Pitt | Swanson Engineering
Cui, Xinyan
Bioengineering Department
Cui, Xinyan
William Kepler Whitford Professor
Office: 5057 Bioscience Tower 3 3501 Fifth Avenue Pittsburgh, PA 15260
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PhD in Macromolecular Science and Engineering, University of Michigan, 1998-2002

MS in Biophysics, Tsinghua University, 1994-1997

BS in Polymer Materials and Chemical Engineering, Tsinghua University, 1989-1994


Conducting polymer

Implant coatings


Neural electrode tissue interface

Neural engineering

On demand drug delivery

(2013) Carnegie Science Award Emerging Female Scientist.

(2013) PKU Engineering Globex Fellow.

(2013) Visiting Professor, Taiyuan Institute of Technology.

(2008) National Science Foundation Career Award.

(2005) The Wallace Coulter Foundation Early Career Award.

(2000) Charles G. Overberger Award for Research Excellence.

(1999) Alfred P. Sloan Fellowship Award.

Alba, N.A., Du, Z.J., Catt, K.A., Kozai, T.D., and Cui, X.T., 2015, "In Vivo Electrochemical Analysis of a PEDOT/MWCNT Neural Electrode Coating.," Biosensors, no.4, pp. 618-46.

Du, Z.J., Luo, X., Weaver, C., and Cui, X.T., 2015, "Poly (3, 4-ethylenedioxythiophene)-ionic liquid coating improves neural recording and stimulation functionality of MEAs.," Journal of Materials Chemistry. C, Materials For Optical and Electronic Devices, no.25, pp. 6515-6524.

Kolarcik, C.L., Catt, K., Rost, E., Albrecht, I.N., Bourbeau, D., Du, Z., Kozai, T.D., Luo, X., Weber, D.J., and Cui, X.T., 2015, "Evaluation of poly(3,4-ethylenedioxythiophene)/carbon nanotube neural electrode coatings for stimulation in the dorsal root ganglion.," Journal of Neural Engineering, no.1, p. 016008.

Kolarcik, C.L., Luebben, S.D., Sapp, S.A., Hanner, J., Snyder, N., Kozai, T.D., Chang, E., Nabity, J.A., Nabity, S.T., Lagenaur, C.F., and Cui, X.T., 2015, "Elastomeric and soft conducting microwires for implantable neural interfaces.," Soft Matter, no.24, pp. 4847-61.

Kozai, T., Catt, K., Du, Z., Kyounghwan, N., Srivannavit, O., Haque, R.U., Seymour, J., Wise, K., Yoon, E., and Cui, X., 2015, "Chronic in vivo evaluation of PEDOT/CNT for stable neural recordings.," IEEE Transactions on Bio-medical Engineering.

Kozai, T.D., Catt, K., Li, X., Gugel, Z.V., Olafsson, V.T., Vazquez, A.L., and Cui, X.T., 2015, "Mechanical failure modes of chronically implanted planar silicon-based neural probes for laminar recording.," Biomaterials, pp. 25-39.

Kozai, T.D., Du, Z., Gugel, Z.V., Smith, M.A., Chase, S.M., Bodily, L.M., Caparosa, E.M., Friedlander, R.M., and Cui, X.T., 2015, "Comprehensive chronic laminar single-unit, multi-unit, and local field potential recording performance with planar single shank electrode arrays.," Journal of Neuroscience Methods, pp. 15-40.

Kozai, T.D., Eles, J.R., Vazquez, A.L., and Cui, X.T., 2015, "Two-photon imaging of chronically implanted neural electrodes: Sealing methods and new insights.," Journal of Neuroscience Methods.

Kozai, T.D., Jaquins-Gerstl, A.S., Vazquez, A.L., Michael, A.C., and Cui, X.T., 2015, "Brain tissue responses to neural implants impact signal sensitivity and intervention strategies.," ACS Chemical Neuroscience, no.1, pp. 48-67.

Weaver, C.L., and Cui, X.T., 2015, "Directed Neural Stem Cell Differentiation with a Functionalized Graphene Oxide Nanocomposite.," Advanced Healthcare Materials, no.9, pp. 1408-16.

Kozai, T.D., Gugel, Z., Li, X., Gilgunn, P.J., Khilwani, R., Ozdoganlar, O.B., Fedder, G.K., Weber, D.J., and Cui, X.T., 2014, "Chronic tissue response to carboxymethyl cellulose based dissolvable insertion needle for ultra-small neural probes.," Biomaterials, no.34, pp. 9255-68.

Kozai, T.D., Li, X., Bodily, L.M., Caparosa, E.M., Zenonos, G.A., Carlisle, D.L., Friedlander, R.M., and Cui, X.T., 2014, "Effects of caspase-1 knockout on chronic neural recording quality and longevity: insight into cellular and molecular mechanisms of the reactive tissue response.," Biomaterials, no.36, pp. 9620-34.

Wang, W., Xu, G., Cui, X.T., Sheng, G., and Luo, X., 2014, "Enhanced catalytic and dopamine sensing properties of electrochemically reduced conducting polymer nanocomposite doped with pure graphene oxide.," Biosensors & Bioelectronics, pp. 153-6.

Weaver, C.L., LaRosa, J.M., Luo, X., and Cui, X.T., 2014, "Electrically controlled drug delivery from graphene oxide nanocomposite films.," ACS Nano, no.2, pp. 1834-43.

Weaver, C.L., Larosa, M., Luo, X., and Cui, X., 2014, "Electrically controlled drug delivery from graphene oxide nanocomposite films," ACS Nano, no.2, pp. 1834-1843.

Huang, J., Lee, I., Luo, X., Cui, X.T., and Yun, M., 2013, "Shadow masking for nanomaterial-based biosensors incorporated with a microfluidic device.," Biomedical Microdevices, no.3, pp. 531-7.

Luo, X.L., Weaver, C.L., Tan, S.S., and Cui, X., 2013, "Pure graphene oxide doped conducting polymer nanocomposite for bio-interfacing," Journal of Materials Chemistry B, no.9, pp. 1340-1348.

Wang, J.Y., Liou, A.K., Ren, Z.H., Zhang, L., Brown, B.N., Cui, X., Badylak, S.F., Cai, Y.N., Guan, Y.Q., Leak, R.K., Chen, J., Ji, X., and Chen, L., 2013, "Neurorestorative effect of urinary bladder matrix-mediated neural stem cell transplantation following traumatic brain injury in rats.," CNS & neurological disorders drug targets, no.3, pp. 413-425.

Wang, J.Y., Liou, A.K., Ren, Z.H., Zhang, L., Brown, B.N., Cui, X.T., Badylak, S.F., Cai, Y.N., Guan, Y.Q., Leak, R.K., Chen, J., Ji, X., and Chen, L., 2013, "Neurorestorative effect of urinary bladder matrix-mediated neural stem cell transplantation following traumatic brain injury in rats.," CNS & Neurological Disorders Drug Targets, no.3, pp. 413-25.

Xu, G.Y., Li, B.B., Cui, X., Ling, L.Y., and Luo, X.L., 2013, "Electrodeposited conducting polymer PEDOT doped with pure carbon nanotubes for the detection of dopamine in the presence of ascorbic acid," Sensors and Actuators B-Chemical, pp. 405-410.

Zhang, L., Zhang, F., Weng, Z., Brown, B.N., Yan, H., Ma, X.M., Vosler, P.S., Badylak, S.F., Dixon, C.E., Cui, X.T., and Chen, J., 2013, "Effect of an inductive hydrogel composed of urinary bladder matrix upon functional recovery following traumatic brain injury.," Tissue Engineering. Part A, no.17-18, pp. 1909-18.

Kolarcik, C.L., Bourbeau, D., Azemi, E., Rost, E., Zhang, L., Lagenaur, C.F., Weber, D.J., and Cui, X.T., 2012, "In vivo effects of L1 coating on inflammation and neuronal health at the electrode-tissue interface in rat spinal cord and dorsal root ganglion.," Acta Biomaterialia, no.10, pp. 3561-75.

Kozai, T.D., Vazquez, A.L., Weaver, C.L., Kim, S.G., and Cui, X.T., 2012, "In vivo two-photon microscopy reveals immediate microglial reaction to implantation of microelectrode through extension of processes.," Journal of Neural Engineering, no.6, p. 066001.

Lee, I., Luo, X., Huang, J., Cui, X.T., and Yun, M., 2012, "Detection of cardiac biomarkers using single polyaniline nanowire-based conductometric biosensors.," Biosensors, no.2, pp. 205-20.

Azemi, E., Lagenaur, C.F., and Cui, X.T., 2011, "The surface immobilization of the neural adhesion molecule L1 on neural probes and its effect on neuronal density and gliosis at the probe/tissue interface.," Biomaterials, no.3, pp. 681-92.

Collinger, J.L., Dicianno, B.E., Weber, D.J., Cui, X.T., Wang, W., Brienza, D.M., and Boninger, M.L., 2011, "Integrating rehabilitation engineering technology with biologics.," PM & R : The Journal of Injury, Function, and Rehabilitation, no.6 Suppl 1, S148-57.

Huang, J., Luo, X., Lee, I., Hu, Y., Cui, X.T., and Yun, M., 2011, "Rapid real-time electrical detection of proteins using single conducting polymer nanowire-based microfluidic aptasensor.," Biosensors & Bioelectronics, no.1, pp. 306-9.

Justin, G.A., Zhang, Y., Cui, X.T., Bradberry, C.W., Sun, M., and Sclabassi, R.J., 2011, "A metabolic biofuel cell: conversion of human leukocyte metabolic activity to electrical currents.," Journal of Biological Engineering, p. 5.

Lee, I., Luo, X., Cui, X.T., and Yun, M., 2011, "Highly sensitive single polyaniline nanowire biosensor for the detection of immunoglobulin G and myoglobin.," Biosensors & Bioelectronics, no.7, pp. 3297-302.

Luo, X., and Cui, X.T., 2011, "Electrochemical deposition of conducting polymer coatings on magnesium surfaces in ionic liquid.," Acta Biomaterialia, no.1, pp. 441-6.

Luo, X., Lee, I., Huang, J., Yun, M., and Cui, X.T., 2011, "Ultrasensitive protein detection using an aptamer-functionalized single polyaniline nanowire.," Chemical Communications (Cambridge, England), no.22, pp. 6368-70.

Luo, X., Matranga, C., Tan, S., Alba, N., and Cui, X.T., 2011, "Carbon nanotube nanoreservior for controlled release of anti-inflammatory dexamethasone.," Biomaterials, no.26, pp. 6316-23.

Luo, X., Weaver, C.L., Zhou, D.D., Greenberg, R., and Cui, X.T., 2011, "Highly stable carbon nanotube doped poly(3,4-ethylenedioxythiophene) for chronic neural stimulation.," Biomaterials, no.24, pp. 5551-7.

Stauffer, W.R., Lau, P.M., Bi, G.Q., and Cui, X.T., 2011, "Rapid modulation of local neural activity by controlled drug release from polymer-coated recording microelectrodes.," Journal of Neural Engineering, no.4, p. 044001.

Alba, N.A., Sclabassi, R.J., Sun, M., and Cui, X.T., 2010, "Novel hydrogel-based preparation-free EEG electrode.," IEEE Transactions on Neural Systems and Rehabilitation Engineering : A Publication of The IEEE Engineering in Medicine and Biology Society, no.4, pp. 415-23.

Azemi, E., Gobbel, G.T., and Cui, X.T., 2010, "Seeding neural progenitor cells on silicon-based neural probes.," Journal of Neurosurgery, no.3, pp. 673-81.

Zhang, L., Stauffer, W.R., Jane, E.P., Sammak, P.J., and Cui, X.T., 2010, "Enhanced differentiation of embryonic and neural stem cells to neuronal fates on laminin peptides doped polypyrrole.," Macromolecular Bioscience, no.12, pp. 1456-64.

Zhou, D.D., Cui, X., Hinesa, A., and Greenberga, R.J., 2010, "Conducting Polymers in Neural Stimulation Applications," in Implantable Neural Prostheses: Techniques and Applications in the Biological and Medical Physics - Biomedical Engineering Series, ISBN 978-0-387-98119-2 e-ISBN 978-0-387-98120-8, Springer Dordrecht Heidelberg, London New York.

Luo, X., and Cui, X.T., 2009, "Sponge-like nanostructured conducting polymers for electrically controlled drug release.," Electrochemistry Communications, no.10, p. 1956.

Azemi, E., Stauffer, W.R., Gostock, M.S., Lagenaur, C.F., and Cui, X.T., 2008, "Surface immobilization of neural adhesion molecule L1 for improving the biocompatibility of chronic neural probes: In vitro characterization.," Acta Biomaterialia, no.5, pp. 1208-17.

Brayfield, C.A., Marra, K.G., Leonard, J.P., Tracy Cui, X., and Gerlach, J.C., 2008, "Excimer laser channel creation in polyethersulfone hollow fibers for compartmentalized in vitro neuronal cell culture scaffolds.," Acta Biomaterialia, no.2, pp. 244-55.

Liao, W., Randall, B.A., Alba, N.A., and Cui, X.T., 2008, "Conducting polymer-based impedimetric aptamer biosensor for in situ detection.," Analytical and Bioanalytical Chemistry, no.5, pp. 861-4.

Cui, X.T., and Zhou, D.D., 2007, "Poly (3,4-ethylenedioxythiophene) for chronic neural stimulation.," IEEE Transactions on Neural Systems and Rehabilitation Engineering : A Publication of The IEEE Engineering in Medicine and Biology Society, no.4, pp. 502-8.

Liao, W., and Cui, X.T., 2007, "Reagentless aptamer based impedance biosensor for monitoring a neuro-inflammatory cytokine PDGF.," Biosensors & Bioelectronics, no.2, pp. 218-24.

Widge, A.S., Jeffries-El, M., Cui, X., Lagenaur, C.F., and Matsuoka, Y., 2007, "Self-assembled monolayers of polythiophene conductive polymers improve biocompatibility and electrical impedance of neural electrodes.," Biosensors & Bioelectronics, no.8, pp. 1723-32.

Schwartz, A.B., Cui, X.T., Weber, D.J., and Moran, D.W., 2006, "Brain-controlled interfaces: movement restoration with neural prosthetics.," Neuron, no.1, pp. 205-20.

Stauffer, W.R., and Cui, X.T., 2006, "Polypyrrole doped with 2 peptide sequences from laminin.," Biomaterials, no.11, pp. 2405-13.

Wadhwa, R., Lagenaur, C.F., and Cui, X.T., 2006, "Electrochemically controlled release of dexamethasone from conducting polymer polypyrrole coated electrode.," Journal of Controlled Release : Official Journal of The Controlled Release Society, no.3, pp. 531-41.

Xiao, Y., Martin, D.C., Cui, X., and Shenai, M., 2006, "Surface modification of neural probes with conducting polymer poly(hydroxymethylated-3,4- ethylenedioxythiophene) and its biocompatibility.," Applied Biochemistry and Biotechnology, no.2, pp. 117-30.

Cui, X., Wiler, J., Dzaman, M., Altschuler, R.A., and Martin, D.C., 2003, "In vivo studies of polypyrrole/peptide coated neural probes.," Biomaterials, no.5, pp. 777-87.

Cui, X., Lee, V.A., Raphael, Y., Wiler, J.A., Hetke, J.F., Anderson, D.J., and Martin, D.C., 2001, "Surface modification of neural recording electrodes with conducting polymer/biomolecule blends.," Journal of Biomedical Materials Research, no.2, pp. 261-72.