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Publications

  1. Schweitzer N, Cover C, Aizenstein H, Wu M, Vazquez A, Iordanova B. Near-lifespan mesoscopic optical imaging of cerebrovascular function reveals age and sex differences in preclinical Alzheimer’s Disease model. Brain Communications. (2025) 
  2. Shen Y, Schweitzer N, Cover C, Vazquez AL and Iordanova B. Red blood cell velocity in brain capillaries is associated with cerebral amyloid angiopathy load. Biomedical Optics (2024). 
  3. Schweitzer N, Son SJ, Thurston R, Li J, Chen CL, Howard Aizenstein, Yang S, Iordanova B, .. Minjie Wu. Sex-Specific risk factors and clinical dementia outcomes for white matter hyperintensities in a large South Korean cohort. Alzheimer’s Research & Therapy (2024) 
  4. Schweitzer N, Son SJ, Aizenstein H, Yang S, Iordanova B, Minjie Wu. Higher HbA1c is associated with greater two-year progression of white matter hyperintensities. Diabetes. (2024). 
  5. Schweitzer N, Li J, Thurston R, Lopresti B, Klunk W, Snitz B, Tudorascu D, Cohen A, Kamboh M, Halligan-Eddy E, Iordanova B, Villemagne V, Aizenstein H and Wu M. Sex-dependent alterations in hippocampal connectivity are linked to cerebrovascular and amyloid pathologies in normal aging. Alzheimer's Dement. 20: 914–924 (2024). 
  6. Li J, Stetten D, Schweitzer N, Shi Z, Ibrahim T, Yang S, Iordanova B, Aizenstein HJ and Wu M. Age- and Sex-Related Morphological Changes in Cerebral Blood Vessels: a 7T TOF MRA Study. Alzheimer's Dement. (2023) 
  7. Wu M, Schweitzer N, Iordanova B, Halligan-Eddy E, Tudorascu DL, Mathis CA, Lopresti BJ, Kamboh MI, Cohen AD, Snitz BE, Klunk WE, Aizenstein HJ. In Pre-Clinical AD Small Vessel Disease is associated with altered hippocampal connectivity and atrophy. Am J Geriatric Psychiatry. (2023). 
  8. Oghifobibi O, Toader A, Nicholas M, Nelson B, Wolf M, Kline A, Nouraie S, Bondi C, Iordanova B, Clark R, Bayir H, Loughran P, Watkins S, Croix C, Kochanek P, Vazquez A, Manole M. Resuscitation with epinephrine worsens capillary no-reflow after experimental pediatric cardiac arrest: in vivo multiphoton microscopy evaluation. J Cereb Blood Flow Metabolism. Dec 42(12):2255-2269. (2022).  
  9. Fitz N, Nam K, Wolfe C, Letronne F, Playso B, Iordanova B, Kozai T, Biedrzycki R, Kagan V, Tyurina Y, Han X, Lefterov I, Koldamova R. Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer's disease. Nature Communications. Jun 7;12(1):3416 (2021) 
  10. Poplawsky AJ, Iordanova B, Vazquez AL, Kim SG, Fukuda M. Postsynaptic activity of inhibitory neurons evokes hemodynamic fMRI responses. Neuroimage.  Jan 15; 225:117457. (2020) 
  11. Iordanova B, Fukuda M, Klunk W, Vazquez AL. Vascular and metabolic dysfunctions in APP/PS1 mouse model of Alzheimer's disease. J Cereb Blood Flow Metabolism. Jul 1(14), (2019). 
  12. Iordanova B, Vazquez A, Kozai T, Fukuda H, Kim SG. Optogenetic investigation of the variable neurovascular coupling along the interhemispheric circuits. J Cereb Blood Flow Metabolism. Apr; 38(4):627-640. (2018). 
  13. Jin T, Iordanova B, Hitchens KT, Modo M, Wang P, Mehrens H, Kim SG. Chemical exchange-sensitive spin-lock MRI of glucose and analogs in brain tumors. Magn Reson Med Aug;80(2):488-495. (2018). 
  14. Iordanova B, Li L, Clark RS, Manole MD. Alterations in cerebral blood flow after resuscitation from cardiac arrest. Frontiers in Pediatrics Aug 16;5:174 (2017). 
  15. Iordanova B, Murphy MC, Klunk WE and Vazquez AL. In vivo NADH fluorescence imaging of double transgenic Alzheimer’s Disease mice reveals chronic tissue hypoxia. Alzheimer's & Dementia 12(7): P1047-P1048. (2016). 
  16. Iordanova B, Vazquez AL, Poplawsky A, Fukuda M, Kim SG. Neural and hemodynamic responses to optogenetic and sensory stimulation in the rat somatosensory cortex. J Cereb Blood Flow Metabolism. Jun;35(6):922-32. (2015). 
  17. Iordanova B, Hitchens TK, Robison C, Ahrens ET. Engineered mitochondrial ferritin as a magnetic resonance imaging reporter in mouse olfactory epithelium. PLoS One. Aug 30;8(8) (2013). 
  18. Iordanova B, Goins WF, Clawson DS, Hitchens TK, E.T. Ahrens ET.. Quantification of HSV1-mediated expression of the ferritin MRI reporter in the mouse brain. Gene Ther. Jun; 20(6):589-96. (2013). 
  19. Iordanova B, and Ahrens ET. In vivo magnetic resonance imaging of ferritin-based reporter visualizes native neuroblast migration. Neuroimage. Jan 16;59(2):1004-12 (2012). 
  20. Iordanova B and Ahrens ET. Chapter 26: MR reporter gene imaging of cancer. Molecular Imaging Probes for Cancer Research. Editor: Xiaoyuan Chen (NIH, USA). WSPC; 1 ed. (April 28, 2012). 
  21. Iordanova B, Robison CS, Goins WF, Ahrens ET. Single chain ferritin chimera as an improved MRI gene reporter. Prilozi. 31(2):151-5 (2010). 
  22. Iordanova B, Robison CS, Ahrens ET. Design and characterization of a chimeric ferritin with enhanced iron loading and transverse NMR relaxation rate. J Biol Inorg Chem. 15(6):957-65 (2010).  
  23. Iordanova B, Rosenbaum D, Norman D, Weiner M, Studholme C. MR imaging anatomy in neurodegeneration: a robust volumetric parcellation method of the frontal lobe gyri with quantitative validation in patients with dementia. Am J Neuroradiol. Sep;27(8):1747-54 (2006). 
  24. Rousseau F, Glenn OA, Iordanova B, Rodriguez-Carranza C, Vigneron DB, Barkovich JA, Studholme C. Registration-based approach for reconstruction of high-resolution in utero fetal MR brain images. Acad Radiol. Sep;13(9):1072-8 (2006). 
  25. Studholme C, Drapaca C, Iordanova B, Cardenas V. Deformation-based mapping of volume change from serial brain MRI in the presence of local tissue contrast change. IEEE Trans Med Imaging. May; 25:626-39 (2006). 
  26. Rodriguez-Carranza C, Rousseau F, Iordanova B, Glenn O., Vigneron D, Barkovich J, Studholme C. An ISO-surface folding analysis method applied to premature neonatal brain development Proc. SPIE Medical Imaging. Mar (2006). 
  27. Rousseau F, Glenn O, Iordanova B, Rodríguez-Carranza C, Vigneron D, Barkovich J, Studholme C. A novel approach to high resolution fetal brain MR imaging. Med Image Comput Comput Assist Interv. 548-555. (2005). 

Scientific Meetings – Posters and Oral Presentations 

  1. Zhao Y, Jin T, Fitz N, Yi Lu, Koldamova R, Iordanova B. “Sex-specific metabolic and vascular brain aging in preclinical models of dementia.” AAIC Toronto, Canada (July 27 – 31, 2025). 
  2. Schweitzer N, Shen Y, Zhao Y, Cover C, Alam M, Deek R, Aizenstein H, Wu M, Fitz N, Koldamova R, Vazquez A, Iordanova B. “Linking functional trajectories of cerebrovascular dysfunction to the vessel transcriptome in preclinical models of dementia.” BRAIN International Conference, Seul, South Korea, (June 1-4, 2025).  
  3. Hunter E, Iordanova B, Li J, Aizenstein H, Wu M. “Unsupervised anomaly detection in elderly brain MRI using a 3D perceptual autoencoder” OHBM Annual Conference, Brisbane, Australia, (June 24-28, 2025). 
  4. Hunter E, Zhan L, Aizenstein H, Wu M and Iordanova B. “Combining susceptibility mapping, water diffusion, and brain network measures to analyze white matter integrity in AD mouse model.” International Society for Magnetic Resonance in Medicine (ISMRM) Annual Meeting, Honolulu, Hawaii, (May 10-15, 2025). 
  5. Schweitzer N, Iordanova B, Thurston R, Lopresti B, Snitz B, Tudorascu D, Cohen A,. Aizenstein H, Wu M. “Astrocyte reactivity explains tau-related effects on hippocampal dysfunction and longitudinal atrophy in preclinical Alzheimer’s disease”. Human Amyloid Imaging (HAI) Conference, San Juan, Puerto Rico ((Jan 15-17, 2025). 
  6. Singh A, Shen Y, Schweitzer N, Vazquez A and Iordanova B. “Two-photon imaging of red blood cell velocity in small brain vessels of Alzheimer’s mice” Biomedical Engineering Society (BMES) meeting. Baltimore, MD (Oct 23-26, 2024). 
  7. Shi Z, Li J, Huang Y, Schweitzer N, Iordanova B, Ibrahim T, Yang S, Stetten G, Aizenstein H, Wu M “Exploring age-related morphological changes in cerebral arteries: a 7T TOF MRA study” OHBM Seoul, Korea (Jun 23-27, 2024). 
  8. Schweitzer N, Thurston R, Lopresti B, Klunk W, Snitz B, Iordanova B, Villemagne V, Aizenstein H, Wu M. “Exploring the interplay of plasma phosphorylated tau with GFAP, sex on hippocampal connectivity in preclinical Alzheimer’s Disease”. OHBM Seoul, Korea (Jun 23-27, 2024). 
  9. Schweitzer N, Son SJ, Fitz N, Iordanova B, Aizenstein H, Wu M “Differentially expressed proteins underpinning diabetes-driven white matter hyperintensity progression”. OHBM Seoul, Korea (Jun 23-27, 2024). 
  10. Shen Y, Schweitzer N, Cover C, Vazquez A and Iordanova B. “Red blood cell velocity in brain capillaries is associated with cerebral amyloid angiopathy load”. Optica Biophotonics Congress: Biomedical Optics, Fort Lauderdale, FL (7-10 Apr, 2024). 
  11. Hunter E, Zhan L, Zhao Y, Wu M, Aizenstein H, and Iordanova B. “Analyzing effects of cerebral microbleeds on brain connectivity in Alzheimer’s disease”. Society for Neuroscience Meeting, Washington, DC (11-15 Oct, 2023). 
  12. Shen Y, Vazquez A, Iordanova B. “Cerebral Capillary transit-time heterogeneity estimation with mesoscopic imaging”. Society for Neuroscience Meeting, Washington, DC (11-15 Oct, 2023). 
  13. Zhao Y, Jin T, Fitz N, Lu Y, Koldamova R, and Iordanova B. “Sex differences in brain creatine of Alzheimer’s disease mouse model.” Society for Neuroscience Meeting, Washington, DC (11-15 Oct, 2023). 
  14. Schweitzer N, Zhao Y, Cover C, Wu M, Aizenstein H, Vazquez A, and Iordanova B. “Cerebrovascular tortuosity as a potential early biomarker in Alzheimer’s Disease – optical and MRI study in a mouse model.” Society for Neuroscience Meeting, Washington, DC (11-15 Oct, 2023). 
  15. Zhao Y, Jin T, Fitz NF, Koldamova R, and Iordanova B. “Sex differences in the brain phosphagen energy system in Alzheimer’s disease mouse model”. 31st International Symposium on Cerebral Blood Flow and Metabolism 2023 in Brisbane, Australia (12 - 15 June 2023) 
  16. Li J, Stetten G, Schweitzer N, Ibrahim T, Iordanova B, Aizenstein H, Wu M. “Vessel Mapper - a robust vessel segmentation algorithm for 3D images” Annual Meeting of the Organization for Human Brain Mapping in Montreal, Quebec, Canada (July 22 - 26, 2023) 
  17. Li J, Schweitzer N, Z Shi Z, Ibrahim T, Yang S, Iordanova B, Aizenstein H, Wu M.  “Age- and sex-related morphological changes in cerebral blood vessels: a 7T TOF MRA Study” (Alzheimer's Association International Conference in Amsterdam, Netherlands (Jul 16 – 20, 2023). 
  18. Schweitzer N, Jinghang L, Lopresti B, Klunk B, Snitz B, Tudorascu D, Cohen A, Kamboh I, Halligan E, Villemagne V, Iordanova B, Aizenstein H, Wu M. “Risk architecture for altered hippocampal connectivity in normal aging are different between men and women”. Alzheimer's Association International Conference in Amsterdam, Netherlands (Jul 16 – 20, 2023).  
  19. Hunter E, Foley L, Zhao Y, Aizenstein H, Wu M, Iordanova B. “Examining T2* relaxometry in diffusion tensor space to quantify cerebral microbleeds in Alzheimer’s disease mouse model”. International Society for Magnetic Resonance in Medicine 23rd Meeting in Toronto, Canada (June 3 - 8, 2023) 
  20. Zhao Y, Jin T, Fitz NF, Koldamova R, and Iordanova B. “Sex-specific decoupling of cerebral blood flow and glucose metabolism in Alzheimer’s disease mouse model”. Alzheimer's Association International Conference in San Diego, CA (Jul 31 – Aug 4, 2022).  
  21. Schweitzer N, Vazquez AL, Wu M, Aizenstein H, and Iordanova B. “Age and sex-specific neurovascular dysfunctions in Alzheimer’s disease mouse model”. Alzheimer’s Disease & Related Disorders Meeting, (June 16, 2022)  
  22. Schweitzer N, Vazquez AL, Wu M, Aizenstein H, and Iordanova B. “Neurovascular dysfunctions in mouse models of Alzheimer’s Disease”. Psychiatry Research Day (June 9, 2022) 
  23. Schweitzer N, Cover C, Wu M, Aizenstein H, Vazquez A, and Iordanova B. “Sex differences in vascular reactivity of APP/PS1 mouse model of Alzheimer’s disease”. The 30th BRAIN & BRAIN PET International Symposium in Glasgow, Scotland, (May 29-June 1, 2022) 
  24. Zhao Y, Jin T, Fitz NF, Koldamova R, Vazquez AL, and Iordanova B. “Sex-specific cerebral blood flow trajectories in mouse models of Alzheimer’s Disease”. Alzheimer's Association International Conference in Denver, CO (Jul 26-30, 2021). 
  25. Schweitzer N, Farhat N, Wu M, Kofler J, Berardinelli J, Ibrahim T, Iordanova B, and Aizenstein HJ. A novel method for tracking the progression of WMHs through the alignment of premortem to postmortem MRI and histopathology. Alzheimer's Imaging Consortium, (July 26-30, 2021). 
  26. Toader A, Iordanova B, Kochanek PM, Alexander H, Fukuda M, Li L, Clark R, Manole M and Vazquez A. “In vivo assessment of neuronal and metabolic activity in the cortex after pediatric cardiac arrest”. Pediatric Academic Societies Meeting Philadelphia, PA (April 29-May 6th, 2020).  
  27. Fukuda M, Poplawsky A, Iordanova B, Vazquez AL and Kim SG. “Contributions of GABAergic neurons to neurovascular coupling in the olfactory bulb”. 42nd Annual Meeting of the Japan Neuroscience Society in Niigata, Japan (July 25-28, 2019). 
  28. Iordanova B, Fukuda M, Klunk W and Vazquez AL. “Vascular and metabolic dysfunctions in APP/PS1 mouse model of Alzheimer’s Disease” The 29th International Symposium on Cerebral Blood Flow, Metabolism and Function in Yokohama, Japan (July 4-7, 2019). 
  29. Fukuda M, Poplawsky A, Iordanova B, Vazquez AL; Kim SG. “Coupling of neuronal activity to blood flow in dendrodendritic synapses is mediated by postsynaptic GABAergic cells in olfactory bulb” The 29th International Symposium on Cerebral Blood Flow, Metabolism and Function in Yokohama, Japan (July 4-7, 2019). 
  30. Iordanova B, Toader A, Kochanek P, Alexander H, Fukuda M, Li L, Clark R, Manole MD, Vazquez AL. “In vivo assessment of cortical neural and metabolic activity after pediatric cardiac arrest”. 15th Annual Rehabilitation Institute Research Day, Pittsburgh, PA (May 22, 2019). 
  31. Iordanova B, Klunk W, Vazques AL. “Deficiencies in cerebrovascular response and tissue oxygenation of transgenic AD mice” McGowan Institute for Regeneration Medicine annual retreat in Pittsburgh, PA (March 11-12, 2019). 
  32. Lefterov I, Letronne F, Iordanova B, Fitz NF, Wolfe C, Nam KN, Playso B, Kozai TDY, Koldamova R. “Effect of APOE lipoproteins on microglial response to intracranial infusion of Aβ - in vivo two-photon imaging and transcriptomic analysis”. Society for Neuroscience Meeting, San Diego, CA. (Nov 3-7, 2018) 
  33. Iordanova B, Poplawsky AJ, Kozai TDY, Fukuda M, Kim SG and Vazquez A. “Left-right brain connectivity - how cells drive MRI functional signals” Brain Day, University of Pittsburgh, Brain Institute, Pittsburgh, PA. (October 25, 2018). 
  34. Iordanova B, Poplawsky AJ, Fukuda H, Vazquez A. “Neurovascular control along the interhemispheric circuits”, The Royal Society meeting on Interpreting BOLD in Christ Church, Oxford, UK. (Sep 9-11, 2018). 
  35. Iordanova B, Klunk W and Vazquez A. “Hypercapnia exposes deficiencies in cerebrovascular response and tissue oxygenation of transgenic AD mice”, Alzheimer's Association International Conference in Chicago, MI (July 22-26, 2018). 
  36. Koldamova R, Lefterov I, Fitz N, Nam KN, Wolfe C, Iordanova B. “Effect of Apoe Isoform on Microglial Response to Amyloid-Beta”, Alzheimer's Association International Conference in Chicago, MI (July 22-26, 2018) 
  37. Poplawsky AJ, Fukuda H, Iordanova B, Vazquez A, Kang BM, Kim J, Suh M, Kim SG. “What layer­specific fMRI responses in the rat olfactory bulb tell us about vascular regulation, hemodynamic spread, and the role of GABA cells in neurovascular coupling”. 47th Society for Neuroscience Meeting in Washington, DC. (Nov 11-15, 2017). 
  38. Iordanova B, Vazquez AL. “In vivo NADH fluorescence imaging of double transgenic AD mice reveals chronic tissue hypoxia”. Brain Day, University of Pittsburgh, Brain Institute, Pittsburgh, PA. (October 26, 2017). 
  39. Iordanova B, “Alzheimer's Disease – Neuroimaging, Biomarkers and Beyond”, Symposium on Aging and Alzheimer's Disease: Opportunities for Therapeutic Interventions hosted by Alzheimer's Association and University of Pittsburgh in Varna, Bulgaria (October 19-20, 2017). 
  40. Iordanova B, Kochanek PM, Alexander H, Fukuda M, Li L, Clark RSB, Manole MD, Vazquez AL. “In vivo Assessment of Cortical Neural and Metabolic Activity After Pediatric Cardiac Arrest”, Brain 28th Symposium on Cerebral Blood Flow, Metabolism and Function. Berlin, Germany. (April 1-4, 2017). 
  41. Iordanova B, Kochanek PM, Alexander H, Fukuda M, Li L, Clark RSB, Manole MD , Vazquez AL. “Cortical Neural and Metabolic Activity After Pediatric Cardiac Arrest”, 15th Annual Safar Center Symposium in Pittsburgh, PA (May 22-23, 2017). 
  42. Iordanova B, Murphy MC, Klunk WE and Vazquez AL. “In vivo NADH fluorescence imaging of double transgenic Alzheimer’s Disease mice reveals chronic tissue hypoxia”. Alzheimer’s Association International Conference 2016 in Toronto, Canada (Jul 24-28, 2016). 
  43. Jin T, Iordanova B, Wang P, and Kim SG. “Chemical exchange-sensitive spin-lock MRI of glucose and deoxyglucose in brain tumors” International Society for MRI in Medicine 24th Scientific Meeting in Singapore, (7-13 May, 2016) 
  44. Jin T, Iordanova B, Wang P, and Kim SG. “Chemical Exchange-Sensitive Spin-Lock MRI of Glucose and Deoxyglucose in Brain Tumors”. PENN-CEST Translational Imaging Symposium in Philadelphia, PA (Oct 25-28, 2015). 
  45. Iordanova B, Vazquez AL, Poplawsky AJ, Kozai TD, Fukuda M, Murphy M and Kim SG. “Optogenetic control of hemodynamic response in rat somatosensory cortex - fMRI and optical study” International Society for Magnetic Resonance in Medicine 23rd Meeting in Milan, Italy. (May 10-16, 2014). 
  46. Iordanova B, Vazquez AL, Poplawsky AJ, Kozai TD, Fukuda M and Kim SG.  “Optogenetic control of neurovascular coupling along the transcallosal circuits in rat somatosensory cortex” SFN scientific meeting, San Diego, CA. (Nov 9-13, 2013). 
  47. Iordanova B, Hitchens TK, Robison C, Pusateri LK, Ahrens ET. “Mitochondrial ferritin with cytoplasmic localization as an MRI reporter in olfactory sensory neurons”. ISMRM 20th Scientific Meeting in Melbourne, Australia (5-11 May, 2012).  
  48. Iordanova B and Ahrens ET. “In vivo magnetic resonance imaging of ferritin-based reporter visualizes native neuroblast migration.” ISMRM 19th Scientific Meeting in Montréal, Québec, Canada. (7-13 May, 2011). 
  49. Iordanova B and Ahrens ET. “Chimeric ferritin as an MRI reporter gene in the mouse brain.” Gordon research conference In Vivo Magnetic Resonance in Andover, NH. (25-30 July, 2010). 
  50. Iordanova B, Robison C and Ahrens ET. “Chimeric ferritin as a reporter for MRI” ISMRM 17th Scientific Meeting in Honolulu, Hawaii, HI. (18-24 April, 2009). 
  51. Iordanova B, Robison C, Goins WF and Ahrens ET. “MRI Transverse Relaxation Rate Correlates with Number of Viral Particles Expressing H-Ferritin in the CNS.” ISMRM 16th Scientific Meeting in Toronto, Ontario, Canada. (3-9 May, 2008). 
  52. Iordanova B, Robison C, Goins WF and Ahrens ET. “HSV vector mediated expression of novel MRI reporters. 11th Annual Meeting of the American Society of Gene Therapy in Boston, MA. (May 28-June 1, 2008). 
  53. Studholme C, Rodriguez-Carranza C, Cardenas V, Iordanova B, Miller S, Mukherjee P, Glenn O, Vigneron D, Barkovich A. Deformation Morphometry study of the Influences on the Pattern of Brain Tissue Development in Premature Neonates, Human Brain Mapping in Toronto, Ontario, Canada (April, 2005).