Radiation dermatitis affects over four million cancer patients in the US. In addition to discomfort and lowering the quality of life, this disease also negatively affects cancer treatment compliance. Radiation-induced skin damage results from increased mitochondrial ROS (reactive oxygen species) and causes redness, swelling, blistering, and/or itchy skin. Currently, only symptomatic treatments exist for managing radiation dermatitis; there are no curative or preventative treatments options available to the patients. ContegoDerm is a topical cream with antioxidant properties that has been shown to significantly reduce the clinical manifestations of radiation-induced skin damage when applied either before or immediately after radiation exposure in pre-clinical studies.