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THREADRITE IV: NOVEL WAY TO QUICKLY AND ACCURATELY PLACE IV CATHETERS
Peripheral vascular access drug delivery is a mainstay of modern healthcare. Virtually all ER and hospital patients get peripheral IV lines, yet under half of attempted placements are successful. With 1.2 billion pIVs purchased in N. America last year, there is significant risks of extravascular...
NOVEL VENTRICULOAMNIOTIC SHUNT FOR FETAL AQUEDUCTAL STENOSIS
Severe fetal central nervous system (CNS) hydrocephalus occurs 3-5 cases per 10,000 deliveries. Aqueductal Stenosis (AS) is a developmental anomaly that causes hydrocephalus by obstructing the brain’s ventricular system. Older style shunts are still placed in fetuses with lesions other than AS, and...
I-HITS: INDIVIDUALIZED HAND IMPROVEMENT AND TRACKING SYSTEM AFTER STROKE
Stroke, or the sudden interruption of blood supply of the brain, is the leading cause of disability in the United States. Eighty five percent of the 795,000 individuals who sustain a stroke annually in the United States have difficulty moving one arm or hand, significantly affecting their long-term...
MINIMALLY INVASIVE DELIVERY OF THERAPEUTIC CELLS TO ABDOMINAL AORTIC ANEURYSM
7-10% of US males are affected by abdominal aortic aneurysm, a focal balloon-like dilatation of the distal aorta. A rupture is life-threatening, being 13th leading cause of death in the US. Large aneurysms can be treated with surgery, but there is no existing treatment for small aneurysms, which...
HEMOGLOBIN REPLACEMENT DEVICE TREATMENT OF SICKLE CELL DISEASE
Sickle Cell Disease, also known as hemoglobinopathy, is a genetic defect resulting in abnormal structure of the hemoglobin molecules. Abnormally shaped RBCs cause gradual, eventually fatal damage to all organs. Transfusion of normal RBCs prolongs life, but repeated transfusion leads to...
MOTORIZED, FLEXIBLE ARM RETRACTOR FOR OPEN ABDOMINAL SURGERY
Open abdominal surgery presents several challenges: anatomic complexity, depth of the cavity, fragility of the different organs present, and technical issues exacerbated by morbid obesity. Current retractor technology is bulky, obtrusive, inefficient, and hasn’t notably progressed in 30 years. The...
INTRAPANCREATIC LIPID NANOPARTICLES TO TREAT DIABETES
Diabetes mellitus has become a massive worldwide problem. In the US, it is the number one biomedical financial burden. Recent analyses reveal that nearly 30 million Americans suffer from diabetes mellitus. The grant will be used for the development of a nanoparticle technology for the treatment of...
THE ESOPHOCCLUDE: TEMPORARY ESOPHAGUS OCCLUSION FOR EMERGENT INTUBATION
Gastric aspiration is a devastating complication of intubation and other clinical scenarios. An estimated 3.5% of intubations result in aspiration. 8-10% of affected patients die, and others experience repeated lung infections. Worse, it is underreported and misdiagnosed. The Esophocclude is a...
REGENMATRIX: COLLAGEN-MIMETIC BIOACTIVE HYDROGELS FOR BONE REGENERATION
20% of high-impact bone fractures result in delayed healing or non-union, but there is no effective treatment for induction of bone regeneration. RegenMatrix is a bioactive hydrogel, designed to mimic the bone regenerative microenvironment, which would improve on the limited bone regrowth outcomes...
OBJECTIVE POSTPARTUM UTERINE TONE MONITORING
Death from postpartum hemorrhage is one of the most common preventable causes of maternal death in the United States, and is the single leading cause of maternal mortality worldwide. There is currently no objective measurement of uterine contraction, which is most responsible for postpartum...
A NOVEL THERMAL BLOCK TECHNOLOGY TO BLOCK NERVE CONDUCTION
Many chronic disorders like obesity, chronic pain, heart failure and bladder voiding dysfunction are caused by neuronal overactivity in the peripheral or central nervous system. Currently, there is no safe and reliable method to suppress or block peripheral nerve activity that can be used for these...
OrganEvac/Whole Organ Thrombolysis Device
Currently there are around 14,000 individuals listed on the liver transplant wait list, with only 7000 getting transplants and 2200 of them die waiting for livers. The early stage seed grant will demonstrate proof of concept of a new technology to lyse thrombus in human liver tissue. The technology...