Pitt | Swanson Engineering
Little, Steven R.
Engr-Dept Chairperson's Office, Chem/Petroleum Engineering, Bioengineering Department
Little, Steven R.
William Kepler Whiteford Professor and Department Chair
Faculty
Professor
Office: 940 Benedum Hall
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PhD in Chemical Engineering, Massachusetts Institute of Technology, 2005

BS in Chemical Engineering, Youngstown State University, 2000

Biomaterials

Controlled release

Delivery of drugs to the eye

Drug delivery systems

Immunotherapies

Regenerative Medicine

(2015) Curtis W. McGraw Research Award - American Society for Engineering Education.

(2015) Named "Fellow of the University Honors College", University of Pittsburgh.

(2015) The Carnegie Science Award in the Category of Advanced Materials.

(2014) Institute for Clinical Research Distinguished Alumni Award.

(2014) Named One of Five Pittsburgh "Disruptors" Who are "Shaking Up the Status Quo and Reshaping Our World" by Pop City Pittsburgh.

(2014) Phase II Coulter Translational Research Award.

(2014) Research to Prevent Blindness - Innovative Ophthalmic Research Award.

(2014) Selected as one of Pittsburgh Magazine's "40 under 40".

(2013) Carnegie Science Award in the Category of University Educator.

(2013) Chancellors Distinguished Teaching Award.

(2012) Best Diversity Mentor Award.

(2012) Camille Dreyfus Teacher-Scholar.

(2012) Chancellor's Distinguished Research Award.

(2012) Invited Participant, NAE's Frontiers of Engineering Symposium.

(2012) Pitt Innovator Award.

(2012) Society for Biomaterials Young Investigator Award.

(2010) Most Outstanding Young Alumni.

(2010) Phase I Coulter Translational Research Award.

(2009) Board of Visitor's Award - Most Outstanding Faculty Member in the School of Engineering.

(2009) Distinguished Faculty Fellowship.

(2008) Beckman Foundation Young Investigator Award.

(2008) ICRE Award.

(2007) AHA Career Development Award.

(2007) Distinguished Faculty Fellowship.

(2007) NIH K-Award.

(2005) AAAS Excellence in Research Award.

(2000) National Science Foundation Graduate Fellow.

(2000) Phi Kappa Phi Mavrigian-Grim Graduate Fellow.

(2000) Tau Beta Pi Graduate Fellow.

(1999) ACS Organic Chemistry Award.

(1999) AIChE Professional Promise Award.

(1999) Eugene D. Scudder Physical Chemistry Award.

Acharya, A.P., and Little, S.R., "Stapled Endosome Disrupting Alginate Particles for Cytosolic Delivery of Cations," Journal of Drug Targeting, Manuscript submitted for publication.

Balmert, S.C., Carey, C.D., Vu, J.R., Fedorchak, M.V., Falo, L.D., and Little, S.R., "In Vivo Expansion of Regulatory T Cells by Sustained Release of Treg Inducing Factors Suppresses Inflammation in a Model of Allergic Contact Dermatitis," Journal of Investigative Dermatology, Manuscript submitted for publication.

Balmert, S.C., Zmolek, A.C., Glowacki, A.J., Knab, T.D., Rothstein, S.N., Wokpetah, J., Maskarinec, D., Fedorchak, M.V., Parker, R.S., and Little, S.R., "Controlled Release of "Sticky" Peptides and Proteins: Effects of Charge on Release Kinetics from Poly(Lactic-co-Glycolic) Acid Microspheres," Biomaterials, Manuscript submitted for publication.

Fisher, J.D., Acharya, A.P., and Little, S., In press, "Immunomodulation for Preventing Allotransplant Rejection Using Nano and Microparticle Delivery Systems," Clinical Immunology.

Glowacki, A.J., Yoshizawa, S.A., Jhunjhunwala, S., Moncla, B.J., Garlet, G.P., Sfeir, C.S., and Little, S., "Recruitment of Regulatory Lymphocytes for the Treatment of Periodontal Disease," Nature Medicine, Manuscript submitted for publication.

Guaragno, M., Gottardi, R., Fedorchak, M.V., Roy, A., Kumta, P.N., and Little, S.R., "One-Step Synthesis of Fluorescently Labeled Single-Walled Carbon Nanotubes," Chemical Communications, Manuscript submitted for publication.

Knab, T.D., Little, S.R., and Parker, R.S., "Mathematical model of accelerated degradation and drug release from polymeric microspheres in the presence of reactive oxygen species," Journal of Controlled Release, Manuscript submitted for publication.

Ko, H.F., Little, S., Sfeir, C., and Kumta, P.N., "High Throughput Optimization of Fibrin/Gelatin Based 3-D Non-viral Gene Delivery Systems Containing Nanostructured Calcium Phosphates," To appear in Advanced Functional Materials.

Lash, M.H., Belvins, L., Jordan, J., Fedorchak, M.V., Little, S.R., and McCarthy, J.J., In press, "Non-Brownian Particle-based Materials with Micro-and Nano-scale Hierarchy," Angewandte Chemie.

Lash, M.H., Fedorchak, M.V., McCarthy, J.J., and Little, S.R., "Scaling Up Self-Assembly: Bottom-Up Approaches to Macroscopic Particle Organization," Soft Matter, Manuscript submitted for publication.

Roy, A., Jhunjhunwala, S., Bayer, E., Fedorchak, M.V., Little, S.R., and Kumta, P., "Calcium Phosphate-Poly(Lactic-co-Glycolic) Acid Microsphere Composite Porous Bone Cements with Tunable Controlled Release," Advanced Healthcare Materials, Manuscript submitted for publication.

Vilches, C.S., Ramirez, V.T., Gleisner, A., Ureta, G., Sauma, D., Morales, J., Jhunjhunwala, S., Little, S., Rosemblatt, M., Bono, M., and Fierro, J.A., "Down-regulation of allo-antibodies and alloreactive T cells by synthetic allogeneic PLGA-phagosomes," Manuscript submitted for publication.

Washington, M.A., Fedorchak, M., Rothstein, S.N., Little, S.R., and Meyer, T.Y., "Mapping the Acidic Microclimate within Sequenced and Random PLGA Microparticles using Two-Photon Microscopy," Proceedings of the National Academy of Science, Manuscript submitted for publication.

Glowacki, A.J., Gottardi, R., Yoshizawa, S., Cavalla, F., Garlet, G.P., Sfeir, C., and Little, S., 2015, "Strategies to direct the enrichment, expansion, and recruitment of regulatory cells for the treatment of disease," Annals of Biomedical Engineering, 25245220.

Fedorchak, M.V., Wingard, J., Medina, C., Albeiruti, E., Schuman, J., and Little, S., 2014, "28-day Ocular Delivery of Brimonidine Tartrate From Rationally Designed Degradable Microparticles in a Rabbit Model," Journal of Controlled Release, vol.125, pp. 210-16, 24983144.

Fu, H., Hong, Y., Little, S., and Wagner, W.R., 2014, "Collagenase-Labile polyurethane urea synthesis and processing into hollow fiber membranes," Biomacromolecules, vol.15, no.8, pp. 2924-2932, 25003560.

Garket, G.P., Sfeir, C.S., and Little, S., 2014, "Restoring host-microbe homeostasis via selective chemoattraction of Tregs," Journal of Dental Research, vol.93, no.9, pp. 834-839, 25056995.

Glowacki, A.J., Yoshizawa, S., Jhunjhunwala, S., Vieira, A.E., Garlet, G.P., Sfeir, C., and Little, S., 2014, "Prevention of Inflammation-Mediated Bone Loss in Murine and Caine Periodontal Disease via Recruitment of Regulatory Lymphocytes," Proceedings of the National Academy of Science, vol.110, no.46, pp. 18525-30, 24167272.

Lash, M.H., Fedorchak, M., Little, S., and Mccarthy, J.J., 2014, "Fabrication and characterization of non-Brownian particle-based crystals," Langmuir, no.2, 24983125.

Mealy, J.E., Fedorchak, M., and Little, S.R., 2014, "In Vivo Characterization of a Controlled Release Ocular Insert for the Delivery of Brimonidine Tartrate," Acta Biomateriala, vol.10, no.1, pp. 87-93, 24080317.

Rothstein, S.N., Donahue, C., Falo, L.D., and Little, S., 2014, "In silico programming of degradable microparticles to hide and then reveal immunogenic payloads in vivo," Journal of Materials Chemistry B, vol.2, no.37, pp. 6183-6187.

Rothstein, S.N., Huber, K.D., Sluis-Cremer, N., and Little, S.R., 2014, "In Vitro Characterization of a Sustained Release Formulation of Enfuvirtide," Antimicrobial Agents and Chemotherapy, vol.58, no.3, pp. 1797-8, 24366751.

Fedorchak, M., Cugini, A., Schuman, J.S., and Little, S., 2013, "The Monthly Eye Drop: Development of a Long-Term, Noninvasive Glaucoma Treatment System," Investigative Ophthalmology & Visual Science, vol.54, p. 4294.

Kamalasanan, K., Gottardi, R., Tan, S., Chen, Y., Gonduru, B., Rothenstein, S.N., Star, A., and Little, S., 2013, "Zero Dimensional Single Walled Carbon Nanotubes," Angewandte Chemie International Edition, vol.52, no.43, pp. 11308-12, 24038731.

Little, S., 2012, "Re-orienting our View of Particle-Based Adjuvants for Subunit Vaccines," Proceedings of the National Academy of Science, vol.109, no.4, pp. 999-1000, 22308523.

Balmert, S.C., and Little, S., 2012, "Biomimetic Delivery with Micro and Nanoparticles," Advanced Materials, vol.24, no.28, pp. 3757-78, 22528985.

Balmert, S.C., and Little, S., 2012, "Biomimetic, Anisotropic Drug Delivery Systems," in Handbook of Biomimetics and Bioinspiration: Volume I, World Scientific Publishing, Singapore.

Eghtesad, S., Jhunjhunwala, S., Little, S., and Clemens, P.R., 2012, "Local rapamycin treatment decreases immunity induced by vector-mediated dystrophin cDNA expression in adult mdx skeletal muscle," Scientific Reports (Nature), vol.2, no.399, 22570764.

Jhunjhunwala, S., Balmert, S.C., Raimondi, G., Dons, E., Nichols, E., Thomson, S., and Little, S., 2012, "Controlled Release Formulations of IL-2, TGF-ß1 and Rapamycin for the Induction of Regulatory T Cells," Journal of Controlled Release, vol.159, no.1, pp. 78-84, 22285546.

Jhunjhunwala, S., Raimondi, G., Glowacki, A.J., Hall, S.H., Maskarenic, D., Thorne, S.H., Thomson, A.W., and Little, S., 2012, "Bio-Inspired Controlled Release of CCL-22 Recruits Regulatory T-cells in vivo," Advanced Materials, vol.24, pp. 4735-38, 22821823.

Li, J., Rothstein, S.N., Little, S., Edenborn, H.N., and Meyer, T.Y., 2012, "The Effect of Monomer Order on the Hydrolysis of Biodegradable Poly(Lactic-co-Glycolic acid) Repeating Sequence Copolymers," Journal of the American Chemical Society, vol.134, no.39, pp. 16352-9, 22950719.

Rothstein, S.N., Kay, J., and Little, S., 2012, "A Retrospective Mathematical Analysis of Controlled Release Design and Experimentation," Molecular Pharmaceutics, vol.9, no.11, pp. 3003-11, 23009671.

Tengood, J., Maskarinec, D., Ridenour, R., and Little, S., 2012, "A Mathematical Model for Controlled Release of Biologics from Porous Hollow Fibers," Journal of Biomedical Materials Research, Part A, vol.100, no.4, pp. 817-26, 22275332.

Dutt, M., Kuksenok, O., Little, S., and Balazs, A.C., 2011, "Forming transmembrane channels using end-functionalized nanotubes," Nanoscale, vol.3, no.1, pp. 240-50, 20976358.

Dutt, M., Kuksenok, O., Nayhouse, M.J., Little, S., and Balazs, A., 2011, "Modeling the Self-assembly of Lipids and Nanotubes in Solution: Forming Vesicles and Bicelles with Trans-membrane Nanotube Channels," ACS Nano, vol.5, no.6, pp. 4769-82, 21604769.

Dutt, M., Nayhouse, M., Kuksenok, O., Little, S., and Balazs, A., 2011, "Interactions of End-functionalized Nanotubes with Lipid Vesicles: Spontaneous Insertion and Nanotube Self-organization," Current Nanoscience, vol.7, no.5, pp. 699-715.

Eghtesad, S., Jhunjhunwala, S., Little, S., and Clemens, P.R., 2011, "Rapamycin ameliorates dystrophic phenotype in mdx mouse skeletal muscle," Molecular Medicine, vol.17, no.9-10, pp. 917-24, 21607286.

Jhunjhunwala, S., and Little, S., 2011, "Microparticulate Systems for Targeted Drug Delivery to Phagocytes," Cell Cycle, vol.10, no.13, pp. 1-2, 21623160.

Kamalasanan, K., Jhunjunwala, S., Wu, J., Swanson, A., Gao, D., and Little, S., 2011, "Patchy Anisotropic Microspheres with Soft Protein Islets," Angewandte Chemie International Edition, vol.50, no.37, pp. 8706-08, 21809425.

Rothstein, S.N., and Little, S., 2011, "A "tool box" for rational design of degradable controlled release formulations," Journal of Materials Chemistry, vol.21, pp. 29-39.

Tengood, J., Ridenour, R., Brodsky, R., Russell, A., and Little, S., 2011, "Sequential Delivery of basic Fibroblast Growth Factor and Platelet Derived Growth Factor for Angiogenesis," Tissue Engineering Part A, vol.17, no.9-10, pp. 1181-89, 21142700.

Brito, L., Chandrasekhar, S., Little, S., and Amiji, M., 2010, "Non-Viral eNOS Gene Delivery and Transfection with Stents for the Treatment of Coronary Restenosis," BioMedical Engineering OnLine, 20875110.

Brito, L.A., Chandrasekhar, S., Little, S., and Amiji, M.M., 2010, "In Vitro and In Vivo Studies of Local Arterial Gene Delivery and Transfection using Lipopolyplexes-Embedded Stents," Journal of Biomedical Materials Research Part A, vol.93, no.1, pp. 325-36, 19569206.

Fierro, J.A., Ramirez, V., Silva, C., Ruiz, P., Gleisner, A., Morales, J., Jhunjhunwala, S., Little, S., Bono, M.R., and Rosemblatt, M., 2010, "Transference of Phagosomes in an Allogeneic Immunisation Protocol Down Regulates the Production of Anti-MHC Antibodies and T Cell Mediated Alloreactivity," American Journal of Transplantation, vol.10, no.14, p. 562.

Tengood, J., Kovach, K.M., Vescovi, P.E., Russell, A., and Little, S., 2010, "Sequential Delivery of Vascular Endothelial Growth Factor and Sphingosine 1-Phosphate for Angiogenesis," Biomaterials, vol.30, pp. 7805-12, 20674008.

van Vlerken, L.E., Duan, Z., Little, S., Seiden, M.V., and Amiji, M.M., 2010, "Augmentation of Therapeutic Efficacy in Drug-Resistant Tumor Models Using Ceramide Coadministration in Temporal-Controlled Polymer-Blend Nanoparticle Delivery Systems," The AAPS Journal, vol.12, no.2, pp. 171-80, 20143195.

Jhunjhunwala, S., Raimondi, G., Thomson, A., and Little, S., 2009, "Delivery Of Rapamycin To Dendritic Cells Using Degradable Microparticles," Journal of Controlled Release, 19000726.

Kokai, L.E., Tan, H., Jhunjhunwala, S., Little, S., Frank, J., and Marra, K.G., 2009, "Protein Bioactivity and Polymer Orientation is Affected by Stabilizer Incorporation in Double-Walled Microspheres," Journal of Controlled Release, 19751780.

Rothstein, S.N., Federspiel, W.J., and Little, S., 2009, "A Unified Mathematical Model for the Prediction of Controlled Release from Surface and Bulk Eroding Polymer Matrices," Biomaterials, 19101031.

Yadav, S., van Vlerken, L.E., Little, S., and Amiji, M.M., 2009, "Evaluations of Combination MDR-1 Gene Silencing and Paclitaxel Administration in Biodegradable Polymeric Nanoparticle Formulations to Overcome Multidrug Resistance in Cancer Cells," Cancer Chemother Pharmacol, 18618115.

Little, S., and Kohane, D.S., 2008, "Polymers for Intracellular Delivery of Nucleic Acids," Journal of Materials Chemistry.

Brito, L., Little, S., Langer, R., and Amiji, M., 2008, "Poly (ß-Amino Ester) and Cationic Phospholipid-Based Lipopolyplexes for Gene Delivery and Transfection in Human Aortic Endothelial and Smooth Muscle Cells," Biomacromolecules, 18307309.

Raimondi, G., Jhunjhunwala, S., Thomson, A.W., and Little, S., 2008, "Targeted delivery of rapamycin to dendritic cells using biodegradable microparticles is highly effective in suppressing their maturation and function," American Journal of Transplantation, vol.8, no.423.

Rothstein, S.N., Federspiel, W.J., and Little, S., 2008, "A Simple Model Framework for the Prediction of Controlled Release from Hydrated Biodegradable Polymer Matrices," Journal of Materials Chemistry.

van Vlerken, L.E., Duan, Z., Little, S., Seiden, M.V., and Amiji, M., 2008, "Biodistribution and Pharmacokinetic Analysis of Paclitaxel and Ceramide Administered in Multifunctional Polymer-Blend Nanoparticles in Drug Resistant Breast Cancer Model," Mol Pharmaceutics, 18616278.

Devalapally, H., Shenoy, D., Little, S., Langer, R., and Amiji, M., 2007, "Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs: part 3. Therapeutic efficacy and safety studies in ovarian cancer xenograft model.," Cancer chemotherapy and pharmacology, vol.59, no.4, pp. 477-84, 16862429.

Little, S., and Langer, R., 2006, "Non-Viral Genetic Vaccines for Cancer," in Gene Therapy for Cancer, Humana Press, New Jersey.

Zugates, G.T., Anderson, D.G., Little, S., Lawhorn, E.B., and Langer, R., 2006, "Synthesis of Poly(ß-Amino Ester)s with Thiol-Reactive Side Chains for DNA Delivery," Journal of the American Chemical Society, 17002366.

Little, S.R., and Langer, R., 2005, "Nonviral delivery of cancer genetic vaccines.," Advances in biochemical engineering/biotechnology, vol.99, pp. 93-118, 16568889.

Little, S.R., Lynn, D.M., Puram, S.V., and Langer, R., 2005, "Formulation and characterization of poly (beta amino ester) microparticles for genetic vaccine delivery.," Journal of controlled release : official journal of the Controlled Release Society, vol.107, no.3, pp. 449-62, 16112767.

Pfeifer, B.A., Burdick, J.A., Little, S.R., and Langer, R., 2005, "Poly(ester-anhydride):poly(beta-amino ester) micro- and nanospheres: DNA encapsulation and cellular transfection.," International journal of pharmaceutics, vol.304, no.1-2, pp. 210-9, 16174553.

Shenoy, D., Little, S., Langer, R., and Amiji, M., 2005, "Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs: part 2. In vivo distribution and tumor localization studies.," Pharmaceutical research, vol.22, no.12, pp. 2107-14, 16254763.

Wood, K.C., Little, S.R., Langer, R., and Hammond, P.T., 2005, "A family of hierarchically self-assembling linear-dendritic hybrid polymers for highly efficient targeted gene delivery.," Angewandte Chemie (International ed. in English), vol.44, no.41, pp. 6704-8, 16173106.

Zugates, G.T., Little, S., Anderson, D.G., and Langer, R., 2005, "Poly(Beta-Amino Ester)s for DNA Delivery," Israel Journal of Chemistry, vol.45, pp. 477-85.

Little, S.R., Lynn, D.M., Ge, Q., Anderson, D.G., Puram, S.V., Chen, J., Eisen, H.N., and Langer, R., 2004, "Poly-beta amino ester-containing microparticles enhance the activity of nonviral genetic vaccines.," Proceedings of the National Academy of Sciences of the United States of America, vol.101, no.26, pp. 9534-9, 15210954.

Haining, W.N., Anderson, D.G., Little, S.R., von Bergwelt-Baildon, M.S., Cardoso, A.A., Alves, P., Kosmatopoulos, K., Nadler, L.M., Langer, R., Kohane, D.S., and von Berwelt-Baildon, M.S., 2004, "pH-triggered microparticles for peptide vaccination.," Journal of immunology (Baltimore, Md. : 1950), vol.173, no.4, pp. 2578-85, 15294974.

Araujo-Pires, A.C., Vieira, A.E., Biguetti, C.C., Glowacki, A., Yoshizawa, S., Campanello, A.P., Sfeir, C., Garlet, G.P., Little, S., and Francisconi, C.F., "IL-4/CCL22/CCR4 Axis Controls Regulatory T-Cell Migration That Suppresses Inflammatory Bone Loss in Murine Experimental Periodontitis," Journal of Bone and Mineral Research, vol.30, no.3, pp. 400-410, 25264308.

Choleris, E., Little, S., Mong, J.A., Puram, S.V., Langer, R., and Pfaff, D.W., "Functional mRNA for Oxytocin Receptor Required in the Amygdala to Support Social Recognition," Proceedings of the National Academy of Sciences, 17360582.

Jhunjhunwala, S., Raimondi, G., Nichols, E., Thomson, A.W., and Little, S., "All-trans Retinoic Acid and Rapamycin Synergize with Transforming Growth Factor-beta 1 to Induce Regulatory T Cells with Different Migratory Capacities," Journal of Leukocyte Biology, vol.95, no.5, pp. 981-9, 23898044.

Shenoy, D., Little, S., Langer, R., and Amiji, M., "Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs. 1. In vitro evaluations.," Molecular pharmaceutics, vol.2, no.5, pp. 357-66, 16196488.

Bayer, E., Fedorchak, M.V., Roy, A., Kumta, P., and Little, S.R., 2015, "Sequential Growth Factor Delivery for Bone Tissue Regeneration," McGowan Institute for Regenerative Medicine Annual Scientific Retreat, Nemacolin, PA.

Fedorchak, M., Connor, I.P., Schuman, J.S., and Little, S.R., 2015, "Preclinical testing of a novel drug delivery system for glaucoma.," Society for Biomaterials, Charlotte, NC.

Fedorchak, M.V., Conner, I.P., Schuman, J.S., and Little, S.R., 2015, "The Monthly Eye Drop: Development of a novel controlled release system for glaucoma," Association for Ocular Pharmacology and Therapeutics, Charleston, SC.

Fedorchak, M.V., Connor, I.P., Schuman, J.S., and Little, S.R., 2015, "Update on the Monthly Eye Drop for glaucoma," McGowan Institute for Regenerative Medicine Annual Retreat, Farmington, PA.

Garlet, G.P., and Little, S.R., 2015, "MyD88 mediates inflammatory and healing/regenerative responses to classic biomaterials (Ti): evidences for DAMPs as host response triggers," Hilton Head Regenerative Medicine Workshop, Hilton Head, SC.

Gottardi, R., Bianconi, P.A., Manner, P.A., Alexander, P.G., Tuan, R.S., and Little, S.R., 2015, "Prevention of Articular Cartilage Calcification by Controlled Release of Dorsomorphin," Penn Orthopedics Cartilage Repair Symposium, Philadelphia, PA.

Guaragno, M., Gottardi, R., Fedorchak, M.V., Tan, S., Balazs, A.C., and Little, S.R., 2015, "Zero-dimensional Single-Walled Nanotubes as Synthetic Ion Channels," McGowan Institute for Regenerative Medicine Scientific Retreat, Farmington, PA.

Bayer, E., Blanchard, E., Fedorchak, M.V., Roy, A., Kumta, P., and Little, S.R., 2014, "Choeographing Regeneration with BoneSCRIPT," McGowan Institute for Regenerative Medicine Annual Scientific Retreat, Nemacolin, PA.

Bayer, E., Blanchard, E., Fedorchak, M.V., Roy, A., Kumta, P., and Little, S.R., 2014, "Choeographing Regeneration with BoneSCRIPT," University of Pittsburgh Department of Pathology Research Day, Pittsburgh, PA.

Fisher, J.D., Schweizer, R., Unadkat, J.V., Fries, A., Komatsu, C., Oksuz, S., Solari, M.G., Davis, M., Gorantla, V.S., and Little, S.R., 2014, "Establishing Dominant Tolerance in Vascularized Composite Allotransplantation via Biomimetic Lymphocyte Enriching Microparticles," 60h Annual Scientific Meeting of the Robert H. Ivy Society of Plastic Surgeons, Pittsburgh, PA.

Fisher, J.D., Schweizer, R., Unadkat, V., Komatsu, C., Oksuz, S., Solari, M., Gorantla, V.S., and Little, S.R., 2014, "Tumor Inspired Microparticle Formulations for Preventing Vascularized Composite Allotransplant Rejection," University of Pittsburgh Department of Plastic Surgery Resident Research Day, Pittsburgh, PA.

Fisher, J.D., Unadkat, J.V., Schweizer, R., Komatsu, C., Oksuz, S., Solari, M., Gorantla, V.S., and Little, S.R., 2014, "Emulating Nature's Genius: Engineered Biomimetic Formulations for Suppressing Rejection in Vascularized Composite Allotransplantation," Ohio Valley Society of Plastic Surgeons 57th Annual Meeting, Greenbrier WV.

Glowacki, A.J., Yoshizawa, S.A., Jhunjhunwala, S., Vieira, A.E., Garlet, G.P., Sfeir, C., and Little, S.R., 2014, "Treating periodontal disease by targeting immune dysfunction," McGowan Institute for Regenerative Medicine Annual Scientific Retreat, Nemacolin, PA.

Gottardi, R., Bianconi, P., Manner, P., Alexander, P., Tuan, R.S., and Little, S.R., 2014, "Prevention of Articular Cartilage Hypertrophy by Controlled Release of Dorsomorphin," McGowan Institute for Regenerative Medicine Annual Scientific Retreat, Nemacolin, PA.

Guaragno, M., Gottardi, R., Fedorchak, M.V., Roy, A., Kumta, P., and Little, S.R., 2014, "Fluorescently Labeled Single-Walled Carbon Nanotubes for Synthetic Ion Channels," Department of Bioengineering Day, Pittsburgh, PA.

Guaragno, M., Gottardi, R., Fedorchak, M.V., Tan, S., Balazs, A., and Little, S.R., 2014, "Fluorescent Single-Walled Nanotubes for Synthetic Ion Channels," McGowan Institute for Regenerative Medicine Annual Scientific Retreat, Nemacolin, PA.

Lash, M.H., Jordan, J.C., Mccarthy, J.J., Fedorchak, M.V., and Little, S.R., 2014, "Self-Assembly of Binary Colloidal Crystals for the Production of Inverted Crystalline Scaffolds," McGowan Institute for Regenerative Medicine Annual Scientific Retreat, Nemacolin, PA.

Mahoney, C., Fedorchak, M.V., Rothstein, S., and Little, S.R., 2014, "Engineering Antigen Delivery Kinetics in Microparticle-based Vaccines for the Development of Protective Immunity," McGowan Institute for Regenerative Medicine Annual Scientific Retreat, Nemacolin, PA.

Little, S., 2013, "Controlling Controlled Release from Biodegradable Systems," University of Minnesota, IPRIME, Minneapolis, MN.

Balmert, S.C., Vu, J.R., Jhunjhunwala, S., Vieira, A.E., Garlet, G.P., Sfeir, C., and Little, S.R., 2013, "Suppression of Local Inflammation with Engineered Treg-Inducing Microparticle Systems," McGowan Institute for Regenerative Medicine Annual Scientific Retreat, Farmington, PA.

Bayer, E., DeSantis, D., Blanchard, E., Fedorchak, M., Roy, A., Kumta, P., and Little, S.R., 2013, "Composite Micro-CaP Scaffold for Bone Regeneration," University of Pittsburgh Department of Pathology Research Day, Pittsburgh, PA.

Gottardi, R., Hwang, M.P., Simson, M., Manner, P.A., Tan, J., Alexander, P.G., Little, S.R., and Tuan, R.S., 2013, "Autologous Stem Cell Recruitment for Articular Cartilage Regeneration," TERMIS-AM: Annual Conference, Las Vegas, NV.

Gottardi, R., Simson, M., Manner, P., Tan, J., Alexander, P., and Little, S.R., 2013, "Autologous Stem Cell Recruitment for Articular Cartilage Regeneration," McGowan Institute for Regenerative Medicine Annual Scientific Retreat, Nemacolin, PA.

Lash, M.H., McCarthy, J.J., and Little, S.R., 2013, "Fabrication of Highly Ordered and Close Packed Colloidal Crystals from Large Microparticles for Biomedical Applications," McGowan Institute for Regenerative Medicine Annual Retreat, Farmington, PA.

Little, S., 2012, "Advanced Controlled Release Systems for Next Generation Ophthalmic Therapy," Fox Center Conference, Pittsburgh, PA.

Little, S., 2012, "Can Restoring Immunological Homeostasis in the Periodontium Lead to Regeneration?," 18th Annual Hilton Head Workshop, Hilton Head, South Carolina.

Little, S., 2012, "Can Restoring Immunological Homeostasis in the Periodontium Lead to Regeneration?," Materials, Science, & Technology Annual Meeting, Pittsburgh, PA.

Little, S., 2012, "Controlled Release Systems for Next Generation Ophthalmic Therapy," Gordon Research Conference on Biology and Pathobiology of the Cornea, Ventura, California.

Little, S., 2012, "Medicine that Imitates Life Through Biomimetic Drug Delivery," KEYNOTE: Society of Analytical Chemists of Pittsburgh Regional Meeting, Pittsburgh, PA.

Little, S., 2012, "Medicine that Imitates Life Through Biomimetic Drug Delivery," PLENARY: Induction Conference for 2012 Beckman Young Investigators, Irvine, CA.

Little, S., 2012, "Medicine that Imitates Life Through Biomimetic Drug Delivery," Senior Vice-Chancellor's Distinguished Lecture, Pittsburgh, PA.

Little, S., 2012, "Medicine that Imitates Life Through Biomimetic Drug Delivery," Syracuse University and SUNY, Syracuse, NY.

Little, S., 2012, "Medicine that Imitates Life Through Biomimetic Drug Delivery," University of Texas, Austin, Austin, TX.

Little, S., 2012, "Medicine that Imitates Life Through Biomimetic Drug Delivery," Vanderbilt University, Nashville, TN.

Little, S., 2012, "Nanomedical Approaches to Drug Delivery. In Reconstructive Transplantation: What's on the Horizon?," PENARY: American Society for Reconstructive Transplantation Annual Meeting, Chicago, IL.

Little, S., 2012, "Rationally designed controlled release systems for periodontal disease that promote immunological homeostasis," Symposium on Polymers at the Interface of Biology, Philadelphia, PA.

Little, S., 2012, "Treatments for Periodontal Disease that Recruit Regulatory T-cells," Materials Research Society Fall Meeting, Tampa, Florida.

Balmert, S.C., Jhunjhunwala, S., Raimondi, G., Dons, E., Nichols, E.E., Thomson, A.W., and Little, S., 2012, "Biomimetic Microparticle Systems to Promote Local Immune Tolerance," McGowan Institute for Regenerative Medicine Retreat, Farmington, PA.

Balmert, S.C., Jhunjhunwala, S., Raimondi, G., Vu, J., Falo, L., Thomson, A., and Little, S., 2012, "Sustained Release Systems to Locally Expand Regulatory T Cell Populations and Suppress Inflammation," AIChE Annual Meeting, Pittsburgh, PA.

Balmert, S.C., Jhunjhunwala, S., Raimondi, G., Vu, J.R., Thomson, A.W., Falo, L.D., and Little, S., 2012, "Controlled Release Systems to Increase Local Numbers of Regulatory T Cells and Suppress Contact Hypersensitivity," Society for Biomaterials 2012 Fall Symposium, New Orleans, LA.

Blanchard, E., DeSantis, D., and Little, S., 2012, "Developing A Controlled, Sequential Delivery System of Alginate Microparticles for the Release of Positive Growth Factors," Science 2012, Pittsburgh, PA.

Cugini, A., Fedorchak, M., and Little, S., 2012, "Developing a Hydrogel Based Ocular Insert for the Treatment of Glaucoma," Science 2012, Pittsburgh, PA.

Fedorchak, M.V., Wingard, J.B., Medina, C.A., Albeiruti, E., Schman, J.S., and Little, S., 2012, "28-Day Ocular Delivery of Brimonidine Tartrate from Rationally Designed, Degradable Microparticles in a Rabbit Model," AIChE Annual Meeting, Pittsburgh, PA.

Fedorchak, M.V., Wingard, J.B., Medina, C.A., Albeiruti, E., Schuman, J.S., and Little, S., 2012, "28-day ocular delivery of brimonidine tartrate from rationally designed degradable microparticles in a rabbit model," Association for Research in Vision and Ophthalmology Annual Meeting, Ft. Lauderdale, FL.

Fedorchak, M.V., Wingard, J.B., Medina, C.A., Albeiruti, E., Schuman, J.S., and Little, S., 2012, "Combating blindness with convenient and comfortable glaucoma treatments," McGowan Institute for Regenerative Medicine, Farmington, PA.

Fisher, J.D., Jhunjhunwala, S., Thomson, A.T., and Little, S., 2012, ""Biomimetic Sustained Release Formulations for Suppressing Composite Tissue Transplant Rejection Via Naïve, Regulatory T Cells"," McGowan Institute for Regenerative Medicine Retreat, Farmington, PA.

Fisher, J.D., Jhunjhunwala, S., Thomson, A.T., Unadkat, J.V., and Little, S., 2012, "Biomimetic Sustained Release Formulations for Suppressing Composite Tissue Transplant Rejection," Society for Biomaterials Annual Conference, New Orleans, LA.

Fisher, J.D., Jhunjhunwala, S., Thomson, A.T., Unadkat, J.V., and Little, S., 2012, "Biomimetic Sustained Release Systems for Regulating Inflammation in Composite Tissue Transplant Rejection," AIChE Annual Conference, Pittsburgh, PA.

Glowacki, A., Yoshizawa, S., Sfeir, C., Zack, J., and Little, S., 2012, "Translation of Periodontal Treatments that Restore Immunological Homeostasis," University of Pittsburgh First Look Technology Showcase, Pittsburgh, PA.

Glowacki, A.J., Yoshizawa, S., Jhunjhunwala, S., Garlet, G.P., Sfeir, C., and Little, S., 2012, "Preclinical Evaluation of Treg Recruiting Microparticles for the Treatment of Periodontitis," AIChE Annual Meeting, Pittsburgh, PA.

Glowacki, A.J., Yoshizawa, S., Zack, J., Sfeir, C., and Little, S., 2012, "Translation of periodontal treatments that restore immunological homeostasis," Science 2012 Technology Showcase, Pittsburgh, PA.

Gottardi, R., Stolz, M., Raiteri, R., Dueggelin, M., Lozito, T., Alexander, P., Little, S., and Tuan, R.S., 2012, "Cartilage degeneration and repair - seeing and operating at the nanoscale," Science 2012, Pittsburgh, PA.

Hong, Y., Little, S., and Wagner, W.R., 2012, "Developing an enzymatically-trigged, rapidly degradable polyurethane hollow fiber membrane," Biomedical Engineering Society Annual Fall Meeting, Atlanta, GA.

Hong, Y., Fu, H., Little, S., and Wagner, W.R., 2012, "Developing an enzymatically-triggered, rapidly degradable polyurethane hollow fiber membrane," BMES Annual Meeting, Atlanta, GA.

Howell, A., Balmert, S., Lash, M., Glowacki, A., and Little, S., 2012, "Patchy Particles: Inducing Surface Anisotropy for a Biomimetic Immune Synapse," Science 2012, Pittsburgh, PA.

Kamalasan, K., Gottardi, R., Tan, S., Chen, Y., Godugu, B., Rothstein, S.N., Balazs, A.C., Star, A., and Little, S., 2012, ""Zero Dimensional" Single Walled Carbon Nanotubes," AIChE Annual Meeting, Pittsburgh, PA.

Knab, T.D., Rothstein, S.N., Little, S., and Parker, R.S., 2012, "System Identification and Frequency Response Techniques for the Design of Controlled Release Drug Delivery Systems," AIChE Annual Meeting, Pittsburgh, PA.

Lash, M., Kamalssanan, K., McCarthy, J., and Little, S., 2012, "Engineering Particles to Rationally Assemble Using Surface Anisotropy-Based Information," McGowan Institute for Regenerative Medicine, Farmington, PA.

Lash, M.H., Kamalssanan, K., Li, S., McCarthy, J.J., and Little, S., 2012, "Fabrication of Highly Ordered and Close Packed Colloidal Crystals From Large Microparticles," AIChE Annual Meeting, Pittsburgh, PA.

Li, S., Lash, M.H., Little, S., and McCarthy, J., 2012, "Dissipative Particle Dynamics Simulation of Sonication-Mediated Particle Interactions," AIChE Annual Meeting, Pittsburgh, PA.

Mealy, J.E., Fedorchak, M.V., and Little, S., 2012, "Development of a Controlled Release Ocular Insert for Brimonidine Tartrate," AIChE Undergraduate Student Poster Session, Pittsburgh, PA.

Patil, M., Gottardi, R., Velankar, S.S., and Little, S., 2012, "Interfacial Interactions of Zero Dimensional Carbon Nanotubes and Their Application as Thin Films: A Potential Platform for Cell Growth," AIChE Annual Meeting, Pittsburgh, PA.

Patil, M., Gottardi, R., Velankar, S.S., and Little, S., 2012, "Interfacial Interactions of Zero Dimensional Carbon Nanotubes and Their Application as Thin Films: A Potential Platform for Cell Growth," Science 2012, Pittsburgh, PA.

Raimondi, G., Jhunjhunwala, S., Nichols, E.E., Thomson, A.W., and Little, S., 2012, "All-trans Retinoic Acid and Rapamycin Synergize with Transforming Growth Factor-ß1 to Induce Regulatory T Cells but Confer Distinct in vivo Migratory Capacities," Joint Annual Meeting of the International Cytokines Society and International Society for Interferon and Cytokine Research, Geneva, Switzerland.

Rothstein, S.N., and Little, S., 2012, "Critical Quality Attributes (CQAs) of Biodegradable Polymer Matrices and Particles: Impact of a Recent Mathematical Model," AIChE Annual Meeting, Pittsburgh, PA.

Wu, T., Ngobi, L.M., Rothstein, S.N., Yutzy, S., Wiener, E., Parker, R.S., and Little, S., 2012, "Magnetic Resonance Imaging As a Powerful Tool for Visualizing Controlled Release From Biodegradable Microparticles," AIChE Annual Meeting, Pittsburgh, PA.

Yoshizawa, S., Glowacki, A.J., Little, S., and Sfeir, C., 2012, "Preclinical Evaluation of Treatments for Periodontitis that Recruit Regulatory T-cells," International Association for Dental Research, Iguaçu Falls, Brazil.

Zmolek, A., Balmert, S.C., Glowacki, A., Rothstein, S., Wokpetah, J., and Little, S., 2012, "Analyzing the Release Kinetics of 'Sticky' Peptides from PLGA (Poly(lactic-co-glycolic) acid) Microspheres," AIChE Annual Meeting, Pittsburgh, PA.

Zmolek, A., Balmert, S.C., Glowacki, A., Rothstein, S., Wokpetah, J., and Little, S., 2012, "Analyzing the Release Kinetics of 'Sticky' Peptides from PLGA (Poly(lactic-co-glycolic) acid) Microspheres," Science 2012, Pittsburgh, PA.

Zmolek, A., Balmert, S.C., Glowacki, A., Rothstein, S., Wokpetah, J., and Little, S., 2012, "Defining the Role of Peptide Charge on Release Kinetics from PLGA (Poly(lactic-co-glycolic) acid) Microspheres," AiChE Regional Conferences 2012, Hoboken, NJ.

Zmolek, A., Balmert, S.C., Glowacki, A., Rothstein, S., Wokpetah, J., and Little, S., 2012, "Defining the Role of Peptide Charge on Release Kinetics from PLGA (Poly(lactic-co-glycolic) acid) Microspheres," URC-PA: Undergraduate Research at the Capitol, Harrisburg, PA.

Little, S., 2011, "Anisotropic, Patchy Microspheres with Soft Protein Islets," Materials Research Society Fall Meeting, Boston, MA.

Little, S., 2011, "Anisotropic, Patchy Microspheres with Soft Protein Islets," Materials Research Society Spring Meeting, San Francisco, CA.

Little, S., 2011, "Biomimetic Controlled Release Formulations that Prolong Survival of Whole Limb Transplants," McGowan Institute for Regenerative Medicine, Farmington, PA.

Little, S., 2011, "Engineering the Next Generation of Cell Interactive Medicine," KEYNOTE: Youngstown State University QUEST Regional Symposium, Youngstown.

Little, S., 2011, "Medicine that Imitates Life Through Biomimetic Drug Delivery," Carnegie Mellon University, Pittsburgh, PA.

Little, S., 2011, "Medicine that Imitates Life Through Biomimetic Drug Delivery," Case Western University.

Little, S., 2011, "Medicine that Imitates Life Through Biomimetic Drug Delivery," University of Florida, Florida.

Balmert, S.C., Jhunjhunwala, S., and Little, S., 2011, "Biomimetic Microparticle-Based System to Induce Local Immune Tolerance In Vivo," McGowan Institute for Regenerative Medicine Retreat, Farmington, PA.

Glowacki, A., Jhunjhunwala, S., Garlet, G., Sfeir, C., and Little, S., 2011, "Recruiting Regulatory T-cells to Treat Periodontitis and Promote Regeneration," AADR Annual Meeting, San Diego, CA.

Glowacki, A., Jhunjhunwala, S., Garlet, G., Sfeir, C., and Little, S., 2011, "Recruiting Regulatory T-cells to Treat Periodontitis and Promote Regeneration," McGowan Institute for Regenerative Medicine, Farmington, PA.

Hwang, M., and Little, S., 2011, "Controlled Delivery of CCL5 Induces MC3T3-Osteoblastic Chemotaxis and Survival," McGowan Institute for Regenerative Medicine Retreat, Farmington, PA.

Jhunjhunwala, S., Raimondi, G., Hall, S., Thorne, S.H., Thomson, A.W., and Little, S., 2011, "Bio-inspired Controlled Release for Regulatory T Cell Recruitment in vivo," The American Association of Immunologist, Immunology 2010, Baltimore, MD.

Jhunjhunwala, S., Raimondi, G., Nichols, E., Thorne, S., Thomson, A., and Little, S., 2011, "Biomimetic sustained release formulation for modeling local immune responses," Materials Research Society, San Francisco, CA.

Jhunjhunwala, S., Raimondi, G., Nichols, E., Thorne, S.H., Thomson, A.W., and Little, S., 2011, "Controlled Release Formulations for Increasing Local Numbers of Regulatory T Cells," Society for Biomaterials Annual Meeting, Orlando, FL.

Kamalasanan, K., and Little, S., 2011, "Synthetic Cells with Ordered Protein Patches," Society for Biomaterials Annual Meeting, Orlando, FL.

Kamalasanan, K., Jhunjhunwala, S., Swanson, A., Wu, J., Gao, D., and Little, S., 2011, "Synthetic Cells with Ordered Protein Patches," PINCE Research Fair, Pittsburgh, PA.

Ma, Z., Hong, Y., Nelson, D.M., Tengood, J., Little, S., and Wagner, W.R., 2011, "Biodegradable poly(urethane urea) (PUU) elastomers with diverse properties for biomedical applications," McGowan Institute for Regenerative Medicine Retreat, Farmington, PA.

Ngobi, L., Rothstein, S., Little, S., and Parker, R., 2011, "Exploring New Techniques for "Fingerprint" the Barriers to Controlled Release In Vivo," McGowan Institute for Regenerative Medicine Retreat, Farmington, PA.

Raimondi, G., Jhunjhunwala, S., Brandisher, G., Thomson, A.W., and Little, S., 2011, "Biomimetic Controlled Release of CCL22 for In Vivo Recruitment of Regulatory T Cells and Prolongation of Allograft Survival," American Transplant Congress, Philadelphia, PA.

Tengood, J., Federspiel, W., and Little, S., 2011, "Release of Angiogenic Growth Factors from Porous Hollow Fiber Membranes," McGowan Institute for Regenerative Medicine Retreat, Farmington, PA.

Wu, T., Ngobi, L., Rothstein, S., Parker, R., and Little, S., 2011, "A Compartmental Model of Controlled Release that Accounts for Multiple Barriers to Micro-Needle-Based Transdermal Drug Delivery," McGowan Institute for Regenerative Medicine Retreat, Farmington, PA.

Little, S., 2010, "Biomimetic Drug Delivery," McGowan Institute for Regenerative Medicine Retreat, Farmington, PA.

Little, S., 2010, "Polymeric Microcapsulates as a Platform Technology for Biomimetic Drug Delivery," Duquesne University, Pittsburgh, PA.

Little, S., 2010, "Polymeric particles as a platform for biomimetic drug delivery," Particles 2010, Lake Buena Vista, FL.

Little, S., 2010, "Rationally designed biomimetic delivery system for Immunosuppression," American Chemical Society National Meeting, Boston, MA.

Little, S., 2010, "Regenerating Periodontal Structures Through Recruitment of Regulatory Lymphocytes," ICRE Annual Meeting, Washington DC.

Balazs, A., Dutt, M., Kuksenok, O., and Little, S., 2010, "Modeling the Interactions Between Amphiphilic Nanotubes and Lipid Bilayers," Materials Research Society Spring Meeting, San Francisco, CA.

Dutt, M., Kuksenok, O., Little, S., and Balazs, A., 2010, "Forming Trans-Membrane Channels Using End-Functionalized Nanotubes," AIChE Annual Meeting, Salt Lake City, UT.

Dutt, M., Nayhouse, M., Kuksenok, O., and Little, S., 2010, "Design of Synthetic Vehicles through Self-Assembly of End-Functionalized Nanotubes and Lipids," AIChE Annual Meeting, Salt Lake City, UT.

Fierro, J.A., Ramirez, V., Silvia, C., Ruiz, P., Gleisner, A., Morales, J., Jhunjhunwala, S., Little, S., Bono, M.R., and Rosemblatt, M., 2010, "Transference of Phagosomes in an Allogeneic Immunisation Protocol Down Regulates the Production of anti-MHC Antibodies and T Cell Mediated Alloreactivity," American Transplant Congress, San Diego, CA.

Glowacki, A., Jhunjhunwala, S., Garlet, G., Sfeir, C., and Little, S., 2010, "Treating Periodontal Disease through the Recruitment of Regulatory Lymphocytes," AIChE, Salt Lake City, UT.

Glowacki, A., Jhunjhunwala, S., Gustavo, G., Sfeir, C., and Little, S., 2010, "Treating Periodontal Disease through Recruitment of Regulatory Lymphocytes," AIChE Annual Meeting, Salt Lake City, UT.

Glowacki, A., Jhunjhunwala, S., Gustavo, G.P., Sfeir, C., and Little, S., 2010, "Treating Periodontitis through recruitment of regulatory lymphocytes," McGowan Institute for Regenerative Medicine Retreat, Farmington, PA.

Hofer, H., Sfeir, C., and Little, S., 2010, "Biomaterial-associated osteogenesis in vitro," McGowan Institute for Regenerative Medicine Retreat, Farmington, PA.

Hwang, M.P., and Little, S., 2010, "Controlled Delivery of Platelet-Derived Growth Factor Induces MC3T3-E1-Osteoblastic Cell Proliferation and Chemotaxis," McGowan Institute for Regenerative Medicine Retreat, Farmington, PA.

Jhunjhunwala, S., Raimondi, G., Hall, S., Thorne, S., Thomson, A., and Little, S., 2010, "Bio-inspired controlled release for the recruitment of regulatory T cells," McGowan Institute for Regenerative Medicine Retreat, Farmington, PA.

Kamalasanan, K., and Little, S., 2010, "Anisotropic Protein Patterned Microspheres," AIChE Annual Meeting, Salt Lake City, UT.

Kamalasanan, K., and Little, S., 2010, "Self-Assembly of Quantum Single Walled Carbon Nanotubes," AIChE Annual Meeting, Salt Lake City, UT.

Rothstein, S., and Little, S., 2010, "Augmenting Biologics with Cost-Effective Controlled Release Formulations," AIChE Annual Meeting, Salt Lake City, UT.

Rothstein, S., and Little, S., 2010, "Rationally Designed Controlled Release Therapeutics," AIChE Annual Meeting, Salt Lake City, UT.

Rothstein, S.N., and Little, S., 2010, "Customizing Timed Release Formulations: a Visual Whitepaper for ChroKnow(r) Solutions," McGowan Institute for Regenerative Medicine Retreat, Farmington, PA.

Rothstein, S.N., and Little, S., 2010, "Engineering sustained release in therapeutics," University of Pittsburgh Science Technology Showcase, Pittsburgh, PA.

Tengood, J., Russell, A., and Little, S., 2010, "Sequential Delivery of Angiogenic Growth Factors," McGowan Institute for Regenerative Medicine Retreat, Farmington, PA.

Tengood, J., Russell, A., and Little, S., 2010, "Sequential Delivery of VEGF and S1P for Angiogenesis," Society for Biomaterials Annual Meeting, Seattle, WA.

Little, S., 2009, "Controlling Controlled Release from Biodegradable Systems," University of Pittsburgh, Pittsburgh, PA.

Little, S., 2009, "Controlling Controlled Release from Biodegradable Systems," US-Japan Symposium on Drug Delivery Systems, Lahaina, HA.

Little, S., 2009, "Polymeric Microcapsulates as a Platform Technology for Biomimetic Drug Delivery," Auburn University.

Little, S., 2009, "Polymeric Microcapsulates as a Platform Technology for Biomimetic Drug Delivery," Materials, Science, & Technology Annual Meeting 2009, Pittsburgh, PA.

Little, S., 2009, "Polymeric Microcapsules: Theory, Experiment and Applications," American Chemical Society National Symposium.

Glowacki, A., Jhunjhunwala, S., Garlet, G., Sfeir, C., and Little, S., 2009, "Regenerating Periodontal Structures Through Recruitment of Regulatory Lymphocytes," Biomedical Engineering Society Annual Fall Meeting, Pittsburgh, PA.

Hofer, H., Sfeir, C., and Little, S., 2009, "Biocompatibility of a Gene Delivery Vehicle for Bone Tissue Engineering," Biomedical Engineering Society Annual Fall Meeting, Pittsburgh, PA.

Jhunjhunwala, S., Hall, S., Raimondi, G., Thorne, S., Garlet, G., Thomson, A., and Little, S., 2009, "Developing Controlled Release Formulations for Regulatory T cell Recruitment," Biomedical Engineering Society Annual Fall Meeting, Pittsburgh, PA.

Jhunjhunwala, S., Raimondi, G., Thomson, A., and Little, S., 2009, "Controlled Release for Recruitment of Regulatory T cells," Keystone Regulatory T-cell Conference, Keystone, CO.

Kamalasanan, K., and Little, S., 2009, "Dual Protein Patterning of Microspheres for Therapeutics, Biosensor, and Photonic Applications," Biomedical Engineering Society Annual Fall Meeting, Pittsburgh, PA.

Kamalasanan, K., and Little, S., 2009, "Modeling the Interactions of Amphiphilic Nanotubes and Lipid Bilayers, Self-Assembled Biomaterials," AIChE Annual Meeting, Nashville, TN.

Karunanidhi, A., and Little, S., 2009, "Evaluation of PDGF- BB for Osteo-Angiogenic Effects Using 3D-Speroidial Coculture Model," Biomedical Engineering Society Annual Fall Meeting, Pittsburgh, PA.

Rothstein, S., and Little, S., 2009, "Engineering Efficacious Controlled Release Therapeutics, Meet the Faculty Candidate," AIChE Annual Meeting, Nashville, TN.

Rothstein, S., and Little, S., 2009, "Engineering Sustained Release in Therapeutics," Biotech2009, Mid-Atlantic Region Biosciences Annual Meeting, Philadelphia, PA.

Rothstein, S., and Little, S., 2009, "In Vivo Evaluation of Rationally Designed Single Injection Vaccine, Disease Therapies," AIChE Annual Meeting, Nashville, TN.

Rothstein, S., and Little, S., 2009, "Translation of In Silico Controlled Release Predictions into Rationally Designed Therapeutic Formulations," Biomedical Engineering Society Annual Meeting, Pittsburgh, PA.

Roy, A., Jhunjhunwala, S., Little, S., and Kumta, P., 2009, "Calcium Phosphate-Poly(lactic-co-glyolic) Acid Composite Cements for Bone Regeneration," Biomedical Engineering Society Annual Fall Meeting, Pittsburgh, PA.

Roy, A., Jhunjhunwala1, S., Little, S.R., and Kumta, P., 2009, "Calcium Phosphate-Poly(lactic-co-glycolic acid) Composite Cements for Bone Regeneration," Biomedical Engineering Society Annual Meeting, Pittsburgh, PA, USA.

Tengood, J., Russell, A., and Little, S., 2009, "Temporal Delivery of Angiogenic Growth Factors, Biomedical Engineering," Society Annual Fall Meeting, Pittsburgh, PA.

Little, S., 2008, "Non-Viral Delivery of Genetic Vaccines to Dendritic Cells," Drug and Nucleic Acid Delivery Symposium, Pittsburgh, PA.

Gleisner, A., Ureta, G., Moore, C., Morales, J., Rosemblatt, M., Bono, M.R., Morelli, A., Jhunjhunwala, S., Little, S., and Fierro, A., 2008, "Phagosomes Derived from Dendritic Cells Down-regulate Adaptive Immune Responses In Vivo," American Society for Transplantation, Toronto, Ontario, Canada.

Jhunjhunwala, S., Raimondi, G., Thomson, A.W., and Little, S., 2008, "Delivery of Rapamycin to Dendritic Cells using Degradable Microparticles," Experimental Biology 2008, San Diego, CA.

Rothstein, S.N., Federspiel, W., and Little, S., 2008, "A Unified Mathematical Model for Predicting Controlled Release from Surface and Bulk Eroding Matrices without Regression," AIChE 2008 Annual Meeting, Philadelphia, PA.

Rothstein, S.N., Federspiel, W., and Little, S., 2008, "Towards the Rational Design of Biodegradable Controlled Release Vehicles," AIChE 2008 Annual Meeting, Philadelphia, PA.

Rothstein, S.N., Federspiel, W., and Little, S., 2008, "Towards the Rational Design of Controlled Release Therapeutics," AIChE 2008 Annual Meeting, Philadelphia, PA.

Rothstein, S.N., Federspiel, W., and Little, S.R., 2008, "Towards the Rational Design of Controlled Release Therapeutics," Biotechnology and Bioengineering Research Symposium, Biomedical Engineering Graduate Society Symposium, Carnegie Mellon University, Pittsburgh, Pennsylvania.

Tengood, J., Russell, A., Wagner, W., and Little, S., 2008, "Sequential Delivery of Growth Factors to Improve Angiogenesis," 8th World Bio Materials Congress, Amsterdam, The Netherlands.

Yadav, S., van Vlerken, L., Little, S., Langer, R., and Amiji, M., 2008, "Multifunctional Nanosystems for MDR-1 Gene Silencing and Chemotherapy Administration to Overcome Drug Resistance," Bio International Convention, Boston, MA.

Rothstein, S.N., Federspiel, W., and Little, S.R., 2007, "A Simple Model for Predicting Controlled Release From Biodegradable Polymer Matrices," Society for Biomaterials Annual Spring Meeting, Chicago, IL.

Tengood, J., and Little, S., 2007, "Dissolvable, Synthetic Vasculature Poster Session," BMES 2007, Los Angeles, CA.

Little, S., 2006, "Functional, Non-Viral Genetic Vaccine Vectors," Biomaterials Group, University of Pittsburgh, Pittsburgh, PA.

Little, S., 2006, "Functional, Non-Viral Genetic Vaccine Vectors," Thomas E. Starzl Transplantation Institute.

Little, S., 2006, "High-Throughput Fabrication of Polymeric Microparticles," AIChE Annual Meeting, San Francisco, CA.

Little, S., 2006, "Overcoming Challenges in the Non-Viral Delivery of Genetic Vaccines," Society for Biomaterials National Meeting.

Little, S., 2006, "Overcoming Challenges in the Non-Viral Delivery of Genetic Vaccines," Youngstown State University.

Rothstein, S., Federspiel, W., and Little, S., 2006, "Predictive Model for Release from a Polymeric Microparticle," AIChE Annual Meeting, San Francisco, CA.

Rothstein, S.N., Federspiel, W., and Little, S., 2006, "Finite Element Model of Controlled Release Via the Degradation and Erosion of a Polymer Matrix," AIChE 2006 Annual Meeting, San Francisco, CA.

Little, S., 2005, "High Throughput Fabrication of Polymeric Microparticles," US-Japan Symposium on Drug Delivery Systems.

Little, S., Anderson, D.G., and Langer, R., 2005, "High-Throughput Fabrication of Polymeric Microparticles," US-Japan Symposium on Drug Delivery Systems, Lahaina, HA.

Little, S., Lynn, D.M., Ge, Q., Anderson, D.G., Puram, S.V., Chen, J., Eisen, H.N., and Langer, R., 2005, "Novel Microparticles Enhance the Potency of Non-viral Genetic Vaccines," Basic Aspects of Tumor Immunology, Keystone, CO.

Fuller, J., Little, S., Wang, Y., Zugates, G., and Langer, R., 2005, "Non-viral Polymer Delivery Systems for Immune Modulation," Basic Aspects of Tumor Immunology, Keystone, CO.

Fuller, J., Little, S., Zugates, G.T., and Langer, R., 2005, "Immune Targeted Delivery for Tumor Therapy," US-Japan Symposium on Drug Delivery Systems, Lahaina, HA.

Wood, K.C., Little, S., Langer, R., and Hammond, P.T., 2005, "A New Family of Hierarchically Self-Assembling Linear-Dendritic Hybrid Polymers for Targeted Gene Delivery," US-Japan Symposium on Drug Delivery Systems, Lahaina, HA.

Zugates, G., Little, S., Fuller, J., and Langer, R., 2005, "Controlled Release of CCL22 from Biodegradable Microparticles as a Model of Tumor Induced Chemotaxis of Regulatory T-cells," Basic Aspects of Tumor Immunology, Keystone, CO.

Zugates, G., Anderson, D.G., Little, S., and Langer, R., 2005, "Synthesis of Functionalized Poly(Beta- Amino Ester)s for Targeted Gene Delivery," US-Japan Symposium on Drug Delivery Systems, Lahaina, HA.

Little, S., 2004, "Enhancing Microparticulate Genetic Vaccine Delivery using Poly-Beta Amino Esters," Zycos (MGI Pharmaceuticals).

Little, S., Lynn, D.M., Ge, Q., Anderson, D.G., Puram, S.V., Chen, J., Eisen, H.N., and Langer, R., 2004, "Novel Microparticles Enhance the Potency of Non-viral Genetic Vaccines," Cancer Immunotherapeutics Conference, Boston, MA.

Little, S., 2003, "Functional, Non-Viral Genetic Vaccine Vectors," MIT Cancer Research Center.

Little, S., Anderson, D.G., Lynn, D.M., Puram, S.V., and Langer, R., 2003, "Formulation of Poly-Beta Amino Ester Microparticles for the Delivery of Genetic Vaccines," MIT Bioprocessing and Engineering Center Industry Conference, Cambridge, MA.

Little, S., Lynn, D.M., Ge, Q., Anderson, D.G., Puram, S.V., Chen, J., Eisen, H.N., and Langer, R., 2003, "Novel Microparticles Enhance the Potency of Non-viral Genetic Vaccines," US-Japan Symposium on Drug Delivery Systems, Lahaina, HA.

Choleris, E., Little, S., Mong, J.A., Langer, R.S., and Pfaff, D.W., 2003, "Antisense DNA against Oxytocin Receptor mRNA from Microspheres in the Medial Amygdale Blocked Social Recognition in Female Mice," Annual Meeting of the Society for Neuroscience, New Orleans, LA.

Little, S., Lynn, D.M., and Langer, R., 2002, "Poly-Beta Amino Ester Microparticles for Genetic Vaccine Delivery," MIT Bioprocessing and Engineering Center Industry Conference, Cambridge, MA.

Little, S., Lynn, D.M., and Langer, R., 2001, "Functional, Non-Viral Genetic Vaccine Vectors," MIT Bioprocessing and Engineering Center Industry Conference, Cambridge, MA.

"Suppression of Local Inflammation with Engineered Treg-Inducing Microparticle Systems," McGowan Institute for Regenerative Medicine Annual Scientific Retreat, Farmington, PA.

"Zero Dimensional Single-Walled Nanotubes as Synthetic Ion Channel," Bioengineering Dat, University of Pittsburgh.

Little, S., "Controlling Controlled Release from Biodegradable Systems," Massachusetts Institute of Technology, Boston, MA.

Little, S., "Medicine that Imitates Life Through Biomimetic Drug Delivery," Johns Hopkins University, Baltimore, MD.

Little, S., "Biomimetic Cell Constructs for Celiac's Disease," provisional.

Little, S., "Controlled Release Formulations For The Induction And Proliferation of Regulatory T Cells," provisional.

Little, S., "Controlled Release Formulations for Severe Allergy Treatment," provisional.

Little, S., "Controlled Release Formulations for Sunless Tanning," provisional.

Little, S., "Controlled Release Temporary Tattoo as an Insect Repellant," provisional.

Little, S., "Dermal Sustained Release of Retinol from Micro-needles," provisional.

Little, S., "Engineered Microparticles for Macromolecule Delivery," US App #10816175.3.

Little, S., "Hierarchically Self-Assembling Linear-Dendritic Hybrid Polymers For Delivery Of Biologically Active Agents," US 11/473806.

Little, S., "High-Throughput Fabrication of Microparticles Containing Active Plasmid DNA," US 12/094,098.

Little, S., "Methods to Prepare Patchy Particles," US App #13/500,890.

Little, S., "Recruitment of Mesenchymal Stem Cells Using Controlled Release Systems," provisional.

Little, S., "Respiratory Delivery of Palmitate to Reduce Risk of Emphysema for Smokers," provisional.

Little, S., "Synthetic Cell Constructs for Cellular Manipulation," US App #13/383,122.

Little, S., "Thermoresponsive Hydrogel Containing Polymer Microparticles for Noninvasive Ocular Delivery," provisional.

Little, S., "Triggerably Dissolvable Hollow Fibers for Controlled Delivery," US 2008/077675.

Little, S., "Triggered Release of Ocular Therapeutics from Contact Lenses," provisional.

Little, S., "pH Triggered Polymeric Microparticles," US 11/002,542.