Pitt | Swanson Engineering
Mesenchymal Stem Cell-Based Therapy for Abdominal Aortic Aneurysm

Our lab, in collaboration with Dr. John Curci at Vanderbilt University, has developed a small animal model for treating an established and expanding abdominal aortic aneurysm with periadventitial delivery of adipose-derived mesenchymal stem cells. Unlike many other groups, we deliver therapeutic cells not coincident with injury but five days later, using an implantable port. Our published data show an effective halt in aneurysmal dilation following stem cell delivery, in the short term. Currently we are looking into methods to actively deliver cells into the thicker aortic wall seen in aneurysm patients.

Related Publications

1.    Blose KJ, Ennis TL, Arif B, Weinbaum JS, Curci JA, Vorp DA, “Periadventitial adipose-derived mesenchymal stem cell treatment halts elastase-induced abdominal aortic aneurysm progression”, Regenerative Medicine, 2014. Nov;9(6):733-741, PMID:25431910, PMCID: PMC4283481