1178A, Benedum Hall
Understanding the signaling mechanisms in human embryonic stem cells can help us to improve the differentiation process. The overall goal of my project is to understand the signaling crosstalk between different growth factors that are used to differentiate the human embryonic stem cells towards definitive endoderm. I am working with PI3K, TGF-beta and Wnt pathways which are commonly modified to differentiate human embryonic stem cells towards pancreatic beta cells. High throughput analytical techniques such as Multiplex and LiCOR are employed to study the crosstalk between the different growth factors. Ongoing projects which support this goal include:
1. Dynamics of TGF beta pathway molecules during early and late endoderm differentiation
2. Crosstalk between TGF beta and PI3K/AKT pathway during endoderm differentiation
2009 PhD, Biochemistry, Central Leather Research Institute, Chennai, India.
Thesis Topic: Studies on the role of zinc induced metallothione in in regulating chromium toxicity in human lymphocytes
2000 MSc, Biochemistry, Saurastra College, Madurai, India
Sankaramanivel S, Blose KJ, Philips BJ, Rubin PJ, Vorp DA. Synergistic effects of TGF-beta and uniaxial strain on differentiation of human adipose derived stem cells to smooth muscle cells.
McGowan Institute Annual Retreat, Mar, 2012, Nemacolin, PA
AHA Fellow Research Day, Feb, 2012, Pittsburgh, PA.
Sankaramanivel S, Blose KJ, Jeffrey K, Joseph ME, Deborah C, Rao J, Vorp, DA. Synergistic effects of chemical and mechanical stimulation towards differentiation of human pericytes to smooth muscle cells and its application, Biomechanical Day, Sep-2011, Carnegie Mellon University, Pittsburgh, PA
Luzo A, Sankaramanivel S, Duarte A, Andreoli M, Ribeiro T, Bordeaux-Rego P, Kharmandaya P, Boin I, Costa F, Saad S. Mesenchymal stem cells obtained from adipose tissue and umbilical cord blood and their ability to differentiate into functional hepatocytes. Mar, 2011, EASL, Berlin, Germany.