Pitt | Swanson Engineering



  • Asiyeh Golabchi, Bingchen Wu, Xia Lia, Diane L. Carlisle, Takashi D. Y. Kozai, Robert M. Friedlander, Xinyan Tracy Cui, Melatonin improves quality and longevity of chronic neural recording, Biomaterials [Link][Free Link till Sept 20th]

  • Akhil Patel, Yingfei Xue, Rebecca Hartley, Vinayak Sant, James Eles, Xinyan Tracy Cui, Donna Beer Stolz, Shilpa Sant, Hierarchically aligned fibrous hydrogel films through microfluidic self‐assembly of graphene and polysaccharides, Bioengineering and Biotechnology, First published: 16 July 2018 [Link]

  • James Eles, Alberto Vazquez, TK Kozai, X. Tracy Cui, In vivo imaging of neuronal calcium during electrode implantation: spatial and temporal mapping of damage and recovery, Biomaterials, 2018, 174: 79-94. [Link]

  • Yang Shen; Bin Cao; Noah Snyder; Kevin M. Woeppel; James Eles; Xinyan Cui, ROS Responsive Resveratrol Delivery from LDLR Peptide Conjugated PLA-coated Mesoporous Silica Nanoparticles Across the Blood-Brain Barrier, Journal of Nanobiotechnology, 2018, 16:13, [Link]

  • James Eles, Alberto Vazquez, TK Kozai, X. Tracy Cui, In vivo imaging of neuronal calcium during electrode implantation: spatial and temporal mapping of damage and recovery, Accepted by Biomaterials.

  • Kevin M. Woeppel, Xin Zheng, X. Tracy Cui, Enhancing Surface Immobilization of Bioactive Molecule via Silica Nanoparticle Base Coating, Journal of Materials Chemistry B, 2018, 10.1039/C8TB00408K [Link]

  • Cody PA, Eles JR, Lagenaur CF, Kozai TDY, Cui XT. Unique electrophysiological and impedance signatures between encapsulation types: An analysis of biological Utah array failure and benefit of a biomimetic coating in a rat model. Biomaterials. April 2018, Pages 117-128 (Link)

  • Zhanhong Jeff Du, Guo‐Qiang Bi, Xinyan Tracy Cui. Electrically Controlled Neurochemical Release from Dual-Layer Conducting Polymer Films for Precise Modulation of Neural Network Activity in Rat Barrel Cortex, Advanced functional Materials, DOI: 10.1002/adfm.201703988

  • Michelson NJ, Vazquez AL, Eles JR, Salatino JW, Purcell EK, Williams JJ, Cui XT, Kozai TDY. Multi-scale, multi-modal analysis uncovers complex relationship at the brain tissue-implant neural interface: New Emphasis on the Biological Interface. J Neural Engineering. 2017 Nov 28. doi: 10.1088/1741-2552/aa9dae, [Link


  • Woeppel K, Yang Q, Cui XT, Recent Advances in Neural Electrode-Tissue Interface, Current Opinion in Biomedical Engineering, December 2017,Vol 4,  Pages 21-31 [Link]

  • Catt K, Li H, Hoang V, Beard R, Cui XT, Self-Powered Therapeutic Release from Conducting Polymer/Graphene Oxide Films on Magnesium, Nanomedicine: Nanotechnology, Biology and Medicine, In Press, Corrected Proof. [Link]

  • Taylor IM, Du Z, Bigelow E, Eles JR, Horner AR, Catt K, Webser S, Jamieson B, Cui XT. Aptamer-functionalized neural recording electrodes for the direct measurement of cocaine in vivo. Journal of Materials Chemistry B. 2017, Accepted manuscript. [Link]

  • Du Z, Kolarcik CL, Kozai TDY, Luebben SD, Sapp SA, Zheng XS, Nabity JA, Cui XT. Ultrasoft microwire neural electrodes improve chronic tissue integration. Acta Biomaterialia. 2017, in press. [Link]

  • Eles JR, Vazquez AL, Snyder NR, Lagenaur C, Murphy MC, Kozai TDY, Cui XT. Neuroadhesive L1 coating attenuates acute microglial attachment to neural electrodes as revealed by live two-photon microscopy. Biomaterials. 2017, 113: 279-92. [Link]


  • Khilwani, Gilgunn PJ, Kozai TDY, Ong XC, Korkmaz E, Gunalan PK, Cui XT, Fedder GK, Ozdoganlar OB, Ultra-miniature ultra-compliant neural probes with dissolvable delivery needles: design, fabrication and characterization. Biomedical microdevices, 2016. 18(6): p. 97 [Link]

  • Catt K, Li H, Cui XT. Poly(3, 4-ethylenedioxythiophene) graphene oxide composite coatings for controlling magnesium implant corrosion. Acta Biomaterialia. 2016, 48(15): 530-540 [Link]

  • Degenhart AD*, Eles JR*, Dum R, Mischel JL, Smalianchuk I, Endler B, Ashmore RC, Tyler-Kabara EC, Hatsopoulos NG, Wang W, Batista AP, Cui XT. Histological evaluation of a chronically-implanted electrocorticographic electrode grid in a non-human primate. Journal of Neural Engineering. 2016, 13(4): 046019 [Link] [*Authors contributed equally]

  • Taylor IM, Robbins EM, Catt KA, Cody PA, Happe CL, Cui XT. Enhanced dopamine detection sensitivity by PEDOT/graphene oxide coating on in vivo carbon fiber electrodes. Biosensors and Bioelectronics. 2016 [In press] [Link]

  • Kozai TDY, Jaquins-Gerst AS, Vazquez AL, Michael AC, Cui XT. Dexamethasone retrodialysis attenuates microglial response to implanted probes in vivoBiomaterials. 2016, 87 157-169. [Link]


  • Kozai TDY, Eles JR, Vazquez AL, Cui XT. Two-photon imaging of chronically implanted neural electrodes: Sealant Methods and new insights. Journal of Neuroscience Methods. 2015, 258(30) 46-55. [Link]

  • Alba NA, Du Z, Catt K, Kozai TDY, Cui XT. In vivo electrochemical analysis of a PEDOT/MWCNT neural electrode. Biosensors. 2015, 5(4) 618-646.

  • Kozai TDY, Catt K, Du Z, Na K, Srivannavit O, Haque RM, Seymour J, Wise KD, Yoon E, Cui XT. Chronic in vivo evaluation of PEDOT/CNT for stable neural recordings. IEEE TBME. 2015. [in press] [ Link]

  • Patel PR, Na K, Zhang H, Kozai TDY, Kotov NA, Yoon E, Chestek CA. Insertion and development of linear 8.6μm diameter channel carbon fiber electrode arrays for single unit recordings. J Neural Eng. 2015. 12 (4), 046009. [ Link]

  • Kolarcik CL, Luebben SD, Sapp SA, Hanner J, Snyder N, Kozai TDY, Chang E, Nabity JA, Nabity ST, Lagenaur CF, Cui XT. Elastomeric and soft conducting microwires for implantable neural interfaces. Soft Matter. 2015. 11. 4847-4861. [ Link]

  • Weaver C, Cui XT. Directed Neural Stem Cell Differentiation with a Functionalized Graphene Oxide Nanocomposite. Advanced Healthcare Materials. 2015. [in press] [ Link]

  • Du ZJ, Luo X, Weaver C, Cui XT. Poly (3, 4-ethylenedioxythiophene)-ionic liquid coating improves neural recording and stimulation functionality of MEAs. Journal of Material Chemistry C. 2015. [in press] [ Link]

  • Kozai TDY, Vazquez AL. Photoelectric artefact from optogenetics and imaging on microelectrodes and bioelectronics: New Challenges and Opportunities. Journal of Material Chemistry B. 2015. 3. 4965-4978. [ Link] [ cover].

  • Kozai TDY, Jaquins-Gerstl A, Vazquez AL, Michael AC, Cui XT. Brain Tissue Responses to Neural Implants Impact Signal Sensitivity and Intervention Strategies. ACS Chem. Neurosci.2015. 6(1). 48-67. [ Link] [ cover]

  • Kozai TDY, Du Z, Gugel ZV, Smith MA, Chase SM, Bodily LM, Caparosa EM, Friedlander RM, Cui XT. Comprehensive Chronic Laminar Single-Unit, Multi-Unit, and Local Field Potential Recording Performance with Planar Single Shank Electrode Arrays. J Neurosci Methods.2015. 242. 15-40. [ Link]

  • Kozai TDY, Catt K, Li X, Gugel ZV, Olafsson VT, Vazquez AL, Cui XT. Mechanical failure modes of chronically implanted planar silicon-based neural probes for laminar recording. Biomaterials. 2015. 37. 25-39.   [ Link]
  • Kolarcik CL, Catt K, Rost E, Albrecht I, Bourbeau D, Du Z, Kozai TDY, Luo X, Weber DJ, Cui XT. Evaluation of poly(3,4-ethylenedioxythiophene)/carbon nanotube neural electrode coatings for stimulation in the dorsal root ganglion. J Neural Eng.2015. 12. 016008. [ Link]


  • Kozai TDY, Li X, Bodily  LM, Caparosa EM, Zenonos GA, Carlisle DL, Friedlander RM, Cui XT. Effect of caspase-1 knockout on chronic neural recording quality and longevity: Insight into cellular and molecular mechanisms of the reactive tissue response. Biomaterials. 2014. 35(36). 9620-9634. [ Link]
  • Kozai TDY, Gugel ZV, Li X, Gilgunn PJ, Khilwani R, Ozdoganlar OB, Fedder GK, Weeber DJ, Cui XT. Chronic tissue response to carboxymethyl cellulose based dissolvable insertion needle for ultra-compliant, ultra-small neural probes. Biomaterials. 2014. 35(34). 9255-68 [ Link]
  • Freedman MS, Cui XT. Substrate Electrode Morphology Affects Electrically Controlled Drug Release from Electrodeposited Polypyrrole Films . Physical Chemistry Communications. 2014. 1(1). 15-25 [ Link]
  • Weaver CL, Li H, Luo X, Cui XT. A graphene oxide/conducting polymer nanocomposite for electrochemical dopamine detection: origin of improved sensitivity and specificity. J Mater Chem B. 2(32): 5209-5219. [ Link].
  • Wang W, Xu G, Cui XT, Sheng G, Luo X. Enhanced catalytic and dopamine sensing properties of electrochemically reduced conducting polymer nanocomposite doped with pure graphene oxide. Biosensors and Bioelectronics. 2014 Aug 15; 58: 153-6. [ Link]

  • Kozai TDY, Alba NA, Zhang H, Kotov NA, Gaunt RA, Cui XT. "Nanostructured coatings for improved charge delivery to neurons" in "Nanotechnology and Neuroscience: nano-electronic, photonic, and mechanical neuronal interfacing" Springer. 2014. [ Link]

  • Weaver CL, LaRosa JM, Luo X, and Cui XT. Electrically Controlled Drug Delivery from Graphene Oxide Nanocomposite Films. ACS Nano. 2014 8(2): 1834-1843. [ Link].


  • Zhang L, Zhang F, Weng Z, Brown BN, Yan H, Ma XM, Vosler PS, Badylak SF, Dixon CE, Cui XT, Chen J. Effect of an inductive hydrogel composed of urinary bladder matrix upon functional recovery following traumatic brain injury. Tissue Eng Part A. 2013 Sept;19(17-18):1909-18. [ Link].
  • Wang JY1, Liou AK, Ren ZH, Zhang L, Brown BN, Cui XT, Badylak SF, Cai YN, Guan YQ, Leak RK, Chen J, Ji X, Chen L. Neurorestorative effect of urinary bladder matrix-mediated neural stem cell transplantation following traumatic brain injury in rats. CNS Neurol Disord Drug Targets. 2013 May 1;12(3): 412-25. [ Link]
  • Huang J, Lee I, Luo X, Cui XT, Yun M. Shadow masking for nanomaterial-based biosensors incorporated with a microfluidic device. Biomed Microdevices. 2013 Jun;15(3):531-7. [ Link].


  • Kozai TDY, Vazquez AL, Weaver CL, Kim SG, Cui XT. In vivo two photon microscopy reveals microglial reaction to implantation of microelectrode through extension of processes. J Neural Eng.2012. 9. 066001.[ Link
  • Kolarcik, C.L., Bourbeau, D., Azemi, E., Rost, E., Zhang, L., Lagenaur, C.F., Weber, D.J. and Cui, X.T. In vivo effects of L1 coating on inflammation and neuronal health at the electrode/tissue interface in rat dorsal root ganglion and spinal cord. Acta Biomaterialia,2012. 8(10): p. 3561-75. [ Link]
  • Innam Lee, Xiliang Luo, Jiyong Huang, Xinyan Tracy Cui and Minhee Yun, Detection of Cardiac Biomarkers Using Single Polyaniline Nanowire-Based Conductometric Biosensors.Biosensors2012, 2(2), 205-220. [ Link]


  • Luo, X., C. L. Weaver, D. D. Zhou, R. Greenberg, and X. T. Cui, Highly stable carbon nanotube doped poly(3,4-ethylenedioxythiophene) for chronic neural stimulation. Biomaterials, 2011. 32(24): p. 5551-5557.Link]
  • Huang, J., X. Luo, I. Lee, Y. Hu, X. T. Cui and M. Yun, Rapid real-time electrical detection of proteins using single conducting polymer nanowire-based microfluidic aptasensor. Biosens Bioelectron, 2011. 30(1): p. 306-309.Link]
  • Luo, X., C. Matranga, S. Tan, N. Alba, and X. T. Cui, Carbon nanotube nanoreservior for controlled release of anti-inflammatory dexamethasone. Biomaterials, 2011. 32(26): p. 6316-6323.Link]
  • Stauffer, W. R., P. M. Lau, G. Q. Bi, and X. T. Cui, Rapid modulation of local neural activity by controlled drug release from polymer-coated recording microelectrodes. J Neural Eng, 2011. 8(4): 044001. [ Link]
  • Luo, X., I. Lee, J. Huang, M. Yun, and X. T. Cui, Ultrasensitive protein detection using an aptamer-functionalized single polyaniline nanowire. Chem Commun (Camb), 2011. 47(22): p. 6368-6370. [ Link]
  • Justin, G. A., Y. Zhang, X. T. Cui, C. W. Bradberry, M. Sun, and R. J. Sclabassi, A metabolic biofuel cell: conversion of human leukocyte metabolic activity to electrical currents.J Biol Eng, 2011. 5: p. 5. [ Link]
  • Lee, I., X. Luo, X. T. Cui, and M. Yun, Highly sensitive single polyaniline nanowire biosensor for the detection of immunoglobulin G and myoglobin. Biosens Bioelectron, 2011. 26(7): p. 3297-3302. [ Link]
  • Collinger, J. L., B. E. Dicianno, D. J. Weber, X. T. Cui, W. Wang, D. M. Brienza, and M. L. Boninger Integrating rehabilitation engineering technology with biologics. PM R, 2011. 3(6 Suppl 1): p. S148-157. [ Link]
  • Luo, X. and X. T. Cui, Electrochemical deposition of conducting polymer coatings on magnesium surfaces in ionic liquid. Acta Biomater, 2011. 7(1): p. 441-446. [ Link]
  • Azemi, E., C. F. Lagenaur, and X. T. Cui, The surface immobilization of the neural adhesion molecule L1 on neural probes and its effect on neuronal density and gliosis at the probe/tissue interface. Biomaterials, 2011. 32(3): p.681-692. [ Link]


  • Ling Zhang, William R. Stauffer, Esther P. Jane, Paul J. Sammak and Xinyan Tracy Cui, Enhanced Differentiation of Embryonic and Neural Stem Cells to Neuronal Fates on Laminin Peptides Doped Polypyrrole, Macromol Biosci, 2010. 10(12): p. 1456-1464. [ Link]
  • Nicolsa Alba, Mingui Sun, Robert Scalbassi, Xinyan Tracy Cui, Novel Hydrogel-Based Preparation- Free EEG Electrode. IEEE Trans Neural Syst Rehabil Eng, 2010, 18(4): p. 415-423. [ Link]
  • Erdrin Azemi, Glenn Gobbel, Xinyan Tracy Cui, Seeding Neural Progenitor Cells on Silicon Based Neural Probes. J Neurosurg, 2010, 113(3): p. 673-681.Link]


  • Xiliang Luo and Xinyan Tracy Cui, Sponge-like nanostructured conducting polymers for electrically controlled drug release. Electrochemistry Communications, 2009. 11(10), p. 1956-1959. [ Link]
  • Luo, X. and X.T. Cui, Electrochemically controlled release based on nanoporous conducting polymers. Electrochemistry Communications, 2009. 11(2): p. 402-404. [ Link]


  • Wei Liao, Nicolas J. Alba, Brad Randall and X. Tracy Cui, Conducting Polymer-based Impedimetric Aptamer Biosensor for in situ Detection. Analytical and Bioanalytical Chemistry, 2008. 392(5): p. 861-864. [ Link]
  • Azemi, E., Stauffer, W. R., Gostock, M. S., Lagenaur, C. F., Cui, X. T., Surface immobilization of neural adhesion molecule L1 for improving the biocompatibility of chronic neural probes: In vitro characterization. Acta Biomater, 2008. 4: p. 1208-1217. [ Link]
  • Brayfield, C. A., Marra, K. G., Leonard, J. P.,Tracy Cui, X.,Gerlach, J. C. Excimer laser channel creation in polyethersulfone hollow fibers for compartmentalized in vitro neuronal cell culture scaffolds. Acta Biomater, 2008. 4(2): p. 244-255.  [ Link]


  • Cui XT, Zhou DD, Poly (3,4-ethylenedioxythiophene) for Chronic Neural Stimulation. IEEE Transactions on Neural Systems & Rehabilitation Engineering, 2007. 15: p. 502-508. [ Link]
  • Liao W, Cui XT: Reagentless aptamer based impedance biosensor for monitoring a neuroinflammatory cytokine PDGF. Biosensors and Bioelectronics, 2007. 23: 218-224. [ Link]
  • Widge AS, Jeffries-El M, Cui X, Lagenaur CF, Matsuoka Y, Self-assembled monolayers of polythiophene conductive polymers improve biocompatibility and electrical impedance of neural electrodes. Biosens Bioelectron. 2007. 22(8):, p. 1723-1732. [ Link]


  • Schwartz AB, Cui XT, Weber DJ, Moran DW, Brain-controlled interfaces: movement restoration with neural prosthetics. Neuron, 2006. 52(1): p. 205-220. [ Link]
  • Yinghong Xiao; David C. Martin; Xinyan Cui and Mehash Shenai, Surface modification of neural probes with conducting polymer poly(hydroxymethylated-3,4-ethylenedioxythiophene) and its biocompatibility. Applied Biochemistry and Biotechnology, 2006. 128(2): 117-130. [Link]
  • William R. Stauffer and Xinyan T. Cui, Polypyrrole doped with 2 peptide sequences from laminin. Biomaterials, 2006. 27(11): p. 2405-2413. [ Link]
  • Reecha Wadhwa, Carl F. Lagenaur and Xinyan Tracy Cui, Electrochemically controlled release of dexamethasone from conducting polymer polypyrrole coated electrode. Journal of Controlled Release, 2006.110(3): p. 531-541. [ Link]