The purpose of this research is to establish a unified theory of growth and remodeling that includes contributions from the solid, fluid, and mobile species constituents of soft tissues. Towards this end our laboratory has combined theories of volumetric
growth and mixed porohyperelasticity with transport and swelling (MPHETS) to derive a new approach to modeling the growth and remodeling of biological soft tissues (GMPHETS). The developed theoretical and computational approach is flexible in that
it is capable of modeling tissue growth from stimuli in all phases - fluid, solid, and species. This will allow computational simulation of soft tissues whose extracellular matrix remodeling is influenced not only by mechanical stimuli (stretch, stress)
but also tissue fluid pressure/shear in addition to convecting and diffusing mobile species (e.g., growth factors, cytokines). The interested reader can find further detail on the theoretical and computational methods in Harper et al. 2014 and Armstrong
MH et al. 2016.