Pitt | Swanson Engineering
Ling Zhang

Ling Zhang

ling.jpg

Research Interests

Interactions between neural stem cell and biomaterials; Regulation of neural stem cells by electrical stimulation or combination of chemical, topological and electrical cues; Application of neural stem cells, hydrogel and electrical stimulation to help neuronal regeneration after diseases or injuries of the central nervous system, such as traumatic brain injury (TBI); Surface modification of neural electrodes with biomolecules or stem cells to reduce the inflammatory reaction in spinal cord and dorsal root ganglion.

Education

Doctor of Philosophy 
Biophysics 
Tsinghua University, China 
2008

Master of Science 
Pharmacology 
Chinese Academy of Medical Science 
and Peking Union Medical College (CAMS & PUMC) 
2003

Bachelor of Science 
Biochemistry 
Jilin University, China 
2000


Research Experience

2008-present 
Neural stem cell and biological hydrogel for central nervous system regeneration; Proliferation and differentiation of neural stem cell on peptide modified surface; Biocompatibility of neural electrodes with central and peripheral nervous system.


2003-2008 
Combination of adipose-derived stem cell and porous chitosan scaffold to construct a tissue engineered small-diameter blood vessel.


2000-2003 
Hematopoiesis of Smad3 -knockout mouse and initiate immune reaction of dendritic cells derived from bone marrows of Smad3 -knockout mouse.

Publications

  1. Zhang L, Zheng Z, Xi J, Gao Y, Yandao Gong, Nanming Zhao, Xiufang Zhang. Improved mechanical property and biocompatibility of poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) for blood vessel tissue engineering by blending with poly (propylene carbonate). European Polymer Journal, 2007, 43: 2975-2986
  2. Zhang L , Ao Q, Wang A, Lu G, Kong L, Gong Y, Zhao N, Zhang X. A sandwich tubular scaffold derived from chitosan for blood vessel tissue engineering. J Biomed Mater Res . 2006; 77A: 277-284
  3. Zhang L , Gao Y, Kong L, Gong Y, Zhao N, Zhang X. Compatibility of chitosan-gelatin films with adipose tissue derived stromal cells. Tsinghua Science and Technology . 2006; 11(4): 421-426
  4. Zhang L , Ao Q, He Q, Wang G, Xi J, Gong Y, Zhang X. Preparation of scaffolds from PHBHHx/PPC blended materials and evaluation of their mechanical properties for blood vessel tissue engineering. Journal of Clinical Rehabilitative Tissue Engineering Research . 2007,11(2):6950-6953.
  5. Xi J, Zhang L , Zheng Z, Chen G, Gong Y, Zhao N, Zhang X, Preparation and evaluation of porous poly (3-hydroxybutyrate-co-3-hydroxyhexanoate)/ hydroxyapatite composite scaffolds, Journal of Biomaterials Applications, (accepted)
  6. Zhenhuan Zheng, Ling Zhang , Lijun Kong, Aijun Wang, Yandao Gong, Xiufang Zhang. The behavior of MC3T3-E1 cells on chitosan/poly-L-lysine composite films: Effect of nanotopography, surface chemistry, and wettability. J Biomed Mater Res. 2009; 89A: 453â€"465
  7. Gao Y, Kong L, Zhang L , Gong Y, Chen G, Zhao N, Zhang X. Improvement of mechanical properties of poly (DL-lactide) films by blending of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate). European Polymer Journal . 2006; 42: 764-775.
  8. Zhang L , Aijun Wang, Yuan Gao, Qiang Ao, Yandao Gong, Nanming Zhao, Xiufang Zhang, A Novel Chitosan-based Tubular scaffold for Blood Vessel Tissue Engineering, The 8th Annual Meeting of Tissue Engineering Society International, Oct.22-25, 2005, Shanghai, China. ( Oral presentation )
  9. Zhang L , Zhao CH. TGF-β and the regulation of hematopoiesis. Foreign Medical Sciences Blood Transfusion and Hematology . 2004; 27(1):15-17
  10. Zhang L , Sun Z, Shen A, Ma L, Jiang X, Ma G, Yang X, Zhao CH. The Effects of the Smad3-knockout on the Hematopoiesis of Mouse. Chinese Journal of Biotechnology . 2003; 19(4): 428-432

Awards/Honors

Guanghua scholarship of Tsinghua University in 2005, and 2006.

Fellowship in Jilin University in 1998, and 1999