Pitt | Swanson Engineering
Wang, Yadong
Bioengineering Department, Chem/Petroleum Engineering

Postdoctoral Training in Biomedical Engineering, Massachusetts Institute of Technology, 2002

PhD in Chemistry, Stanford University, 1999

M.S. in Chemistry, Kansas State University, 1995

Polymeric biomaterials, in situ tissue engineering, drug delivery, controlled release of proteins, wound healing.

 

(2014) Elected Fellow, AIMBE.

(2013) Dutch Heart Foundation Lecture, International Symposium on Vascular Tissue Engineering, Leiden, The Netherlands.

(2012) American Heart Association Established Investigator Award.

(2012) CMU Summit New Venture Competition, 1st Place Winner (Mentor).

(2012) Randall Family Big Idea Competition, 1st Place Winner (Mentor).

(2008) Best Undergraduate Advisor Award, BMES Georgia Tech Chapter.

(2007) American Heart Association Scientist Development Award.

(2007) Best Professor Award, BMES Georgia Tech Chapter.

(2007) Hunter Chair Lecture, Clemson University.

(2007) Member, Advisory Board, Lifeboat Foundation.

(2007) SAIC Outstanding Research Paper Award.

(2005) Finalist, the INDEX: Award, Copenhagen, Denmark.

(1998) Franklin Veatch Memorial Scholarship, Stanford University.

Allen, R.A., Wu, W., Yao, M., Dutta, D., Duan, X., Bachman, T.N., Champion, H.C., Stolz, D.B., Robertson, A.M., Kim, K., Isenberg, J.S., and Wang, Y., In press, "Nerve regeneration and elastin formation with poly(glycerol sebacate)-based synthetic arterial grafts one-year post-implantation in a rat model," Biomaterials.

Awada, H., Johnson, N., and Wang, Y., In press, "Controlled Release of Vascular Endothelial Growth Factor and Hepatocyte Growth Factor Displays Strong Angiogenic Effects," Macromol. Biosci..

Bi, X., You, Z., Gao, J., Fan, X., and Wang, Y., In press, "A functional polyester carrying free hydroxyl groups promotes the mineralization of osteoblast and human mesenchymal stem cell extracellular matrix," Acta Biomater..

Rauck, B.M., Friberg, T.R., Mendez, C.A., Park, D., Shah, V., Bilonick, R.A., and Wang, Y., In press, "Biocompatible reverse thermal gel sustains the release of intravitreal bevacizumab in vivo," Invest. Ophthalmol. Vis. Sci..

Zaky, S., Tudares, M., Almarza, A., Hagandora, C., Jensen, A.D., Gao, J., Wang, Y., and Sfeir, C., In press, "Poly (glycerol sebacate) elastomer supports osteogenic phenotype for bone engineering applications," Biomed. Mater..

Deng, Y., Bi, X., Zhou, H., You, Z., Wang, Y., Gu, P., and Fan, X., 2014, "Repair of critical-sized bone defects with anti-miR-31-expressing bone marrow stromal stem cells and poly (glycerol sebacate) scaffolds," European Cells and Materials, vol.27, pp. 13-25.

Jeffries, E., and Wang, Y., 2014, "Incorporation of parallel electrospun fibers for improved topographical guidance in 3-D nerve guides," Biofabrication, vol.5, no.3.

Johnson, N., Ambre, T., and Wang, Y., 2014, "Lysine-based polycation:heparin coacervate for controlled protein delivery," Acta Biomater., vol.10, no.1, pp. 40-46.

Ritfeld, G.J., Rauck, B., Novosat, T.L., Park, D., Patel, P., Roos, R.A., Wang, Y., and Oudega, M., 2014, "The effect of a polyurethane-based reverse thermal gel on bone marrow stromal cell transplant survival and spinal cord repair," Biomaterials, vol.35, no.6, pp. 1924-1931.

Chu, H., Chen, C.W., Huard, J., and Wang, Y., 2013, "The effect of a heparin-based coacervate of fibroblast growth factor-2 on scarring in the infarcted myocardium," Biomaterials, vol.34, pp. 1747-1756.

Dutta, D., Lee, K.W., Allen, R.A., Wang, Y., Brigham, J.C., and Kim, K., 2013, "Non-invasive Assessment of Elastic Modulus of Arterial Constructs during Cell Culture using Ultrasound Elasticity Imaging," Ultrasound in Medicine and Biology, vol.39, no.11, pp. 2103-2115.

Hagandora, K., Gao, J., Wang, Y., and Almarza, A.J., 2013, "Poly (glycerol sebacate): a novel scaffold material for temporomandibular joint disc engineering.," Tissue Eng., pp. 729-737.

Johnson, N., and Wang, Y., 2013, "Controlled delivery of heparin-binding EGF-like growth factor yields fast and comprehensive wound healing," J. Control. Release, vol.166, pp. 124-129, 23154193.

Johnson, N., and Wang, Y., 2013, "Controlled delivery of Sonic hedgehog morphogen and its potential for cardiac repair," PLoS ONE, vol.8, no.5, e63075.

Lee, K.W., Johnson, N., Gao, J., and Wang, Y., 2013, "Human Progenitor Cell Recruitment via SDF-1alpha Coacervate-laden PGS Vascular Grafts," Biomaterials, vol.34, no.38, pp. 9877-9885.

Li, H., Johnson, N.R., Usas, A., Lu, A., Wang, Y., and Huard, J., 2013, "Sustained Release of BMP2 via Coacervate Improves the Osteogenic Potential of Muscle-Derived Stem Cells," Stem Cells Translational Medicine, vol.2, no.9, pp. 667-677.

Park, D., Larson, A.M., Klibanov, A.M., and Wang, Y., 2013, "Antiviral and antibacterial polyurethanes of various modalities," App. Biochem. Biotechnol., pp. 1134-1146.

Park, D., Shah, V., Rauck, B., Friberg, T.R., and Wang, Y., 2013, "An anti-angiogenic reverse thermal gel as a drug delivery system for age-related wet macular degeneration," Macromol. Biosci., vol.13, pp. 464-469.

Saparoy, A., Chen, C.W., Beckman, S., Wang, Y., and Huard, J., 2013, "The Role of Antioxidation and Immunomodulation in Stem Cell-Mediated Cardiac Repair," Int. J. Mol. Sci., vol.14, no.8, pp. 16258-16279.

Yu, J., Takanari, K., Hong, Y., Lee, K.W., Amoroso, N.J., Wang, Y., Wagner, W.R., and Kim, K., 2013, "Non-invasive Characterization of Polyurethane-based Tissue Constructs in a Rat Abdominal Repair Model Using High Frequency Ultrasound Elasticity Imaging," Biomaterials, vol.34, no.11, pp. 2701-2709.

Wang, Y., and Chu, H., 2012, "Therapeutic Angiogenesis: Controlled Delivery of Angiogenic Factors," Therapeutic Delivery, pp. 693-714.

Wang, Y., and Jeffries, E., 2012, "Biomimetic Micropatterned Multi-channel Nerve Guides by Templated Electrospinning," Biotechnol. Bioeng, pp. 1571-82.

Wang, Y., and You, Z., 2012, "A Versatile Synthetic Platform for a Wide Range of Functionalized Biomaterials," Adv. Func. Mater., vol.22, pp. 2812-20.

Wang, Y., Chu, H., and Gao, J., 2012, "Design, synthesis and biocompatibility of an arginine-based polyester."

Wang, Y., Wu, W., and Allen, R., 2012, "Fast degrading elastomer enables rapid remodeling of a cell-free synthetic graft into a neo-artery," Nature Medicine, pp. 1148-53.

Wang, Y., You, Z., and Bi, X., 2012, "Fine Control of Polyester Properties via Epoxide-opening Polymerization Using Monomers Carrying Diverse Functional Groups," . Macromol. Biosci, pp. 822-9.

Wang, Y., You, Z., Bi, X., and Fan, X., 2012, "A functional polymer designed for bone tissue engineering."

Wang, Y., You, Z., Bi, X., and Jeffries, E., 2012, "A biocompatible, metal-free catalyst and its application in microwave-assisted synthesis of functional polyesters."

Bae, H., Chu, H., Edalat, F., Cha, J.M., Sant, S., Kashyap, A., Ahari, A.F., Kwon, C.H., Nichol, J.W., Manoucheri, S., Zamanian, B., Wang, Y., and Khademhosseini, A., 2012, "Development of functional biomaterials with micro- and nanoscale technologies for tissue engineering and drug delivery applications," J Tissue Eng Regen Med., vol.6, pp. 1-14, 22711442.

Wang, Y., and Allen, R., 2011, "Rapid Self-Assembly of Tubular Arterial Media Layer from Smooth Muscle Cells in Transient Fibrin Gel."

Wang, Y., and Crapo, P., 2011, "Hydrostatic Pressure Independently Increases Elastin and Collagen Co-expression in Small-diameter Engineered Arterial Constructs," J. Biomed. Mat. Res., pp. 673-81.

Wang, Y., and Lee, K., 2011, "Elastomeric PGS Scaffolds in Arterial Tissue Engineering."

Wang, Y., Chu, H., Gao, J., Chen, C., and Huard, J., 2011, "An injectable FGF2 coacervate for persistent angiogenesis."

Wang, Y., Chu, H., Johnson, N., and Mason, N., 2011, "A [polycation:heparin] complex releases growth factors with enhanced bioactivity."

Wang, Y., Gumera, C., and Rauck, B., 2011, "Materials for Central Nervous System Regeneration: Bioactive Cues."

Wang, Y., Lee, K., and Stolz, D., 2011, "Substantial Expression of Mature Elastin in Arterial Constructs."

Wang, Y., Park, D., and Wu, W., 2011, "A functionalizable reverse thermal gel based on a polyurethane / PEG block copolymer," Biomaterials, pp. 777-86.

Wang, Y., Wilson, M., Kota, N., Kim, Y., Stolz, D., LeDuc, P., and Ozdoganlar, B., 2011, "Fabrication of Circular Microfluidic Channels by Combining Mechanical Micromilling and Soft Lithography."

Wang, Y., Wu, W., Allen, R., and Gao, J., 2011, "Artificial Niche Combining Elastomeric Substrate and Platelet Guided Vascular tissue formation of Bone Marrow Mononuclear Cells."

Wang, Y., Zerb, B., Chu, H., Osunkoya, A., and Gao, J., 2011, "A Biocompatible Arginine-based Polycation," Adv. Func. Mater., pp. 434-440.

Wang, Y., and Crapo, P., 2010, "Physiologic Compliance In Engineered Small-Diameter Arterial Constructs Based On An Elastomeric Substrate," Biomaterials, vol.31, pp. 1626-1635.

Wang, Y., Marsano, A., Maidhof, R., Wan, L., Gao, J., Tandon, N., and Vunjak-Novakovic, G., 2010, "Scaffold stiffness affects the contractile function of three dimensional engineered cardiac constructs, Biotechnol."

Wang, Y., You, Z., Cao, H., Gao, J., Shin, P., and Day, B., 2010, "A functionalizable polyester with free hydroxyl groups and tunable physiochemical and biological properties."

Wang, Y., Zern, B., and Chu, H., 2010, "Control growth factor release using a self-assembled [polycation:heparin] complex," PLoS ONE, vol.5, e11017. doi:10.1371.

Wang, Y., Lee, E., Vunjak-Novakovic, G., and Niklason, L., 2009, "A biocompatible endothelial cell delivery system for in vitro tissue engineering," Cell Transplant., pp. 731-743.

Wang, Y., Sales, V., Kim, G., Gao, J., Rusk, E., Matthews, E., Martin, D., Estrada, C., Walter, E., and Mayer, J., 2009, "Customizing Future Tissue Engineered Heart Valves Through Phenotypic Modulation of Progenitor Cells."

Wang, Y., Secasanu, V., and Giardina, C., 2009, "A novel electrospinning target for improved yield of uniaxially aligned fibers," Biotechnol. Prog., pp. 1169-1175.

Wang, Y., Gao, J., Crapo, P., and Nerem, R., 2008, "Co-Expression of Elastin and Collagen Leads to Highly Compliant Engineered Blood Vessels," J. Biomed. Mat. Res., pp. 1120-1128.

Wang, Y., Radisic, M., Marsano, A., Maidhof, R., and Vunjak-Novakovic, G., 2008, "Cardiac tissue engineering using perfusion bioreactor systems," Nat. Protoc., pp. 719-738.

Wang, Y., Radisic, M., Park, H., Salazar-Lazaro, J., Langer, R., Freed, L., and Vunjak-Novakovic, G., 2008, "Pretreatment of Synthetic Elastomer Scaffolds by Cardiac Fibroblasts Improves Engineered Heart Tissue," J. Biomed. Mat. Res., pp. 713-724.

Crapo, P., Gao, J., and Wang, Y., 2008, "Seamless Tubular Poly(glycerol sebacate) Scaffolds: High-yield Fabrication and Potential Applications. J. Biomed. Mat. Res. 86: 354-363, 2008.," J. Biomed. Mat. Res., vol.86, pp. 354-363, PMID17969024.

Wang, Y., and Gumera, C., 2007, "Modulating neuronal responses by controlled integration of acetylcholine-like functionalities in biomimetic polymers."

Wang, Y., Gao, J., Ensley, A., and Nerem, R., 2007, "Poly (glycerol sebacate) Supports the Proliferation and Phenotypic Protein Expression of Primary Baboon Vascular Cells."

Wang, Y., Kim, Y., Gao, J., and Zern, B., 2007, "Biofunctional materials for Nerve Regeneration."

Wang, Y., Salex, V., Engelmayr, G., Johnson, J., Gao, J., Sacks, M., and Mayer, J., 2007, "Protein Pre-Coating of Elastomeric Tissue-Engineering Scaffolds Increased Cellularity, Enhanced Extracellular Matrix Protein Production, and Differentially Regulated the Phenotypes of Circulating Endothelial Progenitor Cells."

Wang, Y., Bettinger, C., Weinberg, E., Borenstein, J., and Langer, R., 2006, "Three-dimensional Microfluidic Tissue Engineering Scaffolds Using a Flexible Biodegradable Polymer."

Wang, Y., Gao, J., and Crapo, P., 2006, "Macroporous Elastomeric Scaffolds with Extensive Micropores for Soft Tissue Engineering."

Wang, Y., Gao, J., Kim, Y., Coe, H., Zern, B., and Sheppard, B., 2006, "A Neuro-inductive Biodegradable Material Based on Dopamine," Proc. Natl. Acad. Sci. U.S.A., vol.103, pp. 16681-16686.

Wang, Y., Radisic, M., Park, H., Chen, F., Dennis, R., Langer, R., Freed, L., and Vunjak-Novakovic, G., 2006, "Approach to Cardiac Tissue Engineering: Oxygen Carriers and Channeled Scaffolds."

Wang, Y., Sales, V., Engelmayr, G., Gottlieb, D., Johnson, J., Gao, J., Sacks, M., and Mayer, J., 2006, "Protein Precoating of Elastomeric Tissue-Engineering Scaffolds: Extracellular Matrix Formation and Phenotypic Changes of Circulating Endothelial Progenitor Cells."

Wang, Y., Fidkowski, C., Kaazempur-Mofrad, M., Borenstein, J., Vacanti, J., and Langer, R., 2005, "Endothelialized Microvasculature Based on a Biodegradable Elastomer," Tissue Eng., pp. 302-309.

Wang, Y., Haaga, J., Exner, A., Stowe, N., and Tarcha, P., 2005, "Combined Tumor Therapy by Using Radiofrequency Ablation and 5-FU-Laden Polymer Implants: Evaluation in Rats and Rabbits."

Wang, Y., Sundback, C., Shyu, J., Faquin, W., Langer, R., Vacanti, J., and Hadlock, T., 2005, "Biocompatibility Analysis of Poly(glycerol sebacate) as a Nerve Guide Material."

Wang, Y., Langer, R., and Ijima, H., 2004, "Spheroid Formation and Expression of Liver Specific Functions of Primary Rat Hepatocytes Co-cultured with Bone Marrow Cells."

Wang, Y., Kim, Y., and Langer, R., 2003, "Degradation characteristics of Poly(glycerol sebacate)."

Wang, Y., Ameer, G., Sheppard, B., and Langer, R., 2002, "A Tough Biodegradable Elastomer."

Wang, Y., Gebbink, R., Dubois, J., Hedman, B., Hodgson, K., and Stack, T., 1999, "Capturing the Essence of a Metalloenzyme."

Wang, Y., DuBois, J., Hedman, B., Hodgson, K., and Stack, T., 1998, "Catalytic Galactose Oxidase Models: Biomimetic Cu(II)-Phenoxyl-Radical Reactivity."

Wang, Y., and Stack, T., 1996, "Galactose Oxidase Model Complexes: Catalytic Reactivities."

Zaky, S.H., Lee, K.W., Gao, J., Jensen, A., Close, J., Wang, Y., Almarza, A.J., and Sfeir, C., "Poly(glycerol sebacate) Elastomer, a Novel Material for Mechanically Loaded Bone Regeneration," Tissue Eng..

Wang, Y., 2015, "No cell seeding required: Synthetic grafts regenerate arteries in situ," Frontiers in Cardiovascular Bioengineering, Madrid, Spain.

Wang, Y., 2014, "Extending protein bioactivity with coacervates: from basic science to clinical translation," ACS National Meeting, San Francisco.

Allen, R., Noah, J., Zaky, S., Almarza, A., Sfeir, C., and Wang, Y., 2014, "Materials for tissue regeneration: Let the body do the work. (Keynote Speech)," The 9th Asian-Pacific Conference on Medical and Biological Engineering, Tainan, Taiwan.

Allen, R., Zaky, S., Almarza, A., Sfeir, C., and Wang, Y., 2014, "In Situ Tissue Engineering using Inductive Scaffolds. (Keynote Speech)," The 3rd International Symposium of Materials on Regenerative Medicine, Taoyuan, Taiwan.

Wang, Y., 2013, "Bioactive materials and constructive host remodeling," College of Material Science Engineering Seminar, Donghua University, Shanghai, China.

Wang, Y., 2013, "Biomaterials for regenerative medicine: function is the key," Department of Pharmaceutics Seminar, Gent, Belgium.

Wang, Y., 2013, "Functionalized polymers for bone regeneration," School of Medicine Seminar, Shanghai Jiaotong University, Shanghai, China.

Wang, Y., 2013, "In situ regeneration of vascular tissues: The implication for bio-transformable synthetic shunt for dialysis vascular access," Department of Internal Medicine Seminar, University of Cincinnati.

Wang, Y., 2013, "Materials for tissue regeneration: Let the body do the work," College of Life Science Seminar, Nankai University, Tianjin, China.

Wang, Y., 2013, "Materials for tissue regeneration: Let the body do the work," College of Pharmaceutical Science Seminar, Wenzhou Medical University, Wenzhou, China.

Allen, R., and Wang, Y., 2013, "Complete regeneration of arteries de novo and in situ from synthetic grafts. (Keynote Speech)," TERMIS-AP 2013 Annual Conference, Shanghai, China.

Allen, R., and Wang, Y., 2013, "Elastin production in arteries regenerated in situ from synthetic grafts," The Elastin, Elastic Fibers & Microfibrils Gordon Research Conference, Biddeford, ME.

Allen, R., and Wang, Y., 2013, "Elastomeric grafts to generate neoarteries," First International Symposium on Vascular Tissue Engineering, Leiden, The Netherlands.

Allen, R., and Wang, Y., 2013, "In situ tissue engineering: Synthetics can. (Keynote Speech)," 2013 Symposium on Biomaterials for Regenerative Medicine, Shanghai, China.

Allen, R., and Wang, Y., 2013, "The properties and form factors of polymers determine the fate of synthetic grafts in vivo," Polymers in Medicine and Biology, Santa Rosa, CA.

Allen, R., Wu, W., Yao, M., Isenberg, J., Champion, H., Robertson, A., Stolz, D., and Wang, Y., 2013, "One-Year Follow-up of Host Remodeling of Rapidly Degradable Synthetic Arterial Grafts," 2013 BMES Annual Meeting, Seattle, WA.

Allen, R.A., Wu, W., Yao, M., Dutta, D., Duan, X., Champion, H.C., Stolz, D.B., Robertson, A.M., Kim, K., Isenberg, J.S., and Wang, Y., 2013, "Long term in vivo study of rapidly degradable synthetic arterial grafts," SFB Annual Meeting, Boston, USA.

Awada, H., Johnson, N., and Wang, Y., 2013, "Coacervate-based Co-delivery of VEGF and HGF Displays Synergistic Angiogenic Effects," 2013 BMES Annual Meeting, Seattle, WA.

Chu, H., and Wang, Y., 2013, "Self assembling coacervate controls the release of heparin binding proteins: from design to in vivo functionality," 245th ACS National Meeting & Exposition, New Orleans, USA.

Gorski, J., Gao, J., Marra, K., Wang, Y., and Almarza, A., 2013, "Adipose-Derived Stem Cell Potential for Tissue Engineering the Temporomandibular Joint Disc," 2013 BMES Annual Meeting, Seattle, WA.

Hagandora, C., Lowe, J., Gao, J., Wang, Y., and Almarza, A., 2013, "The Effect of Mechanical Stimulation on TMJ Disc Regeneration," IADR/AADR/CADR General Session & Exhibition, Seattle, USA.

Johnson, N., and Wang, Y., 2013, "Accelerated re-epithelialization of skin wounds using EGF coacervate," Society for Biomaterials (SFB) Annual Meeting, Boston, MA, USA.

Johnson, N., and Wang, Y., 2013, "Controlled delivery of Sonic Hedgehog for cardiac regeneration," 2013 BMES Annual Meeting, Seattle, WA.

Johnson, N., and Wang, Y., 2013, "Extend growth factor activity to heal chronic wounds," 12th US-Japan Symposium on Drug Delivery Systems, Maui, USA.

Johnson, N., Chu, H., William, C., and Wang, Y., 2013, "A Highly Effective Growth Factor Delivery Platform," TERMIS-AP 2013 Annual Conference, Shanghai, China.

Lee, K., Johnson, N., and Wang, Y., 2013, "Progenitor Cell Recruitment via SDF-1alpha Coacervate-absorbed in Vascular Grafts," 2013 BMES Annual Meeting, Seattle, WA.

Rauck, B., Medina, C., Friberg, T., and Wang, Y., 2013, "Sustained release of bevacizumab using an injectable, degradable and biocompatible reverse thermal gel," Society for Biomaterials Annual Meeting, Boston, MA, USA.

Robertson, A.M., Duan, X., Valentin, A., Hill, M.R., Li, D., Zunino, P., Allen, R., Wang, Y., and Watkins, S., 2013, ": Modeling the Biomechanics of the Arterial Wall Across Multiple Temporal and Spatial Scales," 2014 Annual Meeting on Current Challenges in Computing Conference (CCubed) with special focus on new directions in Biomedical Research, Napa, California.

Gumera, C., Zern, B., and Wang, Y., 2013, "Biomimetic polymers and uses thereof," US 8,529,928.