ResMag: Strong and bioresorbable magnesium bone fixation

Prashant Kumta, PhD Edward R Weidlein Chair Professor
Swanson School of Engineering and School of Dental Medicine
Departments of Bioengineering, Chemical and Petroleum Engineering, Mechanical Engineering, and Materials Science and Oral Biology

Charles Sfeir, PhD Associate Dean of Research
Director, Center for Craniofacial Regeneration
School of Dental Medicine

There are currently 6 million bone fractures occurring each year within the US, of which approximately 30% require internal fixation. Bone fixation procedures primarily use permanent non-degrading metals such as titanium and stainless steel to stabilize the fracture with subsequent healing. However, these metals can cause stress-shielding, pain, interferences with future surgical procedures. Also, patients often need to undergo a secondary surgical procedure to remove these devices, further increasing patient risk and overall procedural costs. ResMag's proprietary alloy and device technologies include the development of resorbable metal screws and plates which can not only provide fracture stability during healing but also avoid the complications associated with permanent metallic devices, eliminating the need for removal surgeries, while improving the surrounding bone health. Along with the resources provided by a confirmed Optionee, the Coulter Program will help conduct animal studies to evaluate both safety and efficacy of the implant.