Our lab has a versatile experimental system for the ex-vivo biomechanical and functional testing of tubular tissues. This includes our novel work on the biomechanical characterization of the urethra, colon and esophagus in health, disease and regeneration. Our urethra work includes quantification of active contractile responses due to smooth and striated muscle, alterations of urethral biomechanical function following vaginal distension (a model for stress urinary incontinence due to childbirth), or induction of diabetes mellitus or spinal cord injury. Our esophagus work included the quantification of biomechanical properties over time for an extracellular matrix-based reconstructed esophagus.
1. Prantil-Baun R, de Groat WC, Miyazato M, Chancellor MB, Yoshirmura N, Vorp DA, “Ex VivoBiomechanical, Functional, and Immunohistochemical Alterations of Adrenergic Responses in the Female Urethra in a Rat Model of Birth Trauma,” Am J Physiol Renal Physiol 2010 Aug:299(2):F316-24,
PMID: 20444739, PMCID: PMC2928526
2. Haworth DJ, Kitta T, Morelli B, Chew DW, Yoshimura N, de Groat WC, Vorp DA, “Strain-dependent urethral response”, Neurourology and Urodynamics, 2011 Nov;30(8):1652-8, PMID 21826722