About Little Lab
Who We Work With
Dr. Alan J. Russell
Highmark Distinguished Professor, Carnegie Mellon University
"Our goal is to realize the vast potential of tissue engineering and other techniques aimed at repairing damaged or diseased tissues and organs. To this end, the efforts underway in Dr. Little's lab toward regenerating tissues are of the most innovative today. We collaborate with researchers in Dr. Little's lab on projects in the areas of advanced biomaterials and biomimetic tissue engineering strategies."
Dr. Alexander Star
Associate Professor, Advanced Functional Materials, Nanosensors, Physical Organic Chemistry
"Our laboratory specializes in conjugated polymers and single-walled carbon nanotubes for their applications in nanoelectronic chemical and biological sensing. In collaboration with Little Lab researchers, efforts are underway to apply these materials to biological systems with drug delivery and therapeutic applications in completely new ways."
Dr. Angus Thomson
Ph.D., D.Sc., Distinguished Professor of Surgery
"Our laboratory collaborates heavily with Dr. Little's labs at the interface of transplant immunology and drug delivery technology. We have been testing several new technologies from Little Lab as immunosuppressive therapies. We are located directly adjacent to the BST3 facilities and provide support for surgical transplantation, lymphocyte isolation and phenotyping, and dendritic cell immunobiology."
Dr. Anna Balazs
Distinguished Professor, Department of Chemical Engineering
Robert Von der Luft Professor
"We are exploring very new ideas with the Little Lab in order to rationally design synthetic proteins that will self assemble into novel structures. Thus far, we have been able to demonstrate through theoretical and computational modeling that specific nano-scale features would lead to assembly and novel function. Researchers in the Little Lab have demonstrated that it is now possible (for the first time) to synthesize structures that have these novel features. We are very excited to see what we are able to accomplish through the combination of theoretical and experimental design."
Dr. Charles Sfeir
Associate Professor, Department of Oral Biology
Director, Center for Craniofacial Regeneration School of Dental Medicine
"Our labs, in the School of Dental Medicine, collaborate extensively with Little Lab researchers on projects related to Bone Tissue Engineering and Craniofacial Regeneration. More specifically, we are interested in several regenerative growth factors (and the rational delivery of these factors) for regeneration of bone and tooth. Through our collaborations we have discovered many new avenues of research and promising therapeutic strategies at the interface of drug delivery technology and bone biology."
Di Gao
Associate Professor, Chemical and Petroleum Engineering
"We have been working alongside researchers at Little Lab on several nanofabrication techniques that would mimic biological interactions. Our labs offer expertise in nanotechnology and nanofabrication as well as direct in-house access to the Peterson Nanofabrication Facility."
Dr. Elia Beniash
Associate Professor, Department of Oral Biology School of Dental Medicine
"Our lab specializes in Biomineralization and Bioinspired Molecular Engineering of Mineralized Tissues. Since moving to the University of Pittsburgh, we have been working with Dr. Little's lab to discover methods to heal mineralized tissue. One example of this is work toward materials called 'synthetic bone' that mimic natural properties of real bone."
Dr. Mansoor Amiji
Distinguished Professor and Chairman, Department of Pharmaceutical Sciences Northeastern University
"We have been working for years with Dr. Little on drug delivery vehicles that target tumor cells by circulation in the vasculature. Using new biomaterials synthesized in the Little Labs, we have the ability to deliver several potent chemotherapeutic agents in a triggerable manner, as well as a timed, sequential manner. Our collaborations have made significant steps toward a smart chemotherapeutic that will work far better than current clinical treatments."
Dr. Prashant Kumta
Edward R. Weidlein Chair Professor
Department of Bioengineering
Department of Chemical and Petroleum Engineering
Department of Mechanical Engineering and Material Science
Department of Oral Biology
"Our labs, along with Dr. Little's and several others, form a core research team on biomaterials for drug delivery and regenerative medicine. This group holds weekly collaborative research discussions on current projects and topics in this area. Furthermore, our labs collaborate with Little Lab on gene delivery projects using nano-sized calcium phosphates (or NanoCaPs). We have been exploring several high throughput techniques for the optimization of these gene delivery systems with a variety of biomaterial substrates."
Dr. Robert M. Enick
Bayer Professor, Department of Chemical and Petroleum Engineering
"We work with researchers in Dr. Little's labs on supercritical carbon dioxide processing of degradable materials. Supercritical CO2 fabrication techniques can bypass the use of organic solvents that can be extremely toxic to the body. By understanding thermodynamic principles behind solubility of materials in CO2, we can better understand how to implement this environmentally friendly strategy."
Dr. William Federspiel
W.K. Whiteford Professor
Departments of Bioengineering, Surgery, and Chemical Engineering
"We have been working with Little Lab to challenge fundamental understanding of how drugs are released from polymer matrices. Thus far we have been able to generate some of the most widely applicable predictive techniques to date. The combined knowledge of both of our groups has led to some ground breaking, and extremely fascinating, discoveries in the field of drug delivery."
Dr. William R. Wagner
Director, The McGowan Institute for Regenerative Medicine
Professor, Department of Surgery
Professor, Bioengineering
Professor, Chemical and Petroleum Engineering
"Our labs at the McGowan Institute for Regenerative Medicine have been working with researchers at Little Lab to create new biomaterial-based structures for the smart delivery of drugs for regenerating tissues. These devices are both stimulus responsive, and flexible, allowing for greater versatility upon implantation."