Funded Research

55

Total Funded Projects

1MIL+

Total Seed-funding

39

Clinical coPIs

63

Technical coPIs

Funded Projects

OrganEvac/Whole Organ Thrombolysis Device

Currently there are around 14,000 individuals listed on the liver transplant wait list, with only 7000 getting transplants and 2200 of them die waiting for livers. The early stage seed grant will demonstrate proof of concept of a new technology to lyse thrombus in human liver tissue. The technology . . .

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A Novel Thermal Block Technology to Block Nerve Conduction

Many chronic disorders like obesity, chronic pain, heart failure and bladder voiding dysfunction are caused by neuronal overactivity in the peripheral or central nervous system. Currently, there is no safe and reliable method to suppress or block peripheral nerve activity that can be used for these . . .

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Objective Postpartum Uterine Tone Monitoring

Death from postpartum hemorrhage is one of the most common preventable causes of maternal death in the United States, and is the single leading cause of maternal mortality worldwide. There is currently no objective measurement of uterine contraction, which is most responsible for postpartum hemorrha . . .

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TopoGraft 2.0: Anti-platelet surfaces for bypass grafts and artificial hearts

Medical devices such as artificial vascular grafts, total artificial hearts (TAH) and left ventricular assist devices (LVADs) have an unacceptable rate of graft loss, stroke and device failure due to unwanted platelet adhesion and thrombosis. The grant will be used to develop an improved artificial . . .

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RegenMatrix: Collagen-mimetic Bioactive Hydrogels for Bone Regeneration

20% of high-impact bone fractures result in delayed healing or non-union, but there is no effective treatment for induction of bone regeneration. RegenMatrix is a bioactive hydrogel, designed to mimic the bone regenerative microenvironment, which would improve on the limited bone regrowth outcomes f . . .

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The Esophocclude: Temporary Esophagus Occlusion for Emergent Intubation

Gastric aspiration is a devastating complication of intubation and other clinical scenarios. An estimated 3.5% of intubations result in aspiration. 8-10% of affected patients die, and others experience repeated lung infections. Worse, it is underreported and misdiagnosed. The Esophocclude is a med . . .

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Intrapancreatic Lipid Nanoparticles to Treat Diabetes

Diabetes mellitus has become a massive worldwide problem. In the US, it is the number one biomedical financial burden. Recent analyses reveal that nearly 30 million Americans suffer from diabetes mellitus. The grant will be used for the development of a nanoparticle technology for the treatment of . . .

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Motorized, Flexible Arm Retractor for Open Abdominal Surgery

Open abdominal surgery presents several challenges: anatomic complexity, depth of the cavity, fragility of the different organs present, and technical issues exacerbated by morbid obesity. Current retractor technology is bulky, obtrusive, inefficient, and hasn’t notably progressed in 30 years. The t . . .

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Hemoglobin Replacement Device Treatment of Sickle Cell Disease

Sickle Cell Disease, also known as hemoglobinopathy, is a genetic defect resulting in abnormal structure of the hemoglobin molecules. Abnormally shaped RBCs cause gradual, eventually fatal damage to all organs. Transfusion of normal RBCs prolongs life, but repeated transfusion leads to alloimmunizat . . .

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Minimally Invasive Delivery of Therapeutic Cells to Abdominal Aortic Aneurysm

7-10% of US males are affected by abdominal aortic aneurysm, a focal balloon-like dilatation of the distal aorta. A rupture is life-threatening, being 13th leading cause of death in the US. Large aneurysms can be treated with surgery, but there is no existing treatment for small aneurysms, which gro . . .

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I-HITS: Individualized Hand Improvement and Tracking System After Stroke

Stroke, or the sudden interruption of blood supply of the brain, is the leading cause of disability in the United States. Eighty five percent of the 795,000 individuals who sustain a stroke annually in the United States have difficulty moving one arm or hand, significantly affecting their long-term . . .

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Novel Ventriculoamniotic Shunt for Fetal Aqueductal Stenosis

Severe fetal central nervous system (CNS) hydrocephalus occurs 3-5 cases per 10,000 deliveries. Aqueductal Stenosis (AS) is a developmental anomaly that causes hydrocephalus by obstructing the brain’s ventricular system. Older style shunts are still placed in fetuses with lesions other than AS, and . . .

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ThreadRite IV: Novel Way to Quickly and Accurately Place IV Catheters

Peripheral vascular access drug delivery is a mainstay of modern healthcare. Virtually all ER and hospital patients get peripheral IV lines, yet under half of attempted placements are successful. With 1.2 billion pIVs purchased in N. America last year, there is significant risks of extravascular inj . . .

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