Our lab has a long history of developing and utilizing novel ex-vivo vascular perfusion systems to measure biomechanical and functional properties of vascular segments under accurately simulated hemodynamic conditions. This includes the ability to assess the dynamic compliance and stiffness of veins and arteries under pulsatile pressure and flow, and bending/flexure, stretching and twisting (to simulate the coronary artery mechanical environment due to heart-induced deformations). My lab has also utilized these tools to assess the role of mechanical factors in coronary atherogenesis, intimal hyperplasia and vein graft thrombosis. We have coined the term “mechanopathobiology” to describe our approach in studying the association of mechanical factors in pathology.
1. El-Kurdi MS, Vipperman JS, Vorp DA, “Control of Circumferential Wall Stress and Luminal Shear Stress within Intact Vascular Segments Perfused Ex Vivo,” J Biomech Eng, 2008 Oct;130(5):051003-7, PMID: 19045510
2. VanEpps JS, Londono R, Nieponice A, Vorp DA, “Design and Validation of a System to Simulate Coronary Flexure Dynamics on Arterial Segments Perfused Ex Vivo,” Biomech Model Mechanobiol. 2009 Feb;8(1):57-66, PMID: 18297319 PMID: 18297319
3. VanEpps JS, Chew DW, Vorp DA, “Effects of Cyclic Flexure on Endothelial Permeability and Apoptosis in Arterial Segments Perfused Ex Vivo,” J Biomech Eng, 2009 Oct;131(10):101005, PMID: 19831475