Biomedical devices implanted in the nervous system hold the
potential to treat anything from paralysis to Parkinson’s, but many of these
devices are rejected by the body. As a PhD Candidate in Dr. Cui’s lab, I am
developing new technologies to improve the outlook for neural technologies. I
am approaching this from a few angles:
Additionally, I am working with
collaboration between our lab and Dr. Charles Sfier’s lab to translate some of
our technology to reduce inflammation related complications for dental
implants. Towards this end, our technology has won grand prizes at University
of Pittsburgh’s Pittsburgh Innovation Challenge 2015, Michael G. Wells Student
Healthcare Entrepreneurship Competition 2015, and the Randall Family Big Idea
Presentations and Publications:
James Eles, Alberto Vazquez, TK Kozai, X. Tracy Cui, In vivo imaging of neuronal calcium during electrode implantation: spatial and temporal mapping of damage and recovery, Accepted by Biomaterials.
Degenhart AD*, Eles JR*, Dum R, Mischel JL, Smalianchuk I, Endler B, Ashmore RC, Tyler-Kabara EC, Hatsopoulos NG, Wang W, Batista AP, Cui XT. Histological evaluation of a chronically-implanted electrocorticographic electrode grid in a non-human primate. Journal of Neural Engineering. 2016, 13(4): 046019 [Link] [* Authors contributed equally]
Kozai TDY, Eles JR, Vazquez AL, Cui XT. Two-photon imaging of chronically implanted neural electrodes: Sealant Methods and new insights. Journal of Neuroscience Methods. 2015, 258(30) 46-55. [Link]
JR, Zheng X, Prabhu P,
Cui XT. Carbon Nanotube/Conducting
Polymer Coatings for
Electrically Stimulated Drug Release from intramuscular electrodes
Biomedical Engineering Society Annual Meeting; 2015 Oct 7-10; Tampa, FL.,
JR, Kolarcik CL,
Venpati SK, Cui XT. Combination electrical stimulation and pulsatile
therapeutic-release strategies to preserve neuromuscular junction health in
peripheral nerve injury. Poster presented at: Neuroscience 2014, Society for
Neuroscience; 2014 Nov 15-19; Washington D.C., USA.
JR, Degenhart AD, Dum
RP, Mischel JL, Smalianchuk I, Endler BM, Ashmore RC, Tyler-Kabara EC,
Hastopoulos NG, Wang W, Batista AP, Cui XT. Histological Evaluation of a
Chronically-implanted Electrocorticographic Electrode Grid in a Non-Human
Primate. Poster presented at: BRAIN
Grand Challenges Conference, IEEE EMBS; 2014 Nov 13-14; Washington D.C., USA.
JR, Weaver CL, Snyder
NR, Cui XT. Ultrastructural characterization of tissue reaction to neural probe
implantation. Poster presented at: Neuroscience 2013, Society for Neuroscience;
2013 Nov 9-13; San Diego, California, USA.
JR, Tremblay ME,
Majewska AK. Visual Deprivation Regulates the GLT-1 Promoter in Cortical
Astrocytes. Poster presented at: University of Rochester Center for Visual
Sciences Summer Fellowship Poster Session 2011, University of Rochester Center
for Visual Sciences; 2011 August; Rochester, NY ,USA.