Pitt | Swanson Engineering
Porohyperelastic Simulation of the Eye
  • Porohyperelastic Simulation of the Eye


    Primary open angle glaucoma (POAG) is a loss of vision caused by death of the retinal ganglion cells in the back of your eye. Intraocular pressure in the anterior and posterior chambers of your eye both play a role in the onset and development of this disease. It is clear that an optimum tissue stiffness and fluid permeability of tissues in both the anterior and posterior chambers is necessary to promote the health, viability, and function of retinal ganglion cells.  Our research laboratory is utilizing a porohyperelastic computational approach to better understand how the mechanical stiffness and fluid resistance properties of the eye govern its biomechanical environment. We are using simulations in which both the anterior and posterior chambers are considered to generate exploratory hypotheses regarding IOP regulation and biomechanical homeostasis in the eye (Ayyalasomayajula A et al., 2016).


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