Pitt | Swanson Engineering
Biomechanical Modeling of the Gastrointestinal Tract

Crohn’s disease is a clinically challenging inflammatory condition capable of afflicting the entire gastro-intestinal tract. A widely used surgical treatment for Crohn’s disease is a procedure called the Heineke-Mikulicz strictureplasty. In this procedure, a longitudinal cut is made in the intestinal wall and new sutures are added to redistribute wall stresses. Our goal has been to computationally model this procedure in order to better understand the intestinal remodeling which follows strictureplasty, and to design a better surgical solution (length of incision, number of sutures, etc.).


Related Publications

1.    Tsamis A, Pocivavsek L, Vorp DA, “ Elasticity and geometry: a computational model of the Heineke-Mikulicz strictureplasty”, Biomechanics and Modeling in Mechanobiology, 2014 Nov;13(6):1185-98, PMID: 24671519