Pitt | Swanson Engineering
Characterization of the Intraluminal Thrombus from Abdominal Aortic Aneurysms

A unique feature of abdominal aortic aneurysm is the presence of an intraluminal thrombus (ILT). The growth of the ILT is progressive, and presents a “Jekyll and Hyde” situation. On the one hand, the ILT provides protection for the weakened aneurysmal wall by reducing the hemodynamic stresses on the wall. On the other hand, the ILT blocks the transmission of oxygen to the wall, leaving the wall in a hypoxic state. Notably, we have identified both macrophages and collagen fibers within the ILT, reflecting that there is dynamic remodeling of the ILT - this remodeling could theoretically contribute to (and/or limit!) aneurysm growth.

Related Publications

1.    Vorp DA, Lee PC, Wang DHJ, Makaroun MS, Nemoto EM, Ogawa S, Webster MW, “Association of Intraluminal Thrombus in Abdominal Aortic Aneurysm with Local Hypoxia and Wall Weakening,” J Vasc Surg, 2001 Aug;34(2):291-99, PMID: 11496282.

2.    Wang DHJ, Makaroun MS, Webster MW, Vorp DA, “Effect of Intraluminal Thrombus on Wall Stress in Patient-Specific Models of Abdominal Aortic Aneurysm,” J Vasc Surg, 36:598-604,2002 PMID: 12218961 

3.    Rao J, Brown B, Weinbaum JS, Ofstun E, Makaroun MS, Humphrey JD, Vorp DA, “Distinct macrophage phenotype and collagen organization within the intraluminal thrombus of abdominal aortic aneurysm”, Journal of Vascular Surgery2015 Sept;62(3):585-593, PMID: 26206580, PMCID: PMC4550501