Pitt | Swanson Engineering
Sankar Profile

1178A, Benedum Hall


Link to CV


Understanding the signaling mechanisms in human embryonic stem cells can help us to improve the differentiation process. The overall goal of my project is to understand the signaling crosstalk between different growth factors that are used to differentiate the human embryonic stem cells towards definitive endoderm. I am working with PI3K, TGF-beta and Wnt pathways which are commonly modified to differentiate human embryonic stem cells towards pancreatic beta cells. High throughput analytical techniques such as Multiplex and LiCOR are employed to study the crosstalk between the different growth factors. Ongoing projects which support this goal include:

1. Dynamics of TGF beta pathway molecules during early and late endoderm differentiation

2. Crosstalk between TGF beta and PI3K/AKT pathway during endoderm differentiation


2009 PhD, Biochemistry, Central Leather Research Institute, Chennai, India.

Thesis Topic: Studies on the role of zinc induced metallothione in in regulating chromium toxicity in human lymphocytes

2000 MSc, Biochemistry, Saurastra College, Madurai, India


  • Mathew, S., Sankaramanivel, S., Mamiya, H., Banerjee, I. Systems Analysis of PI3K/AKT Pathway in Maintenance of Self-Renewal in Human Embryonic Stem Cells. In Preparation (2013).
  • Sankaramanivel, S., Mathew, S., Banerjee, I. Dynamics of PI3K and TGF-beta pathway in human embryonic stem cells towards differentiation of definitive endoderm. In Preparation (2013).
  • Sankaramanivel, S., Rajaram, A., Rajaram, R. Zinc protects human peripheral blood lymphocytes from Cr(III) toxicity. Toxicol Appl. Pharm. 2010, 243(3):405-419.
  • Vasanat, C., Sankaramanivel, S., Jana, M., Rajaram, R., Ramasami, T. Non-enzymatic phosphorylation of bovine serum albumin by Cr(V) complexes: role in Cr(VI)-induced phosphorylation and toxicity. Mol Cell Biochem. 2005 Jul; 275(1-2): 153-164.
  • Sankaramanivel, S., Jeyapriya, R., Hemalatha, D., Djody, S., Arunakaran, J., Srinivasan, N. Effect of chromium on vertebrae, femur and calvaria of adult male rats. Hum Exp Toxicol. 2006 Jun; 25(6):311-8.

Conference presentations 

  • Mathew S, Sankaramanivel S, Banerjee I. A Global Sensitivity Approach for the Analysis of Intracellular PI3K/AKT Signaling Pathway During Definitive Endoderm Induction of Human Embryonic Stem Cells.   
    • AICHE Annual Meeting, Pittsburgh, Nov, 2012, Pittsburgh, USA.
    • BMES, Oct, 2012, Atlanta, GA, USA.
  • Mathew S, Sankaramanivel S, Mamiya H, Banerjee I. Systems Analysis of the role of PI3K/AKT Pathway in the Maintenance of Self-Renewal State of Human Embryonic Stem Cells, McGowan Institute Annual Retreat, Nemacolin, PA.
  • Sankaramanivel S, Blose KJ, Philips BJ, Rubin PJ, Vorp DA. Synergistic effects of TGF-beta and uniaxial strain on differentiation of human adipose derived stem cells to smooth muscle cells.

    • McGowan Institute Annual Retreat, Mar, 2012, Nemacolin, PA

    • AHA Fellow Research Day, Feb, 2012, Pittsburgh, PA.

  • Sankaramanivel S, Blose KJ, Jeffrey K, Joseph ME, Deborah C, Rao J, Vorp, DA. Synergistic effects of chemical and mechanical stimulation towards differentiation of human pericytes to smooth muscle cells and its application, Biomechanical Day, Sep-2011, Carnegie Mellon University, Pittsburgh, PA

  • Luzo A, Sankaramanivel S, Duarte A, Andreoli M, Ribeiro T, Bordeaux-Rego P, Kharmandaya P, Boin I, Costa F, Saad S. Mesenchymal stem cells obtained from adipose tissue and umbilical cord blood and their ability to differentiate into functional hepatocytes. Mar, 2011, EASL, Berlin, Germany.