PerioMag: Resorbable dental bone regrowth-inducing membrane

Charles Sfeir, DDS, PhD Associate Professor and Chair of Periodontics
Associate Professor of Bioengineering
Associate Dean for Research, School of Dental Medicine
Director of the Center for Craniofacial Regeneration
Andrew Brown, PhD Clinical Assistant Professor of Periodontics
Program Manager, sciVelo

Bernard Costello, DMD, MD Professor of Oral and Maxillofacial Surgery
Associate Dean for Faculty Affairs

Dental implants, titanium posts inserted into the jaw bone that serve as anchors for dental prostheses, are the best method for restoring the appearance and functionality of missing teeth. 2.4 million dental implants are placed annually in the US with half of those placements requiring an additional bone grafting procedure to build a sound bony foundation for the dental implant. This process is costly (usually paid out of pocket because dental implants are considered cosmetic) and provides inconsistent outcomes. A major driver of the poor outcomes is the implantable membranes currently used to protect the regenerating bone site from chewing forces and in-growing gum tissue. These membranes currently come in resorbable and non-resorbable varieties. Resorbable membranes do not provide the mechanical strength necessary to protect the healing site from chewing forces, and non-resorbable membranes require costly and often painful surgical removal following bone healing. The PerioMag Guided Bone Regeneration (GBR) membrane is made of a metallic magnesium and polymer material specially designed to provide mechanical strength while resorbing at a safe rate, thus eliminating the painful device removal procedure. In addition, the gradual release of magnesium ions stimulates bone growth, decreasing the length of time patients need to wait to have their dental implants placed. PerioMag GBR demonstrated improved bone regeneration over currently used materials in early animal trials. The project is performing regulatory and market adoption assessments, conducting a large scale animal study, and seeking partners to investigate pathways to market.