ContegoDerm: Topical cream to prevent radiation dermatitis

Peter Wipf, PhD Scientific Co-PI
Professor of Chemistry
Co-Leader, Molecular Therapeutics Program, UPCI
(412) 624-8606
Louis D. Falo, Jr., MD, PhD Clinical Co-PI
Chairman, Department of Dermatology
Professor of Dermatology & Bioengineering
(412) 864-3760

Radiation dermatitis affects over four million cancer patients in the US. In addition to discomfort and lowering the quality of life, this disease also negatively affects cancer treatment compliance. Radiation-induced skin damage results from increased mitochondrial ROS (reactive oxygen species) and causes redness, swelling, blistering, and/or itchy skin. Currently, only symptomatic treatments exist for managing radiation dermatitis; there are no curative or preventative treatments options available to the patients. ContegoDerm is a topical cream with antioxidant properties that has been shown to significantly reduce the clinical manifestations of radiation-induced skin damage when applied either before or immediately after radiation exposure in pre-clinical studies.