma. Front Immunol, 8, 1736.Frontiers. doi: 10.3389/fimmu.2017.01736.
Ravi, D., Beheshti, A., Abermil, N., Passero, F., Sharma, J., Coyle, M., Kritharis, A., Kandela, I., Hlatky, L., Sitkovsky, M.V., Mazar, A., Gartenhaus, R.B., & Evens, A.M. (2016). Proteasomal Inhibition by Ixazomib Induces CHK1 and MYC-Dependent Cell Death in T-cell and Hodgkin Lymphoma. Cancer Res, 76(11), 3319-3331.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-15-2477.
Beheshti, A., Benzekry, S., McDonald, J.T., Ma, L., Peluso, M., Hahnfeldt, P., & Hlatky, L. (2015). Host age is a systemic regulator of gene expression impacting cancer progression. Cancer Res, 75(6), 1134-1143.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-14-1053.
Beheshti, A., Neuberg, D., McDonald, J.T., Vanderburg, C.R., & Evens, A.M. (2015). The Impact of Age and Sex in DLBCL: Systems Biology Analyses Identify Distinct Molecular Changes and Signaling Networks. Cancer Inform, 14, 141-148.SAGE Publications. doi: 10.4137/CIN.S34144.
Beheshti, A., Wage, J., McDonald, J.T., Lamont, C., Peluso, M., Hahnfeldt, P., & Hlatky, L. (2015). Tumor-host signaling interaction reveals a systemic, age-dependent splenic immune influence on tumor development. Oncotarget, 6(34), 35419-35432.Impact Journals. doi: 10.18632/oncotarget.6214.
Benzekry, S., Beheshti, A., Hahnfeldt, P., & Hlatky, L. (2015). Capturing the Driving Role of Tumor-Host Crosstalk in a Dynamical Model of Tumor Growth. Bio Protoc, 5(21), e1644.Bio-Protocol. doi: 10.21769/bioprotoc.1644.
Suresh Kumar, M.A., Peluso, M., Chaudhary, P., Dhawan, J., Beheshti, A., Manickam, K., Thapar, U., Pena, L., Natarajan, M., Hlatky, L., Demple, B., & Naidu, M. (2015). Fractionated Radiation Exposure of Rat Spinal Cords Leads to Latent Neuro-Inflammation in Brain, Cognitive Deficits, and Alterations in Apurinic Endonuclease 1. In Dal Pizzol, F. (Ed.). PLoS One, 10(7), e0133016.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0133016.
Wage, J., Ma, L., Peluso, M., Lamont, C., Evens, A.M., Hahnfeldt, P., Hlatky, L., & Beheshti, A. (2015). Proton irradiation impacts age-driven modulations of cancer progression influenced by immune system transcriptome modifications from splenic tissue. J Radiat Res, 56(5), 792-803.Oxford University Press (OUP). doi: 10.1093/jrr/rrv043.
Beheshti, A., Peluso, M., Lamont, C., Hahnfeldt, P., & Hlatky, L. (2014). Proton irradiation augments the suppression of tumor progression observed with advanced age. Radiat Res, 181(3), 272-283.Radiation Research Society. doi: 10.1667/RR13538.1.
Benzekry, S., Lamont, C., Beheshti, A., Tracz, A., Ebos, J.M.L., Hlatky, L., & Hahnfeldt, P. (2014). Classical mathematical models for description and prediction of experimental tumor growth. In Mac Gabhann, F. (Ed.). PLoS Comput Biol, 10(8), e1003800.Public Library of Science (PLoS). doi: 10.1371/journal.pcbi.1003800.
Crucian, B.E., Zwart, S.R., Mehta, S., Uchakin, P., Quiriarte, H.D., Pierson, D., Sams, C.F., & Smith, S.M. (2014). Plasma cytokine concentrations indicate that in vivo hormonal regulation of immunity is altered during long-duration spaceflight. J Interferon Cytokine Res, 34(10), 778-786.SAGE Publications. doi: 10.1089/jir.2013.0129.
Almog, N., Briggs, C., Beheshti, A., Ma, L., Wilkie, K.P., Rietman, E., & Hlatky, L. (2013). Transcriptional changes induced by the tumor dormancy-associated microRNA-190. Transcription, 4(4), 177-191.Taylor & Francis. doi: 10.4161/trns.25558.
Beheshti, A., Pinzer, B.R., McDonald, J.T., Stampanoni, M., & Hlatky, L. (2013). Early tumor development captured through nondestructive, high resolution differential phase contrast X-ray imaging. Radiat Res, 180(5), 448-454.Radiation Research Society. doi: 10.1667/RR13327.1.
Beheshti, A., Sachs, R.K., Peluso, M., Rietman, E., Hahnfeldt, P., & Hlatky, L. (2013). Age and space irradiation modulate tumor progression: implications for carcinogenesis risk. Radiat Res, 179(2), 208-220.Radiation Research Society. doi: 10.1667/RR3100.1.
Almog, N., Ma, L., Schwager, C., Brinkmann, B.G., Beheshti, A., Vajkoczy, P., Folkman, J., Hlatky, L., & Abdollahi, A. (2012). Consensus micro RNAs governing the switch of dormant tumors to the fast-growing angiogenic phenotype. In Rota, R. (Ed.). PLoS One, 7(8), e44001.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0044001.
Domhan, S., Ma, L., Tai, A., Anaya, Z., Beheshti, A., Zeier, M., Hlatky, L., & Abdollahi, A. (2011). Intercellular communication by exchange of cytoplasmic material via tunneling nano-tube like structures in primary human renal epithelial cells. In McNeil, P. (Ed.). PLoS One, 6(6), e21283.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0021283.
Girdhani, S., Lamont, C., Hahnfeldt, P., Weremowicz, J., Anaya, Z., Beheshti, A., Abdollahi, A., & Hlatky, L. (2010). Abstract 1319: Proton irradiation exerts antiangiogenic and other tumor progression-limiting effects. Cancer Research, 70(8_Supplement), 1319.American Association for Cancer Research (AACR). doi: 10.1158/1538-7445.am10-1319.
Enderling, H., Anderson, A.R.A., Chaplain, M.A.J., Beheshti, A., Hlatky, L., & Hahnfeldt, P. (2009). Paradoxical dependencies of tumor dormancy and progression on basic cell kinetics. Cancer Res, 69(22), 8814-8821.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-09-2115.
Rill, R.L., Beheshti, A., & Van Winkle, D.H. (2002). DNA electrophoresis in agarose gels: effects of field and gel concentration on the exponential dependence of reciprocal mobility on DNA length. Electrophoresis, 23(16), 2710-2719.Wiley. doi: 10.1002/1522-2683(200208)23:16<2710::AID-ELPS2710>3.0.CO;2-0.
Van, W., Beheshti, A., & Rill, R.L. (2002). DNA electrophoresis in agarose gels: a simple relation describing the length dependence of mobility. Electrophoresis, 23(1), 15-19.Wiley. doi: 10.1002/1522-2683(200201)23:1<15::AID-ELPS15>3.0.CO;2-L.
Jarrahpour, A.A., Alvand, P., Arab, R., & Beheshti, A. Synthesis of β-D galactopyranosyl amino-(N-salicylidene) - 2, 3, 4, 6-tetra-O-acetate as a new chiral Schiff base for asymmetric transformations. Molbank, 2005(4), m435.MDPI. doi: 10.3390/m435.
Jarrahpour, A.A., Alvand, P., Arab, R., & Beheshti, A. Synthesis of N-(2-hydroxy-3-methoxybenzylidene) - 2, 3, 4, 6-tetra-O-acetyl -β-D galactopyranosylamine as a new chiral Schiff base for asymmetric [2+2] cycloadditions. Molbank, 2005(4), m436.MDPI. doi: 10.3390/m436.

Anu I, R., Borg, J., Kim, J., Larose, T., Scott, R.T., Borg, J., Mason, C.E., Beheshti, A., & van der Speeten, K. (2026). Signaling pathway insights into spaceflight cancer risks. In CANCER RESEARCH, 86(7).American Association for Cancer Research (AACR). doi: 10.1158/1538-7445.AM2026-5273.
Georgakoudi, I., Polleys, C., Singh, P., Thieu, H.T., Genega, E., Jahanseir, N., Zuckerman, A., Diaz, F.R., Patra, A., & Beheshti, A. (2025). Precision pre-cancer detection via functional metabolic heterogeneity metrics from label-free, high resolution tissue fluorescence and transcriptomic data. In CANCER RESEARCH, 85(5).American Association for Cancer Research (AACR). doi: 10.1158/1538-7445.GENFUNC25-A009.
Chia, S.B., Johnson, B.J., Hu, J., Vermeulen, R., Chadeau-Hyam, M., Guntoro, F., Montgomery, H., Boorgula, M., Sreekanth, V., Goodspeed, A., Davenport, B., Valenca-Pereira, F., Zaberezhnyy, V., Schleicher, W.E., Gao, D., Cadar, A.N., Papanicolaou, M., Beheshti, A., Baylin, S.B., Costello, J., Bartley, J.M., Morrison, T.E., Aguirre-Ghiso, J.A., Rincon, M., & DeGregori, J. (2024). Respiratory viral infection promotes the awakening and outgrowth of dormant metastatic breast cancer cells in lungs. In CANCER RESEARCH, 84(22).American Association for Cancer Research (AACR). doi: 10.1158/1538-7445.TUMBODY-IA007.
Mathyk, B., Guzeloglu-Kayisli, O., Guarnieri, J.W., Tabetah, M., Gabrielle, W., Cen, Z., Mason, C., Beheshti, A., & Kayisli, U. (2024). Understanding the Interplay of Preeclampsia and Spaceflight. In REPRODUCTIVE SCIENCES, 31, (p. 319A).
Warren, E., Franco, J.M., Beheshti, A., & McGuire, P. (2024). Oxidative metabolism induces differential miRNA expression in mitochondrial disease LCLS. In MOLECULAR GENETICS AND METABOLISM, 141(4).Elsevier. doi: 10.1016/j.ymgme.2024.108201.
Bodi, N., Miller, R., Hameed, S., Kubik, A., Allen, N., Altinok, S., Oswalt, L., Sanchez-Hodge, R., Schisler, J., Blaber, E., Beheshti, A., & Sharma, T. (2023). Altered DNA damage and stress pathways in antagomir-treated rodent spaceflight analogs. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 64(8).
Jirak, P., Paar, V., Jiang, S., Enriquez, A., Keun, J.J., Brunetta, H.S., Muratani, M., Kubik, A., Allen, N., Blaber, E., Overbey, E., Altinok, S., Sanchez-Hodge, R., Oswalt, L.E., Kaufman, B., Mori, M.A., Motloch, L.J., Mason, C.E., Schisler, J.C., & Beheshti, A. (2023). Countermeasures for cardiac fibrosis in space travel: It takes more than a towel for a hitchhiker's guide to the galaxy. In WIENER KLINISCHE WOCHENSCHRIFT, 135, (pp. S334-S336).
Snapper, D., Reginauld, B., Liaudanskaya, V., Fitzpatrick, V., Kim, Y., Frank, A., Beheshti, A., Vorn, R.R., Gill, J., Georgakoudi, I., Kaplan, D., & Symes, A. (2023). IDENTIFYING BIOMARKERS OF PRIMARY BLASTINDUCED TRAUMATIC BRAIN INJURY USING A NOVEL BIOENGINEERED 3D BRAIN-LIKE TISSUE. In JOURNAL OF NEUROTRAUMA, 40(15-16), (pp. A60-A61).
Mathyk, A.B., Alvarado, F., Young, S.L., Beheshti, A., & Quaas, A.M. (2022). EFFECTS OF SPACEFLIGHT ON ESTROGEN RECEPTOR EXPRESSION AND SIGNALING. In FERTILITY AND STERILITY, 118(5), (p. E21).
Sharma, T.P., Miller, R.C.S., ShahulHameed, S.P., Kubik, A., Allen, N., Altinok, S., Oswalt, L.E., Sanchez-Hodge, R., Schisler, J.C., Blaber, E., & Beheshti, A. (2022). Spaceflight-Associated miRNAs Alters Expression of Targeted Genes in Ocular and Spinal Tissue Under Simulated Spaceflight Conditions. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 63(7).
Mathyk, B.A., Alvarado, F., Young, S.L., Quaas, A.M., & Beheshti, A. (2021). EXPRESSION OF INSULIN RESISTANCE RELATED GENES DURING SPACEFLIGHT. In FERTILITY AND STERILITY, 116(3), (p. E107).
Paul, A.M., Cheng-Campbell, M., Blaber, E.A., Anand, S., Bhattacharya, S., Zwart, S.R., Crucian, B.E., Smith, S.M., Meller, R., Grabham, P., & Beheshti, A. (2021). Immune and microRNA differentials post-simulated deep spaceflight. In JOURNAL OF IMMUNOLOGY, 206.
Berrios, D., Weitz, E., Grigorev, K., Costes, S., Gebre, S., & Beheshti, A. (2020). Visualizing Omics Data from Spaceflight Samples using the NASA GeneLab Platform. In EPiC series in computing, 70, (pp. 89-78).EasyChair. doi: 10.29007/rh7n.
Beheshti, M., Manafi-Farid, R., Beheshti, A., Wundsam, H., Mottaghy, F.M., Geinitz, H., & Langsteger, W. (2019). Impact of 18F-FDG PET/CT comparing to MRI in primary staging and treatment approach of anal cancer. In EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 46(SUPPL 1), (pp. S335-S336).
Dashnamoorthy, R., Beheshti, A., Su, X., Chen, Y., Mokhtar, M., Dolnikowski, G., Lansigan, F., Kinlaw, W.B.I.I.I., Dave, S., & Evens, A.M. (2019). Identification of FASN-Dependent Onco-Metabolic Regulation of the Pentose Phosphate Pathway (PPP) and Nucleotide Metabolism in Non-Hodgkin Lymphoma (NHL). In BLOOD, 134(Supplement_1).American Society of Hematology. doi: 10.1182/blood-2019-126382.
Dashnamoorthy, R., Sarkar, S., Beheshti, A., Mokhtar, M., Konry, T., Levin, M., & Evens, A.M. (2019). Transcriptomic and Metabolomic Profiling Identifies Calcium-Dependent Signaling Mechanisms As a Novel and Exploitable Target to Overcome Anti-CD20 Resistance in Non-Hodgkin Lymphoma (NHL). In BLOOD, 134(Supplement_1).American Society of Hematology. doi: 10.1182/blood-2019-126539.
Beheshti, A., Stevenson, K.E., Dashnamoorthy, R., Vanderburg, C., Weinstock, D.M., & Evens, A.M. (2018). Ultra-Sensitive Detection of Circulating Serum microRNAs (miRNAs) in Diffuse Large B-Cell Lymphoma (DLBCL) Patient-Derived Xenograft (PDX) Models and Correlation with Disease Status in DLBCL Patient. In BLOOD, 132(Supplement 1).American Society of Hematology. doi: 10.1182/blood-2018-99-116789.
Dashnamoorthy, R., Beheshti, A., Cass, S., Kritharis, A., Burgess, K., London, C., & Evens, A.M. (2018). Transcriptomic Systems Biology Analyses with Buparlisib (BKM120) Pan PI3K Inhibition in Canine B Cell Lymphoma (BCL): Leveraging Comparative Oncology for Cancer Therapeutics and Biomarker Discovery. In BLOOD, 132(Supplement 1).American Society of Hematology. doi: 10.1182/blood-2018-99-118548.
Dashnamoorthy, R., Beheshti, A., Sarkar, S., Konry, T., Levin, M., & Evens, A.M. (2018). System Biology Analysis to Delineate Mechanisms of Anti-CD20 Antibody Resistance in Non-Hodgkin Lymphoma (NHL): Influence of BCR Signaling and the Critical Importance of Calcium Polarization. In BLOOD, 132(Supplement 1).American Society of Hematology. doi: 10.1182/blood-2018-99-118787.
Beheshti, A., Vanderburg, C., Dashnamoorthy, R., McDonald, J.T., Christie, A.L., Shigemori, K., Jester, H., Zhang, H., Weinstock, D.M., & Evens, A.M. (2017). Circulating Micrornas (miRNA) As a Novel Liquid Biopsy and Therapeutic Platform in MYC and Non-MYC Diffuse Large B-Cell Lymphoma (DLBCL). In BLOOD, 130.
Dashnamoorthy, R., Chen, B., Galera, P., Chang, H., Beheshti, A., Ghosh, S., & Evens, A.M. (2017). The Immune Checkpoint Receptors PD-1, PD-L1, TIM-3 and LAG-3 in Lymphoma: Tumor Cell and Tumor Infiltrating Lymphocyte (TIL) Expression, Patient Prognostication, and Identification of Rational Therapeutic Targets. In BLOOD, 130.
Dashnamoorthy, R., Sarkar, S., Sabachandani, P., Purvey, S., Beheshti, A., Konry, T., & Evens, A.M. (2017). Harnessing Microfluidic Single Cell (MF-SC) and 3D "Organ-on-Chip" Assay Technologies for the Investigation of Immunotherapy and Study of Tumor Microenvironment (TME) in Antibody-Resistant Non-Hodgkin Lymphoma (NHL). In BLOOD, 130.
Purvey, S., Dashnamoorthy, R., Beheshti, A., Klein, A., Boissel, L., Sarkar, S., Konry, T., & Evens, A.M. (2017). CD19-Chimeric Antigen Receptor (CAR) Engineered Natural Killer (NK) Cell Therapy: Novel "Off the Shelf" Immunotherapy in CD20 Resistant B-Cell Non-Hodgkin Lymphoma (NHL) Cell Lines, Primary NHL Cells, and a Human Lymphoma Xenograft Model. In BLOOD, 130.
Beheshti, A., Coyle, M.E., Dashnamoorthy, R., & Evens, A.M. (2016). Buparlisib/BKM120 PI3 Kinase Therapy in B Cell and T Cell Non-Hodgkin Lymphoma (NHL) and Hodgkin Lymphoma (HL): Identification of Resistance Pathways and Biomarker Discovery. In BLOOD, 128(22).American Society of Hematology. doi: 10.1182/blood.V128.22.2920.2920.
Beheshti, A., Vanderburg, C., Mcdonald, J.T., Zhang, H., & Evens, A.M. (2016). Circulating microRNAs Predict the Initiation of NHL in a Novel In Vivo Model: Impact of Age and Sex Via a Systems Biology Approach. In BLOOD, 128(22).American Society of Hematology. doi: 10.1182/blood.V128.22.4114.4114.
Dashnamoorthy, R., Beheshti, A., Sarkar, S., Sabhachandani, P., Passero, F.C.J., Purvey, S., Boissel, L., Konry, T., & Evens, A.M. (2016). CD19 Target Activated Natural Killer (CD19.TaNK) Cellular Therapy: A Novel immunotherapeutic Approach to the Treatment of Non-Hodgkin Lymphoma (NHL). In BLOOD, 128(22).American Society of Hematology. doi: 10.1182/blood.V128.22.4174.4174.
Passero, F.C.J., Beheshti, A., Dashnamoorthy, R., & Evens, A.M. (2016). PROTEASOME INHIBITOR THERAPY IN HODGKIN LYMPHOMA: LEVERAGING SYSTEMS BIOLOGY ANALYSES FOR CELL-SPECIFIC TRANSCRIPTOME ALTERATIONS AND OPTIMUM COMBINATORIAL THERAPY. In HAEMATOLOGICA, 101, (p. 8).
Passero, F.C.J., Dashnamoorthy, R., Beheshti, A., McDonald, J.T., & Evens, A.M. (2016). Proteasome and HDAC Inhibitor Therapy in T-Cell Lymphoma (TCL) and Hodgkin Lymphoma (HL): Nuclear Factor Erythroid 2 like 2 (NRF2)-Dependent Cell Death and Function. In BLOOD, 128(22).American Society of Hematology. doi: 10.1182/blood.V128.22.3020.3020.
Beheshti, A., Neuberg, D.S., McDonald, J.T., & Evens, A.M. (2015). The Impact of Age and Sex in DLBCL: Determination of Biologic Dynamics and Delineation of Inter-Connected Signaling Networks Via a Systems Biology Analysis. In BLOOD, 126(23).
Coyle, M.E., Dashnamoorthy, R., Beheshti, A., & Evens, A.M. (2015). The PI3 Kinase (PI3K) Inhibitor, Buparlisib/BKM120, in B-Cell, T-Cell and Hodgkin Lymphoma Cell Lines: Cell Death Studies and Examination of Genomic Pathway Analyses Via a Systems Biology Approach. In BLOOD, 126(23).
Dashnamoorthy, R., Beheshti, A., Abermil, N., Lansigan, F., Kinlaw, W., Gartenhaus, R., Jones, G., Hlatky, L., & Evens, A.M. (2015). Lipid Addiction of Diffuse Large B-Cell Lymphoma (DLBCL): Fatty Acid Synthase (FASN) and PI3K Dependent Cell Death Identifies a Novel Therapeutic Paradigm. In BLOOD, 126(23).
Kritharis, A., McDonald, J.T., Beheshti, A., Pilichowska, M., Burgess, K., Ricks-Santi, L., McNiel, E., Dashnamoorthy, R., & Evens, A.M. (2015). A Comparative Oncology Analysis of Canine T-Cell Lymphoma (TCL): Immunohistochemical Study and Next Generation Sequencing for Protein Analysis and Genomic Target Discovery. In BLOOD, 126(23).
Passero, F.C.J., Dashnamoorthy, R., Beheshti, A., Hlatky, L., Abermil, N., Coyle, M.E., Sharma, J., & Evens, A.M. (2015). The Proteasome Inhibitor, Ixazomib, Combined with Novel Drug Combinations in T-Cell Lymphoma (TCL) and Hodgkin Lymphoma (HL): Identification of Key Genes and Signaling Pathways Via a Novel Systems Biology Approach. In BLOOD, 126(23).
Dashnamoorthy, R., Abermil, N., Behesti, A., Kozlowski, P., Lansigan, F., Kinlaw, W.B., Gartenhaus, R., Jones, G., Hlatky, L., & Evens, A.M. (2014). The Lipid Addiction of Diffuse Large B-Cell Lymphoma (DLBCL) and Potential Treatment Strategies with Novel Fatty Acid Synthase (FASN) Small Molecule Inhibitors. In BLOOD, 124(21).
Dashnamoorthy, R., Behesti, A., Abermil, N., Sharma, J., Coyle, M., Kandela, I., Mazar, A., Hlatky, L., & Evens, A.M. (2014). Genome-Wide Analysis Reveals MYC-Dependent Cell Death and Identifies Predictive Biomarkers of Ixazomib Sensitivity in Preclinical Models of T-Cell Lymphoma (TCL) and Hodgkin Lymphoma (HL). In BLOOD, 124(21).
Kritharis, A., Fowler, T., Dashnamoorthy, R., Burgess, K.E., Beheshti, A., Abermil, N., Roy, A., Hlatky, L., Pilichowska, M., McNiel, E., & Evens, A.M. (2014). A Comparative Oncology Study of Canine and Human Genomics and Proteomics in Peripheral T-Cell Lymphoma (PTCL): Examination of Shared Oncogenic Signaling for Biomarker and Therapeutic Target Discovery. In BLOOD, 124(21).
Almog, N., Ma, L., Christine, B., Rietman, E., Beheshti, A., & Abdollahi, A. (2013). microRNAs: Master regulators of human tumor dormancy. In CANCER RESEARCH, 73(3_Supplement).American Association for Cancer Research (AACR). doi: 10.1158/1538-7445.TIM2013-PR13.

Afshin Beheshti

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