Jillian Tengood Hillman

Faculty Mentor: Steven Little

Update: Dr. Jillian Tengood Hillman has joined the laboratory of Dr. Robert Levy at the Children's Hospital of Philadelphia Research Institute as a Postdoctoral Fellow. Jillian will be researching the use of magnetic nanoparticles in combination with drug and cellular therapies for heart disease.

Research: Dr. Tengood's current research focuses on the use of magnetic nanoparticles in combination with drug and cellular therapies for heart disease. Her former research focused on the development of an externally regulated "synthetic capillary system" capable of providing angiogenesis promoters to a wound site in a temporal manner. This construct is expected to facilitate early tissue growth via the development of native vasculature. Porous hollow fibers fabricated from natural (e.g., cellulose) and custom-developed biodegradable elastomers will be used for this purpose. Specific Aims: (1) Fabrication and characterization of hollow fibers from natural and synthetic materials that demonstrate triggerable dissolution, (2) Controlled release from hollow fibers in vitro, and (3) In vitro and in vivo temporal delivery to promote angiogenesis using a "synthetic capillary.

Publications:

• Tengood JE, Kovach KM, Vescovi PE, Russell A, Little SR. "Sequential Delivery of Vascular Endothelial Growth Factor and Sphingosine 1-Phosphate for Angiogenesis". Biomaterials30(): 7805-7812, 2010
• Tengood J, Ridenour R, Brodsky B, Russell A, Little S. "Sequential Delivery of basic Fibroblast Growth Factor and Platelet Derived Growth Factor for Angiogenesis". Tissue Engineering2010(): , 2010
• Tengood J.E., Maskarinec D., Ridenour R., Little S.R. "A Mathematical Model for Release of Biologics from Porous Hollow Fibers". [J Biomed Mater Res A. 2012 Mar 15;100(4):817-26. Epub 2012 Jan 24]