Neural prostheses often suffer from undesired chronic inflammatory tissue response. This can lead to neuronal loss and formation of glial scar tissue, which would serve as a barrier to neural signal transduction. In situ monitoring of neuro-inflammatory cytokines (Interleukins, TNF-Î±, MCP-1, PDGF) may improve our understanding of device induced inflammatory responses. Furthermore, early detection of the onset and degree of inflammation and releasing drugs accordingly may lead to improved long term performance of such implanted devices. For this reason, biosensors based on aptamer capture probe used in conjunction with either electrochemical or fluorescent detection have been developed. Aptamers, certain kinds of DNA or RNA molecules which can bind variety of molecules, have the overwhelming advantages over antibodies of low cost and ease of use. We have made exciting progresses and will push them closer to in vivo chronic detection.
2005 Ph.D. in Physical Chemistry, Peking University, Beijing, China
2000 B.S. in Chemistry, Peking University, Beijing, China
Postdoctoral research associate, University of Pittsburgh, Jun., 2006 - present
Postdoctoral research associate, Rice University, Oct., 2005 - May., 2006
HONORS AND AWARDS
CONFERENCES AND INVITED TALKS