Pitt | Swanson Engineering
Federspiel, William
Bioengineering Department
Federspiel, William
Faculty
Professor
Office: 302E Benedum Hall
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Research Interests: Artificial lung, cardiovascular devices, biotransport, tissue engineering.

Ph.D. in Chemical Engineering, University of Rochester, 1983

M.S. in Chemical Engineering, University of Rochester, 1980

B.S. in Chemical Engineering, University of Rochester, 1978

Advanced application of fluid mechanics and mass transport principles

combining microfabrication and fiber technology with cellular and biomolecular components to create biohybrid artificial alveolar capillary units and bioactive hollow fibers with improved gas exchange efficiency and capacity

Design and development of membrane and particle based blood purification devices for the selective or semi-selective and patterned removal of pathogenic antibodies, inflammatory mediators, and other blood borne solutes

Design and development of novel artificial lung devices for near term clinical use in the treatment of respiratory failure in patients with acute or acute on chronic lung insufficiencies

Developing improved transport models and understanding of polymer degradation and drug delivery from nanoparticles and microparticles

Development of mathematical and computer simulation models related to respiratory and cardiovascular fluid mechanics and mass transport

Development of oxygen depletion devices for blood storage systems that will extend the shelf life of red cell units and deliver red cells of higher efficacy and lower toxicity for transfusion therapy

Modeling and optimizing artificial lungs and other membrane-based medical devices where functional performance depends on underlying transport or separation principles that dictate the device characteristics

respiratory support catheters and paracorporeal assist lungs

(2014) Appointed to Honorary Editorial Board: Advanced Health Care Technologies.

(2014) ALung's Hemolung Respiratory Assist System (RAS) Recipient of Gold Award at Medical Design Excellence Awards.

(2014) 2014 Carnegie Science Awards: Honorable Mention in the Start-Up Entrepreneur Award category.

(2013) Appointed to Editorial Board: Medical Instrumentation Journal.

(2011) Member, American Institute for Medical Biological Engineering (AIMBE), Advocacy Committee.

(2011) Pitt Chronicle, featured in "Spotlight on Research: Charting the Future Through Bioengineering-Innovative ideas for lung disease and sepsis".

(2011) Regular Member, Department of Veterans Affairs: Rehabilitation Research and Development Service.

(2010) Top Ten MedGadget Award 2010: Alung's Hemolung Device.

(2010) Morning Journal, featured in "Emerging Technology May Help Patients Avoid Ventilators and Their Complications. Presented at: Morning Journal".

(2009) Chair, Graduate Committee, Department of Bioengineering, University of Pittsburgh.

(2009) Regular Member, NIH Study Section: Bioengineering, Technology and Surgical Sciences Study Section (BTSS).

(2008) Appointed to Honorary Editorial Board: Medical Devices: Evidence and Research.

(2008) Chair, NIH Special Emphasis Review panel: Bioengineering Research Applications; Respiratory Sciences.

(2008) Ad Hoc Member, NIH Study Section: Surgical Sciences, Biomedical Imaging and Bioengineering Integrated Review Group.

(2008) Appointed Member, International Scientific Advisory Committee for Biomed 2009.

(2007) Ad Hoc Member, NIH Study Section: Surgical Sciences, Biomedical Imaging and Bioengineering Integrated Review Group.

(2007) New Scientist, featured in "A slimming treatment for artificial lungs".

(2007) Elected Fellow, Biomedical Engineering Society (BMES).

(2007) Appointed to Editorial Board, Organogenesis.

(2006) Member, NIH Special Emphasis Panel: Kidney Dialysis, Monitoring and Therapeutics.

(2006) Board of Visitors Award, School of Engineering, University Of Pittsburgh.

(2006) Member, NIH Special Emphasis Panel: BRP: Respiratory.

(2006) Member, NIH Special Emphasis Panel: Bioengineering Research Applications: Respiratory.

(2006) Member, NIH Special Emphasis Panel: T1 Bioengineering Training Grants.

(2005) Appointed as William Kepler Whiteford Professor.

(2005) Member, NIH Special Emphasis Review Panel: Bioengineering Research Applications: Respiratory Sciences.

(2005) Ad Hoc Member, NIH Study Section, Vascular Cell and Molecular Biology.

(2005) IEEE Spectrum, Profiled in story: "The Body Shops".

(2004) Ad Hoc Member, NIH Study Section, Vascular Cell and Molecular Biology.

(2004) Appointed Section Editor, Bioengineering, ASAIO Journal.

(2003) Ad Hoc Member, NIH Study Section, Experimental Cardiovascular Services.

(2003) Awarded CNG Faculty Fellowship, University of Pittsburgh.

(2003) World Technology Award for Health & Medicine, nominated.

(2002) Discover Magazine, featured in "100 top science stories of 2000".

(2002) Invited Speaker: Pittsburgh Leadership Conference.

(2002) Chemical and Engineering News, Profiled in story: "Pittsburgh Rising".

(2002) Ad Hoc Member, NIH Study Section, Experimental Cardiovacular Sciences.

(2001) New Scientist, featured in "Take a Breather".

(2001) USA Today, featured in "Artificial lung device holds breath of hope".

(2001) Ad Hoc Member, NIH Study Section, Surgery and Bioengineering.

(2001) Unrestricted Research Gift from Mallinckrodt Inc.: $25,000.

(2000) Ad Hoc Member, NIH Study Section, Lung Biology and Pathology.

(1999) Ad Hoc Member, NIH Study Section, Surgery and Bioengineering.

(1999) Elected Fellow, American Institute for Medical and Biological Engineering.

(1999) Ad Hoc Member, NIH Study Section, Experimental Cardiovascular Sciences.

(1998) Ad Hoc Member, NIH Study Section, Surgery and Bioengineering.

(1989) NIH Special Study Section Site Visit Team, RR01243, University of Washington.

(1986) NIH New Investigator Research Award.

(1979) NIH National Research Service Award.

(1978) Shell Fellowship Award.

(1974) Rochester Engineering Scholarship.

Jeffries, R.G., Frankowski, B.J., Burgreen, G.W., and Federspiel, W.J., 2014, "Effect of Impeller Design and Spacing on Gas Exchange in a Percutaneous Respiratory Assist Catheter.," Artificial Organs, 24749994.

Federspiel, W.J., Maul, T., and Cook, K., In press, "Artificial Lung Chapter," in 4th Edition of the Biomedical Engineering Handbook, CRC PRESS.

Cove, M.E., and Federspiel, W.J., "Veno-venous extracorporeal CO2 removal for the treatment of severe respiratory acidosis," To appear in Critical Care.

Ye, S., Arazawa, D., Zhu, Y., Shankarraman, V., Malkin, A., Kimmel, J., Gamble, L., Ishihara, K., Federspiel, W.J., and Wagner, W.R., "Hollow Fiber Membrane Modification with Functional Zwitterionic Macromolecules for Improved Thromboresistance in Artificial Lungs," Langmuir, Manuscript submitted for publication.

Jeffries, R.G., Mussin, Y., Bulanin, D.S., Lund, L.W., Kocyildirim, E., Zhumadilov, Z.Z., Olzhayev, F.S., Federspiel, W.J., and Wearden, P.D., 2014, "Pre-clinical evaluation of an adult extracorporeal carbon dioxide removal system with active mixing for pediatric respiratory support," International Journal of Artificial Organs.

Peng, Z.Y., Bishop, J.V., Wen, X.Y., Elder, M.M., Zhou, F., Chuasuwan, A., Carter, M.J., Devlin, J.E., Kaynar, A.M., Singbartl, K., Pike, F., Parker, R.S., Clermont, G., Federspiel, W.J., and Kellum, J.A., 2014, "Modulation of chemokine gradients by apheresis redirects leukocyte trafficking to different compartments during sepsis, studies in a rat model.," Critical Care (London, England), vol.18, no.4, R141, 24992991.

Kimmel, J.D., Arazawa, D.T., Ye, S.H., Shankarraman, V., Wagner, W.R., and Federspiel, W.J., 2013, "Carbonic anhydrase immobilized on hollow fiber membranes using glutaraldehyde activated chitosan for artificial lung applications," J Mater Sci Mater Med, vol.24, no.11, pp. 2611-21, 23888352.

Lund, L.W., and Federspiel, W.J., 2013, "Removing extra CO2 in COPD patients," Current Respiratory Care Reports.

Rimmele, T., Kaynar, A.M., McLaughlin, J.N., Bishop, J., Fedorchak, M., Chuasuwan, A., Peng, Z., Singbartl, K., Frederick, D.R., Zhu, L., Carter, M., Federspiel, W.J., Zeevi, A., and Kellum, J.A., 2013, "Leukocyte capture and modulation of cell-mediated immunity during human sepsis: an ex vivo study.," Critical care (London, England), vol.17, no.2, R59, 23531333.

Alikhani, A., and Federspiel, W.J., 2012, "Selective capture of anti-A antibodies from human blood using a novel integrated bead and hollow fiber module.," Journal of biomedical materials research. Part B, Applied biomaterials, vol.100, no.8, pp. 2114-21, 22987735.

Arazawa, D.T., Oh, H.I., Ye, S.H., Johnson CA, J.R., Woolley, J.R., Wagner, W.R., and Federspiel, W.J., 2012, "Immobilized Carbonic Anhydrase on Hollow Fiber Membranes Accelerates CO(2) Removal from Blood.," Journal of membrane science, vol.404, pp. 25-31, 22962517.

Cove, M.E., Maclaren, G., Federspiel, W.J., and Kellum, J.A., 2012, "Bench to bedside review: Extracorporeal carbon dioxide removal, past present and future.," Critical care (London, England), vol.16, no.5, p. 232, 23014710.

Fisher, J., DiLeo, M., and Federspiel, W.J., 2012, "Investigating Cytokine Binding Using a Previously Reported TNF-Specific Aptamer," Open Journal of Applied Sciences, vol.2, no.3, pp. 135-138.

Namas, R.A., Namas, R., Lagoa, C., Barclay, D., Mi, Q., Zamora, R., Peng, Z., Wen, X., Fedorchak, M.V., Valenti, I.E., Federspiel, W.J., Kellum, J.A., and Vodovotz, Y., 2012, "Hemoadsorption reprograms inflammation in experimental gram-negative septic peritonitis: insights from in vivo and in silico studies.," Molecular medicine, vol.18, pp. 1366-74, 22751621.

Peng, Z.Y., Wang, H.Z., Carter, M.J., Dileo, M.V., Bishop, J.V., Zhou, F.H., Wen, X.Y., Rimmelé, T., Singbartl, K., Federspiel, W.J., Clermont, G., and Kellum, J.A., 2012, "Acute removal of common sepsis mediators does not explain the effects of extracorporeal blood purification in experimental sepsis.," Kidney international, vol.81, no.4, pp. 363-9, 21918497.

Valenti, I., and Federspiel, W.J., 2012, "On Laminar Flow in Microfabricated Channels with Partial Semi-Circular Profiles," Open Journal of Applied Sciences, vol.2, no.1, pp. 28-34.

Wearden, P.D., Federspiel, W.J., Morley, S.W., Rosenberg, M., Bieniek, P.D., Lund, L.W., and Ochs, B.D., 2012, "Respiratory dialysis with an active-mixing extracorporeal carbon dioxide removal system in a chronic sheep study.," Intensive care medicine, vol.38, no.10, pp. 1705-11, 22926651.

Alikhani, A., and Federspiel, W.J., 2011, "Theoretical and experimental analysis of anti-A antibody capture in novel integrated bead and hollow fiber modules.," Annals of biomedical engineering, vol.39, no.3, pp. 953-63, 21161682.

Batchinsky, A.I., Jordan, B.S., Regn, D., Necsoiu, C., Federspiel, W.J., Morris, M.J., and Cancio, L.C., 2011, "Respiratory dialysis: reduction in dependence on mechanical ventilation by venovenous extracorporeal CO2 removal.," Critical care medicine, vol.39, no.6, pp. 1382-7, 21317644.

DiLeo, M.V., Fisher, J.D., Burton, B.M., and Federspiel, W.J., 2011, "Selective improvement of tumor necrosis factor capture in a cytokine hemoadsorption device using immobilized anti-tumor necrosis factor.," Journal of biomedical materials research. Part B, Applied biomaterials, vol.96, no.1, pp. 127-33, 21086427.

Kimmel, J.D., Harbert, E.M., Parker, R.S., and Federspiel, W.J., 2011, "Modeling competitive cytokine adsorption dynamics within hemoadsorption beads used to treat sepsis.," Journal of chromatography. A, vol.1218, no.44, pp. 8013-20, 21962329.

Kimmel, J.D., Lacko, C.S., Delude, R.L., and Federspiel, W.J., 2011, "Characterizing accelerated capture of deoligomerized TNF within hemoadsorption beads used to treat sepsis.," Journal of biomedical materials research. Part B, Applied biomaterials, vol.98, no.1, pp. 47-53, 21504054.

Pacella, H.E., Eash, H.J., and Federspiel, W.J., 2011, "Darcy Permeability of Hollow Fiber Bundles Used in Blood Oxygenation Devices.," Journal of membrane science, vol.382, no.1-2, pp. 238-242, 22927706.

DiLeo, M.V., and Federspiel, W.J., 2010, "Scaling Issues in the Article Entitled "Cytokines in Blood From Septic Patients Interact With Surface-Immobilized Heparin"," ASAIO J, vol.56, no.4, pp. 383-4, 20592525.

Gautam, S., korchagina, E.Y., Bovin, N.V., and Federspiel, W., 2010, "Specific Antibody Filter (SAF) Binding Capacity Enhancement to Remove Anti-A Antibodies for ABO-Incompatible. Transplantation," J Biomed Mater Res B Appl Biomater, vol.95, no.2, pp. 475-480, 20878917.

Kimmel, J.D., Gibson, G.A., Watkins, S.C., Kellum, J.A., and Federspiel, W.J., 2010, "IL-6 adsorption dynamics in hemoadsorption beads studied using confocal laser scanning microscopy.," Journal of biomedical materials research. Part B, Applied biomaterials, vol.92, no.2, pp. 390-6, 19904819.

Oh, H.I., Ye, S.H., Johnson CA, J.R., Woolley, J.R., Federspiel, W.J., and Wagner, W.R., 2010, "Hemocompatibility assessment of carbonic anhydrase modified hollow fiber membranes for artificial lungs.," Artificial organs, vol.34, no.5, pp. 439-42, 20633159.

Polk, A.A., Maul, T.M., McKeel, D.T., Snyder, T.A., Lehocky, C.A., Pitt, B., Stolz, D.B., Federspiel, W.J., and Wagner, W.R., 2010, "A biohybrid artificial lung prototype with active mixing of endothelialized microporous hollow fibers.," Biotechnology and Bioengineering, vol.106, no.3, pp. 490-500, 20091735.

Alikhani, A., Korchagina, E.Y., Chinarev, A.A., Bovin, N.V., and Federspiel, W.J., 2009, "High molecular weight blood group A trisaccharide-polyacrylamide glycoconjugates as synthetic blood group A antigens for anti-A antibody removal devices.," Journal of biomedical materials research. Part B, Applied biomaterials, vol.91, no.2, pp. 845-54, 19582848.

Budilarto, S.G., Frankowski, B.J., Hattler, B.G., and Federspiel, W.J., 2009, "Flow visualization study of a novel respiratory assist catheter.," Artificial organs, vol.33, no.6, pp. 411-8, 19473135.

Burgess, K.A., Hu, H.H., Wagner, W.R., and Federspiel, W.J., 2009, "Towards microfabricated biohybrid artificial lung modules for chronic respiratory support.," Biomedical microdevices, vol.11, no.1, pp. 117-27, 18696229.

DiLeo, M.V., Fisher, J.D., and Federspiel, W.J., 2009, "Experimental validation of a theoretical model of cytokine capture using a hemoadsorption device.," Annals of biomedical engineering, vol.37, no.11, pp. 2310-6, 19680812.

DiLeo, M.V., Kellum, J.A., and Federspiel, W.J., 2009, "A simple mathematical model of cytokine capture using a hemoadsorption device.," Annals of biomedical engineering, vol.37, no.1, pp. 222-9, 18949559.

Mihelc, K.M., Frankowski, B.J., Lieber, S.C., Moore, N.D., Hattler, B.G., and Federspiel, W.J., 2009, "Evaluation of a respiratory assist catheter that uses an impeller within a hollow fiber membrane bundle," ASAIO Journal, vol.55, no.6, pp. 569-74, 19779302.

Rothstein, S.N., Federspiel, W.J., and Little, S.R., 2009, "A unified mathematical model for the prediction of controlled release from surface and bulk eroding polymer matrices.," Biomaterials, vol.30, no.8, pp. 1657-64, 19101031.

Engelmayr GC, J.R., Soletti, L., Vigmostad, S.C., Budilarto, S.G., Federspiel, W.J., Chandran, K.B., Vorp, D.A., and Sacks, M.S., 2008, "A novel flex-stretch-flow bioreactor for the study of engineered heart valve tissue mechanobiology.," Annals of biomedical engineering, vol.36, no.5, pp. 700-12, 18253834.

Gautam, S., Korchagina, E.Y., Bovin, N.V., and Federspiel, W.J., 2008, "Monoclonal anti-A antibody removal by synthetic A antigen immobilized on specific antibody filters.," Biotechnology and bioengineering, vol.99, no.4, pp. 876-83, 17705231.

Rothstein, S.N., Federspiel, W., and Little, S., 2008, "A Simple model framework for the prediction of controlled release from bulk eroding polymer matrices," J. Mater. Chem, vol.18, pp. 1873-1880, 19101031.

Svitek, R.G., and Federspiel, W.J., 2008, "A mathematical model to predict CO2 removal in hollow fiber membrane oxygenators.," Annals of biomedical engineering, vol.36, no.6, pp. 992-1003, 18347984.

Federspiel, W., 2007, "Basic transport phenomena in biomedical engineering: a review," ASAIO J, vol.53, no.3, e7.

Eash, H.J., Mihelc, K.M., Frankowski, B.J., Hattler, B.G., and Federspiel, W.J., 2007, "Evaluation of fiber bundle rotation for enhancing gas exchange in a respiratory assist catheter.," ASAIO J, vol.53, no.3, pp. 368-73, 17515731.

Kaar, J.L., Oh, H.I., Russell, A.J., and Federspiel, W.J., 2007, "Towards improved artificial lungs through biocatalysis.," Biomaterials, vol.28, no.20, pp. 3131-9, 17433433.

Zinovik, I.N., and Federspiel, W.J., 2007, "Modeling of blood flow in a balloon-pulsed intravascular respiratory catheter," ASAIO J, vol.53, no.4, pp. 464-68, 17667232.

Eash, H.J., Budilarto, S.G., Hattler, B.G., and Federspiel, W.J., 2006, "Investigating the effects of random balloon pulsation on gas exchange in a respiratory assist catheter," ASAIO J, vol.52, no.2, pp. 192-5, 16557107.

Snyder, T.A., Eash, H.J., Litwak, K.N., Frankowski, B.J., Hattler, B.G., Federspiel, W.J., and Wagner, W.R., 2006, "Blood biocompatibility assessment of an intravenous gas exchange device.," Artificial organs, vol.30, no.9, pp. 657-64, 16934093.

Solovan, J.C., Oh, H.I., Alikhani, A., Gautam, S., Vlasova, K., Korchagina, E.Y., Bovin, N.V., and Federspiel, W.J., 2006, "Synthetic blood group antigens for anti-A removal device and their interaction with monoclonal anti-A IgM.," Transplant immunology, vol.16, no.3-4, pp. 245-9, 17138061.

Budilarto, S.G., Eash, H.J., Frankowski, B.J., Hattler, B.G., and Federspiel, W.J., 2005, "Flow visualization study of a pulsating respiratory assist catheter," ASAIO J, vol.51, no.6, pp. 673-80, 16340349.

Eash, H.J., Frankowski, B.J., Hattler, B.G., and Federspiel, W.J., 2005, "Evaluation of local gas exchange in a pulsating respiratory support catheter," ASAIO J, vol.51, no.2, pp. 152-7, 15839440.

Kanick, S.C., Doyle, W.J., Ghadiali, S.N., and Federspiel, W.J., 2005, "On morphometric measurement of oxygen diffusing capacity in middle ear gas exchange.," Journal of Applied Physiology (Bethesda, Md. : 1985), vol.98, no.1, pp. 114-9, 15310742.

Svitek, R.G., Frankowski, B.J., and Federspiel, W.J., 2005, "Evaluation of a pumping assist lung that uses a rotating fiber bundle," ASAIO J, vol.51, no.6, pp. 773-780, 16340367.

Federspiel, W., and Henchir, K.A., 2004, "Artificial lungs: basic principles and current applications," in Encyclopedia of Biomaterials and Biomedical Engineering, G.L. Bowlin, and G.E. Wneck, eds., Marcel Dekker, Inc, pp. 910-921, New York.

Federspiel, W., and Svitek, R.G., 2004, "Artificial lungs: current research and future directions," in Encyclopedia of Biomaterials and Biomedical Engineering, G.L. Bowlin, and G.E. Wneck, eds., Marcel Dekker, Inc, pp. 922-931, New York.

Eash, H.J., Jones, H.M., Hattler, B.G., and Federspiel, W.J., 2004, "Evaluation of plasma resistant hollow fiber membranes for artificial lungs," ASAIO J, vol.50, no.5, pp. 491-7, 15497391.

Nolan, T.D., Hattler, B.G., and Federspiel, W.J., 2004, "Development of a balloon volume sensor for pulsating balloon catheters," ASAIO J, vol.50, no.3, pp. 225-33, 15171473.

Eash, H.J., Frankowski, B.J., Litwak, K., Wagner, W.R., Hattler, B.G., and Federspiel, W.J., 2003, "Acute in vivo testing of a respiratory assist catheter: implants in calves versus sheep," ASAIO J, vol.49, no.4, pp. 370-7, 12918576.

Hattler, B.G., and Federspiel, W., 2003, "The artificial lung," in Lung Transplantation, N.R. Banner, J.M. Polak, and M. Yacoub, eds., Cambridge University Press, pp. 386-398, Cambridge.

Hout, M.S., and Federspiel, W.J., 2003, "Mathematical and experimental analyses of antibody transport in hollow-fiber-based specific antibody filters," Biotechnol Prog, vol.19, no.5, pp. 1553-61, 14524719.

Drevon, G.F., Danielmeier, K., Federspiel, W., Stolz, D.B., Wicks, D.A., Yu, P.C., and Russell, A.J., 2002, "High-activity enzyme-polyurethane coatings.," Biotechnology and bioengineering, vol.79, no.7, pp. 785-94, 12209801.

Garcia, M.Y., Hattler, B.G., and Federspiel, W.J., 2002, "Effect of vessel compliance on the in-vitro performance of a pulsating respiratory support catheter.," Journal of biomechanical engineering, vol.124, no.1, pp. 56-62, 11871606.

Ghadiali, S.N., Federspiel, W.J., Swarts, J.D., and Doyle, W.J., 2002, "Measurement of the viscoelastic compliance of the eustachian tube using a modified forced-response test.," Auris, Nasus, Larynx, vol.29, no.1, pp. 1-5, 11772482.

Ghadiali, S.N., Swarts, J.D., and Federspiel, W.J., 2002, "Model-based evaluation of eustachian tube mechanical properties using continuous pressure-flow rate data.," Annals of biomedical engineering, vol.30, no.8, pp. 1064-76, 12449767.

Hattler, B.G., and Federspiel, W., 2002, "Gas exchange in the venous system: support for the failing lung," in The Artificial Lung, R.W. Anderson, and S.N. Vaslef, eds., Landes Bioscience, pp. 133-174, Georgetown (TX).

Hattler, B.G., Lund, L.W., Golob, J., Russian, H., Lann, M.F., Merrill, T.L., Frankowski, B., and Federspiel, W.J., 2002, "A respiratory gas exchange catheter: in vitro and in vivo tests in large animals.," The Journal of thoracic and cardiovascular surgery, vol.124, no.3, pp. 520-30, 12202869.

Lai, J., Gouldstone, A., Butler, J.P., Federspiel, W.J., and Loring, S.H., 2002, "Relative motion of lung and chest wall promotes uniform pleural space thickness.," Respiratory physiology & neurobiology, vol.131, no.3, pp. 233-43, 12126924.

Lund, L.W., Hattler, B.G., and Federspiel, W., 2002, "Gas permeance measurement of hollow fiber membranes in a gas-liquid environment," AIChE J, vol.48, no.3, pp. 635-643.

Lund, L.W., Hattler, B.G., and Federspiel, W.J., 2002, "A comparative in vitro hemolysis study of a pulsating intravenous artificial lung," ASAIO J, vol.48, no.6, pp. 631-5, 12455773.

Golob, J.F., Federspiel, W., Merrill, T.L., Frankowski, B.J., Litwak, K., Russian, H., and Hattler, B.G., 2001, "Acute in vivo testing of an intravascular respiratory support catheter," ASAIO J, vol.47, no.5, pp. 432-437, 11575808.

Federspiel, W., Hout, M.S., LeJeune, K.E., Schaack, T., and Bristow, D., 2000, "Specific removal of anti-A and anti-B antibodies using modified dialysis filters," ASAIO J, vol.46, no.6, pp. 702-706.

Federspiel, W.J., Golob, J.F., Merrill, T.L., Lund, L.W., Bultman, J.A., Frankowski, B.J., Watach, M., Litwak, K., and Hattler, B.G., 2000, "Ex vivo testing of the intravenous membrane oxygenator," ASAIO J, vol.46, no.3, pp. 261-7, 10826733.

Federspiel, W.J., Hewitt, T.J., and Hattler, B.G., 2000, "Experimental evaluation of a model for oxygen exchange in a pulsating intravascular artificial lung.," Annals of biomedical engineering, vol.28, no.2, pp. 160-7, 10710187.

Hout, M.S., Hattler, B.G., and Federspiel, W.J., 2000, "Validation of a model for flow-dependent carbon dioxide exchange in artificial lungs.," Artificial organs, vol.24, no.2, pp. 114-8, 10718764.

Hattler, B.G., and Federspiel, W.J., 1999, "Progress with the development of the intravenous membrane oxygenator.," Perfusion, vol.14, no.4, pp. 311-5, 10456786.

Hewitt, H.J., Hattler, B.G., and Federspiel, W.J., 1998, "A mathematical model of gas exchange in an intravenous membrane oxygenator," Annals of Biomedical Engineering, vol.26, no.1, pp. 166-178, 10355561.

Lund, L.W., Hattler, B.G., and Federspiel, W., 1998, "Is condensation the cause of plasma leakage in microporous hollow fiber membrane oxygenators," J. Membr. Sci, vol.147, no.1, pp. 87-93.

Vorp, D.A., Wang, D.H., Webster, M.W., and Federspiel, W.J., 1998, "Effect of intraluminal thrombus thickness and bulge diameter on the oxygen diffusion in abdominal aortic aneurysm.," Journal of biomechanical engineering, vol.120, no.5, pp. 579-83, 10412434.

Federspiel, W.J., Hout, M.S., Hewitt, T.J., Lund, L.W., Heinrich, S.A., Litwak, P., Walters, F.R., Reeder, G.D., Borovetz, H.S., and Hattler, B.G., 1997, "Development of a low flow resistance intravenous oxygenator," ASAIO J, vol.43, no.5, M725-30, 9360141.

Kameneva, M.V., Borovetz, H.S., Antaki, J.F., Litwak, P., Federspiel, W.J., Kormos, R.L., and Griffith, B.P., 1997, "Effect of perfluorochemical emulsion on hemorheology and shear induced blood trauma. Possible mechanisms and future applications.," Advances in experimental medicine and biology, vol.411, pp. 383-90, 9269453.

Vorp, D.A., Wang, D.H., Webster, M.W., and Federspiel, W., 1997, "Computational analysis of the oxygen flow in abdominal aortic aneurysm: effect of intraluminal thrombus thickness and aneurysm diameter," ASME Bioengineering Division, vol.35, pp. 73-74.

Federspiel, W., Swazik, P., Borovetz, H., Reeder, G.D., and Hattler, B.G., 1996, "Temporary support of the lungs - the artificial lung," in The Transplantation and Replacement of Thoracic Organs, D.K. Cooper, L.W. Miller, and G.A. Patterson, eds., Kluwer Academic Publishers, Boston.

Federspiel, W., Williams, J.L., and Hattler, B.G., 1996, "Gas flow dynamics in hollow fiber membranes," AIChE J, vol.42, no.7, pp. 2094-2099.

Federspiel, W.J., and Hattler, B.G., 1996, "Sweep gas flowrate and CO2 exchange in artificial lungs.," Artificial organs, vol.20, no.9, pp. 1050-2, 8864027.

Federspiel, W.J., Hewitt, T., Hout, M., Walters, F., Lund, L., Sawzik, P., Reeder, G., Borovetz, H., and Hattler, B.G., 1996, "Recent progress in engineering the Pittsburgh intravenous membrane oxygenator," ASAIO J, vol.42, no.5, M435-42, 9063960.

Konishi, R., Shimizu, R., Firestone, L., Wagner, W.R., Federspiel, W.J., Konishi, H., and Hattler, B.G., 1996, "Nitric oxide prevents human platelet adhesion to fiber membranes in whole blood," ASAIO J, vol.42, no.5, M850-3, 8945004.

Lund, L.W., Federspiel, W., and Hattler, B.G., 1996, "Gas permeability of hollow fiber membranes in a gas-liquid system," J. Membr. Sci, vol.117, pp. 207-219.

Lund, L.W., Federspiel, W.J., Walters, F.R., and Hattler, B.G., 1996, "A novel method for measuring hollow fiber membrane permeability in a gas-liquid system," ASAIO J, vol.42, no.5, M446-51, 8944921.

Macha, M., Federspiel, W.J., Lund, L.W., Sawzik, P., Litwak, P., Walters, F., Reeder, G., Borovetz, H., and Hattler, B.G., 1996, "Acute in vivo studies of the Pittsburgh intravenous membrane oxygenator," ASAIO J, vol.42, no.5, M609-15, 8944953.

Vorp, D.A., Federspiel, W.J., and Webster, M.W., 1996, "Does laminated intraluminal thrombus within abdominal aortic aneurysm cause anoxia of the aortic wall?," J Vasc Surg, vol.23, no.3, pp. 540-1, 8601904.

Chammas, P., Federspiel, W., and Eisenberg, S.R., 1994, "A microcontinuum model of electrokinetic coupling in the extracellular matrix: perturbation formulation and solution," J. Coll. Int. Sci, vol.168, pp. 526-538.

Federspiel, W., and Malai, K., 1993, "Model experiments on using tracers to measure flow in microvessels," Microvasc. Res, vol.46, pp. 333-350.

Weibel, E.R., Federspiel, W.J., Fryder-Doffey, F., Hsia, C.C., König, M., Stalder-Navarro, V., and Vock, R., 1993, "Morphometric model for pulmonary diffusing capacity. I. Membrane diffusing capacity.," Respiration physiology, vol.93, no.2, pp. 125-49, 8210754.

Federspiel, W., 1992, "An analysis of effective axial diffusion in branching networks," AIChE J, vol.38, no.10, pp. 1631-1638.

Bunk, D.A., Federspiel, W.J., and Jackson, A.C., 1992, "Influence of bifurcations on forced oscillations in an airway model.," Journal of biomechanical engineering, vol.114, no.2, pp. 216-21, 1602764.

Federspiel, W., 1991, "On the trumpet model of acinar gas transport," in Advances in Biological Heat and Mass Transfer (Vol 18), J.J. McGrath, ed., ASME Bioengineering Division, pp. 39-42, New York.

Tsuda, A., Federspiel, W., Grant Jr, P.A., and Fredberg, J.J., 1991, "Axial dispersion of inert species in alveolated channels: an experimental study," Chem. Eng. Sci., vol.46, no.5/6, pp. 419-426.

Federspiel, W., 1990, "Fluid mechanics in alveolar ducts," in Biofluid Mechanics 3, C.L. Lucas, and D.J. Schneck, eds., New York University Press, pp. 21-25, New York.

Federspiel, W., 1990, "Nonclassical features of gas transport and exchange at the alveolar level," in Respiratory Biomechanics: Engineering Analysis of Structure and Function, M.A. Farrell-Epstein, and J.R. Ligas, eds., Springer Verlag, pp. 90-97, New York.

Federspiel, W.J., 1990, "Use of tracers to measure flow within single microvessels.," Microvascular research, vol.40, no.3, pp. 394-411, 2084503.

Federspiel, W.J., 1989, "Pulmonary diffusing capacity: implications of two-phase blood flow in capillaries.," Respiration physiology, vol.77, no.1, pp. 119-34, 2799105.

Federspiel, W.J., and Fredberg, J.J., 1988, "Axial dispersion in respiratory bronchioles and alveolar ducts.," Journal of applied physiology (Bethesda, Md. : 1985), vol.64, no.6, pp. 2614-21, 3403446.

Gayeski, T.E., Federspiel, W.J., and Honig, C.R., 1988, "A graphical analysis of the influence of red cell transit time, carrier-free layer thickness, and intracellular PO2 on blood-tissue O2 transport.," Advances in experimental medicine and biology, vol.222, pp. 25-35, 3364248.

Federspiel, W.J., 1986, "A model study of intracellular oxygen gradients in a myoglobin-containing skeletal muscle fiber.," Biophysical journal, vol.49, no.4, pp. 857-68, 3719069.

Federspiel, W.J., and Popel, A.S., 1986, "A theoretical analysis of the effect of the particulate nature of blood on oxygen release in capillaries.," Microvascular research, vol.32, no.2, pp. 164-89, 3762425.

Clark A, J.R., Federspiel, W.J., Clark, P.A., and Cokelet, G.R., 1985, "Oxygen delivery from red cells.," Biophysical journal, vol.47, no.2 Pt 1, pp. 171-81, 3978198.

Federspiel, W., and Cokelet, G.R., 1984, "Blood viscoelasticity for conditions of physiological flow in small arteries," Chem. Eng. Comm., vol.30, pp. 275-284.

Federspiel, W.J., 1984, "The effect of myoglobin concentration on muscle cell PO2 gradients.," Advances in experimental medicine and biology, vol.180, pp. 539-43, 6534126.

Federspiel, W.J., and Sarelius, I.H., 1984, "An examination of the contribution of red cell spacing to the uniformity of oxygen flux at the capillary wall.," Microvascular research, vol.27, no.3, pp. 273-85, 6727699.

Honig, C.R., Gayeski, T.E., Federspiel, W., Clark A, J.R., and Clark, P., 1984, "Muscle O2 gradients from hemoglobin to cytochrome: new concepts, new complexities.," Advances in experimental medicine and biology, vol.169, pp. 23-38, 6731086.

Clark Jr, A., Cokelet, G.R., and Federspiel, W., 1981, "Erythrocyte motion and oxygen transport," Biblthca. Anat., vol.20, pp. 385-388.

Federspiel, W.J., 2014, "Hollow Fiber Membrane Modification For CO2 Removal Enhancement. CO2 Removal Enhancement Coating," ASAIO 60th Annual Conference, Washington, DC.

Federspiel, W.J., 2014, "Respiratory Dialysis: The New Wave in Extracorporeal CO2 Removal," 7th World Congress of Biomechanics, Boston, MA.

Arazawa, D.T., Kimmel, J.D., and Federspiel, W.J., 2014, "Dilute Acidic Sweep Gas with Carbonic Anhydrase on Hollow Fibers Synergistically Accelerates CO2 Removal from Blood," McGowan Institute Scientific Retreat, Farmington PA.

D'Aloiso, B.D., Madhani, S.P., Frankowski, B.J., and Federspiel, W.J., 2014, "Semi-empirical model of flow resistance through PMP blood oxygenation devices," BMES Annual Meeting, San Antonio, TX.

Jeffries, R.G., Mussin, Y., Bulanin, D.S., Lund, L.W., Kocyildirim, E., Zhumadilov, Z.Z., Olzhayev, F.S., Federspiel, W.J., and Wearden, P.D., 2014, "In Vitro and Seven-Day Chronic In Vivo Evaluation of the Hemolung(r) Adult CO2 Removal System for Pediatric Respiratory Support," McGowan Institute Scientific Retreat, Farmington PA.

Madhani, S., Burgreen, G., Frankowski, B., Bermudez, C., and Federspiel, W.J., 2014, "Development of the Paracorporeal Ambulatory Assist Lung (PAAL), an Integrated Pump Lung System," BMES 2014 Annual Conference, San Antonio, TX.

Madhani, S.P., Frankowski, B., and Federspiel, W.J., 2014, "Development of a high efficiency Passive exchange Paracorporeal Ambulatory Assist Lung (P-PAAL) bundle geometry," ASAIO 60th Annual Conference, Washington DC.

Madhani, S.P., Frankowski, B., and Federspiel, W.J., 2014, "Development of a High Efficiency Passive Exchange Paracorporeal Ambulatory Assist Lung (P-PAAL) through Bundle Geometry Variation," McGowan Institute Scientific Retreat, Farmington, PA.

Malkin, A., Sun, F., Federspiel, W.J., Kellum, J.A., and Singbartl, K., 2014, "Development of an Extracorporeal Neutrophil Reprogramming Device for the Treatment of Sepsis," McGowan Institute Scientific Retreat, Farmington PA.

Federspiel, W.J., 2013, "Novel Pediatric Lung Devices In Development," ASAIO 59th Annual Conference, Chicago, IL.

Federspiel, W.J., 2013, "Respiratory Dialysis: Low Flow CO2 Removal and the Road to the Hemolung(r)," Cardiovascular Bioengineering Training Program, University of Pittsburgh.

Federspiel, W.J., 2013, "Respiratory Dialysis: Lung Support Designed for the Pulmonary Intensivist," Design of Medical Devices Conference, University of Minnesota.

Federspiel, W.J., 2013, "Respiratory Dialysis: The New Wave in Extracorporeal CO2 Removal (ECCO2R)," Biomedical Engineering Seminar, Ohio State University.

Federspiel, W.J., 2013, "Respiratory Dialysis: The New Wave in Extracorporeal CO2 Removal (ECCO2R)," Biomedical Engineering Seminar, University of Rochester.

Federspiel, W.J., 2013, "Respiratory Dialysis: The New Wave in Extracorporeal CO2 Removal," Biomedical Engineering Seminar, Carnegie Mellon University.

Federspiel, W.J., 2013, "Respiratory Lung Assist: From Hemolung To Paracorporeal Ambulatory Assist Lung (PAAL)," ASAIO 59th Annual Conference, Chicago, IL.

Arazawa, D.T., and Federspiel, W.J., 2013, "Dilute Acidic Sweep Gas with Carbonic Anhydrase on Hollow Fibers Synergistically Accelerates CO2 Removal from Blood," McGowan Institute for Regenerative Medicine Scientific Retreat, Nemacolin Woodlands Resort, PA.

Jeffries, R.G., Frankowski, B., Burgreen, G., and Federspiel, W.J., 2013, "In Vitro Hemolysis of High-Velocity Impellers for Improved Gas Transfer in Blood Oxygenators," McGowan Institute for Regenerative Medicine Scientific Retreat, Nemacolin Woodlands Resort, PA.

Jeffries, R.G., Mussin, Y., Bulanin, D.S., Lund, L.W., Zhumadilovas, Z., Federspiel, W.J., Kocyildirim, E., and Wearden, W.D., 2013, "Seven-Day In Vivo Evaluation of a Low-Flow Active-Mixing Extracorporeal Carbon Dioxide Removal System (ECCO2R) for Pediatric Respiratory Support," ASAIO 59th Annual Conference, Chicago, IL.

Malkin, A., Kimmel, J., Harbert, E., Sun, F., Singbartl, K., Federspiel, W.J., and Kellum, J., 2013, "Development of an Extracorporeal Neutrophil Reprogramming Device for the Treatment of Sepsis," McGowan Institute for Regenerative Medicine Scientific Retreat, Nemacolin Woodlands Resort, PA.

Sen, A., Kellum, J.A., and Federspiel, W.J., 2013, "Extracorporeal Carbondioxide Removal By Zero Bicarbonate Dialysate: A Novel Lung Protection Strategy."

Federspiel, W.J., 2012, "Extracorporeal CO2 Removal for Preventing Intubation in Patients With Exacerbated COPD: Results of the Hemolung Pilot Study," American Society for Artificial Internal Organs (ASAIO), San Francisco, CA.

Federspiel, W.J., 2012, "Respiratory Dialysis: The New Wave in Extracorporeal CO2 Removal," 8th International Symposium on Respiratory Disease & ATS Joint Symposium, Shanghai International Convention Center.

Arazawa, D., and Federspiel, W., 2012, "Immobilized Carbonic Anhydrase on Hollow Fibers Accelerates CO2 Removal," McGowan Institute for Regenerative Medicine Retreat.

Arazawa, D., Kimmel, J., and Federspiel, W.J., 2012, "Dilute Acidic Sweep Gas with Carbonic Anhydrase on Hollow Fibers Synergistically Accelerates CO2 Removal from Blood," BMES 2012 Annual Meeting, Atlanta, GA.

Cove, M., Sen, A., Federspiel, W.J., and Kellum, J.A., 2012, ""Respiratory Dialysis": A Novel Approach for Enabling Lung Protective Ventilation."

Harbert, E., Nichols, E., Federspiel, W.J., Kellum, K., and Singbartl, K., 2012, "Development of a Leukocyte Programming Device," BMES 2012 Annual Meeting, Atlanta, GA.

Jeffries, R.G., Frankowski, B.J., Burgreen, G., and Federspiel, W., 2012, "In Vitro Hemocompatibility of the Impeller Percutaneous Respiratory Assist Device," McGowan Institute for Regenerative Medicine Retreat.

Kimmel, J., Arazawa, D., and Federspiel, W.J., 2012, "Bioactive Hollow Fiber Membranes Coated with Chitosan and Carbonic Anhydrase for Artificial Lung Applications," BMES 2012 Annual Meeting, Atlanta, GA.

Kimmel, J.D., Arazawa, D., and Federspiel, W., 2012, "Bioactive hollow fiber membranes coated with chitosan and carbonic anhydrase for artificial lung applications," McGowan Institute for Regenerative Medicine Retreat.

Nichols, E., Singbartl, K., Kellum, J., and Federspiel, W., 2012, "Neutrophil reprogramming in an extracorporeal device using IL-8-induced receptor down-regulation," McGowan Institute for Regenerative Medicine Retreat.

Federspiel, W., 2011, "Engineering a Better Treatment for Sepsis," McGowan Institute for Regenerative Medicine Retreat.

Federspiel, W., Rojas, M., and Gilbert, T., 2011, "Regenerative Technologies for the Lung," McGowan Institute for Regenerative Medicine Retreat.

Arazawa, D., Federspiel, W., and Oh, H., 2011, "Accelerated CO2 Removal for Artificial Lung Applications," 57th Annual Conference of the American Society for Artificial Internal Organs (ASIAO), Washington D.C.

Arazawa, D., and Federspiel, W., 2011, "Immobilized Carbonic Anhydrase on Hollow Fibers Accelerates CO2 Removal from Blood," McGowan Institute for Regenerative Medicine Retreat, Pittsburgh, PA.

Jeffries, R., Frankowski, B., Burgreen, G., Shaffer, F., and Federspiel, W., 2011, "Rotating Impeller Spacing Effects in Hollow Fiber Membrane (HFM) Respiratory Assist Devices," 57th Annual Conference of the American Society for Artificial Internal Organs (ASIAO), Washington DC.

Jeffries, R.G., and Federspiel, W., 2011, "Rotating Impeller Spacing Effects in Hollow Fiber Membrane Respiratory Assist Devices," McGowan Institute for Regenerative Medicine Retreat.

Nichols, E., DiLeo, M.V., Federspiel, W., Singbartl, K., and Kellum, J., 2011, "Neutrophil reprogramming in an extracorporeal device using IL-8-induced receptor down-regulation," McGowan Institute for Regenerative Medicine Retreat.

Tengood, J., Federspiel, W., and Little, S., 2011, "Release of Angiogenic Growth Factors from Porous Hollow Fiber Membranes," McGowan Institute for Regenerative Medicine Retreat, Farmington, PA.

Vodovotz, Y., Valenti, I., Peng, Z., Namas, R., Mi, Q., Kellum, J., Federspiel, W., DiLeo, M., and Barclay, D., 2011, "Effects of Hemoadsoprtion of inflammation in e.coli induced fibrin peritontis," Society of Critical Care Medicine Annual Meeting.

Arazawa, D., Oh, H., and Federspiel, W., 2010, "Immobilized Carbonic Anhydrase on Hollow Fibers Accelerates CO2 Removal from Blood," McGowan Institute for Regenerative Medicine Retreat, Pittsburgh, PA.

Batchinsky, A., Jordan, B., Regn, D., Necsoiu, C., Federspiel, W., Morris, M., Blackbourne, L., and Cancio, L., 2010, "Veno-venous Extracoporeal CO2 Removal: Reduction in Dependence on Mechanical Ventilation via the Hemolung Respiratory Assist System," U.S. Army Institute of Surgical Research Presentation: NATO, RTO Human Factors and Medicine Panel, Essen, Germany.

Burki, N.K., Bieniek, P.D., Federspiel, W., Morley, S.W., Ochs, B.D., and Wearden, P.D., 2010, "Efficacy of Extracorporeal CO2 Removal with the Hemolung: Results in Animals."

DiLeo, M.V., and Federspiel, W., 2010, "Selective improvement of TNF capture in a cytokine hemoadsorption device using immobilized anti-TNF," McGowan Institute for Regenerative Medicine Retreat, Pittsburgh, PA.

Kimmel, J.D., DiLeo, M.V., Valenti, I.E., Gibson, G.A., Watkins, S.C., and Federspiel, W., 2010, "Dynamics of cytokine capture within hemoadsorption beads used to treat sepsis," McGowan Institute for Regenerative Medicine Retreat, Pittsburgh, PA.

Moore, N., Mihelc, K., Frankowski, B., Shaffer, F., Burgreen, W., and Federspiel, W., 2010, "A Percutaneous Respiratory Assist Catheter Using an Array of Internalized Impellers," McGowan Institute for Regenerative Medicine Retreat, Pittsburgh, PA.

Valenti, I.E., and Federspiel, W., 2010, "Effect of red blood cells on the adsorption of cytokines in a hemoadsorbtion device for the treatment of sepsis," McGowan Institute for Regenerative Medicine Retreat, Pittsburgh, PA.

Federspiel, W., 2009, "Development of a Novel Respiratory Assist Catheter," ESAO Annual Conference, Compiegne, France.

Federspiel, W., 2009, "Towards Biohybrid Microfabricated Artificial Lungs," Keynote lecturer-ESAO Annual Conference, Compiegne, France.

Federspiel, W., 2009, "Towards Improved Respiratory Assist Devices," Tulane University, New Orleans.

Batchinsky, A., Jordan, B.S., Regn, D., Necsoiu, C., Morley, S., Rosenberg, M., Federspiel, W., Hattler, B.G., Morris, M., Blackbourne, L., and Cancio, L., 2009, "Veno-venous Extracoporeal CO2 Removal: Reduction in Dependence on Mechanical Ventilation via the Hemolung Respiratory Assist System," U.S. Army Institute of Surgical Research. 75th Annual Meeting of the American College of Chest Physicians, San Diego, California.

Burgess, K., Wagner, W.R., and Federspiel, W., 2009, "Towards Biohybrid Microfabricated Artificial Lungs," European Society of Artificial Organs (ESAO) Conference, Compiegne, France.

DiLeo, M., and Federspiel, W., 2009, "Improving cytokine removal rate using anti-TNF immobilized beads within a cytoking absorption device," McGowan Institute for Regenerative Medicine Annual Retreat.

DiLeo, M., Kimmel, J., Kellum, J.A., and Federspiel, W., 2009, "Modeling Cytokine Capture in a Hemoabsorption Device for the Treatment of Sepsis," European Society of Artificial Organs (ESAO) Conference, Compiegne, France.

DiLeo, M.V., and Federspiel, W., 2009, "Selective improvement of TNF capture in a cytokines adsorption device using anti-TNF," BMES Conference, Pittsburgh, PA.

Fisher, J., DiLeo, M., and Federspiel, W., 2009, "Investigating Cytokine Removal Using TNF Specific Aptamers," McGowan Institute for Regenerative Medicine Annual Retreat.

Kimmel, J., DiLeo, M., Valenti, I., Gibson, G., Federspiel, W., and Watkins, S., 2009, "Dynamics of Cytokine Capture Within Hemoadsorption Beads Used To Treat Sepsis," McGowan Institute for Regenerative Medicine Annual Retreat.

Kimmel, J.D., DiLeo, M.V., Valenti, I.E., Gibson, G.A., Watkins, S.C., and Federspiel, W., 2009, "Dynamics of cytokine capture within hemoadsorption beads used to treat sepsis," ASME Summer Bioengineering Conference, Lake Tahoe, CA.

Kimmel, J.D., Gibson, G.A., Watkins, S.C., and Federspiel, W., 2009, "Dynamics of cytokine capture within hemoadsorption beads used to treat sepsis," BMES Conference, Pittsburgh, PA.

Mihelc, K., Frankowski, B., Lieber, S., Moore, N., Hattler, B.G., and Federspiel, W., 2009, "Development of a Novel Respiratory Assist Catheter," European Society of Artificial Organs (ESAO) Conference, Compiegne, France.

Moore, N., Mihelc, K., Frankowski, B., and Federspiel, W., 2009, "A percutaneous respiratory assist catheter using an array of internalized impellers," BMES Conference, Pittsburgh, PA.

Valenti, I.E., DiLeo, M.V., and Federspiel, W., 2009, "Effect of red blood cells on the adsorption of cytokines in a hemoadsorption device for the treatment of sepsis," BMES Conference, Pittsburgh, PA.

Federspiel, W., 2008, "Respiratory Assist Devices for Pulmonary Intensivists," ASAIO Annual Conference, San Francisco, CA.

DiLeo, M., and Federspiel, W., 2008, "Improving cytokine removal rate using anti-TNF immobilized beads within a cytokine adsorption device," Biomedical Engineering Society Annual Fall Meeting, St. Louis, MO.

Fisher, J., DiLeo, M., and Federspiel, W., 2008, "Investigating Cytokine Removal Using TNF Specific Aptamers," Biomedical Engineering Society Annual Fall Meeting, St. Louis, MO.

Fisher, J., DiLeo, M.V., and Federspiel, W., 2008, "Cytokine Removal Using a Selective Hemoadsorption Device," McGowan Institute for Regenerative Medicine Annual Retreat, Farmington, PA.

Housler, G.J., and Federspiel, W., 2008, "Antibody Removal with Polymethylpentene (PMP) Hollow Fibers by Immobilized Synthetic Antigen," McGowan Institute for Regenerative Medicine Annual Retreat, Farmington, PA.

Kellum, J., Federspiel, W., Clermont, G., DiLeo, M., Vodovotz, Y., Chang, S., Peng, Z., Kimmel, J., Daun, S., Capponi, V., and Wagner, W., 2008, "Systems Engineering of a Pheresis Intervention for Sepsis (SEPsIS)," Annual NIH BRP Grantee Meeting, Bethesda, MD.

Kimmel, J., Federspiel, W., Gibson, G., and Watkins, S., 2008, "Cytokine Hemoadsorption Dynamics using Confocal Laser Scanning Microscopy," Biomedical Engineering Society Annual Fall Meeting, St. Louis, MO.

Kimmel, J., and Federspiel, W., 2008, "Cytokine Hemoadsorption Dynamics using Confocal Laser Scanning Microscopy," ASAIO Conference, San Francisco, CA.

Kimmel, J., Gibson, G., Watkins, S., and Federspiel, W., 2008, "Cytokine Hemoadsorption Dynamics using Confocal Laser Scanning Microscopy," International Conference on Mechanics in Medicine and Biology, Pittsburgh, PA.

Kimmel, J.D., and Federspiel, W., 2008, "Cytokine Hemoadsorption Dynamics using Confocal Laser Scanning Microscopy," 7A.

Kimmel, J.D., and Federspiel, W., 2008, "Cytokine Hemoadsorption Dynamics using Confocal Laser Scanning Microscopy," McGowan Institute for Regenerative Medicine Annual Retreat, Farmington, PA.

Morley, S., Rosenberg, M., Federspiel, W., Hattler, B.G., and Batchinsky, A., 2008, "Respiratory dialysis. A new therapy for Chronic Obstructive Pulmonary Disease," 16th Winter Symposium on Intensive Care Medicine, Steamboat Springs, CO.

Morley, S., Rosenberg, M., Federspiel, W., Hattler, B.G., and Batchinsky, A., 2008, "Respiratory Dialysis. A New Therapy for Chronic Obstructive Pulmonary Disease," P303.

Rothstein, S.N., Federspiel, W., and Little, S., 2008, "A Unified Mathematical Model for Predicting Controlled Release from Surface and Bulk Eroding Matrices without Regression," AIChE 2008 Annual Meeting, Philadelphia, PA.

Rothstein, S.N., Federspiel, W., and Little, S., 2008, "Towards the Rational Design of Biodegradable Controlled Release Vehicles," AIChE 2008 Annual Meeting, Philadelphia, PA.

Rothstein, S.N., Federspiel, W., and Little, S., 2008, "Towards the Rational Design of Controlled Release Therapeutics," AIChE 2008 Annual Meeting, Philadelphia, PA.

Rothstein, S.N., Federspiel, W., and Little, S.R., 2008, "Towards the Rational Design of Controlled Release Therapeutics," Biotechnology and Bioengineering Research Symposium, Biomedical Engineering Graduate Society Symposium, Carnegie Mellon University, Pittsburgh, Pennsylvania.

Rothstein, S.N., and Federspiel, W., 2008, "Towards the rational design of controlled release therapeutics," McGowan Institute for Regenerative Medicine Annual Retreat, Farmington, PA.

Federspiel, W., 2007, "Systems Engineering of a Pheresis Intervention for Sepsis," NIH BRP, Bethesda, MD.

Federspiel, W., Oh, H.I., Kaar, J.L., and Russell, A.J., 2007, "Towards improved artificial lungs through biocatalysis," Society for Biomaterials Annual Meeting, Chicago, IL.

Federspiel, W., Rothstein, S.N., and Littler, S.R., 2007, "A New Predictive Model for Drug Release Based on Void Growth and Coalescence: A Continuum and Ensemble Approach," Society for Biomaterials Annual Meeting, Chicago, IL.

Alikhani, A., Gautam, S., and Federspiel, W., 2007, "Development of New Integrated Affinity Bead and Microfiltration Fiber Specific Antibody Filters," Biomedical Engineering Society Annual Fall Meeting, Los Angeles, CA.

DiLeo, M.V., Kellum, J.A., and Federspiel, W., 2007, "Development of a Selective Immunoadsorption Device for the Treatment of Sepsis," Biomedical Engineering Society Annual Fall Meeting, Los Angeles, CA.

DiLeo, M.V., Kellum, J.A., and Federspiel, W., 2007, "Optimization of a Hemoadsorptive Device for the Treatment of Severe Sepsis," McGowan Institute for Regenerative Medicine Annual Retreat, Farmington, PA.

Fisher, J., DiLeo, M.V., and Federspiel, W., 2007, "Cytokine Removal Using a Selective Hemoadsorption Device," Bioemdical Engineering Society Annual Fall Meeting, Los Angeles, CA.

Gautam, S., Alikhani, A., and Federspiel, W., 2007, "Specific Antibody Filter (SAF) to remove Anti-A Antibodies for ABO-Incompatible Transplantation," McGowan Institute for Regenerative Medicine Annual Retreat, Farmington, PA.

Oh, H.I., Kaar, J.L., Russell, A.J., and Federspiel, W., 2007, "Bioactive hollow fibers towards compact artificial lungs," Biomedical Engineering Society, Los Angeles, CA.

Rothstein, S.N., Federspiel, W., and Little, S.R., 2007, "A Simple Model for Predicting Controlled Release From Biodegradable Polymer Matrices," Society for Biomaterials Annual Spring Meeting, Chicago, IL.

Federspiel, W., 2006, "Supporting the failing lung: The need for new strategies," Biomedical Engineering Society Fall Meeting.

Federspiel, W., 2006, "Systems Intervention of a Pheresis Intervention for Sepsis (SEPsIS)," Sixth BRP Grantee Meeting, Bethesda, MD.

Alikhani, A., Bovin, N.V., and Federspiel, W., 2006, "Utilizing Surface Plasmon Resonance to Increase Antibody Removal of Specific Antibody Filters," Biomedical Engineering Society Annual Fall Meeting, Chicago, IL.

Ciak, E.M., Gautam, S., Alikhani, A., and Federspiel, W., 2006, "Specific Antibody Filter (SAF) for Removal of Anti-A Antibodies for ABO-Incompatible Transplantation," Biomedical Engineering Society Annual Fall Meeting, Chicago, IL.

Gautam, S., Alikhani, A., Bovin, N.V., and Federspiel, W., 2006, "Antibody Removal by Immobilized Synthetic Antigen in Specific Antibody Filters," 13A.

Oh, H.I., Kaar, J.L., Russell, A.J., and Federspiel, W., 2006, "Application of carbonic anhydrase for improved CO2 exchange in artificial lungs," Biomedical Engineering Society Annual Fall Meeting, Chicago, IL.

Oh, H.I., Kaar, J.L., Russell, A.J., and Federspiel, W., 2006, "Immobilization and assessment of carbonic anhydrase on hollow fiber membranes for enzyme-enhanced artificial lungs," 67A.

Polk, A.A., McKeel, D.T., Federspiel, W., and Wagner, W.R., 2006, "A biohybrid lung prototype with active mixing and oxygenation of endothelialized microporous hollow fibers," 67A.

Rothstein, S., Federspiel, W., and Little, S., 2006, "Predictive Model for Release from a Polymeric Microparticle," AIChE Annual Meeting, San Francisco, CA.

Rothstein, S.N., Federspiel, W., and Little, S., 2006, "Finite Element Model of Controlled Release Via the Degradation and Erosion of a Polymer Matrix," AIChE 2006 Annual Meeting, San Francisco, CA.

Budilarto, S.G., Eash, H.J., Hattler, B.G., and Federspiel, W., 2005, "Flow visualization study of a pulsating respiratory assist catheter," 53A.

Burgess, K.A., Yang, G., Wagner, W.R., and Federspiel, W., 2005, "Development of Microfabricated Biohybrid Artificial Lungs," 53A.

Eash, H.J., Budilarto, S.G., Hattler, B.G., and Federspiel, W., 2005, "Can random balloon pulsation enhance gas exchange in a pulsating respiratory support catheter?," 49A.

Eash, H.J., Hagglund, N.J., Frankowski, B.J., Hattler, B.J., and Federspiel, W., 2005, "Strategies to Improve Gas Exchange in a Respiratory Support Catheter: Random Balloon Pulsations and Rotational Fiber Bundles. Honorable Mention in Juried Competition," McGowan Institute for Regenerative Medicine Annual Retreat, Farmington PA.

Hagglund, N.J., Frankowski, B.J., Hattler, B.G., and Federspiel, W., 2005, "The potential use of rotational fiber bundles in respiratory assist catheters," 53A.

Oh, H.I., Solovan, J.C., Alikhani, A.H., and Federspiel, W., 2005, "Design of Specific Antibody Filters to Facilitate ABO-Blood Incompatible Transplantation Farmington," McGowan Institute Scientific Retreat, Farmington, PA.

Polk, A.A., McKeel, D.T., Federspiel, W., and Wagner, W.R., 2005, "A biohybrid lung prototype with endothelialized microporous hollow fibers in a rotating module," 55A.

Svitek, R.G., Frankowski, R.G., and Federspiel, W., 2005, "The effect of bundle porosity on the performance of a pumping paracorporeal assist lung using a rotating fiber bundle," 52A.

Eash, H.J., Frankowski, B.J., Hattler, B.G., and Federspiel, W., 2004, "Evaluation of local gas exchange in an artificial lung catheter," ASAIO-50th Anniversary Conference, Hilton Washington, Washington DC.

Eash, H.J., Frankowski, B.J., Hattler, B.G., and Federspiel, W., 2004, "Evaluation of local gas exchange in an artificial lung catheter," p. 153.

Wu, Z.J., and Federspiel, W., 2004, "DPIV flow study of a pulsating artificial lung catheter," p. 173.

Zinovik, I.N., Svitek, R.G., and Federspiel, W., 2004, "CFD analysis of hydrodynamic characteristics of a novel paracorporeal pumping artificial lung," p. 157.

Henchir, K.A., Lin, Q., Wagner, W.R., and Federspiel, W., 2003, "Microfabrication of biohybrid artificial lungs," Biomedical Engineering Society (BMES) Annual Fall Meeting, Nashville, TN.

Henchir, K.A., Wagner, W.R., and Federspiel, W., 2003, "Microfabrication of biohybrid artificial alveolar - capillary modules," pp. 65-150.

Kanick, S.C., Ghadiali, S., Doyle, W.J., and Federspiel, W.J., 2003, "Predicted Efect of Morphometric Measurement Technique on Mathematical Descriptions of Middle Ear Gas Exchange," 2003 Summer Bioengineering Conference, Key Biscayne, FL, p. 571.

Polk, A.A., Federspiel, W., and Wagner, W.R., 2003, "Modified microporous hollow fibers to support endothelial cell adhesion," p. 217.

Svitek, R.G., Frankowski, B.J., and Federspiel, W., 2003, "Development of an emergency respiratory support lung (ersl)," Biomedical Engineering Society (BMES) Annual Fall Meeting, Nashville, TN.

Svitek, R.G., Frankowski, B.J., and Federspiel, W., 2003, "Enhanced gas exchange in an emergency respiratory support lung," pp. 65-150.

Svitek, R.G., Golob, J.G., Frankowski, B.J., Hattler, B.G., and Federspiel, W., 2003, "An alternative approach to enhanced gas transfer in an intravascular respiratory support catheter," ASME Summer Bioengineering Conference, Key Biscayne, FL.

Zinovik, I.N., Svitek, R.G., and Federspiel, W., 2003, "Computational fluid dynamic (CFD) modeling of momentum and mass transfer in a novel paracorporeal pumping artificial lung," Abstract. BMES 2003 Annual Fall Meeting. Research, Education and Industry in Biomedical Engineering: Closing the Loop, Nashville, TN.

Hout, M.S., and Federspiel, W., 2002, "Kinetics of extracorporeal antibody removal by hollow fiber-based selective antibody filters," p. 196.

Nolan, T.D., Hattler, B.G., and Federspiel, W., 2002, "Development of a dynamic balloon volume sensor," p. 158.

Russian, H.J., Conover, S.P., Hattler, B.G., and Federspiel, W., 2002, "Evaluation of plasma resistant coatings for hollow fiber membranes," p. 155.

Snyder, T.A., Lund, L., Russian, H., Litwak, K.N., Hattler, B.G., Federspiel, W., and Wagner, W.R., 2002, "Assessing and improving the biocompatibility of an intravascular oxygenator," p. 37.

Snyder, T.A., Russian, H.J., Litwak, K.N., Federspiel, W., Hattler, B.G., and Wagner, W.R., 2002, "Assessing thrombosis of an intravascular respiratory support catheter," p. 154.

Garcia, M.Y., Federspiel, W., and Hattler, B.G., 2001, "Effect of vessel compliance on the in-vitro performance of a pulsating respiratory support catheter," p. 172.

Garcia, M.Y., Hattler, B.G., and Federspiel, W., 2001, "Effect of vessel compliance on the in-vitro performance of a pulsating respiratory support catheter," S5.

Ghadiali, S.N., Federspiel, W., Swarts, J.D., and Doyle, W.J., 2001, "Measurement of Eustachian Tube Mechanical Properties using a Modified Forced Response Test," ASME Summer Bioengineering Conference, Snowbird, UT.

Ghadiali, S.N., Swarts, J.D., Federspiel, W., Banks, J., Karnavas, W., and Doyle, W.J., 2001, "Demonstration of eustachian tube compliance using a modified forced response system," Association for Research in Otolaryngology Mid-winter Meeting, St. Petersburgh, FL.

Hout, M.S., and Federspiel, W., 2001, "Design of hollow fiber immunoadsorption modules for therapeutic antibody removal," p. 172.

Hout, M.S., and Federspiel, W., 2001, "Kinetics of antibody capture by hollow fiber-based selective antibody filters," S87.

Lund, L.W., Franklin-Ford, T., Russian, H.J., Hattler, B.G., and Federspiel, W., 2001, "A comparative in-vitro hemolysis study of a pulsating intravenous artificial lung," p. 115.

Snyder, T.A., Watach, M.K., Gordon, L.M., Litwak, K.N., Lund, L.W., Golob, J.F., Federspiel, W., Hattler, B.G., and Wagner, W.R., 2001, "Evaluating biocompatibility in an intravenous membrane oxygenator," p. 420.

Federspiel, W., and Hattler, B.G., 2000, "Development of an intravenous respiratory support catheter," S-2.

Golob, J.F., Federspiel, W., Merrill, T.L., Frankowski, B.J., Russian, H., Litwak, K., and Hattler, B.G., 2000, "Acute in-vivo testing of the Intravenous Membrane Oxygenator (IMO)," p. 180.

Hout, M.S., and Federspiel, W., 2000, "Kinetics of antibody removal by dialysis membrane immunoadsorption," p. 230.

Merrill, T.L., Hattler, B.G., and Federspiel, W., 2000, "Determining oxygen exchange from gas-side analysis in artificial lungs," p. 180.

Tulou, T., Hattler, B.G., and Federspiel, W., 2000, "Development of a balloon drive system for the Intravenous Membrane Oxygenator," p. 230.

Federspiel, W., Lund, L.W., Bultman, J.A., Wanant, S., Matoney, J., Golob, J.F., Frankowski, B.J., Watach, M., Litwak, P., and Hattler, B.G., 1999, "Ex-vivo testing of the intravenous membrane oxygenator (IMO)," p. 127.

Golob, J.F., Federspiel, W., Merrill, T.L., Frankowski, B.J., and Hattler, B.G., 1999, "Analysis of in-vivo flow effects on the in-vitro testing of intravascular oxygenators," p. 126.

Hout, M.S., LeJeune, K.E., Schaack, T.M., Bristow, D.K., and Federspiel, W., 1999, "Specific removal of anti-A and anti-B antibodies using modified dialysis filters," Proceedings of the First Joint BMES/EMBS Conference Serving Humanity, Advancing Technology, Atlanta, GA.

Hout, M.S., LeJeune, K.E., Schaak, T., Bristow, D., and Federspiel, W., 1999, "Specific removal of anti-A and anti-B antibodies using modified dialysis and plasmapheresis filters," p. 193.

Lund, L.W., and Federspiel, W., 1999, "Augmentation of oxygen flux from hollow fiber membranes in blood," Proceedings of the First Joint BMES/EMBS Conference Serving Humanity, Advancing Technology, Atlanta, GA.

Federspiel, W., 1998, "Mass transport and design considerations in artificial lungs," Third World Congress of Biomechanics, Sapporo, Japan.

Federspiel, W., and Hattler, B.G., 1998, "Engineering an intravenous artificial lung," Third World Congress of Biomechanics, Sapporo, Japan.

Guzman, A.M., Amon, C.H., Federspiel, W., and Hattler, B.G., 1998, "Spectral-element simulations of the flow kinematics in an intravenous membrane oxygenator," E. Dvorkin, S. Idelsohn, and E. Onate, eds., Computational Mechanics, CIMNE, Barcelona.

Hout, M.S., Hattler, B.G., and Federspiel, W., 1998, "A simple model of flow-dependent CO2 exchange in artificial lungs," p. 7.

Lund, L.W., Hattler, B.G., and Federspiel, W., 1998, "Analysis of condensation as a cause of plasma leakage in microporous membrane oxygenators," p. 23.

Federspiel, W., Hout, M.S., Hewitt, T.J., Lund, L.W., Heinrich, S.A., Macha, M., Litwak, P., Walters, F.R., Borovetz, H.S., and Hattler, B.G., 1997, "Development of a low flow resistance intravenous oxygenator," p. 14.

Federspiel, W., Walters, F., Hewitt, T., Hout, M., Lund, L., Sawzik, P., Reeder, G., Borovetz, H., and Hattler, B.G., 1996, "Recent progress in engineering the Pittsburgh intravenous membrane oxygenator," p. 71.

Federspiel, W., Walters, F.R., Hewitt, T., Hout, M.S., Lund, L., and Hattler, B.G., 1996, "Further development of an intravenous membrane oxygenator with active mixing.," S6.

Hout, M.S., Hattler, B.G., and Federspiel, W., 1996, "A simple model of flow dependent CO2 exchange in artificial lungs," S8.

Konishi, R., Firestone, W., Wagner, W., Federspiel, W., Konishi, H., Shimizu, R., and Hattler, B.G., 1996, "Nitric oxide presents human platelet adhesion on fiber membrane in whole blood," p. 72.

Lund, L., Federspiel, W., Taitel, F., and Hattler, B.G., 1996, "A novel method for measuring hollow fiber membrane permeability in a gas-liquid system," p. 67.

Lund, L.W., Federspiel, W., and Hattler, B.G., 1996, "Hollow fiber membrane permeability evaluation for use in intracorporeal artificial lungs," S8.

Macha, M., Federspiel, W., Lund, L., Sawzik, P., Litwak, P., Borovetz, H., Walters, F., Reeder, G., and Hattler, B.G., 1996, "Acute in-vivo studies of the Pittsburgh intravenous membrane oxygenator," p. 69.

Kameneva, M.V., Borovetz, H.S., Antaki, J.F., Federspiel, W., Kormos, R.L., and Griffith, B.P., 1995, "Effect of perfluorochemical emulsion on hemorheology and shear induced blood trauma. Possible mechanisms and future applications," ISOTT Meeting, Pittsburgh, PA.

Lund, L., Federspiel, W., Wallace, M., Walters, F., Borovetz, H., and Hattler, B.G., 1995, "Evaluation of a composite hollow fiber membrane for an intravenous membrane oxygenator," Fall Meeting of the Biomedical Engineering Society, Boston, MA.

Federspiel, W.J., 1993, "Modelling oxygen transport from capillary erythrocytes to muscle mitochondria," XXXII IUPS Congress, Glasgow.

Lai, J., Federspiel, W., Butler, J.P., and Loring, S.H., 1992, "A computational study of pleural pressure induced by lung motion," A1480.

Malai, K.P., and Federspiel, W., 1992, "Use of tracers to measure flow in branching microvessels," A2079.

Federspiel, W., 1991, "Gas dispersion in branching models of the pulmonary acinus," Winter Meeting of the ASME, Atlanta, GA.

Federspiel, W., 1990, "Fluid mechanics in alveolar ducts," Annual Fall Meeting of the Biomedical Engineering Society, Blacksburg, VA.

Federspiel, W., 1990, "Nonclassical features of gas transport and exchange at the alveolar level," First World Congress of Biomechanics, La Jolla, CA.

Federspiel, W., 1990, "Use of tracers to measure plasma flow within individual microvessels," A1251.

Federspiel, W.J., 1990, "Solute Transport in the Microcirculation," Fluid Mechanics Seminar Series, Massachusetts Institute of Technology.

Tsuda, A., Federspiel, W., Grant Jr, P.A., and Fredberg, J.J., 1989, "Axial dispersion of inert species in alveolated ducts," A686.

Federspiel, W., 1988, "Influence of the particulate nature of blood on pulmonary oxygen exchange," A170.

Federspiel, W., and Fredberg, J.J., 1988, "Gas dispersion in the pulmonary acinus.," Colloid and Surface Science Divisional Meeting of the American Chemical Society, State College, PA.

Federspiel, W., and Fredberg, J.J., 1987, "Gas transport in respiratory bronchioles and alveolar ducts," p. 1427.

Federspiel, W., and Fredberg, J.J., 1986, "Influence of structural complexity on axial dispersion in the acinus," p. 94.

Federspiel, W., and Popel, A.S., 1984, "A theoretical analysis of the effect of the particulate nature of blood on oxygen release in capillaries," p. 407.

Federspiel, W., 1983, "The effect of myoglobin concentration on muscle cell PO2 gradients," ISOTT, Ruston, LA.

Federspiel, W., and Cokelet, G.R., 1983, "Prediction of time dependent blood flow in small glass tubes," p. 233.

Federspiel, W., 1982, "Red Cell Spacing and Oxygen Transport in Capillaries," Texas A & M University, Microcirculation Research Institute.

Federspiel, W., Clark Jr, A., and Cokelet, G.R., 1982, "Oxygen delivery: the view from the red cell," p. 251.

Federspiel, W., 1984, "Modelling of Oxygen Transport in Capillaries," Department of Mechanical Engineering. Colloquium, University of Rochester.

Federspiel, W., 1984, "Oxygen Transport in Red Blood Cells," Rice University. Biomedical Engineering Laboratory.

Federspiel, W., 1986, "Gas Transport in Alveolar Ducts," Work in Progress Seminar Series, Harvard School of Public Health.

Federspiel, W., 1986, "Influence of Structural Complexity on Axial Dispersion in the Periphery of the Lung," Macrotransport Seminar Series, Massachusetts Institute of Technology.

Federspiel, W., 1986, "Oxygen Transport at the Microcirculatory Level," Department of Chemical Engineering Seminar, Tufts University.

Federspiel, W., 1987, "Gas Transport in the Pulmonary Acinus," Department of Bioengineering Seminar, University of Pennsylvania.

Federspiel, W., 1988, "Gas Dispersion in the Pulmonary Acinus," "Gas Dispersion in the Pulmonary Acinus," State College, PA.

Federspiel, W., 1988, "Solute Exchange in Capillaries: Answers to Questions Nobody Asks," Department of Biophysics Seminar, University of Rochester.

Federspiel, W., 1990, "Fluid Mechanics in Aveolar Ducts," Annual Fall Meeting of the Biomedical Engineering Society, Blacksburg, VA.

Federspiel, W., 1990, "Nonclassical Features of Gas Transport and Exchange at the Alveolar Level," First World Congress of Biomechanics, La Jolla, CA.

Federspiel, W., 1991, "Gas Dispersion in Branching Models of the Pulmonary Acinus," Winter Meeting of the ASME, Atlanta, GA.

Federspiel, W., 1991, "Gas Mixing in Branching Networks Airways," Work in Progress Seminar Series, Harvard School of Public Health.

Federspiel, W., 1992, "Flow and Transport in the Respiratory Zone of the Lung," Center for Theoretical and Computational Dynamics Seminar Series, Boston University.

Federspiel, W., 1992, "Using Tracers to Measure Microvascular Flow," Bioengineering Seminar Series, Penn State University.

Federspiel, W., 1993, "Flow Measurement in Microvessels using Tracers," Fluid Mechanics Seminar Series, Massachusetts Institute of Technology.

Federspiel, W., 1993, "On Using Tracers in Microvascular Flow Measurement," Department of Biophysics Seminar Series, University of Rochester School of Medicine.

Federspiel, W., 1996, "An Intravenous Membrane Oxygenator," Bend Research, Bend, OR.

Federspiel, W., 1996, "Development of a Novel Intravenous Membrane Oxygenator," Penn State University Bioengineering Program, Bioengineering Colloquium.

Federspiel, W., 1996, "Engineering a Novel Intravenous Membrane Oxygenator," Carnegie Mellon University Departments of Mechanical Engineering and Biomedical Engineering Lecture Series.

Federspiel, W., 1996, "Engineering a Novel Intravenous Oxygenator," Spring meeting of the American Association of Civil Engineers, Mechanics Division, Ft. Lauderdale, FL.

Federspiel, W., 1996, "Further Development of an Intravenous Membrane Oxygenator with Active Mixing," Annual Fall Meeting of the Biomedical Engineering Society, Penn State University, PA.

Federspiel, W., 1997, "Design Considerations for Artificial Lungs," Graduate Seminar Series, University of Pittsburgh Bioengineering Program.

Federspiel, W., 1997, "The Intravenous Membrane Oxygenator: An Idea Whose Time Has Come," 10th Annual Trauma Anesthesia and Critical Care Symposium, Baltimore, MD.

Federspiel, W., 1998, "Engineering an Intravenous Artificial Lung," Third World Congress of Biomechanics, Sapporo, Japan.

Federspiel, W., 1998, "Mass Transport and Design Considerations in Artificial Lungs," Third World Congress of Biomechanics, Sapporo, Japan.

Federspiel, W., 1998, "Paradigms of Bioengineering: Artificial Lung Development at the University of Pittsburgh," Respiratory Mechanics Seminar, Boston University Department of Bioengineering.

Federspiel, W., 1999, "Engineering Considerations in the Development of Artificial Lungs," Bioengineering Graduate Seminars, Carnegie Mellon University, Biomedical Engineering Program.

Federspiel, W., 2000, "Development of an Intravenous Respiratory Support Catheter," Annual Fall Meeting of the Biomedical Engineering Society, Seattle, WA.

Federspiel, W., 2001, "Chemical Engineering of Home Brewing," Undergraduate AIChE Student Talks, University of Pittsburgh, Department of Chemical Engineering.

Federspiel, W., 2001, "Development of Next Generation Artificial Lungs," Biomedical Engineering Program Seminar Series, Carnegie Mellon University.

Federspiel, W., 2001, "Engineering of Implantable Artificial Lungs," Graduate Seminar Series, University of Pittsburgh, Department of Bioengineering.

Federspiel, W., 2001, "Research in the Artificial Lung Laboratory," University of Pittsburgh, Department of Surgery, Chairman's Conference.

Federspiel, W., 2002, "Alternative Means of Enhancing Gas Transfer in a Respiratory Support Catheter," Annual Fall Meeting of the Biomedical Engineering Society, Houston, TX.

Federspiel, W., 2002, "Technology Transfer of Artificial Lung Laboratory Research," Leadership Pittsburgh Conference, Pittsburgh, PA.

Federspiel, W., 2002, "The Respiratory Support Catheter," 48th Annual ASAIO Meeting. Satellite Symposium on Artificial Lungs.

Federspiel, W., 2003, "Artificial Lungs for Extrapulmonary Respiratory Assist," Invited Whitaker Colloquium Speaker, University of Rochester, Department of Biomedical Engineering.

Federspiel, W., 2003, "Development of an Emergency Respiratory Support Lung," 25th Annual EMBS Conference. Symposium: Cardiopulmonary Critical Care Engineering.

Federspiel, W., 2003, "Development of Next Generation Artificial Lungs," Peri-Natal Grand Rounds, University of Alabama at Birmingham, Department of Pediatrics.

Federspiel, W., 2003, "Engineering of Artificial Lungs," Biomedical Engineering, Carnegie Mellon University.

Federspiel, W., 2003, "Update on the Respiratory Support Catheter Project," 9th Annual ASAIO Meeting. Symposium: Artificial Lung and Gas Exchange.

Federspiel, W., 2005, "Development of Novel Respiratory Support Devices for Acute Lung Failure," Florida State University.

Federspiel, W., 2005, "Updates in Artificial Lung Technology: Respiratory Assist Devices," Cleveland Clinic Foundation Lung Summit 2005: Innovations in Pulmonary and Critical Care.

Federspiel, W., 2006, "Centi Scale Therapeutic Medical Devices," University of Connecticut, Department of Chemical Materials and Biomolecular Engineering.

Federspiel, W., 2006, "Extrapulmonary Respiratory Assist: Help for the Failing Lung," Invited Speaker: Mini Symposium: Emerging Technologies for Cardio-Respiratory Failure, 3rd International Symposium on Respiratory Diseases/ 14th Congress of the Asia Pacific Association for Respiratory Care, Shanghai, China.

Federspiel, W., 2006, "Supporting the Failing Lung: The Need for New Strategies," Biomedical Engineering Society Annual Fall Meeting, Respiratory Engineering - Innovative Strategies for Respiratory Support Session, Chicago, Il.

Federspiel, W., 2006, "Systems Engineering of Pheresis Intervention for Sepsis: SEPsIS; A Bioengineering Research Partnership (BRP)," McGowan Institute Scientific Retreat.

Federspiel, W., 2006, "The State of the Artificial Lung," Lunch Symposium, 52 Annual Conference of the American Society for Artificial Internal Organs, Chicago, Il.

Federspiel, W., 2006, "There's Plenty of Room at the Top, too," Northeastern University, Department of Chemical Engineering.

Federspiel, W., 2006, "There's Plenty of Room at the Top, too," University of South Alabama, College of Engineering.

Federspiel, W., 2007, "And there is Plenty of Room at the Top, too," Vanderbilt University, Department of Chemical Engineering. Nashville, TN.

Federspiel, W., 2007, "Developing Medical Devices for the Failing Lung: Rules of the Endless Road," Keynote Speaker, Boston University Biomedical Engineering Day, Boston, MA.

Federspiel, W., 2007, "Developing Medical Devices to Support the Failing Lung," Charles Stark Draper Laboratory, Boston, MA.

Federspiel, W., 2007, "Still Plenty of Room at the Top, too," University of Texas at Austin, College of Engineering. Austin, TX.

Federspiel, W., 2008, "Respiratory Device Development using Chemical Engineering Principles," AICHE Pittsburgh Section Meeting, Pittsburgh, PA.

Federspiel, W., 2008, "Respiratory Device Development," National Energy Technology Laboratory, United States Department of Energy. Pittsburgh, PA.

Federspiel, W., 2009, "Artificial Organs," Visiting Professor Presentation, Aachen University, Aachen Germany.

Federspiel, W., 2010, "Progress in Developing an Artificial Lung," Cafe Scientique, Carnegie Science Center, Pittsburgh, PA.

Federspiel, W., 2011, "Critical Voices: Panelist Presentation," Beth Israel Deaconess Medical Center, Board of Overseers, Boston, MA.

Federspiel, W., 2011, "Research Commercialization in Academia - The Life Cycle of a Medical Device Start-Up Company," Katz Business School MBA course speaker, University of Pittsburgh.

Federspiel, W., 2011, "Towards Improved Respiratory Assist Devices," Beth Israel Deaconess Medical Center, Surgical Grand Rounds, Boston, MA.

Federspiel, W., 2011, "Towards Improved Respiratory Assist Devices," UPMC Pulmonary Grand Rounds.

Federspiel, W., 2012, "The State of the Bioengineering Graduate Program," Bioengineering Graduate Seminar, University of Pittsburgh.

Federspiel, W.J., 2007, "A-Lung and Beyond: New Device for the Failing Lung," The Innovators Conference, Pittsburgh, PA.

2000, "Advances in Intravascular Respiratory Support," 46th Annual ASAIO Meeting. Satellite Symposium on Artificial Lungs.

DiLeo, M.V., and Federspiel, W., 2010, "Selective improvement of TNF capture in a cytokine hemoadsorption device using immobilized anti-TNF," University of Pittsburgh Safar Conference.

Kimmel, J., Lacko, C., Kellum, J., and Federspiel, W., 2010, "TNF Capture Dynamics within Hemoadsorption Beads Used to Treat Sepsis," University of Pittsburgh Safar Conference.

Kimmel, J.D., Arazawa, D., and Federspiel, W., 2012, "Bioactive Hollow Fiber Membranes Coated with Chitosan and Carbonic Anhydrase for Artificial Lung Applications," University of Pittsburgh Postdoctoral Association 2012 Postdoctoral Data & Dine Symposium.

Federspiel, W.J., Frankowski, B.J., Yoshida, T., and Vernucci, P.J., 2013, "Oxygen depletion devices and methods for removing oxygen from red blood cells," 14/038,001.

Federspiel, W.J., Arazawa, D.T., and Kimmel, J.D., 2013, "Devices, Systems And Methods For Reducing The Concentration Of Carbon Dioxide In Blood," PCT/US2013/046042.

Federspiel, W.J., Frankowski, B.J., Antaki, J., Bermudez, C., Jeffries, R.G., and Wagner, W.R., 2013, "Extracorporeal Ambulator Assist Lung," PCT/US2013/072286.

Kellum, J.A., Federspiel, W.J., and Cove, M.E., 2013, "Removal of Carbon Dioxide via Dialysis," 61/754,435.

Federspiel, W.J., Kellum, J.A., and Singbartl, K., 2012, "Devices Systems and Methods for Cell Modification," PCT/US2010/051772.

Federspiel, W.J., Arazawa, D.T., and Kimmel, J.D., 2012, "Devices, Systems And Methods For Reducing The Concentration Of Carbon Dioxide In Blood," 61/660,013.

Federspiel, W.J., Frankowski, B., Antaki, J., Burgreen, G., Bermudez, C., and Jeffries, R.G., 2012, "Paracorporeal Ambulatory Artificial Lung (PAAL)," 61/730,581.

Federspiel, W.J., Yoshida, T., Vernucci, P.J., Frankowski, B.J., and Wheeler Lund, L., 2012, "Removal Of Oxygen From Biological Fluids," 13/387,528.

Federspiel, W.J., Russell, A.J., Oh, H., and Kaar, J., 2012, "Devices, systems and methods for reducing the concentration of a chemical entity in fluids," 8,323,379.

Federspiel, W.J., Russell, A.J., Oh, H., and Kaar, J., 2011, "Devices, systems and methods for reducing the concentration of a chemical entity in fluids," 13/280,033.

Federspiel, W.J., Frankowski, B.J., Yoshida, T., and Vernucci, P.J., 2011, "Oxygen depletion devices and methods for removing oxygen from red blood cells," 13/115,532.

Federspiel, W.J., Frankowski, B.J., Yoshida, T., and Vernucci, P.J., 2013, "Oxygen depletion devices and methods for removing oxygen from red blood cells," 8,569,052.

Federspiel, W.J., Kellum, J.A., and Singbartl, K., 2010, "Devices Systems and Methods for Cell Modification," 13/500,163.

Federspiel, W.J., Yoshida, T., Vernucci, P.J., Frankowski, B.J., and Wheeler Lund, L., 2010, "Removal of Oxygen from Biological Fluids," 61/230,575.

Federspiel, W.J., Russel, A.J., Oh, H., and Kaar, J., 2011, "Devices, Systems, and Methods for Reducing the Concentration of a Chemical Entity in Fluids," 8,043,411.

Federspiel, W.J., Russell, A.J., Oh, H., and Kaar, J., 2010, "Devices, Systems, and Methods for Reducing the Concentration of a Chemical Entity in Fluids," 12/816,455.

Federspiel, W.J., Yoshida, T., Vernucci, P.J., Frankowski, B.J., and Wheeler Lund, L., 2010, "Removal of Oxygen from Biological Fluids," PCT/US2010/44045.

Frankowski, B.J., Federspiel, W.J., Mihelc, K.M., and Lieber, S.C., 2009, "Intracorporeal Gas Exchange Devices, Systems and Methods," PCT/US2009/033399.

Frankowski, B.J., Federspiel, W.J., Mihelc, K.M., and Lieber, S.C., 2009, "Intracorporeal Gas Exchange Devices, Systems and Methods," 12/865,958.

Federspiel, W.J., Russell, A.J., Oh, H., and Kaar, J., 2010, "Devices, Systems, and Methods for Reducing the Concentration of a Chemical Entity in Fluids," 7,763,097.

Federspiel, W.J., Russell, A.J., Oh, H., and Kaar, J., 2007, "Devices, Systems, and Methods for Reducing the Concentration of a Chemical Entity in Fluids," 11,811,265.

Federspiel, W.J., Russell, A.J., Oh, H., and Kaar, J., 2007, "Devices, Systems, and Methods for Reducing the Concentration of a Chemical Entity in Fluids," PCT/US2007/013563.

Hattler, B.G., Federspiel, W.J., and Frankowski, B.J., 2006, "Percutaneous Respiratory Assist Catheter Incorporating A Spinning Fiber Bundle," PCT/US06/15002.

Federspiel, W.J., Frankowski, B.J., Mack, B.C., Morley, S.W., Scott, W., Rosenberg, M., and Svitek, R.G., 2011, "Paracorporeal Respiratory Assist Lung," 7,927,544.

Federspiel, W.J., Frankowski, B.J., Mack, B.C., Morley, S.W., Rosenberg, M., and Svitek, R.G., 2006, "Paracorporeal Respiratory Assist Lung," 11/408,650.

Federspiel, W.J., Frankowski, B.J., Mack, B.C., Morley, S.W., Rosenberg, M., and Svitek, R.G., 2006, "Paracorporeal Respiratory Assist Lung," PCT/US06/15000.

Hattler, B.G., Federspiel, W.J., and Frankowski, B.J., 2006, "Percutaneous Respiratory Assist Catheter Incorporating A Spinning Fiber Bundle," 60/688,861.

Frankowski, B.J., Federspiel, W.J., Golob Jr., J.F., and Hattler, B.G., 2003, "Magnetic Guidewires," 10/434,555.

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