Pitt | Swanson Engineering
Parker, Robert S
Chem/Petroleum Engineering
Parker, Robert S
Professor and B.P. America Faculty Fellow
Faculty
Professor
Office: 931 Benedum Hall
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Ph.D. in Chemical Engineering, University of Delaware, 1999

B.S. in Chemical Engineering, University of Rochester, 1994

(2011) David L. Himmelblau Award from CAST Division of AIChE (with F.J. Doyle III and E.P. Gatzke).

(2009) 2009 Paper of the Year, Computers and Chemical Engineering (with J.M. Harrold).

(2008) Carnegie Science Center Excellence in Higher Education Award (with J.J. McCarthy and M. Bestefield-Sacre).

(2005) CNG Faculty Fellowship.

(2004) Engineering Student Council Faculty Honor Roll.

(2002) Engineering Student Council Faculty Honor Roll.

(2002) National Science Foundation CAREER Award.

(2002) School of Engineering Board of Visitors Award.

(2002) Fulton C. Noss Faculty Fellowship.

(2000) Lai Family Foundation New Faculty Fellow.

(1999) NSF Engineering Education Workshop Participant.

(1998) American Control Conference Best Talk in Session.

(1998) Chemical Engineering Teaching Fellowship.

(1997) Kenan Award Symposium Speaker, Union Carbide (WVa.).

(1997) International Society for Artifcial Organs Graduate Student Award.

(1996) IEEE{EMBS Whitaker Foundation Student Paper Competition Finalist.

(1995) National Science Foundation Fellowship Honorable Mention.

(1994) Chemical Engineering Merit Scholarship, Purdue University.

(1994) B.S. degree in Chemical Engineering with Distinction.

(1994) Andrews Fellowship, Purdue University.

(1992) NCAA Division III Academic All-American.

(1990) Bausch and Lomb Scholarship.

Balius, T., Eiseman, J.L., Soni, A.S., and Parker, R.S., "A Mathematical Tool for Analyzing Two-Drug Chemotherapy," Comput. Biol. Med., Manuscript submitted for publication.

Ho, T., Clermont, G., and Parker, R.S., "Mathematical Model of Neutrophil Dynamics and Responses in Inflammation Challenge and Cancer Treatment," Computers and Chemical Engineering, Manuscript submitted for publication.

Hogg, J.S., Knab, T., Rimmele, T., Valenti, I.E., Fedorchak, M.V., Federspiel, W.J., Kellum, J.A., Clermont, G., and Parker, R.S., "Modeling and Treatment of Acute Inflammation Part II: Model-Based control of Blood Purification," J. Process Control, Manuscript submitted for publication.

Roy, A., Daun-Gruhn, S., Clermont, G., Rubin, J., Vodovotz, Y., Lagoa, C., and Parker, R.S., "Modeling and Treatment of Acute Inflammation, Part I: A Mathematical Model of Acute Inflammatory Response to Endotoxin Challenge," J. Process Control, Manuscript submitted for publication.

Ho, T., Clermont, G., and Parker, R.S., 2012, "Modeling Neutrophil Dynamics in Sepsis and Cancer Treatment," CPC 8, Savannah, GA.

Song, S.O., Hogg, J., Peng, Z.Y., Parker, R.S., Kellum, J.A., and Clermont, G., 2012, "Ensemble Models of Neutrophil Trafficking in Severe Sepsis," PLoS Computational Biology, no.3, e1002422.

Battaglia, M.A., and Parker, R.S., 2011, "PK/PD Modeling of Intracellular Gemcitabine Triphosphate Accumulation: Translating in vitro to in vivo," IET Systems Biology Special Issue from the Third International Conference on Foundations of Systems Biology in Engineering, no.1, pp. 34-43.

Kimmel, J.D., Harbert, E.M., Parker, R.S., and Federspiel, W.J., 2011, "Modeling Competitive Cytokine Adsorption Dynamics Within Hemoadsorption Beads Used to Treat Sepsis," J. Chromatography A, no.44, pp. 8013-8020.

Kotchey, N.M., Adachi, K., Zahid, M., Inagaki, K., Charan, R., Parker, R.S., and Nakai, H., 2011, "A Potential Role of Distinctively Delayed Blood Clearance of Reconbinant Adeno-Associated Virus Serotype 9 in robust cardiac transduction," Molecular Therapy, no.6, pp. 1079-1089.

McCarthy, J.J., Parker, R.S., Abatan, A.A., and Besterfield-Sacre, M., 2011, "Building an Evaluation Strategy for an Integrated Curriculum in Chemical Engineering," Advances in Engineering Education, no.4.

Parker, R.S., and Clermont, G., 2010, "Systems Engineering Medicine: Engineering the Inflammation Response to Infectious Traumatic Challenges," J. Royal Soc. Interface, no.48, pp. 989-1013, 10.1098/rsif.2009.0517.

Hogg, J.S., Clermont, G., and Parker, R.S., 2010, "Acute Inflammation Treatment via Particle Filter State Estimation and MPC," DYCOPS 2010, Leuven, Belgium.

Roy, A., and Parker, R.S., 2010, "A Phenomenological Model of Plasma FFA, Glucose, and Insulin Concentrations During Rest and Excercise," American Control Conference, Baltimore, MD.

Parker, R.S., 2009, "Automation and Control in Biomedical Systems; Section H, Chapter 76," in Handbook of Automation, S.Y. Nof, ed., Springer, pp. 1361-1378.

Harrold, J.M., and Parker, R.S., 2009, "Clinically Relevant Cancer Chemotherapy dose Scheduling via Mixed-Integer Optimization," Computers & Chemical Engineering, FOCAPO 2008 Special Issue, no.12, pp. 2042-2054, 10.1016/j.compchemeng.2009.06.005.

Jr., M.A., and Parker, R.S., 2009, "Pk/PD Modeling of Intracellular Gemcitabine Triphosphate Accumulation: Translating in vitro to in vivo," Foundations of Systems Biology in Engineering 2009, Denver, CO.

Beumer, J.H., Eiseman, J.L., Parise, R.A., Jr., J.A., Joseph, E., D'Argenio, D.Z., Parker, R.S., Kay, B., Covey, J.M., and Egorin, M.J., 2008, "Plasma Pharmacokinetics and Oral Bioavailability of 3,4,5,6-Tetrahydrouridine (THU), a Cytidine Deaminase Inhibitor, in Mice," Cancer Chemotherapy and Pharmacology, no.3, pp. 457-464.

Daun, S., Rubin, J., Vodovotz, Y., Roy, A., Parker, R.S., and Clermont, G., 2008, "An Ensemble of Models of the Acute Inflammatory Response to Bacterial Lipopolysaccharide in Rats: Results from Parameter Space Reduction," J. Theoretical Bio., no.4, pp. 843-853.

Jr., J.A., Eiseman, J.L., and Parker, R.S., 2008, "Nonlinear Model Predicitive Control for Dosing Daily Anticancer Agents: A Tamoxifen Treatment of Breast Cancer Case Study," Comput. Biol. Med., pp. 339-347.

Kanick, S.C., and Parker, R.S., 2008, "in silico Analysis of Photodynamic Therapy Dosimerty Using the Optical Pharmacokinetic System," SPIE - Photonics West, San Jose, CA.

Kanick, S.C., Eiseman, J.L., and Parker, R.S., 2008, "Pharmacokinetic Modeling of MGd Disposition in Mouse Tissues using Optical Pharmacokinetic System Measurements," Photodiagnosis and Photodynamic Therapy, no.4, pp. 276-284.

Doyle III, F.J., Seborg, D., Parker, R.S., Bequette, B.W., Jeffrey, A., Xia, X., Craig, I., and McAvoy, T.J., 2007, "A Tutorial on Biomedical Process Control," J. Process Control, no.7, pp. 571-594.

Florian Jr., J.A., and Parker, R.S., 2007, "Modeling Gemcitabine Triphosphate Production in Peripheral Blood Mononuclear Cells Following Intravenous Gemcitabine Administration," Foundations of Systems Biology in Engineering 2007, Stuttgart, Germany.

Jr., J.A., and Parker, R.S., 2007, "Feedback Control in Drug Delivery; Chapter 2," in Nanotechnology in Therapeutics: Current Technology and Applications, J.Z. Hilt, N.A. Peppas, and J.B. Thomas, eds., Horizon Bioscience, Norwish, UK.

Kanick, S.C., and Parker, R.S., 2007, "Monte-Carlo of Elastic Scattering Spectroscopic Measurement using the Optical Pharmacokinetic System (OPS)," SPIE - Photonics West, San Jose, CA.

Kanick, S.C., Eiseman, J.L., Joseph, E., Guo, J., and Parker, R.S., 2007, "Non-invasive Optical Sectroscopic Measurement of Motexafin Gadolinium in Murine Tissues: Comparison to High-Performance Liquid Chromatography," J. Photochemistry and Photobiology B: Biology, pp. 90-104.

McCarthy, J.J., Parker, R.S., and Besterfield-Sacre, M., 2007, "Chemical Engineering Curricular Redesign at the University of Pittsburgh," ASEE Annual Conference, Honolulu, HI.

Roy, A., and Parker, R.S., 2007, "Dynamic Modeling of Exercise Effects on Plasma Glucose and Insulin Levels," J. Diabetes Science and Technology, no.3, pp. 338-347.

Soni, A.S., and Parker, R.S., 2007, "Tailored Input Sequence Design for Third-Order Volterra Model Identification," Ind. & Eng. Chem. Res., no.3, pp. 818-829.

Parker, R.S., Doyle III, F.J., and Henson, M.A., 2006, "Integrating Biological Systems Content in the Process Dynamics and Control Curriculum," Chemical Engineering Education, no.3, pp. 181-188.

Antoine, A.L., and Parker, R.S., 2006, "An Analytical Solution to Multivariable Nonlinear MPC for Second-Order Laguerre Systems," ADCHEM '06, Gramado, Brazil.

Beumer, J.H., Joseph, E., Egorin, M.J., Parker, R.S., D;Argenio, D.Z., Covey, J.M., and Eiseman, J.L., 2006, "A Mass Balance and Disposition Study of the DNA-methyltransferase Inhibitor Zebularine (NSC 309132) and Three of its Metabolites in Mice," Clinical Cancer Res., no.19, pp. 5826-5833.

Harrold, J.M., and Parker, R.S., 2006, "Clinically-Relevant Cancer Chemotherapy Treatment Scheduling using Parameterized Mixed-Integer Programming," Chemical Process Control 7, Lake Louise, Alberta, Canada.

Roy, A., and Parker, R.S., 2006, "Dynamic Modeling of Exercise Effects on Plasma Glucose and Insulin Levels," ADCHEM 2006, Gramado, Brazil.

Roy, A., and Parker, R.S., 2006, "Dynamic Modeling of Free Fatty Acids, glucose, and Insulin: An Extended Minimal Model," Diabetes Technology and Therapeutics, no.6, pp. 617-626.

Roy, A., and Parker, R.S., 2006, "Mixed Meal Modeling and Disturbance Rejection in Type I Diabetic Patients," 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, New York, NY.

Barone, P.W., Parker, R.S., and Strano, M.S., 2005, "In-Vivo fluorescence Detection of glucose using a Single Walled Carbon Nanotube Optical Sensor: Design, Flurorophore Properties, Advantages, and Disadvantages," Analytical Chemistry, no.23, pp. 7556-7562.

Florian Jr., J.A., and Parker, R.S., 2005, "A Population Balance Model of Cell Cycle-Specific Tumor Growth," 16th IFAC World Congress on Automatic Control, Prague, Czech Republic.

Florian Jr., J.A., and Parker, R.S., 2005, "Empirical Modeling for Glucose Control in Diabetes and Critical Care," European Journal of Control, Special Section on Automatic Drug Delivery for Anesthesia and Critical Care, no.6, pp. 601-616.

Florian Jr., J.A., Eiseman, J.L., and Parker, R.S., 2005, "Modeling Quiescent Cells in Tumor Growth and Cancer Treatment," Foundations of Systems Biology in Engineering, Santa Barbara, CA.

Florian, J.A., Eiseman, J.L., and Parker, R.S., 2005, "Accounting for Quiescent Cells in Tumor Growth and Cancer Treatment," FOSBE Conference Special Issue of IEE Systems Biology, pp. 185-192.

Harrold, J.M., Zamboni, W.C., and Eiseman, J.L., 2005, "A Pharmacokinetic / Pharmacodynamic Model of 9-Nitrocamptothecin in SCID Mice," J. Pharmacokinetics and Pharmacodynamics, no.1, pp. 65-83.

Soni, A.S., and Parker, R.S., 2005, "Efficient Input Signal Design for Third-Order Volterra Model Identification," 16th IFAC World Congress on Automatic Control, Prague, Czech Republic.

Parker, R.S., 2004, "Insulin Delivery," in Encyclopedia of Biomaterials and Biomedical Engineering, G. Bowlin, and G. Wnek, eds., Marcell Dekker, Inc., pp. 857-866, New York.

Parker, R.S., Doyle III, F.J., and Henson, M.A., 2004, "Integration of Biological Systems Content into the Process Dynamics and Cotnrol Curriculum," DYCOPS 7, Cambridge, MA.

Parker, R.S., Harrold, J.M., Eiseman, J.L., Zamboni, W.C., Joseph, E., Strychor, S., and Egorin, M.J., 2004, "Toward Model-Based Chemotherapy Treatment Design," in Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis, Volume III, D.Z. D'Argenio, ed., Kluwer Academic Publishers, pp. 255-274, Norwell, MA.

Florian Jr., J.A., Eiseman, J.L., and Parker, R.S., 2004, "A Nonlinear Model Predictive Control Algorithm for Breast Cancer Treatment," DYCOPS 7, Cambridge, MA.

Harrold, J.M., and Parker, R.S., 2004, "Comparative Analysis of Chemotherapy Dose Scheduling Design Methodologies," American Control Conference, Boston, MA.

McCarthy, J.J., and Parker, R.S., 2004, "The Pillars of Chemical Engineering: A Block Scheduled Curriculum," Chemical Engineering Education, no.4, pp. 292-301.

Soni, A.S., and Parker, R.S., 2004, "Closed-Loop Control of Fed-Batch Bioreactors: A Shrinking-Horizon Approach," Ind. & Eng. Chem. Res., pp. 3381-3393.

Soni, A.S., and Parker, R.S., 2004, "Control-Relevant Identification for Third-Order Volterra Systems: A Polymerization Case Study," American Control Conference, Boston, MA.

Asoor, A.B., Muske, K.R., Kelly, W.J., and Parker, R.S., 2003, "Dynamic Cellular Modeling for Continuous Fermentation," American Control Conference, Denver, CO.

Komives, C., and Parker, R.S., 2003, "Bioreactor State Estimation and Control," Current Opinions in Biotechnology, pp. 468-474.

Rubb, J.D., and Parker, R.S., 2003, "Glucose Control in Type I Diabetic Patients: A Volterra Model-Based Approach," ADCHEM '03, Hong Kong, China.

Soni, A.S., and Parker, R.S., 2003, "Fed-Batch Bioreactor Control using Multi-Scale Models," American Control Conference, Denver, CO.

Parker, R.S., 2002, "Nonlinear Model Predicitive Control of a Continuous Bioreactor Using Approximate Data-Driven Models," American Control Conference, Anchorage, AL.

Florian Jr., J.A., and Parker, R.S., 2002, "A Nonlinear Data-Driven Approach to Type I Diabetic Patient Modeling," 15th IFAC World Congress on Automatic Control, Barcelona, Spain.

Lenart, P.J., and Parker, R.S., 2002, "Modeling Exercise Effects in Type I Diabetic Patients," 15th IFAC World Congress on Automatic Control, Barcelona, Spain.

Parker, R.S., 2001, "Efficient Nonlinear Model Predicitive Control: Exploiting the Volterra-Laguerre Model Sturcture," CPC 6, pp. 418-422, Tucson, AZ.

Parker, R.S., and Doyle III, F.J., 2001, "Control-relevant Modeling in Drug Delivery," Advances in Drug Delivery Reviews, pp. 211-248.

Parker, R.S., and Doyle III, F.J., 2001, "Optimal Control of a Continuous Bioreactor Using an Empirical Nonlinear Model," Ind. & Eng. Chem. Res., no.8, pp. 1939-1951.

Parker, R.S., Doyle III, F.J., and Peppas, N.A., 2001, "Blood Glucose Control in Diabetic Patients using the Intravenous Route," IEEE Eng. Med. Biol., no.1, pp. 65-73.

Parker, R.S., Gatzke, E.P., Mahadevan, R., Meadows, E.S., and Doyle III, F.J., 2001, "Nonlinear Model Predictive Control: Issues and Applications," in Advances in Non-Linear Model Predicitive Control, M. Cannon, and B. Kouvaritakis, eds., IEE Publishing, p. 272, London, UK.

Parker, R.S., Heemstra, D.H., Doyle III, F.J., Pearson, R.K., and Ogunnaike, B.A., 2001, "The Identification of Nonlinear Models for Process Control Using Tailored "Plant-Friendly" Input Sequences," J. Proc. Control Sp. Iss. SI, no.2, pp. 237-250.

Lenart, P.J., and Parker, R.S., 2001, "Glucose Control During Exercise in Type I Diabetic Patients," Topical Conference on Bioinformatics and Genomics at the AIChE Annual Meeting, Reno, NV.

Parker, R.S., Gatzke, E.P., and Doyle III, F.J., 2000, "Advanced Model Predictive Control (MPC) for Diabetic Patient Blood Glucose Control," American Control Conference, Chicago, IL.

Parker, R.S., Ward, J.H., Doyle III, F.J., and Peppas, N.A., 2000, "Robust H1 Glucose Control in Diabetes Using a Physiological Model.," AIChE Journal, no.12, pp. 2537-2549.

Doyle III, F.J., Gatzke, E.P., and Parker, R.S., 2000, "Process Control Modules: A Software Laboratory for Control Design," Prentice Hall PTR, New Jersey.

Rengasamy, R., Parker, R.S., and Doyle III, F.J., 2000, "Issues in Design of Input Signals for the Identification of Nonlinear Models of Process Systems," ADCHEM '00, Pisa, Italy.

Parker, R.S., Doyle III, F.J., and Peppas, N.A., 1999, "A Model-based Algorithm for Blood Glucose Control in Type I Diabetic Patients," IEEE - Transactions on Biomedical Engineering, no.2, pp. 148-158.

Doyle III, F.J., Parker, R.S., Pearson, R.K., and Ogunnaike, B.A., 1999, "Plant-friendly Identification of Second Order Volterra Models," Fifth European Control Conference, Karlsruhe, Germany.

Parker, R.S., and Doyle III, F.J., 1998, "Nonlinear Model Predictive Control of a Continuous Bioreactor at Near-Optimum Conditions," American Control Conference, pp. 2549-2554, Philadelphia, PA.

Doyle III, F.J., Gatzke, E.P., and Parker, R.S., 1998, "Practical Case Studies for Undergraduate Process Dynamics and Control Using the Process Control Modules (PCM)," Computer Applications in Engineering Education, no.3, pp. 181-191.

Parker, R.S., Doyle III, F.J., Rabinovitch, K.L., and Peppas, N.A., 1997, "time and Frequency Domain Analysis of Blood Glucose Regulation Algorithms," IEEE- Engineering in Medicine and Biology Society 19th Annual International Conference, Chicago, IL.

Parker, R.S., Rabinovitch, K.L., Doyle III, F.J., and Peppas, N.A., 1997, "Control Analysis of Pancreas Models for Optimal Insulin Delivery," Topical Conference on Biomaterials, Carriers for Drug Delivery, and Scaffolds for Tissue Engineering at the AIChE Annual Meeting, Los Angeles, CA.

Parker, R.S., Doyle III, F.J., Harting, J.E., and Peppas, N.A., 1996, "Model Predicitive Control for Infusion Pump Insulin Delivery," IEEE- Engineering in Medicine and Biology Society 18th Annual International Conference, Amsterdam, The Netherlands.

Doyle III, F.J., Peppas, N.A., Parker, R.S., Harting, J.E., and Podual, K., 1996, "Robust Model-based Control of Insulin Pumps and Devices," Intern. Symp. Control. Rel. Bioact. Mater., 23, pp. 174-175.

Gawel, S.P., Clermont, G., and Parker, R.S., 2012, "Model-Based Regulation of Glucose in Critical care," International Symposium on Intensive Care and Emergency Medicine, Brussels, Belgium.

Parker, R.S., 2011, "Systems (Engineering) Medicin: Model-Based Decision Making in Cancer and Inflammation," Department of Biomedical Engineering, Purdue University.

Gawel, S.P., Clermont, G., and Parker, R.S., 2011, "Model-Based Regulation of Glucose in Critical Care," AIChE Annual Meeting National Student Paper Comeptition, Minneapolis, MN.

McCarthy, J.J., and Parker, R.S., 2011, "Evaluation and Results for an Integrated Curriculum in Chemical Engineering," ASEE Annual Meeting, Vancouver, BC, Canada.

Song, S.O., Hogg, J.S., Parker, R.S., and Clermont, G., 2011, "A Compartmentalized Sepsis Model Based on Neutrophil Kinetics as a Decision Supporting Tool of Therapeutic Intervention," AIChE Annual Meeting, Minneapolis, MN.

Parker, R.S., 2010, "Systems (Engineering) Medicine: Advancing Treatment for Cancer and Inflammation," Department of Bioengineering, University of Pittsburgh.

Parker, R.S., 2010, "Systems (Engineering) Medicine: Model-Based Decision MAking in Cancer and Inflammation," Department of Chemical Engineering, Rutgers University.

Bouobda Tsemo, T., Hogg, J.S., Clermont, G., Shesko, M.D., and Parker, R.S., 2010, "Physiologically-Based Multi-Scale Model of Pahtogen-Induced IL1/IL1ra Dynamics," 9th International Conference on Complexity in Acute Illness, Atlanta, GA.

Song, S.O., Hogg, J.S., Clermont, G., and Parker, R.S., 2010, "Understanding Dysregulated Neutrophil Trafficking in Severe Sepsis," AIChE Annual Meeting, Salt Lake City, UT.

Parker, R.S., 2009, "A Model-Based Approach to Engineering Medical interventions," Department of Chemical engineering, University of Florida.

Parker, R.S., 2009, "Systems (Engineering) Medicine: Advancing Treatment for Cancer and Inflammation," Department of Chemical and Biomolecular Engineering, Cornell University.

Parker, R.S., Shesko, M.D., Hogg, J.S., and Clermont, G., 2009, "Multi-Scale Dynamics and Feedback inthe Pathogen-Induced Host Inflammatory Response," AIChE Annual Meeting, Memphis, TN.

Parker, R.S., 2008, "Engineering Medical Treatment Decisions: A Cancer Case Study," Foundations of computer Aided Process Operations (FOCAPO) 2008, Cambridge, MA.

Parker, R.S., 2008, "Modeling for Diabetes Control - Beyond Insulin and Glucose," Bio-Math Summer School and Workshop 2008, Middelfart, Denmark.

Parker, R.S., and Shannon, S.L., 2008, "Pillars of ChE: Systems Engineering I (ChE 0500/0501), an Integrated Course and Laboratory Experience," ASEE Annual Meeting, Pittsburgh, PA.

Hogg, J., Clermont, G., Kellum, J., and Parker, R.S., 2008, "Optimizing Hemoadsorption Therapy with Model Predicitive Control," 7th International Conference on Complexity in Acute Illness, Cologne, Germany.

Kanick, S.C., and Parker, R.S., 2008, "in silico Analysis of Photodynamic therapy Dosimerty Using the Optical Pharmacokinetic System," SPIE - Photonics West, San Jose, CA.

McCarthy, J.J., Parker, R.S., and Besterfield-Sacre, M., 2008, "Results and Initial Dissemination of the Pillars Curriculum at Pittsburgh," ASEE Annual Meeting, Pittsburgh, PA.

Piao, C., Inagaki, K., Kotchey, N., Ma, C., Charan, R., Parker, R.S., and Nakai, H., 2008, "Pharmacokinetic Studies of Various Serotype and Variant rAAV Vectors in Mice Reveal Distinct Features of rAAV Serotype 9," American Society of Gene Therapy 11th Annual Meeting, Boston, MA.

Parker, R.S., 2007, "Model-based Cancer Chemotherapy Design: from Developmental Therapeutics from First-Line Care," Department of Chemical Enginering, University of Texas at Austin.

Parker, R.S., 2007, "Model-based Cancer Chemotherapy Design: from Developmental Therapeutics to First-Line Care," Department of Chemical Engineering, Texas A&M University.

Parker, R.S., 2007, "Model-based Cancer Chemotherapy Design: from Developmental Therapeutics to First-Line Care," Department of chemical Engineering, University of Arkansas.

Parker, R.S., 2007, "Model-based Cancer Chemotherapy Design: from Developmetnal Therapeutics to First-Line Care," Department of Chemical and Petroleum Engineering, University of Kansas.

Jr., J.A., Egorin, M.J., Zamboni, W.C., Eiseman, J.L., Lagattuta, T.G., Belani, C.P., Chatta, G.S., Scher, H.I., Solit, D.B., and Parker, R.S., 2007, "A Physiologically-Based Pharmacokinetic (PBPK) and Pharmacodynamic Model of Docetaxel (Doc) and Neutropenia in Humans," American Society of Clinical Oncology Annual Meeting, Chicago, IL.

Kanick, S.C., and Parker, R.S., 2007, "Monte-Carlo of Elastic Scattering Spectroscopic Measurement using the Optical Pharmacokinetic System (OPS): Analysis of Sensitivity to Heterogeneous Chromophore Distribution," SPIE - Photonics West Meeting, San Jose, CA.

Roy, A., Clermont, G., Daun, S., and Parker, R.S., 2007, "A Mathematical Model of Acute Inflammatory Response to Endotoxin Challenge," AIChE Annual Meeting, Salt Lake City, UT.

Parker, R.S., 2006, "Advancing Cancer Treatment Design via Systems Analysis and Optimization," Centre for Process Systems Engineering, Department of Chemical Engineering, Imperial College London.

Parker, R.S., 2006, "Glucose Control in Diabetes and Critical Care," Fifth International Conference for Complexity in Acute Illness, Washington, D.C..

Parker, R.S., 2006, "The Pillars of Chemical Engineering: An Integrated Block-Scheduled Curriculum," NSF EEC Workshop, Washington, DC.

Antoine, A.L., and Parker, R.S., 2006, "Analytical Nonlinear Model Predicitive Control Using Third - Order Volterra-Laguerre Models," National Organization of Black Chemists and Chemical Engineers Annual Meeting, Los Angeles, CA.

Antoine, A.L., and Parker, R.S., 2006, "Analytical Nonlinear Model Predicitive Control Using Third - Order Volterra-Laguerre Models," National Society of Black Engineers Annual Meeting, Pittsburgh, PA.

Doyle III, F.J., Jovanovic, L., Palerm, C.C., Henson, M.A., Parker, R.S., and Bequette, B.W., 2006, "A Proposal for Diabetes Teaching Modules for the Undergraduat Chemical Engineering Curriculum," AIChE Annual Meeting, San Francisco, CA.

Florian Jr., J.A., Zamboni, W.C., Eiseman, J.L., Drasteva, M.D., Strychor, S., Joseph, E., Parise, R.A., Egorin, M.J., and Parker, R.S., 2006, "A Physiologically-Based Pharmacokinetic (PBPK) Model of Docetaxel in SCID Mice Bearing SKOV3 Human Ovarian Cancer Xenografts," American Association for Cancer Research Annual Meeting, Washington, DC.

Jr., J.A., and Parker, R.S., 2006, "Influence of Toxicity Effects on Model-Based Docetaxel Treatment Design," AIChE Annual Meeting, San Francsico, CA.

Kanick, S.C., Guo, J., Joseph, E., Egorin, M.J., Parker, R.S., and Eiseman, J.L., 2006, "Plasma Pharmacokinetics and Tissue Distribution of the Photodynamic therapy (PDT) Agent, Pc4, in Mice: Measurement Comparison of Optical Pharmacokinetic System (OPS) with High Performance Liquid Chromatography (HPLC)," American Association for Cancer Research Annual Meeting, Washington, DC.

McCarthy, J.J., Parker, R.S., and Besterfield-Sacre, M., 2006, "Pillars of Chemical Engineerin: A Block-Scheduled Curriculum," ASEE Annual Conference, Chicago, IL.

McCarthy, J.J., Parker, R.S., and Besterfield-Sacre, M., 2006, "Pillars of Chemical Engineering: a Block-Scheduled Curriculum," AIChE Annual Meeting, San Francisco, CA.

Roy, A., and Parker, R.S., 2006, "Dynamic Modeling and Model-Based Control of Exercise Response in Type 1 Diabetic Patients," AIChE Annual Meeting, San Francisco, CA.

Parker, R.S., 2005, "Engineering Cancer Treatment - A Process Systems Approach," Department of Chemical Engineering, University of South Carolina.

Parker, R.S., and Egorin, M.J., 2005, "Efficient Gemcitabine Delivery," Cancer and Leukemia Group B, Pharmacology and Experimental Therapeutics Core Meeting.

Parker, R.S., Fisher, J.W., Jr., J.A., Venook, A., Ratain, M.J., and Egorin, M.J., 2005, "Development of a Pharmacokinetically-Guided Gemcitabine (dFdC) Dosing Schedule to Reduce Potentially Excessive Plasma dFdC Concentrations," American Society of Clinical Oncology Annual Meeting, Orlando, FL.

Parker, R.S., Fisher, J.W., Jr., J.A., Venook, A.P., Ratain, M.J., and Egorin, M.J., 2005, "Development of a Pharmacokinetically-Guided Gemcitabine (dFdC) Dosing Schedule to Reduce Potentially Excessive Plasma dFdC Concentrations.," Sixth aNnual Symposium on Experimental Therapeutics in Oncology, Detroit, MI.

Balius, T., Eiseman, J.L., Soni, A.S., and Parker, R.S., 2005, "A Matlab(TM) Tool for Analyzing Multi-Drug (2-Drug) Chemotherapy," 8th Annual Undergraduate Research Symposium in the Chemical and Biological Sciences hosted by UPMC, Baltimore, MD.

Joseph, E., Parker, R.S., Guo, J., Kanick, S.C., Egorin, M.J., and Eiseman, J.L., 2005, "Non-Invasive Optical Pharmacokinetic Systems (OPS) Measurement of Motexafin Gadolium (GdTex) Concentrations in Tumors of SCID Mice Bearing MDA-MB-231 Breast Cancer Xenografts," American Association for Cancer Research Annual Meeting, Anaheim, CA.

Jr., J.A., and Parker, R.S., 2005, "A Population Balance Model of Senescent Tumor Modeling and Cancer," AIChE Annual Meeting, Cincinnati, OH.

Kanick, S.C., Eiseman, J.L., Joseph, E., Guo, J., and Parker, R.S., 2005, "Pharmacokinetic Analysis of Motexafin Gadolinium in Mouse Tissues using a Non-Invasive Optical Measurement System," AIChE Annual Meeting, Cincinnati, OH.

McCarthy, J., Abatan, A.A., Parker, R.S., and Besterfield-Sacre, M., 2005, "The Pillars of Chemical Engineering: A Work in Progress," Frontiers in Education Conference, Indianapolis, IN.

McCarthy, J.J., Abatan, A.A., Parker, R.S., and Besterfield-Sacre, M., 2005, "The Pillars of Chemical Engineering: A Work in Progress," AIChE Annual Meeting, Cincinnati, OH.

Roy, A., and Parker, R.S., 2005, "An "Extended Minimal Model" of Glucose, Insulin, and Fatty Acid Dynamics," Diabetes Technology and Therapeutics Annual Meeting, San Francisco, CA.

Roy, A., and Parker, R.S., 2005, "Dynamic Modeling of Fatty Acid, Glucose, Insulin Interactions," AIChE Annual Meeting, Cincinnati, OH.

Soni, A.S., and Parker, R.S., 2005, "Optimal Projection of Nonlinear Volterra Models onto the Laguerre Basis," AIChE Annual Meeting, Cincinnati, OH.

Parker, R.S., 2004, "Engineering Cancer Treatment - A Process Systems Appraoch," Department of chemical and Biological Engineering, University of Wisconsin, Madison.

Parker, R.S., 2004, "Engineering Cancer Treatment - A Process Systems Approach," Department of Chemical and Biological Engineering, Tufts University.

Parker, R.S., 2004, "Engineering Cancer Treatmetn - A Process Systems Approach," School of Chemical and Biomolecular Engineering, Georgia Tech.

Eiseman, J.L., Parise, R.A., Joseph, E., Strychor, S., Parker, R.S., Egorin, M.J., and Zamboni, W.C., 2004, "Pharmacokinetics of 9-Nitrocamptothecin (9NC) and 9-Aminocamptothecin (9AC) in SCID Mice Bearing Human Colon Xenografts, HT29," American Association for Cancer Research 95th Annual Meeting, (45: 1246, Abstract 5401), Orlando, FL.

Fisher, J.W., Florian Jr., J.A., Parker, R.S., Venook, A.P., Ratain, M.J., and Egorin, M.J., 2004, "Evaluation of Potentially Excessive Ineffective Plasma Gemcitabine (dFdC) Concentrations Produced by 30-Minute dFdC Infusions," American Society of Clinical Oncology Annual Meeting, New Orleans, LA.

Harrold, J.M., Eiseman, J.L., Zamboni, W.C., and Parker, R.S., 2004, "Modeling of Toxicity Effects and Nonlinearities in Pharmacokinetics of 9-nitrocamptothecin in Mice," AIChE Annual Meeting, Austin, TX.

Jr., J.A., Eiseman, J.L., and Parker, R.S., 2004, "A Nonlinear Model Predictive Control Algorithm for Breast Cancer Treatment.," Keynote Presentation, DYCOPS 7, Cambridge, MA.

McCarthy, J.J., and Parker, R.S., 2004, "The Pillars of Chemical Engineering: A Block Scheduled Curriculum," NSF EEC Workshop, Washington, DC.

Parker, R.S., 2003, "Cancer Chemotherapy Treatment Design Using Pharmacokinetic / Pharmacodynamic Models," School of Pharmacy, University of Pittsburgh.

Parker, R.S., 2003, "Clinically Relevant Control," AIChE Annual Meeting, San Francisco, CA.

Parker, R.S., 2003, "Interfacing Process Systems with Medicine: Case Studies in Cancer and Diabetes," Department of Chemical Engineering, Cleveland State University, Cleveland, OH.

Parker, R.S., 2003, "Model-based Approaches to Chemotherapy Treatment Design," 10th Workshop on Advanced Methods of PK (pharmacokinetic)/PD (pharmacodynamic) Systems Analysis, Los Angeles, CA.

Parker, R.S., 2003, "Using Pharmacokinetic / Pharmacodynamic Models in Cancer Chemotherapy Treatment Design," Department of Biomedical Engineering, University of Rochester.

Comerci, J.T., Joseph, E., Rippole, L., Parker, R.S., and Eiseman, J.L., 2003, "Cervical Pharmacokinetics of Motexafin Lutetium Measured Non-Invasively by Elastic Scattering Spectrometry (ESS)," American Society of Clinical Oncology Annual Meeting, Chicago, IL.

Florian Jr., J.A., Eiseman, J.L., and Parker, R.S., 2003, "Approximating Cancer Tumor Growth Dynamics using Cell Cycle Models in Series," AIChE Annual Meeting, San Francisco, CA.

Harrold, J.M., Parker, R.S., Egorin, M.J., Eiseman, J.L., Joseph, E., Jung, L., Strychor, S., and Zamboni, W.C., 2003, "A Model-Based Approach to Chemotherapy Treatment Design," Fourth Annual Symposium on Experimental Therapeutics in Oncology, Cleveland, OH.

Harrold, J.M., Eiseman, J.L., Zamboni, W.C., and Parker, R.S., 2003, "A Clinically Relevant Mixed Integer Approach to Chemotherapy Treatment Design," AIChE Annual Meeting, San Francisco, CA.

Parker, R.S., 2002, "A Process Systems Approach to Biomedicine," Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA.

Parker, R.S., 2002, "A Process Systems Approach to Biomedicine," Department of Chemical Engineering, Drexel University, Philadelphia, PA.

Parker, R.S., 2002, "Control & Biomedical Systems - Theory and Diabetes Applications," BD Technologies, Research Triangle Park, NC.

Parker, R.S., 2002, "Empirical Model Identification & Model Predictive Control," BD Technologies, Research Triangle Park, NC.

Parker, R.S., 2002, "Modeling and Controlling the Human Glucose-Insulin System," BD Technologies, Research Triangle Park, NC.

Parker, R.S., and Gatzke, E.P., 2002, "Using the Process Control Modules for Undergraduate Chemical Engineering Control Education.," ASEE Summer School for ChE Faculty, Boulder, CO.

Harrold, J.M., Eiseman, J.L., Zamboni, W.C., and Parker, R.S., 2002, "A Pharmacokinetic/Pharmacodynamic Model of Cancer Chemotherapy in SCID Mice," AIChE Annual Meeting, Indianapolis, IN.

Hosfield III, H.J., and Parker, R.S., 2002, "Analytical Solutions to Nonlinear Model Based Predicitive Control Problems," AIChE Annual Meeting National Student Poster Competition, Indianapolis, IN.

Lenart, P.J., DiMascio, L.N., and Parker, R.S., 2002, "Modeling Glycogen-Exercise Interactions in Type I Diabetic Patients," AIChE Annual Meeting, Indianapolis, IN.

Savard, J.M., and Parker, R.S., 2002, "A Frequency-Domain Parameter Estimation Algorithm for Improved Blood Glucose in Type I Diabetic Patients," AIChE Annual Meeting National Student Poster Competition, Indianapolis, IN.

Parker, R.S., 2001, "A Model-Based Approach to Glucose Concentration Control in Insulin-Dependent Diabetic Patients," Department of Chemical Engineering, Auburn University.

Parker, R.S., 2001, "A Process Sytems Approach to Biomedicine," Department of Chemical Engineering, University of Massachusetts Amherst, Amherst, MA.

Parker, R.S., 2001, "Control-Relevant Empirical Modeling for Bioreactor Regulation," 221st ACS National Meeting, San Diego, CA.

Lenart, P.J., and Parker, R.S., 2001, "Glucose Control During Exercise in Type I Diabetic Patients," AIChE Annual Meeting, Reno, NV.

Parker, R.S., 2000, "Insulin Delivery to Diabetic Patients under Uncertainty: A Robust Discrete-Time Approach," World Congress on Medical Physics and Biomedical Engineering, and the 22nd Annual International Conference of the IEEE - Engineering in Medicine and Biology Society Meeting, Chicago, IL.

Lenart, P.J., and Parker, R.S., 2000, "Exercise Effects in Type I Diabetic Patient Blood Glucose Control," AIChE Annual Meeting, Los Angeles, CA.

Parker, R.S., 1999, "Model-based Bioreactor Control," Technology Exchange Forum, E.I. duPont de Nemours and Company.

Parker, R.S., 1999, "Model-based control for Bioprocesses," Department of Chemical and Environmental Engineering, University of Arizona, Tucson, AZ.

Parker, R.S., 1999, "Model-based Control for Bioprocesses," Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, PA.

Parker, R.S., 1999, "Model-based Control for Bioprocesses," Department of Chemical Engineering, Clemson University, Clemson, SC.

Parker, R.S., 1999, "Model-based Control for Bioprocesses," Department of Chemical Engineering, Pennsylvania State University, University Park, PA.

Parker, R.S., Stamps, A.T., Peppas, N.A., and Doyle III, F.J., 1999, "robust H-infinity Control of Type I Diabetic Patient Blook Glucose," AIChE Annual Meeting, Dallas, TX.

Blowers, P., Kokkoli, E., and Parker, R.S., 1999, "Panel Discussion - Academic Interviewing/Choosing a Post-Doc," AIChE Annual Meeting, Dallas, TX.

Doyle III, F.J., and Parker, R.S., 1999, "Model-based Approaches to the Control of Glucose for Diabetes," AAMI Annual Meeting, Boston, MA.

Parker, R.S., and Doyle III, F.J., 1998, "Nonlinear Internal Model Control (IMC) of a Continuous Bioreactor with Unknown Reaction Pathways," AIChE Annual Meeting, Miami, FL.

Parker, R.S., and Doyle III, F.J., 1998, "Optimal Bioreactor Operation using Input-Output Model Based Predicitive Control," Biological Chemical Sciences and Engienering, E.I. duPont de Nemours and Company.

Parker, R.S., Doyle III, F.J., and Peppas, N.A., 1998, "Uncertainty and Robustness in Diabetic Patient Blood Glucose Control," AIChE Annual Meeting, Miami, FL.

Gatzke, E.P., Doyle III, F.J., and Parker, R.S., 1998, "Interactive Multimedia for the Process Control Modules (PCM)," AIChE Annual Meeting, Miami, FL.

Parker, R.S., and Doyle III, F.J., 1997, "Model-based Control of a Complex Bioreactor," Kenan Award Symposium, Union Carbide, Charlottesville, WV.

Parker, R.S., Doyle III, F.J., and Peppas, N.A., 1997, "Variable-rate Implantable Insulin Infusion Pumps - Closed-loop Maintenance of Normaglycemia Under Patient Variablility for Type I Diabetes," XIth congress of the Interantional Society for Artificial Organs, Providence, RI.

Parker, R.S., Doyle III, F.J., and Ramkrishan, D., 1997, "Nonlinear Adaptive Horizon-based Predictive Control of a Bioreactor using a State-Space Laguerre Model," AIChE Annual Meeting, Los Angeles, CA.

Gatzke, E.P., Parker, R.S., and Doyle III, F.J., 1997, "Process Control Modules for MATLAB 5.1 with Improved Graphics and Fermenter Case Study," Software demonstration at the AIChE Annual Meeting, Los Angeles, CA.

Parker, R.S., Doyle III, F.J., and Peppas, N.A., 1996, "Chemical Engineering Process Control and the Application of those Principles to the Diabetic Patient," Leiden University, Leiden, The Netherlands.

Parker, R.S., Doyle III, F.J., and Peppas, N.A., 1996, "Insulin Delivery Using Model-based Control of Infusion Pumps," AIChE Annual Meeting, Chicago, IL.

Parker, R.S., Doyle III, F.J., and Peppas, N.A., 1996, "Robust Model-based Control for Insulin Delivery in Diabetes," Twente Institute of Technology, Enschede, The Netherlands.

Doyle III, F.J., Parker, R.S., and Venkatasubramanian, V., 1996, "Practical Case Studies for Undergraduate Process Control Using the Purdue Control Modules (PCM)," Software demonstration at the AIChE Annual Meeting, Chicago, IL.

Knab, T., Clermont, G., and Parker, R.S., "Modeling Key Sepsis Related Cyrokine Removal from Blook via Hemoadsorption Device," AIChE Annual Meeting National Student Poster Competition, Salt Lake City, UT.

Keith, S., Parker, R.S., Harvey, N.G., Pettis, R.J., Denuzzio, D., and Vonk, G., 2006, "System and Method for Initiating and Maintaining Continuous, Long-Term Control of a Concentraion of a Substance in a Patient Using a Feedback or Model-based Controller Couple to a Single-Needle or Multi-Needle Intradermal (ID) Delivery Device," U.S. Patent 7,060,059 B2.